Select category:
An efficient enzymatic method for the preparation of a key Taxol side-chain intermediate

Galla, Zs.; Beke, F.;Forró, E.;Fülöp, F.; Enantioselective hydrolysis of 3,4-disubstituted β-lactams. An efficient enzymatic method for the preparation of a key Taxol side-chain intermediate; Journal of Molecular Catalysis B: Enzymatic; 2016; 123; 107–112

link to article

To top
Flow chemistry vs. flow analysis

Trojanowicz, M.; Flow chemistry vs. flow analysis; Talanta; 2016; 146; 621-640

link to article

To top

Hajba, L.; Guttman, A.;Continuous-flow biochemical reactors: Biocatalysis, bioconversion, and bioanalytical applications utilizing immobilized microfluidic enzyme reactors; Journal of flow chemistry; 2016; 6(1); 8-12

link to article

To top

Movsisyan, M.; Moens, M. M.; Stevens, C. V.; Chapter Two – Flow Synthesis of Heterocycles; Advances in Heterocyclic Chemistry; 2016; 119; 25-55

link to article

To top

Benito-Pena, E.; González-Vallejo, V.; Rico-Yuste, A.; Barbosa-Pereira, L.; Cruz, J. M.; Bilbao, A.; Alvarez-Lorenzo, C.; Moreno-Bondi, M. C.; Molecularly imprinted hydrogels as functional active packaging materials; Food Chemistry; 2016; 190; 487–494

link to article

To top

Dragulescu-Andrasi, A.; Miller, L. Z.; Chen, B.; McQuade, D. T.; Shatruk M.; Facile Conversion of Red Phosphorus into Soluble Polyphosphide Anions by Reaction with Potassium Ethoxide; Angewandte Chem.; 2016; 55(12); 3904-3908

link to article

To top
Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification

Ouchi, T.; Mutton, R. J.; Rojas, V.; Fitzpatrick, D. E.; Cork, D. G.; Battilocchio, C.; Ley, S. V.; Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification; ACS Sustainable Chem.&Eng.; 2016; 4(4); 1912-1916

link to article

To top

Fekete, M.; Kocsis L.; Dormán, Gy.; Darvas, F.; A continuous flow process for the green and sustainable production of N-alkyl imidazoles; Green Processing and Synthesis; 2016; 5(3); 239-246

link to article

To top
High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences

Bogdan, R. A.; Charaschanya, M.; Dombrowski, A. W.; Wang, Y.; Djuric, S. W.; High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences; Org. Lett.; 2016; 18(8), 1732-1735

link to article

To top
Nucleophilic aromatic substitution of heterocycles using a high-temperature and high-pressure flow reactor

Charaschanya, M.; Bogdan, A. R.; Wang, Y.; Djuric, S. W.; Nucleophilic aromatic substitution of heterocycles using
a high-temperature and high-pressure flow reactor; Tetrahedron Letters; 2016; 57(9); 1035-1039

link to article

To top
Liquid phase oxidation chemistry in continuous-flow microreactors

Gemoets, H. P. L.; Su, Y.; Shang, M.; Hessel V.; Luque, R.; Noël, T.; Liquid phase oxidation chemistry in continuous-flow microreactors; Chem. Soc. Rev.; 2016; 45; 83-117

link to article

To top
The Use of Gases in Flow Synthesis

Mallia, C. J.; Baxendale, I. R.; The Use of Gases in Flow Synthesis; Org. Process Res. Dev.; 2016; 20(2); 327–360

link to article

To top
Taming hazardous chemistry by continuous flow technology

Movsisyan, M.; Delbeke, E. I. P.; Berton, J. K. E. T.; Battilocchio, C.; Ley, S. V.; Stevens, C. V.; Taming hazardous chemistry by continuous flow technology; Chem. Soc. Rev.; 2016; ??; ??

link to article

To top

Sipocz, T.; Lengyel., L.; Sipos, G.; Kocsis, L.; Dorman, Gy.; Jones, R. V.; Darvas, F.; Regioselective catalytic alkylation of N-heterocycles in continuous flow; J. Flow Chem.; 2016; 6(2); 117–122

link to article

To top

Singh, R.; Lee, H. J.; Singh, A. S.; Kim, D. P.; Recent advances for serial processes of hazardous chemicals in fully integrated microfluidic systems; Korean Journal of Chemical Engineering; 2016; 33(8); 2253-2267

link to article

To top
Merging Single-Atom-Dispersed Silver and Carbon Nitride to a Joint Electronic System via Copolymerization

Chen, Z.; Pronkin, S.; Fellinger, T. P.; Kailasam, K.; Vilé, G.; Albani, D.; Krumeich, F.; Leary, R.; Barnard, J.; Thomas, J. M.; Pérez-Ramírez, J.; Antonietti, M.; Dontsova, D.; Merging Single-Atom-Dispersed Silver and Carbon Nitride to a Joint Electronic System via Copolymerization with Silver Tricyanomethanide; ACS Nano; 2016; 10(3); 3166−3175

link to article

To top
Nitro Lignin-Derived Nitrogen-Doped Carbon as an Efficient and Sustainable Electrocatalyst for Oxygen Reduction

Graglia, M.; Pampel, J.; Hantke, T.; Fellinger, T. P.; Esposito D.; Nitro Lignin-Derived Nitrogen-Doped Carbon as an Efficient and Sustainable Electrocatalyst for Oxygen Reduction; ACS Nano; 2016; 10(4); 4364-4371

link to article

To top
Toward the Synthesis of Noroxymorphone via Aerobic Palladium-Catalyzed Continuous Flow N‑Demethylation Strategies

Gutmann, B.; Elsner, P.; Cox, D. P.; Weigl, U.; Roberge, D. M.; Kappe, C. O.; Toward the Synthesis of Noroxymorphone via Aerobic Palladium-Catalyzed Continuous Flow N‑Demethylation Strategies; ACS Sustainable Chem. Eng.; 2016; Article ASAP

link to article

To top

Csordás, B.; Nagy, A.; Harmat, V.; Zsoldosné-Mády, V.; Leveles, I.; Pintér, I.; Farkas, V.; Perczel, A.; Origin of problems related to Staudinger reduction in carbopeptoid syntheses; Amino Acids; 2016; ?; 1-15

link to article

To top

Ghosh, C. K.; Chakraborty, A.; Chemistry of 3-carbonyl-2-methyl-4-oxo-4H-1-benzopyrans; ARKIVOC; 2016; 2016(1); 111-149

link to article

To top
Synthetic multivalent ligands for cholera & cholera-like toxins: Protected cyclic neoglycopeptides

Kumar, V.; Yadav, N.; Kartha, K. P. R.; Synthetic multivalent ligands for cholera & cholera-like toxins: Protected cyclic neoglycopeptides; Carbohydrate Research; 2016; 431; 47-55

link to article

To top
Ligand ordering determines the catalytic response of hybrid palladium nanoparticles in hydrogenation

Albani, D.; Vilé, G.; Mitchell, S.; Witte, P. T.; Barrios, N. A.; Verel, R.; López, N.; Pérez-Ramírez, J.; Ligand ordering determines the catalytic response of hybrid palladium nanoparticles in hydrogenation; Catal. Sci. Technol.; 2016; 6(6); 1621-1631

link to article

To top
Fine chemical syntheses under flow using SiliaCat catalysts

Ciriminna, R.; Pandarus, V.; Béland, F.; Pagliaro, M.; Fine chemical syntheses under flow using SiliaCat catalysts; Catal. Sci. Technol.; 2016; 6(13); 4678-4685

link to article

To top
 Insights into the activity, selectivity and stability of catalysts in the continuous flow hydroconversion of furfural

Garcia-Olmo, A. J.; Yepez, A.; Balu, A. M.; Romero, A. A.; Li, Y.; Lugue, R.; Insights into the activity, selectivity and stability of heterogeneous catalysts in the continuous flow hydroconversion of furfural; Catal. Sci. Technol.; 2016; 6(13); 4705-4711

link to article

To top

Lücke, D.; Dalton, T.; Ley, S. V.; Wilson Z. E.; Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry; Chem. Eur. J.; 2016; 22(12); 4206 – 4217

link to article

To top

Rossetti, I.; Comagnoni, M.; Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry; Chemical Engineering Journal; 2016; 296; 56-70

link to article

To top

Megyesi, R.; Forró, E.; Fülöp, F.; Enzymatic Strategy for the Resolution of New 1-Hydroxymethyl Tetrahydro-b-carboline Derivatives in Batch and Continuous-Flow Systems; ChemistryOpen; 2016; 5(3); 254 – 260

link to article

To top

Gallagher, C. M.; Garri, C.; Cain, E. L.; Ang, K. K. H.; Wilson, C. G.; Chen, S.; Hearn, B. R.; Jaishankar, P.; Aranda-Diaz, A.; Arkin, M. R.; Renslo, A. R.; Walter, P.; Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch; eLife; 2016; 5; e:11878

link to article

To top

Nuzzi, A.; Fiasella, A.; Ortega, J. A.; Pagliuca, C.; Ponzano, S.; Pizzirani, D.; Bertozzi, S. M.; Ottonello, G.; Tarozzo, G.; Reggiani, A.; Bandiera, T.; Bertozzi, F.; Piomelli, D.; Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies; Eur. J. Med. Chem.; 2016; 111; 138-159

link to article

To top
Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Z.; Pinson, J. A.; Mountford, S. J.; Orive, S.; Schoenwaelder, S. M.; Shackleford, D.; Powell, A.; Nelson, E. M.; Hamilton, J. R.; Jackson, S. P.; Jennings, I. G.; Thompson, P. E.; Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922); European Journal of Medicinal Chemistry; 2016; 122; 339-351

link to article

To top
Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis

Jarrad, A. M.; Debnath, A.; Miyamoto, Y.; Hansford, K. A.; Pelington, R.; Butler, M. S.; Bains, T.; Karoli, T.; Blaskovich, M. A. T.; Eckmann, L.; Cooper, M. A.; Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis; European Journal of Medicinal Chemistry; 2016; 120; 353-362

link to article

To top
Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow

Nagendiran, A.; Sörensen, H.; Johansson, M. J.; Tai, C. W.; Bäckvall, J. E.; Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow; Green Chem.; 2016; 18(9); 2632-2637

link to article

To top
Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent

Vianello, P.; Botrugno, O. A.; Cappa, A.; Zuffo, R. D.; Dessanti, P.; Mai, A.; Marrocco, B.; Mattevi, A.; Meroni, G.; Minucci, S.; Stazi, G.; Thaler, F.; Trifiró, P.; Valente, S.; Villa, M.; Mercurio, C.; Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent; J. Med. Chem.; 2016; 59(4); 1501–1517

link to article

To top
Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma

Onions, S. T.; Ito, K; Charron, C. E.; Brown, R. J.; Colucci, M.; Frickel, G. H.; Joly, K.; King-Underwood, J.; Kizawa, Y.; Knowles, I.; Murray, P. J.; Novak, A.; Rani, A.; Rapeport, G.; Smith, A.; Strong, P.; Taddei, D. M.; Williams, J. G.; Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma; Journal of Medicinal Chemistry; 2016; 59(5); 1727-1746

link to article

To top
SAR Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1,2 and BCR-ABL1 Inhibitors Targeting Leukemic Cells

Cherian, J.; Nacro, K.; Poh, Z. Y.; Guo, S.; Jeyaray, D. A.; Wong, Y. X.; Ho, M.; Yang, H. Y.; Joy, J. K.; Kwek, Z. P.; Liu, B.; Wee, J. L. K.; Ong, E. H.; Choong, M. L.; Poulsen, A.; Lee, M. A.; Pendharkar, V.; Ding, L. J.; Manoharan, V.; Chew, Y. S.; Sangthongpitag, K.; Lim, S.; Ong, S. T.; Hill, J.; Keller, T. H.; Structure–Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells; J. Med. Chem.; 2016; 59(7); 3063–3078

link to article

To top
Optically Pure, Structural, and Fluorescent Analogues of a Dimeric Y4 Receptor Agonist Derived by an Olefin Metathesis Approach

Liu, M.; Mountford, S. J.; Richardson, R. R.; Groenen, M.; Holliday, N. D.; Thompson, P. E.; Optically Pure, Structural, and Fluorescent Analogues of a Dimeric Y4 Receptor Agonist Derived by an Olefin Metathesis Approach; J. Med. Chem.; 2016; 59; 6059−6069

link to article

To top
Total Synthesis and Biological Evaluation of Tubulysin Analogues

Colombo, R.; Wang, Z.; Han, J.; Balachandran, R.; Daghestani, H. N.; Camarco, D. P.; Vogt, A.; Day, B. W.; Mendel, D.; Wipf, P.; Total Synthesis and Biological Evaluation of Tubulysin Analogues; J. Org. Chem.; 2016; Article ASAP

link to article

To top
Insights into the selective hydrogenation of levulinic acid to-valerolactone using supported mono- and bimetallic catalysts

Al-Naji, M.; Yepez, A.; Balu, A. M.; Romero, A. A.; Chen, Z.; Wilde, N.; Li, H.; Shih, K.; Gläser, R.; Luqueb, R.; Insights into the selective hydrogenation of levulinic acid to-valerolactone using supported mono- and bimetallic catalysts; Journal of Molecular Catalysis A: Chemical; 2016; 417; 145–152

link to article

To top
Development of biolubricants from vegetable oils via chemical modification

McNutt, J.; He, Q. S.; Development of biolubricants from vegetable oils via chemical modification; Journal of Industrial and Engineering Chemistry; 2016; 36; 1-12

link to article

To top
Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups

Workman, D. G.; Hunter, M.; Dover, L. G.; Tétard, D.; Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups and their evaluation as antimicrobial agents; Journal of Inorganic Biochemistry; 2016; 160; 49–58

link to article

To top

Ötvös, S. B.; Hsieh, C. T.; Wu, Y. C.; Li, J. H.; Chang, F. R.; Fülöp, F.; Continuous-Flow Synthesis of Deuterium-Labeled Antidiabetic Chalcones: Studies towards the Selective Deuteration of the Alkynone Core; Molecules; 2016; 21(3); 318-329

link to article

To top
 Library synthesis of cardiomyogenesis inducing compounds using an efficient two-step-one-flow process

Schön, M.; Dreier, D.; Schnürch, M.; Mihovilovic, M. D.; Library synthesis of cardiomyogenesis inducing compounds using an efficient two-step-one-flow process; Monatsh Chem; 2016; 147(3); 523-532

link to article

To top

Pilkington-Miksa, M.; Araldi, E. M.; Arosio, D.; Belvisi, L.; Civera, M.; Manzoni, L.; New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics; Org Biomol Chem.; 2016; 14(12); 3221-3233

link to article

To top

Salamoun, J. M.; McQueeney, K. E.; Patil, K.; Geib, S. J.; Sharlow, E. R.; Lazo, J. S.; Wipf, P.; Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor; Org. Biomol. Chem.; 2016; 14(27); 6398-6402

link to article

To top
Enabling the Scale-Up of a Key Asymmetric Hydrogenation Step in the Synthesis of an API

Amara, Z.; Poliakoff, M.; Duque, R.; Geier, D.; Francio, G.; Gordon, C. M.; Meadows, R. E.; Woodward, R.; Leitner, W.; Enabling the Scale-Up of a Key Asymmetric Hydrogenation Step in the Synthesis of an API Using Continuous Flow Solid-Supported Catalysis; Org. Process Res. Dev.; 2016; 20; 1321−1327

link to article

To top
Online monitoring and analysis for autonomous continuous flow self-optimizing reactor systems

Fabry, D. C.; Sugiono, E.; Rueping M.; Online monitoring and analysis for autonomous continuous flow self-optimizing reactor systems; React. Chem. Eng.; 2016; 1; 129–133

link to article

To top
Structuring hybrid palladium nanoparticles in metallic monolithic reactors for continuous-flow three-phase alkyne hydrogenation

Albani, D.; Vilé, G.; Toro, M. A. B.; Kaufmann, R.; Mitchell, S.; Ramírez-Pérez, J.; Structuring hybrid palladium nanoparticles in metallic monolithic reactors for continuous-flow three-phase alkyne hydrogenation; React. Chem. Eng.; 2016; 1; 454–462

link to article

To top
Reaction screening in continuous flow reactors

Mohamed, D. K. B.; Yu, X.; Li, J.; Wu, J.; Reaction screening in continuous flow reactors; Tetrahedron Lett.; 2016; Article ASAP

link to article

To top
HKUST-1 silica aerogel composites: novel materials for the separation of saturated and unsaturated hydrocarbons

Nuzhdin, A. L.; Shalygin, A. S.; Artiukha, E. A.; Chibiryaev, A. M.; Bukhtiyarova, G. A.; Martyanov, O. N.; HKUST-1 silica aerogel composites: novel materials for the separation of saturated and unsaturated hydrocarbons by conventional liquid chromatography; RSC Adv.; 2016; 6; 62501-62507

link to article

To top

Tan, G. Y.; Zhu, F.; Deng, Z.; Liu, T.; In vitro reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors; Synthetic and Systems Biotechnology; 2016; 1; 25–33

link to article

To top
 Preparation of vinyl ethers using a Wittig approach, and their subsequent hydrogenation employing continuous-flow processing

Balti, M.; Efrit, M. L.; Leadbeater, N. E.; Preparation of vinyl ethers using a Wittig approach, and their subsequent hydrogenation employing continuous-flow processing; Tetrahedron Lett.; 2016; 57; 1804-1806

link to article

To top

Franzen, R. G.; Metathesis Reactions on Solid-Phase: Towards New Synthesis Challenges; Top Catal; 2016; 59; 1143-1150

link to article

To top

Finelli, F. G.; Miranda, L. S. M.;  de Souza, R. O. M. A.; Expanding the toolbox of asymmetric organocatalysis by continuous-flow process; Chem. Commun.; 2015; 51; 3708-3722

link to article

To top
Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies

Bach, A.; Pizzirani, D.; Realini, N.; Vozella, V.; Russo, D.; Penna, I.; Melzig, L.; Scarpelli, R.; Piomelli, D.; Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies; J. Med. Chem., 2015, 58 (23), 9258–9272

link to article

To top

Chandra, T.; Zebrowski; J. P.; Hazards associated with laboratory scale hydrogenations; Journal of Chemical Health and Safety; Available online 2 November 2015

link to article

To top
Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides

Furlotti, G.; Alisi, M. A.; Cazzolla, N.; Dragone, P.; Durando, L.; Magarò, G.; Mancini, F.; Mangano, G.; Ombrato, R.; Vitiello, M.; Armirotti, A.; Capurro, V.; Lanfranco, M.; Ottonello, G.; Summa, M.; Reggiani, A.; Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders; J. Med. Chem.; 2015; 58 (22); 8920–8937

link to article

To top
Preclinical Characterization of the FAAH Inhibitor JNJ-42165279

Keith, J. M.; Jones, W. M.; Tichenor, M.; Liu, J.; Seierstad, M.; Palmer, J. A.; Webb, M.; Karbarz, M.; Scott, B. P.; Wilson, S. J.; Luo, L.; Wennerholm, M. L.; Chang, L.; Rizzolio, M.; Rynberg, R.;Chaplan, S. R.; Breitenbucher, J. G.; Preclinical Characterization of the FAAH Inhibitor JNJ-42165279; ACS Med. Chem. Lett.; 2015; 6 (12); 1204–1208

link to aticle

To top
Synthesis, Biological Evaluation and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor

Schembri, L. S.; Stoddart, L. A.; Briddon, S. J.; Kellam, B.; Canals, M.; Graham, B.; Scammells, P. J.; Synthesis, Biological Evaluation and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor; J. Med. Chem.; 2015; 58 (24); 9754–9767

link to article

To top

Budhadev, D.; Mukhopadhyay, B.; Convergent synthesis of the hexasaccharide related to the repeating unit of the O-antigen from E. coli O120; RSC Adv.; 2015; 5; 98033-98040

link to article

To top

Kovács, L.; Szőllősi, G.; Fülöp, F.; Pt-cinchonidine catalyzed asymmetric catalytic cascade reaction of 2-nitrophenylpyruvates in flow system; Journal of Flow Chemistry2015; 5(4); 210-215

link to article

To top

Ricciardi, R.; Huskens, J.; Verboom, W.; Nanocatalysis in Flow; ChemSusChem2015; 8(16); 2586-2605

link to article

To top

Lövei, K.; Greiner, I.; Éles, J.; Szigetvári, Á.; Dékány, M.; Lévai, S.; Novák, Z.; Túrós, I. Gy.; Multistep Continuous-Flow Synthesis of Condensed Benzothiazoles; Journal of Flow Chemistry; 2015; 5(2); 74-81

link to article

To top
Valorization of lignin waste from hydrothermal treatment of biomass

Chieffti, G.; Fechler, N.; Esposito, D.; Valorization of lignin waste from hydrothermal treatment of biomass: towards porous carbonaceous composites for continuous hydrogenation; RSC Advances; 2015; 5(78); 63691-63696

link to article

To top

Leão, C. A. R.; de O. Lopes, R.; de M. Bezerra, de M. A.; Muniz, M. N.; Casanova, B. B.; Gnoatto, S. C. B.; Gosmann, G.; Kocsis, L.; de Souza, R. O. M. A.; de M. Miranda, L. S.; Studies on the Continuous-Flow Synthesis of Nonpeptidal bis-Tetrahydrofuran Moiety of Darunavir; Journal of Flow Chemistry; 2015; 5(4); 216-219

link to article

To top
Synthesis of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease

Alexandre, F.Brandt, G.Caillet, C.Chaves, D.Convard, T.Derock, M.; Gloux, D.Griffon, Y.; Lallos, L.; Leroy, F.; Liuzzi, M.; Loi, A.Moulat, L.; Musiu, C.; Parsy, C.; Rahali, H.; Roques, V.; Seifer, M.; Standring, D.; Surleraux, D.; Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease; Bioorganic & Medicinal Chemistry Letters; 2015; 25(18); 3984-3991

link to article

To top
Optimization of Novel Indazoles for the Treatment of Respiratory Disease

Down, K.; Amour, A.; Baldwin, I. R.; Cooper, A. W. J.; Deakin, A. M.; Felton, L. M.; Guntrip, S. B.; Hardy, C.; Harrison, Z. A.; Jones, K. L.; Jones, P.; Keeling, S. E.; Le, J.; Livia, S.; Lucas, F.; Lunniss, C. J.; Parr, N. J.; Robinson, E.; Rowland, P.; Smith, S.; Thomas, D. A.; Vitulli, G.; Washio, Y.; Hamblin, J. N.; Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease; Journal of  Medicinal Chemistry; 2015; 58(18); 7381-7399

link to article

To top
Enantiodivergent Synthesis of Bis-Spiropyrrolidines via Sequential Interrupted and Completed (3 + 2) Cycloadditions

Conde, E.; Rivilla, I.; Larumbe, A.; Cossío F. P.; Enantiodivergent Synthesis of Bis-Spiropyrrolidines via Sequential Interrupted and Completed (3 + 2) Cycloadditions; Journal of Organic Chemistry; 2015; 80(23); 11755-11767

link to article

To top
Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors

Bamborough, P.; Chung, C.; Furze, R. C.; Grandi, P.; Michon, A.; Sheppard, R. J.; Barnett, H.; Diallo, H.; Dixon, D. P.; Douault, C.; Jones, E. J.; Karamshi, B.; Mitchell, D. J.; Prinjha, R. K.; Rau, C.; Watson, R. J.; Werner, T.; Demont, E. H.; Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors; Journal of Medicinal Chemistry; 2015; 58(15); 6151-6178

link to article

To top
  The expanding utility of continuous flow hydrogenation

Cossar, P. J.; Hizartzidis, L.; Simone, M. I.; McCluskey A.; Gordon, C. P.; The expanding utility of continuous flow hydrogenation; Organic & Biomulecular Chemistry2015; 13; 7119-7130

link to article

To top
Synthesis of the Trisaccharide Repeating Unit of the Lipopolysaccharide from Moritella viscosa Strain M2-226

Pal, K. B.; Verma, P. R.; Gupta, T.; Mukhopadhyay, B.; Synthesis of the Trisaccharide Repeating Unit of the Lipopolysaccharide from Moritella viscosa Strain M2-226; Journal of Carbohydrate Chemistry; 2015; 34(4); 173–182

link to article

To top


Vaddula, B. R.; Yalla, S.; Gonzalez, M. A.; An efficient and more sustainable one-step continuous-flow multicomponent synthesis approach to chromene derivatives; Journal of Flow Chemistry; 2015; 5(3); 172-177

link to article

To top


Calle, L. P.; Echeverria, B.; Franconetti, A.; Serna, S.; Fernández-Alonso, M. C.; Diercks, T.; Cañada, F. J.; Ardá, A.; Reichardt, N. C.; Jiménez-Barbero, J.; Monitoring Glycan–Protein Interactions by NMR Spectroscopic Analysis: A Simple Chemical Tag That Mimics Natural CH–π Interactions; Chemistry; 2015; 21(32); 11408-11416

link to article

To top
Structural Identification of Petroleum Acids by Conversion to Hydrocarbons and Multidimensional GC-MS

Wilde, M. J.; Rowland S. J.; Structural Identification of Petroleum Acids by Conversion to Hydrocarbons and Multidimensional Gas Chromatography-Mass Spectrometry; Analytical Chemistry; 2015; 87(16); 8457-8465

link to article

To top

Nuzhdin, A. L.; Moroz, B. L.; Bukhtiyarova, G. A.; Reshetnikov, S. I.; Pyrjaev, P. A.; Aleksandrov P. V.; Bukhtiyarov, V. I.; Selective Liquid-Phase Hydrogenation of a Nitro Group in Substituted Nitrobenzenes over Au/Al2O3 Catalyst in a Packed-Bed Flow Reactor; ChemPlusChem; 2015; 80(12); 1741-1749

link to article

To top


Yadav, J. S.; Suresh, B.; Srihari, P.; Stereoselective Total Synthesis of the Marine Macrolide Sanctolide A; European Journal of Organic Chemistry; 2015; 2015(26); 5856-5863

link to article

To top
Synthesis of the Tetrasaccharide Repeating Unit of the β-Kdo-Containing Exopolysaccharide


Laroussarie, A.; Barycza, B.; Andriamboavonjy, H.; Kenfack, M. T.; Blériot, Y.; Gauthier, C.; Synthesis of the Tetrasaccharide Repeating Unit of the β-Kdo-Containing Exopolysaccharide from Burkholderia pseudomallei and B. cepacia Complex; The Journal of Organic Chemistry; 2015; 80(20); 10386-10396

link to article

To top

Chieffi, G.; Braun, M.; Esposito, D.; Continuous Reductive Amination of Biomass-Derived Molecules over Carbonized Filter Paper-Supported FeNi Alloy; ChemSusChem; 2015; 8(21); 3590-3594

link to article

To top

Luska, L. K.; Migowski, P.; Sayed, E. S.; Leitner, W.; Synergistic Interaction within Bifunctional Ruthenium Nanoparticle/SILP Catalysts for the Selective Hydrodeoxygenation of Phenols; Angewandte Chemie; 2015; 127(52); 15976–15981

link to article

To top
Diversity-Oriented Synthesis of a Library of Star-Shaped 2H‑Imidazolines

Yu, X.; Guttenberger, N.; Fuchs, E.; Peters, M.; Weber, H.; Breinbauer R.; Diversity-Oriented Synthesis of a Library of Star-Shaped
2H‑Imidazolines; ACS Combinatorial Science; 2015; 17(11); 682-690

link to article

To top

Russell, C.; Lin, A. J. S.; Hains, P.; Simone, M. I.; Robinson, P. J.; McCluskey, A.; An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor; RSC Advances; 2015; 5; 93433-93437

link to article

To top
Continuous flow hydrogenation of nitroarenes, azides and alkenes using maghemite-Pd nanocomposites

Rathi, A. K.; Gawande, M. B.; Ranc, V.; Pechousek, J.; Petr, M.; Cepe, K.; Varma, R. S.; Zboril, R.; Continuous flow hydrogenation of nitroarenes, azides and alkenes using maghemite-Pd nanocomposites; Catalysis Science & Technology; 2015; 6, 152-160

link to article

To top
Diels–Alder Reaction of 1,3-Diene-1-carbamates Catalyzed by Chiral Phosphoric Acids

Pous, J.; Courant, T.; Bernadat, G.; Iorga, B. I.; Blanchard, F.; Masson, G.; Regio-, Diastereo-, and Enantioselective Nitroso-Diels–Alder Reaction of 1,3-Diene-1-carbamates Catalyzed by Chiral Phosphoric Acids; Journal of the American Chemical Society; 2015; 137 (37); 11950–11953

link to article

To top
Improved and scalable synthesis of building blocks for the modular synthesis of teraryl-based alpha-helix mimetics

Trobe, M.; Breinbauer, R.; Improved and scalable synthesis of building blocks for the modular synthesis of teraryl-based alpha-helix mimetics; Monatsh Chem; 2015; 147 (3); 509-521

link to article

To top
Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents

Ng, P. S.;Manjunatha, U. H.; Rao, S. P. S.; Camacho, L. R.; Ma, N. L.; Herve, M.; Noble, C. G.; Goh, A.; Peukert, S.; Diagana, T. T.; Smith, P. W.; Kondreddi, R. R.; Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents; European Journal of Medicinal Chemistry; 2015; 106; 144-156

link to article

To top
1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activity


Abdel-Hamid, M. K.; Macgregor, K. A.; Odell, L. R.; Chau, N.; Mariana, A.; Whiting, A.; Robinson, P. J.; McCluskey, A.; 1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activity; Organic & Biomolecular Chemistry; 2015; 13(29); 8016-8028

link to article

To top

Wulandari, M.; Urraca, J. L.; Descalzo, A. B.; Amran, M. B.; Moreno-Bondi, M. C.; Molecularly imprinted polymers for leanup and selective extraction of curcuminoids in medicinal herbal extracts; Analytical and Bioanalytical Chemistry; 2015; 407(3); 803-812

link to article

To top
Synthesis of 13C Labeled Complex N-Glycans As Internal Standards for the Absolute Glycan Quantification by MS

Echeverria, B.; Etxebarria, J.; Ruiz, N.; Hernandez, A.; Calvo, J.; Haberger, M.; Reusch, D.; Reichardt, N-C.; Chemo-Enzymatic Synthesis of 13C Labeled Complex N-Glycans As Internal Standards for the Absolute Glycan Quantification by Mass Spectrometry; Analytical Chemistry; 2015; 87(22); 11460-11467

link to article

To top
One-pot reductive amination of aldehydes with nitroarenes over an Au/Al2O3 catalyst in a continuous flow reactor

Artiukha, E. A.; Nuzhdin, A. L.; Bukhtiyarova, G. A.; Zaytsev, S. Yu.; Plyusnin, P. E.; Shubinbc, Yu. V.; Bukhtiyarov, V. I.; One-pot reductive amination of aldehydes with nitroarenes over an Au/Al2O3 catalyst in a continuous flow reactor; The Royal Society of Chemistry; 2015; 5(10); 4741-4745

link to article

To top
Densely Substituted l-Proline Esters as Catalysts for Asymmetric Michael Additions of Ketones to Nitroalkenes

Ruiz-Olalla, A.; de Gracia Retamosa, M.; Cossío, F. P.; Densely Substituted l-Proline Esters as Catalysts for Asymmetric Michael Additions of Ketones to Nitroalkenes; J. Org. Chem.; 2015; 80 (11); 5588–5599

link to article

To top
Continuous-flow hydrogenation of olefins and nitrobenzenes catalyzed by platinum nanoparticles

Osako, T.; Torii, K.; Tazawaa, A.; Uozumi, Y.; Continuous-flow hydrogenation of olefins and nitrobenzenes catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer; RSC Adv.; 2015; 5; 45760-45766

link to article

To top
Structure and Reactivity of Supported Hybrid Platinum Nanoparticles for the Flow Hydrogenation of Functionalized Nitroaromatics

Vilé, G.; Almora-Barrios, N.; López, N.; Pérez-Ramírez, J.; Structure and Reactivity of Supported Hybrid Platinum Nanoparticles for the Flow Hydrogenation of Functionalized Nitroaromatics; ACS Catal.; 2015; 5(6); 3767–3778

link to article

To top
Chemical Synthesis of the Pentasaccharide Related to the Repeating Unit of the O-Antigen from Salmonella enterica O4

Das, R.; Mukhopadhyay, B.; Chemical Synthesis of the Pentasaccharide Related to the Repeating Unit of the O-Antigen from Salmonella enterica O4; Journal of Carbohydrate Chemistry; 2015; 34(5); 247-262

link to article

To top

Morales-delaRosa, S.; Campos-Martin, J. M.; Terreros, P.; Fierro, J. L. G.; Catalytic Epoxidation of Cyclohexene with Tert-butylhydroperoxide Using an Immobilized Molybdenum Catalyst; Topics in Catalysis; 2015; 58(4); 325-333

link to article

To top
Design of Experiments (DoE) and Process Optimization. A Review of Recent Publications

Weissman, S. A.; Anderson, N. G.; Design of Experiments (DoE) and Process Optimization. A Review of Recent Publications; Org. Process Res. Dev.; 2015; 19(11); 1605–1633

link to article

To top
Formation of benzocyclobutenes from substituted oxocycloocta-2,8-diene-1,2-dicarboxylates

Bezenšek, j.; Grošelj, U.; Počkaj, M.; Svete, J.; Stanovnik, B.; Formation of benzocyclobutenes from substituted oxocycloocta-2,8-diene-1,2-dicarboxylates; Tetrahedron Letters; 2015; 56(42); 5705-5708

link to article

To top
Synthesis of four (4-, 2-, 2-, and 6-) monodeoxy analogs of the trisaccharide...

Glinschert, A.; Oscarson, S.; Synthesis of four (4"-, 2"-, 2'-, and 6-) monodeoxy analogs of the trisaccharide α-D-Glcp-(1→3)-α-d-Manp-(1→2)-α-D-ManpOMe recognized by Calreticulin/Calnexin; Carbohydrate Research; 2015; 414; 65-71

link to article

To top
Total Synthesis of (±)-Taiwaniaquinol F and Related Taiwaniaquinoids

Kakde, B. N.; Kumari, P.; Bisai, A.; Total Synthesis of (±)-Taiwaniaquinol F and Related Taiwaniaquinoids; J. Org. Chem.; 2015; 80(20); 9889–9899

link to article

To top
Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

Phillipson, L. J.; Segal, D. H.; Nero, T. L.; Parker, M. W.; Wan, S. S.; Silva, M.d.; Guthridge, M. A.; Wei, A. H.; Burns, C. J.; Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9; Bioorganic & Medicinal Chemistry; 2015; 23(19); 6280-6296

link to article

To top
 Flow Chemistry: Intelligent Processing of Gas–Liquid Transformations Using a Tube-in-Tube Reactor

Brzozowski, M.; O’Brien, M.; Ley, V. S.;  Polyzos, A.; Flow Chemistry: Intelligent Processing of Gas–Liquid Transformations Using a Tube-in-Tube Reactor; Acc. Chem. Res.; 2015; 48(2); 349–362

link to article

To top
Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists

Savall, B. M.; Wu, D.; Angelis, M. D.; Carruhters, N. I.; Ao, H.; Wang, Q.; Lord, B.; Bharrachrya, A.; Letavic, M. A.; Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists; ACS Med. Chem. Lett.; 2015; 6; 671−676

link to article

To top

Ley, S. V.; Fitzpatrick, D. E.; Ingham, R. J.; Myers, R. M.; Organic Synthesis: March of the Machines; Angewandte Chemie; 2015; 54(11); 3449-3464

link to article

To top
One-pot tandem Suzuki cross coupling–reduction of haloacetophenones and arylboronic acids

Zhang, D.; Cheng, T.; Liu, G.; An imidazolium-based organopalladium-functionalized organic–inorganic hybrid silica promotes one-pot tandem Suzuki cross coupling–reduction of haloacetophenones and arylboronic acids; Applied Catal. B: Environmental; 2015 ; 174-175; 344-349

link to article

To top
The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

Baumann, M.; Baxendale, I. R.; The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry; Beilstein J. Org. Chem.; 2015; 11; 1194–1219

link to article

To top
Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators

Martín-Martín, M. L.; Bartolomé-Nebreda, J. M.; Conde-Ceide, S.; Alonso de Diego, S. A.; López, S.; Martínez-Viturro, C. M.; Tong, H. M.; Lavreysen, H.; Macdonald, G. J.; Steckler, T.; Mackie, C.; Bridges, T. M.; Daniels, J. S.; Niswender, C. M.; Noetzel, M.J.; Jones, C.K.; Conn, P. J.; Lindsley, C. W.; Stauffer, S. R.; Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5); Bioorg. Med. Chem. Lett.; 2015; 25(6); 1310-1317

link to artilce

To top
Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives

Bazin, H. G.; Li, Y.; Khalaf, J. K.; Mwakwari, S.; Livesay, M. T.; Evans, J. T.; Johnson, D. A.; Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives; Bioorganic & Medicinal Chemistry Letters; 2015; 25(6); 1318–1323

link to artilce

To top
The role of water in catalytic biomass-based technologies to produce chemicals and fuels

Mika, L. T.; Cséfalvay, E.; Horváth, I. T.; The role of water in catalytic biomass-based technologies to produce chemicals and fuels; Catalysis Today; 2015; 247; 33–46

link to article

To top

Suljic´, S.; Mortzfeld, F. B.; Gunne, M.; Urlacher, V. B.; Pietruszka, J.; Enhanced Biocatalytic Performance of Bacterial Laccase from Streptomyces sviceus: Application in the Michael Addition Sequence Towards 3-Arylated 4-Oxochromanes; ChemCatChem; 2015; 7; 1380 –1385

link to article

To top

Madarász, J.; Németh, D.; Bakos, J.; Gubicza, L.; Bakonyi, P.; Solvent-free enzymatic process for biolubricant production in continuous microfluidic reactor; Journal of Cleaner Production; 2015; 93; 140-144

link to article

To top
Synthesis of N-Hydroxypyrazin-2(1H)-ones via Selective O-Debenzylation of 1-Benzyloxypyrazin-2(1H)-ones

Mai, A. H.; De Borggraeve, M.; Synthesis of N-Hydroxypyrazin-2(1H)-ones via Selective O-Debenzylation of 1-Benzyloxypyrazin-2(1H)-ones Using Flow Methodology; J. Flow Chem.; 2015; 5(1); 6–10

link to article

To top

Martin, A. D.; Siamaki, A. R.; Belecki, K.; Gupton, B. F.; A Flow-Based Synthesis of Telmisartan; J. Flow Chem.; 2015; 5(3); 145–147

link to article

To top

Nieves-Remacha, M. J.; Jensen, K. F.; Mass Transfer Characteristics of Ozonolysis in Microreactors and Advanced-Flow Reactors; J. Flow Chem.; 2015; 5(3); 160–165

link to article

To top
Synthesis and Biological Evaluation of Second-Generation Tropanol-Based Androgen Receptor Modulators

Sundén, H.; Holland, M. C.; Pouiainen, P. K.; Jääskeläinen, T.; Pulkkinen, J. T.; Palvimo, J. J.; Olsson, R.; Synthesis and Biological Evaluation of Second-Generation Tropanol-Based Androgen Receptor Modulators; J. Med. Chem.; 2015; 58; 1569−1574

link to article

To top
Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain

Parsons, W. H.; Calvo, R. R.; Cheung, W.; Lee, Y. K.; Patel, S.; Liu, J.; Youngman, M. A.; Dax, S. L.; Stone, D.; Qin, N.; Hutchinson, T.; Lubin, M. L.; Zhang, S. P.; Finley, M.; Liu, Y.; Brandt, M. R.; Flores, C. M.; Player, M. R.; Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep); J. Med. Chem.; 2015; 58 (9); 3859–3874

link to article

To top
Synthetic Studies toward the C32−C46 Segment of Hemicalide. Assignment of the Relative Configuration of the C36−C42 Subunit

Specklin, S.; Boissonnat, G.; Lecourt, C.; Sorin, G.; Lannou, M. I.; Ardisson, J.; Sautel, F.; Massiot, G.; Meyer, C.; Cossy, J.; Synthetic Studies toward the C32−C46 Segment of Hemicalide. Assignment of the Relative Configuration of the C36−C42 Subunit; Org. Lett.; 2015; 17(10); 2446−2449

link to article

To top
SiliaCat: A Versatile Catalyst Series for Synthetic Organic Chemistry

Ciriminna, R.; Pandarus, V.; Fidalgo, A.; Ilharco, L. M.; Béland, F.; Pagliaro, M.; SiliaCat: A Versatile Catalyst Series for Synthetic Organic Chemistry; Org. Process Res. Dev.; 2015; 19 (7); 755–768

link to article

To top

Zaytsev, V. P.; Zubkov, F. I.; Mertsalov, D. F.; Orlova, D. N.; Sorokina, E. A.; Nikitina, E. V.; Varlamov, A. V.; Continuous-flow catalytic hydrogenation of 3a,6-epoxyisoindoles; Russian Chemical Bulletin; 2015; 64(1); 112-126

link to article

To top

Soung, M. J.; Woo, S. J.; Shin, D. J.; Safe hydrogenation of organic compounds and their property studies; Youth Scientist Journal; 2015; 7(1); 45-53

link to article

To top
Flow chemistry as a versatile tool for the synthesis of triazoles

Ötvös, S. B.; Fülöp, F.; Flow chemistry as a versatile tool for the synthesis of triazoles; Catal. Sci. Technol.; 2015; 5(11); 4926-4941

link to article

To top
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition

Colley, H. E.; Muthana, M.; Danson, J. S.; Jackson, L. V.; Brett, M. L.; Harrison, J.; Coole, S. F.; Mason, D. P.; Jennings, L. R.; Wong, M.; Tulasi, V.; Noraman, D.; Lockey, P. M.; Williams, L.; Dossetter, A. G.; Griffen, E. J.; Thompson, M. J.; An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer; J. Med. Chem.; 2015; 58(23); 9309–9333

link to article

To top

Bergeron-Brlek, M.; Meanwell, M.; Britton, R.; Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars; Nature Communications; 2015; 6; 1-11

link to article

To top
Aerobic flow oxidation of alcohols in water catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

Osako, T.; Toriia, K.; Uozumi, Y.; Aerobic flow oxidation of alcohols in water catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer; RSC Adv.; 2015; 5; 2647-2654

link to article

To top
Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models

Patel, S.; Cohen, F.; Dean, B. J.; De La Torre, K.; Deshmukh, G.; Estrada, A. A.; Ghosh, A. S.; Gibbons, P.; Gustafson, A.; Huestis, M. P.; Le Pichon, C. E.; Lin, H.; Liu, W.; Liu, X.; Liu, Y.; Ly, C. Q.; Lyssikatos, J. P.; Ma, C.; Scearce-Levie, K.; Shin, Y. G.; Solanoy, H.; Stark, K. L.; Wang, J.; Wang, B:; Zhao, X.; Lewcock, J. W.; Siu, M.; Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models; J. Med. Chem.; 2015; 58 (1); 401-418

link to article

To top

Ricko, S.; Golobic, A.; Svete, J.; Stanovnik, B.; Groselj, U.; Synthesis of Novel Camphor-Derived Bifunctional Thiourea; Chirality; 2015; 27 (1); 39-52

link to article

To top
Facile access to new C-glycosides and C-glycoside scaffolds incorporating functionalised aromatic moieties

Redpath, P.; Ness, K. A.; Rousseau, J.; Macdonald, S. J. F.; Migaud, M. E.; Facile access to new C-glycosides and C-glycoside scaffolds incorporating functionalised aromatic moieties; Carbohydrate Research; 2015; 402; 25–34

link to article

To top

Hsieh, C.; Otvos, S. B.; Wu, Y.; Mandity, I. M.; Chang, F.; Fulop, F.; Highly Selective Continuous-Flow Synthesis of Potentially Bioactive Deuterated Chalcone Derivatives; ChemPlusChem; 2015; 80(5); 859-864

link to article

To top
A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

Viviano, M.; Milite, C.; Rescigno, D.; Castellano, S.; Sbardella, G.; A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery; RSC Adv.; 2015; 5; 1268-1273

link to article

To top

Wilde, M. J.; West, C. E.; Scarlett, A. G.; Jones, D.; Frank, R. A.; Hewitt, L. M.; Rowland, S. J.; Bicyclic naphthenic acids in oil sands process water: Identification bycomprehensive multidimensional gas chromatography–massspectrometry; Journal of Chromatography A; 2015; 13; 74–87

link to article

To top
Iridium(I)-Catalyzed Ortho-Directed Hydrogen Isotope Exchange in Continuous-Flow Reactors

Habraken, E. R. M.; Haspeslagh, P.; Vliegen, M.; Noel, T.; Iridium(I)-Catalyzed Ortho-Directed Hydrogen Isotope Exchange in Continuous-Flow Reactors; Journal of Flow Chemistry; 2015; 5 (1); 2-5

link to article

To top
Identification of a Novel Orally Bioavailable Phosphodiesterase 10A Inhibitor with Efficacy in Animal Models of Schizophrenia

Bartolomee-Nebreda, J. M.; de Diego, S. A. A.; Artola, M.; Delgado, F.; Delgado, O.; Martin-Martin, M. L.; Martinez-Viturro, C. M.; Pena, M. A.; Tong, H. M.; Gool, M. V.; Alonso, J. M.; Fontana, A.; Macdonald, G. J.; Megens, A.; Langlois, X.; Somers, M.; Vanhoof, G.; Conde-Ceide, S.; Identification of a Novel Orally Bioavailable Phosphodiesterase 10A (PDE10A) Inhibitor with Efficacy in Animal Models of Schizophrenia; J. Med. Chem.; 2015; 58 (2); 978–993

link to article

To top

Lengyel, L.; Sipos, G.; Sipocz, T.; Vago, T.; Dorman, Gy.; Gerencser, J.; Makara, G.; Darvas, F.; Synthesis of Condensed Heterocycles by the Gould−Jacobs Reaction in a Novel Three-Mode Pyrolysis Reactor; Org. Process Res. Dev.; 2015; 19 (3); 399–409

link to article

To top

Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction; Liu, Q.; Wu, K.; Cheng, Y., Lu, L.; Xiao, E.; Zhang, Y.; Deng, Z.; Liu, T.; Metabolic Engineering; 2015; 28; 82-90

link to article

To top

Hattori, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous Flow System; Catalysts; 2015; 5; 18-25

link to article

To top

Greco, R.; Goessler, W.; Cantillo, D.; Kappe, C. O.; Benchmarking Immobilized Di- and Triarylphosphine Palladium Catalysts for Continuous-Flow Cross-Coupling Reactions: Efficiency, Durability, and Metal Leaching Studies; ACS Catal.; 2015; 5; 1303-1312

link to article

To top
Alkyl–Aryl Negishi Cross-Coupling in Flow: Mild, Efficient and Clean Introduction of Functionalized Alkyl Groups

Egle, B.; Muñoz, J. M.; Alonso, N.; De Borggraeve, W. M., Hoz, A.; Díaz-Ortiz, A.; Alcázar1, J.; First Example of AlkylAryl Negishi Cross-Coupling in Flow: Mild, Efficient and Clean Introduction of Functionalized Alkyl Groups; J. Flow Chem.; 2014; 4 (1); 22-25

DOI 10.1556/JFC-D-13-00009

Link to article

To top
Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Cummings, M. D.; Lin, T.; Hu, L.; Tahri, A.; McDowan, D.; Amssoms, K.; Last, S.; Devogelaere, B., Rouan, M.; Vijgen, L., Berke, J. M.; Dehertogh, P.; Fransen, E.; Cleiren, E.; van der Helm, L.; Fanning, G.; Nyanguile, O.; Simmen, K.; Remoortere, P. V.; Raboisson, P.; Vendeville, S., Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase; J. Med. Chem.; 2014; 57 (5); 1880-1892

DOI: 10.1021/jm401396p

Link to article

To top
Synthesis and Structure–Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives

Luci, D. K.; Jameson, J. B.; Yasgar, A.; Diaz, G.; Joshi, N.; Kantz, A.; Markham, K., Perry, S.; Kuhn, N.; Yeung, J., Kerns, E. H.; Schultz, L.; Holinstat, M.; Nadler, J. L.; Taylor-Fishwick, D. A.; Jadhav, A.; Simeonov, A.; Holman, T. R.; Maloney, D. J.; Synthesis and Structure–Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase; J. Med. Chem.; 2014; 57 (2); 495-506

DOI: 10.1021/jm4016476

Link to article

To top
Synthesis of 3-Arylated 3,4-Dihydrocoumarins: Combining Continuous Flow Hydrogenation with Laccase-Catalysed Oxidation

Suljic, S.; Pietruszka, J.; Synthesis of 3-Arylated 3,4-Dihydrocoumarins: Combining Continuous Flow Hydrogenation with Laccase-Catalysed Oxidation; Adv. Synth. Catal.; 2014; 356; 1007–1020

DOI: 10.1002/adsc.201300990

Link to article

To top
Synthesis of TAIW from TADBIW by Catalytic Hydrogenolysis Using a Continuous Flow Process

Dong, K.;Sun, C. H.; Song, J. W., Wei, G. X.; Pang, S. P.; Synthesis of 2,6,8,12-Tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane (TAIW) from 2,6,8,12-Tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazaisowurtzitane (TADBIW) by Catalytic Hydrogenolysis Using a Continuous Flow Process; OPRD; 2014; Article ASAP

DOI: 10.1021/op500020d

Link to article

To top

Fiasella, A.; Nuzzi, A.; Summa, M.; Armirotti, A.; Tarozzo, G.; Tarzia, G.; Mor, M.; Bertozzi, F.; Bandiera, T.; Piomelli, D.; 3-Aminoazetidin-2-one Derivatives as N-Acylethanolamine Acid Amidase (NAAA) Inhibitors Suitable for Systemic Administration; ChemMedChem; 2014; Early view

DOI: 10.1002/cmdc.201300546

Link to article

To top

Pataj, Z.; Ilisz, I.; Grecsó, N; Palkó, M.; Fülöp, F.; Armstrong, D. W.; Péter, A.; Enantiomeric Separation of Bicyclo[2.2.2]octane-Based 2-Amino-3-Carboxylic Acids on Macrocyclic Glycopeptide Chiral Stationary Phases; Chirality; 2014; 26; 200-208

DOI: 10.1002/chir.22301

Link to article

To top
Evaluation dynamic kinetic resolution strategies in the asymmetric hydrosilylation of cyclic ketimines

Jones, S.; Zhao, P.; Evaluation dynamic kinetic resolution strategies in the asymmetric hydrosilylation of cyclic ketimines; Tetrahedron: Asymmetry; 2014; 25(3); 238–244

DOI: 10.1016/j.tetasy.2013.11.006

Link to article

To top
Measurement of supramolecular effective molarities for intramolecular H-bonds in zinc porphyrin–imidazole complexes

Jinks, M. A.; Sun, H.; Hunter, C. A.; Measurement of supramolecular effective molarities for intramolecular H-bonds in zinc porphyrin–imidazole complexes; Org. Biomol. Chem.; 2014; 12; 1440-1447

DOI: 10.1039/C3OB42246A

Link to article

To top
Synthesis of an azabicyclic framework towards (±)-actinophyllic acid

Mortimer, D.; Whiting, M.; Harrity, J. P. A.; Jones, S.; Coldham, I.; Synthesis of an azabicyclic framework towards (±)-actinophyllic acid; Tetrahedron Letters; 2014; 55; 1255–1257

DOI: 10.1016/j.tetlet.2014.01.019

Link to article

To top
Chemistry of pyrrolizidine alkaloids revisited

Martineza, S. T.; Pinto, A. C.; Glasnov, T.; Kappe, C. O.; Chemistry of pyrrolizidine alkaloids revisited – semi-synthetic microwave and continuous-flow approaches towards Crotalaria-alkaloids; Tetrahedron Letters; 2014; 55(30); 4181-4184

Link to article

To top
Systematic evaluation of the palladium-catalyzed hydrogenation under flow conditions

Hattori, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Systematic evaluation of the palladium-catalyzed hydrogenation under flow conditions; Tetrahedron; 2014; 70 (32); 4790–4798

DOI: 10.1016/j.tet.2014.05.038

Link to article

To top

Leese, M. P.; Jourdan, F. L.; Major, M. R.; Dohle, W.; Thomas, M. P.; Hamel, E.; Ferrandis, E.; Mahon, M. F.; Newman, S. P.; Purohit, A.; Potter, B. V. L.; Synthesis, Anti-tubulin and Antiproliferative SAR of Steroidomimetic Dihydroisoquinolinones; ChemMedChem; 2014; 9; 798–812

DOI: 10.1002/cmdc.201400017

Link to article

To top
Flash carboxylation: fast lithiation–carboxylation sequence at room temperature in continuous flow

Pieber, B.; Glasnov, T.; Kappe, C. O..; Flash carboxylation: fast lithiation–carboxylation sequence at room temperature in continuous flow; RSC Adv.; 2014; 4; 13430–13433

DOI: 10.1039/C4RA01442A

Link to article

To top
Fully Automated Sequence-Specific Synthesis of α-Peptides Using Flow Chemistry

Knudsen, K. R.; Ladlow, M.; Bandpey, Z.; Ley, S. V.; Fully Automated Sequence-Specific Synthesis of α-Peptides Using Flow Chemistry; J. Flow Chem.; 2014; 4(1); 18–21

DOI: 10.1556/JFC-D-13-00033

Link to article

To top
Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ‑Secretase Modulators

Pettersson, M.; Johnson, D. S.; Subramanyam, C.; Bales, K. R.; am Ende, C. W.; Fish, B. A.; Green, M. E.; Kauffman, G. W.; Mullins, P. B.; Navaratnam, T.; Sakya, S. M.; Stiff, C. M.; Tran, T. P.; Xie, L.; Zhang, L.; Pustilnik, L. R.; Vetelino, B. C.; Wood, K. M.; Pozdnyakov, N.; Verhoest, P. R.; O’Donnell. C. J.; Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ‑Secretase Modulators; J. Med. Chem.; 2014; 57; 1046−1062

DOI: 10.1021/jm401782h

Link to article

To top
Hepatitis C Virus NS5A Replication Complex Inhibitors

Belema, M.; Nguyen, V. N.; Romine, J. L.; St. Laurent, D. R.; Lopez, O. D.; Goodrich, J. T.; Nower, P. T.; O’Boyle, D. R.; Lemm, J. A.; Fridell, R. A.; Gao, M.; Fang, H.; Krause, R. G.; Wang, Y.; Oliver, A. J.; Good, A. C.; Knipe, J. O.; Meanwell, N. A.; Snyder, L. B.; Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons; J. Med. Chem.; 2014; 57; 1995−2012

DOI: 10.1021/jm4016203

Link to article

To top
Titanium Nitride-Nickel Nanocomposite as Heterogeneous Catalyst for the Hydrogenolysis of Aryl Ethers

Molinari, V.; Giordano, C.; Antonietti, M.; Esposito, D.; Titanium Nitride-Nickel Nanocomposite as Heterogeneous Catalyst for the Hydrogenolysis of Aryl Ethers; J. Am. Chem. Soc.; 2014; 136; 1758−1761

DOI: 10.1021/ja4119412

Link to article

To top

Dohle, W.; Leese, M. P.; Jourdan, F. L.; Major, M. R.; Bai, R.; Hamel, E.; Ferrandis, E.; Kasprzyk, P. G.; Fiore, A.; Newman, S. P.; Purohit, A.; Potter, B. V. L.; Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1-Substituted Tetrahydroisoquinolines; ChemMedChem; 2014; 9; 350 – 370

DOI: 10.1002/cmdc.201300412

Link to article

To top

Vitale, R.; Ottonello, G.; Petracca, R.; Bertozzi, S. M.; Ponzano, S.; Armirotti, A.; Berteotti, A.; Dionisi, M.; Cavalli, A.; Piomelli, D.; Bandiera, T.; Bertozzi, F.; Synthesis, Structure–Activity, and Structure–Stability Relationships of 2-Substituted-N-(4-oxo-3-oxetanyl) N-Acylethanolamine Acid Amidase (NAAA) Inhibitors; ChemMedChem; 2014; 9; 323–336

DOI: 10.1002/cmdc.201300416

Link to article

To top

Ingham, R. J.; Battilocchio, C.; Hawkins, J. M.; Ley, S. V.; Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide; Beilstein J. Org. Chem.; 2014; 10; 641–652

DOI: 10.3762/bjoc.10.56

Link to article

To top
Green and scalable procedure for extremely fast ligandless Suzuki-Miyaura cross-coupling reactions in aqueous IPA

Mateos, C.; Rincón, H. A.; Martín-Hidalgo, B.; Villanueva, J.; Green and scalable procedure for extremely fast ligandless Suzuki-Miyaura cross-coupling reactions in aqueous IPA using solid-supported Pd in continuous flow; Tetrahedron Letters; 2014; 55 (27); 3701–3705

DOI: 10.1016/j.tetlet.2014.05.010

Link to article

To top

Vilé, G.; Almora-Barrios, N.; Mitchell, S.; López, N.; Pérez-Ramírez, J.; From the Lindlar Catalyst to Supported Ligand-Modified Palladium Nanoparticles: Selectivity Patterns and Accessibility Constraints in the Continuous-Flow Three-Phase Hydrogenation of Acetylenic Compounds; Chem. Eur. J.; 2014; 20; 5926 – 5937

DOI: 10.1002/chem.201304795

Link to article

To top
Eco-efficiency Analysis for Intensified Production of an Active Pharmaceutical Ingredient: A Case Study

Denčić, I.; Ott, D.; Kralisch, D.; Noël, T.; Meuldijk, J.; de Croon, M.; Hessel, V.; Laribi, Y.; Perrichon, P.; Eco-efficiency Analysis for Intensified Production of an Active Pharmaceutical Ingredient: A Case Study; OPRD; 2014; Article ASAP

DOI: 10.1021/op5000573

Link to article

To top
Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labeling

Baer, S.; Nigro, J.; Madej, M. P.; Nisbet, R.M.; Suryadinata, R.; Coia, G.; Hong, L. P. T.; Adams, T. E.; Williams, C. C.; Nuttall, S. D.; Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labeling; Org. Biomol. Chem.; 2014; 12; 2675–2685

DOI: 10.1039/C3OB42325E

Link to article

To top
Chemoselective flow hydrogenation approaches to isoindole-7-carboxylic acids and 7-oxa-bicyclio [2.2.1]heptanes

Hizartzidis, L.; Tarleton, M.; Gordon, C. P.; McCluskey, A.; Chemoselective flow hydrogenation approaches to isoindole-7-carboxylic acids and 7-oxa-bicyclio [2.2.1]heptanes; RSC Adv.; 2014; 4; 9709–9722

DOI: 10.1039/C3RA47657J

Link to article

To top

Vilé, G.; Wrabetz, S.; Floryan, L.; Schuster, M. E.; Girgsdies, F.; Teschner, D.; Pérez-Ramírez, J., Stereo- and Chemoselective Character of Supported CeO2 Catalysts for Continuous-Flow Three-Phase Alkyne Hydrogenation; ChemCatChem; 2014; Early view

DOI: 10.1002/cctc.201402124

Link to article

To top

Clavel, G.; Molinari, V.; Kraupner, A.; Giordano, C.; Easy Access to Ni3N– and Ni–Carbon Nanocomposite Catalysts; Chem. Eur. J.; 2014; 20 (29); 9018-9023

DOI: 10.1002/chem.201400398

Link to article

To top

Chieffi, G.; Giordano, C.; Antonietti, M.; Esposito, D.; FeNi nanoparticles with carbon armor as sustainable hydrogenation catalyst: towards biorefineries; Journal of Materials Chemistry A; 2014; Accepted Manuscript

DOI: 10.1039/C4TA02457E

Link to article

To top

Budhadev, D.; Mukhopadhyay, B.; Chemical synthesis of a tetrasaccharide related to the exocellular polysaccharide from Rhodococcus sp. RHA1; Carbohydrate Research; 2014; Accepted Manuscript

DOI: 10.1016/j.carres.2014.05.018

Link to article

To top

Ramesh, S.; Cherkupally, P.; de la Torre, B. G.; Govender, T.; Kruger, H.G.; Albericio, F. Microreactors for peptide synthesis: looking through the eyes of twenty first century!!!; Amino Acids; 2014; 46; 2091–2104

Link to article

To top
Synthesis of the tetrasaccharide repeating unit of the O-glycan

Pal, K, B.; Mukhopadhyay, B.; Synthesis of the tetrasaccharide repeating unit of the O-glycan from the polar flagellum flagellin of Azospirillum brasilense Sp7, Carbohydrate Research; 2014; 400; 9-13

Link to article

To top

Redwan, I. N.; Dyrager, C.; Solano, C.; de Troconiz, G. F.; Voisin, L.; Bliman, D.; Meloche, S.; Grøtli, M.; Towards the development of chromone-based MEK1/2 modulators; European Journal of Medicinal Chemistry; 2014; 85; 127-138

Link to article

 

To top
Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations

Baumann, M.; Baxendale, I. R.; Hornung, C. H.; Ley, S. V.; Rojo, M. V; Roper, K. A.; Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations; Molecules; 2014; 19; 9736-9759

link to article

To top
Beyond the use of modifiers in selective alkyne hydrogenation: silver and gold nanocatalysts in flow mode

Vile, G.; Perez-Ramırez, J.; Beyond the use of modifiers in selective alkyne hydrogenation: silver and gold nanocatalysts in flow mode for sustainable alkene production; Nanoscale; 2014; 6;13476-13482

link to article

To top
Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks

Wlochal, J.; Davies, R. D. M.; Burton, J.; Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks; Org. Lett.; 2014; 16, 4094−4097

link to article

To top
SAR216471, a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist

Boldron, C.; Besse, A.; Bordes, M.; Tissandié, S.; Yvon, X.; Gau, B.; Badorc, A.; Rousseaux, T.; Barré, G.; Meneyrol, J.; Zech, G.; Nazare, M.; Fossey, V.; Pflieger, A.; Bonnet-Lignon, S.; Millet,L.; Briot, C.; Dol, F.; Hérault, J.; Savi, P.; Lassalle, G.; Delesque, N.; Herbert, J.; Bono, F.; N-[6-(4-Butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist; J. Med. Chem.; 2014; 57 (17); 7293–7316

link to article

To top

Lichtenecker, R. J.; Synthesis of aromatic 13C/2H-α-ketoacid precursors to be used in selective phenylalanine and tyrosine protein labelling; Org. Biomol. Chem.; 2014; 12; 7551-7560

link to article

To top

Martinand-Lurin, E.; El Kaïm, L.; Grimaud, L.; Benzoxazinone synthesis via Passerini–Smiles couplings; Tetrahedron Letters; 2014; 55; 5144–5146

link to article

To top

Kumar, V.; Giri, S. K.; Venugopalan, P.; Kartha, K. P. R.; Synthesis of Cross-Linked Glycopeptides and Ureas by a Mechanochemical, Solvent-Free Reaction and Determination of Their Structural Properties by TEM and X-ray Crystallography; ChemPlusChem; 2014; 79 (11); 1605 - 1613

link to article

To top
Synthesis, Biological Evaluation, and Molecular Modeling of New PDE4D Inhibitors

Brullo, C.; Massa, M.; Rocca, M; Rotolo, C.; Guariento, S.; Rivera, D.; Ricciarelli, R.; Fedele, E.; Fossa, P.; Bruno, O.; Synthesis, Biological Evaluation, and Molecular Modeling of New 3‑(Cyclopentyloxy)-4-methoxybenzaldehyde O‑(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors; J. Med. Chem.; 2014; 57 (16); 7061–7072

link to article

To top

Szakonyi, Zs.; Gonda, T.; Ötvös, S. B.; Fülöp, F.; Stereoselective syntheses and transformations of chiral 1,3-aminoalcohols and 1,3-diols derived from nopinone; Tetrahedron: Asymmetry; 2014; 25; 1138–1145

link to article

To top

Moghaddam, M. M.; Pieber, B.; Glasnov, T.; Kappe, C. O.; Immobilized Iron Oxide Nanoparticles as Stable and Reusable Catalysts for Hydrazine-Mediated Nitro Reductions in Continuous Flow; ChemSusChem; 2014; 7(11); 3122-3131

link to article

To top

Verho, O.; Gustafson, K. P. J.; Nagendiran, A.; Tai, C.; Backvall, J.; Mild and Selective Hydrogenation of Nitro Compounds using Palladium Nanoparticles Supported on Amino- Functionalized Mesocellular Foam; ChemCatChem; 2014; 6; 3153 – 3159

link to article

To top

Liguoria, F.; Barbaroa, P.; Sawaba, H.; Continuous flow hydrogenation reactions by Pd catalysts onto hybridZrO2/PVA materials; Applied Catalysis A: General; 2014; 488; 58–65

link to article

To top
Synthesis of α‑Substituted Vinylsulfonium Salts and Their Application as Annulation Reagents

Matlock, J. V.; Fritz, S. P.; Harrison, S. A.; Coe, D. M.; McGarrigle, E. M.; Aggarwal, V. K.; Synthesis of α‑Substituted Vinylsulfonium Salts and Their Application as Annulation Reagents in the Formation of Epoxide and Cyclopropane-Fused Heterocycles; J. Org. Chem.; 2014; 79; 10226−10239

link to article

To top

See, Y. Y.; Dang, T. T.; Chen, A.; Seayad, A. M.; Concise Synthesis of Vesnarinone and Its Analogues by Using Pd-Catalyzed C–N Bond-Forming Reactions; Eur. J. Org. Chem.; 2014; 7405–7412

link to article

To top
Expanding the Utility of Flow Hydrogenation – A Robust Protocol Restricting Hydrodehalogenation

Hizartzidis, L.; Cossar, P. J.; Robertson, M. J.; Simone, M. I.; Young, K. A.; McCluskeya, A.; Gordona, C. P.; Expanding the Utility of Flow Hydrogenation – A Robust Protocol Restricting Hydrodehalogenation; RSC Adv.; 2014; 4; 56743-56748

link to article

To top

Bürki, C.; Bonjoch, J.; Bradshaw, B.; Villa, G.; Renaud, P.; Total Synthesis of Aignopsanes, A Class of Sesquiterpenes: (+)-Aignopsanoic Acid A, (-)-Methyl Aignopsanoate A, and (-)-Isoaignopsanoic A; Chem. Eur. J.; 2015; 21 (1); 395 - 401

link to article

To top

Shtro, A. A.; Zarubaev, V. V.; Luzina, O. A.; Sokolov, D. N.; Kiselev, O. I.; Salakhutdinov, N. F.; Novel derivatives of usnic acid effectively inhibiting reproduction of influenza A virus; Bioorganic & Medicinal Chemistry; 2014; 22 (24); 6826–6836

link to article

To top
Total Synthesis of the Macrocyclic N‑Methyl Enamides Palmyrolide A and 2S‑Sanctolide A

Wadsworth, A. D.; Furkert, D. P.; Brimble, M. A.; Total Synthesis of the Macrocyclic N‑Methyl Enamides Palmyrolide A and 2S‑Sanctolide A; J. Org. Chem.; 2014; 79 (22); 11179–11193

link to article

To top

Ghislieri, D.; Gilmore, K.; Seeberger, P. H.; Chemical Assembly Systems: Layered Control for Divergent, Continuous, Multistep Syntheses of Active Pharmaceutical Ingredients; Angew. Chem. Int. Ed.; 2014; 53; 1 – 6

link to article

To top

Ott, D.; Kralisch, D.; Dencic, I.; Hessel, V.; Laribi, Y.; Perrichon, P. D.; Berguerand, C.; Kiwi-Minsker, L.; Loeb, P.; Life Cycle Analysis within Pharmaceutical Process Optimization and Intensification: Case Study of Active Pharmaceutical Ingredient Production; ChemSusChem; 2014; 7; 3521 – 3533

link to article

To top

Nemethne-Sovago, J.; Benke, M.; Microreactors: A new concept for chemical synthesis and technological feasibility; Materials Science and Engineering; 2014; 39; 89 - 101

link to article

To top
 A Continuous-Flow Microwave Reactor for Conducting High-Temperature and High-Pressure Chemical Reactions

Sauks, J. M.; Mallik, D.; Lawryshyn, Y.; Bender, T.; Organ, M.; A Continuous-Flow Microwave Reactor for Conducting High-Temperature and High-Pressure Chemical Reactions; Org. Process Res. Dev.; 2014; 18 (11); 1310–1314

link to article

To top

Mingozzi, M.; Manzoni, L.; Arosio, D.; Corso, A. D.; Manzotti, M.; Innamorati, F.; Pignataro, L.; Lecis, D.; Delia, D.; Seneci, P.; Gennari, C.; Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting αvβ3/αvβ5 integrins and IAP proteins; Org. Biomol. Chem.; 2014; 12; 3288-3302

link to article

To top

Budhadev, D.; Mukhopadhyay, B.; Synthesis of two trisaccharides related to the hepatoprotective phenylethanoids leonoside E and F isolated from Leonurus japonicus Houtt; Carbohydrate Research; 2014; 384; 51-55

link to article

To top

Flores, A.; Camarasa, M. J.; Pérez-Pérez, M. J.; San- Félix, A.; Balzarini, J.; Quesada, E.; Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties as novel synthetic polyphenols directed against HIV-1; Org. Biomol. Chem.; 2014; 12; 5278-5294

link to article

To top

Schröder, F.; Present and Future of Cyclopropanations in Fragrance Chemistry; Chemistry & Biodiversity; 2014; 11(11); 1734-1751

link to article

To top

Leese, M. P.; Jourdan, F. L.; Major, M. R.; Dohle, W.; Hamel, E.; Ferrandis, E.; Fiore, A.; Kasprzyk, P. G.; Potter, B. V. L.; Tetrahydroisoquinolinone-based Steroidomimetic and Chimeric Microtubule Disruptors; ChemMedChem.; 2014; 9(1); 85-108

link to article

To top
Epoxy Resin Monomers with Reduced Skin Sensitizing Potency

O'Boyle, N. M.; Niklasson, I. B.; Tehrani-Bagha, A. R.; Delaine, T.; Holmberg, K.; Luthman, K.; Karlberg, A. T.; Epoxy Resin Monomers with Reduced Skin Sensitizing Potency; Chem. Res. Toxicol.; 2014; 27(6); 1002–1010

link to article

To top
A continuous process for glyoxal valorisation using tailored Lewis-acid zeolite catalysts

Dapsens, P. Y.; Mondelli, C.; Kusema, B. T.; Verel, R., Pérez-Ramírez, J.; A continuous process for glyoxal valorisation using tailored Lewis-acid zeolite catalysts; Green Chem.; 2014; 16; 1176–1186

link to article

To top
 Evaluation of SILP-Pd catalysts for Heck reactions in amicrofluidics-based high throughput flow reactor

Urbán, B.; Srankó, D.; Sáfrán, Gy.; Ürge, L.; Darvas, F.; Bakos, J.; Skoda-Földes, R.; Evaluation of SILP-Pd catalysts for Heck reactions in amicrofluidics-based high throughput flow reactor; Journal of Molecular Catalysis A: Chemical; 2014; 395; 364-372

link to article

To top
Aziridine Ring Opening for the Synthesis of Sphingolipid Analogues: Inhibitors of Sphingolipid-Metabolizing Enzymes

Alcaide, A.; Llebaria, A.; Aziridine Ring Opening for the Synthesis of Sphingolipid Analogues: Inhibitors of Sphingolipid-Metabolizing Enzymes; J. Org. Chem.; 2014; 79(7); 2993–3029

link to article

To top
Intramolecular Aglycon Delivery Enables the Synthesis of 6-Deoxy-β-D-manno-heptosides as Fragments of Burkholderia...

Kenfack, M. T.; Blériot, Y.; Gauthier, C.; Intramolecular Aglycon Delivery Enables the Synthesis of 6-Deoxy-β-D-manno-heptosides as Fragments of Burkholderia pseudomallei and Burkholderia mallei Capsular Polysaccharide; J. Org. Chem.; 2014; 79(10); 4615–4634

To top

Kim, J.; Moon, S. H.; Kim, B. T.; Chae, C. H.; Lee, J. Y.; Kim, S. H.;A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells; PLoS One; 2014; 9(10); e110180

link to article

To top

Jensen, K. F.; Reizman, B. J.; Newman, S. G.; Tools for chemical synthesis in microsystems; Lab. Chip; 2014; 14; 3206-3212 

link to article

To top

Joyard, Y.; Bischoff, L.; Levacher, V.; Papamicaël, C.; Vera, P.; Bohn, P.; Synthesis and Stability Evaluation of New HYNIC Derivatives as Ligands for Technetium-99m;  Letters in Organic Chemistry; 2014; 11(3); 208-214

link to article

To top

Strand, M.; Carlssom, M.; Uvell, H.; Islam, K.; Edlund, K.; Cullman, I.; Altermark, B.; Mei, Y. F.; Elofsson, M.; Willassen, N. P.; Wadell, G.; Almqvist, F.; Isolation and Characterization of Anti-Adenoviral Secondary Metabolites from Marine Actinobacteria; Marine Drugs; 2014; 12(2); 799-821

link to article

To top
Discovery of acrylonitrile-based small molecules active against Haemonchus contortus

Gordon, C. P.; Hizartzidis, L.; Tarleton, M.; Sakoff, J. A.; Gilbert, J.; Campbell, B. E.; Gasser, R. B.; McCluskey, A.; Discovery of acrylonitrile-based small molecules active against Haemonchus contortus; Med. Chem. Commun.; 2014; 5; 159-164

link to article

To top
Evaluation of functional groups as acetyl-lysine mimetics for BET bromodomain inhibition

Sharp, P. P.; Garnier,  J. M.; Huang, D. C.; Burns, C. J.;  Evaluation of functional groups as acetyl-lysine mimetics for BET bromodomain inhibition; Med. Chem. Commun.; 2014; 5; 1834-1842

link to article

To top
Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling

Baer, S.; Nigro, J.; Madej, M. P.; Nisbet, R. M.; Suryadinata, R.; Coia, G.; Hong, L. P. T.; Adams, T. E.; Williams, C. C.; Nuttall, S. D.; Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling; Org. Biomol. Chem.; 2014; 12; 2675-2685

link to article

To top

Mingozzi, M.; Manzoni, L.; Arosio, D.; Corso, A. D.; Manzotti, M.; Innamorati, F.; Pignataro, L.; Lecis, D.; Delia, D.; Seneci, P.;  Gennari, C.; Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting αvβ3/αvβ5 integrins and IAP proteins; Org. Biomol. Chem.; 2014; 12; 3288-3302

link to article

To top
Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

Gauthier, C.; Chassagne, P.; Theillet, F. X.; Guerreiro, C.; Thouron, F.; Nato, F.; Delepierre, M.; Sansonetti, P. J.; Phalipon, A.; Mulard, L. A.; Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity; Org. Biomol. Chem.; 2014; 12; 4218-4232

link to article

To top
An efficient continuous flow approach to furnish furan-based biaryls

Trinh, T. N.; Hizartzidis, L.; Lin, A. J. S.; Harman, D. G.; McCluskey, A.; Gordon, C. P.; An efficient continuous flow approach to furnish furan-based biaryls; Org. Biomol. Chem.; 2014; 12; 9562-9571

link to article

To top
Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control

Voltrova, S.; Srogl, J.; Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control; Org. Chem. Front.; 2014; 1; 1067-1071

link to article

To top
Sequential Nitration/Hydrogenation Protocol for the Synthesis of Triaminophloroglucinol

Cantillo, D.; Damm, M.; Dallinger, D.; Bauser, M.; Berger, M.; Kappe, C. O.; Sequential Nitration/Hydrogenation Protocol for the Synthesis of Triaminophloroglucinol: Safe Generation and Use of an Explosive Intermediate under Continuous-Flow Conditions; Org. Process Res. Dev.; 2014; 18(11); 1360–1366

link to article

 

To top

West, C. E.; Pureveen, J.; Scarlett, A. G.; Lengger, S. K.; Wilde, M. J.; Korndorffer, F.; Tegelaar, E. W.; Rowland, S. J.; Can two-dimensional gas chromatography/mass spectrometric identification of bicyclic aromatic acids in petroleum fractions help to reveal further details of aromatic hydrocarbon biotransformation pathways?; Rapid Commun Mass Spectrom.; 2014; 28(9); 1023-1032

link to article

To top
Syntheses of 4-, 5-, 6-, and 7-substituted tryptamine derivatives and the use of a bromine atom as a protecting group

René, O.; Fauber, B. P.; Syntheses of 4-, 5-, 6-, and 7-substituted tryptamine derivatives and the use of a bromine atom as a protecting group; Tetrahedron Letters; 2014; 55(4); 830-833

link to article

To top
Characterization of Dispersion Effects on Reaction Optimization and Scale-Up for a Packed Bed Flow Hydrogenation Reactor

Eschelbach, J. W.; Wernick, D.; Bryan, M. C.; Doherty, E. M.; Characterization of Dispersion Effects on Reaction Optimization and Scale-Up for a Packed Bed Flow Hydrogenation Reactor; Aust. J. Chem. 2013, 66, 165–171

DOI: 10.1071/CH12450

Link to article

To top
Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis

McQuade, D. T.; Seeberger, P. H.; Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis; J. Org. Chem.; 2013; 78(13); 6384–6389

DOI: 10.1021/jo400583m

Link to article

To top
Synthesis of 4-Fluoromethylsydnones and their Participation in Alkyne Cycloaddition Reactions

Foster, R. S.; Adams, H.; Jakobi, H.; Harrity, J. P. A.; Synthesis of 4-Fluoromethylsydnones and their Participation in Alkyne Cycloaddition Reactions; J. Org. Chem.; 2013; 78(8); 4049-4064

DOI: 10.1021/jo400381a

Link to article

To top
Disubstituted 1-Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design

Bryan, M. C.; Hein, C. D.; Gao, H.; Xia, X.; Eastwood, H.; Bruenner, B. A.; Louie, S. W.; Doherty, E. M.;Disubstituted 1-Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design; ACS Comb. Sci.; 2013; 15 (9); 503–511

DOI: 10.1021/co400078r

Link to article

To top
De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments

Urich, R.; Wishart, G.; Kiczun, M.; Richters, A.; Tidten-Luksch, N.; Rauh, D.; Sherborne, B.; Wyatt, P. G.; Brenk, R.; De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments; ACS Chem. Biol.; 2013; 8 (5); 1044–1052

DOI: 10.1021/cb300729y

Link to article

To top
Recent Advances in Asymmetric Catalysis in Flow

Zhao, D.; Ding, K.; Recent Advances in Asymmetric Catalysis in Flow; ACS Catal.; 2013; 3(5), 928–944

DOI: 10.1021/cs300830x

Link to article

To top
Efficient continuous-flow synthesis of novel 1,2,3- triazole-substituted β-aminocyclohexanecarboxylic acid derivatives

Ötvös, S. B.; Georgiádes, Á.; Mándity, I. M.; Kiss, L.; Fülöp, F.; Efficient continuous-flow synthesis of novel 1,2,3- triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production; Beilstein J. Org. Chem.; 2013; 9; 1508–1516

DOI: 10.3762/bjoc.9.172

Link to article

To top
Synthesis and Structure−Activity Relationship (SAR) of 2‑Methyl-4-oxo-3-oxetanylcarbamic Acid Esters

Ponzano, S.; Bertozzi, F.; Mengatto, L.; Dionisi, M.; Armirotti, A.; Romeo, E.; Berteotti, A.; Fiorelli, C.; Tarozzo, G.; Reggiani, A.; Duranti, A.; Tarzia, G.; Mor, M.; Cavalli, A.; Piomelli, D.; Bandiera, T.; Synthesis and Structure–Activity Relationship (SAR) of 2-Methyl-4-oxo-3-oxetanylcarbamic Acid Esters, a Class of Potent N-Acylethanolamine Acid Amidase (NAAA) Inhibitors; J. Med. Chem., 2013;  56 (17); 6917–6934

DOI 10.1021/jm400739u

Link to article

To top
Design and Synthesis of Diazatricyclodecane Agonists of the G‑Protein-Coupled Receptor 119

Darout, E.; Robinson, R. P.; McClure, K. F.; Corbett, M.; Li, B.; Shavnya, A.; Andrews, M. P.; Jones, C. S.; Li, Q.; Minich, L. M.; Mascitti, V.; Guimaraes, C. R. W.; Munchhof, M. J.; Bahnck, K. B.; Cai, C.; Price, D. A.; Liras, S.; Bonin, P. D.; Cornelius, P.; Wang, R.; Bagdasarian, V.; Sobota, C. P.; Hornby, S.; Masterson, V. M.; Joseph, R. M.; Kalgutkar, A. S.; Chen, Y.; Design and Synthesis of Diazatricyclodecane Agonist of the G-Protein-Coupled Receptor 119; J. Med. Chem.; 2013; 56; 301-319

DOI 10.1021/jm301626p

Link to article

To top
How the mode of Candida antarctica lipase B immobilization affects the continuous-flow kinetic resolution

Boros, Z.; Falus, P.; Markus, M.; Weiser, D.; Olah, M.; Hornyanszky, G.; Nagy, J.; Poppe, L.; How the mode of Candida antarctica lipase B immobilization affects the continuous-flow kinetic resolution of racemic amines at various temperatures; Journal of Molecular Catalysis B: Enzymatic; 2013; 85– 86; 119– 125

DOI 10.1016/j.molcatb.2012.09.004

Link to article

To top
Towards a continuous flow environment for lipase-catalyzed reactions

Itabaiana, I. Jr.; Soter de Mariz e Miranda, L.; de Souza, R. O. M. A.; Towards a continuous flow environment for lipase-catalyzed reactions; Journal of Molecular Catalysis B: Enzymatic; 2013; 85– 86; 1– 9

DOI 10.1016/j.molcatb.2012.08.008

Link to article

 

To top
Development of Second-Generation Indole-Based Dynamin GTPase Inhibitors

Gordon, C. P.; Venn-Brown, B.; Robertson, M. J.; Young, K. A.; Chau, N.; Mariana, A.; Whiting, A.; Chircop, M.; Robinson, P. J.; McCluskey, A.; Development of Second-Generation Indole-Based Dynamin GTPase Inhibitors; J. Med. Chem.; 2013; 56; 46-59

DOI 10.1021/jm300844m

Link to article

To top
Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis

Desai, B.; Dixon, K.; Farrant, E.; Feng, Q.; Gibson, K. R.; van Hoorn, W. P.; Mills, J.; Morgan, T.; Parry, D. M.; Ramjee, M. K.; Selway, C. N.; Tarver, G. J.; Whitlock, G.; Wright, A. G.; Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform; J. Med. Chem.; 2013; 56(7); 3033-3047

DOI 10.1021/jm400099d

Link to article

To top
Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists

Batie, S.; Lee, J. H.; Jama, R. A:; Browder, D. O.; Montano, L. A.; Huynh, C. C.; Marcus, L. M.; Tsosie, D. G.; Mohammed, Z.; Trang, V.; Marshall, P. A.; Jurutka, P. W.; Wagner, C. E.; Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists; Bioorganic & Medicinal Chemistry; 2013; 21; 693–702

DOI: 10.1016/j.bmc.2012.11.033

Link to article

To top
Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds

Joyard, Y.; Azzouz, R.; Bischoff, L.; Papamicaël, C.; Labar, D.; Bol, A.; Bol, V.; Vera, P.; Grégoire, V.; Levacher, V.; Bohn, P.; Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds; Bioorganic & Medicinal Chemistry; 2013; 21; 3680–3688

DOI: 10.1016/j.bmc.2013.04.029

Link to article

To top
Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide

Giordanetto, F.; Wĺllberg, A.; Knerr, L.; Selmi, N.; Ullah, V.; Thorstensson, F.; Lindelöf, L.; Karlsson, S.; Nikitidis, G.; Llinas, A.; Wang, Q. D.; Lindqvist, A.; Högberg, L.; Lindhardt, E.; Ĺstrand, A.; Duker, G.; Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor; Bioorganic & Medicinal Chemistry Letters2013; 23; 119–124

DOI: 10.1016/j.bmcl.2012.10.140

Link to article

To top
Important Industrial Procedures Revisited in Flow: Very Efficient Oxidation and N-Alkylation Reactions with High Atom-Economy

Sipos, G.; Gyóllai, V.; Dormán, Gy.; Kocsis, L.; Jones, R. V.; Darvas, F.; Important industrial procedures revisited in flow: Very efficient oxidation and N-alkylation reactions with high atom-economy; Journal of Flow Chemistry; 2013; 3(2); 51-58

DOI 10.1556/JFC-D-12-00025

Link to article

To top
Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507

Scott, D. A.; Dakin, L. A.; Daly, K.; Del Valle, D. J.; Diebold, R. B.; Drew, L.; Ezhuthachan, J.; Gero, T. W.;  Ogoe, C. A.; Omer, C. A.; Redmond, S. P.; Repik, G.; Thakur, K.; Ye, Q.; Zheng, X.; Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507; Bioorganic & Medicinal Chemistry Letters; 2013; 23; 4591–4596

DOI: 10.1016/j.bmcl.2013.06.031

Link to article

To top
Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1

Manka , J. T.; Rodriguez , A. L.; Morrison, R. D.; Venable, D. F.; Cho, H. P.; Blobaum, A. L.; Daniels, J. S.; Niswender, C. M.; Conn, P. J.; Lindsley, C. W.; Emmitte, K. A.; Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1; Bioorganic & Medicinal Chemistry Letters; 2013; 23 (18); 5091–5096

DOI: 10.1016/j.bmcl.2013.07.029

Link to article

To top
A benchtop continuous flow reactor: A solution to the hazards posed by gas cylinder based hydrogenation

Dormán, Gy.; Kocsis, L.; Jones, R.; Darvas, F.; A benchtop continuous flow reactor: A solution to the hazards posed by gas cylinder based hydrogenation; Journal of Chemical Health and Safety; 2013; 20 (4); 3–8

DOI 10.1016/j.jchas.2013.01.002

Link to article

To top

Sutton, P. A.; Wilde, M. J.; Martin, S. J.; Cvacka, J.; Vrkoslav, V.; Rowland, S. J.; Studies of long chain lipids in insects by high temperature gas chromatography and high temperature gas chromatography–mass spectrometry; Journal of Chromatography A; 2013; 1297; 236– 240

DOI 10.1016/j.chroma.2013.05.006

Link to article

To top
Gram scale de novo synthesis of 2,4-diacetamido-2,4,6-trideoxy-D-galactose

Schmölzer, C.; Nowikow, C.; Kählig, H.; Schmid, W.; Gram scale de novo synthesis of 2,4-diacetamido-2,4,6-trideoxy-D-galactose; Carbohydrate Research; 2013; 367; 1–4

DOI: 10.1016/j.carres.2012.11.019

Link to article

To top
Visually Following the Hydrogenation of Curcumin to Tetrahydrocurcumin in a Natural Product Experiment

Wagner, C. E.; Marshall, P. A.; Cahill, T. M.; Mohamed, Z.; Visually Following the Hydrogenation of Curcumin to Tetrahydrocurcumin in a Natural Product Experiment That Enhances Student Understanding of NMR Spectroscopy; J. Chem. Educ.; 2013; 90(7); 930–933

DOI 10.1021/ed3002489

Link to article

To top
Ruthenium and Osmium complexes of novel carbohydrate derived salen ligands

Mandal, S.; Mandal, S.; Seth, D. K.; Mukhopadhyay, B.; Gupta, P.; Ruthenium and osmium complexes of novel carbohydrate derived salen ligands: Synthesis, characterization and in situ ligand reduction; Inorganica Chimica Acta; 2013; 398; 83–88

DOI 10.1016/j.ica.2012.12.016

Link to article

To top

Stevanovié, D.; Pejovié, A.; Damljanovié, I. S.; Vukiéevié, M. D.; Dobrikov, G.; Dimitrov, V.; Denié, M. S.; Radulovié, N. S.; Vukiéevié, R. D.; Electrochemical Phenylselenoetherification as a Key Step in the Synthesis of (±)-Curcumene Ether; Helvetica Chimica Acta; 2013; 96(6); 1103–1110

DOI: 10.1002/hlca.201200610

Link to article

To top
Nanocatalysis in continuous flow: supported iron oxide nanoparticles for the heterogeneous aerobic oxidation of benzyl alcohol

Obermayer, D.; Balu, A. M.; Romero, A. A.; Goessler, W.; Luque, R.; Kappe, C. O.; Nanocatalysis in continuous flow: supported iron oxide nanoparticles for the heterogeneous aerobic oxidation of benzyl alcohol; Green Chem.; 2013; 15; 1530–1537

DOI 10.1039/c3gc40307f

Link to article

 

To top
The role of flow in green chemistry and engineering

Newman, S. G.; Jensen, K. F.; The role of flow in green chemistry and engineering; Green Chem.; 2013; 15; 1456-1472

DOI 10.1039/c3gc40374b

Link to article

To top

Ötvös, S. B.; Mándity, I. M.; Kiss, L.; Fülöp, F.; Alkyne–Azide Cycloadditions with Copper Powder in a High-Pressure Continuous-Flow Reactor: High-Temperature Conditions versus the Role of Additives; Chem. Asian J.; 2013; 8; 800 – 808

DOI: 10.1002/asia.201201125

Link to article

To top
Single Operation Stereoselective Synthesis of Aerangis Lactones

Fink, M. J.; Schçn, M.; Rudroff, F.; Schnürch, M.; Mihovilovic, M. D.; Single Operation Stereoselective Synthesis of Aerangis Lactones: Combining Continuous Flow Hydrogenation and Biocatalysts in a Chemoenzymatic Sequence; Chem.Cat.Chem.; 2013; 5; 724 – 727

DOI: 10.1002/cctc.201200753

Link to article

To top
Rapid Microfluidic Flow Hydrogenation for Reduction or Deprotection of 18F-Labeled Compounds

Liang, S. H.; Collier, T. L.; Rotstein, B. H.; Lewis, R.; Steck, M.; Vasdev, N.; Rapid Microfluidic Flow Hydrogenation for Reduction or Deprotection of 18F-Labeled Compounds; Chem. Commun., 2013; 49(78); 8755-8757

DOI: 10.1039/c0xx00000x

Link to article

To top

Total Synthesis, Stereochemical Assignment, and Biological Activity of Chamuvarinin and Structural Analogues; Florence, G. J.; Morris, J. C.; Murray, R. G.; Vanga, R. R.; Osler, J. D.; Smith, T. K.; Chemistry - A European Journal; 2013; 19(25); 8309-8320

DOI: 10.1002/chem.201204527

Link to article

To top

Petersen, T. P.; Mirsharghi, S.; Rummel, P. C.; Thiele, S.; Rosenkilde, M. M.; Ritzén, A.; Ulven, T.; Multistep Continuous-Flow Synthesis in Medicinal Chemistry: Discovery and Preliminary Structure–Activity Relationships of CCR8 Ligands; Chemistry - A European Journal; 2013; 19(28); 9343-9350

DOI: 10.1002/chem.201204350

Link to article

To top
Site-Selective Deuterated-Alkene Synthesis with Palladium on Boron Nitride

Yabe, Y.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Site-Selective Deuterated-Alkene Synthesis with Palladium on Boron Nitride; Chemistry - A European Journal; 2013; 19; 484–488

DOI: 10.1002/chem.201203337

Link to article

To top

Sundén, H.; Ma, J. N.; Hansen, L. K.; Gustavsson, A. L.; Burstein, E. S.; Olsson, R.; Design of a Highly Selective and Potent Class of Nonplanar Estrogen Receptor β Agonists; Chem.Med.Chem; 2013; 8 (8); 1283 - 1294

DOI: 10.1002/cmdc.201300175

Link to article

To top

Godfrey, A.G.; Masquelin, T.; Hemmerle, H..; A remote-controlled adaptive medchem lab: an innovative approach to enable drug discovery in the 21st Century; Drug Discov. Today; 2013; 18 (17-18); 795 - 802

DOI: 10.1016/j.drudis.2013.03.001

Link to article

To top
3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis; Ferrins, L.; Rahmani, R.; Sykes, M. L.; Jones, A. J.; Avery, V. M.; Teston, E.; Almohaywi, B.; Yin, J.; Smith, J.;  Hyland, C.; White, K. L.; Ryan, E.; Campbell, M.; Charman, S. A.; Kaiser, M.; Baell, J. B.; European Journal of Medicinal Chemistry; 2013; 66; 450- 465

DOI: 10.1016/j.ejmech.2013.05.007

Link to article

To top
A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir

Dalla-Vechia, L.; Reichart, B.; Glasnov, T. N.; Miranda, L. S. M.; Kappe, C. O.; deSouza, R.; A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir; Org. Biomol. Chem.; 2013; 11; 6806 - 6813

DOI: 10.1039/C3OB41464G

Link to article

To top
Spirocyclic Dihydropyridines by Electrophile-Induced Dearomatizing Cyclization of N-Alkenyl Pyridinecarboxamides

Senczyszyn, J.; Brice, H.; Clayden, J.; Spirocyclic Dihydropyridines by Electrophile-Induced Dearomatizing Cyclization of N-Alkenyl Pyridinecarboxamides; Org. Lett.; 2013; 15(8); 1922–1925

DOI: 10.1021/ol400571j

Link to article

To top
Improved Continuous Flow Processing: Benzimidazole Ring Formation via Catalytic Hydrogenation of an Aromatic Nitro Compound

Chen, J.; Roemmele, R. C.; Przyuski, K.; Bakale, R. P.; Improved Continuous Flow Processing: Benzimidazole Ring Formation via Catalytic Hydrogenation of an Aromatic Nitro Compound; Org. Process Res. Dev.2014, 18 (11), pp 1427–1433

DOI: 10.1021/op400179f

Link to article

To top
Concise synthesis of a tetra- and a trisaccharide related to the repeating unit of the O-antigen from Providencia

Verma, P. R.; Mukhopadhyay, B.; Concise synthesis of a tetra- and a trisaccharide related to the repeating unit of the O-antigen from Providencia rustigianii O34 in the form of their p-methoxyhenyl glycosides; RSC Adv; 2013; 3; 201–207

DOI: 10.1039/c2ra22407k

Link to article

To top
Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-Activity Relationship (SAR)

Pizzirani, D.; Pagliuca, C.; Realini, N.; Branduardi, D.; Bottegoni, G.; Mor, M.; Bertozzi, F.; Scarpelli, R.; Piomelli, D.; Bandiera, T.; Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-Activity Relationship (SAR); J. Med. Chem.; 2013; 56 (9); 3518-3530

DOI: 10.1021/jm301879g

Link to article

To top

Palko, M.; Hanninen, M. M.; Sillanpaa, R.; Fulop, F.; Syntheses of Four Enantiomers of 2,3-Diendo- and 3-Endo-aminobicyclo[2.2.2]oct-5-ene-2-exo-carboxylic Acid and Their Saturated Analogues; Molecules; 2013; 18; 15080-15093

DOI: 10.3390/molecules181215080

Link to article

To top
α-1,4-Galacrosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins

Simerska, P.; Christie, M. P.; Goodwin, D.; Jen, F. E.-C.; Jennings, M. P.; Toth, I.; α-1,4-Galacrosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins; Journal of Molecular Catalysis B: Enzymatic; 2013; 97; 196-202

DOI

To top
Enzymatic reactions for the preparation of homocalycotomine enantiomers

Schönstein, L.; Forró, E.; Fulop, F.; Enzymatic reactions for the preparation of homocalycotomine enantiomers; Tetrahedron: Asymmetry; 2013; 24; 1059-1062

DOI: 10.1016/j.tetasy.2013.07.025

Link to article

To top
Flow synthesis of annulated 5-aryl-substituted pyridines

Martin, R. E.; Lenz, M.; Akzieu, T.; Aebi, J. D.; Forzy, L.; Flow synthesis of annulated 5-aryl-substituted pyridines by tandem intramolecular inverse-electron-demand hetero-/retro-Diels-Alder reaction; Tetrahedron Letters; 2013; 54; 6703-6707

DOI: 10.1016/j.tetlet.2013.09.069

Link to article

To top

Plutschack, M. B.; McQuade, D. T.; Valenti, G.; Seeberger, P. H.; Flow Synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe; Beilstein J. Org. Chem.; 2013; 9; 2022-2027

DOI: 10.3762/bjoc.9.238

Link to article

To top
 Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a

Chassagne, P.; Raibaut, L.; Guerreiro, C.; Mulard, L. A.; Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxidation; Tetrahedron; 2013; 10337-10350

DOI: 10.1016/j.tet.2013.10.011

Link to article

To top

Redwan, I. N.; Bliman, D.; Tokugawa, M.; Lawson, C.; Grøtli, M.; Synthesis and photophysical characterization of 1- and 4-(purinyl)triazoles; Tetrahedron; 2013; 69 (42); 8857–8864

DOI: 10.1016/j.tet.2013.08.023

Link to article

To top
Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a]pyridine

Bazin, M. An.; Marhadour, S.; Tonnerre, A.; Marchand, P.; Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a]pyridine: expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines; Tetrahedron Letters; 2013; 54 (39); 5378–5382

DOI: 10.1016/j.tetlet.2013.07.113

Link to article

To top
Synthesis of γ-valerolactone using a continuous-flow reactor

Tukacs, J. M.; Jones, R. V.; Darvas, F.; Lezsák, G.; Dibó, G.; Mika, L. T.; Synthesis of γ-valerolactone using a continuous-flow reactor; RSC Adv.; 2013; 3, 16283-16287

DOI: 10.1039/C3RA43032D

Link to article

To top
otal syntheses of the dipyrrolobenzoquinone (+) -terreusinone enabled by an evaluation of 4-methylpent-1-yn-3-ols

Wang, C.; Sperry, J.;  Total syntheses of the dipyrrolobenzoquinone (+) -terreusinone enabled by an evaluation of 4-methylpent-1-yn-3-ols in the Larock indole synthesis; Tetrahedron Letters; 2013; 69; 4563–4577

DOI: 10.1016/j.tet.2013.04.025

Link to article

To top
Continuous-flow enzymatic resolution strategy for the acylation of amino alcohols with a remote stereogenic centre

Schönstein, L.; Forró, E.; Fülöp, F.; Continuous-flow enzymatic resolution strategy for the acylation of amino alcohols with a remote stereogenic centre: synthesis of calycotomine enantiomers; Tetrahedron: Asymmetry; 2013; 24; 202–206

DOI: 10.1016/j.tetasy.2013.01.006

Link to article

To top
Chemical and bacterial reduction of azo-probes:monitoring a conformational change using fluorescence spectroscopy

Rattray, N. J. W.; Zalloum, W. A.; Mansell, D.; Latimer, J.; Jaffar, M.; Bichenkova, E. V.; Freeman, S.; Chemical and bacterial reduction of azo-probes:monitoring a conformational change using fluorescence spectroscopy; Tetrahedron; 2013; 69; 2758–2766

DOI: 10.1016/j.tet.2013.01.086

Link to article

 

To top

Rudzinski, D. M.; Leadbeater, N. E.; Microwave heating and conventionally-heated continuous-flow processing as tools for performing cleaner palladium-catalyzed decarboxylative couplings using oxygen as the oxidant – a proof of principle study; Green Processing and Synthesis; 2013; 2 (4); 323–328

DOI: 10.1515/gps-2013-0043

Link to article

 

To top
Disubstituted 1-Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design and High-Throughput Batch

Bryan, M.C.; Hein, C.D.; Gao, H.; Xia, X.; Eastwood, H.; Bruenner, B.A.; Louie, S.W.; Doherty, E.M; Disubstituted 1-Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design and High-Throughput Batch and Flow Technologies; ACS Comb. Sci.; 2013; 15 (9); 503–511

link to article

To top
Application of Factorial Design of Experiments for the Continuous Hydrogenation of Enriched Castor Oil Methyl Esters

Neeharika, T.S.V.R.; Rani, K.N.P.; Rao, K.V.S.A.; Kumar, T.P.; Prasad, R.B.N.; Application of Factorial Design of Experiments for the Continuous Hydrogenation of Enriched Castor Oil Methyl Esters; Bulletin of Chemical Reaction Engineering & Catalysis; 2013; 8 (2); 154-159

link to article

To top
Continuous flow nanocatalysis: reaction pathways in the conversion of levulinic acid to valuable chemicals

Bermudez, J.M.; Menéndez, J.A.; Romero, A.A.; Serrano, E.; Garcia-Martinez, J.; Lugue, R.; Continuous flow nanocatalysis: reaction pathways in the conversion of levulinic acid to valuable chemicals; Green Chem.; 2013; 15(10); 2786-2792

link to article

To top
Enantioselective access to benzannulated spiroketals using a chiral sulfoxide auxiliary

Aitken, H.R.M.; Furkert, D.P.; Hubert, J.G.; Wood, J.M.; Brimble, M.A.; Enantioselective access to benzannulated spiroketals using a chiral sulfoxide auxiliary; Org. Biomol. Chem.; 2013; 11; 5147-5155

link to article

To top
Concise synthesis of the trisaccharide repeating unit of the O-polysaccharide from Aeromonas hydrophila A19 (O:14)

Pal, K.B.; Mukhopadhyay, B.; Concise synthesis of the trisaccharide repeating unit of the O-polysaccharide from Aeromonas hydrophila A19 (O:14); Carbohydrate Research; 2013; 379; 26-29

link to article

To top
Flow Chemistry Syntheses of Natural Products

Pastre, J.C.; Browne, D.L.; Ley, S.V.; Flow Chemistry Syntheses of Natural Products; Chem. Soc. Rev.; 2013; 42; 8849-8869

link to article

To top

Deiters, E.; Eliseeva, S.V.; Bünzil, J.C.G.; Self-assembly of a helical zinc-europium complex: speciation in aqueous solution and luminescence; Front. Chem.; 2013; 1(15); 1-14

link to article

To top
Highly efficient iron(0) nanoparticle-catalyzed hydrogenation in water in flow

Hudson, R.; Hamasaka, G.; Osako, T.; Yamada, Y.M.A.; Li, C.J.; Uozumi, Y.; Moores, A.; Highly efficient iron(0) nanoparticle-catalyzed hydrogenation in water in flow; Green Chem.; 2013; 15; 2141-2148

link to article

To top

Baxendale, I.R.; Brocken, L.; Mallia, C.J.; Flow chemistry approaches directed at improving chemical synthesis; Green Process. Synth.; 2013; 2(3) ; 211-230

link to article

To top

Baxendale, I.R.; The integration of flow reactors into synthetic organic chemistry; J. Chem. Technol. Biotechnol.; 2013; 88; 519–552

link to article

To top

Sutton, P.A.; Wilde, M.J.; Martin, S.J.; Cvačka, J.; Vrkoslav, V.; Rowland, S.J.; Studies of long chain lipids in insects by high temperature gas chromatography and high temperature gas chromatography–mass spectrometry; Journal of Chromatography A; 2013; 1297; 236-240

link to article

To top
VUT-MK142 : a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes

Koley, M.; Mike, A.K.; Heher, P.; Koenig, X.; Schön, M.; Schnürch, M.; Hilber, K.; Weitzer, G.; Mihovilovic, M.D.; VUT-MK142 : a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes; Med. Chem. Commun.; 2013; 4; 1189-1195

link to article

To top
Versatile low-loaded mechanochemically synthesized supported iron oxide nanoparticles for continuous flow alkylations

Balu, A. M.; Pineda, A.; Obermayer, D.; Romero, A. A., Kappe, C. O.; Luque, R.; Versatile low-loaded mechanochemically synthesized supported iron oxide nanoparticles for continuous flow alkylations; RSC Adv.; 2013; 3; 16292-16295

link to article

To top
Total syntheses of the dipyrrolobenzoquinone (+)-terreusinone enabled by an evaluation of 4-methylpent-1-yn-3-ols

Wang, C.; Sperry, J.; Total syntheses of the dipyrrolobenzoquinone (+)-terreusinone enabled by an evaluation of 4-methylpent-1-yn-3-ols in the Larock indole synthesis; Tetrahedron; 2013; 69(23); 4563-4577

link to article

To top
Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors

Lawrence, H. R.; Martin, M.P.; Luo, Y.; Pireddu, R.; Yang, H.; Gevariya, H.; Ozcan, S.; Zhu, J.Y.; Kendig, R.; Rodriguez, M.; Elias, R.; Cheng, J.Q.; Sebti, S.M.; Schonbrunn, E.;Lawrence, N.J.; Development of o-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors; J. Med. Chem., 2012; 55 (17); 7392–7416

DOI: 10.1021/jm300334d

Link to article

To top
Synthesis of Phenols via Fluoride-free Oxidation of Arylsilanes and Arylmethoxysilanes

Rayment, E. J.; Summerhill, N.; Anderson, E. A.; Synthesis of Phenols via Fluoride-free Oxidation of Arylsilanes and Arylmethoxysilanes;  J. Org. Chem.; 2012; 77 (16); 7052–7060

DOI: 10.1021/jo301363h

Link to article

To top
First Enantioselective Total Synthesis of (+)-(R)-Pinnatolide Using an Asymmetric Domino Allylation Reaction

Tietze, L. F.; Wolfram, T.; Holstein, J. J.; Dittrich, B.; First Enantioselective Total Synthesis of (+)-(R)-Pinnatolide Using an Asymmetric Domino Allylation Reaction; Org. Lett.; 2012; 14 (16); 4035–4037 

DOI: 10.1021/ol301932d

Link to article

To top

Furmick, J. K.; Kaneko,I.; Walsh, A. N.; Yang,J.; Bhogal, J. S.; Gray, G. M.; Baso, J. C.; Browder, D. O., Prentice, J. L. S.; Montano, L A.; Huynh, C. C. Marcus, L. M.; Tsosie, D. G.; Kwon, J. S.; Quezada, A.; Reyes, N. M.; Lemming, B.; Saini, P.; van der Vaart, A.; Groy, T. L.;  Marshall, P. A.; Jurutka, P. W.; Wagner, C. E.; Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor-Selective Agonists: Novel Halogenated Analogues of 4-[1-(3,5,5,8,8-Pentamethyl- 5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene); ChemMedChem; 2012; 7; 1551–1566

DOI: 10.1002/cmdc.201200319

Link to article

 
To top
A Method to Identify Best Available Technologies (BAT) for Hydrogenation Reactors in the Pharmaceutical Industry

Doan, T.; Stavárek, K.; Bellefon, C.; A Method to Identify Best Available Technologies (BAT) for Hydrogenation Reactors in the Pharmaceutical Industry; J. Flow Chem.; 2012; 2(3); 77–82

link to article

To top
Synthesis and arylation of unprotected sulfonimidamides

Maldonado; M. F.; Sehgelmeble, F.; Bjarnemark, F.; Svensson, M.; Ahman, F.;Arvidsson, P. I.; Synthesis and arylation of unprotected sulfonimidamides; Tetrahedron; 2012; 68; 7456-7462

DOI: 10.1016/j.tet.2012.06.072

Link to article

To top
Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state

Baltus, C. B.; Press, N. J.; Antonijevic, M. D.; Tizzard, G. J.; Coles, S. J.; Spencer, J.; Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state; Tetrahedron; 2012; 68 (45); 9272–9277

DOI: 10.1016/j.tet.2012.08.062

Link to article

To top
Efficient and scalable synthesis of thiazole fused benzazepine as a D2 partial agonist

Xiong, H.; Wu, Y.; Lehr, S. G.; Blackwell, W.; Steelman, G.; Hulsizer, J.; Urbanek, R. A.; Efficient and scalable synthesis of thiazole fused benzazepine as a D2 partial agonist; Tetrahedron Letters; 2012; 53 (44); 5833–5836

DOI: 10.1016/j.tetlet.2012.08.035

Link to article

To top
De novo design, synthesis and pharmacological evaluation of new azaindole derivatives as dual inhibitors of Abl and Src kinases

Chevé, G.; Bories, C.; Fauvel, B.; Picot, F.; Tible, A.; Daydé-Cazals, B.; Loget, O.; Yasri, A.; De novo design, synthesis and pharmacological evaluation of new azaindole derivatives as dual inhibitors of Abl and Src kinases; Med. Chem. Commun; 2012; 3; 788-800

DOI: 10.1039/c2md20104f

Link to article

To top

Liu, J.; Fitzgerald, A. E.; Mani, N. S.; Reductive Amination by Continuous-Flow Hydrogenation: Direct and Scalable Synthesis of a Benzylpiperazine; Synthesis; 2012; 44 (15); 2469-2473

DOI: 10.1055/s-0032-1316550

Link to article

To top
Process Development of a Potent Glucosylceramide Synthase Inhibitor

Cooper, C. G. F.; Lee, E. R.; Silva, R. A.; Bourque, A. J.; Clark, S.; Katti, S.; Nivorozkhin, V.; Process Development of a Potent Glucosylceramide Synthase Inhibitor; Org. Process Res. Dev.; 2012; 16 (5); 1090–1097

DOI: 10.1021/op2001222

Link to article

To top

Malet-Sanz, L.; Susanne, F.; Continuous Flow Synthesis. A Pharma Perspective; J. Med. Chem.; 2012; 55 (9); 4062–4098

DOI: 10.1021/jm2006029

Link to article

To top

Guerin, C.; Bellosta, V.; Guillamot, G.; Cossy, J.; Synthesis of Amines from Alcohols in a Nonepimerizing One-Pot Sequence – Synthesis of Bioactive Compounds: Cinacalcet and Dexoxadrol; Eur. J. Org. Chem.; 2012; 15; 2990–3000

Doi: 10.1002/ejoc.201200171

link to article

To top
Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states

Dayde, B.; Benzaria, S.; Pierra, C.; Gosselin, G.; Surleraux, D.; Volle, J.; Pirat, J.; Virieux, D.; Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states; Org. Biomol. Chem.; 2012, 10, 3448-3454

DOI: 10.1039/c2ob25131k

link to article

To top
Using Continuous Processes to Increase Production

Anderson, N. G.; Using Continuous Processes to Increase Production; Org. Proc. Res. Dev.; 2012; 16(5); 852–869

DOI: 10.1021/op200347k

Link to article

To top
Diastereoselective 1,3-Dipolar Cycloaddition of Pyrylium Ylides with Chiral Enamides

Tchabanenko, K.; Sloan, C.; Bunetel, Y.; Mullen, P.; Diastereoselective 1,3-Dipolar Cycloaddition of Pyrylium Ylides with Chiral Enamides; Organic and Bioorganic Chemistry; 2012; 10; 4215-4219

DOI: 10.1039/c0xx00000x

Link to article

To top

Mirzayans, P. M.; Pouwer, R. H.; Williams, C. M.; Bernhardt, P. V.; Stereocontrolled Synthesis of the cis-Hydroxydecalin System: Towards Biologically Active 19-nor-Clerodanes; Eur. J. Org. Chem.; 2012; 1633-1638

DOI: 10.1002/ejoc.201101807

Link to article

To top

Battilocchio, C.; Baumann, M.; Baxendale, I. R.; Biava, M.; Kitching, M. O.; Ley, S. V.; Martin, R. E.; Ohnmacht, S. A.; Tappin, N. D. C.; Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands; Synthesis; 2012; 44; 635-647

DOI: 10.1055/s-0031-1289676

Link to article

To top
Synthesis and biological characterization of sirtuin inhibitors based on the tenovins

McCarthy, A. R.; Pirrie, L.; Hollick, J. J.; Ronseaux, S.; Campbell, J.; Higgins, M.; Staples, O. D.; Tran, F.; Slawin, A. M. Z.; Lain, S.; Westwood, N. J.; Synthesis and biological characterization of sirtuin inhibitors based on the tenovins; Bioorg. Med. Chem.; 2012; 20; 1779-1793

DOI: 10.1016/j.bmc.2012.01.001

Link to article

To top
Reagent-controlled stereoselective synthesis of (±)-gallo- and (±)-epigallo-catechin gallates

Tanaka, H.; Chino, A.; Takahashi, T.; Reagent-controlled stereoselective synthesis of (±)-gallo- and (±)-epigallo-catechin gallates; Tetrahedron Letters; 2012; 53; 2493-2495

DOI: 10.1016/j.tetlet.2012.02.065

Link to article

To top
Fatty acids residue from palm oil refining process as feedstock for lipase catalyzed monoacylglicerol production under batch

Junior, I. I.; Flores, M. C.; Sutili, F. K.; Leite, S. G. F.; de M. e Miranda, L.; Leal, I. C. R.; de Souza, R. O. M. A.; Fatty acids residue from palm oil refining process as feedstock for lipase catalyzed monoacylglicerol production under batch and continuous flow conditions; Journal of Molecular Catalysis B: Enzymatic; 2012; 77; 53-58

DOI: 10.1016/j.molcatb.2012.01.008

Link to article

To top
Asymmetric hydrogenation of C-C double bonds using Rh-complex under homogeneous, heterogeneous and continuous mode conditions

Balogh Sz.; Farkas, G.; Madarász, J.; Szöllősy, Á.; Kovács, J.; Darvas, F.; Ürge L.; Bakos, J.; Asymmetric hydrogenation of C-C double bonds using Rh-complex under homogeneous, heterogeneous and continuous mode conditions; Green Chem.; 2012; 14; 1146-1151

DOI: 10.1039/c2gc16447g

Link to article

To top
Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library

Spencer, J.; Patel, H.; Amin, J.; Callear, S. K.; Coles, S. J.; Deadman, J. J.;Furman, C.; Mansouri, R.; Chavatte, P.; Millet, R.; Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library; Tetrahedron Letters; 2012; 53; 1656–1659

DOI: 10.1016/j.tetlet.2012.01.081

Link to article

To top
Highly Efficient 1,4-Addition of Aldehydes to Nitroolefins

Ötvös, S. B.; Mándity, I. M.; Fülöp, F.; Highly Efficient 1,4-Addition of Aldehydes to Nitroolefins: Organocatalysis in Continuous Flow by Solid-Supported Peptidic Catalysts; ChemSusChem; 2012; 5; 266 – 269

DOI: 10.1002/cssc.201100332

Link to article

To top
Parallel synthesis of 1,2,4-triazole derivatives using microwave and continuous-flow techniques

Szommer T.; Lukács A.; Kovács J.; Szabó M. J.;Hoffmann M. G.; Schmitt M. H.; Gerencsér J.; Parallel synthesis of 1,2,4-triazole derivatives using microwave and continuous-flow techniques; Mol Divers.; 2012; 16(1); 81-90

DOI: 10.1007/s11030-012-9357-2

Link to article

To top
Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow

Lengyel, L.; Nagy, T. Zs.; Sipos, G.; Jones, R.; Gorman, Gy.; Ürge, L.; Darvas, F.; Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives; Tetrahedron Letters; 2012; 53; 738-743

DOI: 10.1016/j.tetlet.2011.11.125

Link to article

To top
Synthesis of Staphylococcus aureus type 5 capsular polysaccharide repeating unit

Danieli, E.; Proietti, D.; Brogioni, G.; Romano, M. R.;  Synthesis of Staphylococcus aureus type 5 capsular polysaccharide repeating unit using novel L-FucNAc and D-FucNAc synthons and immunochemical evaluation; Bioorganic & Medicinal Chemistry; 2012; 20; 6403–6415

DOI: 10.1016/j.bmc.2012.08.048

Link to article

To top
Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

Manzoni, L.; Belvisi, L.; Bianchi, A.; Conti, A.; Drago, C.; de Matteo, M.; Ferrante, L.; Mastrangelo, E.; Perego, P.; Potenza, D.; Scolastico, C.; Servida, F.; Timpano, G.; Vasile, F., Rizzo, V.; Seneci, P.; Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis; Bioorganic & Medicinal Chemistry; 2012; 20; 6687–6708

DOI: 10.1016/j.bmc.2012.09.020

Link to article

To top
Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase

Giordanetto, F.; Wĺllberg, A.; Cassel, J.; Ghosal, S.; Kossenjans, M.; Yuan, Z. Q.; Wang, X.; Liang, L.; Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation; Bioorganic & Medicinal Chemistry Letters; 2012; 22; 6665–6670

DOI: 10.1016/j.bmcl.2012.08.101

Link to article

To top
Identification and Characterization of Carprofen as a Multitarget Fatty Acid Amide Hydrolase/Cyclooxygenase Inhibitor

Favia, A. D.; Habrant, D.; Scarpelli, R.; Migliore, M.; Albani, C.; Bertozzi, S. M.; Dionisi, M.; Tarozzo, G.; Piomelli, D.; Cavalli, A.; De Vivo, M.; Identification and Characterization of Carprofen as a Multitarget Fatty Acid Amide Hydrolase/Cyclooxygenase Inhibitor; J. Med. Chem.; 2012; 55, 8807−8826

DOI 10.1021/jm3011146

Link to article

To top
Discovery of selective biaryl ethers as PDE10A inhibitors

Rzasa, R. M.; Hu, E.; Rumfelt, S.; Chen, N.; Andrews, K. L.; Chmait, S.; Falsey, J. R.; Zhong, W.; Jones, A. D.; Porter, A.; Louie, S. W.; Zhao, X.; Treanor, J. J. S.; Allen, J. R.; Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux; Bioorganic & Medicinal Chemistry Letters; 2012, 22; 7371–7375

DOI: 10.1016/j.bmcl.2012.10.078

Link to article

To top
Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2

Andrés, J. I.; Alcázar, J.; Cid, J. M.; De Angelis, M., Iturrino, L.; Langlois, X.; Lavreysen, H.; Trabanco, A. A.; Celen, S.; Bormans, G.; Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging, J. Med. Chem.; 2012; 55; 8685−8699

DOI 10.1021/jm300912k

Link to article

 

To top
Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design

Efremov, I.V.; Vajdos, F. F.; Borzilleri, K. A.; Capetta, S.; Chen, H.; Dorff, P. H.; Dutra, J. K.; Goldstein, S. W.; Mansour, M.; McColl, A.; Noell, S.; Oborski, C. E.; O’Connell, T. N.; O’Sullivan, T. J.; Pandit, J.; Wang, H.; Wei, B.; Withka, J. M.; Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design; Journal of Medicinal Chemistry; 2012; 55(21); 9069-88

DOI 10.1021/jm201715d

Link to article

To top
Discovery of 7- Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3- dihydro- 1H- indol-5-yl)- 7H- pyrrolo[2,3-d]...

Axten, J. M.; Medina, J. R.; Feng, Y.; Shu, A.; Romeril, S. P.; Grant, S. W.; Li, W. H. H.; Heerding, D. A.; Minthorn, E.; Mencken, T.; Atkins, C.; Liu, Q.; Rabindran, S.; Kumar, R.; Hong, X.; Goetz, A.; Stanley, T.; Taylor, J. D.; Sigethy, S. D.; Tomberlin, G. H.; Hassell, A. M.; Kahler, K. M.; Shewchuk, L. M.; Gampe, R. T.; Discovery of 7- Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3- dihydro- 1H- indol-5-yl)- 7H- pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK); Journal of Medicinal Chemistry; 2012; 55(16); 7193–7207

DOI 10.1021/jm300713s

Link to article

 

To top
Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors

Zak, M.; Mendonca, R.; Balazs, M.; Barrett, K.; Bergeron, P.; Blair, W. S.; Chang, C.; Deshmukh, G.; DeVoss, J.; Dragovich, P. S.; Eigenbrot, C.; Ghilardi, N.; Gibbons, P.; Gradl, S.; Hamman, C.; Hanan, E.; Harstad, E.; Hewitt, P. R.; Hurley, C. A.; Jin, T.; Johnson, A.; Johnson, T.; Kenny, J. R.; Koehler, M. F. T.; Kohli, P. B.; Kulagowski, J.; Labadie, S.; Liao, J.; Liimatta, M.; Lin, Z.; Lupardus, P. J.; Maxey, R. J.; Murray, J. M.; Pulk, R.; Rodriguez, M.; Savage, S.; Shia, S.; Steffek, M.; Ubhayakar, S.; Ultsch, M.; Van-Abbema, A.; Ward, S.; Xiao, L.; Xiao, Y.; Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2; Journal of Medicinal Chemistry; 2012; 55(13); 6176-93

DOI: 10.1021/jm300628c

Link to article

To top
Synthesis and Biological Evaluation of an Orally Active Glycosylated Endomorphin-1

Varamini, P.; Mansfeld, F. M.; Blanchfield, J. T.; Wyse, B. D.; Smith, M. T.; Toth, I.; Synthesis and Biological Evaluation of an Orally Active Glycosylated Endomorphin-1; Journal of Medicinal Chemistry; 2012; 55(12); 5859–5867

DOI 10.1021/jm300418d

Link to article

To top
Structure-Based Design of Potent and Ligand-Efficient Inhibitors of CTX-M Class A β-Lactamase

Nichols, D. A.; Jaishankar, P.; Larson, W.; Smith, E.; Liu, G.; Beyrouthy, R.; Bonnet, R.; Renslo, A. R.; Chen, Y.; Structure-Based Design of Potent and Ligand-Efficient Inhibitors of CTX-M Class A β-Lactamase; Journal of Medicinal Chemistry; 2012; 55(5); 2163-72

DOI 10.1021/jm2014138

Link to article

To top
Discovery and Synthesis of Hydronaphthoquinones as Novel Proteasome Inhibitors

Ge, Y.; Kazi, A.; Marsilio, F.; Luo, Y.; Jain. S.; Brooks, W.; Daniel, K. G.; Guida, W. C.; Sebti, S. M.; Lawrence, H. R.; Discovery and Synthesis of Hydronaphthoquinones as Novel Proteasome Inhibitors; Journal of Medicinal Chemistry; 2012; 55(5); 1978-1998

DOI 10.1021/jm201118h

Link to article

 

To top
An alternative route for fondaparinux sodium synthesis

Manikowski, A.; Kozioł, A.; Czajkowska-Wojciechowska, E.; An alternative route for fondaparinux sodium synthesis via selective hydrogenations and sulfation of appropriate pentasaccharides; Carbohydrate Research; 2012; 361; 155–161

DOI: 10.1016/j.carres.2012.08.020

Link to article

To top
Asymmetric aldol reaction in a continuous-flow reactor catalyzed by a highly reusable heterogeneous peptide

Ötvös, S. B.; Mándity, I. M.; Fülöp, F.; Asymmetric aldol reaction in a continuous-flow reactor catalyzed by a highly reusable heterogeneous peptide; Journal of Catalysis; 2012; 295; 179–185

DOI 10.1016/j.jcat.2012.08.006

Link to article

To top
A practical and benign synthesis of amines through Pd@mpg-C3N4 catalyzed reduction of nitriles

Li, Y.; Gong, Y.; Xu, X.; Zhang, P.; Li, H.; Wang, Y.; A practical and benign synthesis of amines through Pd@mpg-C3N4 catalyzed reduction of nitriles; Catalysis Communications; 2012; 28; 9–12

DOI: 10.1016/j.catcom.2012.08.005

Link to article

To top

Cochi, A. ; Pardo, D. G.; Cossy, J.; Access to Optically Active 3-Aminopiperidines by Ring Expansion of Prolinols: Thermodynamic versus Kinetic Control; European Journal of Organic Chemistry; 2012; (10); 2023–2040

DOI 10.1002/ejoc.201101829

Link to article

To top
Heterogeneous Enantioselective Hydrogenation in a Continuousflow Fixed-bed Reactor System

Szőllősi, Gy.; Makra, Zs.; Fekete, M.; Fülöp, F.; Martók, M.; Heterogeneous Enantioselective Hydrogenation in a Continuousflow Fixed-bed Reactor System: Hydrogenation of Activated Ketones and Their Binary Mixtures on Pt–Alumina–Cinchona Alkaloid Catalysts; Catalysis Letters; 2012; 142; 889-894

DOI: 10.1007/s10562-012-0846-9

Link

To top

de Beer, R.J.A.C.; Zarzycka, B.; Mariman, M.; Amatdjais- Groenen, H. I. V.; Mulders, M. J.; Quaedflieg, P. J. L. M.; van Delft, F. L.; Nabuurs, S. B.; Rutjes, F. P. J. T.; Papain-Specific Activating Esters in Aqueous Dipeptide Synthesis; ChemBioChem; 2012; 13; 1319–1326

DOI: 10.1002/cbic.201200017

Link to article

To top

Ansiaux, C.; N’Go, I.; Vincent, S. P.; Reversible and Efficient Inhibition of UDP-Galactopyranose Mutase by Electrophilic, Constrained and Unsaturated UDP-Galactitol Analogues; Chem. Eur. J.; 2012; 18; 14860-14866

DOI: 10.1002/chem.201202302

Link to article

To top
Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents

Marhadour, S.; Marchand, P.; Pagniez, F.; Bazin, M.A.; Picot, C.; Lozach, O.; Ruchaud, S.; Antoine, M.; Meijer, L.; Rachidi, N.; Le Pape, P.; Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents; European Journal of Medicinal Chemistry2012; 58; 543-556

DOI: 10.1016/j.ejmech.2012.10.048

Link to article

To top
Lipase-Catalyzed Monostearin Synthesis Under Continuous Flow Conditions

Junior, I.I.; Flores, C.M.; Sutili, F.K.; Leite, S.G.F.; Miranda, L.S. de M.; Leal, I.C.R.; de Souza, R.O.M.A.; Lipase-Catalyzed Monostearin Synthesis Under Continuous Flow Conditions;  Org. Process Res. Dev.; 2012; 16 (5); 1098–1101

DOI: 10.1021/op200132y

Link to article
 

To top
High-speed microwave assisted synthesis of SEA0400 — a selective inhibitor of the Na+/Ca2+ exchanger

Cruz, G.G.; Groschner, K.;  Kappe, C. O.; Glasnov; T. N.; High-speed microwave assisted synthesis of SEA0400 — a selective inhibitor of the Na+/Ca2+ exchanger; Tetrahedron Letters; 2012; 53; 3731–3734

DOI: 10.1016/j.tetlet.2012.04.120

Link to article

 

To top
 Metal-catalyzed amidation

Roy, S.; Roy, S.; Gribble, G. W.;  Metal-catalyzed amidation; Tetrahedron; 2012; 68; 9867 – 9923

DOI: 10.1016/j.tet.2012.08.065

Link to article

 

 

To top
Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors

Tite, T.; Tomas, L.; Docsa, T.; Gergely, P.; Kovensky, J.; Gueyrard, D.; Wadouachi, A.; Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors; Tetrahedron Letters; 2012; 53; 959–961

DOI: 10.1016/j.tetlet.2011.12.049

Link to article

To top
Scalable synthesis of an integrin-binding peptide mimetic for biomedical applications

Riches, A. G.;  Cablewski, T.; Glattauer, V.;  Thissen, H.;  Meagher, L.; Scalable synthesis of an integrin-binding peptide mimetic for biomedical applications; Tetrahedron; 2012; 68; 9448 – 9455

DOI: 10.1016/j.tet.2012.09.002

Link to article

To top

Richardson; P.; Ask the Experts: The challenges and benefits of flow chemistry to optimize drug development; Future Medicinal Chemistry; 2012; 4(14); 1779-1789

DOI: 10.4155/fmc.12.106

Link to article

To top

Wegner, J.; Ceylan, S.; Kirschning, A.; Flow Chemistry – A Key Enabling Technology for (Multistep) Organic Synthesis; Adv. Synth. Catal.; 2012; 354; 17–57

link to article

To top

Serrano-Ruiz, J.C.; Luque, R.; Campelo, J.M.; Romero, A.A.; Continuous-Flow Processes in Heterogeneously Catalyzed Transformations of Biomass Derivatives into Fuels and Chemicals; Challenges; 2012; 3; 114-132

link to article

To top
Microwave-assisted synthesis of medium-sized heterocycles

Sharma, A.; Appukkuttan, P.; Van der Eycken, E.; Microwave-assisted synthesis of medium-sized heterocycles; Chem. Commun.; 2012; 48; 1623-1637

link to article

To top

Chinnusamy, T.; Yudha S.S.; Hager, M.; Kreitmeier, P.; Reisen, O.; Application of Metal-Based Reagents and Catalysts in Microstructured Flow Devices; ChemSusChem; 2012; 5(2); 247-255

link to article

To top
Synthesis and anticancer activity of a series of norcantharidin analogues

Tarleton, M.; Gilbert, J.; Sakoff, J.A.; McCluskey, A.; Synthesis and anticancer activity of a series of norcantharidin analogues; European Journal of Medicinal Chemistry; 2012; 54; 573-581

link to article

To top
Continuous flow reactors: a perspective

Wiles, C.; Watts, P.; Continuous flow reactors: a perspective; Green Chem.; 2012; 14; 38-54

link to article

To top
Catalysis in flow: Au-catalysed alkylation of amines by alcohols

Zotova, N.; Robert, F.J.; Kelsall, G.H.; Jessiman, A.S.; Hellgardt, K.; Hii, K.K.; Catalysis in flow: Au-catalysed alkylation of amines by alcohols; Green Chem.; 2012; 14; 226-232

link to article

To top
Versatile dual hydrogenation–oxidation nanocatalysts for the aqueous transformation of biomass-derived platform molecules

García-Suárez, E.J.; Balu A.M.; Tristany, M.; García, A.B.; Philippot, K.; Lugue, R.; Versatile dual hydrogenation–oxidation nanocatalysts for the aqueous transformation of biomass-derived platform molecules; Green Chem.; 2012; 14; 1434-1439

link to article

To top

Glasnov, T.N.; Holbrey, J.D.; Kappe, C.O.; Seddon, K.R.; Yan, T.; Methylation using dimethylcarbonate catalysed by ionic liquids under continuous flow conditions; Green Chem.; 2012; 14; 3071-3076

link to article

To top

Watts, P.; Wiles, C.; Micro reactors, flow reactors and continuous flow synthesis; Journal of Chemical Research; 2012; 36; 181-193

link to article

To top
Safe Generation and Synthetic Utilization of Hydrazoic Acid in a Continuous Flow Reactor

Gutmann, B.; Obermayer, D.; Roduit, J.P.; Roberge, D.M.; Kappe, C.O.; Safe Generation and Synthetic Utilization of Hydrazoic Acid in a Continuous Flow Reactor; Journal of Flow Chemistry; 2012; 2(1); 8–19

link to article

To top

Cukalovic, A.; Monbaliu, J.C.M.; Heynderickx, G.J.; Stevens, C.V.; User Friendly and Flexible Kiliani Reaction on Ketoses Using Microreaction Technology; Journal of Flow Chemistry; 2012; 2(2); 43-46

link to article

To top
Flash Flow Pyrolysis: Mimicking Flash Vacuum Pyrolysis in a High-Temperature/High-Pressure Liquid-Phase Microreactor Environmen

Cantillo, D.; Sheibani, H.; Kappe, C.O.; Flash Flow Pyrolysis: Mimicking Flash Vacuum Pyrolysis in a High-Temperature/High-Pressure Liquid-Phase Microreactor Environment; J. Org. Chem.; 2012; 77 (5); 2463–2473

link to article

To top
Rapid synthesis of substituted pyrrolines and pyrrolidines by nucleophilic ring closure at activated oximes

Chandan, N.; Thompson, A.; Moloney, M.G.; Rapid synthesis of substituted pyrrolines and pyrrolidines by nucleophilic ring closure at activated oximes; Org. Biomol. Chem.; 2012; 10; 7863-7868

link to article

To top

Saluste, G.; Albarran, M.I.; Alvarez, R.M.; Rabal, O.; Ortega, M.A.; Blanco, C.; Kurz, G.; Salgado, A.; Pevarello, P.; Bischoff, J.R.; Pastor, J.; Oyarzabal, J.; Fragment-Hopping-Based Discovery of a Novel Chemical Series of Proto-Oncogene PIM-1 Kinase Inhibitors; PLoS One; 2012; 7(10); e45964

link to article

To top
 Investigation, optimization and synthesis of sulfamoyloxy-linked aminoacyl-AMP analogues

Redwan, I.N.; Ljungdahl, T.; Grøtli, M.; Investigation, optimization and synthesis of sulfamoyloxy-linked aminoacyl-AMP analogues; Tetrahedron; 2012; 68(5); 1507-1514

link to article

To top
Total synthesis of (±)-monomorine

Le, T.Q.; Oliver, R.M.; Arcari, J.T.; Mitton-Fry, M.J.; Total synthesis of (±)-monomorine; Tetrahedron Letters; 2012; 53(42); 5660-5662

link to article

To top
A Continuous-Flow Approach to Palladium-Catalyzed Alkoxycarbonylation Reactions

Kelly, C.B.; Lee, C.(X.); Mercadante, M.A.; Leadbeater N.E.; A Continuous-Flow Approach to Palladium-Catalyzed Alkoxycarbonylation Reactions; Org. Process Res. Dev.; 2011; 15; 717–720

DOI: 10.1021/op200037n

Link to article

To top

Schön, M.; Schnürch, M.; Mihovilovic, M. D.; Application of continuous flow and alternative energy devices for 5-hydroxymethylfurfural production; Mol Divers; 2011; 15; 639–643

DOI: 10.1007/s11030-010-9295-9

Link to article

To top
A Continuous Flow System for Asymmetric Hydrogenation Using Supported Chiral Catalysts

Madarász, J.; Farkas, G.; Balogh, Sz.; Szöllősy, Á.; Kovács, J.; Darvas, F.; Ürge, L.; Bakos, J.; A Continuous.Flow System for Asymmetric Hydrogenation Using Supported Chiral Catalysts; J. Flow Chem.; 2011; 2; 62-67

DOI: 10.1556/jfchem.2011.00002

Link to article

To top
Reissert Indole Synthesis Using Continuous-Flow Hydrogenation

Colombo, E.; Ratel, P.; Mounier, L.; Guillier, F.; Reissert Indole Synthesis Using Continuous-Flow Hydrogenation; J. Flow Chem.; 2011; 2; 68-73

DOI: 10.1556/jfchem.2011.00009

Link to article

To top

Yap, A. J.; Chan, B.; Yuen,A. K. L.; Ward, A. J.; Masters, A. F.; Maschmeyer, T.; A Palladium-Catalyzed Multicascade Reaction: Facile Low-Temperature Hydrogenolysis of Activated Nitriles and Related Functional Groups; ChemCatChem; 2011; 3; 1496 – 1502

DOI: 10.1002/cctc.201100076

Link to article

To top
Novel phosphine-phosphites and their use in asymmetric hydrogenation

Farkas, G.; Balogh, Sz.; Szöllősy, Á.; Ürge, L.; Darvas, F.; Bakos, J.; Novel phosphine–phosphites and their use in asymmetric hydrogenation; Tetrahedron: Asymmetry; 2011; 22; 2104-2109

DOI: 10.1016/j.tetasy.2011.12.007

Link to article

To top

Lengyel, L.; Gyóllai, V.; Nagy, T.; Dormán, Gy; Terleczky, P.; Háda, V.; Nógrádi, K.; Sebők, F.; Ürge, L.; Darvas, F.; Stepwise aromatic nucleophilic substitution in continuous flow. Synthesis of an unsymmetrically substituted 3,5-diamino-benzonitrile library; Mol Divers; 2011; 15(3); 631 – 638

DOI: 10.1007/s11030-010-9300-3

Link to article

To top
Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries

Spencer, J.; Patel, H.; Callear, K.S.; Coles, S.J.; Deadman, J.J.; Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries; Tetrahedron Letters; 2011; 52; 5905-5909

DOI: 10.1016/j.tetlet.2011.07.147

Link to article

To top
Diacylglycerol synthesis by lipase- catalyzed partial hydrolysis of palm oil

Matos, L.M.C.; Leal, I.C.R.; de Souza, R.O.M.A.; Diacylglycerol synthesis by lipase- catalyzed partial hydrolysis of palm oil under microwave irradiation and continuous flow Conditions; Journal of Molecular Catalysis B: Enzymatic; 2011; 72; 36–39

DOI: 10.1016/j.molcatb.2011.04.021

Link to article

To top

Bryan, M.C.; Wernick, D.; Hein, C.D.; Petersen, J.V.; Eschelbach, J.W.; Doherty, E.M.; Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis; Beilstein J. Org. Chem.; 2011; 7; 1141–1149

DOI: 10.3762/bjoc.7.132

Link to article

To top
Copper-catalyzed rearragement of oximes into primary amides

Sharma, S.K.; Bishopp, S.D.; Allen, C.L.; Lawrence, R.; Bamford, M.J.; Lapkin, A.A.; Plucinski, P.; Watson, R.J.; Williams, J.M.J.; Copper-catalyzed rearragement of oximes into primary amides; Tetrahedron Letters; 2011; 52; 4252–4255

DIO: 10.1016/j.tetlet.2011.05.129

Link to article

To top
Microwave-Assisted and Continuous Flow Multistep Synthesis of 4-(Pyrazol-1-yl)carboxanilides

Obermayer, D.; Glasnov, T.N.; Kappe, O.C.; Microwave-Assisted and Continuous Flow Multistep Synthesis of 4-(Pyrazol-1-yl)carboxanilides; J. Org. Chem; 2011; 76; 6657-6669

DOI: 10.1021/jo2009824

Link to article

To top

Glasnov, T.N.; Kappe, O.C.; The Microwave-to-Flow Paradigm: Translating High-Temperature Batch Microwave Chemistry to Scalable Continuous Flow Processes; Chem. Eur. J.; 2011; 17; 11956 – 11968

DOI: 10.1002/chem.201102065

Link to article

To top

Brunner, B.; Elmer, S.; Schröder, F.; Transition-Metal-Catalyzed Cyclopropanation of Nonactivated Alkenes in Dibromomethane with Triisobutylaluminium; Eur. J. Org. Chem.; 2011; 4623–4633

DOI: 10.1002/ejoc.201100528

Link to article

To top

Orthaber, A.; Fuchs, M.; Belaj, F.; Rechberger, G.N.; Kappe, C.O.; Pietschnig, R.; Bis(diethylamino)(pentafluorophenyl)phosphane – a Push–Pull Phosphane Available for Coordination; Eur. J. Inorg. Chem.; 2011; 2588–2596

DOI: 10.1002/ejic.201100138

Link to article

To top

Ötvös, S.B.; Mándity, I.M.; Fülöp, F.; Highly selective deuteration of pharmaceutically relevant nitrogen-containing heterocycles: a flow chemistry approach; Mol Divers; 2011; 15; 605 – 611

Link to article

To top

Spencer, J.; Microwave chemistry enabling the synthesis of biologically relevant amines; Future Med. Chem.; 2010; 2(2); 161–168

DOI: 10.4155/FMC.09.114

Link to article

To top

Glasnov, T.N.; Kappe, C.O.; Continuous-Flow Syntheses of Heterocycles; J. Heterocyclic Chem.; 2011; 48; 11-30

DOI: 10.1002/jhet.568

Link to article

To top

Gutmann, B.; Glasnov, T.N.; Razzaq, T.; Goessler, W.; Roberge, D.M. and Kappe, C.O.; Unusual behavior in the reactivity of 5-substituted- 1H-tetrazoles in a resistively heated microreactor; Beilstein J. Org. Chem.; 2011; 7, 503–517

DOI: 10.3762/bjoc.7.59

Link to article

To top
Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki-Miyaura cross-couplings

Spencer, J.; Baltus, C.B.; Press, N.J.; Harrington, R.W.; Clegg, W.; Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki-Miyaura cross-couplings; Tetrahedron Letters; 2011; 52 (31); 3963–3968

DOI: 10.1016/j.tetlet.2011.05.025

Link to article

To top
Flow chemistry approach for partial deuteration of alkynes: synthesis of deuterated taxol side chain

Chandrasekhar, S.; Vijaykumar, B.V.D.; Mahesh Chandra, B.; Raji Reddy, Ch.; Naresh, P.; Flow chemistry approach for partial deuteration of alkynes: synthesis of deuterated taxol side chain; Tetrahedron Letters; 2011; 52; 3865-3867

DOI: 10.1016/j.tetlet.2011.05.042

Link to article

To top
A Scalable Two-Step Continuous Flow Synthesis of Nabumetone and Related 4-Aryl-2-butanones

Viviano, M.; Glasnov, T.N.; Reichard, B.; Tekautz, B.; Kappe, C.O.; A Scalable Two-Step Continuous Flow Synthesis of Nabumetone and Related 4-Aryl-2-butanones; Org. Process Res. Dev.; 2011; 15; 858-870

DOI: 10.1021/op2001047

Link to article

To top
Elucidation of a Structural Basis for the inhibitor-Driven, p62 (SQSTM1)-Dependent Intracellular Redistribution

Day, J.P.; Lindsay, B.; Riddel, T.; Jiang, Z.; Allock, R.W.; Abraham, A.; Sookup, S.; Christian, F.; Bogum, J.; Martin, E.K.; Rae, R.L.; Anthony, D.; Rosair, G.M.; Houslay, D.M.; Huston, E.; Baillie, G.S.; Klussmann, E.; Houslay, M.D.; Adams, D.R.; Elucidation of a Structural Basis for the inhibitor-Driven, p62 (SQSTM1)-Dependent Intracellular Redistribution of cAMP Phosphodiesterase-4A4 (PDE4A4); J. Med. Chem.; 2011; 54(9); 3331-3347

DOI: 10.1021/jm200070e

Link to article

To top
Dissection of Complex Molecular Recognition Interfaces

Hunter, C.A.; Misuraca, M.C.; Turega, S.M.; Dissection of Complex Molecular Recognition Interfaces; J. Am. Chem. Soc.; 2011; 133(3); 582-594

DOI: 10.1021/ja1084783

Link to article

To top
Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods

Baumann, M.; Baxendale, I.R.; Kuratli, C.; Ley, S.V.; Martin, R.E.; Schneider, J.; Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods; ACS Comb. Sci.; 2011; 13(4); 405-413

DOI: 10.1021/co2000357

Link to article

To top
Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles

Tarleton, M.; Gilbert, J; Robertson, J. M.; McCluskey, A.; Sakoff, A. J; Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound; MedChemComm; 2011; 2; 31-37

DOI: 10.1039/c0md00147c

Link to article

To top
3-Substituted xanthines as promising candidates for quadruplex formation: computational, synthetic and analytical studies

Szolomájer, J.; Paragi, G.; Batta, Gy.; Guerra, F. C.; Bickelhaupt, M. F.; Kele, Z.; Pádár, P.; Kupihár, Z.; Kovács, L.; 3-Substituted xanthines as promising candidates for quadruplex formation: computational, synthetic and analytical studies; New Journal of Chemistry; 2011; 35; 476–482

DOI: 10.1039/c0nj00612b

Link to article

To top
Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

Spencer, J.; Rathnam, P. R.; Harvey, L. A.; Clements, J. C.; Clark, L. R.; Barrett, P. M.; Wong, E. P.; Male, L.; Coles, J. S.; Mackay, P. S.; Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity; Bioorganic & Medicinal Chemistry; 2011; 19; 1802–1815

DOI: 10.1016/j.bmc.2011.01.010

Link to article

To top
A flow chemistry route to 2-phenyl-3-(1H-pyrrol-2-yl)propan-1-amines

Tarleton, M.; McCluskey, A.; A flow chemistry route to 2-phenyl-3-(1H-pyrrol-2-yl)propan-1-amines; Tetrahedron Letters; 2011; 52; 1583–1586

DOI: 10.1016/j.tetlet.2011.01.096

Link to article

To top
Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry

Ekholm, S. F.; Mándity, M. I.; Fülöp, F.; Leino, R.; Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry; Tetrahedron Letters; 2011; 52; 1839–1841

DOI: 10.1016/j.tetlet.2010.12.109

Link to article

To top

Irfan, M.; Glasnov, N. T.; Kappe, O. C.; Heterogeneous Catalytic Hydrogenation Reactions in Continuous-Flow Reactors; ChemSusChem; 2011;, 12 (3); 300–316

DOI: 10.1002/cssc.201000354

Link to article

To top
Continuous flow ozonolysis in a laboratory scale reactor

Irfan, M.; Glasnov, N. T.; Kappe, O. C.; Continuous flow ozonolysis in a laboratory scale reactor; Organic Letters; 2011; 13(5); 984-987

DOI: 10.1021/ol102984h

Link to article

To top
Reductive amination of ketones: novel one-step transfer hydrogenations in batch and continuous-flow mode

Falus, P.; Boros, Z.; Hornyánszky, G.; Nagy, J.; Darvas, F.; Ürge, L.; Poppe, L.; Reductive amination of ketones: novel one-step transfer hydrogenations in batch and continuous-flow mode; Tetrahedron Letters; 2011; 52; 1310–1312

DOI: 10.1016/j.tetlet.2011.01.062

Link to article

To top

Weinberg, L.R.; Albom, M.S.; Angeles, T.S.; Breslin, H.J.; Gingrich, D.E.; Huang, Z.; Lisko, J.G.; Mason, J.L.; Milkiewicz, K.L.; Thieu, T.V.; Underiner, T.L.; Wells, G.J.; Wells-Knecht, K.J.; Dorsey, B.D.; 2,7-Pyrrolo[2,1-f][1,2,4]triazines as JAK2 inhibitors: modification of target structure to minimize reactive metabolite formation; Bioorganic & Medicinal Chemistry Letters; 2011; 21(24); 7325 – 7330

DOI:10.1016/j.bmcl.2011.10.032

Link to article

To top
Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors

Andrés, J-I,; De Angelis, M.; Alcázar, J.; Iturrino, L.; Langlois, X.; Dedeurwaerdere, S.; Lenaerts, I.; Vanhoof, G.; Celen, S.; Bormans, G.; Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors as Candidates for Positron Emission Tomography Imaging; J. Med. Chem.; 2011; 54; 5820 – 5835

DOI 10.1021/jm200536d

Link to article

To top

Wilson, Z. E.; Hubert, J. G.; Brimble, M. A.; A Flexible Approach to 6,5-Benzannulated Spiroketals; Eur. J. Org. Chem.; 2011; 3938–3945

DOI 10.1002/ejoc.201100345

Link to article

To top
Synthesis of oxaspiropiperidines as a strategy for lowering logD

Cernak, T.;  Dykstra, K.; Levorse, D.; Verras, A.; Balkovec, J.; Nargund, R.; DeVita, R.; Synthesis of oxaspiropiperidines as a strategy for lowering logD; Synthesis of oxaspiropiperidines as a strategy for lowering logD; Tetrahedron Letters; 2011; 52; 6457-6459

DOI: 10.1016/j.tetlet.2011.09.100

Link to article

To top

Sperry, J.; Liu, Y-C.; Wilson, Z. E.; Hubert, J. G.; Brimble, M. A.; Synthesis of Benzannulated Spiroketals Using an Oxidative Radical Cyclization; Synthesis, 2011; 9; 1383-1398

link to article

To top
Adaptive Process Optimization for Continuous Methylation of Alcohol in Supercritical Carbon Dioxide

Bourne, R. A.; Skilton, R. A.; Parrott, A. J.; Irvinem D. J.; Poliakoff, M.; Adaptive Process Optimization for Continuous Methylation of Alcohol in Supercritical Carbon Dioxide; OPRD; 2011; 15(4); 932-938

DOI: 10.1021/op200109t

Link to article

To top
 Multijet Oscillating Disc Millireactor: A Novel Approach for Continuous Flow Organic Synthesis

Liguori, L.; Bjørsvik, H. R.; Multijet Oscillating Disc Millireactor: A Novel Approach for Continuous Flow Organic Synthesis; Org. Process Res. Dev.; 2011; 15(5); 997–1009

DOI: 10.1021/op2000699

Link to article

To top

Andrews, I.; Dunn, P.; Hayler, J.; Himkley, B.; Hughes, D.; Kaptein, B.; Lorenz, K.; Methew, S.; Rammeloo, T.; Wang, L.; Wells, A.; White, T.D.; Green Chemistry Articles of Interest to the Pharmaceutical Industry; Org. Process Res. Dev.; 2011; 15; 748-756

DOI: 10.1021/op200128q

Link to article

To top
 Combinatorial Chemistry Online

Terrett, N.K.; Combinatorial Chemistry Online; Comb Chem - An Online Journal; 2011; 13; 33–35

DOI: 10.1016/j.comche.2011.07.002

Link to article

To top
Recent advances in micro reaction technology

Wiles, C.; Watts, P.; Recent advances in micro reaction technology; Chemical Communications; 2011; 47(23); 6512-6535

link to article

To top

Vu, B. C.; Boyer, P. L.; Siddiqui, M. A.; Marquez, V. E.; Hughes, S. H.; 4'-C-Methyl-2'-Deoxyadenosine and 4'-C-Ethyl-2'-Deoxyadenosine Inhibit HIV-1 Replication; Antimicrob.Agents&Chemother.; 2011; 55(5); 2379-2389

link to article

To top
Microwave-Assisted Grafting to MCM-41 Silica and its Application as Catalyst in Flow Chemistry

Oliverio, M.; Procopio, A.; Glasnov, T. N.; Goessler, W.; Kappe, C. O.; Microwave-Assisted Grafting to MCM-41 Silica and its Application as Catalyst in Flow Chemistry; Aust.J.Chem.; 2011; 64; 1522-1529

link to article

To top
 Hydrogenation of Binary Mixtures of Activated Ketones on Pt-Alumina and on Pt-Alumina-Cinchonidine Catalysts

Szőllősi, Gy.; Makra, Zs.; Fülöp, F.; Bartók, M.; The First Case of Competitive Heterogeneously Catalyzed Hydrogenation using Continuous-Flow Fixed-Bed Reactor System: Hydrogenation of Binary Mixtures of Activated Ketones on Pt-Alumina and on Pt-Alumina-Cinchonidine Catalysts; Catalysis Letters; 2011; 141; 1616-1620

link to article

To top

Carter, C.F.; Lange, H.; Sakai, D.; Baxendale I.R.; Ley, S.V.; Diastereoselective Chain-Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly; Chem. Eur. J.; 2011; 17; 3398-3405

link to article

To top
A Two-Step Continuous-Flow Synthesis of N-(2-Aminoethyl)acylamides through Ring-Opening/Hydrogenation of Oxazolines

Gutmann, B.; Roduit, J.P.; Roberge, D.; Kappe, C.O.; A Two-Step Continuous-Flow Synthesis of N-(2-Aminoethyl)acylamides through Ring-Opening/Hydrogenation of Oxazolines; Chem. Eur. J.; 2011; 17; 13146 – 13150

link to article

To top
Cross-coupling in flow

Noel, T.; Buchwald, S.L.; Cross-coupling in flow; Chem. Soc. Rev.; 2011; 40; 5010–5029

link to article

To top
Stereoselective approaches to 2,3,6-trisubstituted piperidines. An enantiospecific synthesis of quinolizidine ()-217A

Mancey, N.C.; Sandon, N.; Auvinet, A.L.; Butlin, R.J.; Czechtizky, W.; Harrity, J.P.A.; Stereoselective approaches to 2,3,6-trisubstituted piperidines. An enantiospecific synthesis of quinolizidine ()-217A; Chem. Commun.; 2011; 47; 9804–9806

link to article

To top
A simple chemical model for clathrate hydrate inhibition by polyvinylcaprolactam

Davenport, J.R.; Musa, O.M.; Paterson, M.J.; Piepenbrock, M.O.M.; Fucke, K.; Steed, J.W.; A simple chemical model for clathrate hydrate inhibition by polyvinylcaprolactam; Chem. Commun.; 2011; 47; 9891–9893

link to article

To top

Kumari, N.; Olesen, J.K.; Pedersen, C.M.; Bols, M.; Synthesis of 5-Bromomethylfurfural from Cellulose as a Potential Intermediate
for Biofuel; Eur. J. Org. Chem.; 2011; 2011(7); 1266–1270

link to article

To top
Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences

Baumann, M.; Baxendale, I.R.; Kirschning, A.; Ley, S.V.; Wegner, J.; Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor; Heterocycles; 2011; 82(2); 1297-1316

link to article

To top

Danieli, E.; Proietti, D.; Berti, F.; Constantino, P.; Synthesis of Laminarin Fragments and Evaluation of a β-(1,3) Glucan Hexasaccaride-CRM197 Conjugate as Vaccine Candidate against Candida albicans; Journal of Carbohydrate Chemsitry; 2011; 30; 249-280

link to article

To top
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents

Coteron, J.M.; Marco, M.; Esquivias, J.; Deng, X.; White, K.L; White, J.; Koltun, M.; Mazouni, F.E.; Kokkonda, S.; Katneni, K.; Bhamidipati, R.; Shackleford, D.M.; Angulo-Barturen, I.; Ferrer, S.B.; Jiménez-Díaz, M.B.; Gamo, F.J.; Goldasmith, E.J.; Charman, W.N.; Bathurst, I.; Floyd, D.; Matthews, D.; Burrows, J.N.; Rathod, P.K.; Charman, S.A.; Philips, M.A; Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential; J. Med. Chem.; 2011; 54(15); 5540-5561

link to article

To top
Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase

Charrier, J.D.; Durrant, S.J.; Golec, J.M.; Kay, D.P., Knegtel, R.M.A.; MacCormick, S.; Mortimore, M.; O'Donnell, M.E.; Pinder, J.L.; Reaper, P.M.; Rutherford, A.P.; Wang, P.S.H.; Young, S.C.; Pollard, J.R.; Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents; J. Med. Chem.; 2011; 54(7); 2320-2330

link to article

To top

Baumann, M.; Baxendale, I.R.; Ley, S.v.; The flow synthesis of heterocycles for natural product and medicinal chemistry applications; Molecular Diversity; 2011; 15(3); 613-630

link to article

To top
Hydrothermal formose reaction

Kopetzki, D.; Antonietti, M.; Hydrothermal formose reaction; New J. Chem.; 2011; 35; 1787-1794

link to article

To top
 Synthesis of spirocyclic thiazolidinediones using ring-closing metathesis and one-pot sequential ring-closing/cross metathesis

Dhara, K.; Paladhi, S.; Midya, G.C.; Dash, J.; Synthesis of spirocyclic thiazolidinediones using ring-closing metathesis and one-pot sequential ring-closing/cross metathesis; Org. Biomol. Chem.; 2011; 9; 3801-3807

link to article

To top
 Synthesis of N-propynyl analogues of peptide nucleic acid (PNA) monomers and their use in a click reaction

Howarth, N.M.; Ricci, J.; Synthesis of N-propynyl analogues of peptide nucleic acid (PNA) monomers and their use in the click reaction to prepare N-functionalized PNAs; Tetrahedron; 2011; 67; 9588-9594

link to article

To top
A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core

Hay, D.A.; Adam, F.M.; Bish, G.; Calo, F.; Dixon, R.; Fray, M.J.; Hitchin, J.; Jones, P.; Paradowski, M.; Parsons, G.C.; Proctor, K.J.W.; Pryde, D.C.; Smith, N.N.; Tran, T.D.; A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core; Tetrahedron Letters, 2011, 52(44); 5728-5732

link to article

To top

Brice, H.; Clayden, J.; Hamilton, S.D.; Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation of the enolates of nicotyl-substitued esters and ketones; Beilstein J. Org. Chem.; 2010; 6; 22;

DOI: 10.3762/bjoc.6.22

Link to article

To top
Catalysis in flow: the practical and selective aerobic oxidation of alcohols to aldehydes and ketones

Zotova, N.; Hellgardt, K.; Kelsall, G. H.; Jessiman, A. S.; Hii, K. K.; Catalysis in flow: the practical and selective aerobic oxidation of alcohols to aldehydes and ketones; Green Chem.; 2010; 12; 2157–2163

DOI: 10.1039/c0gc00493f

Link to article

To top
Building β-Peptide H10/12 Foldamer Helices with Six-Membered Cyclic Side-Chains: Fine-Tuning of Folding and Self-Assembly

Mándity, M. I.; Fülöp, L.; Vass, E.; Tóth; K. G.; Martinek, A. T.; Fülöp, F.; Building β-Peptide H10/12 Foldamer Helices with Six-Membered Cyclic Side-Chains: Fine-Tuning of Folding and Self-Assembly, Organic Letters; 2010; 12 (23); 5584-5587

DOI: 10.1021/ol102494m

Link to article

To top

Glasnov, T.N.; Kappe; C.O.; Toward a Continuous-Flow Synthesis of Boscalid; Adv. Synth. Catal.; 2010; 352; 3089–3097

DOI: 10.1002/adsc.201000646

Link to article

To top
The synthesis of azabicyclic heterocycles

The synthesis of azabicyclic heterocycles; Darout, E.; Basak, A.; Tetrahedron Letters; 2010; 51; 2998-3001

DOI: 10.1016/j.tetlet.2010.03.123

Link to article

To top
Synthesis of functionalized 3-hydroxypiperidines

Wijdeven, M.A.; van Delft, F. L.; Rutjes, F. P. J. T.; Synthesis of functionalized 3-hydroxypiperidines; Tetrahedron; 2010; 66; 5623-5636

DOI: 10.1016/j.tet.2010.05.089

Link to article

To top

Borcard, F.; Baud, M.; Bello, C.; Dal Bello, G.; Grossi, F.; Pronzato, P.; Cea, M.; Nencioni, A.; Vogel, P.; Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity; Bioorg. Med. Chem. Lett.; 2010; 20; 5353-5356

DOI: 10.1016/j.bmcl.2009.09.019

Link to article

To top
Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2

Whelligan, D. K.; Solanki, S.; Taylor, D.; Thomson, D. W.; Cheung, K. J.; Boxall, K.; Mas-Droux, C.; Barillari, C.; Burns, S.; Grummitt, C. G.; Collins, I.; van Montfort, E. L. M.; Aherne, G. W.; Bayliss, R.; Hoelder, S.; Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization, J. Med. Chem.; 2010; 53; 7682-7698

DOI: 10.1021/jm1008727

Link to article

To top
Novel Spirotetracyclic Zwitterionic Dual H1/5-HT2A Receptor Antagonists for the Treatment of Sleep Disorders

Gianotti, M.; Botta, M.; Brough, S.; Carletti, R.; Castiglioni, E.; Corti, C.; Dal-Cin, M.; Fratte, S. D.; Korajec, D.; Lovric, M.; Merlo, G.; Mesic, M.; Pavone, F.; Piccoli, L.; Rast, S.; Roscic, M.; Sava, A.; Smehil, M.; Stasi, L.; Togninelli, A.; Wigglesworth, M. J.; Novel Spirotetracyclic Zwitterionic Dual H1/5-HT2A Receptor Antagonists for the Treatment of Sleep Disorders; J. Med. Chem.; 2010; 53; 7778-7795

DOI: 10.1021/jm100856p

Link to article

To top
Synthesis of a tetrasaccharide related to the triterpenoid saponin Bellisoside isolated from Bellis perennis (compositae)

Mandal, S.; Sharma, N.; Mukhopadhyay, B.; Synthesis of a tetrasaccharide related to the triterpenoid saponin Bellisoside isolated from Bellis perennis (compositae); Tetrahedron: Asymmetry; 2010; 21; 2172-2176

DOI: 10.1016/j.tetasy.2010.06.032

Link to article

To top
Reversal of the ee in enantioselective hydrogenation of activated ketones in continuous-flow fixed-bed reactor system

Cserenyi, Sz.; Szollosi, Gy.; Szori, K.; Fulop, F.; Bartok, M.; Reversal of the ee in enantioselective hydrogenation of activated ketones in continuous-flow fixed-bed reactor system; Catalysis Communication; 2010; 12; 14-19

DOI: 10.1016/j.catcom.2010.08.008

Link to article

To top
Straightforward hetero Diels-Alder reactions of nitroso dienophiles by microreactor technology

Monbaliu, J. M. R.; Cukalovic, A.; Marchand-Brynaert, J.; Stevens, C. V.; Straightforward hetero Diels-Alder reactions of nitroso dienophiles by microreactor technology; Tetrahedron Letters; 2010; 51; 5830-58

DOI: 10.1016/j.tetlet.2010.08.117

Link to article

To top

Tomin, A.; Hornyánszky, G.; Kupai, K.; Dorko, Zs.; Urge, L.; Darvas, F.; Poppe, L.; Lipase-catalyzed kinetic resolution of 2-methylene-substituted cycloalkanols in batch and continuous-flow modes; Process Biochemistry; 2010; 45; 859-865

DOI: 10.1016/j.procbio.2010.02.006

Link to article

To top

Brasholz, M.; Macdonald, J. M.; Saubern, S.; Ryan, J. H.; Holmes, A.B.; A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin; Chem. Eur. J., 2010; 16 (37); 11471-11480

DOI: 10.1002/chem.201001435

link to article

To top
The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist

Baur, F.; Beattie, D.; Beer, D.; Bentley, D.; Bradley, M.; Bruce, I.; Charlton, S. J.; Cuenoud, B.; Ernst, R.; Fairhurst, R. A.; Faller, B.; Farr, D.; Keller, T.; Fozard, J. R.; Fullerton, J.; Garman, S.; Hatto, J.; Hayden, C.; He, H.; Howes, C.; Janus, D.; Jiang, Z.; Lewis, C.; Loeuillet-Ritzler, F.; Moser, H.; Reilly, J.; Steward, A.; Sykes, D.; Tedaldi, L.; Trifilieff, A.; Tweed, M.; Watson, S.; Wissler, E.; Wyss, D.; The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist; J. Med. Chem.; 2010; 53; 3675-3684

DOI: 10.1021/jm100068m

Link to article

To top
Origin of the rate enhancement and enantiodifferentiation in the heterogeneous enantioselective hydrogenation

Szőllősi, Gy.; Cserényi, Sz.; Bucsi, I.; Bartók, T.; Fülöp, F.; Bartók, M.; Origin of the rate enhancement and enantiodifferentiation in the heterogeneous enantioselective hydrogenation of 2,2,2-trifluoroacetophenone over Pt/alumina studied in continuous-flow fixed-bed reactor system, Applied Catalysis A: General; 2010; 382; 263-271

DOI: 10.1016/j.apcata.2010.05.003

Link to article

To top
De Novo Design of a Picomolar Nonbasic 5-HT1B Receptor Antagonist

Nugiel, D.A.; Krumrine, J.R.; Hill, D.C.; Damewood, J.R.; Bernstein, P.R.; Sobotka-Briner, C.D.; Liu, J.W.; Zacco, A.; Pierson, M.E.; De Novo Design of a Picomolar Nonbasic 5-HT1B Receptor Antagonist; J. Med. Chem.; 2010; 53; 1876-1880

DOI: 10.1021/jm901200t

Link to article

To top
Synthesis of Unique Scaffolds via Diels-Alder Cycloadditions of Tetrasubstituated Cyclohexadienes

Jones, A. L.; Snyder, J.K.; Synthesis of Unique Scaffolds via Diels-Alder Cycloadditions of Tetrasubstituated Cyclohexadienes; Organic Letters, 2010; 12 (7); 1592-1595

DOI: 10.1021/ol100318f

Link to article

To top

Qian, Z.; Baxendale, I.R.; Ley, S.V.; A Flow Process Using Microreactors for the Preparation of a Quinolone Derivate as a Potent 5HT1B Antagonist; Synlett; 2010; 4; 505-508

DOI: 10.1055/s-0029-1219358

Link to article

To top

Razzaq, T., Kappe, O.C.; Continuous Flow Organic Synthesis under High-Temperature/Pressure Conditions; Chem. Asian J.; 2010; 5 (6); 1274-1289

DOI: 10.1002/asia.201000010

Link to article

To top

Fuchs, M.; Goessler, W.; Pilger, C.; Kappe, O.C.; Mechanistic Insights into Copper(I)-Catalyzed Azide-Alkyne Cycloadditions using Continuous Flow Conditions; Adv. Synth. Catal.; 2010; 352; 323-328

DOI: 10.1002/adsc.200900726

Link to article

To top
ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

Carter, C. F.; Lange, H.; Ley, S.V.; Baxendale, I. R.; Wittkamp, B.; Goode, J. G.; Gaunt, N. L.; ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing; Org. Process Res. Dev.; 2010; 14; 393-404

DOI: 10.1021/op900305v

Link to article

To top
Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes

Damm, M.; Glasnov, T.N.; Kappe, O.C.; Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes; Org. Process Res. Dev.; 2010; 14; 215-224

DOI: 10.1021/op900297e

Link to article

To top
Continuous flow multi-step organic synthesis

Webb, D.; Jamison, T. F.; Continuous flow multi-step organic synthesis; Chemical Science; 2010; 6; 675-680

DOI: 10.1039/C0SC00381F

Link to article

To top
Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane to Effect Gas-Liquid Contact

O’Brien, M.; Baxendale, I. R.; Ley, S. V.; Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane to Effect Gas-Liquid Contact; Organic Letters; 2010; 12 (7); 1596-1598

DOI: 10.1021/ol100322t

Link to article

To top

Lawrence, H. R.; Kazi, A.; Luo, Y.; Kendig, R.; Ge, Y., Jain, S.; Daniel, K.; Santiago, D.; Guida, W. C.; Sebti, S. M.; Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors; Bioorg. Med. Chem.; 2010; 18 (15); 5576-5592

DOI: 10.1016/j.bmc.2010.06.038

Link to article

To top
Oxazolomycins: Natural product lead structures for novel antibacterials by click fragment conjugation

Bagwell, C. L.; Moloney, M. G.; Yaqoob, M.; Oxazolomycins: Natural product lead structures for novel antibacterials by click fragment conjugation; Bioorg. Med. Chem. Lett.; 2010; 20; 2090-2094

DOI: 10.1016/j.bmcl.2010.02.066

Link to article

To top
Novel Evidence on the Role of the Nucleophilic Intermediate Complex in the fiorito-reaction

Szollosi, Gy.; Cserenyi, Sz.; Bartok, M.; Novel Evidence on the Role of the Nucleophilic Intermediate Complex in the fiorito-Reaction: Unexpected Inversion in the Enantioselective Hydrogenation of 2,2,2-Trifluoroacetophenone on Pt-Cinchona Chiral Catalyst Using Continuous-Flow Fixed-Bed Reactor; Catal. Lett.; 2010; 134; 264-269

DOI: 10.1007/s10562-009-0242-2

Link to article

 

To top
A facile, protic ionic liquid route to N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides

Gordon, C. P.; Byrne, N.; McCluskey, A., A facile, protic ionic liquid route to N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides and N-substituted 3-oxoisoindoline-4-carboxylic acids; Green Chem.; 2010; 12; 1000-1006

DOI 10.1039/b924835h

Link to article

To top
Transfer hydrogenation of levulinic acid under hydrothermal conditions catalyzed by sulfate as a temperature-switchable base

Kopetzki, D.; Antonietti, M.; Transfer hydrogenation of levulinic acid under hydrothermal conditions catalyzed by sulfate as a temperature-switchable base; Green Chem.; 2010; 12; 656–660

DOI 10.1039/b924648g

Link to article

 

 

To top

Zsigmond, Á.; Notheisz, F.; Kluson, P.; Floris, T.;  Chemoselective and Enantioselective Hydrogenations on Immobilized Complexes; Catalysis by Metal Complexes; 2010; 33; 283-359

DOI: 10.1007/978-90-481-3696-4_9

Link to article

To top
Diversity-Oriented Synthesis of Dibenzoazocines and Dibenzoazepines via a Microwave-Assisted Intramolecular A3-Coupling Reaction

Bariwal, J.B.; Ermolat’ev, D.S.; Glasnov, T.N.; Van Hecke, K.; Mehta, V.P.; Van Meervelt, L.; Kappe, C.O.; Van der Eycken, E.V.; Diversity-Oriented Synthesis of Dibenzoazocines and Dibenzoazepines via a Microwave-Assisted Intramolecular A3-Coupling Reaction; Org. Lett.; 2010; 12(12); 2774–2777

DOI: 10.1021/ol1008729

Link to article

To top
Intramolecular Aglycon Delivery Enables the Synthesis of 6‑Deoxy-β‑D-manno-heptosides

Kenfack, M. T.; Blériot, Y.; Gauthier, C.; Intramolecular Aglycon Delivery Enables the Synthesis of 6‑Deoxy-β‑D-manno-heptosides as Fragments of Burkholderia pseudomallei and Burkholderia mallei Capsular Polysaccharide; J. Org. Chem.; 2014; 79; 4615−4634

DOI: 10.1021/jo500640n

Link to article

To top

Kumar, C. S.S.R.; Nanotechnology tools in pharmaceutical R&D; Materials Today; 2010, 12; 24-30

link to article

To top

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions Using a Modular Flow Reactor; Synlett; 2010; 5; 749-752

DOI: 10.1055/s-0029-1219344

Link to article

To top
Synthesis and reactivity of 3-amino-1H-pyrazole[4,3-c]pyridine-4(5H)-ones: development of a novel kinase-focussed library

Smyth, L.A.; Matthews, T.P.; Horton, P.N.; Hursthouse, M.B.; Collins, I.; Synthesis and reactivity of 3-amino-1H-pyrazole[4,3-c]pyridine-4(5H)-ones: development of a novel kinase-focussed library; Tetrahedron; 2010; 66; 2843-2854

DOI: 10.1016/j.arabjc.2011.09.013

Link to article

To top

Spencer, J.; Research spotlight: Microwave chemistry enabling the synthesis of biologically relevant amines; Future Med. Chem; 2010; 2(2); 161-168

link to article

To top
Heterogeneous catalytic synthesis using microreactor technology

Frost, C. G.; Mutton, L.; Heterogeneous catalytic synthesis using microreactor technology; Green Chem.; 2010; 12; 1687-1703

link to article

To top
Microwave-Assisted Carbonylation and Cyclocarbonylation of Aryl Iodides under Ligand Free Heterogeneous Catalysis

Salvadori, J.; Balducci, E.; Zaza, S.; Petricci, E.; Taddei, M.; Microwave-Assisted Carbonylation and Cyclocarbonylation of Aryl Iodides under Ligand Free Heterogeneous Catalysis; J. Org. Chem.; 2010; 75(6); 1841-1847

link to article

To top
The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors

Carter, C. F.; Baxendale, I. R.; Pavey, J. B. J.; Ley, S. V.; The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors; Org. Biomol. Chem.; 2010; 8; 1588-1595

link to article

To top
The development of poly(dendrimer)s for advanced processing

Gunning, J. P.; Levell, J. W.; Wyatt, M. F.; Burn, P. L.; Robertson, J.; Samuel, I. D. W.; The development of poly(dendrimer)s for advanced processing; Polym. Chem.; 2010; 1; 730-738

link to article

To top

Liedl, E.; Beyer, A.; Wolschann, P.; Vierstein, H.; Interaction of β-Cyclodextrin with DNA-Bases; Sci Pharm.; 2010; 78(3); 590

link to article

To top

Jones, A. L.; Liu, X.; Snyder, J. K.; Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary; Tetrahedron Lett.; 2010; 51(7); 1091-1094

link to article

To top

Cukalovic, A.; Monbaliu, J. M. R.; Stevens, C. V.; Microreactor Technology as an Efficient Tool for Multicomponent Reactions; Top.Heterocycl.Chem.; 2010; 23; 161-198

link to article

To top
A Multistep Continuous-Flow System for Rapid On-Demand Synthesis of Receptor Ligands

Petersen, T.P.; Ritzen, A.; Ulven, T.; A Multistep Continuous-Flow System for Rapid On-Demand Synthesis of Receptor Ligands; Organic Letters; 2009; 11(22); 5134-5137

DOI: 10.1021/ol902101c

Link to article

To top
Synthesis of Bivalent Lactosides Based on Terephthalamide, N,N’-Diglucosylterephthalamide, and Glycophane Scaffolds

Leyden, R.; Velasco-Torrijos, T.; Andre, S.; Gouin, S.; Gabius, H.; Murphy, P.V.; Synthesis of Bivalent Lactosides Based on Terephthalamide, N,N’-Diglucosylterephthalamide, and Glycophane Scaffolds and Assessment of Their Inhibitory Capacity on Medically Relevant Lectins, J. Org. Chem.; 2009; 74; 9010-9026

DOI: 10.1021/jo901667r

Link to article

To top
An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process

An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process, Sedelmeier, J., Ley, S.V., Baxendale, I. R.; Green Chemistry, 2009; 11; 683-685

DOI: 10.1039/b821752a

Link to article

To top

Razzaq, T., Glasnov, T. N., Kappe, O. C.; Accessing Novel Process Windows in a High-Temperature/Pressure Capillary Flow Reactor; Chem. Eng. Technol.; 2009; 32(11); 1-6

DOI: 10.1002/ceat.200900272

Link to article

To top
Recycling the Waste: The Development of a Catalytic Wittig Reaction

O’Brien, C.J.; Tellez, J.L.; Nixon, Z. S.; Kang, L.J.; Carter, A. L.; Kunkel, S. R.; Przeworski, K.C.; Chass, G. A.; Recycling the Waste: The Development of a Catalytic Wittig Reaction; Angew. Chem. Int. Ed.; 2009; 48; 1-5

DOI: 10.1002/anie.200902525

Link to article

To top

Cho, K.; Ando, M.; Kobayashi, K.; Miyazoe, H.; Tsujino, T.; Ito, S.; Suzuki, T.; Tanaka, T.; Tokita, S.; Sato, N.; Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists; Bioorganic & Medicinal Chemistry Letters; 2009; 19(16); 4781-4785

DOI: 10.1016/j.bmcl.2009.06.050

Link to article

To top
Rearrangement of N-alkyl 1,2-amino alcohols. Synthesis of (S)-toliprolol and (S)-propanolol

Duthion, B.; Metro, T.; Padro, D., G.; Cossy, J.; Rearrangement of N-alkyl 1,2-amino alcohols. Synthesis of (S)-toliprolol and (S)-propanolol; Tetrahedron; 2009; 65(33); 6696-6709

DOI: 10.1016/j.tet.2009.05.072

Link to article

To top

Darvas, F.; Dormán, Gy.; Lengyel, L.; Kovács, I.; Jones, R.; Ürge, L.; High pressure, high temperature reactions in continuous flow: Merging discovery and process chemistry; Chemistry Today; 2009;, 27 (3); 40-43

Link to article

To top
A simple, efficient, and selective deuteration via a flow chemistry approach

Mándity, I.M.; Martinek, T.A.; Darvas, F.; Fülöp, F.; A simple, efficient, and selective deuteration via a flow chemistry approach; Tetrahedron Letters; 2009; 50; 4372–4374

DOI: 10.1016/j.tetlet.2009.05.050

Link to article

To top
New data in the enantioselective hydrogenation of ethyl pyruvate on Pt-cinchona chiral catalyst

Szollosi, Gy.; Cserenyi, Sz.; Balazsik, K.; Fulop, F.; Bartok, M.; New data in the enantioselective hydrogenation of ethyl pyruvate on Pt-cinchona chiral catalyst using continuous-flow fixed-bed reactor system: The origin of rate enhancement; Journal of Molecular Catalysis A: Chemical; 2009; 305; 155-160

DOI: 10.1016/j.molcata.2009.01.030

Link to article

To top
Pyrido[2,3-d]pyrimidin-5-ones:A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors

Huang, H.; Hutta, D.A.; Rinker, J.M.; Hu, H.; Parsons, W.H.; Schubert, C.; DesJarlais, R.L.; Crysler, C.S.; Chaikin, M.A.; Donatelli, R.P.; Chen, Y.; Cheng, D.; Zhou, Z.; Yurkow, E.; Manthey, C.L.; Player, M.R.; Pyrido[2,3-d]pyrimidin-5-ones:A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors; J.Med.Chem.; 2009; 52(4); 1081-1099

DOI: 10.1021/jm801406h

Link to article

To top
Double carbonylation of iodobenzene in a microfluidics-based high throughput flow reactor

Balogh, J.; Kuik, Á.; Ürge, L.; Darvas, F.; Bakos, J.; Skoda-Földes, R.; Double carbonylation of iodobenzene in a microfluidics-based high throughput flow reactor; Journal of Molecular Catalysis A: Chemical; 2009; 302; 76-79

DOI: 10.1016/j.molcata.2008.11.035

Link to article

To top
Construction of a Bicyclic β-Benzyloxi and β-Hydroxy Amide Library through a Multicomponent Cyclization

Zhang, L., Xiao, Q., Ma, C., Xie, X., Floreancig, P. E.; Construction of a Bicyclic β-Benzyloxi and β-Hydroxy Amide Library through a Multicomponent Cyclization Reaction; J. Comb. Chem.; 2009; 11(4); 640-644

DOI: 10.1021/cc800200h

Link to article

To top
Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor

Dong, S.; Hamel, E.; Bai, R.; Covell, D.G.; Beutler, J.A.; Porco, J.A.; Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor; Angew. Chem. Int. Ed.; 2009; 48 (8); 1494-1497

DOI: 10.1002/anie.200805486

Link to article

To top

Irfan, M.; Petricci, E.; Glasnov, T. N.; Taddei, M.; Kappe, O.C.; Continuous Flow Hydrogenation of Functionalized Pyridines; Eur. J. Org. Chem.; 2009; 9; 1327-1334

DOI: 10.1002/ejoc.200801131

Link to article

To top

Glasnov, T.N.; Findenig, S.; Kappe, O.C.; Heterogeneous Versus Homogeneous Palladium Catalysts for Ligandless Mizoroki-Heck Reactions: A Comparison of Batch/Microwave and Continuous-Flow Processing; Chem. Eur. J.; 2009; 15; 1001-1010

DOI: 10.1002/chem.200802200

Link to article

To top

Razzaq, T.; Glasnov, T.N.; Kappe, O. C.; Continuous-Flow Microreactor Chemistry under High-Temperature/Pressure Conditions; Eur. J. Org. Chem.; 2009; 9; 1321-1325

DOI: 10.1002/ejoc.200900077

Link to article

To top

Bhuiyan, M. D. H.; Mahon, A.B.; Jensen, P.; Clegg, J.K.; Try, A.C.; Synthesis of Symmetric Dinitro-Functionalized Tröger's Base Analogues; Eur. J. Org. Chem.; 2009; 5; 687-698

DOI: 10.1002/ejoc.200801032

Link to article

To top
Synthesis of a novel C2/C2’-aryl-substituated pyrrolo[2,1-c][1,4]benzodiazepine dimer produg

Howard, P. W., Chen, Z., Gregson, S. J., Masterson, L. A., Tiberghien, A. C., Cooper, N., Fang, M., Coffils, M. J., Klee, S., Hartley, J. A., Thurston, D.E.; Synthesis of a novel C2/C2’-aryl-substituated pyrrolo[2,1-c][1,4]benzodiazepine dimer produg with improved water solubility and reduced DNA reaction rate; Bioorg. Med. Chem. Lett.; 2009; 19(22); 6463-6466

DOI: 10.1016/j.bmcl.2009.09.012

Link to article

To top
Increasing Selectivity of CC Chemokine Receptor 8 Antagonists by Engineering Nondesolvation Related Interactions

Shamovsky, I. et al.; Increasing Selectivity of CC Chemokine Receptor 8 Antagonists by Engineering Nondesolvation Related Interactions with the Intended and Off-Target Binding Sites; J. Med. Chem.; 2009; 52; 7706-7723

DOI 10.1021/jm900713y

Link to article

 

To top
Synthesis of a Streptococcus pyogenes candidate based on the M protein PL1 epitope

Simerska, P.; Lu, H.; Toth, I.; Synthesis of a Streptococcus pyogenes candidate based on the M protein PL1 epitope; Bioorganic & Medicinal Chemistry Letters; 2009; 19(3); 821-824

link to article

To top

Barbaro, P.; Liguori, F.; Ion Exchange Resins: Catalyst Recovery and Recycle; Chem. Rev.; 2009; 109(2); 515–529

link to article

To top

Wiles, C.; Watts, P.; Continuous-flow organic synthesis: a tool for the modern medicinal chemist; Future Med Chem.; 2009; 1(9); 1593-1612

link to article

To top
Enantioselective Synthesis of Bicyclo[2.2.2]octenones

Dong, S; Zhu, J.; Porco, J.A.; Enantioselective Synthesis of Bicyclo[2.2.2]octenones Using a Copper-Mediated Oxidative Dearomatization/[4 + 2] Dimerization Cascade; J. Am. Chem. Soc.; 2008; 130(9); 2738-2739

DOI: 10.1021/ja711018z

Link to article

To top

Niesz, K.; Wootsch, A.; Otvos, Zs.; Darvas, F., Synthesis of Nanostructures on a Microfluidic-based Flow Device; MST News; 2008; 3(8); 30-31

Link to article

To top
Electrophile-Induced Dearomatizing Spirocyclization of N-Arylisonicotinamides: A Route to Spirocyclic Piperidines

Arnott, G.; Brice, H.; Clayden, J.; Blaney, E.; Electrophile-Induced Dearomatizing Spirocyclization of N-Arylisonicotinamides: A Route to Spirocyclic Piperidines; Organic Letters; 2008; 10(14); 3089-3092

DOI: 10.1021/ol801092s

Link to article

To top
High-Efficiency Aminocarbonylation by Introducing CO to a Pressurized Continuous Flow Reactor

Csajagi, Cs.; Borcsek, B., Niesz, K.; Kovacs, I.; Szekelyhidi, Zs.; Bajko, Z.; Ugre, L.; Darvas, F.; High Efficiency Aminocarbonylation by Introducing CO to a Pressurized Continuous Flow Reactor; Org. Lett.; 2008; 10 (8); 1589 - 1592

DOI: 10.1021/ol7030894

Link to article

To top

Balazsik, K., Cserenyi,  Sz., Szollosi, Gy., Fulop, F., Bartok, M.; New Data on the Orito Reaction: Effect of Substrate on Nonlinear Phenomenon; Catal. Lett.; 2008; 125; 401-407

DOI: 10.1007/s10562-008-9576-4

Link to article

To top

Jones, R. V.; Csajagi, Cs.; Szekelyhidi, Zs.; Kovacs, I.; Borcsek, B.; Urge, L.; Darvas, F.; Flow reactors for drug discovery Flow for reaction optimization, library synthesis, and scale up; Chemistry Today; 2008; 26(3); 10-13

Link to article

To top
Enantiomer selective acylation of racemic alcohols by lipases in continuous-flow bioreactors

Csajagi, Cs., Szatzker, G., Toke, E.R., Urge, L., Darvas, F., Poppe, L.; Enantiomer selective acylation of racemic alcohols by lipases in continuous-flow bioreactors; Tetrahedron: Asymmetry; 2008; 19(2); 237-246

DOI: 10.1016/j.tetasy.2008.01.002

Link to the article

To top

Niesz, K., Hornyak, I., Borcsek, B., Darvas, F., Nanoparticle synthesis completed with in situ catalyst preparation performed on a high-pressure high-temperature continuous flow reactor; Microfluidics and Nanofluidics; 2008; 1613-4982

DOI: 10.1007/s10404-008-0257-9

Link to the article

To top
High pressure in organic chemistry on the way to miniaturization

Benito-Lopez, F.; Egberink, E.J.M.; Reinhoudt, D.N.; Verboom, W.; High pressure in organic chemistry on the way to miniaturization; Tetrahedron; 2008; 64(43); 10023-10040

DOI: 10.1016/j.tet.2008.07.108

Link to article

To top

Ley, S.V.; Baxendale, I.R.; The Changing Face of Organic Synthesis; Chimia; 2008; 62 (3); 162-168

DOI: 10.2533/chimia.2008.162

Link to article

To top

Crow, J. M., Boosting the flow in pharma's pipelines; Chemistry World; 2008; 5 (6)

Link to article

To top
Construction and Validation of an Automated Flow Hydrogenation Instrument for Application in High-Throughput Organic Chemistry

Clapham, B.; Wilson, N.S.; Mischmerhuizen, M.J.; Blanchard, D.P.; Dingle, D.M.; Nemcek, T.A.; Pan, J.Y.; Sauer, D.R., Construction and Validation of an Automated Flow Hydrogenation Instrument for Application in High-Throughput Organic Chemistry; J. Comb. Chem.; 2008; 10; 88-93

DOI 10.1021/cc700178a

Link to article

To top

Szöllősi, Gy.; Cserényi, Sz.; Fülöp, F.; Bartók, M.; New data to the origin of rate enhancement on the Pt-cinchona catalyzed enantioselective hydrogenation of activated ketones using continuous-flow fixed-bed reactor system; Journal of Catalysis; 2008; 260(2); 245-253

DOI:10.1016/j.jcat.2008.10.004

Link to article

To top

Milroy, LG.; Zinzalla, G.; Loiseau, F.; Qian, Z.; Prencipe, G.; Pepper, C.; Fegan, C.; Ley, SV.; Natural-product-like spiroketals and fused bicyclic acetals as potential therapeutic agents for B-cell chronic lymphocytic leukaemia; ChemMedChem; 2008; 3; 1922-1935

link to article

To top
Using chemical probes to investigate the sub-inhibitory effects of azithromycin

Glansdorp, F. G.; Spandl, R. J.; Swatton, J. E.; Loiseleur, O.; Welch, M.; Spring, D. R.; Using chemical probes to investigate the sub-inhibitory effects of azithromycin; Org. Biomol. Chem.; 2008; 6; 4120-4124

link to article

To top
Synthesis of sugar-lactams from azides of glucuronic acid

Loukou, C.; Tosin, M.; Müller-Bunz, H.; Murphy, P. V.; Synthesis of sugar-lactams from azides of glucuronic acid; Carbohydrate Research; 2007; 342 (12-13); 1953-1959

DOI: 10.1016/j.carres.2007.04.003

Link to article

To top

Kovacs, I., Jones, R., Niesz, K., Csajagi, Cs.,  Borcsek, B., Darvas, F., Urge, L.; Automated Technology for Performing Flow-Chemistry at Elevated Temperature and Pressure; Journal of the Association for Laboratory Automation; 2007; 12 (5); 284-290

DOI: 10.1016/j.jala.2007.06.009

Link to the article

To top
Enantioselective hydrogenation of α,ß-unsaturated carboxylic acids in fixed-bed reactor

Herman, B., Szollosi, Gy., Fulop F., Bartok, M.; Enantioselective hydrogenation of α,ß-unsaturated carboxylic acids in fixed-bed reactor; Applied Catalysis A: General; 2007; 331; 39-43

DOI: 10.1016/j.apcata.2007.07.022

Link to article

To top

Knudsen, K.R.; Holde, J.; Ley, S.V.; Ladlow, M.; Optimisation of Conditions for O-benzyl and N-Benzyloxycarbonyl Protecting Group removal using an Automated Flow Hydrogenator; Adv. Synth. Catal.; 2007; 349; 535-538

DOI: 10.1002/adsc.200600558

Link to the article

To top
Mesoscale Flow Chemistry: A Plug-Flow Approach to reaction Optimisation

Wheeler, R.C.; Benali, O.; Deal, M.; Farrant, E.; MacDonald, S.J.F.; Warrington, B.H.; Mesoscale Flow Chemistry: A Plug-Flow Approach to reaction Optimisation; Org. Process Res. Dev.; 2007; 11; 704-710

DOI: 10.1021/op7000707

Link to the article

To top

Horvath, H., H., Papp, G., Csajagi, Cs., Joó, F.; Selective catalytic hydrogenations in a microfluidics-based high-throughput flow reactor on ion-exchange supported transition metal complexes: A modular approach to the heterogenization of soluble complex catalyst; Cat. Comm., 2007; 8; 442-446

DOI: 10.1016/j.catcom.2006.07.016

Link to the article

To top
Asymmetric Mannich Reaction of Dicarbonyl Compounds with α-Amido Sulfones Catalyzed by Cinchona Alkaloids

Lou, S., Dai, P., Schaus, S.E., Asymmetric Mannich Reaction of Dicarbonyl Compounds with α-Amido Sulfones Catalyzed by Cinchona Alkaloids and Synthesis of Chiral Dihydropyrimidones; J. Org. Chem; 2007; 72; 9998-10008

DOI: 10.1021/jo701777g

Link to the article

To top
Synthesis of macroline-saccharide hybrids by ring-closing metathesis of precursors derived from glycitols and benzoic acids

Matos, M and Murphy, P., V.; Synthesis of macroline-saccharide hybrids by ring-closing metathesis of precursors derived from glycitols and benzoic acids; J. Org. Chem.; 2007; 72; 1803-1806

DOI: 10.1021/jo062159l

Link to the article

To top
Synthesis of tetrazole analogues of amino acids using Fmoc chemistry

Sureshbabu, V.V.; Venkataramanarao, R.; Naik, S.A.; Chennakirshnareddy, G.; Synthesis of tetrazole analogues of amino acids using Fmoc chemistry: isolation of amino free tetrazoles and their incorporation into peptides; Tetrahedron Letters; 2007; 48(39); 7038-7041

DOI: 10.1016/j.tetlet.2007.07.129

link to article

To top

Chighine, A.; Sechi, G., Bradley, M.; Tools for efficient high-throughput synthesis; Drug Discovery Today; 2007; 12 (11/12); 459-464

DOI: 10.1016/j.drudis.2007.04.004

Link to the article

To top
Some Items of Interest to Process R&D Chemists and Engineers

McLaughlin, M.; Rubio, S. G.; Tilstam, U.; Antunes, O. A. C.; Laird, T.; Zlota, A.; Some Items of Interest to Process R&D Chemists and Engineers; Organic Process Research & Development; 2007; 11; 652-662

DOI: 10.1021/op700143p

Link to the article

To top

Niesz, K.; Csajagi, Cs.; Borcsek, B.; Jones, R. V.; Darvas, F.; Interesting applications on a novel high pressure high temperature microfluidic-based flow reactor; Nanotechnology; 2007; 4; 426-429

link to article

To top

Spadoni, C; Jones, R.; Urge, L.; Darvas, F.; Scaling up and validation of hydrogenation reactions using a continuous-flow microfluidics-based reactor, H-Cube®; Chem. Today; February/March 2006; 38-41

Link to the article

To top
Continuous-flow high pressure hydrogenation reactor for optimization and high-throughput synthesis

Jones, R., Godorhazy, L., Varga, N., Szalay, D., Gerencser, J.; Dorman, Gy.; Urge, L., and Darvas, F.; Continuous-flow high pressure hydrogenation reactor for optimization and high-throughput synthesis; J. Comb. Chem.; 2006; 8(1); 110-116

DOI: 10.1021/cc050107o

Link to the article

To top

Szollosi, Gy., Herman, B., Fulop, F., and Bartok, M.; Continuous enantioselective hydrogenation of activated ketones on a pt-cd chiral catalyst: use of H-cube reactor system; Reaction Kinetics and Catalysis Letters; 2006; 88(2); 391-398

Link to the article

To top

Franckevicius, V, Knudsen, K.R., Ladlow, M., Longbottom, D.A.  and Ley, S.V.; Practical Synthesis of (S)-Pyrrolidin-2-yl-1H-tetrazole, Incorporating Efficient Protecting Group Removal by Flow-reactor Hydrogenolysis; Synlett; 2006; 6; 889-892

DOI: 10.1055/s-2006-939036

Link to the article

To top

Kirschning, A. Solodenko, W. Mennecke, K.; Combining Enabling Techniques in Organic Synthesis: Continuous Flow Process with Heterogenized Catalysts; Chem. Eur. J.; 2006; 12(23); 5972-5990

DOI: 10.1002/chem.200600236

Link to article

To top

Thurow, K.; Weinmann, H.; Automation Highlights from Literature; Journal of the Association for Laboratory Automation; 2006; 11 (4); 167-171

DOI: 10.1016/j.jala.2006.10.012

Link to article

To top

Kündig, P.; The Future of Organic Synthesis; Science; 2006; 314; 430-431

Link to the article

To top

Koppitz, M., Eis, K., Automated Medicinal Chemistry; Drug Discovery Today; 2006; 11(11/12); 561-568

Link to the article

To top
A Flow Process for the Multi-Step Synthesis of the Alkaloid Natural Product Oxomaritidine

Baxendale, I.R., Deeley, J., Griffiths-Jones, C.M.,  Ley, S.V., Saaby, S. and Tranmer, G.; A Flow Process for the Multi-Step Synthesis of the Alkaloid Natural Product Oxomaritidine: A New Paradigm for Molecular Assembly; J. Chem. Soc., Chem. Commun.; 2006; 2566-2568.

DOI: 10.1039/b600382f

Link to article

To top
A flow reactor process for the synthesis of peptides utilizing immobilized reagents

Baxendale, I.R.; Ley, S.V.; Smith, C.D.; Tranmer, G.K.; A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols; Chem. Commun.; 2006; 4835-4837

DOI: 10.1039/B612197G

Link to the article

To top

Ritter, S., Natural product synthesis on the fly. Multistep continuous reaction shows the power of automated flow synthesis; Chemical&Engineering News; 2006; 84(10); 17

Link to the article

To top
Microfluidics in commercial applications; an industry perspective

Microfluidics in commercial applications; an industry  perspective; Lab Chip; 2006; 6; 1118-1121

Link to the article

To top
 Microwave-Assisted Solution Phase Synthesis of Dihydropyrimidine C5 Amides and Esters

Desai, B.; Dallinger, D.; Kappe, C.O., Microwave-Assisted Solution Phase Synthesis of Dihydropyrimidine C5 Amides and Esters; Tetrahedron; 2006; 62; 4651-4664

DOI: 10.1016/j.tet.2005.12.061

Link to article

To top

Desai, B. and Kappe, O.; Heterogeneous hydrogenation reactions using a continuous flow high pressure device; Journal of Combinatorial Chemistry; 2005; 7(5); 641-643

DOI: 10.1021/cc050076x

Link to the article

To top
How to use continuous flow reactors for the efficient reduction of imines to amines

Saaby, S., Knudsen, K.R., Ladlow, M., Ley, S.V.; The use of a continuous-flow reactor employing a mixed hydrogen-liquid flow steam for the efficient reduction of imines to amines; Chemical Communication; 2005; 23; 2909-11

link to the article

To top

Spadoni, S., Jones, R., Urge, L. and Darvas, F.; The recent advancement of hydrogenation technology and their implications for drug discovery research; Chem. Today, January/February 2005; 36-39

Link to the article

To top

Jones, R., Godorhazy, L., Szalay, D., Gerencser, J., Dorman, Gy., Urge, L., Darvas, F.; A novel method for high-throughput reduction of compounds through automated sequential injection into a continuous-flow microfluidic reactor; QSAR Comb. Sci.; 2005; 24(6); 722-727

DOI: 10.1002/qsar.200540006

Link to the article

To top