Scale-up of a reductive amination reaction using H-Cube Midi reactor

Reductive amination is widely used as a form of amination between an aldehyde or ketone and a primary amine or ammonia. The reaction can be done either in two steps, via indirect reductive amination and performing the reduction after isolation of the imine compound, or simultaneously by choosing a way of reduction which prefers the reduction of the protonated imine over the reduction of starting material. Catalytic hydrogenation matches these criteria, e.g. Raney Nickel and can be used at low pressure and avoids the difficult purification processes when utilizing borohydrides.

Download