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Selective benzonitrile reduction
11-17-2014, 10:57 AM (This post was last modified: 11-17-2014 10:57 AM by i.kovacs.)
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Selective benzonitrile reduction
We have received this question to askthechemist@thalesnano.com:

I would like to know if you have experience using the H-Cube Pro to selectively reduce a benzonitrile to a benzylamine in the presence of a pyridine. If so, could you provide me with possible conditions?

As a first idea I would recommend to use some low activity Pd/C (1% or 5%) on medium pressure (30-50 bar) and temperature (50-80°C).
If you observe an over reduction, than you should decrease the amount of the Hydrogen in the system (Info screen, before stating the reaction), to have the optimal amount present.
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Selective benzonitrile reduction - i.kovacs - 11-17-2014 10:57 AM

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