Thermal cyclisation leading to important heterocyclic carbonyl intermediates using X-Cube Flash™ reactor

Heterocyclic carbonyl compounds e.g. quinolones, pyridopyrimidinones, naphthyridinones are important structural motifs in various biological active compounds (e.g. norfloxacin, nalidixic acid). One of the most practical approaches for their synthesis is the thermal cyclisation of the appropriate open chain intermediates containing a suitably substituted 3 carbon extension on the nitrogen.