Automation

Whether it is for reaction optimization, catalyst screening, or library production the use of automation is critical to maximize data or compound accumulation and to reduce chemist workload. Whatever your requirement, ThalesNano has a viable solution.

High throughput organic synthesis

In order to circumvent the rising costs of research and development, the pharmaceutical industry relies upon high throughput organic synthesis (HTOS) to prepare the vast numbers of chemical analogues required to drive drug discovery programs through library generation, hit-to-lead, and lead development programs. In order for such an approach to be successful, the chemical transformations employed must be clean, high-yielding, and amenable to automation using either parallel or serial reactions and preferably a liquid handling format. In addition, a reaction protocol that utilizes reagents that can be easily removed from the product at the end of the reaction is highly desirable.

Reaction or catalyst screening

With reaction or catalyst screening a large number of conditions must be screened reproducibly in the quickest time possible with the widest parameter range allowable. Difficulties occur when handling multiple catalysts or gaseous reagents simply and safely.

At ThalesNano, the H-Cube Pro™, Gas Module™, and Phoenix Flow Reactor™ automated systems offers a truly wide range of possible options and reactions conditions. These include:

  • A parameter space ranging from 10-450°C and 1-100 bar (1450 psi).
  • Utilize 12 different reagent gases on one system. Hydrogen can be provided from endogenous production of hydrogen from water negating the need for a gas cylinder.
  • Up to six different heterogeneous catalysts may be screened in one run using ThalesNano’s CatCart changer.
  • Both heterogeneous or homogeneous catalysts may be screened on the same system via a column or loop reactor respectively. Loop options include 316L stainless steel, Teflon, and Hastelloy.
  • A range of different catalyst bed and loop sizes to experiment with different catalyst amounts or to vary the scale of the reaction.

For more information on what is possible, please send an e-mail directly to askthechemist@thalesnano.com with details of your requirements.

Reference:

Optimisation of Conditions for O-Benzyl and N-Benzyloxycarbonyl Protecting Group Removal using an Automated Flow Hydrogenator K.R. Knudsen; J. Holden; S.V. Ley and M. Ladlow; Adv. Syn. Cat.; 2007; 349; 535-538.