Other Application Notes

Fast optimization of continuous flow hydrogenation reactions using CatCart® Changer

The optimization of reactions is a time-consuming process. Particularly when there are many different parameters to optimize. When hydrogenation is performed in batch reactors, if different temperatures, catalysts or pressures need to be validated, a separate reaction must be performed for each set of conditions. With the H-Cube® and the CatCart® Changer system, injections can be made at different temperatures and pressures on different catalysts, without having to perform separate reactions.

Flash vacuum pyrolysis, the key step in the synthesis of a novel oxadiazolo-pyrimidinone library

While a number of avenues are available to organic chemists for the synthesis of novel structures, it has also been shown that chemists employ a relatively small chemical technology toolbox that is limiting the potentially attainable chemical space, in conventional laboratories all around the world. It is especially true once extreme process conditions are applied in order to attain the desired, (in most cases novel) compounds. In response to these limitations and needs, we have developed and launched the Flash Pyrolysis Platform onto the market that reaches beyond the already known capabilities of the usual vacuum flash pyrolysis instruments by enabling one to apply non-volatile starting materials as well, via our own interchangeable vaporizer system.

Guideline towards the synthesis of 3D shaped N-heterocycles

This guide provides information on the optimized, general conditions for the hydrogenation of different N-heterocycles in order to easily generate novel compounds with a higher sp3/sp2 ratio.

Reaction optimization and real-time analysis using ThalesNano’s platform and Mettler Toledo’s FlowIR™ spectrometer

In this application note we report on the optimization of hydrogenation, oxidation and ring-closing reactions and their real-time analysis. Homogeneous and heterogeneous reactions were performed in ThalesNano’s H-Cube® Pro, Gas Module™ and Phoenix Flow Reactor™ systems, while these reactions were monitored by Mettler Toledo’s FlowIR™ device.

Optimization of N-alkylation in the Phoenix Flow Reactor using 45 MHz picoSpin bench-top NMR for monitoring

Flow chemistry is a widely accepted technique in the synthesis field and makes optimization fast and convenient. Benchtop NMR instruments allow chemists to measure 1H NMR spectra directly in the fume hood and monitor pseudo-real-time behavior of reaction chemistries.