Gas Module

The H-Cube® Gas Module works seamlessly with any existing H-Cube® or the new H-Cube Pro™ to allow a further 12 gases to be used at up to 100 bar using the same touch screen intuitive controls. Reactions such as carbonylation or oxidations can now be performed on the H-Cube® at the same high pressures widening the reactor’s chemistry ability significantly.

Gas Module Brochure
Application Notes

Scientific publications utilizing the Gas Module

Gas Module provides you:

  • 13 gases in one device
  • Fast reactions - chemistry in minutes
  • High pressure reactions to 100 bar
  • Intuitive User Interface



Compressed Air, O2, CO, ethylene, SynGas for hydroformylations, CH4, C2H6, He, H2, N2, N2O, NO, Ar.


Just like with hydrogenation on the H-Cube®, reactions with other gases complete in less than 10 minutes.


Up to 100 bar capability.


All high quality stainless steel parts.


3 button stand-alone control or via simple touch screen control on H-Cube Pro™

H-Cube Pro™ added benefits

• Savable and reproducible experiment methods
• Automated blockage or solvent leak detection
• Touch screen user interface

Extended chemistry space

We are happy to announce the first fully automated flow chemistry platform dedicated to automating high pressure and temperature reactions, with or without reagent gases such as carbon monoxide or hydrogen. The automated system features an H-Cube Pro, Phoenix Flow Reactor, and Gas Module combined with an autosampler. The PC controlled automated system is able to automatically inject starting materials into the reaction zone and then to collect product as well. The combined system is one of the most versatile automation systems available and can perform the following

• Reactions from 10-450 °C and 1-100 bar (1450 psi).
• Up to 13 different reagent gases.
• Heterogeneous or homogeneous catalysis.:

Gas Module FAQ

1. What instruments can be used with the Gas Module?
You can connect the Gas Module to the H-Cube Pro and H-Cube so far.

2. What is the difference when it is connected to H-Cube and H-Cube Pro?
The software of H-Cube Pro can monitor and control the Gas Module, as an External module. When the Gas Module is connected to the H-Cube the unit must be utilized as a stand alone system. There are several safety features implemented into both software.

3. Can the hydrogen generated by the H-Cube or H-Cube Pro be used when utilizing the Gas Module?
For safety reasons, the H-Cube must be used in No Gas mode so there will not be any hydrogen generated by the cell in the reaction line. When the Gas Module is connected to the H-Cube Pro, its software automatically blocks the introduction and generation of hydrogen.

4. Does the Gas Module generate the 13 gases itself?
No. The Gas Module actually does not generate any gases, it only regulates the amount of gas coming from the cylinder.

5. How many gases can be introduced into the system at one time?
Only one cylinder can be used at a time, so the amount of gases depends on the gas type in the cylinder. E.g. gas mixtures such as SynGas can be introduced,.

6. At what pressures can I use each gas?
Only gas can be introduced into the Gas Module, you have to make sure the gas pressure is under the vapor pressure. Reaction pressure has to be approximately 15 bar lower than the pressure of the tank.

Vapor pressure of each gas is given in the below table.

Gas Name Gas Type Vapor Pressure
Air Air NA
Argon Ar NA
Ethylene C2H4 NA
Ethane C2H6 543 psi (37 bar)
Methane CH4 Non condensable
Carbon Monoxide CO NA
Hydrogen H2 NA
Helium He NA
Nitrogen N2 NA
Nitrous Oxide N2O 736 psi (50 bar) at 20°C
Nitric Oxide NO 508 psi (35 bar) at 20°C
Oxygen O2 NA
Synthesis gas Syn NA

7. What is the maximum amount of gas that can be introduced?

Gas Name Gas Type Max flow rate(ml/min) Max flow rate(mmol/min) Max flow rate(mg/min)
Air Air 100 4.46 128.8
Argon Ar 140 6.23 248.4
Ethylene C2H4 62 2.77 77.4
Ethane C2H6 50 2.19 65.7
Methane CH4 76 3.39 54.2
Carbon monoxide CO 100 4.44 124.4
Hydrogen H2 101 4.5 9.1
Helium He 139 6.19 25
Nitrogen N2 100 4.46 125
Nitrous Oxide N2O 76 3.36 147
Nitric Oxide NO 100 4.46 133.9
Oxygen O2 99 4.41 141.3
Synthesis Gas Syn 100 4.46 62.2

10. How is the gas pressure generated?
The reaction pressure is set on the H-Cube or H-Cube Pro, between atmospheric pressure and 100 bar. The gas cylinder pressure must be above the inlet pressure of the H-Cube. No compressor is used. Please ensure the gas source is able to maintain a pressure above the H-Cube inlet pressure above the entire duration of the reaction.

11. Can I use cylinder with dip tube installed?
No. Only dry gases can be introduced into the Gas Module. The use of wet gases is also not allowed.

12. How does the Gas Module connect to the standard H-Cube?
The Gas Module is connected to the H-Cube through a check valve supplied by ThalesNano. This check valve
is connected to the front panel of the H-Cube, as shown on the picture below.

The H-Cube and Gas Module are each controlled separately by their own built in software.

13. Do I need any upgrade on the H-Cube system to be able to use the H-Cube or H-Cube Pro with the Gas Module?
None of the standard H-Cubes needs any upgrade, but will require a connection package. H-Cube Pros with a serial number below 41 will. H-Cube Pro upgrades will be given free of charge upon purchase of a gas module.

14. What else do I need to use the Gas Module with the H-Cube?
You will need a gas cylinder with a pressure regulator on attached. The external fitting should be able to connect to a 1/8 stainless steel tube.

15. What is the maximum pressure the cylinder can be set without damaging the Gas Module?
A maximum of 200 bar should be applied.

16. What regulators can be used which are compatible with the Gas Module?
All the gas regulators can be used which parameter’s fit to the specification of the Gas Module, If you order regulator from Linde AG, then please chose the following one: C 200/1 A, 10-200 bar outlet pressure, HiQ code: 3103