Hydrogenation

On-demand hydrogen generation to eliminate hydrogen cylinders

Catalytic hydrogenation stands as a cornerstone in the realm of modern chemical industry, offering significant transformations with diverse applications. Heterogeneously catalyzed hydrogenations are widely employed for a range of crucial conversions, including:

• Reduction of double or triple bonds
• Nitro-group reduction
• Debenzylation reactions
• Heterocycle saturations
• Dehalogenation reactions
• Desulphurization reactions
• Asymmetric hydrogenations

Traditionally, hydrogenations have been performed using batch technology, yet this approach presents several disadvantages:

• The use of hydrogen cylinders poses a safety hazard.
• The catalysts themselves can be pyrophoric, making their addition or filtration a hazardous process.
• The degassing of solvents and purging of reactors with inert gases add unnecessary complexity to the reactions.
• Poor mixing of hydrogen with solvents and catalysts results in lengthy reaction times.

These combined drawbacks have prompted chemists to seek alternatives, avoiding the otherwise valuable transformation. At ThalesNano, we have developed the H-Cube reactors and the H-Genie hydrogen generators to introduce safe and convenient hydrogenation practices in the laboratory.

The first H-Cube system was a revolutionary concept in the early 2000s, allowing the generation and use of high-pressure hydrogen gas in continuous flow (up 100 bar pressure ad 100 °C temperature). Since then, it has been instrumental in transforming hydrogenation laboratory practices and scientific research. With over 700 publications showcasing the impact of the H-Cube series reactors, they have proven to be essential in advancing the field of chemistry.

Explore our extensive collection of articles and application notes to witness the diverse range of applications where H-Cube systems have excelled over the past two decades. From state-of-the-art research to practical laboratory workflows, discover how the H-Cube reactors have revolutionized hydrogenation reactions and empowered scientists worldwide.

Introducing on-demand hydrogen generation—an innovative solution that addresses the limitations of traditional methods and eliminates the need for hydrogen cylinders entirely. Our H-Cube and H-Genie systems employ patented technologies that enable the generation of high-pressure hydrogen via water electrolysis. This groundbreaking approach not only simplifies laboratory processes but also enhances safety, meeting stringent laboratory regulations as there is no longer a requirement to store hydrogen gas.

The generated hydrogen gas can be readily utilized for a wide range of chemical transformations, catering to both traditional batch reactors and flow chemistry equipment. This revolutionary capability equips synthetic chemists with an invaluable tool, setting a new standard for hydrogenations on a laboratory scale.

Learn more about the convenience, safety, and flexibility of on-demand hydrogen generation with our H-Cube and H-Genie systems through our application notes and scientific publication collection.

The H-Genie hydrogen generators offer a versatile solution to perform safe and convenient hydrogenation in both batch and flow reactors (up to 100 bar pressure). These instruments serve as an efficient alternative to traditional hydrogen cylinders, offering enhanced flexibility for various applications.