Flavour and Fragrance
Flavour & Fragrance chemists are constantly focusing on making existing processes more efficient in order to lower the price of the final product or to generate new candidates for olfactory screening. Our customers have successfully utilized our products towards achieving these aims. Below you can find some ways our products can serve your goals.
Using the H-Cube®, chemists at Givaudan were able to screen catalysts rapidly and safely for the selective reduction of a number of compounds including the hydrogenation of a precursor to Pashminol™ without opening the cyclopropyl group.
Further details of their results with the H-Cube® can be found in the application note: Chemeoselective Hydrogenation of Fragrence Precursor Using H-Cube® Continuous Flow Reactor
|Brunner, G; Elmer, S; Schröder,F; Transition-Metal-Catalyzed Cyclopropanation of Nonactivated Alkenes in Dibromomethane with Triisobuthylaluminium; Eur. J. Org. Chem ; 2011; 4623-4633. - EUR J ORG CHEM|
Advantages of H-Cube for these chemistries
Low residence time enables higher selectivity coupled with fast screening. Results can be found in minutes!
Safety: Water electrolysis generation of hydrogen means no need to go to separate labs to conduct these experiments. They can be performed in your own fumehood.
The H-Cube Pro™ is capable of all of these, with improved temperature range, twice the hydrogen generation capability and easy to use, intellignet software.
High temperature reactions
The Phoenix Flow Reactor's capability of reaching 450°C coupled with residence times of seconds or minutes results in some very useful chemistry for the F&F industry. Using it, reactions can be carried out at high temperatures without destroying the molecules.
Reactions investigated are:
Mainly intramolecular reactions (no collisions)
- Pericyclic reactions
- Cycloadditions and retro-cycloadditions
- Sigmatropic reactions
- Extrusion of small molecules (e.g. CO, CO2, N2, etc.)
- Cleavage of the weakest single bond
- Ring expansions, ring closings
For more information on high temperature reactions, please also see our applications section.