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Selective alkene reduction - i.kovacs - 11-17-2014 11:02 AM

We have received this question to askthechemist@thalesnano.com:

I want to reduce an alkene but in the presence of a chlorophenyl. Is there a condition you could suggest using an H-cube.

If you would like to suppress the dehalogenation, then you can use a less active catalyst, with 1% metal content for instance. Pt less actively triggers dehalogenation than Pd and acidic supports may also help to prevent dehalogenation, like alumina and silica. So my suggestion would using a 1% Pt/Alumina, or a 1% Pt/Silica catalyst.
In terms of reaction conditions, I would recommend using a system pressure of less than or equal to 10 bar and between RT-100°C for this application in the H-Cube.