The H-Cube Tutor™ hydrogenation reactor - a simple and safe reactor to enable undergraduates and researchers to perform hydrogenation as part of their degree.
Current undergraduate programs do not include a practical session on hydrogenation due to the safety concerns with handling hydrogen (in Balloons or cylinders) and pyrophoric catalysts.
However, approximately 5-10% of reactions in the whole of the chemical industry are forms of hydrogenation and so it is essential for their future industrial or academic careers that the students gain first hand practical experience wih hydrogenation during university.
The H-Cube Tutor™ is a continuous-flow hydrogenation reactor designed solely for academic affiliations for education purposes.
The H-Cube Tutor™ is derived from the ThalesNano H-Cube®, and R&D 100 Award winning bench top hydrogenation reactor, which has been available to both academia and industry since 2005. The H-Cube® has been widely adopted by the pharmaceutical industry for medicinal chemistry research and is rapidly becoming the standard for hydrogenation, replacing the existing "shaker" type technologies.
The H-Cube Tutor™ retains the key benefits as the original H-Cube®, such as:
For the first time, undergraduates may be taught hydrogenation during a practical lesson safely and effectively. The combination of utilizing catalyst cartridges, hydrogen generated through water electrolysis, and fast results means that practical lessons can be easily planned around the The H-Cube Tutor™ with chemists of all levels.
Among others the following common reactions may all be demonstrated simply and safely to students in minutes:
Some examples performed on the H-Cube Tutor™ are presented here:
The H-Cube Tutor™ is not just an educational tool. The H-Cube Tutor™ has the same high reactivity as the original H-Cube®. Reactions still progress in minutes between scales of 10 mg and 100 g making the reactor ideal for research too.
Research Institutes such as University of Cambridge, Boston University, University of Kansas, University of Moffit, University of Graz, University of Milan, University of Queensland, University College Dublin, ETH Zurich Institute have all already benefited from using H-Cube® for research. Scientific papers featuring the H-Cube® are published regularly by these Universities and ThalesNano and are referenced below.
Win a 2-day tuition and training at Thalesnano Headquarters!
The first 5 universities to purchase an H-Cube Tutor™ will win an all expenses paid trip for one of their students to ThalesNano's Flow Chemistry Research Centre in Budapest, Hungary for a 2-day tuition and training!
References:
1. Ritter, S., Natural product synthesis on the fly. Multistep continuous reaction shows the power of automated flow synthesis, Chemical&Engineering News; 2006; 84(10); 17
2. Desai, B. and Kappe, O., Heterogeneous hydrogenation reactions using a continuous flow high pressure device, J.Combi. Chem.; 2005; 7; 5; 641-643
3. Saaby, S., Knudsen, K.R., Ladlow, M., Ley, S.V., The use of a continuous flow reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines; Chem. Commun.; 2005; 23; 2909-11
4. Spadoni, S., Jones, R., Urge, L. and Darvas, F.; The recent advancement of hydrogenation technology and their implications for drug discovery research; Chem. Today, January/February 2005; 36-39
5. Jones, R., Godorhazy, L., Szalay, D., Urge, L., Darvas, F., A novel method for high-throughput reduction of compounds through automated sequential injection into a continuous-flow microfluidic reactor, QSAR Comb. Sci., 2005, 24(6); 722-727
6. Spadoni, C, Jones, R., Urge, L., Darvas, F., Scaling up and validation of hydrogenation reactions using a continuos-flow microfluidics-based reactor, H-Cube®; Chem. Today; February/March 2006; 38-41
7. Jones, R., Godorhazy, L., Varga, N., Szalay, D., Urge, L., and Darvas, F., Continuous-flow high pressure hydrogenation reactor for optimization and high-throughput synthesis; J. Comb. Chem.; 2006; 8(1); 110-116
8. Szollosi, Gy., Herman, B., Fulop, F., and Bartok, M.; Continuous enantioselective hydrogenation of activated ketones on a Pt-Cd chiral catalyst: use of H-cube reactor system, Reaction Kinetics and Catalysis Letters, 2006, 88(2), 391-398
9. Franckevicius, V, Knudsen, K.R., Ladlow, M., Longbottom, D.A. and Ley, S.V.; Practical Synthesis of (S)-Pyrrolidin-2-yl-1H-tetrazole, Incorporating Efficient Protecting Group Removal by Flow-reactor Hydrogenolysis, Synlet., 2006, 889-892
10. Baxendale, I.R., Griffiths-Jones, C.M., Ley, S.V. and Tranmer, G.K., Preparation of the Neolignan Natural Product Grossamide by a Continuous Flow Process, Synlett, 2006, 427-430
11. Baxendale, I.R., Deeley, J., Griffiths-Jones, C.M., Ley, S.V., Saaby, S. and Tranmer, G.; A Flow Process for the Multi-Step Synthesis of the Alkaloid Natural Product Oxomaritidine: A New Paradigm for Molecular Assembly, J. Chem. Soc., Chem. Commun., 2006, 2566-2568.
12. Desai, B., Dallinger, D., Kappe, C.O., Microwave-Assisted Solution Phase Synthesis of Dihydropyrimidine C5 Amides and Esters, Tetrahedron, 2006, 62, 4651-4664
13. Koppotz, M., Eis, K., Automated Medicinal Chemistry, Drug Discovery Today, 2006, 11(11/12), 561-568
14. Microfluidics in commercial applications; an industry perspective, Lab Chip, 2006, 6, 1118-1121
H-Cube Tutor™ Application Note [1]
Links:
[1] http://thalesnano.com/files/file/brochures/applications/ThalesNano_H_Cube_Tutor_Appl_Note.pdf