Publications

Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors

Lawrence, H. R.; Martin, M.P.; Luo, Y.; Pireddu, R.; Yang, H.; Gevariya, H.; Ozcan, S.; Zhu, J.Y.; Kendig, R.; Rodriguez, M.; Elias, R.; Cheng, J.Q.; Sebti, S.M.; Schonbrunn, E.;Lawrence, N.J.; Development of o-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors; J. Med. Chem., 2012; 55 (17); 7392-7416

DOI: 10.1021/jm300334d

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Synthesis of Phenols via Fluoride-free Oxidation of Arylsilanes and Arylmethoxysilanes

Rayment, E. J.; Summerhill, N.; Anderson, E. A.; Synthesis of Phenols via Fluoride-free Oxidation of Arylsilanes and Arylmethoxysilanes;  J. Org. Chem.; 2012; 77 (16); 7052-7060

DOI: 10.1021/jo301363h

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First Enantioselective Total Synthesis of (+)-(R)-Pinnatolide Using an Asymmetric Domino Allylation Reaction

Tietze, L. F.; Wolfram, T.; Holstein, J. J.; Dittrich, B.; First Enantioselective Total Synthesis of (+)-(R)-Pinnatolide Using an Asymmetric Domino Allylation Reaction; Org. Lett.; 2012; 14 (16); 4035-4037 

DOI: 10.1021/ol301932d

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Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor-Selective Agonists

Furmick, J. K.; Kaneko,I.; Walsh, A. N.; Yang,J.; Bhogal, J. S.; Gray, G. M.; Baso, J. C.; Browder, D. O., Prentice, J. L. S.; Montano, L A.; Huynh, C. C. Marcus, L. M.; Tsosie, D. G.; Kwon, J. S.; Quezada, A.; Reyes, N. M.; Lemming, B.; Saini, P.; van der Vaart, A.; Groy, T. L.;  Marshall, P. A.; Jurutka, P. W.; Wagner, C. E.; Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor-Selective Agonists: Novel Halogenated Analogues of 4-[1-(3,5,5,8,8-Pentamethyl- 5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene); ChemMedChem; 2012; 7; 1551-1566

DOI: 10.1002/cmdc.201200319

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A Method to Identify Best Available Technologies (BAT) for Hydrogenation Reactors in the Pharmaceutical Industry

Doan, T.; Stavárek, K.; Bellefon, C.; A Method to Identify Best Available Technologies (BAT) for Hydrogenation Reactors in the Pharmaceutical Industry; J. Flow Chem.; 2012; 2(3); 77-82

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Synthesis and arylation of unprotected sulfonimidamides

Maldonado; M. F.; Sehgelmeble, F.; Bjarnemark, F.; Svensson, M.; Ahman, F.;Arvidsson, P. I.; Synthesis and arylation of unprotected sulfonimidamides; Tetrahedron; 2012; 68; 7456-7462

DOI: 10.1016/j.tet.2012.06.072

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Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state

Baltus, C. B.; Press, N. J.; Antonijevic, M. D.; Tizzard, G. J.; Coles, S. J.; Spencer, J.; Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state; Tetrahedron; 2012; 68 (45); 9272-9277

DOI: 10.1016/j.tet.2012.08.062

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Efficient and scalable synthesis of thiazole fused benzazepine as a D2 partial agonist

Xiong, H.; Wu, Y.; Lehr, S. G.; Blackwell, W.; Steelman, G.; Hulsizer, J.; Urbanek, R. A.; Efficient and scalable synthesis of thiazole fused benzazepine as a D2 partial agonist; Tetrahedron Letters; 2012; 53 (44); 5833-5836

DOI: 10.1016/j.tetlet.2012.08.035

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Reductive Amination by Continuous-Flow Hydrogenation: Direct and Scalable Synthesis of a Benzylpiperazine

Liu, J.; Fitzgerald, A. E.; Mani, N. S.; Reductive Amination by Continuous-Flow Hydrogenation: Direct and Scalable Synthesis of a Benzylpiperazine; Synthesis; 2012; 44 (15); 2469-2473

DOI: 10.1055/s-0032-1316550

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Process Development of a Potent Glucosylceramide Synthase Inhibitor

Cooper, C. G. F.; Lee, E. R.; Silva, R. A.; Bourque, A. J.; Clark, S.; Katti, S.; Nivorozkhin, V.; Process Development of a Potent Glucosylceramide Synthase Inhibitor; Org. Process Res. Dev.; 2012; 16 (5); 1090-1097

DOI: 10.1021/op2001222

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Continuous Flow Synthesis. A Pharma Perspective

Malet-Sanz, L.; Susanne, F.; Continuous Flow Synthesis. A Pharma Perspective; J. Med. Chem.; 2012; 55 (9); 4062-4098

DOI: 10.1021/jm2006029

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Synthesis of Amines from Alcohols in a Nonepimerizing One-Pot Sequence – Synthesis of Bioactive Compounds

Guerin, C.; Bellosta, V.; Guillamot, G.; Cossy, J.; Synthesis of Amines from Alcohols in a Nonepimerizing One-Pot Sequence - Synthesis of Bioactive Compounds: Cinacalcet and Dexoxadrol; Eur. J. Org. Chem.; 2012; 15; 2990-3000

Doi: 10.1002/ejoc.201200171

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Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states

Dayde, B.; Benzaria, S.; Pierra, C.; Gosselin, G.; Surleraux, D.; Volle, J.; Pirat, J.; Virieux, D.; Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states; Org. Biomol. Chem.; 2012, 10, 3448-3454

DOI: 10.1039/c2ob25131k

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Using Continuous Processes to Increase Production

Anderson, N. G.; Using Continuous Processes to Increase Production; Org. Proc. Res. Dev.; 2012; 16(5); 852-869

DOI: 10.1021/op200347k

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Diastereoselective 1,3-Dipolar Cycloaddition of Pyrylium Ylides with Chiral Enamides

Tchabanenko, K.; Sloan, C.; Bunetel, Y.; Mullen, P.; Diastereoselective 1,3-Dipolar Cycloaddition of Pyrylium Ylides with Chiral Enamides; Organic and Bioorganic Chemistry; 2012; 10; 4215-4219

DOI: 10.1039/c0xx00000x

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Stereocontrolled Synthesis of the cis-Hydroxydecalin System: Towards Biologically Active 19-nor-Clerodanes

Mirzayans, P. M.; Pouwer, R. H.; Williams, C. M.; Bernhardt, P. V.; Stereocontrolled Synthesis of the cis-Hydroxydecalin System: Towards Biologically Active 19-nor-Clerodanes; Eur. J. Org. Chem.; 2012; 1633-1638

DOI: 10.1002/ejoc.201101807

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Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

Battilocchio, C.; Baumann, M.; Baxendale, I. R.; Biava, M.; Kitching, M. O.; Ley, S. V.; Martin, R. E.; Ohnmacht, S. A.; Tappin, N. D. C.; Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands; Synthesis; 2012; 44; 635-647

DOI: 10.1055/s-0031-1289676

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Synthesis and biological characterization of sirtuin inhibitors based on the tenovins

McCarthy, A. R.; Pirrie, L.; Hollick, J. J.; Ronseaux, S.; Campbell, J.; Higgins, M.; Staples, O. D.; Tran, F.; Slawin, A. M. Z.; Lain, S.; Westwood, N. J.; Synthesis and biological characterization of sirtuin inhibitors based on the tenovins; Bioorg. Med. Chem.; 2012; 20; 1779-1793

DOI: 10.1016/j.bmc.2012.01.001

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Reagent-controlled stereoselective synthesis of (±)-gallo- and (±)-epigallo-catechin gallates

Tanaka, H.; Chino, A.; Takahashi, T.; Reagent-controlled stereoselective synthesis of (±)-gallo- and (±)-epigallo-catechin gallates; Tetrahedron Letters; 2012; 53; 2493-2495

DOI: 10.1016/j.tetlet.2012.02.065

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A Continuous Flow System for Asymmetric Hydrogenation Using Supported Chiral Catalysts

Madarász, J.; Farkas, G.; Balogh, Sz.; SzöllÅ‘sy, Á.; Kovács, J.; Darvas, F.; Ürge, L.; Bakos, J.; A Continuous.Flow System for Asymmetric Hydrogenation Using Supported Chiral Catalysts; J. Flow Chem.; 2011; 2; 62-67

DOI: 10.1556/jfchem.2011.00002

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Reissert Indole Synthesis Using Continuous-Flow Hydrogenation

Colombo, E.; Ratel, P.; Mounier, L.; Guillier, F.; Reissert Indole Synthesis Using Continuous-Flow Hydrogenation; J. Flow Chem.; 2011; 2; 68-73

DOI: 10.1556/jfchem.2011.00009

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Fatty acids residue from palm oil refining process as feedstock for lipase catalyzed monoacylglicerol production under batch

Junior, I. I.; Flores, M. C.; Sutili, F. K.; Leite, S. G. F.; de M. e Miranda, L.; Leal, I. C. R.; de Souza, R. O. M. A.; Fatty acids residue from palm oil refining process as feedstock for lipase catalyzed monoacylglicerol production under batch and continuous flow conditions; Journal of Molecular Catalysis B: Enzymatic; 2012; 77; 53-58

DOI: 10.1016/j.molcatb.2012.01.008

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Asymmetric hydrogenation of C-C double bonds using Rh-complex under homogeneous, heterogeneous and continuous mode conditions

Balogh Sz.; Farkas, G.; Madarász, J.; SzöllÅ‘sy, Á.; Kovács, J.; Darvas, F.; Ürge L.; Bakos, J.; Asymmetric hydrogenation of C-C double bonds using Rh-complex under homogeneous, heterogeneous and continuous mode conditions; Green Chem.; 2012; 14; 1146-1151

DOI: 10.1039/c2gc16447g

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Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library

Spencer, J.; Patel, H.; Amin, J.; Callear, S. K.; Coles, S. J.; Deadman, J. J.;Furman, C.; Mansouri, R.; Chavatte, P.; Millet, R.; Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library; Tetrahedron Letters; 2012; 53; 1656-1659

DOI: 10.1016/j.tetlet.2012.01.081

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Highly Efficient 1,4-Addition of Aldehydes to Nitroolefins

Ötvös, S. B.; Mándity, I. M.; Fülöp, F.; Highly Efficient 1,4-Addition of Aldehydes to Nitroolefins: Organocatalysis in Continuous Flow by Solid-Supported Peptidic Catalysts; ChemSusChem; 2012; 5; 266 - 269

DOI: 10.1002/cssc.201100332

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Parallel synthesis of 1,2,4-triazole derivatives using microwave and continuous-flow techniques

Szommer T.; Lukács A.; Kovács J.; Szabó M. J.;Hoffmann M. G.; Schmitt M. H.; Gerencsér J.; Parallel synthesis of 1,2,4-triazole derivatives using microwave and continuous-flow techniques; Mol Divers.; 2012; 16(1); 81-90

DOI: 10.1007/s11030-012-9357-2

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Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow

Lengyel, L.; Nagy, T. Zs.; Sipos, G.; Jones, R.; Gorman, Gy.; Ürge, L.; Darvas, F.; Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives; Tetrahedron Letters; 2012; 53; 738-743

DOI: 10.1016/j.tetlet.2011.11.125

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A Palladium-Catalyzed Multicascade Reaction: Facile Low-Temperature Hydrogenolysis of Activated Nitriles

Yap, A. J.; Chan, B.; Yuen,A. K. L.; Ward, A. J.; Masters, A. F.; Maschmeyer, T.; A Palladium-Catalyzed Multicascade Reaction: Facile Low-Temperature Hydrogenolysis of Activated Nitriles and Related Functional Groups; ChemCatChem; 2011; 3; 1496 - 1502

DOI: 10.1002/cctc.201100076

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Novel phosphine-phosphites and their use in asymmetric hydrogenation

Farkas, G.; Balogh, Sz.; SzöllÅ‘sy, Á.; Ürge, L.; Darvas, F.; Bakos, J.; Novel phosphine-phosphites and their use in asymmetric hydrogenation; Tetrahedron: Asymmetry; 2011; 22; 2104-2109

DOI: 10.1016/j.tetasy.2011.12.007

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Stepwise aromatic nucleophilic substitution in continuous flow

Lengyel, L.; Gyóllai, V.; Nagy, T.; Dormán, Gy; Terleczky, P.; Háda, V.; Nógrádi, K.; SebÅ‘k, F.; Ürge, L.; Darvas, F.; Stepwise aromatic nucleophilic substitution in continuous flow. Synthesis of an unsymmetrically substituted 3,5-diamino-benzonitrile library; Mol Divers; 2011; 15(3); 631 - 638

DOI: 10.1007/s11030-010-9300-3

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Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries

Spencer, J.; Patel, H.; Callear, K.S.; Coles, S.J.; Deadman, J.J.; Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries; Tetrahedron Letters; 2011; 52; 5905-5909

DOI: 10.1016/j.tetlet.2011.07.147

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Diacylglycerol synthesis by lipase- catalyzed partial hydrolysis of palm oil

Matos, L.M.C.; Leal, I.C.R.; de Souza, R.O.M.A.; Diacylglycerol synthesis by lipase- catalyzed partial hydrolysis of palm oil under microwave irradiation and continuous flow Conditions; Journal of Molecular Catalysis B: Enzymatic; 2011; 72; 36-39

DOI: 10.1016/j.molcatb.2011.04.021

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Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis

Bryan, M.C.; Wernick, D.; Hein, C.D.; Petersen, J.V.; Eschelbach, J.W.; Doherty, E.M.; Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis; Beilstein J. Org. Chem.; 2011; 7; 1141-1149

DOI: 10.3762/bjoc.7.132

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Copper-catalyzed rearragement of oximes into primary amides

Sharma, S.K.; Bishopp, S.D.; Allen, C.L.; Lawrence, R.; Bamford, M.J.; Lapkin, A.A.; Plucinski, P.; Watson, R.J.; Williams, J.M.J.; Copper-catalyzed rearragement of oximes into primary amides; Tetrahedron Letters; 2011; 52; 4252-4255

DIO: 10.1016/j.tetlet.2011.05.129

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Microwave-Assisted and Continuous Flow Multistep Synthesis of 4-(Pyrazol-1-yl)carboxanilides

Obermayer, D.; Glasnov, T.N.; Kappe, O.C.; Microwave-Assisted and Continuous Flow Multistep Synthesis of 4-(Pyrazol-1-yl)carboxanilides; J. Org. Chem; 2011; 76; 6657-6669

DOI: 10.1021/jo2009824

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The Microwave-to-Flow Paradigm: Translating High-Temperature Batch Microwave Chemistry to Scalable Continuous Flow Processes

Glasnov, T.N.; Kappe, O.C.; The Microwave-to-Flow Paradigm: Translating High-Temperature Batch Microwave Chemistry to Scalable Continuous Flow Processes; Chem. Eur. J.; 2011; 17; 11956 - 11968

DOI: 10.1002/chem.201102065

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Transition-Metal-Catalyzed Cyclopropanation of Nonactivated Alkenes in Dibromomethane with Triisobutylaluminium

Brunner, B.; Elmer, S.; Schröder, F.; Transition-Metal-Catalyzed Cyclopropanation of Nonactivated Alkenes in Dibromomethane with Triisobutylaluminium; Eur. J. Org. Chem.; 2011; 4623-4633

DOI: 10.1002/ejoc.201100528

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Bis(diethylamino)(pentafluorophenyl)phosphane – a Push-Pull Phosphane Available for Coordination

Orthaber, A.; Fuchs, M.; Belaj, F.; Rechberger, G.N.; Kappe, C.O.; Pietschnig, R.; Bis(diethylamino)(pentafluorophenyl)phosphane - a Push-Pull Phosphane Available for Coordination; Eur. J. Inorg. Chem.; 2011; 2588-2596

DOI: 10.1002/ejic.201100138

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Highly selective deuteration of pharmaceutically relevant nitrogen-containing heterocycles: a flow chemistry approach

Ötvös, S.B.; Mándity, I.M.; Fülöp, F.; Highly selective deuteration of pharmaceutically relevant nitrogen-containing heterocycles: a flow chemistry approach; Mol Divers; 2011; 15; 605 - 611

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Microwave chemistry enabling the synthesis of biologically relevant amines

Spencer, J.; Microwave chemistry enabling the synthesis of biologically relevant amines; Future Med. Chem.; 2010; 2(2); 161-168

DOI: 10.4155/FMC.09.114

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Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation

Brice, H.; Clayden, J.; Hamilton, S.D.; Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation of the enolates of nicotyl-substitued esters and ketones; Beilstein J. Org. Chem.; 2010; 6; 22;

DOI: 10.3762/bjoc.6.22

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Catalysis in flow: the practical and selective aerobic oxidation of alcohols to aldehydes and ketones

Zotova, N.; Hellgardt, K.; Kelsall, G. H.; Jessiman, A. S.; Hii, K. K.; Catalysis in flow: the practical and selective aerobic oxidation of alcohols to aldehydes and ketones; Green Chem.; 2010; 12; 2157-2163

DOI: 10.1039/c0gc00493f

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Continuous-Flow Syntheses of Heterocycles

Glasnov, T.N.; Kappe, C.O.; Continuous-Flow Syntheses of Heterocycles; J. Heterocyclic Chem.; 2011; 48; 11-30

DOI: 10.1002/jhet.568

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Unusual behavior in the reactivity of 5-substituted- 1H-tetrazoles in a resistively heated microreactor

Gutmann, B.; Glasnov, T.N.; Razzaq, T.; Goessler, W.; Roberge, D.M. and Kappe, C.O.; Unusual behavior in the reactivity of 5-substituted- 1H-tetrazoles in a resistively heated microreactor; Beilstein J. Org. Chem.; 2011; 7, 503-517

DOI: 10.3762/bjoc.7.59

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Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki-Miyaura cross-couplings

Spencer, J.; Baltus, C.B.; Press, N.J.; Harrington, R.W.; Clegg, W.; Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki-Miyaura cross-couplings; Tetrahedron Letters; 2011; 52 (31); 3963-3968

DOI: 10.1016/j.tetlet.2011.05.025

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Flow chemistry approach for partial deuteration of alkynes: synthesis of deuterated taxol side chain

Chandrasekhar, S.; Vijaykumar, B.V.D.; Mahesh Chandra, B.; Raji Reddy, Ch.; Naresh, P.; Flow chemistry approach for partial deuteration of alkynes: synthesis of deuterated taxol side chain; Tetrahedron Letters; 2011; 52; 3865-3867

DOI: 10.1016/j.tetlet.2011.05.042

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A Scalable Two-Step Continuous Flow Synthesis of Nabumetone and Related 4-Aryl-2-butanones

Viviano, M.; Glasnov, T.N.; Reichard, B.; Tekautz, B.; Kappe, C.O.; A Scalable Two-Step Continuous Flow Synthesis of Nabumetone and Related 4-Aryl-2-butanones; Org. Process Res. Dev.; 2011; 15; 858-870

DOI: 10.1021/op2001047

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Elucidation of a Structural Basis for the inhibitor-Driven, p62 (SQSTM1)-Dependent Intracellular Redistribution

Day, J.P.; Lindsay, B.; Riddel, T.; Jiang, Z.; Allock, R.W.; Abraham, A.; Sookup, S.; Christian, F.; Bogum, J.; Martin, E.K.; Rae, R.L.; Anthony, D.; Rosair, G.M.; Houslay, D.M.; Huston, E.; Baillie, G.S.; Klussmann, E.; Houslay, M.D.; Adams, D.R.; Elucidation of a Structural Basis for the inhibitor-Driven, p62 (SQSTM1)-Dependent Intracellular Redistribution of cAMP Phosphodiesterase-4A4 (PDE4A4); J. Med. Chem.; 2011; 54(9); 3331-3347

DOI: 10.1021/jm200070e

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Dissection of Complex Molecular Recognition Interfaces

Hunter, C.A.; Misuraca, M.C.; Turega, S.M.; Dissection of Complex Molecular Recognition Interfaces; J. Am. Chem. Soc.; 2011; 133(3); 582-594

DOI: 10.1021/ja1084783

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Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods

Baumann, M.; Baxendale, I.R.; Kuratli, C.; Ley, S.V.; Martin, R.E.; Schneider, J.; Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods; ACS Comb. Sci.; 2011; 13(4); 405-413

DOI: 10.1021/co2000357

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Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles

Tarleton, M.; Gilbert, J; Robertson, J. M.; McCluskey, A.; Sakoff, A. J; Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound; MedChemComm; 2011; 2; 31-37

DOI: 10.1039/c0md00147c

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3-Substituted xanthines as promising candidates for quadruplex formation: computational, synthetic and analytical studies

Szolomájer, J.; Paragi, G.; Batta, Gy.; Guerra, F. C.; Bickelhaupt, M. F.; Kele, Z.; Pádár, P.; Kupihár, Z.; Kovács, L.; 3-Substituted xanthines as promising candidates for quadruplex formation: computational, synthetic and analytical studies; New Journal of Chemistry; 2011; 35; 476-482

DOI: 10.1039/c0nj00612b

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Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

Spencer, J.; Rathnam, P. R.; Harvey, L. A.; Clements, J. C.; Clark, L. R.; Barrett, P. M.; Wong, E. P.; Male, L.; Coles, J. S.; Mackay, P. S.; Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity; Bioorganic & Medicinal Chemistry; 2011; 19; 1802-1815

DOI: 10.1016/j.bmc.2011.01.010

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A flow chemistry route to 2-phenyl-3-(1H-pyrrol-2-yl)propan-1-amines

Tarleton, M.; McCluskey, A.; A flow chemistry route to 2-phenyl-3-(1H-pyrrol-2-yl)propan-1-amines; Tetrahedron Letters; 2011; 52; 1583-1586

DOI: 10.1016/j.tetlet.2011.01.096

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Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry

Ekholm, S. F.; Mándity, M. I.; Fülöp, F.; Leino, R.; Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry; Tetrahedron Letters; 2011; 52; 1839-1841

DOI: 10.1016/j.tetlet.2010.12.109

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Building β-Peptide H10/12 Foldamer Helices with Six-Membered Cyclic Side-Chains: Fine-Tuning of Folding and Self-Assembly

Mándity, M. I.; Fülöp, L.; Vass, E.; Tóth; K. G.; Martinek, A. T.; Fülöp, F.; Building β-Peptide H10/12 Foldamer Helices with Six-Membered Cyclic Side-Chains: Fine-Tuning of Folding and Self-Assembly, Organic Letters; 2010; 12 (23); 5584-5587

DOI: 10.1021/ol102494m

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Heterogeneous Catalytic Hydrogenation Reactions in Continuous-Flow Reactors

Irfan, M.; Glasnov, N. T.; Kappe, O. C.; Heterogeneous Catalytic Hydrogenation Reactions in Continuous-Flow Reactors; ChemSusChem; 2011;, 12 (3); 300-316

DOI: 10.1002/cssc.201000354

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Continuous flow ozonolysis in a laboratory scale reactor

Irfan, M.; Glasnov, N. T.; Kappe, O. C.; Continuous flow ozonolysis in a laboratory scale reactor; Organic Letters; 2011; 13(5); 984-987

DOI: 10.1021/ol102984h

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Reductive amination of ketones: novel one-step transfer hydrogenations in batch and continuous-flow mode

Falus, P.; Boros, Z.; Hornyánszky, G.; Nagy, J.; Darvas, F.; Ürge, L.; Poppe, L.; Reductive amination of ketones: novel one-step transfer hydrogenations in batch and continuous-flow mode; Tetrahedron Letters; 2011; 52; 1310-1312

DOI: 10.1016/j.tetlet.2011.01.062

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The synthesis of azabicyclic heterocycles

The synthesis of azabicyclic heterocycles; Darout, E.; Basak, A.; Tetrahedron Letters; 2010; 51; 2998-3001

DOI: 10.1016/j.tetlet.2010.03.123

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Synthesis of functionalized 3-hydroxypiperidines

Wijdeven, M.A.; van Delft, F. L.; Rutjes, F. P. J. T.; Synthesis of functionalized 3-hydroxypiperidines; Tetrahedron; 2010; 66; 5623-5636

DOI: 10.1016/j.tet.2010.05.089

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Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity

Borcard, F.; Baud, M.; Bello, C.; Dal Bello, G.; Grossi, F.; Pronzato, P.; Cea, M.; Nencioni, A.; Vogel, P.; Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity; Bioorg. Med. Chem. Lett.; 2010; 20; 5353-5356

DOI: 10.1016/j.bmcl.2009.09.019

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Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2

Whelligan, D. K.; Solanki, S.; Taylor, D.; Thomson, D. W.; Cheung, K. J.; Boxall, K.; Mas-Droux, C.; Barillari, C.; Burns, S.; Grummitt, C. G.; Collins, I.; van Montfort, E. L. M.; Aherne, G. W.; Bayliss, R.; Hoelder, S.; Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization, J. Med. Chem.; 2010; 53; 7682-7698

DOI: 10.1021/jm1008727

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Novel Spirotetracyclic Zwitterionic Dual H1/5-HT2A Receptor Antagonists for the Treatment of Sleep Disorders

Gianotti, M.; Botta, M.; Brough, S.; Carletti, R.; Castiglioni, E.; Corti, C.; Dal-Cin, M.; Fratte, S. D.; Korajec, D.; Lovric, M.; Merlo, G.; Mesic, M.; Pavone, F.; Piccoli, L.; Rast, S.; Roscic, M.; Sava, A.; Smehil, M.; Stasi, L.; Togninelli, A.; Wigglesworth, M. J.; Novel Spirotetracyclic Zwitterionic Dual H1/5-HT2A Receptor Antagonists for the Treatment of Sleep Disorders; J. Med. Chem.; 2010; 53; 7778-7795

DOI: 10.1021/jm100856p

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Synthesis of a tetrasaccharide related to the triterpenoid saponin Bellisoside isolated from Bellis perennis (compositae)

Mandal, S.; Sharma, N.; Mukhopadhyay, B.; Synthesis of a tetrasaccharide related to the triterpenoid saponin Bellisoside isolated from Bellis perennis (compositae); Tetrahedron: Asymmetry; 2010; 21; 2172-2176

DOI: 10.1016/j.tetasy.2010.06.032

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Reversal of the ee in enantioselective hydrogenation of activated ketones in continuous-flow fixed-bed reactor system

Cserenyi, Sz.; Szollosi, Gy.; Szori, K.; Fulop, F.; Bartok, M.; Reversal of the ee in enantioselective hydrogenation of activated ketones in continuous-flow fixed-bed reactor system; Catalysis Communication; 2010; 12; 14-19

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Straightforward hetero Diels-Alder reactions of nitroso dienophiles by microreactor technology

Monbaliu, J. M. R.; Cukalovic, A.; Marchand-Brynaert, J.; Stevens, C. V.; Straightforward hetero Diels-Alder reactions of nitroso dienophiles by microreactor technology; Tetrahedron Letters; 2010; 51; 5830-58

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Lipase-catalyzed kinetic resolution of 2-methylene-substituted cycloalkanols in batch and continuous-flow modes

Tomin, A.; Hornyánszky, G.; Kupai, K.; Dorko, Zs.; Urge, L.; Darvas, F.; Poppe, L.; Lipase-catalyzed kinetic resolution of 2-methylene-substituted cycloalkanols in batch and continuous-flow modes; Process Biochemistry; 2010; 45; 859-865

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A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin

Brasholz, M.; Macdonald, J. M.; Saubern, S.; Ryan, J. H.; Holmes, A.B.; A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin; Chem. Eur. J., 2010; 16 (37); 11471-11480

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The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist

Baur, F.; Beattie, D.; Beer, D.; Bentley, D.; Bradley, M.; Bruce, I.; Charlton, S. J.; Cuenoud, B.; Ernst, R.; Fairhurst, R. A.; Faller, B.; Farr, D.; Keller, T.; Fozard, J. R.; Fullerton, J.; Garman, S.; Hatto, J.; Hayden, C.; He, H.; Howes, C.; Janus, D.; Jiang, Z.; Lewis, C.; Loeuillet-Ritzler, F.; Moser, H.; Reilly, J.; Steward, A.; Sykes, D.; Tedaldi, L.; Trifilieff, A.; Tweed, M.; Watson, S.; Wissler, E.; Wyss, D.; The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist; J. Med. Chem.; 2010; 53; 3675-3684

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Origin of the rate enhancement and enantiodifferentiation in the heterogeneous enantioselective hydrogenation

SzÅ‘llÅ‘si, Gy.; Cserényi, Sz.; Bucsi, I.; Bartók, T.; Fülöp, F.; Bartók, M.; Origin of the rate enhancement and enantiodifferentiation in the heterogeneous enantioselective hydrogenation of 2,2,2-trifluoroacetophenone over Pt/alumina studied in continuous-flow fixed-bed reactor system, Applied Catalysis A: General; 2010; 382; 263-271

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De Novo Design of a Picomolar Nonbasic 5-HT1B Receptor Antagonist

Nugiel, D.A.; Krumrine, J.R.; Hill, D.C.; Damewood, J.R.; Bernstein, P.R.; Sobotka-Briner, C.D.; Liu, J.W.; Zacco, A.; Pierson, M.E.; De Novo Design of a Picomolar Nonbasic 5-HT1B Receptor Antagonist; J. Med. Chem.; 2010; 53; 1876-1880

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Synthesis of Unique Scaffolds via Diels-Alder Cycloadditions of Tetrasubstituated Cyclohexadienes

Jones, A. L.; Snyder, J.K.; Synthesis of Unique Scaffolds via Diels-Alder Cycloadditions of Tetrasubstituated Cyclohexadienes; Organic Letters, 2010; 12 (7); 1592-1595

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A Flow Process Using Microreactors for the Preparation of a Quinolone Derivate as a Potent 5HT1B Antagonist;

Qian, Z.; Baxendale, I.R.; Ley, S.V.; A Flow Process Using Microreactors for the Preparation of a Quinolone Derivate as a Potent 5HT1B Antagonist; Synlett; 2010; 4; 505-508

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Continuous Flow Organic Synthesis under High-Temperature/Pressure Conditions

Razzaq, T., Kappe, O.C.; Continuous Flow Organic Synthesis under High-Temperature/Pressure Conditions; Chem. Asian J.; 2010; 5 (6); 1274-1289

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Mechanistic Insights into Copper(I)-Catalyzed Azide-Alkyne Cycloadditions using Continuous Flow Conditions

Fuchs, M.; Goessler, W.; Pilger, C.; Kappe, O.C.; Mechanistic Insights into Copper(I)-Catalyzed Azide-Alkyne Cycloadditions using Continuous Flow Conditions; Adv. Synth. Catal.; 2010; 352; 323-328

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ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

Carter, C. F.; Lange, H.; Ley, S.V.; Baxendale, I. R.; Wittkamp, B.; Goode, J. G.; Gaunt, N. L.; ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing; Org. Process Res. Dev.; 2010; 14; 393-404

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Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes

Damm, M.; Glasnov, T.N.; Kappe, O.C.; Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes; Org. Process Res. Dev.; 2010; 14; 215-224

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A Multistep Continuous-Flow System for Rapid On-Demand Synthesis of Receptor Ligands

Petersen, T.P.; Ritzen, A.; Ulven, T.; A Multistep Continuous-Flow System for Rapid On-Demand Synthesis of Receptor Ligands; Organic Letters; 2009; 11(22); 5134-5137

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Synthesis of Bivalent Lactosides Based on Terephthalamide, N,N’-Diglucosylterephthalamide, and Glycophane Scaffolds

Leyden, R.; Velasco-Torrijos, T.; Andre, S.; Gouin, S.; Gabius, H.; Murphy, P.V.; Synthesis of Bivalent Lactosides Based on Terephthalamide, N,N’-Diglucosylterephthalamide, and Glycophane Scaffolds and Assessment of Their Inhibitory Capacity on Medically Relevant Lectins, J. Org. Chem.; 2009; 74; 9010-9026

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An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process

An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process, Sedelmeier, J., Ley, S.V., Baxendale, I. R.; Green Chemistry, 2009; 11; 683-685

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Accessing Novel Process Windows in a High-Temperature/Pressure Capillary Flow Reactor

Razzaq, T., Glasnov, T. N., Kappe, O. C.; Accessing Novel Process Windows in a High-Temperature/Pressure Capillary Flow Reactor; Chem. Eng. Technol.; 2009; 32(11); 1-6

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Recycling the Waste: The Development of a Catalytic Wittig Reaction

O’Brien, C.J.; Tellez, J.L.; Nixon, Z. S.; Kang, L.J.; Carter, A. L.; Kunkel, S. R.; Przeworski, K.C.; Chass, G. A.; Recycling the Waste: The Development of a Catalytic Wittig Reaction; Angew. Chem. Int. Ed.; 2009; 48; 1-5

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Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists

Cho, K.; Ando, M.; Kobayashi, K.; Miyazoe, H.; Tsujino, T.; Ito, S.; Suzuki, T.; Tanaka, T.; Tokita, S.; Sato, N.; Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists; Bioorganic & Medicinal Chemistry Letters; 2009; 19(16); 4781-4785

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Rearrangement of N-alkyl 1,2-amino alcohols. Synthesis of (S)-toliprolol and (S)-propanolol

Duthion, B.; Metro, T.; Padro, D., G.; Cossy, J.; Rearrangement of N-alkyl 1,2-amino alcohols. Synthesis of (S)-toliprolol and (S)-propanolol; Tetrahedron; 2009; 65(33); 6696-6709

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High pressure, high temperature reactions in continuous flow

Darvas, F.; Dormán, Gy.; Lengyel, L.; Kovács, I.; Jones, R.; Ürge, L.; High pressure, high temperature reactions in continuous flow: Merging discovery and process chemistry; Chemistry Today; 2009;, 27 (3); 40-43

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A simple, efficient, and selective deuteration via a flow chemistry approach

Mándity, I.M.; Martinek, T.A.; Darvas, F.; Fülöp, F.; A simple, efficient, and selective deuteration via a flow chemistry approach; Tetrahedron Letters; 2009; 50; 4372-4374

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New data in the enantioselective hydrogenation of ethyl pyruvate on Pt-cinchona chiral catalyst

Szollosi, Gy.; Cserenyi, Sz.; Balazsik, K.; Fulop, F.; Bartok, M.; New data in the enantioselective hydrogenation of ethyl pyruvate on Pt-cinchona chiral catalyst using continuous-flow fixed-bed reactor system: The origin of rate enhancement; Journal of Molecular Catalysis A: Chemical; 2009; 305; 155-160

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Pyrido[2,3-d]pyrimidin-5-ones:A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors

Huang, H.; Hutta, D.A.; Rinker, J.M.; Hu, H.; Parsons, W.H.; Schubert, C.; DesJarlais, R.L.; Crysler, C.S.; Chaikin, M.A.; Donatelli, R.P.; Chen, Y.; Cheng, D.; Zhou, Z.; Yurkow, E.; Manthey, C.L.; Player, M.R.; Pyrido[2,3-d]pyrimidin-5-ones:A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors; J.Med.Chem.; 2009; 52(4); 1081-1099

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Double carbonylation of iodobenzene in a microfluidics-based high throughput flow reactor

Balogh, J.; Kuik, Á.; Ürge, L.; Darvas, F.; Bakos, J.; Skoda-Földes, R.; Double carbonylation of iodobenzene in a microfluidics-based high throughput flow reactor; Journal of Molecular Catalysis A: Chemical; 2009; 302; 76-79

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Construction of a Bicyclic β-Benzyloxi and β-Hydroxy Amide Library through a Multicomponent Cyclization

Zhang, L., Xiao, Q., Ma, C., Xie, X., Floreancig, P. E.; Construction of a Bicyclic β-Benzyloxi and β-Hydroxy Amide Library through a Multicomponent Cyclization Reaction; J. Comb. Chem.; 2009; 11(4); 640-644

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Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor

Dong, S.; Hamel, E.; Bai, R.; Covell, D.G.; Beutler, J.A.; Porco, J.A.; Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor; Angew. Chem. Int. Ed.; 2009; 48 (8); 1494-1497

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Continuous Flow Hydrogenation of Functionalized Pyridines

Irfan, M.; Petricci, E.; Glasnov, T. N.; Taddei, M.; Kappe, O.C.; Continuous Flow Hydrogenation of Functionalized Pyridines; Eur. J. Org. Chem.; 2009; 9; 1327-1334

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Synthesis of Symmetric Dinitro-Functionalised Trögerۥs Base Analogues

Bhuiyan, M. D. H.; Mahon, A.B.; Jensen, P.; Clegg, J.K.; Try, A.C.; Synthesis of Symmetric Dinitro-Functionalized Tröger's Base Analogues; Eur. J. Org. Chem.; 2009; 5; 687-698

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Continuous-Flow Microreactor Chemistry under High-Temperature/Pressure Conditions

Razzaq, T.; Glasnov, T.N.; Kappe, O. C.; Continuous-Flow Microreactor Chemistry under High-Temperature/Pressure Conditions; Eur. J. Org. Chem.; 2009; 9; 1321-1325

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Heterogeneous Versus Homogeneous Palladium Catalysts for Ligandless Mizoroki-Heck Reactions

Glasnov, T.N.; Findenig, S.; Kappe, O.C.; Heterogeneous Versus Homogeneous Palladium Catalysts for Ligandless Mizoroki-Heck Reactions: A Comparison of Batch/Microwave and Continuous-Flow Processing; Chem. Eur. J.; 2009; 15; 1001-1010

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New Data on the Orito Reaction: Effect of Substrate on Nonlinear Phenomenon

Balazsik, K., Cserenyi,  Sz., Szollosi, Gy., Fulop, F., Bartok, M.; New Data on the Orito Reaction: Effect of Substrate on Nonlinear Phenomenon; Catal. Lett.; 2008; 125; 401-407

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High-Efficiency Aminocarbonylation by Introducing CO to a Pressurized Continuous Flow Reactor

Csajagi, Cs.; Borcsek, B., Niesz, K.; Kovacs, I.; Szekelyhidi, Zs.; Bajko, Z.; Ugre, L.; Darvas, F.; High Efficiency Aminocarbonylation by Introducing CO to a Pressurized Continuous Flow Reactor; Org. Lett.; 2008; 10 (8); 1589 - 1592

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Electrophile-Induced Dearomatizing Spirocyclization of N-Arylisonicotinamides: A Route to Spirocyclic Piperidines

Arnott, G.; Brice, H.; Clayden, J.; Blaney, E.; Electrophile-Induced Dearomatizing Spirocyclization of N-Arylisonicotinamides: A Route to Spirocyclic Piperidines; Organic Letters; 2008; 10(14); 3089-3092

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Synthesis of Nanostructures on a Microfluidic-based Flow Device

Niesz, K.; Wootsch, A.; Otvos, Zs.; Darvas, F., Synthesis of Nanostructures on a Microfluidic-based Flow Device; MST News; 2008; 3(8); 30-31

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Flow reactors for drug discovery Flow for reaction optimization, library synthesis, and scale up

Jones, R. V.; Csajagi, Cs.; Szekelyhidi, Zs.; Kovacs, I.; Borcsek, B.; Urge, L.; Darvas, F.; Flow reactors for drug discovery Flow for reaction optimization, library synthesis, and scale up; Chemistry Today; 2008; 26(3); 10-13

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Enantiomer selective acylation of racemic alcohols by lipases in continuous-flow bioreactors

Csajagi, Cs., Szatzker, G., Toke, E.R., Urge, L., Darvas, F., Poppe, L.; Enantiomer selective acylation of racemic alcohols by lipases in continuous-flow bioreactors; Tetrahedron: Asymmetry; 2008; 19(2); 237-246

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Nanoparticle synthesis completed with in situ catalyst preparation

Niesz, K., Hornyak, I., Borcsek, B., Darvas, F., Nanoparticle synthesis completed with in situ catalyst preparation performed on a high-pressure high-temperature continuous flow reactor; Microfluidics and Nanofluidics; 2008; 1613-4982

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Synthesis of sugar-lactams from azides of glucuronic acid

Loukou, C.; Tosin, M.; Müller-Bunz, H.; Murphy, P. V.; Synthesis of sugar-lactams from azides of glucuronic acid; Carbohydrate Research; 2007; 342 (12-13); 1953-1959

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Automated Technology for Performing Flow-Chemistry at Elevated Temperature and Pressure

Kovacs, I., Jones, R., Niesz, K., Csajagi, Cs.,  Borcsek, B., Darvas, F., Urge, L.; Automated Technology for Performing Flow-Chemistry at Elevated Temperature and Pressure; Journal of the Association for Laboratory Automation; 2007; 12 (5); 284-290

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Enantioselective hydrogenation of α,ß-unsaturated carboxylic acids in fixed-bed reactor

Herman, B., Szollosi, Gy., Fulop F., Bartok, M.; Enantioselective hydrogenation of α,ß-unsaturated carboxylic acids in fixed-bed reactor; Applied Catalysis A: General; 2007; 331; 39-43

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Optimisation of Conditions for O-benzyl and N-Benzyloxycarbonyl Protecting Group removal

Knudsen, K.R.; Holde, J.; Ley, S.V.; Ladlow, M.; Optimisation of Conditions for O-benzyl and N-Benzyloxycarbonyl Protecting Group removal using an Automated Flow Hydrogenator; Adv. Synth. Catal.; 2007; 349; 535-538

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Mesoscale Flow Chemistry: A Plug-Flow Approach to reaction Optimisation

Wheeler, R.C.; Benali, O.; Deal, M.; Farrant, E.; MacDonald, S.J.F.; Warrington, B.H.; Mesoscale Flow Chemistry: A Plug-Flow Approach to reaction Optimisation; Org. Process Res. Dev.; 2007; 11; 704-710

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Selective catalytic hydrogenations in a microfluidics-based high-throughput flow reactor

Horvath, H., H., Papp, G., Csajagi, Cs., Joó, F.; Selective catalytic hydrogenations in a microfluidics-based high-throughput flow reactor on ion-exchange supported transition metal complexes: A modular approach to the heterogenization of soluble complex catalyst; Cat. Comm., 2007; 8; 442-446

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Asymmetric Mannich Reaction of Dicarbonyl Compounds with α-Amido Sulfones Catalyzed by Cinchona Alkaloids

Lou, S., Dai, P., Schaus, S.E., Asymmetric Mannich Reaction of Dicarbonyl Compounds with α-Amido Sulfones Catalyzed by Cinchona Alkaloids and Synthesis of Chiral Dihydropyrimidones; J. Org. Chem; 2007; 72; 9998-10008

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Synthesis of macroline-saccharide hybrids by ring-closing metathesis of precursors derived from glycitols and benzoic acids

Matos, M and Murphy, P., V.; Synthesis of macroline-saccharide hybrids by ring-closing metathesis of precursors derived from glycitols and benzoic acids; J. Org. Chem.; 2007; 72; 1803-1806

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Scaling up and validation of hydrogenation reactions using a continuous-flow microfluidics-based reactor, H-Cube™

Spadoni, C; Jones, R.; Urge, L.; Darvas, F.; Scaling up and validation of hydrogenation reactions using a continuous-flow microfluidics-based reactor, H-Cube®; Chem. Today; February/March 2006; 38-41

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Continuous-flow high pressure hydrogenation reactor for optimization and high-throughput synthesis

Jones, R., Godorhazy, L., Varga, N., Szalay, D., Gerencser, J.; Dorman, Gy.; Urge, L., and Darvas, F.; Continuous-flow high pressure hydrogenation reactor for optimization and high-throughput synthesis; J. Comb. Chem.; 2006; 8(1); 110-116

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Continuous enantioselective hydrogenation of activated ketoneson a pt-cd chiral catalyst: use of H-cube reactor system

Szollosi, Gy., Herman, B., Fulop, F., and Bartok, M.; Continuous enantioselective hydrogenation of activated ketones on a pt-cd chiral catalyst: use of H-cube reactor system; Reaction Kinetics and Catalysis Letters; 2006; 88(2); 391-398

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Practical Synthesis of (S)-Pyrrolidin – 2-yl-1H-tetrazole, Incorporating Efficient Protecting Group Removal

Franckevicius, V, Knudsen, K.R., Ladlow, M., Longbottom, D.A.  and Ley, S.V.; Practical Synthesis of (S)-Pyrrolidin-2-yl-1H-tetrazole, Incorporating Efficient Protecting Group Removal by Flow-reactor Hydrogenolysis; Synlett; 2006; 6; 889-892

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Combining Enabling Techniques in Organic Synthesis: Continuous Flow Process with Heterogenized Catalysts

Kirschning, A. Solodenko, W. Mennecke, K.; Combining Enabling Techniques in Organic Synthesis: Continuous Flow Process with Heterogenized Catalysts; Chem. Eur. J.; 2006; 12(23); 5972-5990

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Heterogeneous hydrogenation reactions using a continuous flow high pressure device

Desai, B. and Kappe, O.; Heterogeneous hydrogenation reactions using a continuous flow high pressure device; Journal of Combinatorial Chemistry; 2005; 7(5); 641-643

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How to use continuous flow reactors for the efficient reduction of imines to amines

Saaby, S., Knudsen, K.R., Ladlow, M., Ley, S.V.; The use of a continuous-flow reactor employing a mixed hydrogen-liquid flow steam for the efficient reduction of imines to amines; Chemical Communication; 2005; 23; 2909-11

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The recent advancement of hydrogenation technology and their implications for drug discovery research

Spadoni, S., Jones, R., Urge, L. and Darvas, F.; The recent advancement of hydrogenation technology and their implications for drug discovery research; Chem. Today, January/February 2005; 36-39

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A novel method for high-throughput reduction of compounds through automated sequential injection

Jones, R., Godorhazy, L., Szalay, D., Gerencser, J., Dorman, Gy., Urge, L., Darvas, F.; A novel method for high-throughput reduction of compounds through automated sequential injection into a continuous-flow microfluidic reactor; QSAR Comb. Sci.; 2005; 24(6); 722-727

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A Continuous-Flow Approach to Palladium-Catalyzed Alkoxycarbonylation Reactions

Kelly, C.B.; Lee, C.(X.); Mercadante, M.A.; Leadbeater N.E.; A Continuous-Flow Approach to Palladium-Catalyzed Alkoxycarbonylation Reactions; Org. Process Res. Dev.; 2011; 15; 717-720

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Continuous flow multi-step organic synthesis

Webb, D.; Jamison, T. F.; Continuous flow multi-step organic synthesis; Chemical Science; 2010; 6; 675-680

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Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane to Effect Gas-Liquid Contact

O’Brien, M.; Baxendale, I. R.; Ley, S. V.; Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane to Effect Gas-Liquid Contact; Organic Letters; 2010; 12 (7); 1596-1598

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Synthesis of a novel C2/C2’-aryl-substituated pyrrolo[2,1-c][1,4]benzodiazepine dimer produg

Howard, P. W., Chen, Z., Gregson, S. J., Masterson, L. A., Tiberghien, A. C., Cooper, N., Fang, M., Coffils, M. J., Klee, S., Hartley, J. A., Thurston, D.E.; Synthesis of a novel C2/C2’-aryl-substituated pyrrolo[2,1-c][1,4]benzodiazepine dimer produg with improved water solubility and reduced DNA reaction rate; Bioorg. Med. Chem. Lett.; 2009; 19(22); 6463-6466

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Automation Highlights from the Literature

Thurow, K.; Weinmann, H.; Automation Highlights from Literature; Journal of the Association for Laboratory Automation; 2006; 11 (4); 167-171

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Synthesis of tetrazole analogues of amino acids using Fmoc chemistry

Sureshbabu, V.V.; Venkataramanarao, R.; Naik, S.A.; Chennakirshnareddy, G.; Synthesis of tetrazole analogues of amino acids using Fmoc chemistry: isolation of amino free tetrazoles and their incorporation into peptides; Tetrahedron Letters; 2007; 48(39); 7038-7041

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High pressure in organic chemistry on the way to miniaturization

Benito-Lopez, F.; Egberink, E.J.M.; Reinhoudt, D.N.; Verboom, W.; High pressure in organic chemistry on the way to miniaturization; Tetrahedron; 2008; 64(43); 10023-10040

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The Changing Face of Organic Synthesis

Ley, S.V.; Baxendale, I.R.; The Changing Face of Organic Synthesis; Chimia; 2008; 62 (3); 162-168

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Boosting the flow in pharmaÛ¥s pipelines

Crow, J. M., Boosting the flow in pharma's pipelines; Chemistry World; 2008; 5 (6)

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Tools for efficient high-throughput synthesis

Chighine, A.; Sechi, G., Bradley, M.; Tools for efficient high-throughput synthesis; Drug Discovery Today; 2007; 12 (11/12); 459-464

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Some Items of Interest to Process R&D Chemists and Engineers

McLaughlin, M.; Rubio, S. G.; Tilstam, U.; Antunes, O. A. C.; Laird, T.; Zlota, A.; Some Items of Interest to Process R&D Chemists and Engineers; Organic Process Research & Development; 2007; 11; 652-662

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The Future of Organic Synthesis

Kündig, P.; The Future of Organic Synthesis; Science; 2006; 314; 430-431

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Automated Medicinal Chemistry

Koppitz, M., Eis, K., Automated Medicinal Chemistry; Drug Discovery Today; 2006; 11(11/12); 561-568

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A Flow Process for the Multi-Step Synthesis of the Alkaloid Natural Product Oxomaritidine

Baxendale, I.R., Deeley, J., Griffiths-Jones, C.M.,  Ley, S.V., Saaby, S. and Tranmer, G.; A Flow Process for the Multi-Step Synthesis of the Alkaloid Natural Product Oxomaritidine: A New Paradigm for Molecular Assembly; J. Chem. Soc., Chem. Commun.; 2006; 2566-2568.

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A flow reactor process for the synthesis of peptides utilizing immobilized reagents

Baxendale, I.R.; Ley, S.V.; Smith, C.D.; Tranmer, G.K.; A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols; Chem. Commun.; 2006; 4835-4837

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Multistep continuous reaction shows the power of automated flow synthesis

Ritter, S., Natural product synthesis on the fly. Multistep continuous reaction shows the power of automated flow synthesis; Chemical&Engineering News; 2006; 84(10); 17

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Microfluidics in commercial applications; an industry perspective

Microfluidics in commercial applications; an industry  perspective; Lab Chip; 2006; 6; 1118-1121

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Recent Advances in Asymmetric Catalysis in Flow

Zhao, D.; Ding, K.; Recent Advances in Asymmetric Catalysis in Flow; ACS Catal.; 2013; 3(5), 928-944

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De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments

Urich, R.; Wishart, G.; Kiczun, M.; Richters, A.; Tidten-Luksch, N.; Rauh, D.; Sherborne, B.; Wyatt, P. G.; Brenk, R.; De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments; ACS Chem. Biol.; 2013; 8 (5); 1044-1052

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Disubstituted 1-Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design

Bryan, M. C.; Hein, C. D.; Gao, H.; Xia, X.; Eastwood, H.; Bruenner, B. A.; Louie, S. W.; Doherty, E. M.;Disubstituted 1-Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design; ACS Comb. Sci.; 2013; 15 (9); 503-511

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Toward a Continuous-Flow Synthesis of Boscalid

Glasnov, T.N.; Kappe; C.O.; Toward a Continuous-Flow Synthesis of Boscalid; Adv. Synth. Catal.; 2010; 352; 3089-3097

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Characterization of Dispersion Effects on Reaction Optimization and Scale-Up for a Packed Bed Flow Hydrogenation Reactor

Eschelbach, J. W.; Wernick, D.; Bryan, M. C.; Doherty, E. M.; Characterization of Dispersion Effects on Reaction Optimization and Scale-Up for a Packed Bed Flow Hydrogenation Reactor; Aust. J. Chem. 2013, 66, 165-171

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Efficient continuous-flow synthesis of novel 1,2,3- triazole-substituted β-aminocyclohexanecarboxylic acid derivatives

Ötvös, S. B.; Georgiádes, Á.; Mándity, I. M.; Kiss, L.; Fülöp, F.; Efficient continuous-flow synthesis of novel 1,2,3- triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production; Beilstein J. Org. Chem.; 2013; 9; 1508-1516

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Synthesis and Structure−Activity Relationship (SAR) of 2‑Methyl-4-oxo-3-oxetanylcarbamic Acid Esters

Ponzano, S.; Bertozzi, F.; Mengatto, L.; Dionisi, M.; Armirotti, A.; Romeo, E.; Berteotti, A.; Fiorelli, C.; Tarozzo, G.; Reggiani, A.; Duranti, A.; Tarzia, G.; Mor, M.; Cavalli, A.; Piomelli, D.; Bandiera, T.; Synthesis and Structure-Activity Relationship (SAR) of 2-Methyl-4-oxo-3-oxetanylcarbamic Acid Esters, a Class of Potent N-Acylethanolamine Acid Amidase (NAAA) Inhibitors; J. Med. Chem., 2013;  56 (17); 6917-6934

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Design and Synthesis of Diazatricyclodecane Agonists of the G‑Protein-Coupled Receptor 119

Darout, E.; Robinson, R. P.; McClure, K. F.; Corbett, M.; Li, B.; Shavnya, A.; Andrews, M. P.; Jones, C. S.; Li, Q.; Minich, L. M.; Mascitti, V.; Guimaraes, C. R. W.; Munchhof, M. J.; Bahnck, K. B.; Cai, C.; Price, D. A.; Liras, S.; Bonin, P. D.; Cornelius, P.; Wang, R.; Bagdasarian, V.; Sobota, C. P.; Hornby, S.; Masterson, V. M.; Joseph, R. M.; Kalgutkar, A. S.; Chen, Y.; Design and Synthesis of Diazatricyclodecane Agonist of the G-Protein-Coupled Receptor 119; J. Med. Chem.; 2013; 56; 301-319

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How the mode of Candida antarctica lipase B immobilization affects the continuous-flow kinetic resolution

Boros, Z.; Falus, P.; Markus, M.; Weiser, D.; Olah, M.; Hornyanszky, G.; Nagy, J.; Poppe, L.; How the mode of Candida antarctica lipase B immobilization affects the continuous-flow kinetic resolution of racemic amines at various temperatures; Journal of Molecular Catalysis B: Enzymatic; 2013; 85- 86; 119- 125

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Towards a continuous flow environment for lipase-catalyzed reactions

Itabaiana, I. Jr.; Soter de Mariz e Miranda, L.; de Souza, R. O. M. A.; Towards a continuous flow environment for lipase-catalyzed reactions; Journal of Molecular Catalysis B: Enzymatic; 2013; 85- 86; 1- 9

DOI 10.1016/j.molcatb.2012.08.008

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Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Lawrence, H. R.; Kazi, A.; Luo, Y.; Kendig, R.; Ge, Y., Jain, S.; Daniel, K.; Santiago, D.; Guida, W. C.; Sebti, S. M.; Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors; Bioorg. Med. Chem.; 2010; 18 (15); 5576-5592

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Oxazolomycins: Natural product lead structures for novel antibacterials by click fragment conjugation

Bagwell, C. L.; Moloney, M. G.; Yaqoob, M.; Oxazolomycins: Natural product lead structures for novel antibacterials by click fragment conjugation; Bioorg. Med. Chem. Lett.; 2010; 20; 2090-2094

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2,7-Pyrrolo[2,1-f][1,2,4]triazines as JAK2 inhibitor

Weinberg, L.R.; Albom, M.S.; Angeles, T.S.; Breslin, H.J.; Gingrich, D.E.; Huang, Z.; Lisko, J.G.; Mason, J.L.; Milkiewicz, K.L.; Thieu, T.V.; Underiner, T.L.; Wells, G.J.; Wells-Knecht, K.J.; Dorsey, B.D.; 2,7-Pyrrolo[2,1-f][1,2,4]triazines as JAK2 inhibitors: modification of target structure to minimize reactive metabolite formation; Bioorganic & Medicinal Chemistry Letters; 2011; 21(24); 7325 - 7330

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Synthesis of Staphylococcus aureus type 5 capsular polysaccharide repeating unit

Danieli, E.; Proietti, D.; Brogioni, G.; Romano, M. R.;  Synthesis of Staphylococcus aureus type 5 capsular polysaccharide repeating unit using novel L-FucNAc and D-FucNAc synthons and immunochemical evaluation; Bioorganic & Medicinal Chemistry; 2012; 20; 6403-6415

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Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

Manzoni, L.; Belvisi, L.; Bianchi, A.; Conti, A.; Drago, C.; de Matteo, M.; Ferrante, L.; Mastrangelo, E.; Perego, P.; Potenza, D.; Scolastico, C.; Servida, F.; Timpano, G.; Vasile, F., Rizzo, V.; Seneci, P.; Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis; Bioorganic & Medicinal Chemistry; 2012; 20; 6687-6708

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Development of Second-Generation Indole-Based Dynamin GTPase Inhibitors

Gordon, C. P.; Venn-Brown, B.; Robertson, M. J.; Young, K. A.; Chau, N.; Mariana, A.; Whiting, A.; Chircop, M.; Robinson, P. J.; McCluskey, A.; Development of Second-Generation Indole-Based Dynamin GTPase Inhibitors; J. Med. Chem.; 2013; 56; 46-59

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Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase

Giordanetto, F.; Wĺllberg, A.; Cassel, J.; Ghosal, S.; Kossenjans, M.; Yuan, Z. Q.; Wang, X.; Liang, L.; Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation; Bioorganic & Medicinal Chemistry Letters; 2012; 22; 6665-6670

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Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis

Desai, B.; Dixon, K.; Farrant, E.; Feng, Q.; Gibson, K. R.; van Hoorn, W. P.; Mills, J.; Morgan, T.; Parry, D. M.; Ramjee, M. K.; Selway, C. N.; Tarver, G. J.; Whitlock, G.; Wright, A. G.; Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform; J. Med. Chem.; 2013; 56(7); 3033-3047

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Identification and Characterization of Carprofen as a Multitarget Fatty Acid Amide Hydrolase/Cyclooxygenase Inhibitor

Favia, A. D.; Habrant, D.; Scarpelli, R.; Migliore, M.; Albani, C.; Bertozzi, S. M.; Dionisi, M.; Tarozzo, G.; Piomelli, D.; Cavalli, A.; De Vivo, M.; Identification and Characterization of Carprofen as a Multitarget Fatty Acid Amide Hydrolase/Cyclooxygenase Inhibitor; J. Med. Chem.; 2012; 55, 8807−8826

DOI 10.1021/jm3011146

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Discovery of selective biaryl ethers as PDE10A inhibitors

Rzasa, R. M.; Hu, E.; Rumfelt, S.; Chen, N.; Andrews, K. L.; Chmait, S.; Falsey, J. R.; Zhong, W.; Jones, A. D.; Porter, A.; Louie, S. W.; Zhao, X.; Treanor, J. J. S.; Allen, J. R.; Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux; Bioorganic & Medicinal Chemistry Letters; 2012, 22; 7371-7375

DOI: 10.1016/j.bmcl.2012.10.078

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Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists

Batie, S.; Lee, J. H.; Jama, R. A:; Browder, D. O.; Montano, L. A.; Huynh, C. C.; Marcus, L. M.; Tsosie, D. G.; Mohammed, Z.; Trang, V.; Marshall, P. A.; Jurutka, P. W.; Wagner, C. E.; Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists; Bioorganic & Medicinal Chemistry; 2013; 21; 693-702

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Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2

Andrés, J. I.; Alcázar, J.; Cid, J. M.; De Angelis, M., Iturrino, L.; Langlois, X.; Lavreysen, H.; Trabanco, A. A.; Celen, S.; Bormans, G.; Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging, J. Med. Chem.; 2012; 55; 8685−8699

DOI 10.1021/jm300912k

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Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design

Efremov, I.V.; Vajdos, F. F.; Borzilleri, K. A.; Capetta, S.; Chen, H.; Dorff, P. H.; Dutra, J. K.; Goldstein, S. W.; Mansour, M.; McColl, A.; Noell, S.; Oborski, C. E.; O’Connell, T. N.; O’Sullivan, T. J.; Pandit, J.; Wang, H.; Wei, B.; Withka, J. M.; Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design; Journal of Medicinal Chemistry; 2012; 55(21); 9069-88

DOI 10.1021/jm201715d

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Discovery of 7- Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3- dihydro- 1H- indol-5-yl)- 7H- pyrrolo[2,3-d]…

Axten, J. M.; Medina, J. R.; Feng, Y.; Shu, A.; Romeril, S. P.; Grant, S. W.; Li, W. H. H.; Heerding, D. A.; Minthorn, E.; Mencken, T.; Atkins, C.; Liu, Q.; Rabindran, S.; Kumar, R.; Hong, X.; Goetz, A.; Stanley, T.; Taylor, J. D.; Sigethy, S. D.; Tomberlin, G. H.; Hassell, A. M.; Kahler, K. M.; Shewchuk, L. M.; Gampe, R. T.; Discovery of 7- Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3- dihydro- 1H- indol-5-yl)- 7H- pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK); Journal of Medicinal Chemistry; 2012; 55(16); 7193-7207

DOI 10.1021/jm300713s

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Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors

Zak, M.; Mendonca, R.; Balazs, M.; Barrett, K.; Bergeron, P.; Blair, W. S.; Chang, C.; Deshmukh, G.; DeVoss, J.; Dragovich, P. S.; Eigenbrot, C.; Ghilardi, N.; Gibbons, P.; Gradl, S.; Hamman, C.; Hanan, E.; Harstad, E.; Hewitt, P. R.; Hurley, C. A.; Jin, T.; Johnson, A.; Johnson, T.; Kenny, J. R.; Koehler, M. F. T.; Kohli, P. B.; Kulagowski, J.; Labadie, S.; Liao, J.; Liimatta, M.; Lin, Z.; Lupardus, P. J.; Maxey, R. J.; Murray, J. M.; Pulk, R.; Rodriguez, M.; Savage, S.; Shia, S.; Steffek, M.; Ubhayakar, S.; Ultsch, M.; Van-Abbema, A.; Ward, S.; Xiao, L.; Xiao, Y.; Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2; Journal of Medicinal Chemistry; 2012; 55(13); 6176-93

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Synthesis and Biological Evaluation of an Orally Active Glycosylated Endomorphin-1

Varamini, P.; Mansfeld, F. M.; Blanchfield, J. T.; Wyse, B. D.; Smith, M. T.; Toth, I.; Synthesis and Biological Evaluation of an Orally Active Glycosylated Endomorphin-1; Journal of Medicinal Chemistry; 2012; 55(12); 5859-5867

DOI 10.1021/jm300418d

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Structure-Based Design of Potent and Ligand-Efficient Inhibitors of CTX-M Class A β-Lactamase

Nichols, D. A.; Jaishankar, P.; Larson, W.; Smith, E.; Liu, G.; Beyrouthy, R.; Bonnet, R.; Renslo, A. R.; Chen, Y.; Structure-Based Design of Potent and Ligand-Efficient Inhibitors of CTX-M Class A β-Lactamase; Journal of Medicinal Chemistry; 2012; 55(5); 2163-72

DOI 10.1021/jm2014138

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Discovery and Synthesis of Hydronaphthoquinones as Novel Proteasome Inhibitors

Ge, Y.; Kazi, A.; Marsilio, F.; Luo, Y.; Jain. S.; Brooks, W.; Daniel, K. G.; Guida, W. C.; Sebti, S. M.; Lawrence, H. R.; Discovery and Synthesis of Hydronaphthoquinones as Novel Proteasome Inhibitors; Journal of Medicinal Chemistry; 2012; 55(5); 1978-1998

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Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors

Andrés, J-I,; De Angelis, M.; Alcázar, J.; Iturrino, L.; Langlois, X.; Dedeurwaerdere, S.; Lenaerts, I.; Vanhoof, G.; Celen, S.; Bormans, G.; Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors as Candidates for Positron Emission Tomography Imaging; J. Med. Chem.; 2011; 54; 5820 - 5835

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Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds

Joyard, Y.; Azzouz, R.; Bischoff, L.; Papamicaël, C.; Labar, D.; Bol, A.; Bol, V.; Vera, P.; Grégoire, V.; Levacher, V.; Bohn, P.; Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds; Bioorganic & Medicinal Chemistry; 2013; 21; 3680-3688

DOI: 10.1016/j.bmc.2013.04.029

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Increasing Selectivity of CC Chemokine Receptor 8 Antagonists by Engineering Nondesolvation Related Interactions

Shamovsky, I. et al.; Increasing Selectivity of CC Chemokine Receptor 8 Antagonists by Engineering Nondesolvation Related Interactions with the Intended and Off-Target Binding Sites; J. Med. Chem.; 2009; 52; 7706-7723

DOI 10.1021/jm900713y

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Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide

Giordanetto, F.; Wĺllberg, A.; Knerr, L.; Selmi, N.; Ullah, V.; Thorstensson, F.; Lindelöf, L.; Karlsson, S.; Nikitidis, G.; Llinas, A.; Wang, Q. D.; Lindqvist, A.; Högberg, L.; Lindhardt, E.; Ĺstrand, A.; Duker, G.; Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor; Bioorganic & Medicinal Chemistry Letters2013; 23; 119-124

DOI: 10.1016/j.bmcl.2012.10.140

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Alkyl-Aryl Negishi Cross-Coupling in Flow: Mild, Efficient and Clean Introduction of Functionalized Alkyl Groups

Egle, B.; Muñoz, J. M.; Alonso, N.; De Borggraeve, W. M., Hoz, A.; Díaz-Ortiz, A.; Alcázar1, J.; First Example of Alkyl-Aryl Negishi Cross-Coupling in Flow: Mild, Efficient and Clean Introduction of Functionalized Alkyl Groups; J. Flow Chem.; 2014; 4 (1); 22-25

DOI 10.1556/JFC-D-13-00009

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Important Industrial Procedures Revisited in Flow: Very Efficient Oxidation and N-Alkylation Reactions with High Atom-Economy

Sipos, G.; Gyóllai, V.; Dormán, Gy.; Kocsis, L.; Jones, R. V.; Darvas, F.; Important industrial procedures revisited in flow: Very efficient oxidation and N-alkylation reactions with high atom-economy; Journal of Flow Chemistry; 2013; 3(2); 51-58

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Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507

Scott, D. A.; Dakin, L. A.; Daly, K.; Del Valle, D. J.; Diebold, R. B.; Drew, L.; Ezhuthachan, J.; Gero, T. W.;  Ogoe, C. A.; Omer, C. A.; Redmond, S. P.; Repik, G.; Thakur, K.; Ye, Q.; Zheng, X.; Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507; Bioorganic & Medicinal Chemistry Letters; 2013; 23; 4591-4596

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Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1

Manka , J. T.; Rodriguez , A. L.; Morrison, R. D.; Venable, D. F.; Cho, H. P.; Blobaum, A. L.; Daniels, J. S.; Niswender, C. M.; Conn, P. J.; Lindsley, C. W.; Emmitte, K. A.; Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1; Bioorganic & Medicinal Chemistry Letters; 2013; 23 (18); 5091-5096

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A benchtop continuous flow reactor: A solution to the hazards posed by gas cylinder based hydrogenation

Dormán, Gy.; Kocsis, L.; Jones, R.; Darvas, F.; A benchtop continuous flow reactor: A solution to the hazards posed by gas cylinder based hydrogenation; Journal of Chemical Health and Safety; 2013; 20 (4); 3-8

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Studies of long chain lipids in insects by high temperature gas chromatography

Sutton, P. A.; Wilde, M. J.; Martin, S. J.; Cvacka, J.; Vrkoslav, V.; Rowland, S. J.; Studies of long chain lipids in insects by high temperature gas chromatography and high temperature gas chromatography-mass spectrometry; Journal of Chromatography A; 2013; 1297; 236- 240

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An alternative route for fondaparinux sodium synthesis

Manikowski, A.; Kozioł, A.; Czajkowska-Wojciechowska, E.; An alternative route for fondaparinux sodium synthesis via selective hydrogenations and sulfation of appropriate pentasaccharides; Carbohydrate Research; 2012; 361; 155-161

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Gram scale de novo synthesis of 2,4-diacetamido-2,4,6-trideoxy-D-galactose

Schmölzer, C.; Nowikow, C.; Kählig, H.; Schmid, W.; Gram scale de novo synthesis of 2,4-diacetamido-2,4,6-trideoxy-D-galactose; Carbohydrate Research; 2013; 367; 1-4

DOI: 10.1016/j.carres.2012.11.019

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Visually Following the Hydrogenation of Curcumin to Tetrahydrocurcumin in a Natural Product Experiment

Wagner, C. E.; Marshall, P. A.; Cahill, T. M.; Mohamed, Z.; Visually Following the Hydrogenation of Curcumin to Tetrahydrocurcumin in a Natural Product Experiment That Enhances Student Understanding of NMR Spectroscopy; J. Chem. Educ.; 2013; 90(7); 930-933

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Asymmetric aldol reaction in a continuous-flow reactor catalyzed by a highly reusable heterogeneous peptide

Ötvös, S. B.; Mándity, I. M.; Fülöp, F.; Asymmetric aldol reaction in a continuous-flow reactor catalyzed by a highly reusable heterogeneous peptide; Journal of Catalysis; 2012; 295; 179-185

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A practical and benign synthesis of amines through Pd@mpg-C3N4 catalyzed reduction of nitriles

Li, Y.; Gong, Y.; Xu, X.; Zhang, P.; Li, H.; Wang, Y.; A practical and benign synthesis of amines through Pd@mpg-C3N4 catalyzed reduction of nitriles; Catalysis Communications; 2012; 28; 9-12

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Construction and Validation of an Automated Flow Hydrogenation Instrument for Application in High-Throughput Organic Chemistry

Clapham, B.; Wilson, N.S.; Mischmerhuizen, M.J.; Blanchard, D.P.; Dingle, D.M.; Nemcek, T.A.; Pan, J.Y.; Sauer, D.R., Construction and Validation of an Automated Flow Hydrogenation Instrument for Application in High-Throughput Organic Chemistry; J. Comb. Chem.; 2008; 10; 88-93

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New data to the origin of rate enhancement on the Pt-cinchona catalyzed enantioselective hydrogenation of activated ketones

SzöllÅ‘si, Gy.; Cserényi, Sz.; Fülöp, F.; Bartók, M.; New data to the origin of rate enhancement on the Pt-cinchona catalyzed enantioselective hydrogenation of activated ketones using continuous-flow fixed-bed reactor system; Journal of Catalysis; 2008; 260(2); 245-253

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Ruthenium and Osmium complexes of novel carbohydrate derived salen ligands

Mandal, S.; Mandal, S.; Seth, D. K.; Mukhopadhyay, B.; Gupta, P.; Ruthenium and osmium complexes of novel carbohydrate derived salen ligands: Synthesis, characterization and in situ ligand reduction; Inorganica Chimica Acta; 2013; 398; 83-88

DOI 10.1016/j.ica.2012.12.016

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Novel Evidence on the Role of the Nucleophilic Intermediate Complex in the fiorito-reaction

Szollosi, Gy.; Cserenyi, Sz.; Bartok, M.; Novel Evidence on the Role of the Nucleophilic Intermediate Complex in the fiorito-Reaction: Unexpected Inversion in the Enantioselective Hydrogenation of 2,2,2-Trifluoroacetophenone on Pt-Cinchona Chiral Catalyst Using Continuous-Flow Fixed-Bed Reactor; Catal. Lett.; 2010; 134; 264-269

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Electrochemical Phenylselenoetherification as a Key Step in the Synthesis of (±)-Curcumene Ether

Stevanovié, D.; Pejovié, A.; Damljanovié, I. S.; Vukiéevié, M. D.; Dobrikov, G.; Dimitrov, V.; Denié, M. S.; Radulovié, N. S.; Vukiéevié, R. D.; Electrochemical Phenylselenoetherification as a Key Step in the Synthesis of (±)-Curcumene Ether; Helvetica Chimica Acta; 2013; 96(6); 1103-1110

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Nanocatalysis in continuous flow: supported iron oxide nanoparticles for the heterogeneous aerobic oxidation of benzyl alcohol

Obermayer, D.; Balu, A. M.; Romero, A. A.; Goessler, W.; Luque, R.; Kappe, C. O.; Nanocatalysis in continuous flow: supported iron oxide nanoparticles for the heterogeneous aerobic oxidation of benzyl alcohol; Green Chem.; 2013; 15; 1530-1537

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The role of flow in green chemistry and engineering

Newman, S. G.; Jensen, K. F.; The role of flow in green chemistry and engineering; Green Chem.; 2013; 15; 1456-1472

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A facile, protic ionic liquid route to N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides

Gordon, C. P.; Byrne, N.; McCluskey, A., A facile, protic ionic liquid route to N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides and N-substituted 3-oxoisoindoline-4-carboxylic acids; Green Chem.; 2010; 12; 1000-1006

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Transfer hydrogenation of levulinic acid under hydrothermal conditions catalyzed by sulfate as a temperature-switchable base

Kopetzki, D.; Antonietti, M.; Transfer hydrogenation of levulinic acid under hydrothermal conditions catalyzed by sulfate as a temperature-switchable base; Green Chem.; 2010; 12; 656-660

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Access to Optically Active 3-Aminopiperidines by Ring Expansion of Prolinols: Thermodynamic versus Kinetic Control

Cochi, A. ; Pardo, D. G.; Cossy, J.; Access to Optically Active 3-Aminopiperidines by Ring Expansion of Prolinols: Thermodynamic versus Kinetic Control; European Journal of Organic Chemistry; 2012; (10); 2023-2040

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A Flexible Approach to 6,5-Benzannulated Spiroketals

Wilson, Z. E.; Hubert, J. G.; Brimble, M. A.; A Flexible Approach to 6,5-Benzannulated Spiroketals; Eur. J. Org. Chem.; 2011; 3938-3945

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Heterogeneous Enantioselective Hydrogenation in a Continuousflow Fixed-bed Reactor System

SzÅ‘llÅ‘si, Gy.; Makra, Zs.; Fekete, M.; Fülöp, F.; Martók, M.; Heterogeneous Enantioselective Hydrogenation in a Continuousflow Fixed-bed Reactor System: Hydrogenation of Activated Ketones and Their Binary Mixtures on Pt-Alumina-Cinchona Alkaloid Catalysts; Catalysis Letters; 2012; 142; 889-894

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Chemoselective and Enantioselective Hydrogenations on Immobilized Complexes

Zsigmond, Á.; Notheisz, F.; Kluson, P.; Floris, T.;  Chemoselective and Enantioselective Hydrogenations on Immobilized Complexes; Catalysis by Metal Complexes; 2010; 33; 283-359

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Alkyne-Azide Cycloadditions with Copper Powder in a High-Pressure Continuous-Flow Reactor

Ötvös, S. B.; Mándity, I. M.; Kiss, L.; Fülöp, F.; Alkyne-Azide Cycloadditions with Copper Powder in a High-Pressure Continuous-Flow Reactor: High-Temperature Conditions versus the Role of Additives; Chem. Asian J.; 2013; 8; 800 - 808

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Papain-Specific Activating Esters in Aqueous Dipeptide Synthesis

de Beer, R.J.A.C.; Zarzycka, B.; Mariman, M.; Amatdjais- Groenen, H. I. V.; Mulders, M. J.; Quaedflieg, P. J. L. M.; van Delft, F. L.; Nabuurs, S. B.; Rutjes, F. P. J. T.; Papain-Specific Activating Esters in Aqueous Dipeptide Synthesis; ChemBioChem; 2012; 13; 1319-1326

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Single Operation Stereoselective Synthesis of Aerangis Lactones

Fink, M. J.; Schçn, M.; Rudroff, F.; Schnürch, M.; Mihovilovic, M. D.; Single Operation Stereoselective Synthesis of Aerangis Lactones: Combining Continuous Flow Hydrogenation and Biocatalysts in a Chemoenzymatic Sequence; Chem.Cat.Chem.; 2013; 5; 724 - 727

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Rapid Microfluidic Flow Hydrogenation for Reduction or Deprotection of 18F-Labeled Compounds

Liang, S. H.; Collier, T. L.; Rotstein, B. H.; Lewis, R.; Steck, M.; Vasdev, N.; Rapid Microfluidic Flow Hydrogenation for Reduction or Deprotection of 18F-Labeled Compounds; Chem. Commun., 2013; 49(78); 8755-8757

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Reversible and Efficient Inhibition of UDP-Galactopyranose Mutase by Electrophilic

Ansiaux, C.; N’Go, I.; Vincent, S. P.; Reversible and Efficient Inhibition of UDP-Galactopyranose Mutase by Electrophilic, Constrained and Unsaturated UDP-Galactitol Analogues; Chem. Eur. J.; 2012; 18; 14860-14866

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Total Synthesis, Stereochemical Assignment, and Biological Activity of Chamuvarinin and Structural Analogues

Total Synthesis, Stereochemical Assignment, and Biological Activity of Chamuvarinin and Structural Analogues; Florence, G. J.; Morris, J. C.; Murray, R. G.; Vanga, R. R.; Osler, J. D.; Smith, T. K.; Chemistry - A European Journal; 2013; 19(25); 8309-8320

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Multistep Continuous-Flow Synthesis in Medicinal Chemistry

Petersen, T. P.; Mirsharghi, S.; Rummel, P. C.; Thiele, S.; Rosenkilde, M. M.; Ritzén, A.; Ulven, T.; Multistep Continuous-Flow Synthesis in Medicinal Chemistry: Discovery and Preliminary Structure-Activity Relationships of CCR8 Ligands; Chemistry - A European Journal; 2013; 19(28); 9343-9350

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Site-Selective Deuterated-Alkene Synthesis with Palladium on Boron Nitride

Yabe, Y.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Site-Selective Deuterated-Alkene Synthesis with Palladium on Boron Nitride; Chemistry - A European Journal; 2013; 19; 484-488

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Design of a Highly Selective and Potent Class of Nonplanar Estrogen Receptor β Agonists

Sundén, H.; Ma, J. N.; Hansen, L. K.; Gustavsson, A. L.; Burstein, E. S.; Olsson, R.; Design of a Highly Selective and Potent Class of Nonplanar Estrogen Receptor β Agonists; Chem.Med.Chem; 2013; 8 (8); 1283 - 1294

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A remote-controlled adaptive medchem lab: an innovative approach to enable drug discovery in the 21st Century

Godfrey, A.G.; Masquelin, T.; Hemmerle, H..; A remote-controlled adaptive medchem lab: an innovative approach to enable drug discovery in the 21st Century; Drug Discov. Today; 2013; 18 (17-18); 795 - 802

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Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents

Marhadour, S.; Marchand, P.; Pagniez, F.; Bazin, M.A.; Picot, C.; Lozach, O.; Ruchaud, S.; Antoine, M.; Meijer, L.; Rachidi, N.; Le Pape, P.; Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents; European Journal of Medicinal Chemistry2012; 58; 543-556

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3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis; Ferrins, L.; Rahmani, R.; Sykes, M. L.; Jones, A. J.; Avery, V. M.; Teston, E.; Almohaywi, B.; Yin, J.; Smith, J.;  Hyland, C.; White, K. L.; Ryan, E.; Campbell, M.; Charman, S. A.; Kaiser, M.; Baell, J. B.; European Journal of Medicinal Chemistry; 2013; 66; 450- 465

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Synthesis of 4-Fluoromethylsydnones and their Participation in Alkyne Cycloaddition Reactions

Foster, R. S.; Adams, H.; Jakobi, H.; Harrity, J. P. A.; Synthesis of 4-Fluoromethylsydnones and their Participation in Alkyne Cycloaddition Reactions; J. Org. Chem.; 2013; 78(8); 4049-4064

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Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis

McQuade, D. T.; Seeberger, P. H.; Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis; J. Org. Chem.; 2013; 78(13); 6384-6389

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Enantioselective Synthesis of Bicyclo[2.2.2]octenones

Dong, S; Zhu, J.; Porco, J.A.; Enantioselective Synthesis of Bicyclo[2.2.2]octenones Using a Copper-Mediated Oxidative Dearomatization/[4 + 2] Dimerization Cascade; J. Am. Chem. Soc.; 2008; 130(9); 2738-2739

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De novo design, synthesis and pharmacological evaluation of new azaindole derivatives as dual inhibitors of Abl and Src kinases

Chevé, G.; Bories, C.; Fauvel, B.; Picot, F.; Tible, A.; Daydé-Cazals, B.; Loget, O.; Yasri, A.; De novo design, synthesis and pharmacological evaluation of new azaindole derivatives as dual inhibitors of Abl and Src kinases; Med. Chem. Commun; 2012; 3; 788-800

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Application of continuous flow and alternative energy devices for 5-hydroxymethylfurfural production

Schön, M.; Schnürch, M.; Mihovilovic, M. D.; Application of continuous flow and alternative energy devices for 5-hydroxymethylfurfural production; Mol Divers; 2011; 15; 639-643

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A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir

Dalla-Vechia, L.; Reichart, B.; Glasnov, T. N.; Miranda, L. S. M.; Kappe, C. O.; deSouza, R.; A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir; Org. Biomol. Chem.; 2013; 11; 6806 - 6813

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Diversity-Oriented Synthesis of Dibenzoazocines and Dibenzoazepines via a Microwave-Assisted Intramolecular A3-Coupling Reaction

Bariwal, J.B.; Ermolat’ev, D.S.; Glasnov, T.N.; Van Hecke, K.; Mehta, V.P.; Van Meervelt, L.; Kappe, C.O.; Van der Eycken, E.V.; Diversity-Oriented Synthesis of Dibenzoazocines and Dibenzoazepines via a Microwave-Assisted Intramolecular A3-Coupling Reaction; Org. Lett.; 2010; 12(12); 2774-2777

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Spirocyclic Dihydropyridines by Electrophile-Induced Dearomatizing Cyclization of N-Alkenyl Pyridinecarboxamides

Senczyszyn, J.; Brice, H.; Clayden, J.; Spirocyclic Dihydropyridines by Electrophile-Induced Dearomatizing Cyclization of N-Alkenyl Pyridinecarboxamides; Org. Lett.; 2013; 15(8); 1922-1925

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Lipase-Catalyzed Monostearin Synthesis Under Continuous Flow Conditions

Junior, I.I.; Flores, C.M.; Sutili, F.K.; Leite, S.G.F.; Miranda, L.S. de M.; Leal, I.C.R.; de Souza, R.O.M.A.; Lipase-Catalyzed Monostearin Synthesis Under Continuous Flow Conditions;  Org. Process Res. Dev.; 2012; 16 (5); 1098-1101

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Improved Continuous Flow Processing: Benzimidazole Ring Formation via Catalytic Hydrogenation of an Aromatic Nitro Compound

Chen, J.; Roemmele, R. C.; Przyuski, K.; Bakale, R. P.; Improved Continuous Flow Processing: Benzimidazole Ring Formation via Catalytic Hydrogenation of an Aromatic Nitro Compound; Org. Process Res. Dev.2014, 18 (11), pp 1427-1433

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Concise synthesis of a tetra- and a trisaccharide related to the repeating unit of the O-antigen from Providencia

Verma, P. R.; Mukhopadhyay, B.; Concise synthesis of a tetra- and a trisaccharide related to the repeating unit of the O-antigen from Providencia rustigianii O34 in the form of their p-methoxyhenyl glycosides; RSC Adv; 2013; 3; 201-207

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Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-Activity Relationship (SAR)

Pizzirani, D.; Pagliuca, C.; Realini, N.; Branduardi, D.; Bottegoni, G.; Mor, M.; Bertozzi, F.; Scarpelli, R.; Piomelli, D.; Bandiera, T.; Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-Activity Relationship (SAR); J. Med. Chem.; 2013; 56 (9); 3518-3530

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Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Cummings, M. D.; Lin, T.; Hu, L.; Tahri, A.; McDowan, D.; Amssoms, K.; Last, S.; Devogelaere, B., Rouan, M.; Vijgen, L., Berke, J. M.; Dehertogh, P.; Fransen, E.; Cleiren, E.; van der Helm, L.; Fanning, G.; Nyanguile, O.; Simmen, K.; Remoortere, P. V.; Raboisson, P.; Vendeville, S., Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase; J. Med. Chem.; 2014; 57 (5); 1880-1892

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Synthesis and Structure-Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives

Luci, D. K.; Jameson, J. B.; Yasgar, A.; Diaz, G.; Joshi, N.; Kantz, A.; Markham, K., Perry, S.; Kuhn, N.; Yeung, J., Kerns, E. H.; Schultz, L.; Holinstat, M.; Nadler, J. L.; Taylor-Fishwick, D. A.; Jadhav, A.; Simeonov, A.; Holman, T. R.; Maloney, D. J.; Synthesis and Structure-Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase; J. Med. Chem.; 2014; 57 (2); 495-506

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Synthesis of 3-Arylated 3,4-Dihydrocoumarins: Combining Continuous Flow Hydrogenation with Laccase-Catalysed Oxidation

Suljic, S.; Pietruszka, J.; Synthesis of 3-Arylated 3,4-Dihydrocoumarins: Combining Continuous Flow Hydrogenation with Laccase-Catalysed Oxidation; Adv. Synth. Catal.; 2014; 356; 1007-1020

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Synthesis of TAIW from TADBIW by Catalytic Hydrogenolysis Using a Continuous Flow Process

Dong, K.;Sun, C. H.; Song, J. W., Wei, G. X.; Pang, S. P.; Synthesis of 2,6,8,12-Tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane (TAIW) from 2,6,8,12-Tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazaisowurtzitane (TADBIW) by Catalytic Hydrogenolysis Using a Continuous Flow Process; OPRD; 2014; Article ASAP

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3-Aminoazetidin-2-one Derivatives as N-Acylethanolamine Acid Amidase (NAAA) Inhibitors Suitable for Systemic Administration

Fiasella, A.; Nuzzi, A.; Summa, M.; Armirotti, A.; Tarozzo, G.; Tarzia, G.; Mor, M.; Bertozzi, F.; Bandiera, T.; Piomelli, D.; 3-Aminoazetidin-2-one Derivatives as N-Acylethanolamine Acid Amidase (NAAA) Inhibitors Suitable for Systemic Administration; ChemMedChem; 2014; Early view

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Enantiomeric Separation of Bicyclo[2.2.2]octane-Based 2-Amino-3-Carboxylic Acids

Pataj, Z.; Ilisz, I.; Grecsó, N; Palkó, M.; Fülöp, F.; Armstrong, D. W.; Péter, A.; Enantiomeric Separation of Bicyclo[2.2.2]octane-Based 2-Amino-3-Carboxylic Acids on Macrocyclic Glycopeptide Chiral Stationary Phases; Chirality; 2014; 26; 200-208

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Evaluation dynamic kinetic resolution strategies in the asymmetric hydrosilylation of cyclic ketimines

Jones, S.; Zhao, P.; Evaluation dynamic kinetic resolution strategies in the asymmetric hydrosilylation of cyclic ketimines; Tetrahedron: Asymmetry; 2014; 25(3); 238-244

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Measurement of supramolecular effective molarities for intramolecular H-bonds in zinc porphyrin-imidazole complexes

Jinks, M. A.; Sun, H.; Hunter, C. A.; Measurement of supramolecular effective molarities for intramolecular H-bonds in zinc porphyrin-imidazole complexes; Org. Biomol. Chem.; 2014; 12; 1440-1447

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Synthesis of an azabicyclic framework towards (±)-actinophyllic acid

Mortimer, D.; Whiting, M.; Harrity, J. P. A.; Jones, S.; Coldham, I.; Synthesis of an azabicyclic framework towards (±)-actinophyllic acid; Tetrahedron Letters; 2014; 55; 1255-1257

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Chemistry of pyrrolizidine alkaloids revisited

Martineza, S. T.; Pinto, A. C.; Glasnov, T.; Kappe, C. O.; Chemistry of pyrrolizidine alkaloids revisited - semi-synthetic microwave and continuous-flow approaches towards Crotalaria-alkaloids; Tetrahedron Letters; 2014; 55(30); 4181-4184

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Systematic evaluation of the palladium-catalyzed hydrogenation under flow conditions

Hattori, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Systematic evaluation of the palladium-catalyzed hydrogenation under flow conditions; Tetrahedron; 2014; 70 (32); 4790-4798

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Intramolecular Aglycon Delivery Enables the Synthesis of 6‑Deoxy-β‑D-manno-heptosides

Kenfack, M. T.; Blériot, Y.; Gauthier, C.; Intramolecular Aglycon Delivery Enables the Synthesis of 6‑Deoxy-β‑D-manno-heptosides as Fragments of Burkholderia pseudomallei and Burkholderia mallei Capsular Polysaccharide; J. Org. Chem.; 2014; 79; 4615−4634

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Synthesis, Anti-tubulin and Antiproliferative SAR of Steroidomimetic Dihydroisoquinolinones

Leese, M. P.; Jourdan, F. L.; Major, M. R.; Dohle, W.; Thomas, M. P.; Hamel, E.; Ferrandis, E.; Mahon, M. F.; Newman, S. P.; Purohit, A.; Potter, B. V. L.; Synthesis, Anti-tubulin and Antiproliferative SAR of Steroidomimetic Dihydroisoquinolinones; ChemMedChem; 2014; 9; 798-812

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Flash carboxylation: fast lithiation-carboxylation sequence at room temperature in continuous flow

Pieber, B.; Glasnov, T.; Kappe, C. O..; Flash carboxylation: fast lithiation-carboxylation sequence at room temperature in continuous flow; RSC Adv.; 2014; 4; 13430-13433

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Fully Automated Sequence-Specific Synthesis of α-Peptides Using Flow Chemistry

Knudsen, K. R.; Ladlow, M.; Bandpey, Z.; Ley, S. V.; Fully Automated Sequence-Specific Synthesis of α-Peptides Using Flow Chemistry; J. Flow Chem.; 2014; 4(1); 18-21

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Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ‑Secretase Modulators

Pettersson, M.; Johnson, D. S.; Subramanyam, C.; Bales, K. R.; am Ende, C. W.; Fish, B. A.; Green, M. E.; Kauffman, G. W.; Mullins, P. B.; Navaratnam, T.; Sakya, S. M.; Stiff, C. M.; Tran, T. P.; Xie, L.; Zhang, L.; Pustilnik, L. R.; Vetelino, B. C.; Wood, K. M.; Pozdnyakov, N.; Verhoest, P. R.; O’Donnell. C. J.; Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ‑Secretase Modulators; J. Med. Chem.; 2014; 57; 1046−1062

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Hepatitis C Virus NS5A Replication Complex Inhibitors

Belema, M.; Nguyen, V. N.; Romine, J. L.; St. Laurent, D. R.; Lopez, O. D.; Goodrich, J. T.; Nower, P. T.; O’Boyle, D. R.; Lemm, J. A.; Fridell, R. A.; Gao, M.; Fang, H.; Krause, R. G.; Wang, Y.; Oliver, A. J.; Good, A. C.; Knipe, J. O.; Meanwell, N. A.; Snyder, L. B.; Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons; J. Med. Chem.; 2014; 57; 1995−2012

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Titanium Nitride-Nickel Nanocomposite as Heterogeneous Catalyst for the Hydrogenolysis of Aryl Ethers

Molinari, V.; Giordano, C.; Antonietti, M.; Esposito, D.; Titanium Nitride-Nickel Nanocomposite as Heterogeneous Catalyst for the Hydrogenolysis of Aryl Ethers; J. Am. Chem. Soc.; 2014; 136; 1758−1761

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Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1-Substituted Tetrahydroisoquinolines

Dohle, W.; Leese, M. P.; Jourdan, F. L.; Major, M. R.; Bai, R.; Hamel, E.; Ferrandis, E.; Kasprzyk, P. G.; Fiore, A.; Newman, S. P.; Purohit, A.; Potter, B. V. L.; Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1-Substituted Tetrahydroisoquinolines; ChemMedChem; 2014; 9; 350 - 370

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Synthesis, Structure-Activity, and Structure-Stability Relationships of NAAA Inhibitors

Vitale, R.; Ottonello, G.; Petracca, R.; Bertozzi, S. M.; Ponzano, S.; Armirotti, A.; Berteotti, A.; Dionisi, M.; Cavalli, A.; Piomelli, D.; Bandiera, T.; Bertozzi, F.; Synthesis, Structure-Activity, and Structure-Stability Relationships of 2-Substituted-N-(4-oxo-3-oxetanyl) N-Acylethanolamine Acid Amidase (NAAA) Inhibitors; ChemMedChem; 2014; 9; 323-336

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Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Ingham, R. J.; Battilocchio, C.; Hawkins, J. M.; Ley, S. V.; Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide; Beilstein J. Org. Chem.; 2014; 10; 641-652

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Green and scalable procedure for extremely fast ligandless Suzuki-Miyaura cross-coupling reactions in aqueous IPA

Mateos, C.; Rincón, H. A.; Martín-Hidalgo, B.; Villanueva, J.; Green and scalable procedure for extremely fast ligandless Suzuki-Miyaura cross-coupling reactions in aqueous IPA using solid-supported Pd in continuous flow; Tetrahedron Letters; 2014; 55 (27); 3701-3705

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From the Lindlar Catalyst to Supported Ligand-Modified Palladium Nanoparticles

Vilé, G.; Almora-Barrios, N.; Mitchell, S.; López, N.; Pérez-Ramírez, J.; From the Lindlar Catalyst to Supported Ligand-Modified Palladium Nanoparticles: Selectivity Patterns and Accessibility Constraints in the Continuous-Flow Three-Phase Hydrogenation of Acetylenic Compounds; Chem. Eur. J.; 2014; 20; 5926 - 5937

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Eco-efficiency Analysis for Intensified Production of an Active Pharmaceutical Ingredient: A Case Study

Denčić, I.; Ott, D.; Kralisch, D.; Noël, T.; Meuldijk, J.; de Croon, M.; Hessel, V.; Laribi, Y.; Perrichon, P.; Eco-efficiency Analysis for Intensified Production of an Active Pharmaceutical Ingredient: A Case Study; OPRD; 2014; Article ASAP

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Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labeling

Baer, S.; Nigro, J.; Madej, M. P.; Nisbet, R.M.; Suryadinata, R.; Coia, G.; Hong, L. P. T.; Adams, T. E.; Williams, C. C.; Nuttall, S. D.; Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labeling; Org. Biomol. Chem.; 2014; 12; 2675-2685

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Chemoselective flow hydrogenation approaches to isoindole-7-carboxylic acids and 7-oxa-bicyclio [2.2.1]heptanes

Hizartzidis, L.; Tarleton, M.; Gordon, C. P.; McCluskey, A.; Chemoselective flow hydrogenation approaches to isoindole-7-carboxylic acids and 7-oxa-bicyclio [2.2.1]heptanes; RSC Adv.; 2014; 4; 9709-9722

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Syntheses of Four Enantiomers of 2,3-Diendo- and 3-Endo-aminobicyclo[2.2.2]oct-5-ene-2-exo-carboxylic Acid

Palko, M.; Hanninen, M. M.; Sillanpaa, R.; Fulop, F.; Syntheses of Four Enantiomers of 2,3-Diendo- and 3-Endo-aminobicyclo[2.2.2]oct-5-ene-2-exo-carboxylic Acid and Their Saturated Analogues; Molecules; 2013; 18; 15080-15093

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α-1,4-Galacrosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins

Simerska, P.; Christie, M. P.; Goodwin, D.; Jen, F. E.-C.; Jennings, M. P.; Toth, I.; α-1,4-Galacrosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins; Journal of Molecular Catalysis B: Enzymatic; 2013; 97; 196-202

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Enzymatic reactions for the preparation of homocalycotomine enantiomers

Schönstein, L.; Forró, E.; Fulop, F.; Enzymatic reactions for the preparation of homocalycotomine enantiomers; Tetrahedron: Asymmetry; 2013; 24; 1059-1062

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Flow synthesis of annulated 5-aryl-substituted pyridines

Martin, R. E.; Lenz, M.; Akzieu, T.; Aebi, J. D.; Forzy, L.; Flow synthesis of annulated 5-aryl-substituted pyridines by tandem intramolecular inverse-electron-demand hetero-/retro-Diels-Alder reaction; Tetrahedron Letters; 2013; 54; 6703-6707

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Flow Synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe

Plutschack, M. B.; McQuade, D. T.; Valenti, G.; Seeberger, P. H.; Flow Synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe; Beilstein J. Org. Chem.; 2013; 9; 2022-2027

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Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a

Chassagne, P.; Raibaut, L.; Guerreiro, C.; Mulard, L. A.; Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxidation; Tetrahedron; 2013; 10337-10350

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Synthesis and photophysical characterization of 1- and 4-(purinyl)triazoles

Redwan, I. N.; Bliman, D.; Tokugawa, M.; Lawson, C.; Grøtli, M.; Synthesis and photophysical characterization of 1- and 4-(purinyl)triazoles; Tetrahedron; 2013; 69 (42); 8857-8864

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Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a]pyridine

Bazin, M. An.; Marhadour, S.; Tonnerre, A.; Marchand, P.; Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a]pyridine: expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines; Tetrahedron Letters; 2013; 54 (39); 5378-5382

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Synthesis of γ-valerolactone using a continuous-flow reactor

Tukacs, J. M.; Jones, R. V.; Darvas, F.; Lezsák, G.; Dibó, G.; Mika, L. T.; Synthesis of γ-valerolactone using a continuous-flow reactor; RSC Adv.; 2013; 3, 16283-16287

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otal syntheses of the dipyrrolobenzoquinone (+) -terreusinone enabled by an evaluation of 4-methylpent-1-yn-3-ols

Wang, C.; Sperry, J.;  Total syntheses of the dipyrrolobenzoquinone (+) -terreusinone enabled by an evaluation of 4-methylpent-1-yn-3-ols in the Larock indole synthesis; Tetrahedron Letters; 2013; 69; 4563-4577

DOI: 10.1016/j.tet.2013.04.025

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Continuous-flow enzymatic resolution strategy for the acylation of amino alcohols with a remote stereogenic centre

Schönstein, L.; Forró, E.; Fülöp, F.; Continuous-flow enzymatic resolution strategy for the acylation of amino alcohols with a remote stereogenic centre: synthesis of calycotomine enantiomers; Tetrahedron: Asymmetry; 2013; 24; 202-206

DOI: 10.1016/j.tetasy.2013.01.006

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Chemical and bacterial reduction of azo-probes:monitoring a conformational change using fluorescence spectroscopy

Rattray, N. J. W.; Zalloum, W. A.; Mansell, D.; Latimer, J.; Jaffar, M.; Bichenkova, E. V.; Freeman, S.; Chemical and bacterial reduction of azo-probes:monitoring a conformational change using fluorescence spectroscopy; Tetrahedron; 2013; 69; 2758-2766

DOI: 10.1016/j.tet.2013.01.086

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High-speed microwave assisted synthesis of SEA0400 — a selective inhibitor of the Na+/Ca2+ exchanger

Cruz, G.G.; Groschner, K.;  Kappe, C. O.; Glasnov; T. N.; High-speed microwave assisted synthesis of SEA0400 — a selective inhibitor of the Na+/Ca2+ exchanger; Tetrahedron Letters; 2012; 53; 3731-3734

DOI: 10.1016/j.tetlet.2012.04.120

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Metal-catalyzed amidation

Roy, S.; Roy, S.; Gribble, G. W.;  Metal-catalyzed amidation; Tetrahedron; 2012; 68; 9867 - 9923

DOI: 10.1016/j.tet.2012.08.065

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Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors

Tite, T.; Tomas, L.; Docsa, T.; Gergely, P.; Kovensky, J.; Gueyrard, D.; Wadouachi, A.; Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors; Tetrahedron Letters; 2012; 53; 959-961

DOI: 10.1016/j.tetlet.2011.12.049

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Scalable synthesis of an integrin-binding peptide mimetic for biomedical applications

Riches, A. G.;  Cablewski, T.; Glattauer, V.;  Thissen, H.;  Meagher, L.; Scalable synthesis of an integrin-binding peptide mimetic for biomedical applications; Tetrahedron; 2012; 68; 9448 - 9455

DOI: 10.1016/j.tet.2012.09.002

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Synthesis of oxaspiropiperidines as a strategy for lowering logD

Cernak, T.;  Dykstra, K.; Levorse, D.; Verras, A.; Balkovec, J.; Nargund, R.; DeVita, R.; Synthesis of oxaspiropiperidines as a strategy for lowering logD; Synthesis of oxaspiropiperidines as a strategy for lowering logD; Tetrahedron Letters; 2011; 52; 6457-6459

DOI: 10.1016/j.tetlet.2011.09.100

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Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions Using a Modular Flow Reactor

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions Using a Modular Flow Reactor; Synlett; 2010; 5; 749-752

DOI: 10.1055/s-0029-1219344

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Synthesis and reactivity of 3-amino-1H-pyrazole[4,3-c]pyridine-4(5H)-ones: development of a novel kinase-focussed library

Smyth, L.A.; Matthews, T.P.; Horton, P.N.; Hursthouse, M.B.; Collins, I.; Synthesis and reactivity of 3-amino-1H-pyrazole[4,3-c]pyridine-4(5H)-ones: development of a novel kinase-focussed library; Tetrahedron; 2010; 66; 2843-2854

DOI: 10.1016/j.arabjc.2011.09.013

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Microwave-Assisted Solution Phase Synthesis of Dihydropyrimidine C5 Amides and Esters

Desai, B.; Dallinger, D.; Kappe, C.O., Microwave-Assisted Solution Phase Synthesis of Dihydropyrimidine C5 Amides and Esters; Tetrahedron; 2006; 62; 4651-4664

DOI: 10.1016/j.tet.2005.12.061

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Microwave heating and conventionally-heated continuous-flow processing

Rudzinski, D. M.; Leadbeater, N. E.; Microwave heating and conventionally-heated continuous-flow processing as tools for performing cleaner palladium-catalyzed decarboxylative couplings using oxygen as the oxidant - a proof of principle study; Green Processing and Synthesis; 2013; 2 (4); 323-328

DOI: 10.1515/gps-2013-0043

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Ask the Experts: The challenges and benefits of flow chemistry to optimize drug development

Richardson; P.; Ask the Experts: The challenges and benefits of flow chemistry to optimize drug development; Future Medicinal Chemistry; 2012; 4(14); 1779-1789

DOI: 10.4155/fmc.12.106

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Adaptive Process Optimization for Continuous Methylation of Alcohol in Supercritical Carbon Dioxide

Bourne, R. A.; Skilton, R. A.; Parrott, A. J.; Irvinem D. J.; Poliakoff, M.; Adaptive Process Optimization for Continuous Methylation of Alcohol in Supercritical Carbon Dioxide; OPRD; 2011; 15(4); 932-938

DOI: 10.1021/op200109t

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Multijet Oscillating Disc Millireactor: A Novel Approach for Continuous Flow Organic Synthesis

Liguori, L.; Bjørsvik, H. R.; Multijet Oscillating Disc Millireactor: A Novel Approach for Continuous Flow Organic Synthesis; Org. Process Res. Dev.; 2011; 15(5); 997-1009

DOI: 10.1021/op2000699

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Green Chemistry Articles of Interest to the Pharmaceutical Industry

Andrews, I.; Dunn, P.; Hayler, J.; Himkley, B.; Hughes, D.; Kaptein, B.; Lorenz, K.; Methew, S.; Rammeloo, T.; Wang, L.; Wells, A.; White, T.D.; Green Chemistry Articles of Interest to the Pharmaceutical Industry; Org. Process Res. Dev.; 2011; 15; 748-756

DOI: 10.1021/op200128q

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Combinatorial Chemistry Online

Terrett, N.K.; Combinatorial Chemistry Online; Comb Chem - An Online Journal; 2011; 13; 33-35

DOI: 10.1016/j.comche.2011.07.002

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Stereo- and Chemoselective Character of Supported CeO2 Catalysts for Continuous-Flow Three-Phase Alkyne Hydrogenation

Vilé, G.; Wrabetz, S.; Floryan, L.; Schuster, M. E.; Girgsdies, F.; Teschner, D.; Pérez-Ramírez, J., Stereo- and Chemoselective Character of Supported CeO2 Catalysts for Continuous-Flow Three-Phase Alkyne Hydrogenation; ChemCatChem; 2014; Early view

DOI: 10.1002/cctc.201402124

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Easy Access to Ni3N- and Ni-Carbon Nanocomposite Catalysts

Clavel, G.; Molinari, V.; Kraupner, A.; Giordano, C.; Easy Access to Ni3N- and Ni-Carbon Nanocomposite Catalysts; Chem. Eur. J.; 2014; 20 (29); 9018-9023

DOI: 10.1002/chem.201400398

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FeNi nanoparticles with carbon armor as sustainable hydrogenation catalyst: towards biorefineries

Chieffi, G.; Giordano, C.; Antonietti, M.; Esposito, D.; FeNi nanoparticles with carbon armor as sustainable hydrogenation catalyst: towards biorefineries; Journal of Materials Chemistry A; 2014; Accepted Manuscript

DOI: 10.1039/C4TA02457E

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Chemical synthesis of a tetrasaccharide related to the exocellular polysaccharide from Rhodococcus sp. RHA1

Budhadev, D.; Mukhopadhyay, B.; Chemical synthesis of a tetrasaccharide related to the exocellular polysaccharide from Rhodococcus sp. RHA1; Carbohydrate Research; 2014; Accepted Manuscript

DOI: 10.1016/j.carres.2014.05.018

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Microreactors for peptide synthesis: looking through the eyes of twenty first century!!!

Ramesh, S.; Cherkupally, P.; de la Torre, B. G.; Govender, T.; Kruger, H.G.; Albericio, F. Microreactors for peptide synthesis: looking through the eyes of twenty first century!!!; Amino Acids; 2014; 46; 2091-2104

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Synthesis of the tetrasaccharide repeating unit of the O-glycan

Pal, K, B.; Mukhopadhyay, B.; Synthesis of the tetrasaccharide repeating unit of the O-glycan from the polar flagellum flagellin of Azospirillum brasilense Sp7, Carbohydrate Research; 2014; 400; 9-13

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Towards the development of chromone-based MEK1/2 modulators

Redwan, I. N.; Dyrager, C.; Solano, C.; de Troconiz, G. F.; Voisin, L.; Bliman, D.; Meloche, S.; Grøtli, M.; Towards the development of chromone-based MEK1/2 modulators; European Journal of Medicinal Chemistry; 2014; 85; 127-138

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Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations

Baumann, M.; Baxendale, I. R.; Hornung, C. H.; Ley, S. V.; Rojo, M. V; Roper, K. A.; Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations; Molecules; 2014; 19; 9736-9759

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Beyond the use of modifiers in selective alkyne hydrogenation: silver and gold nanocatalysts in flow mode

Vile, G.; Perez-Ramırez, J.; Beyond the use of modifiers in selective alkyne hydrogenation: silver and gold nanocatalysts in flow mode for sustainable alkene production; Nanoscale; 2014; 6;13476-13482

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Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks

Wlochal, J.; Davies, R. D. M.; Burton, J.; Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks; Org. Lett.; 2014; 16, 4094−4097

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SAR216471, a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist

Boldron, C.; Besse, A.; Bordes, M.; Tissandié, S.; Yvon, X.; Gau, B.; Badorc, A.; Rousseaux, T.; Barré, G.; Meneyrol, J.; Zech, G.; Nazare, M.; Fossey, V.; Pflieger, A.; Bonnet-Lignon, S.; Millet,L.; Briot, C.; Dol, F.; Hérault, J.; Savi, P.; Lassalle, G.; Delesque, N.; Herbert, J.; Bono, F.; N-[6-(4-Butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist; J. Med. Chem.; 2014; 57 (17); 7293-7316

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Synthesis of aromatic 13C/2H-α-ketoacid precursors to be used in selective phenylalanine and tyrosine protein labelling

Lichtenecker, R. J.; Synthesis of aromatic 13C/2H-α-ketoacid precursors to be used in selective phenylalanine and tyrosine protein labelling; Org. Biomol. Chem.; 2014; 12; 7551-7560

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Benzoxazinone synthesis via Passerini-Smiles couplings

Martinand-Lurin, E.; El Kaïm, L.; Grimaud, L.; Benzoxazinone synthesis via Passerini-Smiles couplings; Tetrahedron Letters; 2014; 55; 5144-5146

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Synthesis of Cross-Linked Glycopeptides and Ureas by a Mechanochemical, Solvent-Free Reaction

Kumar, V.; Giri, S. K.; Venugopalan, P.; Kartha, K. P. R.; Synthesis of Cross-Linked Glycopeptides and Ureas by a Mechanochemical, Solvent-Free Reaction and Determination of Their Structural Properties by TEM and X-ray Crystallography; ChemPlusChem; 2014; 79 (11); 1605 - 1613

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Synthesis, Biological Evaluation, and Molecular Modeling of New PDE4D Inhibitors

Brullo, C.; Massa, M.; Rocca, M; Rotolo, C.; Guariento, S.; Rivera, D.; Ricciarelli, R.; Fedele, E.; Fossa, P.; Bruno, O.; Synthesis, Biological Evaluation, and Molecular Modeling of New 3‑(Cyclopentyloxy)-4-methoxybenzaldehyde O‑(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors; J. Med. Chem.; 2014; 57 (16); 7061-7072

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Stereoselective syntheses and transformations of chiral 1,3-aminoalcohols and 1,3-diols derived from nopinone

Szakonyi, Zs.; Gonda, T.; Ötvös, S. B.; Fülöp, F.; Stereoselective syntheses and transformations of chiral 1,3-aminoalcohols and 1,3-diols derived from nopinone; Tetrahedron: Asymmetry; 2014; 25; 1138-1145

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Immobilized Iron Oxide Nanoparticles as Stable and Reusable Catalysts for Hydrazine-Mediated Nitro Reductions in Continuous Flow

Moghaddam, M. M.; Pieber, B.; Glasnov, T.; Kappe, C. O.; Immobilized Iron Oxide Nanoparticles as Stable and Reusable Catalysts for Hydrazine-Mediated Nitro Reductions in Continuous Flow; ChemSusChem; 2014; 7(11); 3122-3131

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Selective Hydrogenation of Nitro Compounds using Palladium Nanoparticles Supported on Amino- Functionalized Mesocellular Foam

Verho, O.; Gustafson, K. P. J.; Nagendiran, A.; Tai, C.; Backvall, J.; Mild and Selective Hydrogenation of Nitro Compounds using Palladium Nanoparticles Supported on Amino- Functionalized Mesocellular Foam; ChemCatChem; 2014; 6; 3153 - 3159

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Continuous flow hydrogenation reactions by Pd catalysts onto hybridZrO2/PVA materials

Liguoria, F.; Barbaroa, P.; Sawaba, H.; Continuous flow hydrogenation reactions by Pd catalysts onto hybridZrO2/PVA materials; Applied Catalysis A: General; 2014; 488; 58-65

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Synthesis of α‑Substituted Vinylsulfonium Salts and Their Application as Annulation Reagents

Matlock, J. V.; Fritz, S. P.; Harrison, S. A.; Coe, D. M.; McGarrigle, E. M.; Aggarwal, V. K.; Synthesis of α‑Substituted Vinylsulfonium Salts and Their Application as Annulation Reagents in the Formation of Epoxide and Cyclopropane-Fused Heterocycles; J. Org. Chem.; 2014; 79; 10226−10239

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Concise Synthesis of Vesnarinone and Its Analogues by Using Pd-Catalyzed C-N Bond-Forming Reactions

See, Y. Y.; Dang, T. T.; Chen, A.; Seayad, A. M.; Concise Synthesis of Vesnarinone and Its Analogues by Using Pd-Catalyzed C-N Bond-Forming Reactions; Eur. J. Org. Chem.; 2014; 7405-7412

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Expanding the Utility of Flow Hydrogenation – A Robust Protocol Restricting Hydrodehalogenation

Hizartzidis, L.; Cossar, P. J.; Robertson, M. J.; Simone, M. I.; Young, K. A.; McCluskeya, A.; Gordona, C. P.; Expanding the Utility of Flow Hydrogenation - A Robust Protocol Restricting Hydrodehalogenation; RSC Adv.; 2014; 4; 56743-56748

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Total Synthesis of Aignopsanes, A Class of Sesquiterpenes

Bürki, C.; Bonjoch, J.; Bradshaw, B.; Villa, G.; Renaud, P.; Total Synthesis of Aignopsanes, A Class of Sesquiterpenes: (+)-Aignopsanoic Acid A, (-)-Methyl Aignopsanoate A, and (-)-Isoaignopsanoic A; Chem. Eur. J.; 2015; 21 (1); 395 - 401

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Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models

Patel, S.; Cohen, F.; Dean, B. J.; De La Torre, K.; Deshmukh, G.; Estrada, A. A.; Ghosh, A. S.; Gibbons, P.; Gustafson, A.; Huestis, M. P.; Le Pichon, C. E.; Lin, H.; Liu, W.; Liu, X.; Liu, Y.; Ly, C. Q.; Lyssikatos, J. P.; Ma, C.; Scearce-Levie, K.; Shin, Y. G.; Solanoy, H.; Stark, K. L.; Wang, J.; Wang, B:; Zhao, X.; Lewcock, J. W.; Siu, M.; Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models; J. Med. Chem.; 2015; 58 (1); 401-418

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Novel derivatives of usnic acid effectively inhibiting reproduction of influenza A virus

Shtro, A. A.; Zarubaev, V. V.; Luzina, O. A.; Sokolov, D. N.; Kiselev, O. I.; Salakhutdinov, N. F.; Novel derivatives of usnic acid effectively inhibiting reproduction of influenza A virus; Bioorganic & Medicinal Chemistry; 2014; 22 (24); 6826-6836

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Total Synthesis of the Macrocyclic N‑Methyl Enamides Palmyrolide A and 2S‑Sanctolide A

Wadsworth, A. D.; Furkert, D. P.; Brimble, M. A.; Total Synthesis of the Macrocyclic N‑Methyl Enamides Palmyrolide A and 2S‑Sanctolide A; J. Org. Chem.; 2014; 79 (22); 11179-11193

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Chemical Assembly Systems: Layered Control for Divergent, Continuous, Multistep Syntheses of Active Pharmaceutical Ingredients

Ghislieri, D.; Gilmore, K.; Seeberger, P. H.; Chemical Assembly Systems: Layered Control for Divergent, Continuous, Multistep Syntheses of Active Pharmaceutical Ingredients; Angew. Chem. Int. Ed.; 2014; 53; 1 - 6

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Aerobic flow oxidation of alcohols in water catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

Osako, T.; Toriia, K.; Uozumi, Y.; Aerobic flow oxidation of alcohols in water catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer; RSC Adv.; 2015; 5; 2647-2654

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Life Cycle Analysis within Pharmaceutical Process Optimization and Intensification

Ott, D.; Kralisch, D.; Dencic, I.; Hessel, V.; Laribi, Y.; Perrichon, P. D.; Berguerand, C.; Kiwi-Minsker, L.; Loeb, P.; Life Cycle Analysis within Pharmaceutical Process Optimization and Intensification: Case Study of Active Pharmaceutical Ingredient Production; ChemSusChem; 2014; 7; 3521 - 3533

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Synthesis of Novel Camphor-Derived Bifunctional Thiourea Organocatalysts

Ricko, S.; Golobic, A.; Svete, J.; Stanovnik, B.; Groselj, U.; Synthesis of Novel Camphor-Derived Bifunctional Thiourea; Chirality; 2015; 27 (1); 39-52

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Facile access to new C-glycosides and C-glycoside scaffolds incorporating functionalised aromatic moieties

Redpath, P.; Ness, K. A.; Rousseau, J.; Macdonald, S. J. F.; Migaud, M. E.; Facile access to new C-glycosides and C-glycoside scaffolds incorporating functionalised aromatic moieties; Carbohydrate Research; 2015; 402; 25-34

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Highly Selective Continuous-Flow Synthesis of Potentially Bioactive Deuterated Chalcone Derivatives

Hsieh, C.; Otvos, S. B.; Wu, Y.; Mandity, I. M.; Chang, F.; Fulop, F.; Highly Selective Continuous-Flow Synthesis of Potentially Bioactive Deuterated Chalcone Derivatives; ChemPlusChem; 2015; 80(5); 859-864

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A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

Viviano, M.; Milite, C.; Rescigno, D.; Castellano, S.; Sbardella, G.; A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery; RSC Adv.; 2015; 5; 1268-1273

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Bicyclic naphthenic acids in oil sands process water: Identification bycomprehensive multidimensional GC-MS

Wilde, M. J.; West, C. E.; Scarlett, A. G.; Jones, D.; Frank, R. A.; Hewitt, L. M.; Rowland, S. J.; Bicyclic naphthenic acids in oil sands process water: Identification bycomprehensive multidimensional gas chromatography-massspectrometry; Journal of Chromatography A; 2015; 13; 74-87

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Iridium(I)-Catalyzed Ortho-Directed Hydrogen Isotope Exchange in Continuous-Flow Reactors

Habraken, E. R. M.; Haspeslagh, P.; Vliegen, M.; Noel, T.; Iridium(I)-Catalyzed Ortho-Directed Hydrogen Isotope Exchange in Continuous-Flow Reactors; Journal of Flow Chemistry; 2015; 5 (1); 2-5

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Identification of a Novel Orally Bioavailable Phosphodiesterase 10A Inhibitor with Efficacy in Animal Models of Schizophrenia

Bartolomee-Nebreda, J. M.; de Diego, S. A. A.; Artola, M.; Delgado, F.; Delgado, O.; Martin-Martin, M. L.; Martinez-Viturro, C. M.; Pena, M. A.; Tong, H. M.; Gool, M. V.; Alonso, J. M.; Fontana, A.; Macdonald, G. J.; Megens, A.; Langlois, X.; Somers, M.; Vanhoof, G.; Conde-Ceide, S.; Identification of a Novel Orally Bioavailable Phosphodiesterase 10A (PDE10A) Inhibitor with Efficacy in Animal Models of Schizophrenia; J. Med. Chem.; 2015; 58 (2); 978-993

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Synthesis of Condensed Heterocycles by the Gould−Jacobs Reaction in a Novel Three-Mode Pyrolysis Reactor

Lengyel, L.; Sipos, G.; Sipocz, T.; Vago, T.; Dorman, Gy.; Gerencser, J.; Makara, G.; Darvas, F.; Synthesis of Condensed Heterocycles by the Gould−Jacobs Reaction in a Novel Three-Mode Pyrolysis Reactor; Org. Process Res. Dev.; 2015; 19 (3); 399-409

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Microreactors: A new concept for chemical synthesis and technological feasibility

Nemethne-Sovago, J.; Benke, M.; Microreactors: A new concept for chemical synthesis and technological feasibility; Materials Science and Engineering; 2014; 39; 89 - 101

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Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction

Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction; Liu, Q.; Wu, K.; Cheng, Y., Lu, L.; Xiao, E.; Zhang, Y.; Deng, Z.; Liu, T.; Metabolic Engineering; 2015; 28; 82-90

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Expanding the toolbox of asymmetric organocatalysis by continuous-flow process

Finelli, F. G.; Miranda, L. S. M.;  de Souza, R. O. M. A.; Expanding the toolbox of asymmetric organocatalysis by continuous-flow process; Chem. Commun.; 2015; 51; 3708-3722

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Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous Flow System

Hattori, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous Flow System; Catalysts; 2015; 5; 18-25

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Benchmarking Immobilized Di- and Triarylphosphine Palladium Catalysts for Continuous-Flow Cross-Coupling Reactions

Greco, R.; Goessler, W.; Cantillo, D.; Kappe, C. O.; Benchmarking Immobilized Di- and Triarylphosphine Palladium Catalysts for Continuous-Flow Cross-Coupling Reactions: Efficiency, Durability, and Metal Leaching Studies; ACS Catal.; 2015; 5; 1303-1312

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Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies

Bach, A.; Pizzirani, D.; Realini, N.; Vozella, V.; Russo, D.; Penna, I.; Melzig, L.; Scarpelli, R.; Piomelli, D.; Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies; J. Med. Chem., 2015, 58 (23), 9258-9272

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Hazards associated with laboratory scale hydrogenations

Chandra, T.; Zebrowski; J. P.; Hazards associated with laboratory scale hydrogenations; Journal of Chemical Health and Safety; Available online 2 November 2015

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Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides

Furlotti, G.; Alisi, M. A.; Cazzolla, N.; Dragone, P.; Durando, L.; Magarò, G.; Mancini, F.; Mangano, G.; Ombrato, R.; Vitiello, M.; Armirotti, A.; Capurro, V.; Lanfranco, M.; Ottonello, G.; Summa, M.; Reggiani, A.; Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders; J. Med. Chem.; 2015; 58 (22); 8920-8937

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An efficient enzymatic method for the preparation of a key Taxol side-chain intermediate

Galla, Zs.; Beke, F.;Forró, E.;Fülöp, F.; Enantioselective hydrolysis of 3,4-disubstituted β-lactams. An efficient enzymatic method for the preparation of a key Taxol side-chain intermediate; Journal of Molecular Catalysis B: Enzymatic; 2016; 123; 107-112

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Preclinical Characterization of the FAAH Inhibitor JNJ-42165279

Keith, J. M.; Jones, W. M.; Tichenor, M.; Liu, J.; Seierstad, M.; Palmer, J. A.; Webb, M.; Karbarz, M.; Scott, B. P.; Wilson, S. J.; Luo, L.; Wennerholm, M. L.; Chang, L.; Rizzolio, M.; Rynberg, R.;Chaplan, S. R.; Breitenbucher, J. G.; Preclinical Characterization of the FAAH Inhibitor JNJ-42165279; ACS Med. Chem. Lett.; 2015; 6 (12); 1204-1208

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Synthesis, Biological Evaluation and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor

Schembri, L. S.; Stoddart, L. A.; Briddon, S. J.; Kellam, B.; Canals, M.; Graham, B.; Scammells, P. J.; Synthesis, Biological Evaluation and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor; J. Med. Chem.; 2015; 58 (24); 9754-9767

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Convergent synthesis of the hexasaccharide related to the repeating unit of the O-antigen from E. coli O120

Budhadev, D.; Mukhopadhyay, B.; Convergent synthesis of the hexasaccharide related to the repeating unit of the O-antigen from E. coli O120; RSC Adv.; 2015; 5; 98033-98040

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Pt-cinchonidine catalyzed asymmetric catalytic cascade reaction of 2-nitrophenylpyruvates in flow system

Kovács, L.; SzÅ‘llÅ‘si, G.; Fülöp, F.; Pt-cinchonidine catalyzed asymmetric catalytic cascade reaction of 2-nitrophenylpyruvates in flow system; Journal of Flow Chemistry2015; 5(4); 210-215

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Nanocatalysis in Flow

Ricciardi, R.; Huskens, J.; Verboom, W.; Nanocatalysis in Flow; ChemSusChem2015; 8(16); 2586-2605

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Multistep Continuous-Flow Synthesis of Condensed Benzothiazoles

Lövei, K.; Greiner, I.; Éles, J.; Szigetvári, Á.; Dékány, M.; Lévai, S.; Novák, Z.; Túrós, I. Gy.; Multistep Continuous-Flow Synthesis of Condensed Benzothiazoles; Journal of Flow Chemistry; 2015; 5(2); 74-81

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Recent advances in micro reaction technology

Wiles, C.; Watts, P.; Recent advances in micro reaction technology; Chemical Communications; 2011; 47(23); 6512-6535

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Valorization of lignin waste from hydrothermal treatment of biomass

Chieffti, G.; Fechler, N.; Esposito, D.; Valorization of lignin waste from hydrothermal treatment of biomass: towards porous carbonaceous composites for continuous hydrogenation; RSC Advances; 2015; 5(78); 63691-63696

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Continuous-Flow Synthesis of Nonpeptidal bis-Tetrahydrofuran Moiety of Darunavir

Leão, C. A. R.; de O. Lopes, R.; de M. Bezerra, de M. A.; Muniz, M. N.; Casanova, B. B.; Gnoatto, S. C. B.; Gosmann, G.; Kocsis, L.; de Souza, R. O. M. A.; de M. Miranda, L. S.; Studies on the Continuous-Flow Synthesis of Nonpeptidal bis-Tetrahydrofuran Moiety of Darunavir; Journal of Flow Chemistry; 2015; 5(4); 216-219

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Synthesis of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease

Alexandre, F.Brandt, G.Caillet, C.Chaves, D.Convard, T.Derock, M.; Gloux, D.Griffon, Y.; Lallos, L.; Leroy, F.; Liuzzi, M.; Loi, A.Moulat, L.; Musiu, C.; Parsy, C.; Rahali, H.; Roques, V.; Seifer, M.; Standring, D.; Surleraux, D.; Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease; Bioorganic & Medicinal Chemistry Letters; 2015; 25(18); 3984-3991

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Optimization of Novel Indazoles for the Treatment of Respiratory Disease

Down, K.; Amour, A.; Baldwin, I. R.; Cooper, A. W. J.; Deakin, A. M.; Felton, L. M.; Guntrip, S. B.; Hardy, C.; Harrison, Z. A.; Jones, K. L.; Jones, P.; Keeling, S. E.; Le, J.; Livia, S.; Lucas, F.; Lunniss, C. J.; Parr, N. J.; Robinson, E.; Rowland, P.; Smith, S.; Thomas, D. A.; Vitulli, G.; Washio, Y.; Hamblin, J. N.; Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease; Journal of  Medicinal Chemistry; 2015; 58(18); 7381-7399

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Enantiodivergent Synthesis of Bis-Spiropyrrolidines via Sequential Interrupted and Completed (3 + 2) Cycloadditions

Conde, E.; Rivilla, I.; Larumbe, A.; Cossío F. P.; Enantiodivergent Synthesis of Bis-Spiropyrrolidines via Sequential Interrupted and Completed (3 + 2) Cycloadditions; Journal of Organic Chemistry; 2015; 80(23); 11755-11767

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Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors

Bamborough, P.; Chung, C.; Furze, R. C.; Grandi, P.; Michon, A.; Sheppard, R. J.; Barnett, H.; Diallo, H.; Dixon, D. P.; Douault, C.; Jones, E. J.; Karamshi, B.; Mitchell, D. J.; Prinjha, R. K.; Rau, C.; Watson, R. J.; Werner, T.; Demont, E. H.; Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors; Journal of Medicinal Chemistry; 2015; 58(15); 6151-6178

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The expanding utility of continuous flow hydrogenation

Cossar, P. J.; Hizartzidis, L.; Simone, M. I.; McCluskey A.; Gordon, C. P.; The expanding utility of continuous flow hydrogenation; Organic & Biomulecular Chemistry2015; 13; 7119-7130

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An efficient and more sustainable one-step continuous-flow multicomponent synthesis approach to chromene derivatives


Vaddula, B. R.; Yalla, S.; Gonzalez, M. A.; An efficient and more sustainable one-step continuous-flow multicomponent synthesis approach to chromene derivatives; Journal of Flow Chemistry; 2015; 5(3); 172-177

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Monitoring Glycan-Protein Interactions by NMR Spectroscopic Analysis


Calle, L. P.; Echeverria, B.; Franconetti, A.; Serna, S.; Fernández-Alonso, M. C.; Diercks, T.; Cañada, F. J.; Ardá, A.; Reichardt, N. C.; Jiménez-Barbero, J.; Monitoring Glycan-Protein Interactions by NMR Spectroscopic Analysis: A Simple Chemical Tag That Mimics Natural CH-π Interactions; Chemistry; 2015; 21(32); 11408-11416

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Structural Identification of Petroleum Acids by Conversion to Hydrocarbons and Multidimensional GC-MS

Wilde, M. J.; Rowland S. J.; Structural Identification of Petroleum Acids by Conversion to Hydrocarbons and Multidimensional Gas Chromatography-Mass Spectrometry; Analytical Chemistry; 2015; 87(16); 8457-8465

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Flow chemistry vs. flow analysis

Trojanowicz, M.; Flow chemistry vs. flow analysis; Talanta; 2016; 146; 621-640

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Selective Liquid-Phase Hydrogenation of a Nitro Group in Substituted Nitrobenzenes

Nuzhdin, A. L.; Moroz, B. L.; Bukhtiyarova, G. A.; Reshetnikov, S. I.; Pyrjaev, P. A.; Aleksandrov P. V.; Bukhtiyarov, V. I.; Selective Liquid-Phase Hydrogenation of a Nitro Group in Substituted Nitrobenzenes over Au/Al2O3 Catalyst in a Packed-Bed Flow Reactor; ChemPlusChem; 2015; 80(12); 1741-1749

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Stereoselective Total Synthesis of the Marine Macrolide Sanctolide A


Yadav, J. S.; Suresh, B.; Srihari, P.; Stereoselective Total Synthesis of the Marine Macrolide Sanctolide A; European Journal of Organic Chemistry; 2015; 2015(26); 5856-5863

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Synthesis of the Tetrasaccharide Repeating Unit of the β-Kdo-Containing Exopolysaccharide


Laroussarie, A.; Barycza, B.; Andriamboavonjy, H.; Kenfack, M. T.; Blériot, Y.; Gauthier, C.; Synthesis of the Tetrasaccharide Repeating Unit of the β-Kdo-Containing Exopolysaccharide from Burkholderia pseudomallei and B. cepacia Complex; The Journal of Organic Chemistry; 2015; 80(20); 10386-10396

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Continuous Reductive Amination of Biomass-Derived Molecules over Carbonized Filter Paper-Supported FeNi Alloy

Chieffi, G.; Braun, M.; Esposito, D.; Continuous Reductive Amination of Biomass-Derived Molecules over Carbonized Filter Paper-Supported FeNi Alloy; ChemSusChem; 2015; 8(21); 3590-3594

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Synergistic Interaction within Bifunctional Ruthenium Nanoparticle, Selective Hydrodeoxygenation of Phenols

Luska, L. K.; Migowski, P.; Sayed, E. S.; Leitner, W.; Synergistic Interaction within Bifunctional Ruthenium Nanoparticle/SILP Catalysts for the Selective Hydrodeoxygenation of Phenols; Angewandte Chemie; 2015; 127(52); 15976-15981

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Continuous-flow biochemical reactors, utilizing immobilized microfluidic enzyme reactors

Hajba, L.; Guttman, A.;Continuous-flow biochemical reactors: Biocatalysis, bioconversion, and bioanalytical applications utilizing immobilized microfluidic enzyme reactors; Journal of flow chemistry; 2016; 6(1); 8-12

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Chapter Two – Flow Synthesis of Heterocycles

Movsisyan, M.; Moens, M. M.; Stevens, C. V.; Chapter Two - Flow Synthesis of Heterocycles; Advances in Heterocyclic Chemistry; 2016; 119; 25-55

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Diversity-Oriented Synthesis of a Library of Star-Shaped 2H‑Imidazolines

Yu, X.; Guttenberger, N.; Fuchs, E.; Peters, M.; Weber, H.; Breinbauer R.; Diversity-Oriented Synthesis of a Library of Star-Shaped
2H‑Imidazolines; ACS Combinatorial Science; 2015; 17(11); 682-690

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An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor

Russell, C.; Lin, A. J. S.; Hains, P.; Simone, M. I.; Robinson, P. J.; McCluskey, A.; An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor; RSC Advances; 2015; 5; 93433-93437

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Continuous flow hydrogenation of nitroarenes, azides and alkenes using maghemite-Pd nanocomposites

Rathi, A. K.; Gawande, M. B.; Ranc, V.; Pechousek, J.; Petr, M.; Cepe, K.; Varma, R. S.; Zboril, R.; Continuous flow hydrogenation of nitroarenes, azides and alkenes using maghemite-Pd nanocomposites; Catalysis Science & Technology; 2015; 6, 152-160

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Diels-Alder Reaction of 1,3-Diene-1-carbamates Catalyzed by Chiral Phosphoric Acids

Pous, J.; Courant, T.; Bernadat, G.; Iorga, B. I.; Blanchard, F.; Masson, G.; Regio-, Diastereo-, and Enantioselective Nitroso-Diels-Alder Reaction of 1,3-Diene-1-carbamates Catalyzed by Chiral Phosphoric Acids; Journal of the American Chemical Society; 2015; 137 (37); 11950-11953

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Improved and scalable synthesis of building blocks for the modular synthesis of teraryl-based alpha-helix mimetics

Trobe, M.; Breinbauer, R.; Improved and scalable synthesis of building blocks for the modular synthesis of teraryl-based alpha-helix mimetics; Monatsh Chem; 2015; 147 (3); 509-521

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Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents

Ng, P. S.;Manjunatha, U. H.; Rao, S. P. S.; Camacho, L. R.; Ma, N. L.; Herve, M.; Noble, C. G.; Goh, A.; Peukert, S.; Diagana, T. T.; Smith, P. W.; Kondreddi, R. R.; Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents; European Journal of Medicinal Chemistry; 2015; 106; 144-156

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1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activity


Abdel-Hamid, M. K.; Macgregor, K. A.; Odell, L. R.; Chau, N.; Mariana, A.; Whiting, A.; Robinson, P. J.; McCluskey, A.; 1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activity; Organic & Biomolecular Chemistry; 2015; 13(29); 8016-8028

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Synthesis of the Trisaccharide Repeating Unit of the Lipopolysaccharide from Moritella viscosa Strain M2-226

Pal, K. B.; Verma, P. R.; Gupta, T.; Mukhopadhyay, B.; Synthesis of the Trisaccharide Repeating Unit of the Lipopolysaccharide from Moritella viscosa Strain M2-226; Journal of Carbohydrate Chemistry; 2015; 34(4); 173-182

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Molecularly imprinted polymers for leanup and selective extraction of curcuminoids in medicinal herbal extracts

Wulandari, M.; Urraca, J. L.; Descalzo, A. B.; Amran, M. B.; Moreno-Bondi, M. C.; Molecularly imprinted polymers for leanup and selective extraction of curcuminoids in medicinal herbal extracts; Analytical and Bioanalytical Chemistry; 2015; 407(3); 803-812

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Synthesis of 13C Labeled Complex N-Glycans As Internal Standards for the Absolute Glycan Quantification by MS

Echeverria, B.; Etxebarria, J.; Ruiz, N.; Hernandez, A.; Calvo, J.; Haberger, M.; Reusch, D.; Reichardt, N-C.; Chemo-Enzymatic Synthesis of 13C Labeled Complex N-Glycans As Internal Standards for the Absolute Glycan Quantification by Mass Spectrometry; Analytical Chemistry; 2015; 87(22); 11460-11467

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One-pot reductive amination of aldehydes with nitroarenes over an Au/Al2O3 catalyst in a continuous flow reactor

Artiukha, E. A.; Nuzhdin, A. L.; Bukhtiyarova, G. A.; Zaytsev, S. Yu.; Plyusnin, P. E.; Shubinbc, Yu. V.; Bukhtiyarov, V. I.; One-pot reductive amination of aldehydes with nitroarenes over an Au/Al2O3 catalyst in a continuous flow reactor; The Royal Society of Chemistry; 2015; 5(10); 4741-4745

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Densely Substituted l-Proline Esters as Catalysts for Asymmetric Michael Additions of Ketones to Nitroalkenes

Ruiz-Olalla, A.; de Gracia Retamosa, M.; Cossío, F. P.; Densely Substituted l-Proline Esters as Catalysts for Asymmetric Michael Additions of Ketones to Nitroalkenes; J. Org. Chem.; 2015; 80 (11); 5588-5599

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Continuous-flow hydrogenation of olefins and nitrobenzenes catalyzed by platinum nanoparticles

Osako, T.; Torii, K.; Tazawaa, A.; Uozumi, Y.; Continuous-flow hydrogenation of olefins and nitrobenzenes catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer; RSC Adv.; 2015; 5; 45760-45766

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Structure and Reactivity of Supported Hybrid Platinum Nanoparticles for the Flow Hydrogenation of Functionalized Nitroaromatics

Vilé, G.; Almora-Barrios, N.; López, N.; Pérez-Ramírez, J.; Structure and Reactivity of Supported Hybrid Platinum Nanoparticles for the Flow Hydrogenation of Functionalized Nitroaromatics; ACS Catal.; 2015; 5(6); 3767-3778

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Molecularly imprinted hydrogels as functional active packaging materials

Benito-Pena, E.; González-Vallejo, V.; Rico-Yuste, A.; Barbosa-Pereira, L.; Cruz, J. M.; Bilbao, A.; Alvarez-Lorenzo, C.; Moreno-Bondi, M. C.; Molecularly imprinted hydrogels as functional active packaging materials; Food Chemistry; 2016; 190; 487-494

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Synthesis of Benzannulated Spiroketals Using an Oxidative Radical Cyclization

Sperry, J.; Liu, Y-C.; Wilson, Z. E.; Hubert, J. G.; Brimble, M. A.; Synthesis of Benzannulated Spiroketals Using an Oxidative Radical Cyclization; Synthesis, 2011; 9; 1383-1398

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Nanotechnology tools in pharmaceutical R&D

Kumar, C. S.S.R.; Nanotechnology tools in pharmaceutical R&D; Materials Today; 2010, 12; 24-30

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Synthesis of a Streptococcus pyogenes candidate based on the M protein PL1 epitope

Simerska, P.; Lu, H.; Toth, I.; Synthesis of a Streptococcus pyogenes candidate based on the M protein PL1 epitope; Bioorganic & Medicinal Chemistry Letters; 2009; 19(3); 821-824

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Facile Conversion of Red Phosphorus into Soluble Polyphosphide Anions by Reaction with Potassium Ethoxide

Dragulescu-Andrasi, A.; Miller, L. Z.; Chen, B.; McQuade, D. T.; Shatruk M.; Facile Conversion of Red Phosphorus into Soluble Polyphosphide Anions by Reaction with Potassium Ethoxide; Angewandte Chem.; 2016; 55(12); 3904-3908

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Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification

Ouchi, T.; Mutton, R. J.; Rojas, V.; Fitzpatrick, D. E.; Cork, D. G.; Battilocchio, C.; Ley, S. V.; Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification; ACS Sustainable Chem.&Eng.; 2016; 4(4); 1912-1916

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A continuous flow process for the green and sustainable production of N-alkyl imidazoles

Fekete, M.; Kocsis L.; Dormán, Gy.; Darvas, F.; A continuous flow process for the green and sustainable production of N-alkyl imidazoles; Green Processing and Synthesis; 2016; 5(3); 239-246

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High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences

Bogdan, R. A.; Charaschanya, M.; Dombrowski, A. W.; Wang, Y.; Djuric, S. W.; High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences; Org. Lett.; 2016; 18(8), 1732-1735

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Nucleophilic aromatic substitution of heterocycles using a high-temperature and high-pressure flow reactor

Charaschanya, M.; Bogdan, A. R.; Wang, Y.; Djuric, S. W.; Nucleophilic aromatic substitution of heterocycles using
a high-temperature and high-pressure flow reactor; Tetrahedron Letters; 2016; 57(9); 1035-1039

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Chemical Synthesis of the Pentasaccharide Related to the Repeating Unit of the O-Antigen from Salmonella enterica O4

Das, R.; Mukhopadhyay, B.; Chemical Synthesis of the Pentasaccharide Related to the Repeating Unit of the O-Antigen from Salmonella enterica O4; Journal of Carbohydrate Chemistry; 2015; 34(5); 247-262

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Catalytic Epoxidation of Cyclohexene with Tert-butylhydroperoxide Using an Immobilized Molybdenum Catalyst

Morales-delaRosa, S.; Campos-Martin, J. M.; Terreros, P.; Fierro, J. L. G.; Catalytic Epoxidation of Cyclohexene with Tert-butylhydroperoxide Using an Immobilized Molybdenum Catalyst; Topics in Catalysis; 2015; 58(4); 325-333

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Research spotlight: Microwave chemistry enabling the synthesis of biologically relevant amines

Spencer, J.; Research spotlight: Microwave chemistry enabling the synthesis of biologically relevant amines; Future Med. Chem; 2010; 2(2); 161-168

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Heterogeneous catalytic synthesis using microreactor technology

Frost, C. G.; Mutton, L.; Heterogeneous catalytic synthesis using microreactor technology; Green Chem.; 2010; 12; 1687-1703

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Microwave-Assisted Carbonylation and Cyclocarbonylation of Aryl Iodides under Ligand Free Heterogeneous Catalysis

Salvadori, J.; Balducci, E.; Zaza, S.; Petricci, E.; Taddei, M.; Microwave-Assisted Carbonylation and Cyclocarbonylation of Aryl Iodides under Ligand Free Heterogeneous Catalysis; J. Org. Chem.; 2010; 75(6); 1841-1847

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The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors

Carter, C. F.; Baxendale, I. R.; Pavey, J. B. J.; Ley, S. V.; The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors; Org. Biomol. Chem.; 2010; 8; 1588-1595

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The development of poly(dendrimer)s for advanced processing

Gunning, J. P.; Levell, J. W.; Wyatt, M. F.; Burn, P. L.; Robertson, J.; Samuel, I. D. W.; The development of poly(dendrimer)s for advanced processing; Polym. Chem.; 2010; 1; 730-738

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Interaction of β-Cyclodextrin with DNA-Bases

Liedl, E.; Beyer, A.; Wolschann, P.; Vierstein, H.; Interaction of β-Cyclodextrin with DNA-Bases; Sci Pharm.; 2010; 78(3); 590

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Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary

Jones, A. L.; Liu, X.; Snyder, J. K.; Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary; Tetrahedron Lett.; 2010; 51(7); 1091-1094

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Microreactor Technology as an Efficient Tool for Multicomponent Reactions

Cukalovic, A.; Monbaliu, J. M. R.; Stevens, C. V.; Microreactor Technology as an Efficient Tool for Multicomponent Reactions; Top.Heterocycl.Chem.; 2010; 23; 161-198

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4-C-Methyl-2-Deoxyadenosine and 4-C-Ethyl-2-Deoxyadenosine Inhibit HIV-1 Replication

Vu, B. C.; Boyer, P. L.; Siddiqui, M. A.; Marquez, V. E.; Hughes, S. H.; 4'-C-Methyl-2'-Deoxyadenosine and 4'-C-Ethyl-2'-Deoxyadenosine Inhibit HIV-1 Replication; Antimicrob.Agents&Chemother.; 2011; 55(5); 2379-2389

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Microwave-Assisted Grafting to MCM-41 Silica and its Application as Catalyst in Flow Chemistry

Oliverio, M.; Procopio, A.; Glasnov, T. N.; Goessler, W.; Kappe, C. O.; Microwave-Assisted Grafting to MCM-41 Silica and its Application as Catalyst in Flow Chemistry; Aust.J.Chem.; 2011; 64; 1522-1529

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Hydrogenation of Binary Mixtures of Activated Ketones on Pt-Alumina and on Pt-Alumina-Cinchonidine Catalysts

SzÅ‘llÅ‘si, Gy.; Makra, Zs.; Fülöp, F.; Bartók, M.; The First Case of Competitive Heterogeneously Catalyzed Hydrogenation using Continuous-Flow Fixed-Bed Reactor System: Hydrogenation of Binary Mixtures of Activated Ketones on Pt-Alumina and on Pt-Alumina-Cinchonidine Catalysts; Catalysis Letters; 2011; 141; 1616-1620

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Diastereoselective Chain-Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly

Carter, C.F.; Lange, H.; Sakai, D.; Baxendale I.R.; Ley, S.V.; Diastereoselective Chain-Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly; Chem. Eur. J.; 2011; 17; 3398-3405

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A Two-Step Continuous-Flow Synthesis of N-(2-Aminoethyl)acylamides through Ring-Opening/Hydrogenation of Oxazolines

Gutmann, B.; Roduit, J.P.; Roberge, D.; Kappe, C.O.; A Two-Step Continuous-Flow Synthesis of N-(2-Aminoethyl)acylamides through Ring-Opening/Hydrogenation of Oxazolines; Chem. Eur. J.; 2011; 17; 13146 - 13150

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Cross-coupling in flow

Noel, T.; Buchwald, S.L.; Cross-coupling in flow; Chem. Soc. Rev.; 2011; 40; 5010-5029

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Stereoselective approaches to 2,3,6-trisubstituted piperidines. An enantiospecific synthesis of quinolizidine ( )-217A

Mancey, N.C.; Sandon, N.; Auvinet, A.L.; Butlin, R.J.; Czechtizky, W.; Harrity, J.P.A.; Stereoselective approaches to 2,3,6-trisubstituted piperidines. An enantiospecific synthesis of quinolizidine ( )-217A; Chem. Commun.; 2011; 47; 9804-9806

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A simple chemical model for clathrate hydrate inhibition by polyvinylcaprolactam

Davenport, J.R.; Musa, O.M.; Paterson, M.J.; Piepenbrock, M.O.M.; Fucke, K.; Steed, J.W.; A simple chemical model for clathrate hydrate inhibition by polyvinylcaprolactam; Chem. Commun.; 2011; 47; 9891-9893

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Synthesis of 5-Bromomethylfurfural from Cellulose as a Potential Intermediate for Biofuel

Kumari, N.; Olesen, J.K.; Pedersen, C.M.; Bols, M.; Synthesis of 5-Bromomethylfurfural from Cellulose as a Potential Intermediate
for Biofuel; Eur. J. Org. Chem.; 2011; 2011(7); 1266-1270

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Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences

Baumann, M.; Baxendale, I.R.; Kirschning, A.; Ley, S.V.; Wegner, J.; Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor; Heterocycles; 2011; 82(2); 1297-1316

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The Evaluation of a β-(1,3) Glucan Hexasaccaride-CRM197 Conjugate as Vaccine Candidate against Candida albicans

Danieli, E.; Proietti, D.; Berti, F.; Constantino, P.; Synthesis of Laminarin Fragments and Evaluation of a β-(1,3) Glucan Hexasaccaride-CRM197 Conjugate as Vaccine Candidate against Candida albicans; Journal of Carbohydrate Chemsitry; 2011; 30; 249-280

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Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents

Coteron, J.M.; Marco, M.; Esquivias, J.; Deng, X.; White, K.L; White, J.; Koltun, M.; Mazouni, F.E.; Kokkonda, S.; Katneni, K.; Bhamidipati, R.; Shackleford, D.M.; Angulo-Barturen, I.; Ferrer, S.B.; Jiménez-Díaz, M.B.; Gamo, F.J.; Goldasmith, E.J.; Charman, W.N.; Bathurst, I.; Floyd, D.; Matthews, D.; Burrows, J.N.; Rathod, P.K.; Charman, S.A.; Philips, M.A; Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential; J. Med. Chem.; 2011; 54(15); 5540-5561

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Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase

Charrier, J.D.; Durrant, S.J.; Golec, J.M.; Kay, D.P., Knegtel, R.M.A.; MacCormick, S.; Mortimore, M.; O'Donnell, M.E.; Pinder, J.L.; Reaper, P.M.; Rutherford, A.P.; Wang, P.S.H.; Young, S.C.; Pollard, J.R.; Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents; J. Med. Chem.; 2011; 54(7); 2320-2330

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The flow synthesis of heterocycles for natural product and medicinal chemistry applications

Baumann, M.; Baxendale, I.R.; Ley, S.v.; The flow synthesis of heterocycles for natural product and medicinal chemistry applications; Molecular Diversity; 2011; 15(3); 613-630

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Hydrothermal formose reaction

Kopetzki, D.; Antonietti, M.; Hydrothermal formose reaction; New J. Chem.; 2011; 35; 1787-1794

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Synthesis of spirocyclic thiazolidinediones using ring-closing metathesis and one-pot sequential ring-closing/cross metathesis

Dhara, K.; Paladhi, S.; Midya, G.C.; Dash, J.; Synthesis of spirocyclic thiazolidinediones using ring-closing metathesis and one-pot sequential ring-closing/cross metathesis; Org. Biomol. Chem.; 2011; 9; 3801-3807

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Synthesis of N-propynyl analogues of peptide nucleic acid (PNA) monomers and their use in a click reaction

Howarth, N.M.; Ricci, J.; Synthesis of N-propynyl analogues of peptide nucleic acid (PNA) monomers and their use in the click reaction to prepare N-functionalized PNAs; Tetrahedron; 2011; 67; 9588-9594

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A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core

Hay, D.A.; Adam, F.M.; Bish, G.; Calo, F.; Dixon, R.; Fray, M.J.; Hitchin, J.; Jones, P.; Paradowski, M.; Parsons, G.C.; Proctor, K.J.W.; Pryde, D.C.; Smith, N.N.; Tran, T.D.; A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core; Tetrahedron Letters, 2011, 52(44); 5728-5732

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Flow Chemistry – A Key Enabling Technology for (Multistep) Organic Synthesis

Wegner, J.; Ceylan, S.; Kirschning, A.; Flow Chemistry - A Key Enabling Technology for (Multistep) Organic Synthesis; Adv. Synth. Catal.; 2012; 354; 17-57

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Continuous-Flow Processes in Heterogeneously Catalyzed Transformations of Biomass Derivatives into Fuels and Chemicals

Serrano-Ruiz, J.C.; Luque, R.; Campelo, J.M.; Romero, A.A.; Continuous-Flow Processes in Heterogeneously Catalyzed Transformations of Biomass Derivatives into Fuels and Chemicals; Challenges; 2012; 3; 114-132

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Microwave-assisted synthesis of medium-sized heterocycles

Sharma, A.; Appukkuttan, P.; Van der Eycken, E.; Microwave-assisted synthesis of medium-sized heterocycles; Chem. Commun.; 2012; 48; 1623-1637

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Application of Metal-Based Reagents and Catalysts in Microstructured Flow Devices

Chinnusamy, T.; Yudha S.S.; Hager, M.; Kreitmeier, P.; Reisen, O.; Application of Metal-Based Reagents and Catalysts in Microstructured Flow Devices; ChemSusChem; 2012; 5(2); 247-255

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Synthesis and anticancer activity of a series of norcantharidin analogues

Tarleton, M.; Gilbert, J.; Sakoff, J.A.; McCluskey, A.; Synthesis and anticancer activity of a series of norcantharidin analogues; European Journal of Medicinal Chemistry; 2012; 54; 573-581

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Continuous flow reactors: a perspective

Wiles, C.; Watts, P.; Continuous flow reactors: a perspective; Green Chem.; 2012; 14; 38-54

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Catalysis in flow: Au-catalysed alkylation of amines by alcohols

Zotova, N.; Robert, F.J.; Kelsall, G.H.; Jessiman, A.S.; Hellgardt, K.; Hii, K.K.; Catalysis in flow: Au-catalysed alkylation of amines by alcohols; Green Chem.; 2012; 14; 226-232

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Versatile dual hydrogenation-oxidation nanocatalysts for the aqueous transformation of biomass-derived platform molecules

García-Suárez, E.J.; Balu A.M.; Tristany, M.; García, A.B.; Philippot, K.; Lugue, R.; Versatile dual hydrogenation-oxidation nanocatalysts for the aqueous transformation of biomass-derived platform molecules; Green Chem.; 2012; 14; 1434-1439

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Methylation using dimethylcarbonate catalysed by ionic liquids under continuous flow conditions

Glasnov, T.N.; Holbrey, J.D.; Kappe, C.O.; Seddon, K.R.; Yan, T.; Methylation using dimethylcarbonate catalysed by ionic liquids under continuous flow conditions; Green Chem.; 2012; 14; 3071-3076

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Micro reactors, flow reactors and continuous flow synthesis

Watts, P.; Wiles, C.; Micro reactors, flow reactors and continuous flow synthesis; Journal of Chemical Research; 2012; 36; 181-193

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Safe Generation and Synthetic Utilization of Hydrazoic Acid in a Continuous Flow Reactor

Gutmann, B.; Obermayer, D.; Roduit, J.P.; Roberge, D.M.; Kappe, C.O.; Safe Generation and Synthetic Utilization of Hydrazoic Acid in a Continuous Flow Reactor; Journal of Flow Chemistry; 2012; 2(1); 8-19

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User Friendly and Flexible Kiliani Reaction on Ketoses Using Microreaction Technology

Cukalovic, A.; Monbaliu, J.C.M.; Heynderickx, G.J.; Stevens, C.V.; User Friendly and Flexible Kiliani Reaction on Ketoses Using Microreaction Technology; Journal of Flow Chemistry; 2012; 2(2); 43-46

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Flash Flow Pyrolysis: Mimicking Flash Vacuum Pyrolysis in a High-Temperature/High-Pressure Liquid-Phase Microreactor Environmen

Cantillo, D.; Sheibani, H.; Kappe, C.O.; Flash Flow Pyrolysis: Mimicking Flash Vacuum Pyrolysis in a High-Temperature/High-Pressure Liquid-Phase Microreactor Environment; J. Org. Chem.; 2012; 77 (5); 2463-2473

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Rapid synthesis of substituted pyrrolines and pyrrolidines by nucleophilic ring closure at activated oximes

Chandan, N.; Thompson, A.; Moloney, M.G.; Rapid synthesis of substituted pyrrolines and pyrrolidines by nucleophilic ring closure at activated oximes; Org. Biomol. Chem.; 2012; 10; 7863-7868

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Fragment-Hopping-Based Discovery of a Novel Chemical Series of Proto-Oncogene PIM-1 Kinase Inhibitors

Saluste, G.; Albarran, M.I.; Alvarez, R.M.; Rabal, O.; Ortega, M.A.; Blanco, C.; Kurz, G.; Salgado, A.; Pevarello, P.; Bischoff, J.R.; Pastor, J.; Oyarzabal, J.; Fragment-Hopping-Based Discovery of a Novel Chemical Series of Proto-Oncogene PIM-1 Kinase Inhibitors; PLoS One; 2012; 7(10); e45964

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Investigation, optimization and synthesis of sulfamoyloxy-linked aminoacyl-AMP analogues

Redwan, I.N.; Ljungdahl, T.; Grøtli, M.; Investigation, optimization and synthesis of sulfamoyloxy-linked aminoacyl-AMP analogues; Tetrahedron; 2012; 68(5); 1507-1514

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Total synthesis of (±)-monomorine

Le, T.Q.; Oliver, R.M.; Arcari, J.T.; Mitton-Fry, M.J.; Total synthesis of (±)-monomorine; Tetrahedron Letters; 2012; 53(42); 5660-5662

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Disubstituted 1-Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design and High-Throughput Batch

Bryan, M.C.; Hein, C.D.; Gao, H.; Xia, X.; Eastwood, H.; Bruenner, B.A.; Louie, S.W.; Doherty, E.M; Disubstituted 1-Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design and High-Throughput Batch and Flow Technologies; ACS Comb. Sci.; 2013; 15 (9); 503-511

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Application of Factorial Design of Experiments for the Continuous Hydrogenation of Enriched Castor Oil Methyl Esters

Neeharika, T.S.V.R.; Rani, K.N.P.; Rao, K.V.S.A.; Kumar, T.P.; Prasad, R.B.N.; Application of Factorial Design of Experiments for the Continuous Hydrogenation of Enriched Castor Oil Methyl Esters; Bulletin of Chemical Reaction Engineering & Catalysis; 2013; 8 (2); 154-159

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Continuous flow nanocatalysis: reaction pathways in the conversion of levulinic acid to valuable chemicals

Bermudez, J.M.; Menéndez, J.A.; Romero, A.A.; Serrano, E.; Garcia-Martinez, J.; Lugue, R.; Continuous flow nanocatalysis: reaction pathways in the conversion of levulinic acid to valuable chemicals; Green Chem.; 2013; 15(10); 2786-2792

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Enantioselective access to benzannulated spiroketals using a chiral sulfoxide auxiliary

Aitken, H.R.M.; Furkert, D.P.; Hubert, J.G.; Wood, J.M.; Brimble, M.A.; Enantioselective access to benzannulated spiroketals using a chiral sulfoxide auxiliary; Org. Biomol. Chem.; 2013; 11; 5147-5155

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Concise synthesis of the trisaccharide repeating unit of the O-polysaccharide from Aeromonas hydrophila A19 (O:14)

Pal, K.B.; Mukhopadhyay, B.; Concise synthesis of the trisaccharide repeating unit of the O-polysaccharide from Aeromonas hydrophila A19 (O:14); Carbohydrate Research; 2013; 379; 26-29

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Flow Chemistry Syntheses of Natural Products

Pastre, J.C.; Browne, D.L.; Ley, S.V.; Flow Chemistry Syntheses of Natural Products; Chem. Soc. Rev.; 2013; 42; 8849-8869

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Self-assembly of a helical zinc-europium complex: speciation in aqueous solution and luminescence

Deiters, E.; Eliseeva, S.V.; Bünzil, J.C.G.; Self-assembly of a helical zinc-europium complex: speciation in aqueous solution and luminescence; Front. Chem.; 2013; 1(15); 1-14

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Highly efficient iron(0) nanoparticle-catalyzed hydrogenation in water in flow

Hudson, R.; Hamasaka, G.; Osako, T.; Yamada, Y.M.A.; Li, C.J.; Uozumi, Y.; Moores, A.; Highly efficient iron(0) nanoparticle-catalyzed hydrogenation in water in flow; Green Chem.; 2013; 15; 2141-2148

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Flow chemistry approaches directed at improving chemical synthesis

Baxendale, I.R.; Brocken, L.; Mallia, C.J.; Flow chemistry approaches directed at improving chemical synthesis; Green Process. Synth.; 2013; 2(3) ; 211-230

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The integration of flow reactors into synthetic organic chemistry

Baxendale, I.R.; The integration of flow reactors into synthetic organic chemistry; J. Chem. Technol. Biotechnol.; 2013; 88; 519-552

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Studies of long chain lipids in insects by high temperature gas chromatography and high temperature GC-MS

Sutton, P.A.; Wilde, M.J.; Martin, S.J.; Cvačka, J.; Vrkoslav, V.; Rowland, S.J.; Studies of long chain lipids in insects by high temperature gas chromatography and high temperature gas chromatography-mass spectrometry; Journal of Chromatography A; 2013; 1297; 236-240

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VUT-MK142 : a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes

Koley, M.; Mike, A.K.; Heher, P.; Koenig, X.; Schön, M.; Schnürch, M.; Hilber, K.; Weitzer, G.; Mihovilovic, M.D.; VUT-MK142 : a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes; Med. Chem. Commun.; 2013; 4; 1189-1195

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A Continuous-Flow Microwave Reactor for Conducting High-Temperature and High-Pressure Chemical Reactions

Sauks, J. M.; Mallik, D.; Lawryshyn, Y.; Bender, T.; Organ, M.; A Continuous-Flow Microwave Reactor for Conducting High-Temperature and High-Pressure Chemical Reactions; Org. Process Res. Dev.; 2014; 18 (11); 1310-1314

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Versatile low-loaded mechanochemically synthesized supported iron oxide nanoparticles for continuous flow alkylations

Balu, A. M.; Pineda, A.; Obermayer, D.; Romero, A. A., Kappe, C. O.; Luque, R.; Versatile low-loaded mechanochemically synthesized supported iron oxide nanoparticles for continuous flow alkylations; RSC Adv.; 2013; 3; 16292-16295

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Synthesis of dual action cyclo-RGD/SMAC mimetic conjugates targeting αvβ3/αvβ5 integrins and IAP proteins

Mingozzi, M.; Manzoni, L.; Arosio, D.; Corso, A. D.; Manzotti, M.; Innamorati, F.; Pignataro, L.; Lecis, D.; Delia, D.; Seneci, P.; Gennari, C.; Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting αvβ3/αvβ5 integrins and IAP proteins; Org. Biomol. Chem.; 2014; 12; 3288-3302

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Synthesis of two trisaccharides related to the hepatoprotective phenylethanoids leonoside E and F

Budhadev, D.; Mukhopadhyay, B.; Synthesis of two trisaccharides related to the hepatoprotective phenylethanoids leonoside E and F isolated from Leonurus japonicus Houtt; Carbohydrate Research; 2014; 384; 51-55

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Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties against HIV-1

Flores, A.; Camarasa, M. J.; Pérez-Pérez, M. J.; San- Félix, A.; Balzarini, J.; Quesada, E.; Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties as novel synthetic polyphenols directed against HIV-1; Org. Biomol. Chem.; 2014; 12; 5278-5294

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Present and Future of Cyclopropanations in Fragrance Chemistry

Schröder, F.; Present and Future of Cyclopropanations in Fragrance Chemistry; Chemistry & Biodiversity; 2014; 11(11); 1734-1751

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Tetrahydroisoquinolinone-based Steroidomimetic and Chimeric Microtubule Disruptors

Leese, M. P.; Jourdan, F. L.; Major, M. R.; Dohle, W.; Hamel, E.; Ferrandis, E.; Fiore, A.; Kasprzyk, P. G.; Potter, B. V. L.; Tetrahydroisoquinolinone-based Steroidomimetic and Chimeric Microtubule Disruptors; ChemMedChem.; 2014; 9(1); 85-108

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Epoxy Resin Monomers with Reduced Skin Sensitizing Potency

O'Boyle, N. M.; Niklasson, I. B.; Tehrani-Bagha, A. R.; Delaine, T.; Holmberg, K.; Luthman, K.; Karlberg, A. T.; Epoxy Resin Monomers with Reduced Skin Sensitizing Potency; Chem. Res. Toxicol.; 2014; 27(6); 1002-1010

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A continuous process for glyoxal valorisation using tailored Lewis-acid zeolite catalysts

Dapsens, P. Y.; Mondelli, C.; Kusema, B. T.; Verel, R., Pérez-Ramírez, J.; A continuous process for glyoxal valorisation using tailored Lewis-acid zeolite catalysts; Green Chem.; 2014; 16; 1176-1186

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Evaluation of SILP-Pd catalysts for Heck reactions in amicrofluidics-based high throughput flow reactor

Urbán, B.; Srankó, D.; Sáfrán, Gy.; Ürge, L.; Darvas, F.; Bakos, J.; Skoda-Földes, R.; Evaluation of SILP-Pd catalysts for Heck reactions in amicrofluidics-based high throughput flow reactor; Journal of Molecular Catalysis A: Chemical; 2014; 395; 364-372

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Aziridine Ring Opening for the Synthesis of Sphingolipid Analogues: Inhibitors of Sphingolipid-Metabolizing Enzymes

Alcaide, A.; Llebaria, A.; Aziridine Ring Opening for the Synthesis of Sphingolipid Analogues: Inhibitors of Sphingolipid-Metabolizing Enzymes; J. Org. Chem.; 2014; 79(7); 2993-3029

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Intramolecular Aglycon Delivery Enables the Synthesis of 6-Deoxy-β-D-manno-heptosides as Fragments of Burkholderia…

Kenfack, M. T.; Blériot, Y.; Gauthier, C.; Intramolecular Aglycon Delivery Enables the Synthesis of 6-Deoxy-β-D-manno-heptosides as Fragments of Burkholderia pseudomallei and Burkholderia mallei Capsular Polysaccharide; J. Org. Chem.; 2014; 79(10); 4615-4634

A novel aminothiazole KY-05009 with potential to inhibit TNIK attenuates TGF-β1-mediated epithelial-to-mesenchymal transition

Kim, J.; Moon, S. H.; Kim, B. T.; Chae, C. H.; Lee, J. Y.; Kim, S. H.;A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells; PLoS One; 2014; 9(10); e110180

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Tools for chemical synthesis in microsystems

Jensen, K. F.; Reizman, B. J.; Newman, S. G.; Tools for chemical synthesis in microsystems; Lab. Chip; 2014; 14; 3206-3212 

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Synthesis and Stability Evaluation of New HYNIC Derivatives as Ligands for Technetium-99m

Joyard, Y.; Bischoff, L.; Levacher, V.; Papamicaël, C.; Vera, P.; Bohn, P.; Synthesis and Stability Evaluation of New HYNIC Derivatives as Ligands for Technetium-99m;  Letters in Organic Chemistry; 2014; 11(3); 208-214

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Isolation and Characterization of Anti-Adenoviral Secondary Metabolites from Marine Actinobacteria

Strand, M.; Carlssom, M.; Uvell, H.; Islam, K.; Edlund, K.; Cullman, I.; Altermark, B.; Mei, Y. F.; Elofsson, M.; Willassen, N. P.; Wadell, G.; Almqvist, F.; Isolation and Characterization of Anti-Adenoviral Secondary Metabolites from Marine Actinobacteria; Marine Drugs; 2014; 12(2); 799-821

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Discovery of acrylonitrile-based small molecules active against Haemonchus contortus

Gordon, C. P.; Hizartzidis, L.; Tarleton, M.; Sakoff, J. A.; Gilbert, J.; Campbell, B. E.; Gasser, R. B.; McCluskey, A.; Discovery of acrylonitrile-based small molecules active against Haemonchus contortus; Med. Chem. Commun.; 2014; 5; 159-164

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Evaluation of functional groups as acetyl-lysine mimetics for BET bromodomain inhibition

Sharp, P. P.; Garnier,  J. M.; Huang, D. C.; Burns, C. J.;  Evaluation of functional groups as acetyl-lysine mimetics for BET bromodomain inhibition; Med. Chem. Commun.; 2014; 5; 1834-1842

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Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling

Baer, S.; Nigro, J.; Madej, M. P.; Nisbet, R. M.; Suryadinata, R.; Coia, G.; Hong, L. P. T.; Adams, T. E.; Williams, C. C.; Nuttall, S. D.; Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling; Org. Biomol. Chem.; 2014; 12; 2675-2685

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Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting αvβ3/αvβ5 integrins

Mingozzi, M.; Manzoni, L.; Arosio, D.; Corso, A. D.; Manzotti, M.; Innamorati, F.; Pignataro, L.; Lecis, D.; Delia, D.; Seneci, P.;  Gennari, C.; Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting αvβ3/αvβ5 integrins and IAP proteins; Org. Biomol. Chem.; 2014; 12; 3288-3302

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Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

Gauthier, C.; Chassagne, P.; Theillet, F. X.; Guerreiro, C.; Thouron, F.; Nato, F.; Delepierre, M.; Sansonetti, P. J.; Phalipon, A.; Mulard, L. A.; Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity; Org. Biomol. Chem.; 2014; 12; 4218-4232

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An efficient continuous flow approach to furnish furan-based biaryls

Trinh, T. N.; Hizartzidis, L.; Lin, A. J. S.; Harman, D. G.; McCluskey, A.; Gordon, C. P.; An efficient continuous flow approach to furnish furan-based biaryls; Org. Biomol. Chem.; 2014; 12; 9562-9571

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Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control

Voltrova, S.; Srogl, J.; Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control; Org. Chem. Front.; 2014; 1; 1067-1071

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Sequential Nitration/Hydrogenation Protocol for the Synthesis of Triaminophloroglucinol

Cantillo, D.; Damm, M.; Dallinger, D.; Bauser, M.; Berger, M.; Kappe, C. O.; Sequential Nitration/Hydrogenation Protocol for the Synthesis of Triaminophloroglucinol: Safe Generation and Use of an Explosive Intermediate under Continuous-Flow Conditions; Org. Process Res. Dev.; 2014; 18(11); 1360-1366

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Design of Experiments (DoE) and Process Optimization. A Review of Recent Publications

Weissman, S. A.; Anderson, N. G.; Design of Experiments (DoE) and Process Optimization. A Review of Recent Publications; Org. Process Res. Dev.; 2015; 19(11); 1605-1633

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Two-dimensional GC/MS identification of bicyclic aromatic acids in petroleum fractions

West, C. E.; Pureveen, J.; Scarlett, A. G.; Lengger, S. K.; Wilde, M. J.; Korndorffer, F.; Tegelaar, E. W.; Rowland, S. J.; Can two-dimensional gas chromatography/mass spectrometric identification of bicyclic aromatic acids in petroleum fractions help to reveal further details of aromatic hydrocarbon biotransformation pathways?; Rapid Commun Mass Spectrom.; 2014; 28(9); 1023-1032

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Syntheses of 4-, 5-, 6-, and 7-substituted tryptamine derivatives and the use of a bromine atom as a protecting group

René, O.; Fauber, B. P.; Syntheses of 4-, 5-, 6-, and 7-substituted tryptamine derivatives and the use of a bromine atom as a protecting group; Tetrahedron Letters; 2014; 55(4); 830-833

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Formation of benzocyclobutenes from substituted oxocycloocta-2,8-diene-1,2-dicarboxylates

Bezenšek, j.; Grošelj, U.; Počkaj, M.; Svete, J.; Stanovnik, B.; Formation of benzocyclobutenes from substituted oxocycloocta-2,8-diene-1,2-dicarboxylates; Tetrahedron Letters; 2015; 56(42); 5705-5708

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Liquid phase oxidation chemistry in continuous-flow microreactors

Gemoets, H. P. L.; Su, Y.; Shang, M.; Hessel V.; Luque, R.; Noël, T.; Liquid phase oxidation chemistry in continuous-flow microreactors; Chem. Soc. Rev.; 2016; 45; 83-117

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Synthesis of four (4-, 2-, 2-, and 6-) monodeoxy analogs of the trisaccharide…

Glinschert, A.; Oscarson, S.; Synthesis of four (4"-, 2"-, 2'-, and 6-) monodeoxy analogs of the trisaccharide α-D-Glcp-(1→3)-α-d-Manp-(1→2)-α-D-ManpOMe recognized by Calreticulin/Calnexin; Carbohydrate Research; 2015; 414; 65-71

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Total Synthesis of (±)-Taiwaniaquinol F and Related Taiwaniaquinoids

Kakde, B. N.; Kumari, P.; Bisai, A.; Total Synthesis of (±)-Taiwaniaquinol F and Related Taiwaniaquinoids; J. Org. Chem.; 2015; 80(20); 9889-9899

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The Use of Gases in Flow Synthesis

Mallia, C. J.; Baxendale, I. R.; The Use of Gases in Flow Synthesis; Org. Process Res. Dev.; 2016; 20(2); 327-360

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Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

Phillipson, L. J.; Segal, D. H.; Nero, T. L.; Parker, M. W.; Wan, S. S.; Silva, M.d.; Guthridge, M. A.; Wei, A. H.; Burns, C. J.; Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9; Bioorganic & Medicinal Chemistry; 2015; 23(19); 6280-6296

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Taming hazardous chemistry by continuous flow technology

Movsisyan, M.; Delbeke, E. I. P.; Berton, J. K. E. T.; Battilocchio, C.; Ley, S. V.; Stevens, C. V.; Taming hazardous chemistry by continuous flow technology; Chem. Soc. Rev.; 2016; ??; ??

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Flow Chemistry: Intelligent Processing of Gas-Liquid Transformations Using a Tube-in-Tube Reactor

Brzozowski, M.; O’Brien, M.; Ley, V. S.;  Polyzos, A.; Flow Chemistry: Intelligent Processing of Gas-Liquid Transformations Using a Tube-in-Tube Reactor; Acc. Chem. Res.; 2015; 48(2); 349-362

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Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists

Savall, B. M.; Wu, D.; Angelis, M. D.; Carruhters, N. I.; Ao, H.; Wang, Q.; Lord, B.; Bharrachrya, A.; Letavic, M. A.; Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists; ACS Med. Chem. Lett.; 2015; 6; 671−676

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Organic Synthesis: March of the Machines

Ley, S. V.; Fitzpatrick, D. E.; Ingham, R. J.; Myers, R. M.; Organic Synthesis: March of the Machines; Angewandte Chemie; 2015; 54(11); 3449-3464

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One-pot tandem Suzuki cross coupling-reduction of haloacetophenones and arylboronic acids

Zhang, D.; Cheng, T.; Liu, G.; An imidazolium-based organopalladium-functionalized organic-inorganic hybrid silica promotes one-pot tandem Suzuki cross coupling-reduction of haloacetophenones and arylboronic acids; Applied Catal. B: Environmental; 2015 ; 174-175; 344-349

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The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

Baumann, M.; Baxendale, I. R.; The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry; Beilstein J. Org. Chem.; 2015; 11; 1194-1219

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Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators

Martín-Martín, M. L.; Bartolomé-Nebreda, J. M.; Conde-Ceide, S.; Alonso de Diego, S. A.; López, S.; Martínez-Viturro, C. M.; Tong, H. M.; Lavreysen, H.; Macdonald, G. J.; Steckler, T.; Mackie, C.; Bridges, T. M.; Daniels, J. S.; Niswender, C. M.; Noetzel, M.J.; Jones, C.K.; Conn, P. J.; Lindsley, C. W.; Stauffer, S. R.; Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5); Bioorg. Med. Chem. Lett.; 2015; 25(6); 1310-1317

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Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives

Bazin, H. G.; Li, Y.; Khalaf, J. K.; Mwakwari, S.; Livesay, M. T.; Evans, J. T.; Johnson, D. A.; Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives; Bioorganic & Medicinal Chemistry Letters; 2015; 25(6); 1318-1323

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The role of water in catalytic biomass-based technologies to produce chemicals and fuels

Mika, L. T.; Cséfalvay, E.; Horváth, I. T.; The role of water in catalytic biomass-based technologies to produce chemicals and fuels; Catalysis Today; 2015; 247; 33-46

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Application in the Michael Addition Sequence Towards 3-Arylated 4-Oxochromanes

Suljic´, S.; Mortzfeld, F. B.; Gunne, M.; Urlacher, V. B.; Pietruszka, J.; Enhanced Biocatalytic Performance of Bacterial Laccase from Streptomyces sviceus: Application in the Michael Addition Sequence Towards 3-Arylated 4-Oxochromanes; ChemCatChem; 2015; 7; 1380 -1385

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Solvent-free enzymatic process for biolubricant production in continuous microfluidic reactor

Madarász, J.; Németh, D.; Bakos, J.; Gubicza, L.; Bakonyi, P.; Solvent-free enzymatic process for biolubricant production in continuous microfluidic reactor; Journal of Cleaner Production; 2015; 93; 140-144

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Synthesis of N-Hydroxypyrazin-2(1H)-ones via Selective O-Debenzylation of 1-Benzyloxypyrazin-2(1H)-ones

Mai, A. H.; De Borggraeve, M.; Synthesis of N-Hydroxypyrazin-2(1H)-ones via Selective O-Debenzylation of 1-Benzyloxypyrazin-2(1H)-ones Using Flow Methodology; J. Flow Chem.; 2015; 5(1); 6-10

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A Flow-Based Synthesis of Telmisartan

Martin, A. D.; Siamaki, A. R.; Belecki, K.; Gupton, B. F.; A Flow-Based Synthesis of Telmisartan; J. Flow Chem.; 2015; 5(3); 145-147

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Mass Transfer Characteristics of Ozonolysis in Microreactors and Advanced-Flow Reactors

Nieves-Remacha, M. J.; Jensen, K. F.; Mass Transfer Characteristics of Ozonolysis in Microreactors and Advanced-Flow Reactors; J. Flow Chem.; 2015; 5(3); 160-165

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Synthesis and Biological Evaluation of Second-Generation Tropanol-Based Androgen Receptor Modulators

Sundén, H.; Holland, M. C.; Pouiainen, P. K.; Jääskeläinen, T.; Pulkkinen, J. T.; Palvimo, J. J.; Olsson, R.; Synthesis and Biological Evaluation of Second-Generation Tropanol-Based Androgen Receptor Modulators; J. Med. Chem.; 2015; 58; 1569−1574

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Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain

Parsons, W. H.; Calvo, R. R.; Cheung, W.; Lee, Y. K.; Patel, S.; Liu, J.; Youngman, M. A.; Dax, S. L.; Stone, D.; Qin, N.; Hutchinson, T.; Lubin, M. L.; Zhang, S. P.; Finley, M.; Liu, Y.; Brandt, M. R.; Flores, C. M.; Player, M. R.; Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep); J. Med. Chem.; 2015; 58 (9); 3859-3874

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Synthetic Studies toward the C32−C46 Segment of Hemicalide. Assignment of the Relative Configuration of the C36−C42 Subunit

Specklin, S.; Boissonnat, G.; Lecourt, C.; Sorin, G.; Lannou, M. I.; Ardisson, J.; Sautel, F.; Massiot, G.; Meyer, C.; Cossy, J.; Synthetic Studies toward the C32−C46 Segment of Hemicalide. Assignment of the Relative Configuration of the C36−C42 Subunit; Org. Lett.; 2015; 17(10); 2446−2449

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SiliaCat: A Versatile Catalyst Series for Synthetic Organic Chemistry

Ciriminna, R.; Pandarus, V.; Fidalgo, A.; Ilharco, L. M.; Béland, F.; Pagliaro, M.; SiliaCat: A Versatile Catalyst Series for Synthetic Organic Chemistry; Org. Process Res. Dev.; 2015; 19 (7); 755-768

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Continuous-flow catalytic hydrogenation of 3a,6-epoxyisoindoles

Zaytsev, V. P.; Zubkov, F. I.; Mertsalov, D. F.; Orlova, D. N.; Sorokina, E. A.; Nikitina, E. V.; Varlamov, A. V.; Continuous-flow catalytic hydrogenation of 3a,6-epoxyisoindoles; Russian Chemical Bulletin; 2015; 64(1); 112-126

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Safe hydrogenation of organic compounds and their property studies

Soung, M. J.; Woo, S. J.; Shin, D. J.; Safe hydrogenation of organic compounds and their property studies; Youth Scientist Journal; 2015; 7(1); 45-53

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Interesting applications on a novel high pressure high temperature microfluidic-based flow reactor

Niesz, K.; Csajagi, Cs.; Borcsek, B.; Jones, R. V.; Darvas, F.; Interesting applications on a novel high pressure high temperature microfluidic-based flow reactor; Nanotechnology; 2007; 4; 426-429

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Natural-product-like spiroketals and fused bicyclic acetals as therapeutic agents for leukaemia

Milroy, LG.; Zinzalla, G.; Loiseau, F.; Qian, Z.; Prencipe, G.; Pepper, C.; Fegan, C.; Ley, SV.; Natural-product-like spiroketals and fused bicyclic acetals as potential therapeutic agents for B-cell chronic lymphocytic leukaemia; ChemMedChem; 2008; 3; 1922-1935

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Using chemical probes to investigate the sub-inhibitory effects of azithromycin

Glansdorp, F. G.; Spandl, R. J.; Swatton, J. E.; Loiseleur, O.; Welch, M.; Spring, D. R.; Using chemical probes to investigate the sub-inhibitory effects of azithromycin; Org. Biomol. Chem.; 2008; 6; 4120-4124

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Ion Exchange Resins: Catalyst Recovery and Recycle

Barbaro, P.; Liguori, F.; Ion Exchange Resins: Catalyst Recovery and Recycle; Chem. Rev.; 2009; 109(2); 515-529

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Continuous-flow organic synthesis: a tool for the modern medicinal chemist

Wiles, C.; Watts, P.; Continuous-flow organic synthesis: a tool for the modern medicinal chemist; Future Med Chem.; 2009; 1(9); 1593-1612

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Total syntheses of the dipyrrolobenzoquinone (+)-terreusinone enabled by an evaluation of 4-methylpent-1-yn-3-ols

Wang, C.; Sperry, J.; Total syntheses of the dipyrrolobenzoquinone (+)-terreusinone enabled by an evaluation of 4-methylpent-1-yn-3-ols in the Larock indole synthesis; Tetrahedron; 2013; 69(23); 4563-4577

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Flow chemistry as a versatile tool for the synthesis of triazoles

Ötvös, S. B.; Fülöp, F.; Flow chemistry as a versatile tool for the synthesis of triazoles; Catal. Sci. Technol.; 2015; 5(11); 4926-4941

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An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition

Colley, H. E.; Muthana, M.; Danson, J. S.; Jackson, L. V.; Brett, M. L.; Harrison, J.; Coole, S. F.; Mason, D. P.; Jennings, L. R.; Wong, M.; Tulasi, V.; Noraman, D.; Lockey, P. M.; Williams, L.; Dossetter, A. G.; Griffen, E. J.; Thompson, M. J.; An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer; J. Med. Chem.; 2015; 58(23); 9309-9333

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Recent advances for serial processes of hazardous chemicals in fully integrated microfluidic systems

Singh, R.; Lee, H. J.; Singh, A. S.; Kim, D. P.; Recent advances for serial processes of hazardous chemicals in fully integrated microfluidic systems; Korean Journal of Chemical Engineering; 2016; 33(8); 2253-2267

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Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars

Bergeron-Brlek, M.; Meanwell, M.; Britton, R.; Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars; Nature Communications; 2015; 6; 1-11

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Merging Single-Atom-Dispersed Silver and Carbon Nitride to a Joint Electronic System via Copolymerization

Chen, Z.; Pronkin, S.; Fellinger, T. P.; Kailasam, K.; Vilé, G.; Albani, D.; Krumeich, F.; Leary, R.; Barnard, J.; Thomas, J. M.; Pérez-Ramírez, J.; Antonietti, M.; Dontsova, D.; Merging Single-Atom-Dispersed Silver and Carbon Nitride to a Joint Electronic System via Copolymerization with Silver Tricyanomethanide; ACS Nano; 2016; 10(3); 3166−3175

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Nitro Lignin-Derived Nitrogen-Doped Carbon as an Efficient and Sustainable Electrocatalyst for Oxygen Reduction

Graglia, M.; Pampel, J.; Hantke, T.; Fellinger, T. P.; Esposito D.; Nitro Lignin-Derived Nitrogen-Doped Carbon as an Efficient and Sustainable Electrocatalyst for Oxygen Reduction; ACS Nano; 2016; 10(4); 4364-4371

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Toward the Synthesis of Noroxymorphone via Aerobic Palladium-Catalyzed Continuous Flow N‑Demethylation Strategies

Gutmann, B.; Elsner, P.; Cox, D. P.; Weigl, U.; Roberge, D. M.; Kappe, C. O.; Toward the Synthesis of Noroxymorphone via Aerobic Palladium-Catalyzed Continuous Flow N‑Demethylation Strategies; ACS Sustainable Chem. Eng.; 2016; Article ASAP

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Origin of problems related to Staudinger reduction in carbopeptoid syntheses

Csordás, B.; Nagy, A.; Harmat, V.; Zsoldosné-Mády, V.; Leveles, I.; Pintér, I.; Farkas, V.; Perczel, A.; Origin of problems related to Staudinger reduction in carbopeptoid syntheses; Amino Acids; 2016; ?; 1-15

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Chemistry of 3-carbonyl-2-methyl-4-oxo-4H-1-benzopyrans

Ghosh, C. K.; Chakraborty, A.; Chemistry of 3-carbonyl-2-methyl-4-oxo-4H-1-benzopyrans; ARKIVOC; 2016; 2016(1); 111-149

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Synthetic multivalent ligands for cholera & cholera-like toxins: Protected cyclic neoglycopeptides

Kumar, V.; Yadav, N.; Kartha, K. P. R.; Synthetic multivalent ligands for cholera & cholera-like toxins: Protected cyclic neoglycopeptides; Carbohydrate Research; 2016; 431; 47-55

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Ligand ordering determines the catalytic response of hybrid palladium nanoparticles in hydrogenation

Albani, D.; Vilé, G.; Mitchell, S.; Witte, P. T.; Barrios, N. A.; Verel, R.; López, N.; Pérez-Ramírez, J.; Ligand ordering determines the catalytic response of hybrid palladium nanoparticles in hydrogenation; Catal. Sci. Technol.; 2016; 6(6); 1621-1631

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Fine chemical syntheses under flow using SiliaCat catalysts

Ciriminna, R.; Pandarus, V.; Béland, F.; Pagliaro, M.; Fine chemical syntheses under flow using SiliaCat catalysts; Catal. Sci. Technol.; 2016; 6(13); 4678-4685

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Insights into the activity, selectivity and stability of catalysts in the continuous flow hydroconversion of furfural

Garcia-Olmo, A. J.; Yepez, A.; Balu, A. M.; Romero, A. A.; Li, Y.; Lugue, R.; Insights into the activity, selectivity and stability of heterogeneous catalysts in the continuous flow hydroconversion of furfural; Catal. Sci. Technol.; 2016; 6(13); 4705-4711

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Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry

Lücke, D.; Dalton, T.; Ley, S. V.; Wilson Z. E.; Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry; Chem. Eur. J.; 2016; 22(12); 4206 - 4217

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Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Rossetti, I.; Comagnoni, M.; Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry; Chemical Engineering Journal; 2016; 296; 56-70

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Enzymatic Strategy for the Resolution of New 1-Hydroxymethyl Tetrahydro-b-carboline Derivatives in Batch

Megyesi, R.; Forró, E.; Fülöp, F.; Enzymatic Strategy for the Resolution of New 1-Hydroxymethyl Tetrahydro-b-carboline Derivatives in Batch and Continuous-Flow Systems; ChemistryOpen; 2016; 5(3); 254 - 260

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Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

Gallagher, C. M.; Garri, C.; Cain, E. L.; Ang, K. K. H.; Wilson, C. G.; Chen, S.; Hearn, B. R.; Jaishankar, P.; Aranda-Diaz, A.; Arkin, M. R.; Renslo, A. R.; Walter, P.; Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch; eLife; 2016; 5; e:11878

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Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies

Nuzzi, A.; Fiasella, A.; Ortega, J. A.; Pagliuca, C.; Ponzano, S.; Pizzirani, D.; Bertozzi, S. M.; Ottonello, G.; Tarozzo, G.; Reggiani, A.; Bandiera, T.; Bertozzi, F.; Piomelli, D.; Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies; Eur. J. Med. Chem.; 2016; 111; 138-159

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Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Z.; Pinson, J. A.; Mountford, S. J.; Orive, S.; Schoenwaelder, S. M.; Shackleford, D.; Powell, A.; Nelson, E. M.; Hamilton, J. R.; Jackson, S. P.; Jennings, I. G.; Thompson, P. E.; Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922); European Journal of Medicinal Chemistry; 2016; 122; 339-351

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Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis

Jarrad, A. M.; Debnath, A.; Miyamoto, Y.; Hansford, K. A.; Pelington, R.; Butler, M. S.; Bains, T.; Karoli, T.; Blaskovich, M. A. T.; Eckmann, L.; Cooper, M. A.; Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis; European Journal of Medicinal Chemistry; 2016; 120; 353-362

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Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow

Nagendiran, A.; Sörensen, H.; Johansson, M. J.; Tai, C. W.; Bäckvall, J. E.; Nanopalladium-catalyzed conjugate reduction of Michael acceptors - application in flow; Green Chem.; 2016; 18(9); 2632-2637

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Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent

Vianello, P.; Botrugno, O. A.; Cappa, A.; Zuffo, R. D.; Dessanti, P.; Mai, A.; Marrocco, B.; Mattevi, A.; Meroni, G.; Minucci, S.; Stazi, G.; Thaler, F.; Trifiró, P.; Valente, S.; Villa, M.; Mercurio, C.; Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent; J. Med. Chem.; 2016; 59(4); 1501-1517

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Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma

Onions, S. T.; Ito, K; Charron, C. E.; Brown, R. J.; Colucci, M.; Frickel, G. H.; Joly, K.; King-Underwood, J.; Kizawa, Y.; Knowles, I.; Murray, P. J.; Novak, A.; Rani, A.; Rapeport, G.; Smith, A.; Strong, P.; Taddei, D. M.; Williams, J. G.; Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma; Journal of Medicinal Chemistry; 2016; 59(5); 1727-1746

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SAR Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1,2 and BCR-ABL1 Inhibitors Targeting Leukemic Cells

Cherian, J.; Nacro, K.; Poh, Z. Y.; Guo, S.; Jeyaray, D. A.; Wong, Y. X.; Ho, M.; Yang, H. Y.; Joy, J. K.; Kwek, Z. P.; Liu, B.; Wee, J. L. K.; Ong, E. H.; Choong, M. L.; Poulsen, A.; Lee, M. A.; Pendharkar, V.; Ding, L. J.; Manoharan, V.; Chew, Y. S.; Sangthongpitag, K.; Lim, S.; Ong, S. T.; Hill, J.; Keller, T. H.; Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells; J. Med. Chem.; 2016; 59(7); 3063-3078

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Optically Pure, Structural, and Fluorescent Analogues of a Dimeric Y4 Receptor Agonist Derived by an Olefin Metathesis Approach

Liu, M.; Mountford, S. J.; Richardson, R. R.; Groenen, M.; Holliday, N. D.; Thompson, P. E.; Optically Pure, Structural, and Fluorescent Analogues of a Dimeric Y4 Receptor Agonist Derived by an Olefin Metathesis Approach; J. Med. Chem.; 2016; 59; 6059−6069

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Total Synthesis and Biological Evaluation of Tubulysin Analogues

Colombo, R.; Wang, Z.; Han, J.; Balachandran, R.; Daghestani, H. N.; Camarco, D. P.; Vogt, A.; Day, B. W.; Mendel, D.; Wipf, P.; Total Synthesis and Biological Evaluation of Tubulysin Analogues; J. Org. Chem.; 2016; Article ASAP

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Insights into the selective hydrogenation of levulinic acid to -valerolactone using supported mono- and bimetallic catalysts

Al-Naji, M.; Yepez, A.; Balu, A. M.; Romero, A. A.; Chen, Z.; Wilde, N.; Li, H.; Shih, K.; Gläser, R.; Luqueb, R.; Insights into the selective hydrogenation of levulinic acid to -valerolactone using supported mono- and bimetallic catalysts; Journal of Molecular Catalysis A: Chemical; 2016; 417; 145-152

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Development of biolubricants from vegetable oils via chemical modification

McNutt, J.; He, Q. S.; Development of biolubricants from vegetable oils via chemical modification; Journal of Industrial and Engineering Chemistry; 2016; 36; 1-12

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Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups

Workman, D. G.; Hunter, M.; Dover, L. G.; Tétard, D.; Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups and their evaluation as antimicrobial agents; Journal of Inorganic Biochemistry; 2016; 160; 49-58

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Synthesis of Deuterium-Labeled Antidiabetic Chalcones: Studies towards the Selective Deuteration of the Alkynone Core

Ötvös, S. B.; Hsieh, C. T.; Wu, Y. C.; Li, J. H.; Chang, F. R.; Fülöp, F.; Continuous-Flow Synthesis of Deuterium-Labeled Antidiabetic Chalcones: Studies towards the Selective Deuteration of the Alkynone Core; Molecules; 2016; 21(3); 318-329

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Library synthesis of cardiomyogenesis inducing compounds using an efficient two-step-one-flow process

Schön, M.; Dreier, D.; Schnürch, M.; Mihovilovic, M. D.; Library synthesis of cardiomyogenesis inducing compounds using an efficient two-step-one-flow process; Monatsh Chem; 2016; 147(3); 523-532

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New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics

Pilkington-Miksa, M.; Araldi, E. M.; Arosio, D.; Belvisi, L.; Civera, M.; Manzoni, L.; New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics; Org Biomol Chem.; 2016; 14(12); 3221-3233

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Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor

Salamoun, J. M.; McQueeney, K. E.; Patil, K.; Geib, S. J.; Sharlow, E. R.; Lazo, J. S.; Wipf, P.; Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor; Org. Biomol. Chem.; 2016; 14(27); 6398-6402

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Enabling the Scale-Up of a Key Asymmetric Hydrogenation Step in the Synthesis of an API

Amara, Z.; Poliakoff, M.; Duque, R.; Geier, D.; Francio, G.; Gordon, C. M.; Meadows, R. E.; Woodward, R.; Leitner, W.; Enabling the Scale-Up of a Key Asymmetric Hydrogenation Step in the Synthesis of an API Using Continuous Flow Solid-Supported Catalysis; Org. Process Res. Dev.; 2016; 20; 1321−1327

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Online monitoring and analysis for autonomous continuous flow self-optimizing reactor systems

Fabry, D. C.; Sugiono, E.; Rueping M.; Online monitoring and analysis for autonomous continuous flow self-optimizing reactor systems; React. Chem. Eng.; 2016; 1; 129-133

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Structuring hybrid palladium nanoparticles in metallic monolithic reactors for continuous-flow three-phase alkyne hydrogenation

Albani, D.; Vilé, G.; Toro, M. A. B.; Kaufmann, R.; Mitchell, S.; Ramírez-Pérez, J.; Structuring hybrid palladium nanoparticles in metallic monolithic reactors for continuous-flow three-phase alkyne hydrogenation; React. Chem. Eng.; 2016; 1; 454-462

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Reaction screening in continuous flow reactors

Mohamed, D. K. B.; Yu, X.; Li, J.; Wu, J.; Reaction screening in continuous flow reactors; Tetrahedron Lett.; 2016; Article ASAP

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HKUST-1 silica aerogel composites: novel materials for the separation of saturated and unsaturated hydrocarbons

Nuzhdin, A. L.; Shalygin, A. S.; Artiukha, E. A.; Chibiryaev, A. M.; Bukhtiyarova, G. A.; Martyanov, O. N.; HKUST-1 silica aerogel composites: novel materials for the separation of saturated and unsaturated hydrocarbons by conventional liquid chromatography; RSC Adv.; 2016; 6; 62501-62507

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In vitro reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors

Tan, G. Y.; Zhu, F.; Deng, Z.; Liu, T.; In vitro reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors; Synthetic and Systems Biotechnology; 2016; 1; 25-33

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Preparation of vinyl ethers using a Wittig approach, and their subsequent hydrogenation employing continuous-flow processing

Balti, M.; Efrit, M. L.; Leadbeater, N. E.; Preparation of vinyl ethers using a Wittig approach, and their subsequent hydrogenation employing continuous-flow processing; Tetrahedron Lett.; 2016; 57; 1804-1806

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Metathesis Reactions on Solid-Phase: Towards New Synthesis Challenges

Franzen, R. G.; Metathesis Reactions on Solid-Phase: Towards New Synthesis Challenges; Top Catal; 2016; 59; 1143-1150

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Regioselective catalytic alkylation of N-heterocycles in continuous flow

Sipocz, T.; Lengyel., L.; Sipos, G.; Kocsis, L.; Dorman, Gy.; Jones, R. V.; Darvas, F.; Regioselective catalytic alkylation of N-heterocycles in continuous flow; J. Flow Chem.; 2016; 6(2); 117-122

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Expedient Diels-Alder cycloadditions with ortho-quinodimethanes in a high temperature/pressure flow reactor

Tsoung, J.; Ying Wang, J.; Djuric, S. W.; Expedient Diels-Alder cycloadditions with ortho-quinodimethanes in a high temperature/pressure flow reactor; Reaction Chemistry and Engineering; 2017; available online

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