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Nitril reduction - Printable Version

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Nitril reduction - i.kovacs - 11-17-2014 12:12 PM

We have received this question to askthechemist@thalesnano.com:

I was hoping that you might be able to make a recommendation of a suitable catalyst for the following transformation:

[Image: image004.png]


I was hoping to run this with Raney Nickel. I do see in the literature, the potential to use a Ni EnCat catalyst. Suggestions?

Raney Nickel might be a good catalyst for the reaction, however there is a chance that the reaction would reduce the pyridine ring as well.
You may try 10% Pd/C as well, but it also might cause some dearomatization.
I would recommend to use either the Raney Ni or 10% Pd/C but try to manage the reaction on as low pressure as possible.
Regarding the encapsulated Nickel, it is unfortunately not available, however if you have that type of catalyst, we are happy to fill it in a CatCart for you.