H-CUBE® MINI PLUS – APPLICATION OVERVIEW

H-Cube® Mini Plus Application Note

Technical parameters
Temperature range RT to 100°C
Pressure range ATM to 100 bar
Modes No gas or Full Hydrogen
Hydrogen generation 20-25 mL/min
Catalyst amount 0.1-0.3 g
Reaction type Starting material Product Conditions* Catalyst type
Triple bond full reduction Triple bond full reduction starting material Triple bond full reduction product 30 bar, RT Raney Nickel, 10% Pd/C
O-debenzylation O-debenzylation starting material O-debenzylation product 10 bar, 60 °C 10% Pd/C, 20% Pd(OH)2
Nitrile reduction Nitrile reduction starting material Nitrile reduction product 50 bar, 60 °C Raney Nickel, 10% Pd/C
Selective nitro reduction Selective nitro reduction starting material Selective nitro reduction product 70 bar, 25 °C 5% Ru/C, RuO2
Selective triple to double bond reduction Selective triple to double bond reduction starting material Selective triple to double bond reduction product 10 bar, RT Lindar catalyst (Pd catalyst on CaCO3, poisoned with Pb)
Selective double bond reduction Selective double bond reduction starting material Selective double bond reduction product 1 bar, RT 1% Ir/C, 5% Pt/CaCO3
Aldose reduction Aldose reduction starting material Aldose reduction product 90 bar, 100 °C Raney Nickel
Aromatic heterocycle reduction Aromatic heterocycle reduction starting material Aromatic heterocycle reduction product 70 bar, 70 °C 10% Pd/C, Raney Nickel
Aromatic ring reduction Aromatic heterocycle reduction starting material Aromatic heterocycle reduction product 25 bar, 50 °C 5% Rh/C, Ru black
Other heterogeneous catalytic reactions:
Deuteration (fill the tank with D2O instead of H2O) Deuteration starting material Deuteration product 1 bar, RT Pd/C catalyst (Use non-H2-saturated catalyst!)
Sonogashira coupling Sonogashira coupling starting material Sonogashira coupling product 100 bar, 100 °C FibreCat 1000-series
Suzuki coupling Suzuki coupling starting material Suzuki coupling product 20 bar, 100 °C FibreCat 1000-series
Kinetic resolution Kinetic resolution starting material Kinetic resolutiong product 1 bar, 40 °C Immobilized lipase enzyme