Publications

ThalesNano has set a new standard for laboratory-scale continuous flow reactions, especially on the field of hydrogenation. Our instruments have been used all around the world for a wide range of applications and have been featured in numerous scientific publications.

Browse our poblications in alphabetical order below, filter by catalyst, device, industry or reaction type, or download the complete list.

1,3,5-Trisubstituted pyrazoles as potent negative allosteric modulators of the mGlu2/3 receptors

Van Gool, M.; Alonso De Diego, S. A.; Delgado, O.; Trabanco, A. A.; Jourdan, F.; Macdonald, G. J.; Somers, M.; Ver Donck, L.; ChemMedChem, 2017, 12(12), 905-912

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1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activity

Abdel-Hamid, M. K.; Macgregor, K. A.; Odell, L. R.; Chau, N.; Mariana, A.; Whiting, A.; Robinson, P. J.; McCluskey, A.; Org. Biomol. Chem., 2015, 13, 8016-8028

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2,7-Pyrrolo[2,1-f][1,2,4]triazines as JAK2 inhibitors: modification of target structure to minimize reactive metabolite formation

Weinberg, L. R.; Albom, M. S.; Angeles, T. S.; Breslin, H. J.; Gingrich, D. E.; Huang, Z.; Lisko, J. G.; Mason, J. L.; Milkiewicz, K. L.; Thieu, T. V.; Underiner, T.L .; Wells, G. J.; Wells-Knecht, K. J.; Dorsey, B. D.; Bioorg. Med. Chem. Lett., 2011, 21(4), 7325-7330Link to article

3‐Aminoazetidin‐2‐one derivatives as N‐acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration

Fiasella, A.; Nuzzi, A.; Summa, M.; Armirotti, A.; Tarozzo, G.; Tarzia, G.; Mor, M.; Bertozzi, F.; Bandiera, T.; Piomelli, D.; ChemMedChem, 2014, 9(7), 1602-1614

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3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Ferrins, L.; Rahmani, R.; Sykes, M. L.; Jones, A. J.; Avery, V. M.; Teston, E.; Almohaywi, B.; Yin, J.; Smith, J.; Hyland, C.; White, K. L.; Ryan, E.; Campbell, M.; Charman, S. A.; Kaiser, M.; Baell, J. B.; Eur. J. Med. Chem., 2013, 66, 450-465

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3-Substituted xanthines as promising candidates for quadruplex formation: computational, synthetic and analytical studies

Szolomajer, J.; Paragi, G.; Batta, Gy.; Guerra, F. C.; Bickelhaupt, F. M.; Kele, Z.; Padar, P.; Kupihar, Z.; Kovacs, L.; New Journal of Chemistry, 2011, 35, 476-482

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4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as high-affinity non-imidazole histamine H3 receptor agonists with in vivo central nervous system activity

Wagner, G.; Mocking, T.; Arimont, M.; Provensi, G.; Rani, B.; Silva-Marques, B.; Latacz, G.; Da Costa Pereira, D.; Karatzidou, K.; Vischer, H. F.; Wijtmans, M.; Kiec-Kononowicz, K.; De Esch, I. J. P.; Leurs, R.; J. Med. Chem., 2019, accepted manuscript

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4′-C-methyl-2-deoxyadenosine and 4-C-ethyl-2-deoxyadenosine inhibit HIV-1 replication

Vu, B. C.; Boyer, P. L.; Siddiqui, M. A.; Marquez, V. E.; Hughes, S. H.; Antimicrobial Agents and Chemotheraphy, 2011, 55(5), 2379-2389

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4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-based P2X7 receptor antagonists: optimization of pharmacokinetic properties leading to the identification of a clinical candidate

Letavic, M. A.; Savall, B. M.; Allison, B. D.; Aluisio, L.; Andres, J. I.; De Angelis, M.; Ao, H.; Beauchamp, D. A.; Bonaventure, P.; Bryant, S.; Carruthers, N. I.; Ceusters, M.; Coe, K. J.; Dvorak, C. A.; Fraser, I. C.; Gelin, C. F.; Koudriakova, T.; Liang, J.; Lord, B.; Lovenberg, T. W.; Otieno, M. A.; Schoetens, F.; Swanson, D. M.; Wang, Q.; Wickenden, A. D.; Bhattacharya, A.; J. Med. Chem., 2017, 60(11), 4559-4572

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Synthesis, antiplasmodial activity and in silico molecular docking study of pinocembrin and its analogs

Melaku, Y. et al.; BMC Chemistry, 2022, 16:36

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Synthesis of 12β-methyl-18-nor-avicholic acid analogues as potential TGR5 agonists

Ure, E. M. et al.; Org. Biomol. Chem., 2022, 20, 3511-3527

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α-1,4-Galactosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins

Simerska, P.; Christie, M. P.; Goodwin, D.; Jen, F. E-C.; Jennings, M. P.; Toth, I.; Journal of Molecular Catalysis B: Enzymatic, 2013, 97, 196-202

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A benchtop continuous flow reactor: a solution to the hazards posed by gas cylinder based hydrogenation

Dorman, G.; Kocsis, L.; Jones, R.; Darvas, F.; Journal of Chemical Health and Safety, 2013, 20(4), 3-8

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A comparative assessment study of known small-molecule Keap1−Nrf2 protein–protein interaction inhibitors: Chemical synthesis, binding properties, and cellular activity

Tran, K. T.; Pallesen, J. S.; Solbak, S. M. O.; Narayanan, D.; Baig, A.; Zang, J.; Aguayo-Orozco, A.; Carmona, R. M. C.; Garcia, A. D.; Bach, A.; J. Med. Chem., 2019, 62(17), 8028-8052

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A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Gambarcorta, G. et al.; Beilstein J. Org. Chem., 2021, 17, 1181-1312

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A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

Baumann, M.; Baxendale, I. R.; Deplante, F.; Beilstein J. Org. Chem., 2017, 13, 2549-2560

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A concise stereoselective synthesis of pterosin B

Dexter, H. R.; Allen, E.; Williams, D. M.; Tetrahedron Letters, 2018, 59(49), 4323-4325

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A continuous-flow approach to palladium-catalyzed alkoxycarbonylation reactions

Kelly, C. B.; Lee, C. (X.); Mercadante, M. A.; Leadbeater N. E.; Org. Process Res. Dev., 2011, 15(3), 717-720

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A continuous-flow microwave reactor for conducting high-temperature and high-pressure chemical reactions

Sauks, J. M.; Mallik, D.; Lawryshyn, Y.; Bender, T.; Organ, M.; Org. Process Res. Dev., 2014, 18(11), 1310-1314

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A continuous flow process for the green and sustainable production of N-alkyl imidazoles

Fekete, M.; Kocsis L.; Dorman, G.; Jones, R. V.; Darvas, F.; Green Processing and Synthesis, 2016, 5(3), 239-246

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A continuous flow process for the production of 2,5-dimethylfuran from fructose using (non-noble metal based) heterogeneous catalysis

Braun, M.; Antonietti, M.; Green Chemistry, 2017, 19, 3813-3819

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A continuous flow strategy for the facile synthesis and elaboration of semi-saturated heterobicyclic fragments

Luise, N.; Wyatt, E. W.; Tarver, G. J.; Wyatt, P. G.; Eur. J. Org. Chem., 2018, 2019(6), 1341-1349

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A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

Viviano, M.; Milite, C.; Rescigno, D.; Castellano, S.; Sbardella, G.; RSC Adv., 2015, 5, 1268-1273

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A continuous flow system for asymmetric hydrogenation using supported chiral catalysts

Madarasz, J.; Farkas, G.; Balogh, S.; Szollosy, A.; Kovacs, J.; Darvas, F.; Urge, L.; Bakos, J.; J. Flow Chem., 2011, 1(2), 62-67

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A continuous-flow, two-step, metal-free process for the synthesis of differently substituted chiral 1,2-diamino derivatives

Pirola, M.; Compostella, M. E.; Raimondi, L.; Puglisi, A.; Benaglia, M.; Synthesis, 2018, 50, 1430-1438

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A continuous process for glyoxal valorisation using tailored Lewis-acid zeolite catalysts

Dapsens, P. Y.; Mondelli, C.; Kusema, B. T.; Verel, R., Perez-Ramirez, J.; Green Chemistry, 2014, 16, 1176-1186

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A Continuous‐Flow Process for Palladium‐Catalyzed Olefin Cleavage by using Oxygen within the Explosive Regime

Hone, C. A. et al.; ChemCatChem, 2017, 9, 3298-3302

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A Facile hybrid ‘flow and batch’ access to substituted 3,4-dihydro-2H-benzo[b][1,4]oxazinones

Lin, A. J. S. et al.; Org. Biomol. Chem., 2016, 14, 8732-8742

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A facile, protic ionic liquid route to N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides and N-substituted 3-oxoisoindoline-4-carboxylic acids

Gordon, C. P.; Byrne, N.; McCluskey, A.; Green Chem., 2010, 12, 1000-1006

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A flexible approach to 6,5-benzannulated spiroketals

Wilson, Z. E.; Hubert, J. G.; Brimble, M. A.; Eur. J. Org. Chem., 2011, 2011(20-21), 3938-3945

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A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core

Hay, D. A.; Adam, F. M.; Bish, G.; Calo, F.; Dixon, R.; Fray, M. J.; Hitchin, J.; Jones, P.; Paradowski, M.; Parsons, G. C.; Proctor, K. J. W.; Pryde, D. C.; Smith, N. N.; Tran, T. D.; Tetrahedron Letters, 2011, 52(44), 5728-5732

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A flow-based synthesis of telmisartan

Martin, A. D.; Siamaki, A. R.; Belecki, K.; Gupton, B. F.; J. Flow Chem., 2015, 5(3), 145-147

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A flow-based transition-metal-catalysed hydrogenolysis strategy to facilitate peptide side-chain deprotection

Menti-Platten, M. et al.; Org. Biomol. Chem., 2022, 20, 106-112

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A flow chemistry route to 2-phenyl-3-(1H-pyrrol-2-yl)propan-1-amines

Tarleton, M.; McCluskey, A.; Tetrahedron Letters, 2011, 52(14), 1583-1586

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A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.; Chem. Commun., 2006, 2566-2568

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A flow process using microreactors for the preparation of a quinolone derivative as a potent 5HT1B antagonist

Qian, Z.; Baxendale, I. R.; Ley, S. V.; Synlett, 2010, 4, 505-508

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A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K.; Chem. Commun., 2006, 4835-4837

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A gram-scale batch and flow total synthesis of perhydrohistrionicotoxin

Brasholz, M.; Macdonald, J. M.; Saubern, S.; Ryan, J. H.; Holmes, A. B.; Chem. Eur. J., 2010, 16(37), 11471-11480

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A Green Process for the Preparation of Bis(2,2,2-trifluoroethyl) Methylphosphonate

Molnar, K. et al.; Org. Process Res. Dev., 2017, 21, 1985-1989

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A method to identify best available technologies (BAT) for hydrogenation reactors in the pharmaceutical industry

Van Le Doan, T.; Stavarek, P.; de Bellefon, C.; J. Flow Chem., 2012, 2(3), 77-82

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A modular synthesis of teraryl‐based α‐helix mimetics, part 2: Synthesis of 5‐pyridine boronic acid pinacol ester building blocks with amino acid side chains in 3‐position

Peters, M.; Trobe, M.; Breinbauer, R.; Chem. Eur. J., 2013, 19(7), 2450-2456

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A multi-step continuous flow synthesis of pomalidomide

Ivanova, M. et al.; J. Flow Chem., 2022, https://doi.org/10.1007/s41981-022-00223-3

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A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands

Petersen, T. P.; Ritzen, A.; Ulven, T.; Org. Lett., 2009, 11(22), 5134-5137

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A novel agonist of the type 1 lysophosphatidic acid receptor (LPA1), UCM-05194, shows efficacy in neuropathic pain amelioration

Gonzalez Gil, I.; Zian, D.; Vazquez-Villa, H.; Hernandez-Torres, G.; Martinez, R. F.; Khiar-Fernandez, N.; Rivera, R.; Kihara, Y.; Devesa, I.; Mathivanan, S.; Rosell del Valle, C.; Zambrana-Infantes, E.; Puigdomenech, M.; Cincilla, G.; Sanchez-Martinez, M.; Rodriguez de Fonseca, F.; Ferrer-Montiel, A.; Chun, J.; Lopez-Vales, R.; Lopez-Rodriguez, M. L.; Ortega-Gutierrez, S.; J. med. Chem., 2019, accepted manuscript

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A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells

Kim, J.; Moon, S. H.; Kim, B. T.; Chae, C. H.; Lee, J. Y.; Kim, S. H.; PLoS One, 2014, 9(10), e110180

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A novel method for high-throughput reduction of compounds through automated sequential injection into a continuous-flow microfluidic reactor

Jones, R.; Godorhazy, L.; Szalay, D.; Gerencser, J.; Dorman, G.; Urge, L.; Darvas, F.; QSAR Comb. Sci., 2005, 24(6), 722-727

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A practical and benign synthesis of amines through Pd@mpg-C3N4 catalyzed reduction of nitriles

Li, Y.; Gong, Y.; Xu, X.; Zhang, P.; Li, H.; Wang, Y.; Catalysis Communications, 2012, 28, 9-12

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A remote-controlled adaptive medchem lab: an innovative approach to enable drug discovery in the 21st Century

Godfrey, A. G.; Masquelin, T.; Hemmerle, H.; Drug Discovery Today, 2013, 18(17-18), 795-802

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A safe and selective method for reduction of 2-nitrophenylacetic acid systems to N-aryl hydroxamic acids using continuous flow hydrogenation

Ichire, O.; Jans, P.; Parfenov, G.; Dounay, A. B.; Tetrahedron Letters, 2017, 58(6), 582-585

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A scalable two-step continuous flow synthesis of nabumetone and related 4-aryl-2-butanones

Viviano, M.; Glasnov, T. N.; Reichard, B.; Tekautz, B.; Kappe, C. O.; Org. Process Res. Dev., 2011, 15, 858-870

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A simple chemical model for clathrate hydrate inhibition by polyvinylcaprolactam

Davenport, J. R.; Musa, O. M.; Paterson, M. J.; Piepenbrock, M. O. M.; Fucke, K.; Steed, J. W.; Chem. Commun., 2011, 47, 9891-9893

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A simple, efficient, and selective deuteration via a flow chemistry approach

Mandity, I. M.; Martinek, T. A.; Darvas, F.; Fulop, F.; Tetrahedron Letters, 2009, 50, 4372-4374

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A small footprint oxycodone generator based on continuous flow technology and real-time analytics

Sommer, F. et al.; J. Flow Chem., 2021, 11, 707-715

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A stereoselective, catalytic strategy for the in-flow synthesis of advanced precursors of rasagiline and tamsulosin

Brenna, D.; Pirola, M.; Raimondi, L.; Burke, A. J.; Benaglia, M.; Bioorg. Med. Chem., 2017, 25(23), 6242-6247

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A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors

Gordon, C. P.; Dalton, N.; Vandegraaff N.; Deadman, J.; Rhodes, D. I.; Coates, J. A.; Pyne, S. G.; Griffith, R.; Bremner, J. B.; Keller, P. A.; Tetrahedron, 2018, 74(12), 1253-1268

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A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir

Dalla-Vechia, L.; Reichart, B.; Glasnov, T. N.; Miranda, L. S. M.; Kappe, C. O.; de Souza, R. O. M. A.; Org. Biomol. Chem., 2013, 11, 6806-6813

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A ‘turn-on’ fluorescence glycosyl dithiocarbamate probe for selective fluoride sensing in aqueous medium

Das, R.; Mishra, B.; Mukhopadhyay, B.; Synlett, 2018, 29(15), 2001-2005

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A two‐step continuous‐flow synthesis of N‐(2‐aminoethyl)acylamides through ring‐opening/hydrogenation of oxazolines

Gutmann, B.; Roduit, J. P.; Roberge, D.; Kappe, C. O.; Chem. Eur. J., 2011, 17, 13146-13150

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A versatile biobased continuous flow strategy for the production of 3-butene-1,2-diol and vinyl ethylene carbonate from erythritol

Tshibalonza, N. N.; Gerardy, R.; Alsafra, Z.; Eppe, G.; Monbaliu, J-C. M.; Green Chem., 2018, 20, 5147-5157

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A versatile de novo synthesis of legionaminic acid and 4-epi-legionaminic acid starting from D-serine

Gintner, M.; Yoneda, Y.; Schmölzer, C.; Denner, C.; Kahlig, H.; Schmid, W.; Carbohydrate Research, 2019, 474, 34-42

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A Warburg effect targeting vector designed to increase the uptake of compounds by cancer cells demonstrates glucose and hypoxia dependent uptake

Glenister, A.; Simone, M. I.; Hambley, T. W.; PLos One, 2019, online article

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Access to optically active 3‐aminopiperidines by ring expansion of prolinols: Thermodynamic versus kinetic control

Cochi, A. ; Pardo, D. G.; Cossy, J.; Eur. J. Org. Chem., 2012, 2012(10), 2023-2040

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Accessing novel process windows in a high‐temperature/pressure capillary flow reactor

Razzaq, T.; Glasnov, T. N.; Kappe, C. O.; Chem. Eng. Technol., 2009, 32(11), 1702-1716

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Activity of continuous flow synthesized Pd-based nanocatalysts in the flow hydroconversion of furfural

Garcia-Olmo, A. J.; Yepez, A.; Balu, A. M.; Prinsen, P.; Garcia, A.; Maziere, A.; Len, C.; Luque, R.; Tetrahedrom, 2017, 73(38), 5599-5604

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Acylguanidine beta secretase 1 inhibitors: a combined experimental and free energy perturbation study

Keranen, H.; Perez-Benito, L.; Ciordia, M.; Delgado, F.; Steinbrecher, T. B.; Oehlrich, D.; van Vlijmen, H. W. T.; Trabanco, A. A.; Tresadern, G.; J. Chem. Theory Comput., 2017, 13, 1439-1453

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Adaptive and automated system-optimization for heterogeneous flow-hydrogenation reactions

Fabry, D. C.; Heddrich, S.; Sugiono, E.; Liauw, M. A.; Rueping, M.; React. Chem. Eng., 2019, 4, 1486-1491

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Additive manufacturing technologies: 3D printing in organic synthesis

Rossi, S.; Puglisi, A.; Banglia, M.; ChemCatChem, 2018, 10(7), 1512-1525

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Advanced Real-Time Process Analyticsfor Multistep Synthesis in Continuous Flow

Sagmeister, P. et al.; Angew. Chem. Int. Ed., 2021, 60, 8139-8148

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Aerobic flow oxidation of alcohols in water catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

Osako, T.; Torii, K.; Uozumi, Y.; RSC Adv., 2015, 5, 2647-2654

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Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries

Gavriilidis, A. et al.; React. Chem. Eng., 2016, 1, 595-612

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Alkyne–azide cycloadditions with copper powder in a high‐pressure continuous‐flow reactor: High‐temperature conditions versus the role of additives

Otvos, S. B.; Mandity, I. M.; Kiss, L.; Fulop, F.; Chem. Asian J., 2013, 8(4), 800-808

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Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitor

Ponomarev, K. Yu.; Suslov, E. V.; Zakharenko, A. L.; Zakharova, O. D.; Rogachev, A. D.; Korchagina, D. V.; Zafar, A.; Reynisson, J.; Nefedov, A. A.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I.; Bioorg. Chem., 2018, 76, 392-399

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Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization

Whelligan, D. K.; Solanki, S.; Taylor, D.; Thomson, D. W.; Cheung, K. J.; Boxall, K.; Mas-Droux, C.; Barillari, C.; Burns, S.; Grummitt, C. G.; Collins, I.; van Montfort, E. L. M.; Aherne, G. W.; Bayliss, R.; Hoelder, S.; J. Med. Chem., 2010, 53, 7682-7698

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An alternative route for fondaparinux sodium synthesis via selective hydrogenations and sulfation of appropriate pentasaccharides

Manikowski, A.; Koziol, A.; Czajkowska-Wojciechowska, E.; Carbohydrate Research, 2012, 361, 155-161

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An efficient and more sustainable one-step continuous-flow multicomponent synthesis approach to chromene derivatives

Vaddula, B. R.; Yalla, S.; Gonzalez, M. A.; J. Flow Chem., 2015, 5(3), 172-177

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An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process

Sedelmeier, J.; Ley, S. V.; Baxendale, I. R.; Green Chem., 2009, 11, 683-685

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An efficient continuous flow approach to furnish furan-based biaryls

Trinh, T. N.; Hizartzidis, L.; Lin, A. J. S.; Harman, D. G.; McCluskey, A.; Gordon, C. P.; Org. Biomol. Chem., 2014, 12, 9562-9571

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An imidazolium-based organopalladium-functionalized organic–inorganic hybrid silica promotes one-pot tandem Suzuki cross coupling–reduction of haloacetophenones and arylboronic acids

Zhang, D.; Cheng, T.; Liu, G.; Applied Catal. B: Environmental, 2015, 174-175, 344-349

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An Integrated Continuous-Flow Synthesis of a Key Oxazolidine Intermediate to Noroxymorphone from Naturally Occurring Opioids

Mata, A. et al.; Eur. J. Org. Chem., 2017, 6505-6510

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An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor

Russell, C.; Lin, A. J. S.; Hains, P.; Simone, M. I.; Robinson, P. J.; McCluskey, A.; RSC Adv., 2015, 5, 93433-93437

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An orally bioavailable, indole-3-glyoxylamide based series of tubulin polymerization inhibitors showing tumor growth inhibition in a mouse xenograft model of head and neck cancer

Colley, H. E.; Muthana, M.; Danson, J. S.; Jackson, L. V.; Brett, M. L.; Harrison, J.; Coole, S. F.; Mason, D. P.; Jennings, L. R.; Wong, M.; Tulasi, V.; Noraman, D.; Lockey, P. M.; Williams, L.; Dossetter, A. G.; Griffen, E. J.; Thompson, M. J.; J. Med. Chem., 2015, 58(23), 9309-9333

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Application of continuous flow and alternative energy devices for 5-hydroxymethylfurfural production

Schon, M.; Schnurch, M.; Mihovilovic, M. D.; Mol. Divers., 2011, 15, 639-643

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Application of deuterated THENA for assigning the absolute configuration of chiral secondary alcohols

Soponpong, J.; Dolsophon, K.; Thongpanchang, C.; Linden, A.; Thongpanchang, T.; Tetrahedron Letters, 2019, 60(6), 497-500

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Application of factorial design of experiments for the continuous hydrogenation of enriched castor oil methyl esters

Neeharika, T. S. V. R.; Rani, K. N. P.; Rao, K. V. S. A.; Kumar, T. P.; Prasad, R. B. N.; Bulletin of Chemical Reaction Engineering & Catalysis, 2013, 8(2), 154-159

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Application of metal‐based reagents and catalysts in microstructured flow devices

Chinnusamy, T.; Yudha S. S.; Hager, M.; Kreitmeier, P.; Reisen, O.; ChemSusChem, 2012, 5(2), 247-255

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Applying flow chemistry: Methods, materials, and multistep synthesis

McQuade, D. T.; Seeberger, P. H.; J. Org. Chem., 2013, 78(13), 6384-6389

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Approaches for Performing Reductions under Continuous-Flow Conditions

Neyt, N. C. et al.; Synthesis, 2018, 50(14), 2707-2720

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Approaches to pyranuronic β-sugar amino acid building blocks of peptidosaccharide foldamers

Goldschmidt-Goz, V.; Pinter, I.; Harmat, V.; Perczel, A.; Eur. J. Org. Chem., 2018, 3, 355-361

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Aqueous flow hydroxycarbonylation of aryl halides catalyzed by an amphiphilic polymer-supported palladium–diphenylphosphine catalyst

Osako, T.; Kaiser, R.; Torii, K.; Uozumi, Y.; Synlett, 2019, 30, 961-966

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Assessing a sustainable manufacturing route to lapatinib

Stark, R. T. et al.; React. Chem. Eng., 2022, Advance article

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Assignment of vibrational circular dichroism cross‐referenced electronic circular dichroism spectra of flexible foldamer building blocks: Towards assigning pure chiroptical properties of foldamers

Farkas, V.; Nagy, A.; Menyhard, D. K.; Perczel, A.; Chem. Eur. J., 2019, 25(65), 14890-14900

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Asymmetric aldol reaction in a continuous-flow reactor catalyzed by a highly reusable heterogeneous peptide

Otvos, S. B.; Mandity, I. M.; Fulop, F.; J. Cat., 2012, 295, 179-185

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Asymmetric hydrogenation of C=C double bonds using Rh-complex under homogeneous, heterogeneous and continuous mode conditions

Balogh S.; Farkas, G.; Madarasz, J.; Szollosy, A.; Kovacs, J.; Darvas, F.; Urge L.; Bakos, J.; Green Chem., 2012, 14, 1146-1151

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Asymmetric Mannich reaction of dicarbonyl compounds with α-amido sulfones catalyzed by cinchona alkaloids and synthesis of chiral dihydropyrimidones

Lou, S.; Dai, P.; Schaus, S. E.; J. Org. Chem., 2007, 72, 9998-10008

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Asymmetric organocatalytic Michael addition–cyclisation cascade of cyclopentane-1,2-dione with alkylidene malononitriles

Silm, E.; Kaabel, S.; Jarving, I.; Kanger, T.; Synthesis, 2019, 51, 4198-4204

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Asymmetric Synthesis of γ-Amino-Functionalised Vinyl Sulfones: De Novo Preparation of Cysteine Protease Inhibitors

Shen, W. et al.; Synthesis, 2022, 54(7), 1753-1764

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Asymmetric Total Synthesis of (-)-Erogorgiaene and Its C-11 Epimer and Investigation of Their Antimycobacterial Activity

Incerti-Pradillos, C. A. et al.; Chem. Eur. J., 2016, 22, 14390-14396

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Atomic Cu on nanodiamond-based sp2/sp3 hybrid nanostructures for selective hydrogenation of phenylacetylene

Sun, Y.; Luo, B.; Xu, S.; Guo, W.; Huang, X.; Shao, L.; Chemical Physics Letters, 2019, 723, 39-43

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Automated and continuous synthesis of drug substances

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Automated flow and real-time analytics approach for screening functional group tolerance in heterogeneous catalytic reactions

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Automated technology for performing flow chemistry at elevated temperature and pressure

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Aziridine ring opening for the synthesis of sphingolipid analogues: Inhibitors of sphingolipid-metabolizing enzymes

Alcaide, A.; Llebaria, A.; J. Org. Chem., 2014, 79(7), 2993-3029

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Batch and flow hydrotreatment of water contaminated by trichloroethylene on active carbon supported nickel catalysts

Kaminska, I. I.; Kowalewski, E.; Lisovytskiy, D.; Blachucki, W.; Rarog-Pilecka, W.; Lomot, D.; Srebowata, A.; Applied Catalysis A: General, 2019, 582, 117110

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Batch versus continuous flow performance of supported mono‐ and bimetallic nickel catalysts for catalytic transfer hydrogenation of furfural in isopropanol

Wang, Y.; Prinsen, P.; Triantafyllidis, K. S.; Karakoulia, S. A.; Yepez, A.; Len, C.; Luque, R.; ChemCatChem, 2018, 10(16), 3459-3468

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Batch‐ and Continuous‐Flow Aerobic Oxidation of 14‐Hydroxy Opioids to 1,3‐Oxazolidines—A Concise Synthesis of Noroxymorphone

Gutmann, B. et al.; Chem. Eur. J., 2016, 22, 10393-10398

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Benchmarking immobilized di- and triarylphosphine palladium catalysts for continuous-flow cross-coupling reactions: Efficiency, durability, and metal leaching studies

Greco, R.; Goessler, W.; Cantillo, D.; Kappe, C. O.; ACS Catal., 2015, 5, 1303-1312

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Benign-by-design orange peel-templated nanocatalysts for continuous flow conversion of levulinic acid to N-heterocycles

Rodriguez-Padron, D.; Puente-Santiago, A. R.; Balu, A. M.; Romero, A. A.; Munoz-Batista, M. J.; Luque, R.; ACS Sustainable Chem. Eng., 2018, 6(12), 16637-16644

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Benzo[d]imidazole transient receptor potential vanilloid 1 antagonists for the treatment of pain: Discovery of trans-2-(2-{2-[2-(4-trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

Parsons, W. H.; Calvo, R. R.; Cheung, W.; Lee, Y. K.; Patel, S.; Liu, J.; Youngman, M. A.; Dax, S. L.; Stone, D.; Qin, N.; Hutchinson, T.; Lubin, M. L.; Zhang, S. P.; Finley, M.; Liu, Y.; Brandt, M. R.; Flores, C. M.; Player, M. R.; J. Med. Chem., 2015, 58(9), 3859-3874

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Benzoxazinone synthesis via Passerini–Smiles couplings

Martinand-Lurin, E.; El Kaim, L.; Grimaud, L.; Tetrahedron Letters, 2014, 55(37), 5144-5146

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Benzoxazolone carboxamides as potent acid ceramidase inhibitors: Synthesis and structure–activity relationship (SAR) studies

Bach, A.; Pizzirani, D.; Realini, N.; Vozella, V.; Russo, D.; Penna, I.; Melzig, L.; Scarpelli, R.; Piomelli, D.; J. Med. Chem., 2015, 58(23), 9258-9272

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Beyond electrolysis: old challenges and new concepts of electricity-driven chemical reactors

Nigar, H. et al.; React. Chem. Eng., 2020, 5, 1005

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Beyond the use of modifiers in selective alkyne hydrogenation: silver and gold nanocatalysts in flow mode for sustainable alkene production

Vile, G.; Perez-Ramirez, J.; Nanoscale, 2014, 6, 13476-13482

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Bicyclic naphthenic acids in oil sands process water: Identification by comprehensive multidimensional gas chromatography–mass spectrometry

Wilde, M. J.; West, C. E.; Scarlett, A. G.; Jones, D.; Frank, R. A.; Hewitt, L. M.; Rowland, S. J.; Journal of Chromatography A, 2015, 1378, 74-87

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Bifunctional Ruthenium Nanoparticle-SILP Catalysts (RuNPs@SILP) for the Hydrodeoxygenation of Eucalyptol under Batch and Continuous Flow Conditions

Luska, K. L. et al.; ACS Sustainable Chem. Eng., 2016, 4(11), 6186-6192

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Biocatalyzed Flow Oxidation of Tyrosol to Hydroxytyrosol and Efficient Production of Their Acetate Esters

Annunziata, F. et al.; Antioxidants, 2021, 10(7), 1142

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Bis(diethylamino)(pentafluorophenyl)phosphane – a push–pull phosphane available for coordination

Orthaber, A.; Fuchs, M.; Belaj, F.; Rechberger, G. N.; Kappe, C. O.; Pietschnig, R.; Eur. J. Inorg. Chem., 2011, 2588-2596

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Boosting the Productivity of H2-Driven Biocatalysis in a Commercial Hydrogenation Flow Reactor Using H2 From Water Electrolysis

Poznansky, B. et al.; Front. Chem. Eng., 2021, 3, 718257

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Build−Couple−Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity

Uguen, M. et al.; J. Med. Chem., 2022, Advance article

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Building β-peptide H10/12 foldamer helices with six-membered cyclic side-chains: Fine-tuning of folding and self-assembly

Mandity, M. I.; Fulop, L.; Vass, E.; Toth; G. K.; Martinek, T. A.; Fulop, F.; Organic Letters, 2010, 12(23), 5584-5587

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C-3 epimers of sugar amino acids as foldameric building blocks: improved synthesis, useful derivatives, coupling strategies

Nagy, A.; Csordas, B.; Zsoldos-Mady, V.; Pinter, I.; Farkas, V.; Perczel, A.; Amino acids, 2017, 49(2), 223-240

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Can two‐dimensional gas chromatography/mass spectrometric identification of bicyclic aromatic acids in petroleum fractions help to reveal further details of aromatic hydrocarbon biotransformation pathways?

West, C. E.; Pureveen, J.; Scarlett, A. G.; Lengger, S. K.; Wilde, M. J.; Korndorffer, F.; Tegelaar, E. W.; Rowland, S. J.; Rapid Commun. Mass Spectrom., 2014, 28(9), 1023-1032

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Carbonylation in microflow: close encounters of CO and reactive species

Fukuyama, T.; Totoki, T.; Ryu, I.; Green Chemistry, 2014, 16, 2042-2050

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Catalysis in flow: Au-catalysed alkylation of amines by alcohols

Zotova, N.; Robert, F. J.; Kelsall, G. H.; Jessiman, A. S.; Hellgardt, K.; Hii, K. K.; Gree Chem., 2012, 14, 226-232

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Catalysis in flow: the practical and selective aerobic oxidation of alcohols to aldehydes and ketones

Zotova, N.; Hellgardt, K.; Kelsall, G. H.; Jessiman, A. S.; Hii, K. K.; Green Chem., 2010, 12, 2157-2163

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Catalytic asymmetric crotylation of aldehydes: Application in total synthesis of (−)‐elisabethadione

O’Hora, P. S.; Incerti‐Pradillos, C. A.; Kabeshov, M. A.; Shipilovskikh, S. A.; Rubtsov, A. E.; Elsegood, M. R. J; Malkov, A. V.; Chem. Eur. J., 2015, 21(12), 4551-4555

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Catalytic epoxidation of cyclohexene with tert-butylhydroperoxide using an immobilized molybdenum catalyst

Morales-delaRosa, S.; Campos-Martin, J. M.; Terreros, P.; Fierro, J. L. G.; Topics in Catalysis, 2015, 58, 325-333

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Catalytic hydrogenolysis of substituted diaryl ethers by using ruthenium nanoparticles on an acidic supported ionic liquid phase (Ru@SILP-SO3H)

Rengshausen, S.; Etscheidt, F.; Großkurth, J.; Luska, K. L.; Bordet, A.; Leitner, W.; Synlett, 2019, 30(4), 405-412

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Catalytic oxidation of aqueous bioethanol: an efficient upgrade from batch to flow

Mostrou, S.; Sipocz, T.; Nagl, A.; Fodi, B.; Darvas, F.; Fottinger, K.; van Bokhoven, J. A.; React. Chem. Eng., 2018, 3, 781-789

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Catalytically sustainable, palladium-decorated graphene oxide monoliths for synthesis in flow

Ghobadi, S.; Burkholder, M. B.; Smith, S. E.; Gupton, B. F.; Castano, C. E.; Chem. Eng. J., 2020, 381, 122598

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Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

Gallagher, C. M.; Garri, C.; Cain, E. L.; Ang, K. K. H.; Wilson, C. G.; Chen, S.; Hearn, B. R.; Jaishankar, P.; Aranda-Diaz, A.; Arkin, M. R.; Renslo, A. R.; Walter, P.; eLife, 2016, 5, e:11878

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Characterization of dispersion effects on reaction optimization and scale-up for a packed bed flow hydrogenation reactor

Eschelbach, J. W.; Wernick, D.; Bryan, M. C.; Doherty, E. M.; Aust. J. Chem., 2013, 66, 165-171

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Chemical and bacterial reduction of azo-probes: monitoring a conformational change using fluorescence spectroscopy

Rattray, N. J. W.; Zalloum, W. A.; Mansell, D.; Latimer, J.; Jaffar, M.; Bichenkova, E. V.; Freeman, S.; Tetrahedron, 2013, 69, 2758-2766

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Chemical assembly systems: Layered control for divergent, continuous, multistep syntheses of active pharmaceutical ingredients

Ghislieri, D.; Gilmore, K.; Seeberger, P. H.; Angew. Chem. Int. Ed., 2014, 54(2), 678-682

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Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Rossetti, I.; Compagnoni, M.; Chemical Engineering Journal, 2016, 296, 56-70

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Chemical synthesis of a tetrasaccharide related to the exocellular polysaccharide from Rhodococcus sp. RHA1

Budhadev, D.; Mukhopadhyay, B.; Carbohydrate Research, 2014, 394, 26-31

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Chemical synthesis of the 4-amino-4,6-dideoxy-d-glucose containing pentasaccharide repeating unit of the O-specific polysaccharide from Aeromonas hydrophila strain K691 in the form of its 2-aminoethyl glycoside

Adak, A.; Mukhopadhyay, B.; Carbohydrate Research, 2019, 476, 1-7

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Chemical synthesis of the pentasaccharide related to the repeating unit of the O-Antigen from Salmonella enterica O4

Das, R.; Mukhopadhyay, B.; Journal of Carbohydrate Chemistry, 2015, 34(5), 247-262

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Chemical synthesis of the pentasaccharide repeating unit of the O-specific polysaccharide from Escherichia coli O132 in the form of its 2-aminoethyl glycoside

Pal, D.; Mukhopadhyay, B.; Beilstein J. Org. Chem., 2019, 15, 2563-2568

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Chemical synthesis of the pentasaccharide repeating unit of the O-specific polysaccharide from Ruminococcus gnavus

Pal, D. et al.; Carbohydrate Research, 2021, 507, 108384

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Chemical synthesis of the rare D-Fuc3NAc containing tetrasaccharide repeating unit of the O-antigenic polysaccharide from E. coli O74

Bera, A. et al.; Carbohydrate Research, 2021, 506, 108366

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Chemistry of 3-carbonyl-2-methyl-4-oxo-4H-1-benzopyrans

Ghosh, C. K.; Chakraborty, A.; ARKIVOC, 2016, 2016(1), 111-149

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Chemistry of pyrrolizidine alkaloids revisited – semi-synthetic microwave and continuous-flow approaches toward Crotalaria-alkaloids

Martineza, S. T.; Pinto, A. C.; Glasnov, T.; Kappe, C. O.; Tetrahedron Letters, 2014, 55(30), 4181-4184

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Chemo-Catalyzed Pathways to Lactic Acid and Lactates

Shuklov, I. A. et al.; Adv. Synth. Catal., 2016, 358, 3910-3931

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Chemo-enzymatic synthesis of 13C labeled complex N-glycans as internal standards for the absolute glycan quantification by mass spectrometry

Echeverria, B.; Etxebarria, J.; Ruiz, N.; Hernandez, A.; Calvo, J.; Haberger, M.; Reusch, D.; Reichardt, N-C.; Analytical Chemistry, 2015, 87(22), 11460-11467

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Chemoenzymatic Synthesis in Flow Reactors: A Rapid and Convenient Preparation of Captopril

De Vitis, V. et al.; ChemistryOpen, 2017, 6, 668-673

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Chemoselective flow hydrogenation approaches to diversify the cytotoxic tetrahydroepoxyisoindole carboxamide scaffold

Spare, L. K.; Harman, D. G.; Aldrich-Wright, J. R.; Nguyen, T. V.; Gordon, C. P.; Adv. Synth. Catal., 2018, 360(6), 1209-1217

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Chemoselective flow hydrogenation approaches to isoindole-7-carboxylic acids and 7-oxa-bicyclio[2.2.1]heptanes

Hizartzidis, L.; Tarleton, M.; Gordon, C. P.; McCluskey, A.; RSC Adv., 2014, 4, 9709-9722

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Chiral auxiliary recycling in continuous flow: automated recovery and reuse of Oppolzer’s sultam

Sullivan, R. J.; Newman, S. G.; Chemical Science, 2018, 9, 2130-2134

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CIS is a potent checkpoint in NK cell–mediated tumor immunity

Delconte, R. B. et al.; Nat. Immun., 2016, 17, 816-824

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Co Loading Adjustment for the Effective Obtention of a Sedative Drug Precursor through Efficient Continuous-Flow Chemoselective Hydrogenation of 2-Methyl-2-Pentenal

Fernandez-Ropero, A. J. et al.; Catalysts, 2022, 12, 19

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Cobalt-doped magnesium fluoride as a support for platinum catalysts: The correlation of surface acidity with hydrogenation activity

Pietrowski, M.; Zieliński, M.; Alwina, E.; Gulaczyk, I.; Przekop, R. E.; Wojciechowska, M.; J. Cat., 2019, 378, 298-311

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Combining enabling techniques in organic synthesis: continuous flow process with heterogenized catalysts

Kirschning, A.; Solodenko, W.; Mennecke, K.; Chem. Eur. J., 2006, 12(23), 5972-5990

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Combining microfluidics and FT-IR spectroscopy: towards spatially resolved information on chemical processes

Perro, A. et al.; React. Chem. Eng., 2016, 1, 577-594

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Comparative Study of Supported Monometallic Catalysts in the Liquid-Phase Hydrogenation of Furfural: Batch Versus Continuous Flow

Wang, Y. et al.; ACS Sustainable Chem. Eng., 2018, 6, 8, 9831-9844

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Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling

Baer, S.; Nigro, J.; Madej, M. P.; Nisbet, R. M.; Suryadinata, R.; Coia, G.; Hong, L. P. T.; Adams, T. E.; Williams, C. C.; Nuttall, S. D.; Org. Biomol. Chem., 2014, 12, 2675-2685

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Concise chemical synthesis of the pentasaccharide repeating unit of the O-antigen from Escherichia albertii O2

Bera, M.; Adak, A.; Mukhopadhyay, B.; Carbohydrate Research, 2019, 485, 107817

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Concise synthesis of a tetra- and a trisaccharide related to the repeating unit of the O-antigen from Providencia rustigianii O34 in the form of their p-methoxyphenyl glycosides

Verma, P. R.; Mukhopadhyay, B.; RSC Adv., 2013, 3, 201-207

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Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxidation

Chassagne, P.; Raibaut, L.; Guerreiro, C.; Mulard, L. A.; Tetrahedron, 2013, 69(48), 10337-10350

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Concise synthesis of the trisaccharide repeating unit of the O-polysaccharide from Aeromonas hydrophila A19 (O:14)

Pal, K. B.; Mukhopadhyay, B.; Carbohydrate Research, 2013, 379, 26-29

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Concise synthesis of vesnarinone and its analogues by using Pd‐catalyzed C–N bond‐forming reactions

See, Y. Y.; Dang, T. T.; Chen, A.; Seayad, A. M.; Eur. J. Org. Chem., 2014, 7405-7412

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Construction and validation of an automated flow hydrogenation instrument for application in high-throughput organic chemistry

Clapham, B.; Wilson, N. S.; Michmerhuizen, M. J.; Blanchard, D. P.; Dingle, D. M.; Nemcek, T. A.; Pan, J. Y.; Sauer, D. R.; J. Comb. Chem., 2008, 10, 88-93

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Construction of a bicyclic β-benzyloxy and β-hydroxy amide library through a multicomponent cyclization reaction

Zhang, L.; Xiao, Q.; Ma, C.; Xie, X.; Floreancig, P. E.; J. Comb. Chem., 2009, 11(4), 640-644

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Continuous enantioselective hydrogenation of activated ketones on a Pt-CD chiral catalyst: Use of H-Cube reactor system

Szollosi, G.; Herman, B.; Fulop, F.; Bartok, M.; React. Kinet. Catal. Lett., 2006, 88(2), 391-398

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Continuous enzymatic stirred tank reactor cascade with unconventional medium yielding high concentrations of (S)-2-hydroxyphenyl propanone and its derivatives

Oeggl, R. et al.; Catal. Sci. Technol., 2021, 11, 7886-7897

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Continuous flow alcoholysis of furfuryl alcohol to alkyl levulinates using zeolites

Zhao, D.; Prinsen, P.; Wang, Y.; Ouyang, W.; Delbecq, F.; Len, C.; Luque, R.; ACS Sustainable Chem. Eng., 2018, 6(5), 6901-6909

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Continuous flow biocatalysis

Britton, J.; Majumdar, S.; Weiss, G. A.; Chem. Soc. Rev., 2018, 47, 5891-5918

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Continuous-flow biochemical reactors: Biocatalysis, bioconversion, and bioanalytical applications utilizing immobilized microfluidic enzyme reactors

Hajba, L.; Guttman, A.; J. Flow Chem., 2016, 6(1), 8-12

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Continuous-flow catalytic deuterodehalogenation carried out in propylene carbonate

Mandity, I. M.; Fulop, F.; Orsy, G.; Green Chemistry, 2019, 21, 956-961

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Continuous-flow catalytic hydrogenation of 3a,6-epoxyisoindoles

Zaytsev, V. P.; Zubkov, F. I.; Mertsalov, D. F.; Orlova, D. N.; Sorokina, E. A.; Nikitina, E. V.; Varlamov, A. V.; Russian Chemical Bulletin, 2015, 64, 112-126

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Continuous flow conversion of alkyl levulinates into γ-valerolactone in the presence of Ru/C as catalyst

Zhao, D.; Wang, Y.; Delbecq, F.; Len, C.; Molecular Catalysis, 2019, 475, 110456

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Continuous flow conversion of biomass-derived methyl levulinate into γ-valerolactone using functional metal organic frameworks

Ouyang, W.; Zhao, D.; Wang, Y.; Balu, A. M.; Len, C.; Luque, R.; ACS Sustainable Chem. Eng., 2018, 6(5), 6746-6752

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Continuous-flow enzymatic resolution strategy for the acylation of amino alcohols with a remote stereogenic centre: synthesis of calycotomine enantiomers

Schonstein, L.; Forro, E.; Fulop, F.; Tetrahedron: Asymmetry, 2013, 24, 202-206

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Continuous flow fabrication of block copolymer–grafted silica micro‐particles in environmentally friendly water/ethanol media

Ye, P.; Cao, P-F.; Chen, Q.; Advincula, R.; Macromol. Mater. Eng., 2018, 1800451

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Continuous-flow high pressure hydrogenation reactor for optimization and high-throughput synthesis

Jones, R. V.; Godorhazy, L.; Varga, N.; Szalay, D.; Urge, L.; Darvas, F.; J. Comb. Chem., 2006, 8(1), 110-116

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Continuous-flow hydrogenation of D-xylose with bimetallic ruthenium catalysts on micrometric alumina

Paun, C.; Lewin, E.; Sa, J.; iMedPub., 2017

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Continuous flow hydrogenation of functionalized pyridines

Irfan, M.; Petricci, E.; Glasnov, T. N.; Taddei, M.; Kappe, C. O.; Eur. J. Org. Chem., 2009, 9, 1327-1334

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Continuous flow hydrogenation of nitroarenes, azides and alkenes using maghemite–Pd nanocomposites

Rathi, A. K.; Gawande, M. B.; Ranc, V.; Pechousek, J.; Petr, M.; Cepe, K.; Varma, R. S.; Zboril, R.; Catal. Sci. Technol., 2016, 6, 152-160

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Continuous flow hydrogenation of nitroarenes, azides and alkenes using maghemite-Pd nanocomposites

Rathi, A. K. et al.; Catal. Sci. Technol., 2016, 6, 152-160

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Continuous-flow hydrogenation of nitrocyclohexane toward value-added products with CuZnAl hydrotalcite derived materials

Kowalewski, E. et al.; Applied Catalysis A, General, 2021, 618, 118134

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Continuous-flow hydrogenation of olefins and nitrobenzenes catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

Osako, T.; Torii, K.; Tazawa, A.; Uozumi, Y.; RSC Adv., 2015, 5, 45760-45766

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Continuous flow hydrogenation with Pd complexes of pyridine-benzotriazole ligands

Yilmaz, F. et al.; Appl. Organomet. Chem., 2021, 35(11), e6389

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Continuous flow (micro-)reactors for heterogeneously catalyzed reactions: Main design and modelling issues

Rossetti, I.; Catalysis Today, 2018, 308, 20-31

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Continuous-flow microreactor chemistry under high-temperature/pressure conditions

Razzaq, T.; Glasnov, T. N.; Kappe, C. O.; Eur. J. Org. Chem., 2009, 9, 1321-1325

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Continuous flow multi-step organic synthesis

Webb, D.; Jamison, T. F.; Chemical Science, 2010, 6, 675-680

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Continuous flow nanocatalysis: reaction pathways in the conversion of levulinic acid to valuable chemicals

Bermudez, J. M.; Menendez, J. A.; Romero, A. A.; Serrano, E.; Garcia-Martinez, J.; Luque, R.; Green Chem., 2013, 15(10), 2786-2792

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Continuous flow organic chemistry: successes and pitfalls at the interface with current societal challenges

Gerardy, R.; Emmanuel, N.; Toupy, T.; Kassin, V-E.; Tshibalonza, N. N.; Schmitz, M.; Monbaliu, J-C. M.; Eur. J. Org. Chem., 2018, 2018(20-21), 2301-2351

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Continuous-flow organic synthesis: a tool for the modern medicinal chemist

Wiles, C.; Watts, P.; Future Med. Chem., 2009, 1(9), 1593-1612

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Continuous flow organic synthesis under high-temperature/pressure conditions

Razzaq, T.; Kappe, C. O.; Chem. Asian J., 2010, 5(6), 1274-1289

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Continuous flow ozonolysis in a laboratory scale reactor

Irfan, M.; Glasnov, T. N.; Kappe, C. O.; Organic Letters, 2011, 13(5), 984-987

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Continuous-flow Pd-catalyzed carbonylation of aryl chlorides with carbon monoxide at elevated temperature and pressure

Mata, A.; Hone, C. A.; Gutmann, B.; Moens, L.; Kappe, C. O.; ChemCatChem, 2018, 11(3), 997-1001

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Continuous-flow processes in heterogeneously catalyzed transformations of biomass derivatives into fuels and chemicals

Serrano-Ruiz, J. C.; Luque, R.; Campelo, J. M.; Romero, A. A.; Challenges, 2012, 3, 114-132

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Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients

de Souza, R. O. M. A.; Aguiar, R.; Leao, R. A. C.; Miranda, L. S. N.; Kappe, C. O.; Cantillo, D.; Mata, A.; Org. Biomol. Chem., 2019, 17, 1552-1557

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Continuous flow reactors: a perspective

Wiles, C.; Watts, P.; Green Chem., 2012, 14, 38-54

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Continuous flow Reductive Alkylation of Methanol by Aldehydes. Synthesis of O-Methyl Ethers and 1,1-Dimethoxyacetals

Radjagobalou, R. et al.; Mol. Cat., 2022, 524, 112321

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Continuous-flow reductive alkylation: synthesis of bio-based symmetrical and disymmetrical ethers

Bruniaux, S.; Luart, D.; Len, C.; Synthesis, 2018, 50, 1849-1856

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Continuous Flow retro-Diels-Alder Reaction: A Novel Process Window for Designing New Heterocyclic Scaffolds

Nekkaa, I. et al.; Eur. J. Org. Chem., 2018, 2018(32), 4456-4464

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Continuous flow room temperature reductive aqueous homo-coupling of aryl halides using supported Pd catalysts

Feiz, A.; Bazgir, A.; Balu, A. M.; Luque, R.; Sci. Rep., 2016, 6, Article number: 32719

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Continuous flow selective hydrogenation of 5-hydroxymethylfurfural to 2,5-dimethylfuran using highly active and stable Cu-Pd/reduced graphene oxide

Mhadmhan, S.; Franco, A.; Pineda, A.; Reubroycharoen, P.; Luque, R.; ACS Sustainable Chem. Eng., 2019, 7(16), 14210-14216

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Continuous flow study of isoeugenol to vanillin: A bio-based iron oxide catalyst

Filiciotto, L. et al.; Catalysis Today, 2021, 368, 281-90

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Continuous-flow syntheses of heterocycles

Glasnov, T. N.; Kappe, C. O.; J. Heterocyclic Chem., 2011, 48, 11-30

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Continuous flow synthesis. A pharma perspective

Malet-Sanz, L.; Susanne, F.; J. Med. Chem., 2012, 55(9), 4062-4098

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Continuous Flow Synthesis of a Key 1,4-Benzoxazinone Intermediate via a Nitration/Hydrogenation/Cyclization Sequence

Cantillo, D. et al.; Org. Process Res. Dev., 2017, 21, 125-132

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Continuous flow synthesis of amines from the cascade reactions of nitriles and carbonyl-containing compounds promoted by Pt-modified titania catalysts

Altug, C. et al.; Green Chemistry, 2019, 21, 300-306

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Contiuous-flow synthesis of deuterium-labeled antidiabetic chalcones: studies towards the selective deuteration of the alkynone core

Otvos, S. B.; Hsieh, C. T.; Wu, Y. C.; Li, J. H.; Chang, F. R.; Fulop, F.; Molecules, 2016, 21(3), 318-329

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Continuous Flow Synthesis of High Valuable N-Heterocycles via Catalytic Conversion of Levulinic Acid

Rodriguez-Padron, D. et al.; Front. Chem., 2019, 7, 103

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Continuous flow synthesis of menthol via tandem cyclisation-hydrogenation of citronellal catalysed by scrap catalytic converters

Zuliani, A.; Cova, C. M.; Manno, R.; Sebastian, V.; Romero, A. A.; Luque, R.; Green Chemistry, 2020, 22, 379-387

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Continuous-flow synthesis of primary amines: Metal-free reduction of aliphatic and aromatic nitro derivatives with trichlorosilane

Porta, R. et al.; Beilstein J. Org. Chem., 2016, 12, 2614-2619

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Continuous-flow synthesis of thermochromic M-Phase VO2 particles via rapid one-step hydrothermal reaction: Effect of mixers

Yan, X.; Trevillyan, W.; Castano, I.; Sun, Y.; Muehleisen, R.; Li, J.; Journal of Nanomaterials, 2019, 2019, 2570698

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Continuous flow transfer hydrogenation of biomass derived methyl levulinate over Zr containing zeolites: Insights into the role of the catalyst acidity

Cabanillas, M.; Franco, A.; Lazaro, N.; Balu, A. M.; Luque, R.; Pineda, A.; Mol. Cat., 2019, 477, 110522

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Continuous reductive amination of biomass-derived molecules over carbonized filter paper-supported FeNi alloy

Chieffi, G.; Braun, M.; Esposito, D.; ChemSusChem, 2015, 8(21), 3590-3594

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Continuous‐flow hydrogenation and reductive deuteration of nitriles: a simple access to α,α‐dideutero amines

Meszaros, R.; Peng, B.; Otvos, S. B.; Yang, S.; Fulop F.; ChemPlusChem, 2019, 84(10), 1508-1511

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Controlled photo-flow oxidative reaction (UV-FOR) platform for ultra-fast phthalides and API synthesis

Aand, D. et al.; Green Chemistry, 2018, 20, 4584-4590

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Convergent synthesis of the hexasaccharide related to the repeating unit of the O-antigen from E. coli O120

Budhadev, D.; Mukhopadhyay, B.; RSC Adv., 2015, 5, 98033-98040

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Convergent synthesis of the hexasaccharide repeating unit of the O-antigenic OPS of Escherichia coli O133

Mitra, A.; Mukhopadhyay, B.; Eur. J. Org. Chem., 2019, 2019(30), 4869-4878

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Copper-catalyzed rearragement of oximes into primary amides

Sharma, S. K.; Bishopp, S. D.; Allen, C. L.; Lawrence, R.; Bamford, M. J.; Lapkin, A. A.; Plucinski, P.; Watson, R. J.; Williams, J. M .J.; Tetrahedron Letters, 2011, 52, 4252-4255

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Copper-zinc oxide interface as a methanol-selective structure in Cu-ZnO catalyst during catalytic hydrogenation of carbon dioxide to methanol

Saedy, S. et al.; Catal. Sci. Technol., 2022, 12, 2703-2716

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Covalently immobilized Trp60Cys mutant of ω-transaminase from Chromobacterium violaceum for kinetic resolution of racemic amines in batch and continuous-flow modes

Abahazi, E.; Satorhelyi, P.; Erdelyi, B.; Vertessy, B. G.; Land, H.; Paizs, C.; Berglund, P.; Poppe, L.; Biochem. Eng. J., 2018, 132, 270-278

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Cross-coupling in flow

Noel, T.; Buchwald, S. L.; Chem. Soc. Rev., 2011, 40, 5010-5029

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Cubanes in medicinal chemistry: Synthesis of functionalized building blocks

Wlochal, J.; Davies, R. D. M.; Burton, J.; Org. Lett., 2014, 16, 4094-4097

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De novo design of a picomolar nonbasic 5-HT1B receptor antagonist

Nugiel, D. A.; Krumrine, J. R.; Hill, D. C.; Damewood, J. R.; Bernstein, P. R.; Sobotka-Briner, C. D.; Liu, J. W.; Zacco, A.; Pierson, M. E.; J. Med. Chem., 2010, 53, 1876-1880

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De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments

Urich, R.; Wishart, G.; Kiczun, M.; Richters, A.; Tidten-Luksch, N.; Rauh, D.; Sherborne, B.; Wyatt, P. G.; Brenk, R.; ACS Chem. Biol., 2013, 8(5), 1044-1052

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De novo design, synthesis and pharmacological evaluation of new azaindole derivatives as dual inhibitors of Abl and Src kinases

Cheve, G.; Bories, C.; Fauvel, B.; Picot, F.; Tible, A.; Dayde-Cazals, B.; Loget, O.; Yasri, A.; Med. Chem. Commun., 2012, 3, 788-800

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Densely substituted L-proline esters as catalysts for asymmetric Michael additions of ketones to nitroalkenes

Ruiz-Olalla, A.; de Gracia Retamosa, M.; Cossio, F. P.; J. Org. Chem., 2015, 80(11), 5588-5599

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Design and development of Pd-catalyzed aerobic N-demethylation strategies for the synthesis of noroxymorphone in continuous flow mode

Gutmann, B.; Cantillo, D.; Weigl, U.; Cox, P.; Kappe, C. O.; Eur. J. Org. Chem., 2017, 914-927

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Design and development of photoswitchable DFG-Out RET kinase inhibitors

Grotli, M. et al.; Eur. J. Med. Chem., 2022, 234, 114226

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Design and Scaling Up of Microchemical Systems: A Review

Zhang, J. et al.; Ann. Rev. Chem. Biomol. Eng., 2017, 8, 285-305

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Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist

Clarke, E.; Jarvis, C. I.; Goncalves, M. B.; Kalindjian, S. B.; Adams, D. R.; Brown, J. T.; Shiers, J. J.; Taddei, D. M. A.; Ravier, E.; Barlow, S.; Miller, I., Smith, V.; Borthwick, A. D.; Corcoran, J. P. T.; Bioorg. Med. Chem., 2018, 26(4), 798-814

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Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119

Darout, E.; Robinson, R. P.; McClure, K. F.; Corbett, M.; Li, B.; Shavnya, A.; Andrews, M. P.; Jones, C. S.; Li, Q.; Minich, L. M.; Mascitti, V.; Guimaraes, C. R. W.; Munchhof, M. J.; Bahnck, K. B.; Cai, C.; Price, D. A.; Liras, S.; Bonin, P. D.; Cornelius, P.; Wang, R.; Bagdasarian, V.; Sobota, C. P.; Hornby, S.; Masterson, V. M.; Joseph, R. M.; Kalgutkar, A. S.; Chen, Y.; J. Med. Chem., 2013, 56, 301-319

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Design and synthesis of multivalent α-1,2-trimannose-linked bioerodible microparticles for applications in immune response studies of Leishmania major infection

Rintelmann, C. R.; Grinnage-Pulley, T.; Ross, K.; Kabotso, D. E. K.; Toepp, A.; Cowell, A.; Petersen, C.; Narasimhan, B.; Pohl, N.; Beilstein J. Org. Chem., 2019, 15, 623-632

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Design of a highly selective and potent class of non-planar estrogen receptor ß agonists

Sunden, H.; Ma, J. N.; Hansen, L. K.; Gustavsson, A. L.; Burstein, E. S.; Olsson, R.; ChemMedChem, 2013, 8(8), 1283-1294

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Design of experiments (DoE) and process optimization. A review of recent publications

Weissman, S. A.; Anderson, N. G.; Org. Process Res. Dev., 2015, 19(11), 1605-1633

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Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists

Cho, K.; Ando, M.; Kobayashi, K.; Miyazoe, H.; Tsujino, T.; Ito, S.; Suzuki, T.; Tanaka, T.; Tokita, S.; Sato, N.; Bioorg. Med. Chem. Lett., 2009, 19(16), 4781-4785

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Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators

Pettersson, M.; Johnson, D. S.; Subramanyam, C.; Bales, K. R.; am Ende, C. W.; Fish, B. A.; Green, M. E.; Kauffman, G. W.; Mullins, P. B.; Navaratnam, T.; Sakya, S. M.; Stiff, C. M.; Tran, T. P.; Xie, L.; Zhang, L.; Pustilnik, L. R.; Vetelino, B. C.; Wood, K. M.; Pozdnyakov, N.; Verhoest, P. R.; O'Donnell, C. J.; J. Med. Chem., 2014, 57, 1046-1062

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Development of biolubricants from vegetable oils via chemical modification

McNutt, J.; He, Q.; J. Ind. Eng. Chem., 2016, 36, 1-12

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Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors

Lawrence, H. R.; Martin, M. P.; Luo, Y.; Pireddu, R.; Yang, H.; Gevariya, H.; Ozcan, S.; Zhu, J. Y.; Kendig, R.; Rodriguez, M.; Elias, R.; Cheng, J. Q.; Sebti, S. M.; Schonbrunn, E.; Lawrence, N. J.; J. Med. Chem., 2012, 55(17), 7392-7416

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Development of second-generation indole-based dynamin GTPase inhibitors

Gordon, C. P.; Venn-Brown, B.; Robertson, M. J.; Young, K. A.; Chau, N.; Mariana, A.; Whiting, A.; Chircop, M.; Robinson, P. J.; McCluskey, A.; J. Med. Chem., 2013, 56, 46-59

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Diacylglycerol synthesis by lipase-catalyzed partial hydrolysis of palm oil under microwave irradiation and continuous flow conditions

Matos, L. M. C.; Leal, I. C. R.; de Souza, R. O. M. A.; Journal of Molecular Catalysis B: Enzymatic, 2011, 72, 36-39

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Diastereoselective 1,3-dipolar cycloaddition of pyrylium ylides with chiral enamides

Tchabanenko, K.; Sloan, C.; Bunetel, Y.; Mullen, P.; Org. Bioorg. Chem., 2012, 10, 4215-4219

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Diastereoselective [2,3]-sigmatropic rearrangement of N-allyl ammonium ylides

Murre, A.; Erkman, K.; Kaabel, S.; Jarving, I.; Kanger, T.; Synthesis, 2019, 51(22), 4183-4197

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Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assembly

Carter, C. F.; Lange, H.; Sakai, D.; Baxendale I. R.; Ley, S. V.; Chem. Eur. J., 2011, 17, 3398-3405

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Diastereoselective synthesis of cis-N-Boc-4-aminocyclohexanol with reductive ring opening method using continuous flow

Szabo, B.; Tamas, B.; Faigl, F.; Eles, J.; Greiner, I.; J. Flow Chem., 2019, 9(1), 13-17

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Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars

Bergeron-Brlek, M.; Meanwell, M.; Britton, R.; Nature Communications, 2015, 6, 6303

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Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Z.; Pinson, J. A.; Mountford, S. J.; Orive, S.; Schoenwaelder, S. M.; Shackleford, D.; Powell, A.; Nelson, E. M.; Hamilton, J. R.; Jackson, S. P.; Jennings, I. G.; Thompson, P. E.; Eur. J. Med. Chem., 2016, 122, 339-351

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Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase

Cummings, M. D.; Lin, T.; Hu, L.; Tahri, A.; McDowan, D.; Amssoms, K.; Last, S.; Devogelaere, B., Rouan, M.; Vijgen, L., Berke, J. M.; Dehertogh, P.; Fransen, E.; Cleiren, E.; van der Helm, L.; Fanning, G.; Nyanguile, O.; Simmen, K.; Remoortere, P. V.; Raboisson, P.; Vendeville, S., J. Med. Chem., 2014, 57(5), 1880-1892

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Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design

Efremov, I. V.; Vajdos, F. F.; Borzilleri, K. A.; Capetta, S.; Chen, H.; Dorff, P. H.; Dutra, J. K.; Goldstein, S. W.; Mansour, M.; McColl, A.; Noell, S.; Oborski, C. E.; O'Connell, T. N.; O'Sullivan, T. J.; Pandit, J.; Wang, H.; Wei, B.; Withka, J. M.; J. Med. Chem., 2012, 55(21), 9069-9088

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Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2

Zak, M.; Mendonca, R.; Balazs, M.; Barrett, K.; Bergeron, P.; Blair, W. S.; Chang, C.; Deshmukh, G.; DeVoss, J.; Dragovich, P. S.; Eigenbrot, C.; Ghilardi, N.; Gibbons, P.; Gradl, S.; Hamman, C.; Hanan, E.; Harstad, E.; Hewitt, P. R.; Hurley, C. A.; Jin, T.; Johnson, A.; Johnson, T.; Kenny, J. R.; Koehler, M. F. T.; Kohli, P. B.; Kulagowski, J.; Labadie, S.; Liao, J.; Liimatta, M.; Lin, Z.; Lupardus, P. J.; Maxey, R. J.; Murray, J. M.; Pulk, R.; Rodriguez, M.; Savage, S.; Shia, S.; Steffek, M.; Ubhayakar, S.; Ultsch, M.; Van-Abbema, A.; Ward, S.; Xiao, L.; Xiao, Y.; J. Med. Chem., 2012, 55(13), 6176-6193

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Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

Phillipson, L. J.; Segal, D. H.; Nero, T. L.; Parker, M. W.; Wan, S. S.; de Silva, M.; Guthridge, M. A.; Wei, A. H.; Burns, C. J.; Bioorg. Med. Chem., 2015, 23(19), 6280-6296

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Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)

Martin-Martin, M. L.; Bartolome-Nebreda, J. M.; Conde-Ceide, S.; Alonso de Diego, S. A.; Lopez, S.; Martinez-Viturro, C. M.; Tong, H. M.; Lavreysen, H.; Macdonald, G. J.; Steckler, T.; Mackie, C.; Bridges, T. M.; Daniels, J. S.; Niswender, C. M.; Noetzel, M. J.; Jones, C. K.; Conn, P. J.; Lindsley, C. W.; Stauffer, S. R.; Bioorg. Med. Chem. Lett., 2015, 25(6), 1310-1317

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Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors

Ge, Y.; Kazi, A.; Marsilio, F.; Luo, Y.; Jain. S.; Brooks, W.; Daniel, K. G.; Guida, W. C.; Sebti, S. M.; Lawrence, H. R.; J. Med. Chem., 2012, 55(5), 1978-1998

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Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation

Giordanetto, F.; Wallberg, A.; Cassel, J.; Ghosal, S.; Kossenjans, M.; Yuan, Z. Q.; Wang, X.; Liang, L.; Bioorg. Med. Chem. Lett., 2012, 22, 6665-6670

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Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)

Axten, J. M.; Medina, J. R.; Feng, Y.; Shu, A.; Romeril, S. P.; Grant, S. W.; Li, W. H. H.; Heerding, D. A.; Minthorn, E.; Mencken, T.; Atkins, C.; Liu, Q.; Rabindran, S.; Kumar, R.; Hong, X.; Goetz, A.; Stanley, T.; Taylor, J. D.; Sigethy, S. D.; Tomberlin, G. H.; Hassell, A. M.; Kahler, K. M.; Shewchuk, L. M.; Gampe, R. T.; J. Med. Chem., 2012, 55(16), 7193-7207

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Discovery of a new class of highly potent inhibitors of acid ceramidase: Synthesis and structure–activity relationship (SAR)

Pizzirani, D.; Pagliuca, C.; Realini, N.; Branduardi, D.; Bottegoni, G.; Mor, M.; Bertozzi, F.; Scarpelli, R.; Piomelli, D.; Bandiera, T.; J. Med. Chem., 2013, 56(9), 3518-3530

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Discovery of a novel chemotype of histone lysine methyltransferase EHMT1/2 (GLP/G9a) inhibitors: rational design, synthesis, biological evaluation and cocrystal structure

Milite, C.; Feoli, A.; Horton, J. R.; Rescigno, D.; Cipriano, A.; Pisapia, V.; Viviano, M.; Pepe, G.; Amendola, G.; Novellino, E.; Cosconati, S.; Cheng, X.; Castellano, S.; Sbardella, G.; J. Med. Chem., 2019, 62(5), 2666-2689

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Discovery of a novel inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) as orally active antitumor agent

Vianello, P.; Botrugno, O. A.; Cappa, A.; Zuffo, R. D.; Dessanti, P.; Mai, A.; Marrocco, B.; Mattevi, A.; Meroni, G.; Minucci, S.; Stazi, G.; Thaler, F.; Trifiro, P.; Valente, S.; Villa, M.; Mercurio, C.; J. Med. Chem., 2016, 59(4), 1501-1517

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Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours

Barlaam, B.; Cosulich, S.; Degorce, S.; Ellston, R.; Fitzek, M.; Green, S.; Hancox, U.; Lambert-van der Brempt, C.; Lohmann, J-J.; Maudet, M.; Morgentin, M.; Ple, P.; Ward, L.; Warin, N.; Bioorg. Med. Chem. Lett., 2017, 27(9), 1949-1954

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Discovery of acrylonitrile-based small molecules active against Haemonchus contortus

Gordon, C. P.; Hizartzidis, L.; Tarleton, M.; Sakoff, J. A.; Gilbert, J.; Campbell, B. E.; Gasser, R. B.; McCluskey, A.; Med. Chem. Commun., 2014, 5, 159-164

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Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models

Patel, S.; Cohen, F.; Dean, B. J.; De La Torre, K.; Deshmukh, G.; Estrada, A. A.; Ghosh, A. S.; Gibbons, P.; Gustafson, A.; Huestis, M. P.; Le Pichon, C. E.; Lin, H.; Liu, W.; Liu, X.; Liu, Y.; Ly, C. Q.; Lyssikatos, J. P.; Ma, C.; Scearce-Levie, K.; Shin, Y. G.; Solanoy, H.; Stark, K. L.; Wang, J.; Wang, B:; Zhao, X.; Lewcock, J. W.; Siu, M.; J. Med. Chem., 2015, 58(1), 401-418

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Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor

Giordanetto, F.; Wallberg, A.; Knerr, L.; Selmi, N.; Ullah, V.; Thorstensson, F.; Lindelof, L.; Karlsson, S.; Nikitidis, G.; Llinas, A.; Wang, Q. D.; Lindqvist, A.; Hogberg, L.; Lindhardt, E.; Astrand, A.; Duker, G.; Bioorg. Med. Chem. Lett., 2013, 23(1), 119-124

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Discovery of narrow spectrum kinase inhibitors: New therapeutic agents for the treatment of COPD and steroid-resistant asthma

Onions, S. T.; Ito, K; Charron, C. E.; Brown, R. J.; Colucci, M.; Frickel, F.; Hardy, G.; Joly, K.; King-Underwood, J.; Kizawa, Y.; Knowles, I.; Murray, P. J.; Novak, A.; Rani, A.; Rapeport, G.; Smith, A.; Strong, P.; Taddei, D. M.; Williams, J. G.; J. Med. Chem., 2016, 59(5), 1727-1746

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Discovery of potent and selective inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) protein kinase as potential anticancer agents

Charrier, J. D.; Durrant, S. J.; Golec, J. M. C.; Kay, D. P., Knegtel, R. M. A.; MacCormick, S.; Mortimore, M.; O'Donnell, M. E.; Pinder, J. L.; Reaper, P. M.; Rutherford, A. P.; Wang, P. S. H.; Young, S. C.; Pollard, J. R.; J. Med. Chem., 2011, 54(7), 2320-2330

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Discovery of potent and selective reversible Bruton’s tyrosine kinase inhibitors

Qiu, H. et al.; Bioorg. Med. Chem., 2021, 40, 116163

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Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux

Rzasa, R. M.; Hu, E.; Rumfelt, S.; Chen, N.; Andrews, K. L.; Chmait, S.; Falsey, J. R.; Zhong, W.; Jones, A. D.; Porter, A.; Louie, S. W.; Zhao, X.; Treanor, J. J. S.; Allen, J. R.; Bioorg. Med. Chem. Lett., 2012, 22, 7371-7375

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Discovery of tertiary amine and indole derivatives as potent RORγt inverse agonists

Yang, T.; Liu, Q.; Cheng, Y.; Cai, W.; Ma, Y.; Yang, L.; Wu, Q.; Orband-Miller, L. A.; Zhou, L.; Xiang, Z.; Huxdorf, M.; Zhang, W.; Zhang, J.; Xiang-J-N.; Leung, S.; Qiu, Y.; Zhong, Z.; Elliott, J. D.; Lin, X.; Wang, Y.; ACS Med. Chem. Lett., 2014, 5(1), 65-68

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Dissection of complex molecular recognition interfaces

Hunter, C. A.; Misuraca, M. C.; Turega, S. M.; J. Am. Chem. Soc., 2011, 133(3), 582-594

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Disubstituted 1-aryl-4-aminopiperidine library synthesis using computational drug design and high-throughput batch and flow technologies

Bryan, M. C.; Hein, C. D.; Gao, H.; Xia, X.; Eastwood, H.; Bruenner, B. A.; Louie, S. W.; Doherty, E. M; ACS Comb. Sci., 2013, 15(9), 503-511

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Diversity-oriented synthesis of a library of star-shaped 2H-imidazolines

Yu, X.; Guttenberger, N.; Fuchs, E.; Peters, M.; Weber, H.; Breinbauer R.; ACS Comb. Sci., 2015, 17(11), 682-690

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Diversity-oriented synthesis of dibenzoazocines and dibenzoazepines via a microwave-assisted intramolecular A3-coupling reaction

Bariwal, J. B.; Ermolat'ev, D. S.; Glasnov, T. N.; Van Hecke, K.; Mehta, V. P.; Van Meervelt, L.; Kappe, C. O.; Van der Eycken, E. V.; Org. Lett., 2010, 12(12), 2774-2777

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Doping carbon networks with phosphorus for supporting Pd in catalyzing selective oxidation of benzyl alcohol

Guo, W.; Niu, S.; Ji, X.; Yu, W.; Lin, T-W.; Wu, Y.; Li, Y.; Shao, L.; J. Nanopart. Res.; 2018, 20:180

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Double carbonylation of iodobenzene in a microfluidics-based high throughput flow reactor

Balogh, J.; Kuik, A.; Urge, L.; Darvas, F.; Bakos, J.; Skoda-Foldes, R.; Journal of Molecular Catalysis A: Chemical, 2009, 302, 76-79

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Easy access to Ni3N- and Ni-carbon nanocomposite catalysts

Clavel, G.; Molinari, V.; Kraupner, A.; Giordano, C.; Chem. Eur. J., 2014, 20(29), 9018-9023

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Eco-efficiency analysis for intensified production of an active pharmaceutical ingredient: a case study

Dencic, I.; Ott, D.; Kralisch, D.; Noel, T.; Meuldijk, J.; de Croon, M.; Hessel, V.; Laribi, Y.; Perrichon, P.; Org. Process Res. Dev., 2014, 18(11), 1326-1338

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Effects of Regioisomerism on the Antiproliferative Activity of Hydroxystearic Acids on Human Cancer Cell Lines

Boga, C. et al.; Molecules, 2022, 27, 2396

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Efficient and scalable synthesis of thiazole fused benzazepine as a D2 partial agonist

Xiong, H.; Wu, Y.; Lehr, S. G.; Blackwell, W.; Steelman, G.; Hulsizer, J.; Urbanek, R. A.; Tetrahedron Letters, 2012, 53(44), 5833-5836

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Efficient continuous-flow synthesis of novel 1,2,3-triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production

Otvos, S. B.; Georgiades, A.; Mandity, I. M.; Kiss, L.; Fulop, F.; Beilstein J. Org. Chem., 2013, 9, 1508-1516

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Efficient Ru-based scrap waste automotive converter catalysts for the continuous-flow selective hydrogenation of cinnamaldehyde

Cova, C. M. et al.; Green Chemistry, 2019, 21, 4712-4722

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Electrochemical Hydroxylation of Electron-Rich Arenes in Continuous Flow

Kooli, A et al.; Eur. J. Org. Chem., 2022, 20, e202200011

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Electrochemical phenylselenoetherification as a key step in the synthesis of (±)-curcumene ether

Stevanovic, D.; Pejovic, A.; Damljanovic, I. S.; Vukicevic, M. D.; Dobrikov, G.; Dimitrov, V.; Denic, M. S.; Radulovic, N. S.; Vukicevic, R. D.; Helvetica Chimica Acta, 2013, 96(6), 1103-1110

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Electrophile-induced dearomatizing spirocyclization of N-arylisonicotinamides: A route to spirocyclic piperidines

Arnott, G.; Brice, H.; Clayden, J.; Blaney, E.; Organic Letters, 2008, 10(14), 3089-3092

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Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4)

Day, J. P.; Lindsay, B.; Riddel, T.; Jiang, Z.; Allock, R. W.; Abraham, A.; Sookup, S.; Christian, F.; Bogum, J.; Martin, E. K.; Rae, R. L.; Anthony, D.; Rosair, G. M.; Houslay, D. M.; Huston, E.; Baillie, G. S.; Klussmann, E.; Houslay, M. D.; Adams, D. R.; J. Med. Chem., 2011, 54(9), 3331-3347

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Emerging trends in flow chemistry and applications to the pharmaceutical industry

Bogdan, A. R.; Dombrowski, A. W.; J. Med. Chem., 2019, 62(14), 6422-6468

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Enabling the scale-up of a key asymmetric hydrogenation step in the synthesis of an API using continuous flow solid-supported catalysis

Amara, Z.; Poliakoff, M.; Duque, R.; Geier, D.; Francio, G.; Gordon, C. M.; Meadows, R. E.; Woodward, R.; Leitner, W.; Org. Process Res. Dev., 2016, 20, 1321-1327

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Enantiodivergent synthesis of bis-spiropyrrolidines via sequential interrupted and completed (3+2) cycloadditions

Conde, E.; Rivilla, I.; Larumbe, A.; Cossio F. P.; J. Org. Chem., 2015, 80(23), 11755-11767

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Enantiomer selective acylation of racemic alcohols by lipases in continuous-flow bioreactors

Csajagi, Cs.; Szatzker, G.; Toke, E. R.; Urge, L.; Darvas, F.; Poppe, L.; Tetrahedron: Asymmetry, 2008, 19(2), 237-246

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Enantiomeric separation of bicyclo[2.2.2]octane‐based 2‐amino‐3‐carboxylic acids on macrocyclic glycopeptide chiral stationary phases

Pataj, Z.; Ilisz, I.; Grecso, N; Palko, M.; Fulop, F.; Armstrong, D. W.; Peter, A.; Chirality, 2014, 26, 200-208

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Enantioselective access to benzannulated spiroketals using a chiral sulfoxide auxiliary

Aitken, H. R. M.; Furkert, D. P.; Hubert, J. G.; Wood, J. M.; Brimble, M. A.; Org. Biomol. Chem., 2013, 11, 5147-5155

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Enantioselective hydrogenation of α,β-unsaturated carboxylic acids in fixed-bed reactor

Herman, B.; Szollosi, G.; Fulop F.; Bartok, M.; Applied Catalysis A: General, 2007, 331, 39-43

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Enantioselective hydrolysis of 3,4-disubstituted β-lactams. An efficient enzymatic method for the preparation of a key Taxol side-chain intermediate

Galla, Zs.; Beke, F.; Forro, E.; Fulop, F.; Journal of Molecular Catalysis B: Enzymatic, 2016, 123, 107-112

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Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary

Jones, A. L.; Liu, X.; Snyder, J. K.; Tetrahedron Letters, 2010, 51(7), 1091-1094

Link to article

Enantioselective synthesis of bicyclo[2.2.2]octenones using a copper-mediated oxidative dearomatization/[4+2] dimerization cascade

Dong, S.; Zhu, J.; Porco, J. A.; J. Am. Chem. Soc., 2008, 130(9), 2738-2739

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Enantioselective synthesis of (+)-Chamaecypanone C: A novel microtubule inhibitor

Dong, S.; Hamel, E.; Bai, R.; Covell, D. G.; Beutler, J. A.; Porco, J .A.; Angew. Chem. Int. Ed., 2009, 48(8), 1494-1497

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endo-Hydroxamic acid monomers for the assembly of a suite of non-native dimeric macrocyclic siderophores using metal-templated synthesis

Brown, C. J. M.; Gotsbacher, M. P.; Holland, J. P.; Codd, R.; Inorg. Chem., 2019, 58(20), 13591-13603

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Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction

Liu, Q.; Wu, K.; Cheng, Y.; Lu, L.; Xiao, E.; Zhang, Y.; Deng, Z.; Liu, T.; Metabolic Engineering, 2015, 28, 82-90

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Enhanced biocatalytic performance of bacterial laccase from Streptomyces sviceus: Application in the Michael addition sequence towards 3‐arylated 4‐oxochromanes

Suljic, S.; Mortzfeld, F. B.; Gunne, M.; Urlacher, V. B.; Pietruszka, J.; ChemCatChem, 2015, 7(8), 1380-1385

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Environmentally friendly synthesis of indoline derivatives using flow-chemistry techniques

Orkenyi, R.; Beke, G.; Riethmuller, E.; Szakacs, Z.; Koti, J.; Faigl, F.; Eles, J.; Greiner, I.; Eur. J. Org. Chem., 2017, 6525-6532

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Enzymatic reactions for the preparation of homocalycotomine enantiomers

Schonstein, L.; Forro, E.; Fulop, F.; Tetrahedron: Asymmetry, 2013, 24, 1059-1062

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Enzymatic strategy for the resolution of new 1‐hydroxymethyl tetrahydro‐β‐carboline derivatives in batch and continuous‐flow systems

Megyesi, R.; Forro, E.; Fulop, F.; ChemistryOpen, 2016, 5(3), 254-260

Link to article

Epoxy resin monomers with reduced skin sensitizing potency

O'Boyle, N. M.; Niklasson, I. B.; Tehrani-Bagha, A. R.; Delaine, T.; Holmberg, K.; Luthman, K.; Karlberg, A. T.; Chem. Res. Toxicol., 2014, 27(6), 1002-1010

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Evaluating dynamic kinetic resolution strategies in the asymmetric hydrosilylation of cyclic ketimines

Jones, S.; Zhao, P.; Tetrahedron: Asymmetry, 2014, 25(3), 238-244

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Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis

Bryan, M. C.; Wernick, D.; Hein, C. D.; Petersen, J. V.; Eschelbach, J. W.; Doherty, E. M.; Beilstein J. Org. Chem., 2011, 7, 1141-1149

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Evaluation of bifunctional chiral phosphine oxide catalysts for the asymmetric hydrosilylation of ketimines

Warner, C. J. A.; Berry, S. S.; Jones, S.; Tetrahedron, 2019, accepted manuscript

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Evaluation of functional groups as acetyl-lysine mimetics for BET bromodomain inhibition

Sharp, P. P.; Garnier, J-M.; Huang, D. C. S.; Burns, C. J.; MedChemCommun, 2014, 5, 1834-1842

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Evaluation of SILP-Pd catalysts for Heck reactions in amicrofluidics-based high throughput flow reactor

Urban, B.; Sranko, D.; Safran, G.; Urge, L.; Darvas, F.; Bakos, J.; Skoda-Foldes, R.; Journal of Molecular Catalysis A: Chemical, 2014, 395, 364-372

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Expanding the toolbox of asymmetric organocatalysis by continuous-flow process

Finelli, F. G.; Miranda, L. S. M.; de Souza, R. O. M. A.; Chem. Commun., 2015, 51, 3708-3722

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Expanding the utility of flow hydrogenation – a robust protocol restricting hydrodehalogenation

Hizartzidis, L.; Cossar, P. J.; Robertson, M. J.; Simone, M. I.; Young, K. A.; McCluskey, A.; Gordon, C. P.; RSC Adv., 2014, 4, 56743-56748

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Expedient Diels–Alder cycloadditions with ortho-quinodimethanes in a high temperature/pressure flow reactor

Tsoung, J.; Wang, Y.; Djuric, S. W.; React. Chem. Eng., 2017, 2, 458-461

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Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a]pyridine: expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines

Bazin, M. A.; Marhadour, S.; Tonnerre, A.; Marchand, P.; Tetrahedron Letters, 2013, 54(39), 5378-5382

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Facile access to new C-glycosides and C-glycoside scaffolds incorporating functionalised aromatic moieties

Redpath, P.; Ness, K. A.; Rousseau, J.; Macdonald, S. J. F.; Migaud, M. E.; Carbohydrate Research, 2015, 402, 25-34

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Facile arene hydrogenation under flow conditions catalyzed by rhodium or ruthenium on carbon

Hattori, T.; Ida, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Eur. J. Org. Chem., 2015, 2015(11), 2492-2497

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Facile conversion of red phosphorus into soluble polyphosphide anions by reaction with potassium ethoxide

Dragulescu-Andrasi, A.; Miller, L. Z.; Chen, B.; McQuade, D. T.; Shatruk M.; Angew. Chem. Int. Ed., 2016, 55(12), 3904-3908

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Fast continuous alcohol amination employing a hydrogen borrowing protocol

Labes, R.; Mateos, C., Battilocchio, C.; Chen, Y.; Dingwall, P.; Cumming, G. R.; Rincon, J. A.; Nieves-Remacha, M. J.; Ley, S. V.; Green Chemistry, 2019, 21, 59-63

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Fatty acids residue from palm oil refining process as feedstock for lipase catalyzed monoacylglicerol production under batch and continuous flow conditions

Junior, I. I.; Flores, M. C.; Sutili, F. K.; Leite, S. G. F.; de M. e Miranda, L. S.; Leal, I. C. R.; de Souza, R. O. M. A.; Journal of Molecular Catalysis B: Enzymatic, 2012, 77, 53-58

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Features of oxa-bridge cleavage in hexahydro-3a,6-epoxyisoindol-1(4H)-ones: A concise method to access acetylisoindolones possessing anti-viral activity

Zaytsev, V. P.; Mertsalov, D. F.; Chervyakova, L. V.; Krishna, G.; Zubkov, F. I.; Dorovatovski, P. V.; Khrustalev, V. N.; Zarubaev, V. V.; Tetrahedron Lett., 2019, 60(43), 151204

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Feedback in Flow for Accelerated Reaction Development

Reizman, B. J. et al.; Acc. Chem. Res., 2016, 49(9), 1786-1796

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FeNi nanoparticles with carbon armor as sustainable hydrogenation catalysts: towards biorefineries

Chieffi, G.; Giordano, C.; Antonietti, M.; Esposito, D.; Journal of Materials Chemistry A, 2014, 2, 11591-11596

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Fine chemical syntheses under flow using SiliaCat catalysts

Ciriminna, R.; Pandarus, V.; Beland, F.; Pagliaro, M.; Catal. Sci. Technol., 2016, 6(13), 4678-4685

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First enantioselective total synthesis of (+)-(R)-pinnatolide using an symmetric domino allylation reaction

Tietze, L. F.; Wolfram, T.; Holstein, J. J.; Dittrich, B.; Org. Lett., 2012, 14(16), 4035-4037

Link to article

First example of alkyl–aryl Negishi cross-coupling in flow: Mild, efficient and clean introduction of functionalized alkyl groups

Egle, B.; Munoz, J.; Alonso, N.; De Borggraeve, W. M., de la Hoz, A.; Diaz-Ortiz, A.; Alcazar, J.; J. Flow Chem., 2014, 4(1), 22-25

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Fixed Bed Continuous Hydrogenations in Trickle Flow Mode: A Pharmaceutical Industry Perspective

Masson, E. et al.; Org. Process Res. Dev., 2022, Accepted manuscript

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Flash carboxylation: fast lithiation-carboxylation sequence at room temperature in continuous flow

Pieber, B.; Glasnov, T.; Kappe, C. O.; RSC Adv., 2014, 4, 13430-13433

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Flash flow pyrolysis: Mimicking flash vacuum pyrolysis in a high-temperature/high-pressure liquid-phase microreactor environment

Cantillo, D.; Sheibani, H.; Kappe, C. O.; J. Org. Chem., 2012, 77(5), 2463-2473

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Flow chemistry – A key enabling technology for (multistep) organic synthesis

Wegner, J.; Ceylan, S.; Kirschning, A.; Adv. Synth. Catal., 2012, 354, 17-57

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Flow chemistry approach for partial deuteration of alkynes: synthesis of deuterated taxol side chain

Chandrasekhar, S.; Vijaykumar, B. V. D.; Mahesh Chandra, B.; Raji Reddy, Ch.; Naresh, P.; Tetrahedron Letters, 2011, 52, 3865-3867

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Flow chemistry approaches directed at improving chemical synthesis

Baxendale, I. R.; Brocken, L.; Mallia, C. J.; Green Process. Synth., 2013, 2(3), 211-230

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Flow chemistry as a versatile tool for the synthesis of triazoles

Otvos, S. B.; Fulop, F.; Catal. Sci. Technol., 2015, 5(11), 4926-4941

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Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation

Mandity, I.; Fulop, F.; Nekka, I.; Bogdan, D.; Gati, T.; Beni, S.; Juhasz, T.; Palko, M.; Paragi, G.; Toth, G.; Chem. Commun., 2019, 55, 3061-3064

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Flow chemistry for designing sustainable chemical synthesis

Vaddula, B. R.; Gonzalez, M. A.; Chimica Oggi – Chemistry Today, 2013, 31, 16-20

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Flow Chemistry in Space – A Unique Opportunity to Perform Extraterrestrial Research

Sipos, G. et al.; J. Flow Chem., 2017, 7(3-4), 151-156

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Flow chemistry in the multi-step synthesis of natural products

Wan, L. et al.; Green Synth. Catal., 2022, Advance article

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Flow chemistry: Intelligent processing of gas-liquid transformations using a tube-in-tube reactor

Brzozowski, M.; O'Brien, M.; Ley, S. V.; Polyzos, A.; Acc. Chem. Res., 2015, 48(2), 349-362

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Flow chemistry syntheses of natural products

Pastre, J. C.; Browne, D. L.; Ley, S. V.; Chem. Soc. Rev., 2013, 42, 8849-8869

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Flow chemistry: Towards a more sustainable heterocyclic synthesis

Brandao, P.; Pineiro, M.; Pinho e Melo, T. M. V. D.; Eur. J. Org. Chem., 2019, 2019(43), 7188-7217

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Flow chemistry vs. flow analysis

Trojanowicz, M.; Talanta, 2016, 146, 621-640

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Flow fine synthesis with heterogeneous catalysts

Masuda, K.; Ichitsuka T.; Koumura, N.; Sato, K.; Kobayashi, S.; Tetrahedron, 2018, 74(15), 1705-1730

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Flow Hydrogenation of 1,3,5-Trinitrobenzenes over Cu-Based Catalysts as an Efficient Approach for the Preparation of Phloroglucinol Derivatives

Shchurova, I. A. et al.; Synthesis, 2022, https://doi.org/10.1055/a-1807-3188

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Flow hydrogenation of p-nitrophenol with nano-Ag/Al2O3

Paun, C.; Slowik, G.; Lewin, E.; Sa, J.; RSC Adv., 2016, 6, 87564-87568

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Flow-oriented synthetic design in the continuous preparation of the aryl piperazine drug flibanserin

Bana, P.; Szigetvari, A.; Koti, J.; Eles, J.; Greiner, I.; React. Chem. Eng., 2019, 4, 652-657

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Flow reactors for drug discovery flow for reaction optimization, library synthesis, and scale up

Jones, R. V.; Csajagi, Cs.; Szekelyhidi, Zs.; Kovacs, I.; Borcsek, B.; Urge, L.; Darvas, F.; Chemistry Today, 2008, 26(3), 10-13

Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe

Plutschack, M. B.; McQuade, D. T.; Valenti, G.; Seeberger, P. H.; Beilstein J. Org. Chem., 2013, 9, 2022-2027

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Flow synthesis of annulated 5-aryl-substituted pyridines by tandem intramolecular inverse-electron-demand hetero-/retro-Diels–Alder reaction

Martin, R. E.; Lenz, M.; Alzieu, T.; Aebi, J. D.; Forzy, L.; Tetrahedron Letters, 2013, 54(49), 6703-6707

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Flow Synthesis of Biologically-Relevant Compound Libraries

Navarro, P. M. L. et al.; Molecules, 2020, 25, 909

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Formation of benzocyclobutenes from substituted oxocycloocta-2,8-diene-1,2-dicarboxylates

Bezensek, J.; Groselj, U.; Pockaj, M.; Svete, J.; Stanovnik, B.; Tetrahedron Letters, 2015, 56(42), 5705-5708

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Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors

Saluste, G.; Albarran, M. I.; Alvarez, R. M.; Rabal, O.; Ortega, M. A.; Blanco, C.; Kurz, G.; Salgado, A.; Pevarello, P.; Bischoff, J. R.; Pastor, J.; Oyarzabal, J.; PLoS One, 2012, 7(10), e45964

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From the Lindlar catalyst to supported ligand‐modified palladium nanoparticles: selectivity patterns and accessibility constraints in the continuous‐flow three‐phase hydrogenation of acetylenic compounds

Vile, G.; Almora-Barrios, N.; Mitchell, S.; Lopez, N.; Perez-Ramirez, J.; Chem. Eur. J., 2014, 20, 5926-5937

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Fully automated sequence-specific synthesis of α-peptides using flow chemistry

Knudsen, K. R.; Ladlow, M.; Bandpey, Z.; Ley, S. V.; J. Flow Chem., 2014, 4(1), 18-21

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Functional Group Interconversion Reactions in Continuous Flow Reactors

Leslie, A. et al.; Curr. Org. Chem., 2021, 25, 19, 2217-2231

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Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation

Brice, H.; Clayden, J.; Hamilton, S. D.; Beilstein J. Org. Chem., 2010, 6(22)

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General methods for the synthesis and late-stage diversification of 2,4-substituted 7-azaindoles

Varnes, J. G.; McGuire, T.; Meadows, R. E.; Barlaam, B.; Clark, J.; Cook, C. R.; Davison, G.; Dishington, A.; De Savi, C.; Donald, C.; Grebe, T.; Hande, S.; Hawkins, J.; Hird, A. W.; Holmes, J.; Lister, A.; Lucas, S.; Moore, J.; Moore, E.; Patel, A.; Pike, K. G.; Roberts, B.; Stark, A.; Stead, D.; Thakur, K.; Turner, P.; Vasbinder, M.; Yang, B.; Tetrahedron Letters, 2016, 57, 4718-4722

Link to article

Gram scale de novo synthesis of 2,4-diacetamido-2,4,6-trideoxy-d-galactose

Schmolzer, C.; Nowikow, C.; Kahlig, H.; Schmid, W.; Carbohydrate Research, 2013, 367, 1-4

Link to article

Green and scalable procedure for extremely fast ligandless Suzuki-Miyaura cross-coupling reactions in aqueous IPA using solid-supported Pd in continuous flow

Mateos, C.; Rincon, J. A.; Martin-Hidalgo, B.; Villanueva, J.; Tetrahedron Letters, 2014, 55(27), 3701-3705

Link to article

Green chemistry articles of interest to the pharmaceutical industry

Andrews, I.; Dunn, P.; Hayler, J.; Himkley, B.; Hughes, D.; Kaptein, B.; Lorenz, K.; Methew, S.; Rammeloo, T.; Wang, L.; Wells, A.; White, T. D.; Org. Process Res. Dev., 2011, 15, 748-756

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Green Process Design for Reductive Hydroformylation of Renewable Olefin Cuts for Drop-In Diesel Fuels

Puschel, S. et al.; ChemSusChem, 2021, 14, 5226-5234

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Harnessing the versatility of continuous-flow processes: selective and efficient reactions

Mandity, I. M.; Otvos, S. B.; Szolosi, G.; Fulop, F.; Chem. Rec., 2016, 16, 1018-1033

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Hazards associated with laboratory scale hydrogenations

Chandra, T.; Zebrowski; J. P.; Journal of Chemical Health and Safety, 2016, 23(4), 16-25

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Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons

Belema, M.; Nguyen, V. N.; Romine, J. L.; St. Laurent, D. R.; Lopez, O. D.; Goodrich, J. T.; Nower, P. T.; O'Boyle, D. R.; Lemm, J. A.; Fridell, R. A.; Gao, M.; Fang, H.; Krause, R. G.; Wang, Y.; Oliver, A. J.; Good, A. C.; Knipe, J. O.; Meanwell, N. A.; Snyder, L. B.; J. Med. Chem., 2014, 57, 1995-2012

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Heterogeneous catalysis in continuous flow microreactors: a review of methods and applications

Tanimu, A.; Jaenicke, S.; Alhooshani, K.; Chem. Eng. J., 2017, 327, 792-821

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Heterogeneous Catalysis to Drive the Waste-to-Pharma Concept: From Furanics to Active Pharmaceutical Ingredients

Luque, R. et al.; Molecules, 2021, 26, 6738

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Heterogeneous catalytic hydrogenation reactions in continuous-flow reactors

Irfan, M.; Glasnov, N. T.; Kappe, O. C.; ChemSusChem, 2011, 12(3), 300-316

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Heterogeneous catalytic synthesis using microreactor technology

Frost, C. G.; Mutton, L.; Green Chem., 2010, 12, 1687-1703

Link to article

Heterogeneous enantioselective hydrogenation in a continuous-flow fixed-bed reactor system: Hydrogenation of activated ketones and their binary mixtures on Pt–alumina–cinchona alkaloid catalysts

Szollosi, G.; Makra, Zs.; Fekete, M.; Fulop, F.; Bartok, M.; Catal. Lett., 2012, 142(7), 889-894

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Heterogeneous hydrogenation reactions using a continuous flow high pressure device

Desai, B.; Kappe, C. O.; J. Comb. Chem., 2005, 7(5), 641-643

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Heterogeneous Palladium Catalysts in the Hydrogenation of the Carbon-carbon Double Bond

Grabovskii, S. A. et al.; Curr. Org. Chem., 2021, 25, 2, 315-329

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Heterogeneous versus homogeneous palladium catalysts for ligandless Mizoroki-Heck reactions: A comparison of batch/microwave and continuous‐flow processing

Glasnov, T. N.; Findenig, S.; Kappe, C. O.; Chem. Eur. J., 2009, 15, 1001-1010

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High-efficiency aminocarbonylation by introducing CO to a pressurized continuous flow reactor

Csajagi, Cs.; Borcsek, B.; Niesz, K.; Kovacs, I.; Szekelyhidi, Zs.; Bajko, Z.; Ugre, L.; Darvas, F.; Org. Lett., 2008, 10(8), 1589-1592

Link to article

High pressure in organic chemistry on the way to miniaturization

Benito-Lopez, F.; Egberink, E. J. M.; Reinhoudt, D. N.; Verboom, W.; Tetrahedron, 2008, 64(43), 10023-10040

Link to article

High-speed microwave assisted synthesis of SEA0400 – a selective inhibitor of the Na+/Ca2+ exchanger

de la Cruz, G. G.; Groschner, K.; Kappe, C. O.; Glasnov; T. N.; Tetrahedron Letters, 2012, 53, 3731-3734

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High-temperature Boc deprotection in flow and its application in multistep reaction sequences

Bogdan, R. A.; Charaschanya, M.; Dombrowski, A. W.; Wang, Y.; Djuric, S. W.; Org. Lett., 2016, 18(8), 1732-1735

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High-throughput Screening of Vanadium (IV) Oxide via Continuous Hydrothermal Flow Synthesis Reactor

Tran, M. K. et al.; Materials Chemistry, 2021, Working paper

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Highly active catalytic Ru/TiO2 nanomaterials for continuous production of γ-valerolactone

Xu, C.; Ouyang, W.; Munoz-Batista, M. J.; Fernandez-Garcia, M.; Luque, R.; ChemSusChem, 2018, 11(15), 2604-2611

Link to article

Highly efficient 1,4-addition of aldehydes to nitroolefins

Otvos, S. B.; Mandity, I. M.; Fulop, F.; ChemSusChem, 2012, 5, 266-269

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Highly efficient iron(0) nanoparticle-catalyzed hydrogenation in water in flow

Hudson, R.; Hamasaka, G.; Osako, T.; Yamada, Y. M. A.; Li, C-J.; Uozumi, Y.; Moores, A.; Green Chem., 2013, 15, 2141-2148

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Highly efficient reversible addition-fragmentation chain‐transfer polymerization in ethanol/water via flow chemistry

Ye, P.; Cao, P-F.; Su, Z.; Advincula, R.; Polymer Int., 2017, 66(9), 1252-1258

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Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives

Lengyel, L.; Nagy, T. Zs.; Sipos, G.; Jones, R.; Dorman, Gy.; Urge, L.; Darvas, F.; Tetrahedron Letters, 2012, 53(7), 738-743

Link to article

Highly selective continuous-flow synthesis of potentially bioactive deuterated chalcone derivatives

Hsieh, C.; Otvos, S. B.; Wu, Y.; Mandity, I. M.; Chang, F.; Fulop, F.; ChemPlusChem, 2015, 80(5), 859-864

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Highly selective deuteration of pharmaceutically relevant nitrogen-containing heterocycles: a flow chemistry approach

Otvos, S. B.; Mandity, I. M.; Fulop, F.; Mol. Divers., 2011, 15, 605-611

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Highly selective hydrogenation of R‑(+)-limonene to (+)-p- 1‑menthene in batch and continuous flow reactors

Rubulotta, G.; Luska, K. L.; Urbina-Blanco, C. A.; Eifert, T.; Palkovits, R.; Quadrelli, E. A.; Thieuleux, C.; Leitner, W.; ACS Sustainable Chem. Eng., 2017, 5, 3762-3767

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Hit optimization of 5-substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) inhibitors with in vivo activity in model of mood disorders

Furlotti, G.; Alisi, M. A.; Cazzolla, N.; Dragone, P.; Durando, L.; Magaro, G.; Mancini, F.; Mangano, G.; Ombrato, R.; Vitiello, M.; Armirotti, A.; Capurro, V.; Lanfranco, M.; Ottonello, G.; Summa, M.; Reggiani, A.; J. Med. Chem., 2015, 58(22), 8920-8937

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HKUST-1 silica aerogel composites: novel materials for the separation of saturated and unsaturated hydrocarbons by conventional liquid chromatography

Nuzhdin, A. L.; Shalygin, A. S.; Artiukha, E. A.; Chibiryaev, A. M.; Bukhtiyarova, G. A.; Martyanov, O. N.; RSC Adv., 2016, 6, 62501-62507

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Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

Manzoni, L.; Belvisi, L.; Bianchi, A.; Conti, A.; Drago, C.; de Matteo, M.; Ferrante, L.; Mastrangelo, E.; Perego, P.; Potenza, D.; Scolastico, C.; Servida, F.; Timpano, G.; Vasile, F., Rizzo, V.; Seneci, P.; Bioorg. Med. Chem., 2012, 20, 6687-6708

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How the mode of Candida antarctica lipase B immobilization affects the continuous-flow kinetic resolution of racemic amines at various temperatures

Boros, Z.; Falus, P.; Markus, M.; Weiser, D.; Olah, M.; Hornyanszky, G.; Nagy, J.; Poppe, L.; Journal of Molecular Catalysis B: Enzymatic, 2013, 85-86, 119-125

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Hydrogenation of Aqueous Acetic Acid over Ru-Sn/TiO2 Catalyst in a Flow-Type Reactor, Governed by Reverse Reaction

Zhao, Y. et al.; Catalysts, 2020, 10, 1270

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Hydrogenation of nitroarenes to anilines in a flow reactor using polystyrene supported rhodium in a catalyst-cartridge (Cart-Rh@PS)

Sharma, S.; Yamini; Das, P.; New J. Chem., 2018, 43, 1764-1769

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Hydrothermal formose reaction

Kopetzki, D.; Antonietti, M.; New J. Chem., 2011, 35, 1787-1794

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Identification and Characterization of Carprofen as a Multitarget Fatty Acid Amide Hydrolase/Cyclooxygenase Inhibitor

Favia, A. D.; Habrant, D.; Scarpelli, R.; Migliore, M.; Albani, C.; Bertozzi, S. M.; Dionisi, M.; Tarozzo, G.; Piomelli, D.; Cavalli, A.; De Vivo, M.; J. Med. Chem., 2012, 55, 8807-8826

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Identification and validation of small molecule modulators of the NusB-NusE interaction

Cossar, P. J. et al.; Bioorg. Med. Chem. Lett., 2017, 162-167

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Identification of a novel orally bioavailable phosphodiesterase 10A inhibitor with efficacy in animal models of schizophrenia

Bartolome-Nebreda, J. M.; de Diego, S. A. A.; Artola, M.; Delgado, F.; Delgado, O.; Martin-Martin, M. L.; Martinez-Viturro, C. M.; Pena, M. A.; Tong, H. M.; Van Gool, M.; Alonso, J. M.; Fontana, A.; Macdonald, G. J.; Megens, A.; Langlois, X.; Somers, M.; Vanhoof, G.; Conde-Ceide, S.; J. Med. Chem., 2015, 58(2), 978-993

Link to article

Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington’s Disease

Ladduwahetty, T. et al.; J. Med. Chem., 2022, 65, 14, 9819-9845

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Immobilized iron oxide nanoparticles as stable and reusable catalysts for hydrazine‐mediated nitro reductions in continuous flow

Moghaddam, M. M.; Pieber, B.; Glasnov, T.; Kappe, C. O.; ChemSusChem, 2014, 7(11), 3122-3131

Link to article

Immobilized phosphine–phosphite rhodium complexes: highly active and enantioselective catalysts for asymmetric hydrogenation under continuous flow conditions

Madarasz, J.; Nanasi, B.; Kovacs, J.; Balogh, S.; Farkas, G.; Bakos, J.; Monatsh. Chem., 2018, 149(1), 19-25

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Immobilized transition metals as catalysts for cross-couplings in continuous flow — A critical assessment of the reaction mechanism and metal leaching

Cantillo, D.; Kappe, C. O.; ChemCatChem, 2014, 6(12), 3286-3305

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Important industrial procedures revisited in flow: very efficient oxidation and N-alkylation reactions with high atom-economy

Sipos, G.; Gyollai, V.; Dorman, G.; Kocsis, L.; Jones, R. V.; Darvas, F.; Journal of Flow Chemistry, 2013, 3(2), 51-58

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Improved and scalable synthesis of building blocks for the modular synthesis of teraryl-based alpha-helix mimetics

Trobe, M.; Breinbauer, R.; Monatsh. Chem., 2016, 147(3), 509-521

Link to article

Improved continuous flow processing: benzimidazole ring formation via catalytic hydrogenation of an aromatic nitro compound

Chen, J.; Przyuski, K.; Roemmele, R.; Bakale, R. P.; Org. Process Res. Dev., 2014, 18(11), 1427-1433

Link to article

Improving productivity of multiphase flow aerobic oxidation using a tube-in-tube membrane contactor

Burkholder, M.; Gilliland, S. E.; Luxon, A.; Tang, C.; Gupton, B. F.; Catalysts, 2019, 9(1), 95

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In situ sulfidation of Pd/C: A Straightforward method for chemoselective conjugate reduction by continuous hydrogenation

Moore, J. C.; Howie, R. A.; Bourne, S. L.; Jenkins, G. N.; Licence, P.; Poliakoff, M.; George, M. W.; ACS Sustainable Chem. Eng., 2019, 7(19), 16814-16819

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In vitro reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors

Tan, G-Y.; Zhu, F.; Deng, Z.; Liu, T.; Synthetic and Systems Biotechnology, 2016, 1, 25-33

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Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites

Shamovsky, I.; de Graaf, C.; Alderin, L.; Bengtsson, M.; Bladh, H.; Börjesson, L.; Connolly, S.; Dyke, H. J.; van den Heuvel, M.; Johansson, H.; Josefsson, B.; Kristoffersson, A.; Linnanen, T.; Lisius, A.; Mannikko, R.; Norden, B.; Price, S.; Ripa, L.; Rognan, D.; Rosendahl, A.; Skrinjar, M.; Urbahns, K.; J. Med. Chem., 2009, 52, 7706-7723

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Innovative benign-by-design flow chemistry protocols: from bio(nano)materials synthesis to biomass/waste valorisation

Wang, B.; Balu, A. M.; Xuan, J.; Gonzalez-Arellano, C.; Bai, Z.; Luque, R.; Chemistry Today, 2016, 34(6), 58-63

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Insights into the activity, selectivity and stability of heterogeneous catalysts in the continuous flow hydroconversion of furfural

Garcia-Olmo, A. J.; Yepez, A.; Balu, A. M.; Romero, A. A.; Li, Y.; Luque, R.; Catal. Sci. Technol., 2016, 6(13), 4705-4711

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Insights into the selective hydrogenation of levulinic acid to γ-valerolactone using supported mono- and bimetallic catalysts

Al-Naji, M.; Yepez, A.; Balu, A. M.; Romero, A. A.; Chen, Z.; Wilde, N.; Li, H.; Shih, K.; Glaser, R.; Luque, R.; Journal of Molecular Catalysis A: Chemical, 2016, 417, 145-152

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Integrated Suzuki Cross-Coupling/Reduction Cascade Reaction of meta-/para-Chloroacetophenones and Arylboronic Acids under Batch and Continuous Flow Conditions

Li, Y. et al.; Chem. Asian J., 2021, 16(16), 2338-2345

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Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Ingham, R. J.; Battilocchio, C.; Hawkins, J. M.; Ley, S. V.; Beilstein J. Org. Chem., 2014, 10, 641-652

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Intensified Continuous Flow Michaelis-Arbuzov Rearrangement toward Alkyl Phosphonates

Toupy, T. et al.; Org. Process Res. Dev., 2022, 26(2), 467-478

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Interesting applications on a novel high pressure high temperature microfluidic-based flow reactor

Niesz, K.; Csajagi, Cs.; Borcsek, B.; Jones, R. V.; Darvas, F.; Nanotechnology, 2007, 4, 426-429

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Intramolecular aglycon delivery enables the synthesis of 6-deoxy-β-d-manno-heptosides as fragments of Burkholderia pseudomallei and Burkholderia mallei capsular polysaccharide

Kenfack, M. T.; Bleriot, Y.; Gauthier, C.; J. Org. Chem., 2014, 79(10), 4615-4634

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Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism

Baldwin, I. R. et al.; J. Med. Chem., 2022, 65(1), 633-664

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Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs)

Linciano, P. et al.; Bioorg. Chem., 2021, 106, 104462

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Investigation, optimization and synthesis of sulfamoyloxy-linked aminoacyl-AMP analogues

Redwan, I. N.; Ljungdahl, T.; Grotli, M.; Tetrahedron, 2012, 68(5), 1507-1514

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Ion exchange resins: Catalyst recovery and recycle

Barbaro, P.; Liguori, F.; Chem. Rev., 2009, 109(2), 515-529

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Iridium(I)-catalyzed ortho-directed hydrogen isotope exchange in continuous-flow reactors

Habraken, E.; Haspeslagh, P.; Vliegen, M.; Noel, T.; J. Flow Chem., 2015, 5(1), 2-5

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Iridium(I)-NHC-phosphine complex-catalyzed hydrogen generation and storage in aqueous formate/bicarbonate solutions using a flow reactor – Effective response to changes in hydrogen demand

Horvath, H.; Papp, G.; Kovacs, H.; Katho, A.; Joo, F.; Int. J. Hydrogen Energy, 2019, 44(53), 28527-28532

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Isolation and characterization of anti-adenoviral secondary metabolites from marine actinobacteria

Strand, M.; Carlsson, M.; Uvell, H.; Islam, K.; Edlund, K.; Cullman, I.; Altermark, B.; Mei, Y-F.; Elofsson, M.; Willassen, N. P.; Wadell, G.; Almqvist, F. Mar. Drugs, 2014, 12(2), 799-821

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Landscape and opportunities for active pharmaceutical ingredient manufacturing in developing African economies

Panayides, J. L.; Riley, D. L.; Chikwamba, R.; Strydom, I.; React. Chem. Eng., 2019, 4, 457-489

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Latest highlights in liquid-phase reactions for organic synthesis in microreactors

Protasova, L. N.; Bulut, M.; Ormerod, D.; Buekenhoudt, A.; Berton, J.; Stevens, C. V.; Org. Process Res. Dev., 2013, 17(5), 760-791

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Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound

Tarleton, M.; Gilbert, J; Robertson, J. M.; McCluskey, A.; Sakoff, A. J; MedChemComm, 2011, 2, 31-37

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Library synthesis of cardiomyogenesis inducing compounds using an efficient two-step-one-flow process

Schon, M.; Dreier, D.; Schnurch, M.; Mihovilovic, M. D.; Monatsh. Chem., 2016, 147(3), 523-532

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Life cycle analysis within pharmaceutical process optimization and intensification: case study of active pharmaceutical ingredient production

Ott, D.; Kralisch, D.; Dencic, I.; Hessel, V.; Laribi, Y.; Perrichon, P. D.; Berguerand, C.; Kiwi-Minsker, L.; Loeb, P.; ChemSusChem, 2014, 7, 3521-3533

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Ligand ordering determines the catalytic response of hybrid palladium nanoparticles in hydrogenation

Albani, D.; Vile, G.; Mitchell, S.; Witte, P. T.; Almora-Barrios, N.; Verel, R.; Lopez, N.; Perez-Ramirez, J.; Catal. Sci. Technol., 2016, 6(6), 1621-1631

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Lipase-catalyzed kinetic resolution of 2-methylene-substituted cycloalkanols in batch and continuous-flow modes

Tomin, A.; Hornyanszky, G.; Kupai, K.; Dorko, Zs.; Urge, L.; Darvas, F.; Poppe, L.; Process Biochemistry, 2010, 45(6), 859-865

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Lipase-catalyzed monostearin synthesis under continuous flow conditions

Junior, I. I.; Flores, M. C.; Sutili, F. K.; Leite, S. G. F.; Miranda, L. S. de M.; Leal, I. C. R.; de Souza, R. O. M. A.; Org. Process Res. Dev., 2012, 16(5), 1098-1101

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Liquid phase oxidation chemistry in continuous-flow microreactors

Gemoets, H. P. L.; Su, Y.; Shang, M.; Hessel V.; Luque, R.; Noel, T.; Chem. Soc. Rev., 2016, 45, 83-117

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Living with our machines: Towards a more sustainable future

Chen, Y. et al.; Curr. Op. in Green and Sus. Chem., 2020, 25, 100353

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Measurement of supramolecular effective molarities for intramolecular H-bonds in zinc porphyrin-imidazole complexes

Jinks, M. A.; Sun, H.; Hunter, C. A.; Org. Biomol. Chem., 2014, 12, 1440-1447

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Mechanistic insights into copper(I)‐catalyzed azide‐alkyne cycloadditions using continuous flow conditions

Fuchs, M.; Goessler, W.; Pilger, C.; Kappe, C. O.; Adv. Synth. Catal., 2010, 352, 323-328

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Mechanochemical Synthesis of Nickel-Modified Metal-Organic Frameworks for Reduction Reactions

Gomez-Lopez, P. et al.; Catalysts, 2021, 11, 526

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Merging single-atom-dispersed silver and carbon nitride to a joint electronic system via copolymerization with silver tricyanomethanide

Chen, Z.; Pronkin, S.; Fellinger, T. P.; Kailasam, K.; Vile, G.; Albani, D.; Krumeich, F.; Leary, R.; Barnard, J.; Thomas, J. M.; Perez-Ramirez, J.; Antonietti, M.; Dontsova, D.; ACS Nano, 2016, 10(3), 3166-3175

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Mesoscale flow chemistry: A plug-flow approach to reaction optimisation

Wheeler, R. C.; Benali, O.; Deal, M.; Farrant, E.; MacDonald, S. J. F.; Warrington, B. H.; Org. Process Res. Dev., 2007, 11, 704-710

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Metal-catalyzed amidation

Roy, S.; Roy, S.; Gribble, G. W.; Tetrahedron, 2012, 68, 9867-9923

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Metathesis reactions on solid-phase: Towards new synthesis challenges

Franzen, R. G.; Top Catal., 2016, 59, 1143-1150

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Methods for the synthesis of indole-3-carboxylic acid esters

Litvinova, V. A.; Tikhomirov, A. S.; Chemistry of Heterocyclic Compounds, 2018, 54, 923-925

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Methylation using dimethylcarbonate catalysed by ionic liquids under continuous flow conditions

Glasnov, T. N.; Holbrey, J. D.; Kappe, C. O.; Seddon, K. R.; Yan, T.; Green Chem., 2012, 14, 3071-3076

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Micro reactors, flow reactors and continuous flow synthesis

Watts, P.; Wiles, C.; Journal of Chemical Research, 2012, 36, 181-193

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Microfluidics in commercial applications; an industry perspective

Haber, C.; Lab Chip, 2006, 6, 1118-1121

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Microreactors for peptide synthesis: looking through the eyes of twenty first century !!!

Ramesh, S.; Cherkupally, P.; de la Torre, B. G.; Govender, T.; Kruger, H. G.; Albericio, F.; Amino Acids, 2014, 46, 2091-2104

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Microwave-assisted and continuous flow multistep synthesis of 4-(pyrazol-1-yl)carboxanilides

Obermayer, D.; Glasnov, T. N.; Kappe, C. O.; J. Org. Chem., 2011, 76(16), 6657-6669

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Microwave-assisted grafting to MCM-41 silica and its application as catalyst in flow chemistry

Oliverio, M.; Procopio, A.; Glasnov, T. N.; Goessler, W.; Kappe, C. O.; Aust. J. Chem., 2011, 64, 1522-1529

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Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters

Desai, B.; Dallinger, D.; Kappe, C. O.; Tetrahedron, 2006, 62, 4651-4664

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Microwave-assisted synthesis of medium-sized heterocycles

Sharma, A.; Appukkuttan, P.; Van der Eycken, E.; Chem. Commun., 2012, 48, 1623-1637

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Microwave chemistry enabling the synthesis of biologically relevant amines

Spencer, J.; Future Med. Chem., 2010, 2(2), 161-168

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Microwave heating and conventionally-heated continuous-flow processing as tools for performing cleaner palladium-catalyzed decarboxylative couplings using oxygen as the oxidant – a proof of principle study

Rudzinski, D. M.; Leadbeater, N. E.; Green Processing and Synthesis, 2013, 2(4), 323-328

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Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library

Spencer, J.; Patel, H.; Amin, J.; Callear, S. K.; Coles, S. J.; Deadman, J. J.; Furman, C.; Mansouri, R.; Chavatte, P.; Millet, R.; Tetrahedron Letters, 2012, 53, 1656-1659

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Mild and selective hydrogenation of nitro compounds using palladium nanoparticles supported on amino‐functionalized mesocellular foam

Verho, O.; Gustafson, K. P. J.; Nagendiran, A.; Tai, C.; Backvall, J.; ChemCatChem, 2014, 6(11), 3153-3159

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Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507

Scott, D. A.; Dakin, L. A.; Daly, K.; Del Valle, D. J.; Diebold, R. B.; Drew, L.; Ezhuthachan, J.; Gero, T. W.; Ogoe, C. A.; Omer, C. A.; Redmond, S. P.; Repik, G.; Thakur, K.; Ye, Q.; Zheng, X.; Bioorg. Med. Chem. Lett., 2013, 23, 4591-4596

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Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB)

Jurutka, P. W. et al.; Int. J. Mol. Sci., 2021, 22, 12371

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Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN)

Heck, M. C. et al.; J. Med. Chem., 2016, 59, 8924-8940

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Modeling, synthesis and biological evaluation of potential retinoid X receptor‐selective agonists: Novel halogenated analogues of 4‐[1‐(3,5,5,8,8‐pentamethyl‐5,6,7,8‐tetrahydro‐2‐naphthyl)ethynyl]benzoic acid (Bexarotene)

Furmick, J. K.; Kaneko, I.; Walsh, A. N.; Yang, J.; Bhogal, J. S.; Gray, G. M.; Baso, J. C.; Browder, D. O., Prentice, J. L. S.; Montano, L. A.; Huynh, C. C.; Marcus, L. M.; Tsosie, D. G.; Kwon, J. S.; Quezada, A.; Reyes, N. M.; Lemming, B.; Saini, P.; van der Vaart, A.; Groy, T. L.; Marshall, P. A.; Jurutka, P. W.; Wagner, C. E.; ChemMedChem, 2012, 7, 1551-1566

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Molecularly imprinted hydrogels as functional active packaging materials

Benito-Pena, E.; Gonzalez-Vallejo, V.; Rico-Yuste, A.; Barbosa-Pereira, L.; Cruz, J. M.; Bilbao, A.; Alvarez-Lorenzo, C.; Moreno-Bondi, M. C.; Food Chemistry, 2016, 190, 487-494

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Molecularly imprinted polymers for cleanup and selective extraction of curcuminoids in medicinal herbal extracts

Wulandari, M.; Urraca, J. L.; Descalzo, A. B.; Amran, M. B.; Moreno-Bondi, M. C.; Analytical and Bioanalytical Chemistry, 2015, 407(3), 803-812

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Monitoring glycan-protein interactions by NMR spectroscopic analysis: A simple chemical tag that mimics natural CH–π interactions

Calle, L. P.; Echeverria, B.; Franconetti, A.; Serna, S.; Fernandez-Alonso, M. C.; Diercks, T.; Canada, F. J.; Arda, A.; Reichardt, N. C.; Jimenez-Barbero, J.; Chem. Eur. J., 2015, 21(32), 11408-11416

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Multi-step continuous-flow synthesis

Britton, J. et al.; Chem. Soc. Rev., 2017, 46, 1250-1271

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Multi-step solvent-free 3 m2 footprint pilot miniplant for the synthesis of annual half ton rufinamide precursor

Gelonch, M. E.; de Leon Izeppi, G. A.; Kirschneck, D.; Hessel, V.; ACS Sustainable Chem. Eng., 2019, 7(20), 17237-17251

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Multigram-scale flow synthesis of the chiral key intermediate of (−)-paroxetine enabled by solvent-free heterogeneous organocatalysis

Otvos, S. B.; Pericas, M. A.; Kappe, C. O.; Chem. Sci., 2019, 10, 11141-11146

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Multigram Synthesis of Tetrasubstituted Dihydrobenzofuran GSK973 Enabled by High-Throughput Experimentation and a Claisen Rearrangement in Flow

Gray, M. et al.; Org. Process Res. Dev., 2022, 26(2), 365-379

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Multistep continuous‐flow synthesis in medicinal chemistry: Discovery and preliminary structure-activity relationships of CCR8 ligands

Petersen, T. P.; Mirsharghi, S.; Rummel, P. C.; Thiele, S.; Rosenkilde, M. M.; Ritzen, A.; Ulven, T.; Chem. Eur. J., 2013, 19(28), 9343-9350

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Multistep continuous-flow synthesis of condensed benzothiazoles

Lovei, K.; Greiner, I.; Eles, J.; Szigetvari, A.; Dekany, M.; Levai, S.; Novak, Z.; Turos, I. Gy.; J. Flow Chem., 2015, 5(2), 74-81

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Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties as novel synthetic polyphenols directed against HIV-1

Flores, A.; Camarasa, M. J.; Perez-Perez, M. J.; San-Felix, A.; Balzarini, J.; Quesada, E.; Org. Biomol. Chem., 2014, 12, 5278-5294

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My twenty years in microwave chemistry: from kitchen ovens to microwaves that aren’t microwaves

Kappe, C. O.; Chem. Rec., 2019, 19(1), 15-39

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N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist

Boldron, C.; Besse, A.; Bordes, M.; Tissandie, S.; Yvon, X.; Gau, B.; Badorc, A.; Rousseaux, T.; Barre, G.; Meneyrol, J.; Zech, G.; Nazare, M.; Fossey, V.; Pflieger, A.; Bonnet-Lignon, S.; Millet, L.; Briot, C.; Dol, F.; Herault, J.; Savi, P.; Lassalle, G.; Delesque, N.; Herbert, J.; Bono, F.; J. Med. Chem., 2014, 57(17), 7293-7316

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Nafion‐H‐catalyzed high‐temperature/high‐pressure synthesis of a triarylmethane in continuous‐flow mode

Hayden, S.; Glasnov, T.; Kappe, C. O.; Chem. Eng. Technol., 2015, 38(10), 1743-1748

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Nanocatalysis in continuous flow: supported iron oxide nanoparticles for the heterogeneous aerobic oxidation of benzyl alcohol

Obermayer, D.; Balu, A. M.; Romero, A. A.; Goessler, W.; Luque, R.; Kappe, C. O.; Green Chem., 2013, 15, 1530-1537

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Nanocatalysis in flow

Ricciardi, R.; Huskens, J.; Verboom, W.; ChemSusChem, 2015, 8(16), 2586-2605

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Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow

Nagendiran, A.; Sorensen, H.; Johansson, M. J.; Tai, C-W.; Backvall, J-E.; Green Chem., 2016, 18(9), 2632-2637

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Nanoparticle synthesis completed with in situ catalyst preparation performed on a high-pressure high-temperature continuous flow reactor

Niesz, K.; Hornyak, I.; Borcsek, B.; Darvas, F.; Microfluidics and Nanofluidics, 2008, 5(3), 411-416

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Nanoscale Pd supported on 3D porous carbon for enhanced selective oxidation of benzyl alcohol

Niu, S. et al.; RSC Adv., 2017, 7, 25885-25890

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Nanotechnology tools in pharmaceutical R&D

Kumar, C. S. S. R.; Materials Today, 2010, 12, 24-30

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Natural‐product‐like spiroketals and fused bicyclic acetals as potential therapeutic agents for B‐cell chronic lymphocytic leukaemia

Milroy, L-G.; Zinzalla, G.; Loiseau, F.; Qian, Z.; Prencipe, G.; Pepper, C.; Fegan, C.; Ley, S. V.; ChemMedChem, 2008, 3, 1922-1935

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Natural product synthesis on the fly – multistep continuous reaction shows the power of automated flow synthesis

Ritter, S. K.; Chemical & Engineering News, 2006, 84(10), 17

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New copper-containing catalysts based on modified amorphous silica and their use in flow azide—alkyne cycloaddition

Burilov, V. A.; Nurmukhametova, A. N.; Belov, R. N.; Mironova, D. A.; Vorob'ev, V. V.; Osin, Yu. N.; Antipin, I. S.; Russian Chemical Bulletin Int. Ed., 2018, 67, 461-468

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New data in the enantioselective hydrogenation of ethyl pyruvate on Pt-cinchona chiral catalyst using continuous-flow fixed-bed reactor system: The origin of rate enhancement

Szollosi, Gy.; Cserenyi, Sz.; Balazsik, K.; Fulop, F.; Bartok, M.; Journal of Molecular Catalysis A: Chemical, 2009, 305, 155-160

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New data on the Orito reaction: Effect of substrate structure on nonlinear phenomenon

Balazsik, K.; Cserenyi, S.; Szollosi, G.; Fulop, F.; Bartok, M.; Catal. Lett., 2008, 125, 401-407

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New data to the origin of rate enhancement on the Pt-cinchona catalyzed enantioselective hydrogenation of activated ketones

Szollosi, G.; Cserenyi, S.; Fulop, F.; Bartok, M.; Journal of Catalysis, 2008, 260(2), 245-253

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New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics

Pilkington-Miksa, M.; Araldi, E. M.; Arosio, D.; Belvisi, L.; Civera, M.; Manzoni, L.; Org. Biomol. Chem., 2016, 14(12), 3221-3233.

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Nickel-catalyzed reductive [2+2] cycloaddition of alkynes

Canellas, S.; Montgomery, J.; Pericas, M. A.; J. Am. Chem. Soc., 2018, 140(50), 17349-17355

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Nitro lignin-derived nitrogen-doped carbon as an efficient and sustainable electrocatalyst for oxygen reduction

Graglia, M.; Pampel, J.; Hantke, T.; Fellinger, T. P.; Esposito D.; ACS Nano, 2016, 10(4), 4364-4371

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Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis

Jarrad, A. M.; Debnath, A.; Miyamoto, Y.; Hansford, K. A.; Pelington, R.; Butler, M. S.; Bains, T.; Karoli, T.; Blaskovich, M. A. T.; Eckmann, L.; Cooper, M. A.; Eur. J. Med. Chem., 2016, 120, 353-362

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Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

Gauthier, C.; Chassagne, P.; Theillet, F. X.; Guerreiro, C.; Thouron, F.; Nato, F.; Delepierre, M.; Sansonetti, P. J.; Phalipon, A.; Mulard, L. A.; Org. Biomol. Chem., 2014, 12, 4218-4232

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Novel biorefinery concept via Achmatowicz rearrangement, synthesis of pentane‐1,2,5‐triol from furfuryl alcohol

Simeonov, S. P.; Ravutsov, M. A.; Mihovilovic, M. D.; ChemSusChem, 2019, 12(12), 2748-2754

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Novel derivatives of usnic acid effectively inhibiting reproduction of influenza A virus

Shtro, A. A.; Zarubaev, V. V.; Luzina, O. A.; Sokolov, D. N.; Kiselev, O. I.; Salakhutdinov, N. F.; Bioorg. Med. Chem., 2014, 22(24), 6826-6836

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Novel evidence on the role of the nucleophilic intermediate complex in the Orito-reaction: Unexpected inversion in the enantioselective hydrogenation of 2,2,2-trifluoroacetophenone on Pt-cinchona chiral catalyst using continuous-flow fixed-bed reactor

Szollosi, G.; Cserenyi, S.; Bartok, M.; Catal. Lett., 2010, 134, 264-269

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Novel phosphine-phosphites and their use in asymmetric hydrogenation

Farkas, G.; Balogh, S.; Szollosy, A.; Urge, L.; Darvas, F.; Bakos, J.; Tetrahedron: Asymmetry, 2011, 22(24), 2104-2109

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Novel process windows for enabling, accelerating and uplifting flow chemistry

Hessel, V.; Kralisch, D.; Kockmann, N.; Noel, T.; Wang, Q.; ChemSusChem, 2013, 6(5), 746-789

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Novel spirotetracyclic zwitterionic dual H1/5-HT2A receptor antagonists for the treatment of sleep disorders

Gianotti, M.; Botta, M.; Brough, S.; Carletti, R.; Castiglioni, E.; Corti, C.; Dal-Cin, M.; Fratte, S. D.; Korajec, D.; Lovric, M.; Merlo, G.; Mesic, M.; Pavone, F.; Piccoli, L.; Rast, S.; Roscic, M.; Sava, A.; Smehil, M.; Stasi, L.; Togninelli, A.; Wigglesworth, M. J.; J. Med. Chem., 2010, 53, 7778-7795

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Nucleophilic aromatic substitution of heterocycles using a high-temperature and high-pressure flow reactor

Charaschanya, M.; Bogdan, A. R.; Wang, Y.; Djuric, S. W.; Tetrahedron Letters, 2016, 57(9), 1035-1039

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Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1

Manka, J. T.; Rodriguez, A. L.; Morrison, R. D.; Venable, D. F.; Cho, H. P.; Blobaum, A. L.; Daniels, J. S.; Niswender, C. M.; Conn, P. J.; Lindsley, C. W.; Emmitte, K. A.; Bioorg. Med. Chem. Lett., 2013, 23(18), 5091-5096

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On the regioselectivity of the Gould–Jacobs reaction: Gas-phase versus solution-phase thermolysis

Wernik, M.; Hartmann, P. E.; Sipos, G.; Darvas, F.; Boese, A. D.; Dallinger, D.; Kappe, C. O.; Eur. J. Org. Chem., 2020, 45, 7051-7061 Link to article

One-pot reductive amination of aldehydes with nitroarenes over an Au/Al2O3 catalyst in a continuous flow reactor

Artiukha, E. A.; Nuzhdin, A. L.; Bukhtiyarova, G. A.; Zaytsev, S. Yu.; Plyusnin, P. E.; Shubinbc, Yu. V.; Bukhtiyarov, V. I.; Cat. Sci. Technol., 2015, 5(10), 4741-4745

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One-pot synthesis of secondary amines from nitroarenes and aldehydes on supported copper catalysts in a flow reactor: The effect of the support

Artyukha, E. A.; Nuzhdin, A. L.; Bukhtiyarova, G. A.; Derevyannikova, E. A.; Gerasimov, E. Yu.; Gladkii, A. Yu.; Bukhtiyarov, V. I.; Kinetics and Catalysis, 2018, 59(5), 593-600

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Online monitoring and analysis for autonomous continuous flow self-optimizing reactor systems

Fabry, D. C.; Sugiono, E.; Rueping M.; React. Chem. Eng., 2016, 1, 129-133

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Optically pure, structural, and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach

Liu, M.; Mountford, S. J.; Richardson, R. R.; Groenen, M.; Holliday, N. D.; Thompson, P. E.; J. Med. Chem., 2016, 59(13), 6059-6069

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Optimisation of conditions for O‐benzyl and N‐benzyloxycarbonyl protecting group removal using an automated flow hydrogenator

Knudsen, K. R.; Holden, J.; Ley, S. V.; Ladlow, M.; Adv. Synth. Catal., 2007, 349, 535-538

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Optimization of novel indazoles as highly potent and selective inhibitors of phosphoinositide 3-kinase δ for the treatment of respiratory disease

Down, K.; Amour, A.; Baldwin, I. R.; Cooper, A. W. J.; Deakin, A. M.; Felton, L. M.; Guntrip, S. B.; Hardy, C.; Harrison, Z. A.; Jones, K. L.; Jones, P.; Keeling, S. E.; Le, J.; Livia, S.; Lucas, F.; Lunniss, C. J.; Parr, N. J.; Robinson, E.; Rowland, P.; Smith, S.; Thomas, D. A.; Vitulli, G.; Washio, Y.; Hamblin, J. N.; J. Med. Chem., 2015, 58(18), 7381-7399

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Optimized Conditions for Passerini-Smiles Reactions and Applications to Benzoxazinone Syntheses

Martinand-Lurin, E. et al.; Molecules, 2016, 21, 1257

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Organic synthesis: March of the machines

Ley, S. V.; Fitzpatrick, D. E.; Ingham, R. J.; Myers, R. M.; Angewandte Chemie Int. Ed., 2015, 54(11), 3449-3464

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Origin of problems related to Staudinger reduction in carbopeptoid syntheses

Csordas, B.; Nagy, A.; Harmat, V.; Zsoldos-Mady, V.; Leveles, I.; Pinter, I.; Farkas, V.; Perczel, A.; Amino Acids, 2016, 48(11), 2619-2633

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Origin of the rate enhancement and enantiodifferentiation in the heterogeneous enantioselective hydrogenation of 2,2,2-trifluoroacetophenone over Pt/alumina studied in continuous-flow fixed-bed reactor system

Szollosi, Gy.; Cserenyi, Sz.; Bucsi, I.; Bartok, T.; Fulop, F.; Bartok, M.; Applied Catalysis A: General, 2010, 382, 263-271

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Out-smarting smart drug modafinil through flow chemistry

Silva-Brenes, D. V. et al.; Green Chemistry, 2022, 24, 2094-2103

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Oxazolomycins: Natural product lead structures for novel antibacterials by click fragment conjugation

Bagwell, C. L.; Moloney, M. G.; Yaqoob, M.; Bioorg. Med. Chem. Lett., 2010, 20(7), 2090-2094

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p-Nitrophenol flow hydrogenation with nano-Cu2O grafted on polymeric resin

Paun, C.; Gizinski, D.; Zienkiewicz-Machnik, M.; Banas, D.; Kubala-Kukus, A.; Sa, J.; Catalysis Communications, 2017, 92, 61-64

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Palladium on carbon-catalyzed Suzuki-Miyaura coupling reaction using an efficient and continuous flow system

Hattori, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Catalysts, 2015, 5, 18-25

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Papain‐specific activating esters in aqueous dipeptide synthesis

de Beer, R. J. A. C.; Zarzycka, B.; Mariman, M.; Amatdjais-Groenen, H. I. V.; Mulders, M. J.; Quaedflieg, P. J. L. M.; van Delft, F. L.; Nabuurs, S. B.; Rutjes, F. P. J. T.; ChemBioChem, 2012, 13(9), 1319-1326

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Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor

Miller, D. C. et al.; J. Med. Chem., 2022, 65(9), 6513-6540

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Parallel synthesis of 1,2,4-triazole derivatives using microwave and continuous-flow techniques

Szommer T.; Lukacs A.; Kovacs J.; Szabo, M. J.; Hoffmann M. G.; Schmitt M. H.; Gerencser J.; Mol. Divers., 2012, 16(1), 81-90

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Particle-based immobilized enzymatic reactors in microfluidic chips

Kecskemeti, A. et al.; Talanta, 2017, 180, 211-228

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Pd nanoparticles on carbon layer wrapped 3D TiO2 as efficient catalyst for selective oxidation of benzyl alcohol

Wu, Y. et al.; Chem. Phys. Lett., 2018, 712, 149-154

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Pd-P nanoalloys supported on porous carbon frame as efficient catalyst for benzyl alcohol oxidation

Guo, W.; Niu, S.; Shi, W.; Zhang, B.; Yu, W.; Xie, Y.; Ji, X.; Wu, Y.; Su, D.; Shao, L.; Catal. Sci. Technol., 2018, 8, 2333-2339

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Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor

Salamoun, J. M.; McQueeney, K. E.; Patil, K.; Geib, S. J.; Sharlow, E. R.; Lazo, J. S.; Wipf, P.; Org. Biomol. Chem., 2016, 14(27), 6398-6402

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Polysaccharides from Burkholderia species as targets for vaccine development, immunomodulation and chemical synthesis

Cloutier, M.; Muru, K.; Ravicoularamin, G.; Gauthier, C.; Nat. Prod. Rep., 2018, 35, 1251-1293

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Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure–activity relationship (SAR) studies

Nuzzi, A.; Fiasella, A.; Ortega, J. A.; Pagliuca, C.; Ponzano, S.; Pizzirani, D.; Bertozzi, S. M.; Ottonello, G.; Tarozzo, G.; Reggiani, A.; Bandiera, T.; Bertozzi, F.; Piomelli, D.; Eur. J. Med. Chem., 2016, 111, 138-159

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Potentiating N-Hydroxyphthalimide Catalyzed Aerobic Aldehyde Oxidations in Continuous Flow

Kappe, C. O. et al.; Adv. Synth. Catal., 2022, Accepted manuscript

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Practical synthesis of (S)-pyrrolidin-2-yl-1H-tetrazole, incorporating efficient protecting group removal by flow-reactor hydrogenolysis

Franckevicius, V.; Knudsen, K. R.; Ladlow, M.; Longbottom, D. A.; Ley, S. V.; Synlett, 2006, 6, 889-892

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Preclinical characterization of the FAAH inhibitor JNJ-42165279

Keith, J. M.; Jones, W. M.; Tichenor, M.; Liu, J.; Seierstad, M.; Palmer, J. A.; Webb, M.; Karbarz, M.; Scott, B. P.; Wilson, S. J.; Luo, L.; Wennerholm, M. L.; Chang, L.; Rizzolio, M.; Rynberg, R.; Chaplan, S. R.; Breitenbucher, J. G.; ACS Med. Chem. Lett., 2015, 6(12), 1204-1208

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Precursor Nuclearity and Ligand Effects in Atomically-Dispersed Heterogeneous Iron Catalysts for Alkyne Semi-Hydrogenation

Faust Akl, D. et al.; ChemCatChem, 2021, 13(14), 3247-3256

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Prediction of Optimal Conditions of Hydrogenation Reaction Using the Likelihood Ranking Approach

Afonina, V. A. et al.; Int. J. Mol. Sci., 2022, 23, 248

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Preparation of HKUST-1@silica aerogel composite for continuous flow catalysis

Shalygin, A. S.; Nuzhdin, A. L.; Bukhtiyarova, G. A.; Martyanov, O. N.; J. Sol-Gel Sci. Technol., 2017, 84(3), 446-452

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Preparation of vinyl ethers using a Wittig approach, and their subsequent hydrogenation employing continuous-flow processing

Balti, M.; Efrit, M. L.; Leadbeater, N. E.; Tetrahedron Lett., 2016, 57, 1804-1806

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Present and future of cyclopropanations in fragrance chemistry

Schroder, F.; Chem. Biodivers., 2014, 11(11), 1734-1751

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Process development of a potent glucosylceramide synthase inhibitor

Cooper, C. G. F.; Lee, E. R.; Silva, R. A.; Bourque, A. J.; Clark, S.; Katti, S.; Nivorozkhin, V.; Org. Process Res. Dev., 2012, 16(5), 1090-1097

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Process intensification for the continuous flow hydrogenation of ethyl nicotinate

Ouchi, T.; Battilocchio, C.; Hawkins, J. M.; Ley, S. V.; Org. Process Res. Dev., 2014, 18(11), 1560-1566

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Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors

George, D. M.; Huntley, R. J.; Cusack, K.; Duignan, D. B.; Hoemann, M.; Loud, J.; Mario, R.; Melim, T.; Mullen, K.; Somal, G.; Wang, L.; Edmunds, J. J.; PlosOne, 2018, online article

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Pt-cinchonidine catalyzed asymmetric catalytic cascade reaction of 2-nitrophenylpyruvates in flow system

Kovacs, L.; Szollosi, Gy.; Fulop, F.; J. Flow Chem., 2015, 5(4), 210-215

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Pyrido[2,3-d]pyrimidin-5-ones: A novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors

Huang, H.; Hutta, D. A.; Rinker, J. M.; Hu, H.; Parsons, W. H.; Schubert, C.; DesJarlais, R. L.; Crysler, C. S.; Chaikin, M. A.; Donatelli, R. R.; Chen, Y.; Cheng, D.; Zhou, Z.; Yurkow, E.; Manthey, C. L.; Player, M. R.; J. Med. Chem., 2009, 52(4), 1081-1099

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Quinazolinones, Quinazolinthiones, and Quinazolinimines as Nitric Oxide Synthase Inhibitors: Synthetic Study and Biological Evaluation

Camacho, M. E. et al.; Arch. Pharm. Chem. Life Sci., 2016, 349, 638-650

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Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines

Labes, R. et al.; Synlett, 2017, 28(20), 2855-2858

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Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform

Desai, B.; Dixon, K.; Farrant, E.; Feng, Q.; Gibson, K. R.; van Hoorn, W. P.; Mills, J.; Morgan, T.; Parry, D. M.; Ramjee, M. K.; Selway, C. N.; Tarver, G. J.; Whitlock, G.; Wright, A. G.; J. Med. Chem., 2013, 56(7), 3033-3047

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Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

Liang, S. H.; Collier, T. L.; Rotstein, B. H.; Lewis, R.; Steck, M.; Vasdev, N.; Chem. Commun., 2013, 49(78), 8755-8757

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Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry

Ekholm, F. S.; Mandity, I. M.; Fulop, F.; Leino, R.; Tetrahedron Lett., 2011, 52, 1839-1841

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Rapid synthesis of substituted pyrrolines and pyrrolidines by nucleophilic ring closure at activated oximes

Chandan, N.; Thompson, A. L.; Moloney, M. G.; Org. Biomol. Chem., 2012, 10, 7863-7868

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Reaction screening in continuous flow reactors

Mohamed, D. K. B.; Yu, X.; Li, J.; Wu, J.; Reaction screening in continuous flow reactors; Tetrahedron Lett., 2016, 57, 3965-3977.

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ReactIR flow cell: a new analytical tool for continuous flow chemical processing

Carter, C. F.; Lange, H.; Ley, S. V.; Baxendale, I. R.; Wittkamp, B.; Goode, J. G.; Gaunt, N. L.; Org. Process Res. Dev., 2010, 14, 393-404

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Reactivation of catalysts for methanol-to-hydrocarbons conversion with hydrogen

Paunovic, V. et al.; Journal of Catalysis, 2022, 407, 54-64

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Reagent-controlled stereoselective synthesis of (±)-gallo- and (±)-epigallo-catechin gallates

Tanaka, H.; Chino, A.; Takahashi, T.; Tetrahedron Letters, 2012, 53, 2493-2495

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Rearrangement of N-alkyl 1,2-amino alcohols. Synthesis of (S)-toliprolol and (S)-propanolol

Duthion, B.; Metro, T.; Padro, D. G.; Cossy, J.; Tetrahedron, 2009, 65(33), 6696-6706

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Recent advances for serial processes of hazardous chemicals in fully integrated microfluidic systems

Singh, R.; Lee, H. J.; Singh, A. K.; Kim, D. P.; Korean Journal of Chemical Engineering, 2016, 33(8), 2253-2267

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Recent advances in asymmetric catalysis in flow

Zhao, D.; Ding, K.; ACS Catal., 2013, 3(5), 928-944

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Recent advances in micro reaction technology

Wiles, C.; Watts, P.; Chemical Communications, 2011, 47(23), 6512-6535

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Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules

Kopf, S. et al.; Chem. Rev., 2022, 122, 6634-6718

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Reconstruction of humins formation mechanism from decomposition products: A GC-MS study based on catalytic continuous flow depolymerizations

Filiciotto, L.; M. Balu, A.; Romero, A. A.; Angelici, C.; van der Waal, J. C.; Luque, R.; Mol. Cat., 2019, 479, 110564

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Recycling the waste: the development of a catalytic Wittig reaction

O'Brien, C. J.; Tellez, J. L.; Nixon, Z. S.; Kang, L. J.; Carter, A. L.; Kunkel, S. R.; Przeworski, K. C.; Chass, G. A.; Angew. Chem. Int. Ed., 2009, 48(37), 6836-6839

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Reductive amination in the synthesis of pharmaceuticals

Afanasyev, O. I.; Kuchuk, E.; Usanov, D. L.; Chusov, D.; Chem. Rev., 2019, accepted manuscript

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Reductive amination by continuous-flow hydrogenation: direct and scalable synthesis of a benzylpiperazine

Liu, J.; Fitzgerald, A. E.; Mani, N. S.; Synthesis, 2012, 44(15), 2469-2473

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Reductive amination of ketones: novel one-step transfer hydrogenations in batch and continuous-flow mode

Falus, P.; Boros, Z.; Hornyanszky, G.; Nagy, J.; Darvas, F.; Urge, L.; Poppe, L.; Tetrahedron Letters, 2011, 52, 1310-1312

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Regio-, diastereo-, and enantioselective nitroso-Diels–Alder reaction of 1,3-diene-1-carbamates catalyzed by chiral phosphoric acids

Pous, J.; Courant, T.; Bernadat, G.; Iorga, B. I.; Blanchard, F.; Masson, G.; J. Am. Chem. Soc., 2015, 137(37), 11950-11953

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Regioselective catalytic alkylation of N-heterocycles in continuous flow

Sipocz, T.; Lengyel., L.; Sipos, G.; Kocsis, L.; Dorman, Gy.; Jones, R. V.; Darvas, F.; J. Flow Chem., 2016, 6(2), 117-122

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Reissert indole synthesis using continuous-flow hydrogenation

Colombo, E.; Ratel, P.; Mounier, L.; Guillier, F.; J. Flow Chem., 2011, 2, 68-73

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Research spotlight: Microwave chemistry enabling the synthesis of biologically relevant amines

Spencer, J.; Future Med. Chem, 2010, 2(2), 161-168

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Reversal of the ee in enantioselective hydrogenation of activated ketones in continuous-flow fixed-bed reactor system

Cserenyi, Sz.; Szollosi, Gy.; Szori, K.; Fulop, F.; Bartok, M.; Catalysis Communications, 2010, 12, 14-19

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Reversible and efficient inhibition of UDP‐galactopyranose mutase by electrophilic, constrained and unsaturated UDP‐galactitol analogues

Ansiaux, C.; N'Go, I.; Vincent, S. P.; Chem. Eur. J., 2012, 18(46), 14860-14866

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Revisiting the deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions

Tshibalonza, N. N.; Monbaliu, J-C. M.; Green Chem., 2017, 19, 3006-3013

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Ruthenium and osmium complexes of novel carbohydrate derived salen ligands: Synthesis, characterization and in situ ligand reduction

Mandal, S.; Mandal, S.; Seth, D. K.; Mukhopadhyay, B.; Gupta, P.; Inorganica Chimica Acta, 2013, 398, 83-88

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Safe generation and synthetic utilization of hydrazoic acid in a continuous flow reactor

Gutmann, B.; Obermayer, D.; Roduit, J. P.; Roberge, D. M.; Kappe, C. O.; J. Flow Chem., 2012, 2(1), 8-19

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Safe hydrogenation of organic compounds and their property studies

Soung, M. J.; Woo, S. J.; Shin, D. J.; APEC Youth Scientist Journal, 2015, 7(1), 45-53

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Structure-activity relationship studies of mitogen activated protein kinase interacting kinase (MNK) 1 and 2 and BCR-ABL1 inhibitors targeting chronic myeloid leukemic cells

Cherian, J.; Nacro, K.; Poh, Z. Y.; Guo, S.; Jeyaray, D. A.; Wong, Y. X.; Ho, M.; Yang, H. Y.; Joy, J. K.; Kwek, Z. P.; Liu, B.; Wee, J. L. K.; Ong, E. H.; Choong, M. L.; Poulsen, A.; Lee, M. A.; Pendharkar, V.; Ding, L. J.; Manoharan, V.; Chew, Y. S.; Sangthongpitag, K.; Lim, S.; Ong, S. T.; Hill, J.; Keller, T. H.; J. Med. Chem., 2016, 59(7), 3063-3078

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SBA materials as support of iridium catalyst for hydrogenation reactions

Kiderys, A.; Kot, M.; Janiszewska, E.; Pietrowski, M.; Yang, C-M.; Zielinski, M.; Catalysis Today, 2019, accepted manuscript

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Scalable and straightforward synthesis of all isomeric (cyclo)alkylpiperidines

Subota, A. I.; Lutsenko, A. O.; Vashchenko, B. V.; Volochnyuk, D. M.; Levchenko, V.; Dmytriv, Y. V.; Rusanov, E. B.; Gorlova, A. O.; Ryabukhin, S. V.; Grygorenko, O. O.; Eur. J. Org. Chem., 2019, 2019(22), 3636-3648

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Scalable continuous flow hydrogenations using Pd/Al2O3-coated rectangular cross-section 3D-printed static mixers

Lebl, R. et al.; Catalysis Today, 2022, 383, 55-63

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Scalable synthesis of an integrin-binding peptide mimetic for biomedical applications

Riches, A. G.; Cablewski, T.; Glattauer, V.; Thissen, H.; Meagher, L.; Tetrahedron, 2012, 68(46), 9448-9455

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Scale-up of flow-assisted synthesis of C2-symmetric chiral PyBox ligands

Battilocchio, C.; Baumann, M.; Baxendale, I. R.; Biava, M.; Kitching, M. O.; Ley, S. V.; Martin, R. E.; Ohnmacht, S. A.; Tappin, N. D. C.; Synthesis, 2012, 4, 635-647

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Scale-up synthesis of a deuterium-labeled cis-cyclobutane-1,3-dicarboxylic acid derivative using continuous photo flow chemistry

Yamashita, T.; Nishikawa, H.; Kawamoto, T.; Tetrahedron, 2019, 75(5), 617-623

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Scaling up and validation of hydrogenation reactions using a continuous-flow microfluidics-based reactor, H-Cube®

Spadoni, C; Jones, R. V.; Urge, L.; Darvas, F.; Chemistry Today, 2006, January/February 2006, 38-41

Scrap waste automotive converters as efficient catalysts for the continuous-flow hydrogenations of biomass derived chemicals

Cova, C. M.; Zuliani, A.; Manno, R.; Sebastian, V.; Luque, R.; Green Chemistry, 2020, 22, 1414-1423

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Selective catalytic hydrogenations in a microfluidics-based high throughput flow reactor on ion-exchange supported transition metal complexes: A modular approach to the heterogenization of soluble complex catalysts

Horvath, H. H.; Papp, G.; Csajagi, Cs.; Joo, F.; Cat. Commun., 2007, 8, 442-446

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Selective continuous flow phenylacetylene hydrogenation over Pd-biogenic calcium carbonate

Chaparro, S. et al.; Catalysis Today, 2021, 368, 181-186

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Selective ensembles in supported palladium sulfide nanoparticles for alkyne semi-hydrogenation

Albani, D.; Shahrokhi, M.; Chen, Z.; Mitchell, S.; Hauert, R.; Lopez, N.; Perez-Ramirez, J.; Nature Communications, 2018, 9, article number: 2634

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Selective hydrodeoxygenation of acetophenone derivatives using a Fe25Ru75@SILP catalyst: a practical approach to the synthesis of alkyl phenols and anilines

Goclik, L. et al.; Green Chemistry, 2022, 24, 2937-2945

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Selective Hydrogenation of 5-Acetoxymethylfurfural over Cu-Based Catalysts in a Flow Reactor: Effect of Cu-Al Layered Double Hydroxides Synthesis Conditions on Catalytic Properties

Bukhtiyarova, M. V. et al.; Catalysts, 2022, 12, 878

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Selective liquid‐phase hydrogenation of a nitro group in substituted nitrobenzenes over Au/Al2O3 catalyst in a packed‐bed flow reactor

Nuzhdin, A. L.; Moroz, B. L.; Bukhtiyarova, G. A.; Reshetnikov, S. I.; Pyrjaev, P. A.; Aleksandrov P. V.; Bukhtiyarov, V. I.; ChemPlusChem, 2015, 80(12), 1741-1749

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Self-assembly of a helical zinc-europium complex: speciation in aqueous solution and luminescence

Deiters, E.; Eliseeva, S. V.; Bunzli, J. C. G.; Front. Chem., 2013, 1(15), 1-14

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Self-optimizing reactor systems: Algorithms, on‐line analytics, setups, and strategies for accelerating continuous flow process optimization

Fabry, D. C.; Sugiono, E.; Ruepig, M.; Isr. J. Chem., 2014, 54(4), 341-350

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Sequential nitration/hydrogenation protocol for the synthesis of triaminophloroglucinol: Safe generation and use of an explosive intermediate under continuous-flow conditions

Cantillo, D.; Damm, M.; Dallinger, D.; Bauser, M.; Berger, M.; Kappe, C. O.; Org. Process Res. Dev., 2014, 18(11), 1360-1366

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SiliaCat: A versatile catalyst series for synthetic organic chemistry

Ciriminna, R.; Pandarus, V.; Fidalgo, A.; Ilharco, L. M.; Beland, F.; Pagliaro, M.; Org. Process Res. Dev., 2015, 19(7), 755-768

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Single-atom heterogeneous catalysts based on distinct carbon nitride scaffolds

Chen, Z.; Vorobyeva, E.; Mitchell, S.; Fako, E.; Lopez, N.; Collins, S. M.; Leary, R. K.; Midgley, P. A.; Hauert, R.; Perez-Ramirez, J.; National Science Review, 2018, 5(5), 642-652

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Single operation stereoselective synthesis of Aerangis lactones: Combining continuous flow hydrogenation and biocatalysts in a chemoenzymatic sequence

Fink, M. J.; Schon, M.; Rudroff, F.; Schnurch, M.; Mihovilovic, M. D.; ChemCatChem, 2013, 5, 724-727

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Site‐selective deuterated‐alkene synthesis with palladium on boron nitride

Yabe, Y.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Chem. Eur. J., 2013, 19, 484-488

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Small-Molecule Inhibitors of the NusB−NusE Protein−Protein Interaction with Antibiotic Activity

Cossar, P. J. et al.; ACS Omega, 2017, 2, 3839-3857

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Solvent-free continuous operations using small footprint reactors: A key approach for process intensification

Ouchi, T.; Mutton, R. J.; Rojas, V.; Fitzpatrick, D. E.; Cork, D. G.; Battilocchio, C.; Ley, S. V.; ACS Sustainable Chem. Eng., 2016, 4, 1912-1916

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Solvent-free enzymatic process for biolubricant production in continuous microfluidic reactor

Madarasz, J.; Nemeth, D.; Bakos, J.; Gubicza, L.; Bakonyi, P.; Journal of Cleaner Production, 2015, 93, 140-144

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Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control

Voltrova, S.; Srogl, J.; Org. Chem. Front., 2014, 1, 1067-1071

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Spirocyclic dihydropyridines by electrophile-induced dearomatizing cyclization of N-alkenyl pyridinecarboxamides

Senczyszyn, J.; Brice, H.; Clayden, J.; Org. Lett., 2013, 15(8), 1922-1925

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Stepwise aromatic nucleophilic substitution in continuous flow. Synthesis of an unsymmetrically substituted 3,5-diamino-benzonitrile library

Lengyel, L.; Gyollai, V.; Nagy, T.; Dorman, G.; Terleczky, P.; Hada, V.; Nogradi, K.; Sebok, F.; Urge, L.; Darvas, F.; Mol. Divers., 2011, 15(3), 631-638

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Stereo‐ and chemoselective character of supported CeO2 catalysts for continuous‐flow three‐phase alkyne hydrogenation

Vile, G.; Wrabetz, S.; Floryan, L.; Schuster, M. E.; Girgsdies, F.; Teschner, D.; Perez-Ramirez, J.; ChemCatChem, 2014, 6(7), 1928-1934

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Stereocontrolled synthesis of the cis‐hydroxydecalin system: Towards biologically active 19‐nor‐clerodanes

Mirzayans, P. M.; Pouwer, R. H.; Williams, C. M.; Bernhardt, P. V.; Eur. J. Org. Chem., 2012, 2012(8), 1633-1638

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Stereoselective approaches to 2,3,6-trisubstituted piperidines. An enantiospecific synthesis of quinolizidine (−)-217A

Mancey, N. C.; Sandon, N.; Auvinet, A. L.; Butlin, R. J.; Czechtizky, W.; Harrity, J. P. A.; Chem. Commun., 2011, 47(35), 9804-9806

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Stereoselective catalytic synthesis of active pharmaceutical ingredients in homemade 3D‐printed mesoreactors

Rossi, S.; Porta, R.; Brenna, D.; Puglisi, A.; Benaglia, M.; Angew. Chem. Int. Ed., 2017, 56(15), 4290-4294

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Stereoselective metal‐free reduction of chiral imines in batch and flow mode: a convenient strategy for the synthesis of chiral active pharmaceutical ingredients

Brenna, D.; Benaglia, M.; Porta, R.; Fernandes, S.; Burke, A. J.; Eur. J. Org. Chem., 2017, 2017(1), 39-44

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Stereoselective reduction of prochiral cyclic 1,3-diketones using different biocatalysts

Contente, M. L.; Dall’Oglio, F.; Annunziata, F.; Molinari, F.; Rabuffetti, M.; Romano, D.; Tamborini, L.; Rother, D.; Pinto, A.; Catalysis Letters, 2019, accepted manuscript

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Stereoselective syntheses and transformations of chiral 1,3-aminoalcohols and 1,3-diols derived from nopinone

Szakonyi, Zs.; Gonda, T.; Otvos, S. B.; Fulop, F.; Tetrahedron: Asymmetry, 2014, 25, 1138-1145

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Stereoselective total synthesis of the marine macrolide sanctolide A

Yadav, J. S.; Suresh, B.; Srihari, P.; Eur. J. Org. Chem., 2015, 2015(26), 5856-5863

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Straightforward hetero Diels-Alder reactions of nitroso dienophiles by microreactor technology

Monbaliu, J-C. M. R.; Cukalovic, A.; Marchand-Brynaert, J.; Stevens, C. V.; Tetrahedron Letters, 2010, 51, 5830-5833

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Structural identification of petroleum acids by conversion to hydrocarbons and multidimensional gas chromatography-mass spectrometry

Wilde, M. J.; Rowland S. J.; Analytical Chemistry, 2015, 87(16), 8457-8465

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Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives

Bazin, H. G.; Li, Y.; Khalaf, J. K.; Mwakwari, S.; Livesay, M. T.; Evans, J. T.; Johnson, D. A.; Bioorg. Med. Chem. Lett., 2015, 25(6), 1318-1323

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Structural studies of the O-acetyl-containing O-antigen from a Shigella flexneri serotype 6 strain and synthesis of oligosaccharide fragments thereof

Chassagne, P.; Fontana, C.; Guerreiro, C.; Gauthier, C.; Phalipon, A; Widmalm, G.; Mulard, L. A.; Eur. J. Org. Chem., 2013, 2013(19), 4085-4106

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Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening

Ancellin, N. et al.; J. Med. Chem., 2016, 59, 2452-2467

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Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents

Ng, P. S.; Manjunatha, U. H.; Rao, S. P. S.; Camacho, L. R.; Ma, N. L.; Herve, M.; Noble, C. G.; Goh, A.; Peukert, S.; Diagana, T. T.; Smith, P. W.; Kondreddi, R. R.; Eur. J. Med. Chem., 2015, 106, 144-156

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Structure and reactivity of supported hybrid platinum nanoparticles for the flow hydrogenation of functionalized nitroaromatics

Vile, G.; Almora-Barrios, N.; Lopez, N.; Perez-Ramirez, J.; ACS Catal., 2015, 5(6), 3767-3778

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Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase

Nichols, D. A.; Jaishankar, P.; Larson, W.; Smith, E.; Liu, G.; Beyrouthy, R.; Bonnet, R.; Renslo, A. R.; Chen, Y.; J. Med. Chem., 2012, 55(5), 2163-2172

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Structure-based optimization of naphthyridones into potent ATAD2 bromodomain inhibitors

Bamborough, P.; Chung, C.; Furze, R. C.; Grandi, P.; Michon, A.; Sheppard, R. J.; Barnett, H.; Diallo, H.; Dixon, D. P.; Douault, C.; Jones, E. J.; Karamshi, B.; Mitchell, D. J.; Prinjha, R. K.; Rau, C.; Watson, R. J.; Werner, T.; Demont, E. H.; J. Med. Chem., 2015, 58(15), 6151-6178

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Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential

Coteron, J. M.; Marco, M.; Esquivias, J.; Deng, X.; White, K. L; White, J.; Koltun, M.; Mazouni, F. E.; Kokkonda, S.; Katneni, K.; Bhamidipati, R.; Shackleford, D. M.; Angulo-Barturen, I.; Ferrer, S. B.; Jimenez-Diaz, M. B.; Gamo, F. J.; Goldasmith, E. J.; Charman, W. N.; Bathurst, I.; Floyd, D.; Matthews, D.; Burrows, J. N.; Rathod, P. K.; Charman, S. A.; Philips, M. A; J. Med. Chem., 2011, 54(15), 5540-5561

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Structuring hybrid palladium nanoparticles in metallic monolithic reactors for continuous-flow three-phase alkyne hydrogenation

Albani, D.; Vile, G.; Toro, M. A. B.; Kaufmann, R.; Mitchell, S.; Perez-Ramirez, J.; React. Chem. Eng., 2016, 1, 454-462

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Studies of long chain lipids in insects by high temperature gas chromatography and high temperature gas chromatography–mass spectrometry

Sutton, P. A.; Wilde, M. J.; Martin, S. J.; Cvacka, J.; Vrkoslav, V.; Rowland, S. J.; Journal of Chromatography A, 2013, 1297, 236-240

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Studies on the continuous-flow synthesis of nonpeptidal bis-tetrahydrofuran moiety of Darunavir

Leao, R. A. C.; Lopes, R. de O.; de M. Bezerra, M. A.; Muniz, M. N.; Casanova, B. B.; Gnoatto, S. C. B.; Gosmann, G.; Kocsis, L.; de Souza, R. O. M. A.; de M. Miranda, L. S.; Journal of Flow Chemistry, 2015, 5(4), 216-219

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Studies on the synthesis of the lasubine alkaloids

Aslam, N. F. M.; Simon, O.; Bates, R. W.; Tetrahedron, 2018, 74(38), 5032-5039

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Substrate engineering: Effects of different N-protecting groups in the CAL-B-catalysed asymmetric O-acylation of 1-hydroxymethyl-tetrahydro-β-carbolines

Megyesi, R.; Forro, E.; Fulop, F.; Tetrahedron, 2018, 74(21), 2634-2640

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Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer’s Disease

Rossi, M. et al.; J. Med. Chem., 2021, 64(8), 4972-4990

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Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4

Brown, A. W. et al.; J. Med. Chem., 2016, 59, 9473-9488

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Synergistic interaction within bifunctional ruthenium nanoparticle/SILP catalysts for the selective hydrodeoxygenation of phenols

Luska, K. L.; Migowski, P.; El Sayed, S.; Leitner, W.; Angew. Chem., 2015, 127(52), 15976-15981

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Syntheses of 4-, 5-, 6-, and 7-substituted tryptamine derivatives and the use of a bromine atom as a protecting group

Rene, O.; Fauber, B. P.; Tetrahedron Letters, 2014, 55(4), 830-833

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Syntheses of four enantiomers of 2,3-diendo- and 3-endo-aminobicyclo[2.2.2]oct-5-ene-2-exo-carboxylic acid and their saturated analogues

Palko, M.; Hanninen, M. M.; Sillanpaa, R.; Fulop, F.; Molecules, 2013, 18(12), 15080-15093

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Synthesis and activity of putative small-molecule inhibitors of the F-Box protein SKP2

Shouksmith, A. E.; Evans, L. E.; Tweddle, D. A.; Miller, D. C.; Willmore, E.; Newell, D. R.; Golding, B. T.; Griffin, R. J.; Aust. J. Chem., 2015, 68(4), 660-679

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Synthesis and anticancer activity of a series of norcantharidin analogues

Tarleton, M.; Gilbert, J.; Sakoff, J. A.; McCluskey, A.; Eur. J. Med. Chem., 2012, 54, 573-581

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Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease

Alexandre, F-R.; Brandt, G.; Caillet, C.; Chaves, D.; Convard, T.; Derock, M.; Gloux, D.; Griffon, Y.; Lallos, L.; Leroy, F.; Liuzzi, M.; Loi, A-G.; Moulat, L.; Musiu, C.; Parsy, C.; Rahali, H.; Roques, V.; Seifer, M.; Standring, D.; Surleraux, D.; Bioorg. Med. Chem. Lett., 2015, 25(18), 3984-3991

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Synthesis and arylation of unprotected sulfonimidamides

Maldonado; M. F.; Sehgelmeble, F.; Bjarnemark, F.; Svensson, M.; Ahman, F.; Arvidsson, P. I.; Tetrahedron, 2012, 68, 7456-7462

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Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins

McCarthy, A. R.; Pirrie, L.; Hollick, J. J.; Ronseaux, S.; Campbell, J.; Higgins, M.; Staples, O. D.; Tran, F.; Slawin, A. M. Z.; Lain, S.; Westwood, N. J.; Bioorg. Med. Chem., 2012, 20, 1779-1793

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Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

Spencer, J.; Rathnam, R. P.; Harvey, A. L.; Clements, C. J.; Clark, R. L.; Barrett, M. P.; Wong, P. E.; Male, L.; Coles, S. J.; Mackay, S. P.; Bioorg. Med. Chem., 2011, 19, 1802-1815

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Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents

Marhadour, S.; Marchand, P.; Pagniez, F.; Bazin, M. A.; Picot, C.; Lozach, O.; Ruchaud, S.; Antoine, M.; Meijer, L.; Rachidi, N.; Le Pape, P.; Eur. J. Med. Chem., 2012, 58, 543-556

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Synthesis and biological evaluation of an orally active glycosylated endomorphin-1

Varamini, P.; Mansfeld, F. M.; Blanchfield, J. T.; Wyse, B. D.; Smith, M. T.; Toth, I.; J. Med. Chem., 2012, 55(12), 5859-5867

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Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting αvβ3/αvβ5 integrins and IAP proteins

Mingozzi, M.; Manzoni, L.; Arosio, D.; Dal Corso, A.; Manzotti, M.; Innamorati, F.; Pignataro, L.; Lecis, D.; Delia, D.; Seneci, P.; Gennari, C.; Org. Biomol. Chem., 2014, 12, 3288-3302

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Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists

Batie, S.; Lee, J. H.; Jama, R. A:; Browder, D. O.; Montano, L. A.; Huynh, C. C.; Marcus, L. M.; Tsosie, D. G.; Mohammed, Z.; Trang, V.; Marshall, P. A.; Jurutka, P. W.; Wagner, C. E.; Bioorg. Med. Chem., 2013, 21, 693-702

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Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Lawrence, H. R.; Kazi, A.; Luo, Y.; Kendig, R.; Ge, Y.; Jain, S.; Daniel, K.; Santiago, D.; Guida, W. C.; Sebti, S. M.; Bioorg. Med. Chem., 2010, 18(15), 5576-5592

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Synthesis and biological evaluation of second-generation tropanol-based androgen receptor modulators

Sunden, H.; Holland, M. C.; Poutiainen, P. K.; Jaaskelainen, T.; Pulkkinen, J. T.; Palvimo, J. J.; Olsson, R.; J. Med. Chem., 2015, 58, 1569-1574

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Synthesis and cytotoxicity of octahydroepoxyisoindole-7-carboxylic acids and norcantharidin-amide hybrids as norcantharidin analogues

Hizartzidis, L.; Gilbert, J.; Gordon, C. P.; Sakoff, J. A.; McCluskey, A.; ChemMedChem, 2019, 14(12), 1152-1161

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Synthesis and photophysical characterization of 1- and 4-(purinyl)triazoles

Redwan, I. N.; Bliman, D.; Tokugawa, M.; Lawson, C.; Grotli, M.; Tetrahedron, 2013, 69(42), 8857-8864

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Synthesis and reactivity of 3-amino-1H-pyrazolo[4,3-c]pyridin-4(5H)-ones: development of a novel kinase-focussed library

Smyth, L. A.; Matthews, T. P.; Horton, P. N.; Hursthouse, M. B.; Collins, I.; Tetrahedron, 2010, 66, 2843-2854

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Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries

Spencer, J.; Patel, H.; Callear, S. K.; Coles, S. J.; Deadman, J. J.; Tetrahedron Letters, 2011, 52, 5905-5909

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Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase

Christoff, R. M. et al.; Bioorg. Med. Chem., 2021, 52, 116518

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Synthesis and structure–activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase

Luci, D. K.; Jameson, J. B.; Yasgar, A.; Diaz, G.; Joshi, N.; Kantz, A.; Markham, K., Perry, S.; Kuhn, N.; Yeung, J., Kerns, E. H.; Schultz, L.; Holinstat, M.; Nadler, J. L.; Taylor-Fishwick, D. A.; Jadhav, A.; Simeonov, A.; Holman, T. R.; Maloney, D. J.; J. Med. Chem., 2014, 57(2), 495-506

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Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer

Dexheimer, T. S.; Rosenthal, A. S.; Luci, D. K.; Liang, Q.; Villamil, M. A.; Chen, J.; Sun, H.; Kerns, E. H.; Simeonov, A.; Jadhav, a.; Zhuang, Z.; Maloney, D. J.; J. Med. Chem., 2014, 57(19), 8099-8110

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Synthesis and structure–activity relationships of N‐(4‐benzamidino)‐oxazolidinones–potent and selective inhibitors of kallikrein‐related peptidase 6

De Vita, E.; Smits, N.; van den Hurk, H.; Beck, E. M.; Hewitt, J.; Baillie, G.; Russell, E.; Pannifer, A.; Hamon, V.; Morrison, A.; McElroy, S. P.; Jones, P.; Ignatenko, N.; Gunkel, N.; Miller, A. K.; ChemMedChem, 2019, accepted manuscript

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Synthesis and structure–activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors

Ponzano, S.; Bertozzi, F.; Mengatto, L.; Dionisi, M.; Armirotti, A.; Romeo, E.; Berteotti, A.; Fiorelli, C.; Tarozzo, G.; Reggiani, A.; Duranti, A.; Tarzia, G.; Mor, M.; Cavalli, A.; Piomelli, D.; Bandiera, T.; J. Med. Chem., 2013, 56(17), 6917-6934

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Synthesis, anti‐tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones

Leese, M. P.; Jourdan, F. L.; Major, M. R.; Dohle, W.; Thomas, M. P.; Hamel, E.; Ferrandis, E.; Mahon, M. F.; Newman, S. P.; Purohit, A.; Potter, B. V. L.; ChemMedChem, 2014, 9, 798-812

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Synthesis, antitubulin, and antiproliferative SAR of C3/C1‐substituted tetrahydroisoquinolines

Dohle, W.; Leese, M. P.; Jourdan, F. L.; Major, M. R.; Bai, R.; Hamel, E.; Ferrandis, E.; Kasprzyk, P. G.; Fiore, A.; Newman, S. P.; Purohit, A.; Potter, B. V. L.; ChemMedChem, 2014, 9, 350-370

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Synthesis, biological evaluation, and molecular modeling of new 3‑(cyclopentyloxy)-4-methoxybenzaldehyde O‑(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) related phosphodiesterase 4D (PDE4D) inhibitors

Brullo, C.; Massa, M.; Rocca, M; Rotolo, C.; Guariento, S.; Rivera, D.; Ricciarelli, R.; Fedele, E.; Fossa, P.; Bruno, O.; J. Med. Chem., 2014, 57(16), 7061-7072

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Synthesis, biological evaluation, and utility of fluorescent ligands targeting the μ-opioid receptor

Schembri, L. S.; Stoddart, L. A.; Briddon, S. J.; Kellam, B.; Canals, M.; Graham, B.; Scammells, P. J.; J. Med. Chem., 2015, 58(24), 9754-9767

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Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging

Andres, J. I.; Alcazar, J.; Cid, J. M.; De Angelis, M., Iturrino, L.; Langlois, X.; Lavreysen, H.; Trabanco, A. A.; Celen, S.; Bormans, G.; J. Med. Chem., 2012, 55, 8685-8699

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Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging

Andres, J-I.; De Angelis, M.; Alcazar, J.; Iturrino, L.; Langlois, X.; Dedeurwaerdere, S.; Lenaerts, I.; Vanhoof, G.; Celen, S.; Bormans, G.; J. Med. Chem., 2011, 54, 5820-5835

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Synthesis of 12β-Methyl-18-nor-bile Acids

Luxenburger, A. et al.; ACS Omega, 2021, 6(38), 25019-25039

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Synthesis of 2,6-Dimethyltyrosine-Like Amino Acids through Pinacolinamide-Enabled C-H Dimethylation of 4-Dibenzylamino Phenylalanine

Illuminati, D. et al.; J. Org. Chem., 2022, 87, 5, 2580-2589

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Synthesis of 3-arylated 3,4-dihydrocoumarins: Combining continuous flow hydrogenation with laccase-catalysed oxidation

Suljic, S.; Pietruszka, J.; Adv. Synth. Catal., 2014, 356(5), 1007-1020

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Synthesis of 3-nitropyrrolidines via dipolar cycloaddition reactions using a modular flow reactor

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Synlett, 2010, 5, 749-752

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Synthesis of 3‐Hydroxypipecolic Acids

Cochi, A.; Pardo, D. G.; Cossy, J.; Eur. J. Org. Chem., 2013, 2013(5), 809-829

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Synthesis of 4-fluoromethylsydnones and their participation in alkyne cycloaddition reactions

Foster, R. S.; Adams, H.; Jakobi, H.; Harrity, J. P. A.; J. Org. Chem., 2013, 78(8), 4049-4064

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Synthesis of 5‐bromomethylfurfural from cellulose as a potential intermediate for biofuel

Kumari, N.; Olesen, J. K.; Pedersen, C. M.; Bols, M.; Eur. J. Org. Chem., 2011, 2011(7), 1266-1270

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Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state

Baltus, C. B.; Press, N. J.; Antonijevic, M. D.; Tizzard, G. J.; Coles, S. J.; Spencer, J.; Tetrahedron, 2012, 68(45), 9272-9277

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Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods

Baumann, M.; Baxendale, I. R.; Kuratli, C.; Ley, S. V.; Martin, R. E.; Schneider, J.; ACS Comb. Sci., 2011, 13(4), 405-413

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Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states

Dayde, B.; Benzaria, S.; Pierra, C.; Gosselin, G.; Surleraux, D.; Volle, J.; Pirat, J.; Virieux, D.; Org. Biomol. Chem, 2012, 10, 3448-3454

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Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate

Howard, P. W.; Chen, Z.; Gregson, S. J.; Masterson, L. A.; Tiberghien, A. C.; Cooper, N.; Fang, M.; Coffils, M. J.; Klee, S.; Hartley, J. A.; Thurston, D. E.; Bioorg. Med. Chem. Lett. 2009, 19(22), 6463-6466

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Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki–Miyaura cross-couplings

Spencer, J.; Baltus, C. B.; Press, N. J.; Harrington, R. W.; Clegg, W.; Tetrahedron Letters, 2011, 52(31), 3963-3968

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Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope

Simerska, P.; Lu, H.; Toth, I.; Bioorg. Med. Chem. Lett., 2009, 19(3), 821-824

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Synthesis of a tetrasaccharide related to the triterpenoid saponin Bellisoside isolated from Bellis perennis (compositae)

Mandal, S.; Sharma, N.; Mukhopadhyay, B.; Tetrahedron: Asymmetry, 2010, 21, 2172-2176

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Synthesis of amines from alcohols in a nonepimerizing one-pot sequence – Synthesis of bioactive compounds: Cinacalcet and dexoxadrol

Guerin, C.; Bellosta, V.; Guillamot, G.; Cossy, J.; Eur. J. Org. Chem., 2012, 15, 2990-3000

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Synthesis of an azabicyclic framework towards (±)-actinophyllic acid

Mortimer, D.; Whiting, M.; Harrity, J. P. A.; Jones, S.; Coldham, I.; Tetrahedron Letters, 2014, 55, 1255-1257

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Synthesis of an undecasaccharide featuring an oligomannosidic heptasaccharide and a bacterial Kdo-lipid A backbone for eliciting neutralizing antibodies to mammalian oligomannose on the HIV-1 envelope spike

Trattnig, N.; Blaukopf, M.; Bruxelle, J-F.; Pantophlet, R.; Kosma, P.; JACS, 2019, 141(19), 7946-7954

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Synthesis of aromatic 13C/2H-α-ketoacid precursors to be used in selective phenylalanine and tyrosine protein labelling

Lichtenecker, R. J.; Org. Biomol. Chem., 2014, 12, 7551-7560

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Synthesis of benzannulated spiroketals using an oxidative radical cyclization

Sperry, J.; Liu, Y-C.; Wilson, Z. E.; Hubert, J. G.; Brimble, M. A.; Synthesis, 2011, 9, 1383-1398

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Synthesis of bioderived cinnolines and their flow-based conversion into 1,4-dihydrocinnoline derivatives

Devlin, J.; Clogher, R.; Baumann, M.; Synlett, 2019, accepted manuscript

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Synthesis of bivalent lactosides based on terephthalamide, N,N-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins

Leyden, R.; Velasco-Torrijos, T.; Andre, S.; Gouin, S.; Gabius, H-J.; Murphy, P. V.; J. Org. Chem., 2009, 74(23), 9010-9026

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Synthesis of Chalcones Derivatives and Their Biological Activities: A Review

Elkanzi, N. A. A. et al.; ACS Omega, 2022, 7, 27769-27786

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Synthesis of condensed heterocycles by the Gould-Jacobs reaction in a novel three-mode pyrolysis reactor

Lengyel, L. C.; Sipos, G.; Sipocz, T.; Vago, T.; Dorman, G.; Gerencser, J.; Makara, G.; Darvas, F.; Org. Process Res. Dev., 2015, 19(3), 399-409

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Synthesis of cross‐linked glycopeptides and ureas by a mechanochemical, solvent‐free reaction and determination of their structural properties by TEM and X‐ray crystallography

Kumar, V.; Giri, S. K.; Venugopalan, P.; Kartha, K. P. R.; ChemPlusChem, 2014, 79(11), 1605-1613

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Synthesis of four (4″-, 2″-, 2′-, and 6-) monodeoxy analogs of the trisaccharide α-d-Glcp-(1→3)-α-d-Manp-(1→2)-α-d-ManpOMe recognized by Calreticulin/Calnexin

Glinschert, A.; Oscarson, S.; Carbohydrate Research, 2015, 414, 65-71

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Synthesis of functionalized 3-hydroxypiperidines

Wijdeven, M. A.; van Delft, F. L.; Rutjes, F. P. J. T.; Tetrahedron, 2010, 66, 5623-5636

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Synthesis of Fused Pyrimidinone and Quinolone Derivatives in an Automated High Temperature and High Pressure Flow Reactor

Tsoung, J. et al.; J. Org. Chem., 2017, 82, 1073-1084

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Synthesis of Highly Functionalized 4-Aminoquinolines

Wezeman, T. et al.; Angew. Chem. Int. Ed., 2016, 55, 3823-3827

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Synthesis of highly substituted nitropyrrolidines, nitropyrrolizines and nitropyrroles via multicomponent-multistep sequences within a flow reactor

Baumann, M.; Baxendale, I. R.; Kirschning, A.; Ley, S. V.; Wegner, J.; Heterocycles, 2011, 82(2), 1297-1316

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Synthesis of hydroxylated pyrrolidines by allenic cyclisation

Ng, P. S. et al.; Tetrahedron, 2016, 72, 6356-6362

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Synthesis of α-substituted vinylsulfonium salts and their application as annulation reagents in the formation of epoxide- and cyclopropane-fused heterocycles

Matlock, J. V.; Fritz, S. P.; Harrison, S. A.; Coe, D. M.; McGarrigle, E. M.; Aggarwal, V. K.; J. Org. Chem., 2014, 79, 10226-10239

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Synthesis of L-[5-11C]Leucine and L-α-[5-11C]Methylleucine via Pd0-mediated 11C-Methylation and Microfluidic Hydrogenation: Potentiality of Leucine PET Probes for Tumor Imaging

Takatani, S. et al.; ChemMedChem, 2021, 16(21), 3271-3279

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Synthesis of laminarin fragments and evaluation of a β-(1,3) glucan hexasaccaride-CRM197 conjugate as vaccine candidate against Candida albicans

Adamo, R.; Tontini, M.; Brogioni, G.; Romano, M. R.; Contantini, G.; Danieli, E.; Proietti, D.; Berti, F.; Constantino, P.; Journal of Carbohydrate Chemistry, 2011, 30, 249-280

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Synthesis of macrolide-saccharide hybrids by ring-closing metathesis of precursors derived from glycitols and benzoic acids

Matos, M-C.; Murphy, P. V.; J. Org. Chem., 2007, 72, 1803-1806

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Synthesis of Mepivacaine and Its Analogues by a Continuous-Flow Tandem Hydrogenation/Reductive Amination Strategy

Suveges, N. S. et al.; Eur. J. Org. Chem., 2017, 6511-6517

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Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors

Tite, T.; Tomas, L.; Docsa, T.; Gergely, P.; Kovensky, J.; Gueyrard, D.; Wadouachi, A.; Tetrahedron Letters, 2012, 53, 959-961

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Synthesis of N-hydroxypyrazin-2(1H)-ones via selective O-debenzylation of 1-benzyloxypyrazin-2(1H)-ones using flow methodology

Mai, A. H.; De Borggraeve, W. M.; J. Flow Chem., 2015, 5(1), 6-10

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Synthesis of N-propynyl analogues of peptide nucleic acid (PNA) monomers and their use in the click reaction to prepare N-functionalized PNAs

Howarth, N. M.; Ricci, J.; Tetrahedron, 2011, 67, 9588-9594

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Synthesis of natural and unnatural cyclooligomeric depsipeptides enabled by flow chemistry

Lucke, D.; Dalton, T.; Ley, S. V.; Wilson Z. E.; Chem. Eur. J., 2016, 22(12), 4206-4217

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Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds

Joyard, Y.; Azzouz, R.; Bischoff, L.; Papamicael, C.; Labar, D.; Bol, A.; Bol, V.; Vera, P.; Gregoire, V.; Levacher, V.; Bohn, P.; Bioorg. Med. Chem., 2013, 21, 3680-3688

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Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity

Borcard, F.; Baud, M.; Bello, C.; Dal Bello, G.; Grossi, F.; Pronzato, P.; Cea, M.; Nencioni, A.; Vogel, P.; Bioorg. Med. Chem. Lett., 2010, 20(17), 5353-5356

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Synthesis of Novel Camphor-Derived Bifunctional Thiourea Organocatalysts

Ricko, S.; Golobic, A.; Svete, J.; Stanovnik, B.; Groselj, U.; Chirality, 2015, 27(1), 39-52

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Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups and their evaluation as antimicrobial agents

Workman, D. G.; Hunter, M.; Dover, L. G.; Tetard, D.; Journal of Inorganic Biochemistry, 2016, 160, 49-58

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Synthesis of oxaspiropiperidines as a strategy for lowering logD

Cernak, T.; Dykstra, K.; Levorse, D.; Verras, A.; Balkovec, J.; Nargund, R.; DeVita, R.; Tetrahedron Letters, 2011, 52, 6457-6459

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Synthesis of phenols via fluoride-free oxidation of arylsilanes and arylmethoxysilanes

Rayment, E. J.; Summerhill, N.; Anderson, E. A.; J. Org. Chem., 2012, 77(16), 7052-7060

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Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations

Baumann, M.; Baxendale, I. R.; Hornung, C. H.; Ley, S. V.; Rojo, M. V; Roper, K. A.; Molecules, 2014, 19(7), 9736-9759

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Synthesis of spirocyclic thiazolidinediones using ring-closing metathesis and one-pot sequential ring-closing/cross metathesis

Dhara, K.; Paladhi, S.; Midya, G. C.; Dash, J.; Org. Biomol. Chem., 2011, 9, 3801-3807

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Synthesis of Staphylococcus aureus type 5 capsular polysaccharide repeating unit using novel L-FucNAc and D-FucNAc synthons and immunochemical evaluation

Danieli, E.; Proietti, D.; Brogioni, G.; Romano, M. R.; Cappelletti, E.; Tontini, M.; Berti, F.; Lay, L.; Costantino, P.; Adamo, R.; Bioorg. Med. Chem., 2012, 20, 6403-6415

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Synthesis of sugar-lactams from azides of glucuronic acid

Loukou, C.; Tosin, M.; Muller-Bunz, H.; Murphy, P. V.; Carbohydrate Research, 2007, 342(12-13), 1953-1959

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Synthesis of symmetric dinitro‐functionalised Tröger’s base analogues

Bhuiyan, M. D. H.; Mahon, A. B.; Jensen, P.; Clegg, J. K.; Try, A. C.; Eur. J. Org. Chem., 2009, 5, 687-698

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Synthesis of 2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane (TAIW) from 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazaisowurtzitane (TADBIW) by catalytic hydrogenolysis using a continuous flow process

Dong, K.; Sun, C. H.; Song, J. W., Wei, G. X.; Pang, S. P.; Org. Process Res. Dev., 2014, 18, 1321-1325

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Synthesis of tetrazole analogues of amino acids using Fmoc chemistry: isolation of amino free tetrazoles and their incorporation into peptides

Sureshbabu, V. V.; Venkataramanarao, R.; Naik, S. A.; Chennakirshnareddy, G.; Tetrahedron Letters, 2007, 48(39), 7038-7041

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Synthesis of the tetrasaccharide repeating unit of the β-Kdo-containing exopolysaccharide from Burkholderia pseudomallei and B. cepacia complex

Laroussarie, A.; Barycza, B.; Andriamboavonjy, H.; Kenfack, M. T.; Bleriot, Y.; Gauthier, C.; J. Org. Chem., 2015, 80(20), 10386-10396

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Synthesis of the tetrasaccharide repeating unit of the O-glycan from the polar flagellum flagellin of Azospirillum brasilense Sp7

Pal, K. B.; Mukhopadhyay, B.; Carbohydrate Research, 2014, 400, 9-13

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Synthesis of the trisaccharide repeating unit of the lipopolysaccharide from Moritella viscosa strain M2-226

Pal, K. B.; Verma, P. R.; Gupta, T.; Mukhopadhyay, B.; Journal of Carbohydrate Chemistry, 2015, 34(4), 173-182

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Synthesis of two trisaccharides related to the hepatoprotective phenylethanoids leonoside E and F isolated from Leonurus japonicus Houtt

Budhadev, D.; Mukhopadhyay, B.; Carbohydrate Research, 2014, 384, 51-55

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Synthesis of unique scaffolds via Diels-Alder cycloadditions of tetrasubstituated cyclohexadienes

Jones, A. L.; Snyder, J. K.; Organic Letters, 2010, 12(7), 1592-1595

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Synthesis of unsaturated secondary amines by direct reductive amination of aliphatic aldehydes with nitroarenes over Au/Al2O3 catalyst in continuous flow mode

Artiukha, E. A. et al.; RSC Adv., 2016, 6, 88366-88372

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Synthesis of γ-valerolactone using a continuous-flow reactor

Tukacs, J. M.; Jones, R. V.; Darvas, F.; Dibo, G.; Lezsak, G.; Mika, L. T.; RSC Adv., 2013, 3, 16283-16287

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Synthesis, Properties, and Two-Dimensional Adsorption Characteristics of [6]Hexahelicene-7-carboxylic acid

van der Meijden, M. W. et al.; Chem. Eur. J., 2016, 22, 14633-14639

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Synthesis, SAR, and pharmacological characterization of brain penetrant P2X7 receptor antagonists

Savall, B. M.; Wu, D.; Angelis, M. D.; Carruhters, N. I.; Ao, H.; Wang, Q.; Lord, B.; Bharrachrya, A.; Letavic, M. A.; ACS Med. Chem. Lett., 2015, 6, 671-676

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Synthesis, structure–activity, and structure–stability relationships of 2‐substituted‐N‐(4‐oxo‐3‐oxetanyl) N‐acylethanolamine acid amidase (NAAA) inhibitors

Vitale, R.; Ottonello, G.; Petracca, R.; Bertozzi, S. M.; Ponzano, S.; Armirotti, A.; Berteotti, A.; Dionisi, M.; Cavalli, A.; Piomelli, D.; Bandiera, T.; Bertozzi, F.; ChemMedChem, 2014, 9, 323-336

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Synthetic multivalent ligands for cholera & cholera-like toxins: Protected cyclic neoglycopeptides

Kumar, V.; Yadav, N.; Kartha, K. P. R.; Carbohydrate Research, 2016, 431, 47-55

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Synthetic studies toward the C32–C46 segment of hemicalide. Assignment of the relative configuration of the C36–C42 subunit

Specklin, S.; Boissonnat, G.; Lecourt, C.; Sorin, G.; Lannou, M. I.; Ardisson, J.; Sautel, F.; Massiot, G.; Meyer, C.; Cossy, J.; Org. Lett., 2015, 17(10), 2446-2449

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Systematic evaluation of the palladium-catalyzed hydrogenation under flow conditions

Hattori, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Tetrahedron, 2014, 70(32), 4790-4798

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Tailoring nitrogen-doped carbons as hosts for single-atom catalysts

Buchele, S.; Chen, Z.; Mitchell, S.; Hauert, R.; Krumeich, F.; Perez-Ramirez, J.; ChemCatChem, 2019, 11(12), 2812-2820

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Taming hazardous chemistry by continuous flow technology

Movsisyan, M.; Delbeke, E. I. P.; Berton, J. K. E. T.; Battilocchio, C.; Ley, S. V.; Stevens, C. V.; Chem. Soc. Rev., 2016, 45, 489-4928

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Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry

Buglioni, L. et al.; Chem. Rev., 2022, 122, 2752-2906

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Telescoped sequence of exothermic and endothermic reactions in multistep flow synthesis

Sharma, Y.; Nikam, A. V.; Kulkarni, A. A.; Org. Process Res. Dev., 2018, 23(2), 170-176

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Tetrahydroisoquinolinone‐based steroidomimetic and chimeric microtubule disruptors

Leese, M. P.; Jourdan, F. L.; Major, M. R.; Dohle, W.; Hamel, E.; Ferrandis, E.; Fiore, A.; Kasprzyk, P. G.; Potter, B. V. L.; ChemMedChem, 2014, 9(1), 85-108

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The changing face of organic synthesis

Ley, S. V.; Baxendale, I. R.; Chimia, 2008, 62(3), 162-168

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The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors

Carter, C. F.; Baxendale, I. R.; Pavey, J. B. J.; Ley, S. V.; Org. Biomol. Chem., 2010, 8, 1588-1595

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The continuous synthesis and application of graphene supported palladium nanoparticles: a highly effective catalyst for Suzuki-Miyaura cross-coupling reactions

Brinkley, K. W.; Burkholder, M.; Siamaki, A. R.; Belecki, K.; Gupton, B. F.; Green Process. Synth., 2015, 4(3), 241-246

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The Cooperative Research Centre for Cancer Therapeutics: bridging the gap between leading cancer research at Australia’s universities and developing novel cancer drugs

Baell, J. B.; Heathers, G.; Sage, C.; Future Med. Chem., 2010, 2, 941-947

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The development of poly(dendrimer)s for advanced processing

Gunning, J. P.; Levell, J. W.; Wyatt, M. F.; Burn, P. L.; Robertson, J.; Samuel, I. D. W.; Polym. Chem., 2010, 1, 730-738

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The dual reactivity of Weinreb amides applied to the late-stage divergent functionalisation of meso pyrrolidines

Boufroura, H.; Sevaille, L.; Gigant, N.; Drege, E.; Joseph, D.; New J. Chem., 2018, 42, 12403-12411

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The expanding utility of continuous flow hydrogenation

Cossar, P. J.; Hizartzidis, L.; Simone, M. I.; McCluskey A.; Gordon, C. P.; Org. Biomol. Chem., 2015, 13, 7119-7130

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The first case of competitive heterogeneously catalyzed hydrogenation using continuous-flow fixed-bed reactor system: Hydrogenation of binary mixtures of activated ketones on Pt-alumina and on Pt-alumina-cinchonidine catalysts

Szollosi, G.; Makra, Z.; Fulop, F.; Bartok, M.; Catalysis Letters, 2011, 141, 1616-1620

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The flow synthesis of heterocycles for natural product and medicinal chemistry applications

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Molecular Diversity, 2011, 15(3), 613-630

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The future of organic synthesis

Kundig, P.; Science, 2006, 314, 430-431

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The identification of indacaterol as an ultralong-acting inhaled β2-adrenoceptor agonist

Baur, F.; Beattie, D.; Beer, D.; Bentley, D.; Bradley, M.; Bruce, I.; Charlton, S. J.; Cuenoud, B.; Ernst, R.; Fairhurst, R. A.; Faller, B.; Farr, D.; Keller, T.; Fozard, J. R.; Fullerton, J.; Garman, S.; Hatto, J.; Hayden, C.; He, H.; Howes, C.; Janus, D.; Jiang, Z.; Lewis, C.; Loeuillet-Ritzler, F.; Moser, H.; Reilly, J.; Steward, A.; Sykes, D.; Tedaldi, L.; Trifilieff, A.; Tweed, M.; Watson, S.; Wissler, E.; Wyss, D.; J. Med. Chem., 2010, 53, 3675-3684

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The influence of linkages between 1-Hydroxy-2(1H)-pyridinone Coordinating Groups and a Tris(2-aminoethyl)amine core in a novel series of synthetic Hexadentate Iron(III) Chelators on antimicrobial activity

Workman, D. G.; Hunter, M.; Wang, S.; Brandel, J.; Hubscher, V.; Dover, L. G.; Tetard, D.; Bioorg. Chem., 2019, accepted manuscript

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The integration of flow reactors into synthetic organic chemistry

Baxendale, I. R.; J. Chem. Technol. Biotechnol., 2013, 88, 519-552

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The microwave-to-flow paradigm: Translating high-temperature batch microwave chemistry to scalable continuous-flow processes

Glasnov, T. N.; Kappe, C. O.; Chem. Eur. J., 2011, 17, 11956-11968

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The recent advancement of hydrogenation technology and their implications for drug discovery research

Spadoni, C.; Jones, R.; Urge, L.; Darvas, F.; Chemistry Today, 2005, January/February, 36-39

The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches

Gordon, P. C.; Org. Biomol. Chem., 2018, 16, 180-196

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The role of flow in green chemistry and engineering

Newman, S. G.; Jensen, K. F.; Green Chem., 2013, 15, 1456-1472

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The role of water in catalytic biomass-based technologies to produce chemicals and fuels

Mika, L. T.; Csefalvay, E.; Horvath, I. T.; Catalysis Today, 2015, 247, 33-46

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The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

Baumann, M.; Baxendale, I. R.; Beilstein J. Org. Chem., 2015, 11, 1194-1219

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The synthesis of azabicyclic heterocycles

Darout, E.; Basak, A.; Tetrahedron Letters, 2010, 51, 2998-3001

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The titanium-mediated double reductive cleavage of cyclic sulfonamides for the synthesis of aryl pyrrolidines

Khalifa, A.; Evans, P.; J. Org. Chem., 2019, 84(5), 2969-2975

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The use of a continuous flow-reactor employing a mixed hydrogen–liquid flow stream for the efficient reduction of imines to amines

Saaby, S.; Knudsen, K. R.; Ladlow, M., Ley, S. V.; Chem. Commun., 2005, 23, 2909-2911

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The use of gases in flow synthesis

Mallia, C. J.; Baxendale, I. R.; Org. Process Res. Dev., 2016, 20(2), 327-360

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Thermochemiluminescence-Based Sensitive Probes: Synthesis and Photophysical Characterization of Acridine-Containing 1,2-Dioxetanes Focusing on Fluorophore Push-Pull Effects

Moroni, G. et al.; ChemPhotoChem, 2022, 6(1), e202100152

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Titanium nitride-nickel nanocomposite as heterogeneous catalyst for the hydrogenolysis of aryl ethers

Molinari, V.; Giordano, C.; Antonietti, M.; Esposito, D.; J. Am. Chem. Soc., 2014, 136(5), 1758-1761

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Tools for chemical synthesis in microsystems

Jensen, K. F.; Reizman, B. J.; Newman, S. G.; Lab. Chip, 2014, 14, 3206-3212

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Tools for efficient high-throughput synthesis

Chighine, A.; Sechi, G.; Bradley, M.; Drug Discovery Today, 2007, 12, 459-464

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Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2

Adams, D. R.; Tawati, S.; Berretta, G.; Rivas, P. L.; Baiget, J.; Jiang, Z.; Alsfouk, A.; MacKay, S. P.; Pyne, N.; Pyne, S.; J. Med. Chem., 2019, 62(7), 3658-3676

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Total chemical synthesis of PSMA-11: API for 68Ga-PSMA-11 used for prostate cancer diagnosis

Kumar, K. S. A. et al.; Eur. J. Med. Chem., 2021, 3, 100014

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Total syntheses of the dipyrrolobenzoquinone (+)-terreusinone enabled by an evaluation of 4-methylpent-1-yn-3-ols in the Larock indole synthesis

Wang, C.; Sperry, J.; Tetrahedron, 2013, 69(23), 4563-4577

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Total synthesis and biological evaluation of tubulysin analogues

Colombo, R.; Wang, Z.; Han, J.; Balachandran, R.; Daghestani, H. N.; Camarco, D. P.; Vogt, A.; Day, B. W.; Mendel, D.; Wipf, P.; J. Org. Chem., 2016, 81(21), 10302-10320

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Total synthesis of (±)-monomorine

Le, T. Q.; Oliver, R. M.; Arcari, J. T.; Mitton-Fry, M. J.; Tetrahedron Letters, 2012, 53(42), 5660-5662

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Total synthesis of (±)-taiwaniaquinol F and related taiwaniaquinoids

Kakde, B. N.; Kumari, P.; Bisai, A.; J. Org. Chem., 2015, 80(20), 9889-9899

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Total synthesis of aignopsanes, a class of sesquiterpenes: (+)‐Aignopsanoic acid A, (−)‐methyl aignopsanoate A, and (−)‐isoaignopsanoic A

Burki, C.; Bonjoch, J.; Bradshaw, B.; Villa, G.; Renaud, P.; Chem. Eur. J., 2015, 21(1), 395-401

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Total synthesis of the macrocyclic N-methyl enamides palmyrolide A and 2S-sanctolide A

Wadsworth, A. D.; Furkert, D. P.; Brimble, M. A.; J. Org. Chem., 2014, 79(22), 11179-11193

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Total synthesis, stereochemical assignment, and biological activity of chamuvarinin and structural analogues

Florence, G. J.; Morris, J. C.; Murray, R. G.; Vanga, R. R.; Osler, J. D.; Smith, T. K.; Chem. Eur. J., 2013, 19, 8309-8320

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Toward a continuous-flow synthesis of Boscalid®

Glasnov, T. N.; Kappe; C. O.; Adv. Synth. Catal., 2010, 352, 3089-3097

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Toward the synthesis of noroxymorphone via aerobic palladium-catalyzed continuous flow N-demethylation strategies

Gutmann, B.; Elsner, P.; Cox, D. P.; Weigl, U.; Roberge, D. M.; Kappe, C. O.; ACS Sustainable Chem. Eng., 2016, 4(11), 6048-6061

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Towards a continuous flow environment for lipase-catalyzed reactions

Itabaiana, I., Jr.; Soter de Mariz e Miranda, L.; de Souza, R. O. M. A.; Journal of Molecular Catalysis B: Enzymatic, 2013, 85-86, 1-9

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Towards industrial furfural conversion: Selectivity and stability of palladium and platinum catalysts under continuous flow regime

Ouyang, W.; Yepez, A.; Romero, A. A.; Luque, R.; Catalysis Today, 2018, 308, 32-37

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Towards the development of chromone-based MEK1/2 modulators

Redwan, I. N.; Dyrager, C.; Solano, C.; de Troconiz, G. F.; Voisin, L.; Bliman, D.; Meloche, S.; Grotli, M.; Eur. J. Med. Chem., 2014, 85, 127-138

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Transfer hydrogenation of levulinic acid under hydrothermal conditions catalyzed by sulfate as a temperature-switchable base

Kopetzki, D.; Antonietti, M.; Green Chem., 2010, 12, 656-660

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Transition-metal-catalyzed cyclopropanation of nonactivated alkenes in dibromomethane with triisobutylaluminium

Brunner, G.; Elmer, S.; Schroder, F.; Eur. J. Org. Chem., 2011, 4623-4633

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Translating high-temperature microwave chemistry to scalable continuous flow processes

Damm, M.; Glasnov, T. N.; Kappe, C. O.; Org. Process Res. Dev., 2010, 14(1), 215-224

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Treatments of lignocellulosic hydrolysates and continuous-flow hydrogenation of xylose to xylitol

Feher, A.; Feher, C.; Rozbach, M.; Racz, G.; Fekete, M.; Hegedus, L.; Barta, Z.; Chem. Eng. Technol., 2018, 41(3), 496-503

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Tunability and scalability of single-atom catalysts based on carbon nitride

Chen, Z.; Mitchell, S.; Krumeich, F.; Hauert, R.; Yakunin, S.; Kovalenko, M. V.; Perez-Ramirez, J.; ACS Sustainable. Chem. Eng., 2019, 7(5), 5223-5230

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Tuning nano-nickel selectivity with tin in flow hydrogenation of 6-methyl-5-hepten-2-one by surface organometallic chemistry modification

Zienkiewicz-Machnik, M.; Goszewska, I.; Srebowata, A.; Kubas, A.; Gizinski, D.; Slowik, G.; Matus, K.; Lisovytskiy, D.; Pisarek, M.; Sa, J.; Catalysis Today, 2018, 308, 38-44

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Tuning the Selectivity of the Hydrogenation/Hydrogenolysis of 5-Hydroxymethylfurfural under Batch Multiphase and Continuous-Flow Conditions

Rodriguez-Padron, D. et al.; ChemSusChem, 2022, 15(13), e202200503

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Two step continuous-flow synthesis of benzocaine

de S. Franca, A. et al.; J. Flow Chem., 2020, 10, 563-569

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Tyrosinases in organic chemistry: A versatile tool for the α‐arylation of β‐dicarbonyl compounds

Krug, R.; Schroder, D.; Gebauer, J.; Suljic, S.; Morimoto, Y.; Fujieda, N.; Itoh, S.; Pietruszka, J.; Eur. J. Org. Chem., 2018, 2018(15), 1789-1796

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Understanding flow chemistry for the production of active pharmaceutical ingredients

Luque, R. et al.; iScience, 2022, 25, 103892

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Unusual behavior in the reactivity of 5-substituted- 1H-tetrazoles in a resistively heated microreactor

Gutmann, B.; Glasnov, T. N.; Razzaq, T.; Goessler, W.; Roberge, D. M.; Kappe, C.O.; Beilstein J. Org. Chem., 2011, 7, 503-517

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Use of Immobilized Amine Transaminase from Vibrio fluvialis under Flow Conditions for the Synthesis of (S)-1-(5-Fluoropyrimidin-2-yl)-ethanamine

Semproli, R. et al.; ChemCatChem, 2020, 12(5), 1359-1367

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Use of Vinyl Sulfides in Fischer Indole Reactions

Pal, P. et al.; Synthesis, 2022, Accepted manuscript

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User friendly and flexible Kiliani reaction on ketoses using microreaction technology

Cukalovic, A.; Monbaliu, J-C., M.; Heynderickx, G. J.; Stevens, C. V.; J. Flow Chem., 2012, 2(2), 43-46

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Using chemical probes to investigate the sub-inhibitory effects of azithromycin

Glansdorp, F. G.; Spandl, R. J.; Swatton, J. E.; Loiseleur, O.; Welch, M.; Spring, D. R.; Org. Biomol. Chem., 2008, 6, 4120-4124

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Using continuous processes to increase production

Anderson, N. G.; Org. Process Res. Dev., 2012, 16(5), 852-869

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Using Oxygen as the Primary Oxidant in a Continuous Process: Application to the Development of an Efficient Route to AZD4635

Karlsson, S. et al.; Org. Process Res. Dev., 2022, 26(4), 1048-1053

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Valorization of humins-extracted 5-methoxymethylfurfural: Toward high added value furanics via continuous flow catalytic hydrogenation

Pfab, E.; Filiciotto, L.; Romero, A. A.; Luque, R.; Ind. Eng. Chem. Res., 2019, 58(35), 16065-16070

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Valorization of lignin waste from hydrothermal treatment of biomass

Chieffi, G.; Fechler, N.; Esposito, D.; RSC Adv., 2015, 5(78), 63691-63696

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Versatile dual hydrogenation-oxidation nanocatalysts for the aqueous transformation of biomass-derived platform molecules

Garcia-Suarez, E. J.; Balu, A. M.; Tristany, M.; Garcia, A. B.; Philippot, K.; Luque, R.; Green Chem., 2012, 14, 1434-1439

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Versatile low-loaded mechanochemically synthesized supported iron oxide nanoparticles for continuous flow alkylations

Balu, A. M.; Pineda, A.; Obermayer, D.; Romero, A. A., Kappe, C. O.; Luque, R.; RSC Adv., 2013, 3, 16292-16295

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Visible-light-mediated iodoperfluoroalkylation of alkenes in flow and its application to the synthesis of a key Fulvestrant intermediate

Rosso, C.; Williams, J. D.; Filippini, G.; Prato, M.; Kappe, C. O.; Org. Lett., 2019, 21(13), 5341-5345

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Visually following the hydrogenation of curcumin to tetrahydrocurcumin in a natural product experiment that enhances student understanding of NMR spectroscopy

Wagner, C. E.; Marshall, P. A.; Cahill, T. M.; Mohamed, Z.; J. Chem. Educ., 2013, 90(7), 930-933

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VUT-MK142: a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes

Koley, M.; Mike, A. K.; Heher, P.; Koenig, X.; Schon, M.; Schnurch, M.; Hilber, K.; Weitzer, G.; Mihovilovic, M. D.; Med. Chem. Commun., 2013, 4, 1189-1195

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Yolk‐shell‐mesostructured silica‐supported dual molecular catalyst for enantioselective tandem reactions

Wu, L.; Li, Y.; Meng, J.; Jin, R.; Lin, J.; Liu, G.; ChemPlusChem, 2018, 83(9), 861-867

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