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Solubility question
11-17-2014, 12:06 PM (This post was last modified: 11-17-2014 12:06 PM by i.kovacs.)
Post: #1
Solubility question
We have received this question to

I need to run a H-cube reduction using Pd(OH)2, but my starting material have a low solubility in MeOH, EtOAc, AcOH and THF etc. It’s dissolved in DCM well. May I ask what’s solvent you would recommend for this reduction? It’s reduction of olefin.

The usual concentration we use in the H-Cube is around 0.05 M, but you can eventually go to lower concentrations as well. When most of the material is already dissolved, you can try to dissolve the remaining with the help of some sonication.

However, when low concentration doesn't help, you can try using water as solvent - depending on your chemical structure. If water is not an option, concentrated acetic acid may help. The H-Cube is made of stainless steel, it should withstand the acetic acid, but please note that elevated temperatures may reduce resistance. Make sure you wash it well after the reaction.
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