Hydrogenation

Catalytic hydrogenation is one of the most important transformations in the chemical industry today. Heterogeneously catalyzed hydrogenations are used for the following transformations:

  • Double or triple bond reductions.
  • Carbonyl to alcohol.
  • Nitro to amine.
  • Nitrile to amine.
  • Oxime to amine.
  • Debenzylation reactions.
  • Heterocycle saturations.
  • Dehalogenation reactions.
  • Desulphurization reactions.
  • Asymmetric hydrogenations.

Until now, hydrogenations were routinely performed using batch technology. However, there are many disadvantages to performing it in this fashion:

  • The use of hydrogen cylinders is a hazard.
  • The catalysts themselves can be pyrophoric making addition or filtration of these catalysts hazardous.
  • The degassing of solvents and purging of the reactor with nitrogen makes the reactions overcomplicated.
  • The mixing of hydrogen with solvent and catalyst is poor leading to long reaction times.

The combination of all these disadvantages means chemists seek to avoid this useful transformation.

At ThalesNano, we developed the H-Cube Series to ensure hydrogenation is again utilized in the lab.


Utilizing our patented, award winning, endogenous hydrogen generation technology, ThalesNano's hydrogenation can be performed safely in a standard laboratory fumehood at temperatures and pressures up to 150°C and 100 bar (1450 psi) respectively. Our systems are capable of operating at scales from mg to 100s of grams.The method of flowing a stream of compound through a packed catalyst bed increases the interaction between the three phases, increasing reaction rates by orders of magnitude and making it more effective and economical. Reactions now progress in minutes, so results can be achieved much faster than current methods.

hydrogenation, deprotection
Deprotection Reaction with the H-Cube® Reactor

To request a demonstration of one of our H-Cube Series reactors, please click here.