Safe and fast ozonolysis using the IceCube Flow Reactor

Ozonolysis is a fundamentally important oxidation reaction, which has never been fully adopted due to the safety concerns with performing the process. Its main importance stems from the fact that you can selectively oxidize double or triple bonds to form hydroxyl groups, aldehydes or carboxylic acids in the presence of other oxidizable groups. Other conventional oxidative methods are not so selective, are slower to react, require addition of water or need purification to eliminate side products leading to lower yields or need the use of metal catalysts. Compared to other methodologies, ozonolysis is considered as a greener way of oxidation. Ozonolysis has been used frequently in major drug syntheses such as (+)-Artemisinin, Indolizidine 251F, and D,L-Camptothecin and with finechemical syntheses such as L-Isoxazolylalanine and Prostaglandin endoperoxides.

Download