H-Cube® Pro Application Notes

The following application notes show the wide range of chemical reactions and synthetic methods which can be implemented in our H-Cube® continuous flow reactor systems.


Guideline towards the synthesis of 3D shaped N-heterocycles

This guide provides information on the optimized, general conditions for the hydrogenation of different N-heterocycles in order to easily generate novel compounds with a higher sp3/sp2 ratio.


Hydrogenation of D-glucose to D-sorbitol using continuous flow hydrogenation apparatus

This application note demonstrates the H-Cube Pro’s increased productivity in the hydrogenation of D-glucose to D-sorbitol, which is believed to be a key intermediate in biofuel production. Both the use of elevated temperatures and increased concentration were proven to be advantageous for the outcome of the reaction, resulting in higher selectivity of the desired compound and higher throughput over the H-Cube Pro continuous flow system.


Increased throughput delivered by the new H-Cube® Pro

The H-Cube® Pro improves upon the original H-Cube® by offering greater hydrogen production (up to 60 mL/min) for higher throughput, wider temperature range (from 10 – 150 °C) including – for the first time – active cooling for more selective reactions. In this application note, we compare the H-Cube® with the new H-Cube® Pro in terms of throughput. The aim is to see how much more concentrated we can run a reaction on the H-Cube® Pro by taking advantage of the greater hydrogen production capability.


Medicinal chemistry application of chemoselective hydrogenation of multiple functional groups

Flow hydrogenation can be applied in many different reaction pathways complementing traditional batch chemistry efforts, however, articles describing chemoselective hydrogenations in a single flow process are scarce.


Reaction optimization and real-time analysis using ThalesNano’s platform and Mettler Toledo’s FlowIR™ spectrometer

In this application note we report on the optimization of hydrogenation, oxidation and ring-closing reactions and their real time analysis. Homogeneous and heterogeneous reactions were performed in ThalesNano’s H-Cube® Pro™, Gas Module and Phoenix Flow Reactor™ systems, while these reactions were monitored by Mettler Toledo’s FlowIR™ device.


Simple flow deuterodehalogenation using polymer-based activated carbon (PBSAC) supported palladium catalysts in CatCart®

Deuterium-labelling is a widely used method in the fields of biomedical, chemical and pharmaceutical industry.

The FDA recently approved the first deuterated API, and nowadays several molecules with deuterated moieties are under clinical testing in order to treat Alzheimer’s, cystic fibrosis, Freidreich’s ataxia, and psoriasis. The kinetic isotope effect enhances pharmacokinetic properties of deuterium-labelled molecules, which might lead to high therapeutic values.

Continuous-flow deuteration has been demonstrated in the H-Cube® before, however the possibility to use it in a green chemical solvent is practically unexplored.


Synthesis of nanoparticles and their efficient use in the H-Cube® and H-Cube® Pro flow reactors for reductions and H-D exchange reactions

In this application note we demonstrate the results of newly developed Pd, Ni nanocomposites and immobilized Ir complex catalysts for a wide range of chemical applications.