Green chemistry

Did you know that ThalesNano’s products can also improve chemistry by complying with many of the principles of green chemistry? Below are a few examples of how we achieve that.

Waste prevention

The H-Cube series’ Catcarts® allow catalysts to be recycled and used with different substrates making the most out the Earth’s limited natural resources. When using catalysts in batch systems, the catalysts are filtered using Ceelite and then disposed of.

Less hazardous chemical syntheses

ThalesNano Cube reactors reduce the risks associated with hazardous chemical syntheses. Specifically, the H-Cube® makes hydrogenation safer by removing the need for hydrogen cylinders and catalyst filtration. ThalesNano’s new Ice Cube system makes high energy processes such as ozonolysis safer to perform.

Designing safer chemicals, solvents and auxiliaries

The H-Cube series all use catalyst cartridges, CatCarts® which allow the user to handle pyrophoric catalysts safely, even Raney® catalysts. When using batch reactors, catalyst filtration is required and is a hazardous step. With the CatCarts® this step is not necessary.

Energy efficiency

Utilizing flow methodology means that heating a reaction mixture to temperature uses less energy because only a small amount of the reaction material is present at one time. When moving to larger scales this efficiency improves drastically.

Use of renewable materials

See Waste prevention answer.

Real time analysis

Our systems are compatible with Mettler Toledo’s FlowIR™ system for real time analysis of your reaction mixture.

Safer chemistry and accident prevention

With the removal of hydrogen cylinders and the catalyst filtering process coupled with closer temperature control of high energy reactions, our product line makes hazardous chemistry safer to perform and prevents accidents.

Reduce derivatives and synthesis steps

The ability to use previously inaccessible chemistries with our flow instruments means that routes can now be re-examined in order to reduce steps and save costs. High temperature syntheses means that chemists can now look to reducing catalyst or reagent stoichiometries.

The H-Cube Autosampler™ system can reduce the number of synthetic steps in a library. e.g. A nitro compound must be reduced to form an amine, which will act as a proton donator in the final compound. In batch synthesis, the hydrogenation would be performed on a large scale at the beginning of the synthesis and the resulting amine protected and deprotected as a last step. The reduction of the nitro group as a last step in a library synthesis, negating the need for protection and deprotection steps, cannot be performed in a batch mode due to the large number of compounds involved. It would take too long a time. With the H-Cube Autosampler™, 50 compounds may be reduced overnight allowing this process to be performed in an automated fashion for the first time.