Substitution reactions are well known and long time applied reactions for building in or replacing function groups on aromatic or aliphatic organic molecules. The leaving groups can be halogenid-, pseudohalogenid groups or just simple hydrogen atoms. Depending on the behavior of the leaving group, the reactions can be performed in a catalytic or non-catalytic environment. These reactions are good solutions to create new molecules and even whole structure libraries.
Substitution Reactions with ThalesNano's Reactors
In batch chemistry the production of a reaction always depends on the volume of the applied flask. In flow chemistry this rule doesn’t stand. The production in this case depends only on the longevity of the catalyst, or when the reaction goes in non-catalytic circumstances the productivity depends only on time. Thus the flow chemical solutions for these reactions can be industrially interesting.
Thalesnano’s H-Cube Pro™ reactor can maintain 150°C temperature and 100 bar pressure in liquid flow system. The catalyst cartridges (CatCarts®) used with it can be filled with more than 100 types of catalysts, while the online linked ThalesNano Gas Module (for external gas supply from cylinders up to 200 bar) can controll 13 different gases, allowing numerous variations of triphasic systems to be created, therefore the number of potential substitution reactions is very high.
ThalesNano’s Phoenix™ Flow Reactor can maintain as even higher temperature (up to 450°C). With this parameter space the application scale also rises. One of these applications is a flourine - amine group exchange reaction we fulfilled with a stainless steel loop at 250°C.