Simple, fast and safe continuous flow nitrations with the IceCube Flow Reactor

Nitration of aromatics is one of the oldest and industrially most important reactions. A reaction between an organic compound and a nitrating agent leads to the introduction of a nitro group onto a carbon, nitrogen or oxygen atom of that organic compound. Nitro derivatives of aromatic compounds are used in a variety of basic and specialty chemicals that are employed in dyes, perfumes, pharmaceuticals, explosives, intermediates, colorants, and pesticides. Almost 65% of APIs require at least one nitration step in the whole process.