H-CUBE® MINI PLUS – APPLICATION OVERVIEW

H-Cube® Mini Plus Application Note

Technical parameters
Temperature rangeRT to 100°C
Pressure rangeATM to 100 bar
ModesNo gas or Full Hydrogen
Hydrogen generation20-25 mL/min
Catalyst amount0.1-0.3 g
Reaction typeStarting materialProductConditions*Catalyst type
Triple bond full reductionTriple bond full reduction starting materialTriple bond full reduction product30 bar, RTRaney Nickel, 10% Pd/C
O-debenzylationO-debenzylation starting materialO-debenzylation product10 bar, 60 °C10% Pd/C, 20% Pd(OH)2
Nitrile reductionNitrile reduction starting materialNitrile reduction product50 bar, 60 °CRaney Nickel, 10% Pd/C
Selective nitro reductionSelective nitro reduction starting materialSelective nitro reduction product70 bar, 25 °C5% Ru/C, RuO2
Selective triple to double bond reductionSelective triple to double bond reduction starting materialSelective triple to double bond reduction product10 bar, RTLindar catalyst (Pd catalyst on CaCO3, poisoned with Pb)
Selective double bond reductionSelective double bond reduction starting materialSelective double bond reduction product1 bar, RT1% Ir/C, 5% Pt/CaCO3
Aldose reductionAldose reduction starting materialAldose reduction product90 bar, 100 °CRaney Nickel
Aromatic heterocycle reductionAromatic heterocycle reduction starting materialAromatic heterocycle reduction product70 bar, 70 °C10% Pd/C, Raney Nickel
Aromatic ring reductionAromatic heterocycle reduction starting materialAromatic heterocycle reduction product25 bar, 50 °C5% Rh/C, Ru black
Other heterogeneous catalytic reactions:
Deuteration (fill the tank with D2O instead of H2O)Deuteration starting materialDeuteration product1 bar, RTPd/C catalyst (Use non-H2-saturated catalyst!)
Sonogashira couplingSonogashira coupling starting materialSonogashira coupling product100 bar, 100 °CFibreCat 1000-series
Suzuki couplingSuzuki coupling starting materialSuzuki coupling product20 bar, 100 °CFibreCat 1000-series
Kinetic resolutionKinetic resolution starting materialKinetic resolutiong product1 bar, 40 °CImmobilized lipase enzyme