High Temperature Reactions

In chemistry, temperature is the most important physical parameter to achieve the activation energy needed to perform a reaction. Flow chemistry methods enable precise control of this parameter, thus, the outcome of the reaction can be controlled as well. According to the Arrhenius equation, with a 10 °C rise in temperature the reaction rates double. Many reactions in chemistry need high temperature to reach the desired conversion or yield, but with traditional batch equipment, chemists can only reach 250-280°C in a safe environment and with this parameter barrier, numerous reactions are unavailable or take long time to fulfill.

High Temperature Instruments by ThalesNano

One of the most important properties of flow systems is that they handle only a small volume of reagents at a given time. In this environment, the temperature can be safely elevated higher than in batch flasks and by applying the right pressure, the solvent can be heated high above its boiling point, while it still stays in liquid phase. These circumstances enable reactions which are impossible to perform in batch.

High temperature reaction with the Phoenix™ Flow Reactor

ThalesNano’s Phoenix Flow Reactor can work up to 450°C using SS loops (4, 8 or 16 mL) or catalyst cartridge system (ThalesNano’s CatCarts, MidiCarts or 125 mm and 250 mm stainless steel metal-metal sealed cartridges). Whit this system, reactions, such as N-alkylation with alcohols on Raney Nickel catalyst, work over 250°C in minutes with good selectivity and yield.

ThalesNano’s Flash Pyrolysis Platform can reach even higher temperatures. With this instrument, the maximum temperature is 1000°C in vapor phase, using high vacuum at the collecting side. Preheating the staring material, it evaporates in the inner volume of the vessel, and in vacuum, the reaction occurs in milliseconds. The reactor can work in liquid phase as well, with a 400 mm stainless steel cartridge.

For more information, please contact us at askthechemist@thalesnano.com.