Aromatic nucleophilic substitutions using X-Cube Flash™ continuous flow reactor
ThalesNano has developed a high pressure/high temperature continuous flow reactor, called X-Cube Flash™, as a viable alternative to MW-chemistry. Several reactions previously reported under MW conditions were realized in the X-Cube Flash™ with improved yield and radically shortened reaction time under safe operation. Our objective was to study the nucleophilic aromatic substitution reaction (F-amine exchange) in metapositions, since the substituted mono- and diaminobenzonitriles are important biological active molecules.
Chemistry at high temperature and pressure – using the X-Cube Flash™ continuous flow reactor
The X-Cube Flash™ is a continuous-flow system that can heat and pressurize solutions up to 350°C and 200 bar respectively. The high temperature and pressure significantly decrease reaction times and allows solvents to be reacted under supercritical conditions. This application note demonstrates the results of important chemical reactions carried out in the X-Cube Flash™ reactor with comparison to literature results based on conventional batch or microwave-assisted reactions.
Efficient Curtius-rearrangement using X-Cube Flash™ continuous flow reactor
ThalesNano has developed a high pressure/high temperature continuous flow reactor, called X-Cube Flash™, to allow chemists to reach chemistry reaction extremities easier and safer compared to batch. In this application note we will focus on the study of the Curtius-reaction from an acyl azide as well ans from acids through in situ formation of the acyl azide using the X-Cube Flash™ reactor.
Thermal cyclisation leading to important heterocyclic carbonyl intermediates using X-Cube Flash™ reactor
Heterocyclic carbonyl compounds e.g. quinolones, pyridopyrimidinones, naphthyridinones are important structural motifs in various biological active compounds (e.g. norfloxacin, nalidixic acid). One of the most practical approaches for their synthesis is the thermal cyclisation of the appropriate open chain intermediates containing a suitably substituted 3 carbon extension on the nitrogen.