H-Cube Mini Plus™

Safe, simple and affordable hydrogenation

The H-Cube Mini Plus is a safe, powerful and affordable reactor that generates high-pressure hydrogen from water electrolysis, allowing chemists to perform catalytic hydrogenations from atmospheric pressure and room temperature to 100 °C and 100 bar in minutes.

Hydrogenation is one of the most important reactions in chemical synthesis, but the hazardous nature of hydrogen limits its use. The H-Cube Series have already eliminated the dangers associated with hydrogenation through the use of in situ hydrogen generation and the handling of pyrophoric catalysts by filling them in sealed catalyst cartridges (CatCarts). This technology has been adopted by the leaders in the pharmaceutical, flavor and fragrance, fine chemical, agrochemical industries and in academia.

The H-Cube Mini Plus’s hydrogen generation system can be easily turned off to allow heterogeneously catalyzed non-hydrogenation reactions to be performed as well, such as C-C coupling reactions.


  • Hydrogenation without cylinders
  • No catalyst filtration
  • Fast Reactions
  • Easy to use
  • Academia budget compatible
  • Built-in video tutorial
  • Automated hydrogen drying system

How does it work?

  • The hydrogen is generated by the electrolysis of water inside the system.
  • The HPLC pump introduces the reactant solution into the device, where it mixes with the hydrogen.
  • A continuous flow of hydrogen and solvent are passed through the reactor while the system prepares to work at the selected parameters (pressure, temperature and flow rate).
  •  When the desired parameters are achieved, the user can change the input from the solvent to the reactant solution.
  • The hydrogen/starting material solution mix is passed through a packed column containing solid catalyst (CatCart), where the reaction takes place. The product leaves the column, but the catalyst stays behind.
  • The product is collected in the collection vial.
  • Reductions vary in scale from 10 mg-10 g of product.
Technical Parameters of the H-Cube Mini Plus™
Temperature Range Ambient to 100°C
Pressure Range 1 bar to 100 bar
Flow Rate 0.1 – 3 mL/min
Hydrogen Generation 25-30 mL/min
Water Reservoir Capacity 100 mL
Dimensions •  Width: 217 mm (8.54″)
• Height: 200 mm (7.87′) with closed display, 315 mm (12.4″) with opened
• Depth: 290 mm (11.42″)
Weight 7.3 kg (16.09 lb)
Voltage 100 – 240 V AC
Catalyst Amount 0.1 – 0.3 g
Concentration 0.01 – 1M


In short, the H-Cube Mini Plus is a simpler version of the more sophisticated H-Cube Pro, and H-Cube Midi is used for scale-up and high throughput processes.

Yes, chemists at any level can easily learn how to use the H-Cube Mini Plus within minutes. The H-Cube Mini Plus is the first instrument helping the users with embedded support videos about general use and troubleshooting.
Yes, you can either contact our chemistry team for advice by e-mail at askthechemist@thalesnano.com, or we can provide you the Practical Lab Book for the H-Cube Mini Plus.
Yes, both the 30 mm and 70 mm sizes are compatible.
No, the system will not be compatible with ThalesNano AutoSampler system.
H-Cube Mini Plus can work in hydrogen mode ON for hydrogenations, or hydrogen mode OFF for catalytic reactions that do not require hydrogen, such as C-C coupling reactions.
Yes. Just change deionized water to deuterium oxide.
Coupling reactions, such as Suzuki and Heck reactions are generally performed in our H-Cube Series reactors. Also, reactions with enzymes can be performed with these systems.

Links for further information

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