X-Cube Application Notes

Please note that the X-Cube system is no longer manufactured and supported. For a newer instrument designed for similar application, please check out the H-Cube systems.


Carbon-carbon coupling reactions using the X-Cube™ continuous flow reactor

The X-Cube™ is a continuous flow reactor, capable of performing chemical reaction under inert conditions, temperatures up to 200°C and pressures up to 150 bar. This paper shows that carbon-carbon bond forming reactions are far more efficient on the X-Cube™ in comparison to batch mode.


Lipase-catalyzed kinetic resolution using X-Cube™ continuous flow reactor

Enzyme catalyzed biotransformation reactions are now widely used in the chemical industry, most commonly in the synthesis of fine chemicals, but also in the production of drugs, agrochemicals and plastics. One of these enzymes is the lipase which can catalyze hydrolysis and also the esterification of ester chemical bonds in lipid substrates. The main reason for using these enzymes is that they provide enantiomerically pure products during a reaction, often with higher purity than what can be achieved by non-enzyme enantiomer catalysts. Enzymes can be utilized in kinetic resolution, based on the different activity of enantiomers in certain reactions.


Reductive amination of ketones: novel one-step transfer hydrogenations

Amines are indispensable building blocks in numerous drugs, pesticides and colour pigments. Development of general and efficient methods to prepare amino-compounds is still of high interest to the chemical industry. One of the most convenient methods to synthesize amines is the reductive amination of carbonyl compounds.


Ruthenium-catalyzed metathesis reaction using fixed-bed continuous flow reactor

Olefin metathesis is an excellent method for the preparation of new rings and valuable intermediates in organic synthesis and polymer chemistry. The development of metathesis catalysts that combine high activity with a tolerance towards different functional groups has been important for the widespread utilization of this application. Out of all the various catalysts that have been reported, the ruthenium type catalysts have the widest application due to their easy handling and substrate variability.