H-Cube® Mini Plus

Safe and easy hydrogenation with on-demand hydrogen generation

Hydrogenation in continuous flow

The H-Cube® Mini Plus is a safe, powerful and affordable flow reactor which generates high-pressure hydrogen gas on-demand with the electrolysis of water, allowing chemists to perform catalytic hydrogenation reactions from atmospheric pressure and room temperature to 100 bar and 100 °C in minutes.

Safety and convenience for hydrogenation

Hydrogenation is one of the most important reactions in chemical synthesis, but the hazardous nature of hydrogen limits its use. The H-Cube® series have already eliminated the dangers associated with hydrogenation through the use of in situ hydrogen generation and the handling of pyrophoric catalysts by filling them in sealed catalyst cartridges (CatCarts®). This technology has been adopted by the leaders in the pharmaceutical, flavor and fragrance, fine chemical, agrochemical industries and in academia.

Features of the H-Cube® Mini Plus

  • Hydrogenation without cylinders
  • No catalyst filtration
  • Fast reactions
  • Easy-to-use
  • Affordable
  • Built-in video tutorial
  • Automated hydrogen drying system

How does the H-Cube® Mini Plus work?

  • The hydrogen is generated by the electrolysis of water inside the system.
  • The HPLC pump introduces the pure solvent into the system, where it is mixed using a mixing valve with the hydrogen.
  • The gas-liquid mixture passes through the reaction zone while the system prepares to work at the selected parameters (pressure, temperature and flow rate).
  • When the desired parameters are achieved, the user can change the input from the solvent to the solution of the reactants.
  • The reaction mixture passes through a packed column containing the solid catalyst (CatCart®), where the reaction takes place. The product leaves the column, but the catalyst stays behind.
  • The product is collected in the collection vial.
  • The reaction scale can be varied from milligrams to grams.


Reactions with hydrogen gas:

Triple bond full reduction, debenzylation, nitrile reduction, selective nitro reduction, selective triple to double bond reduction, selective double bond reduction, aldose reduction, aromatic heterocycle reduction, aromatic ring reduction, etc.

Other reactions:

Deuteration, Sonogashira coupling, Suzuki coupling, etc.

Technical data

System specifications of the H-Cube® Mini Plus
Temperature rangeFrom room temperature to 100°C
Pressure rangeFrom atmospheric pressure to 100 bar
Flow rate0.3 – 3 mL/min
Maximum hydrogen production rate25-30 NmL/min
Water reservoir capacity100 mL
Water specificationsDeionized water with maximum conductivity of 71 nS/cm (min. resistance 14 MΩcm)
Dimensions• Width: 217 mm (8.54″)
• Height: 200 mm (7.87″) with closed display, 315 mm (12.4″) with opened
• Depth: 290 mm (11.42″)
Weight7.3 kg (16.09 lb)
Voltage100 – 240 V AC
Typical catalyst amount0.1 – 0.3 g
Recommended concentration0.01 – 1 M


In short, the H-Cube Mini Plus is the simplified version of the more sophisticated H-Cube Pro, while the Phoenix scale-up platform is used for scale-up and high throughput processes.
Yes, chemists at any level can easily learn how to use the H-Cube Mini Plus within minutes. The H-Cube Mini Plus is the first instrument helping the users with embedded support videos about general use and troubleshooting.
Yes, please do not hesitate to contact our chemistry team for advice at askthechemist@thalesnano.com.
Yes, both the 30 mm and 70 mm sizes are compatible.
H-Cube Mini Plus can work in hydrogen mode ON for hydrogenations, or hydrogen mode OFF for catalytic reactions that do not require hydrogen, such as C-C coupling reactions.
Yes, just change deionized water to deuterium oxide. Please find more information here.
Coupling reactions, such as Suzuki and Heck reactions are generally performed in our H-Cube Series reactors. Also, reactions with enzymes can be performed with these systems. Please browse our publication collection for more information.

Do you have more questions?

Reach out to us at any time and experience fast and efficient support tailored to your specific needs.