Publications

1,3,5-Trisubstituted pyrazoles as potent negative allosteric modulators of the mGlu2/3 receptors

Van Gool, M.; Alonso De Diego, S. A.; Delgado, O.; Trabanco, A. A.; Jourdan, F.; Macdonald, G. J.; Somers, M.; Ver Donck, L.; ChemMedChem, 2017, 12(12), 905-912

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1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activity

Abdel-Hamid, M. K.; Macgregor, K. A.; Odell, L. R.; Chau, N.; Mariana, A.; Whiting, A.; Robinson, P. J.; McCluskey, A.; Org. Biomol. Chem., 2015, 13, 8016-8028

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2,7-Pyrrolo[2,1-f][1,2,4]triazines as JAK2 inhibitors: modification of target structure to minimize reactive metabolite formation

Weinberg, L. R.; Albom, M. S.; Angeles, T. S.; Breslin, H. J.; Gingrich, D. E.; Huang, Z.; Lisko, J. G.; Mason, J. L.; Milkiewicz, K. L.; Thieu, T. V.; Underiner, T.L .; Wells, G. J.; Wells-Knecht, K. J.; Dorsey, B. D.; Bioorg. Med. Chem. Lett., 2011, 21(4), 7325-7330

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3‐Aminoazetidin‐2‐one derivatives as N‐acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration

Fiasella, A.; Nuzzi, A.; Summa, M.; Armirotti, A.; Tarozzo, G.; Tarzia, G.; Mor, M.; Bertozzi, F.; Bandiera, T.; Piomelli, D.; ChemMedChem, 2014, 9(7), 1602-1614

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3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Ferrins, L.; Rahmani, R.; Sykes, M. L.; Jones, A. J.; Avery, V. M.; Teston, E.; Almohaywi, B.; Yin, J.; Smith, J.; Hyland, C.; White, K. L.; Ryan, E.; Campbell, M.; Charman, S. A.; Kaiser, M.; Baell, J. B.; Eur. J. Med. Chem., 2013, 66, 450-465

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3-Substituted xanthines as promising candidates for quadruplex formation: computational, synthetic and analytical studies

Szolomajer, J.; Paragi, G.; Batta, Gy.; Guerra, F. C.; Bickelhaupt, F. M.; Kele, Z.; Padar, P.; Kupihar, Z.; Kovacs, L.; New Journal of Chemistry, 2011, 35, 476-482

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4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as high-affinity non-imidazole histamine H3 receptor agonists with in vivo central nervous system activity

Wagner, G.; Mocking, T.; Arimont, M.; Provensi, G.; Rani, B.; Silva-Marques, B.; Latacz, G.; Da Costa Pereira, D.; Karatzidou, K.; Vischer, H. F.; Wijtmans, M.; Kiec-Kononowicz, K.; De Esch, I. J. P.; Leurs, R.; J. Med. Chem., 2019, accepted manuscript

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4′-C-methyl-2-deoxyadenosine and 4-C-ethyl-2-deoxyadenosine inhibit HIV-1 replication

Vu, B. C.; Boyer, P. L.; Siddiqui, M. A.; Marquez, V. E.; Hughes, S. H.; Antimicrobial Agents and Chemotheraphy, 2011, 55(5), 2379-2389

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4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-based P2X7 receptor antagonists: optimization of pharmacokinetic properties leading to the identification of a clinical candidate

Letavic, M. A.; Savall, B. M.; Allison, B. D.; Aluisio, L.; Andres, J. I.; De Angelis, M.; Ao, H.; Beauchamp, D. A.; Bonaventure, P.; Bryant, S.; Carruthers, N. I.; Ceusters, M.; Coe, K. J.; Dvorak, C. A.; Fraser, I. C.; Gelin, C. F.; Koudriakova, T.; Liang, J.; Lord, B.; Lovenberg, T. W.; Otieno, M. A.; Schoetens, F.; Swanson, D. M.; Wang, Q.; Wickenden, A. D.; Bhattacharya, A.; J. Med. Chem., 2017, 60(11), 4559-4572

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α-1,4-Galactosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins

Simerska, P.; Christie, M. P.; Goodwin, D.; Jen, F. E-C.; Jennings, M. P.; Toth, I.; Journal of Molecular Catalysis B: Enzymatic, 2013, 97, 196-202

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A benchtop continuous flow reactor: a solution to the hazards posed by gas cylinder based hydrogenation

Dorman, G.; Kocsis, L.; Jones, R.; Darvas, F.; Journal of Chemical Health and Safety, 2013, 20(4), 3-8

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A comparative assessment study of known small-molecule Keap1−Nrf2 protein–protein interaction inhibitors: Chemical synthesis, binding properties, and cellular activity

Tran, K. T.; Pallesen, J. S.; Solbak, S. M. O.; Narayanan, D.; Baig, A.; Zang, J.; Aguayo-Orozco, A.; Carmona, R. M. C.; Garcia, A. D.; Bach, A.; J. Med. Chem., 2019, 62(17), 8028-8052

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A comparative study of supported monometallic catalysts in the liquid-phase hydrogenation of furfural: batch vs. continuous flow

Wang, Y.; Prinsen, P.; Triantafyllidis, K. S.; Karakoulia, S. A.; Trikalitis, P. N.; Yepez, A.; Len, C.; Luque, R.; ACS Sustainable Chem. Eng., 2018, 6(8), 9831-9844

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A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

Baumann, M.; Baxendale, I. R.; Deplante, F.; Beilstein J. Org. Chem., 2017, 13, 2549-2560

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A concise stereoselective synthesis of pterosin B

Dexter, H. R.; Allen, E.; Williams, D. M.; Tetrahedron Letters, 2018, 59(49), 4323-4325

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A continuous-flow approach to palladium-catalyzed alkoxycarbonylation reactions

Kelly, C. B.; Lee, C. (X.); Mercadante, M. A.; Leadbeater N. E.; Org. Process Res. Dev., 2011, 15(3), 717-720

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A continuous-flow microwave reactor for conducting high-temperature and high-pressure chemical reactions

Sauks, J. M.; Mallik, D.; Lawryshyn, Y.; Bender, T.; Organ, M.; Org. Process Res. Dev., 2014, 18(11), 1310-1314

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A continuous flow process for the green and sustainable production of N-alkyl imidazoles

Fekete, M.; Kocsis L.; Dorman, G.; Jones, R. V.; Darvas, F.; Green Processing and Synthesis, 2016, 5(3), 239-246

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A continuous flow process for the production of 2,5-dimethylfuran from fructose using (non-noble metal based) heterogeneous catalysis

Braun, M.; Antonietti, M.; Green Chemistry, 2017, 19, 3813-3819

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A continuous flow strategy for the facile synthesis and elaboration of semi-saturated heterobicyclic fragments

Luise, N.; Wyatt, E. W.; Tarver, G. J.; Wyatt, P. G.; Eur. J. Org. Chem., 2018, 2019(6), 1341-1349

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A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

Viviano, M.; Milite, C.; Rescigno, D.; Castellano, S.; Sbardella, G.; RSC Adv., 2015, 5, 1268-1273

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A continuous flow system for asymmetric hydrogenation using supported chiral catalysts

Madarasz, J.; Farkas, G.; Balogh, S.; Szollosy, A.; Kovacs, J.; Darvas, F.; Urge, L.; Bakos, J.; J. Flow Chem., 2011, 1(2), 62-67

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A continuous-flow, two-step, metal-free process for the synthesis of differently substituted chiral 1,2-diamino derivatives

Pirola, M.; Compostella, M. E.; Raimondi, L.; Puglisi, A.; Benaglia, M.; Synthesis, 2018, 50, 1430-1438

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A continuous process for glyoxal valorisation using tailored Lewis-acid zeolite catalysts

Dapsens, P. Y.; Mondelli, C.; Kusema, B. T.; Verel, R., Perez-Ramirez, J.; Green Chemistry, 2014, 16, 1176-1186

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A facile, protic ionic liquid route to N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides and N-substituted 3-oxoisoindoline-4-carboxylic acids

Gordon, C. P.; Byrne, N.; McCluskey, A.; Green Chem., 2010, 12, 1000-1006

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A flexible approach to 6,5-benzannulated spiroketals

Wilson, Z. E.; Hubert, J. G.; Brimble, M. A.; Eur. J. Org. Chem., 2011, 2011(20-21), 3938-3945

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A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core

Hay, D. A.; Adam, F. M.; Bish, G.; Calo, F.; Dixon, R.; Fray, M. J.; Hitchin, J.; Jones, P.; Paradowski, M.; Parsons, G. C.; Proctor, K. J. W.; Pryde, D. C.; Smith, N. N.; Tran, T. D.; Tetrahedron Letters, 2011, 52(44), 5728-5732

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A flow-based synthesis of telmisartan

Martin, A. D.; Siamaki, A. R.; Belecki, K.; Gupton, B. F.; J. Flow Chem., 2015, 5(3), 145-147

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A flow chemistry route to 2-phenyl-3-(1H-pyrrol-2-yl)propan-1-amines

Tarleton, M.; McCluskey, A.; Tetrahedron Letters, 2011, 52(14), 1583-1586

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A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.; Chem. Commun., 2006, 2566-2568

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A flow process using microreactors for the preparation of a quinolone derivative as a potent 5HT1B antagonist

Qian, Z.; Baxendale, I. R.; Ley, S. V.; Synlett, 2010, 4, 505-508

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A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K.; Chem. Commun., 2006, 4835-4837

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A gram-scale batch and flow total synthesis of perhydrohistrionicotoxin

Brasholz, M.; Macdonald, J. M.; Saubern, S.; Ryan, J. H.; Holmes, A. B.; Chem. Eur. J., 2010, 16(37), 11471-11480

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A method to identify best available technologies (BAT) for hydrogenation reactors in the pharmaceutical industry

Van Le Doan, T.; Stavarek, P.; de Bellefon, C.; J. Flow Chem., 2012, 2(3), 77-82

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A modular synthesis of teraryl‐based α‐helix mimetics, part 2: Synthesis of 5‐pyridine boronic acid pinacol ester building blocks with amino acid side chains in 3‐position

Peters, M.; Trobe, M.; Breinbauer, R.; Chem. Eur. J., 2013, 19(7), 2450-2456

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A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands

Petersen, T. P.; Ritzen, A.; Ulven, T.; Org. Lett., 2009, 11(22), 5134-5137

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A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells

Kim, J.; Moon, S. H.; Kim, B. T.; Chae, C. H.; Lee, J. Y.; Kim, S. H.; PLoS One, 2014, 9(10), e110180

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A novel method for high-throughput reduction of compounds through automated sequential injection into a continuous-flow microfluidic reactor

Jones, R.; Godorhazy, L.; Szalay, D.; Gerencser, J.; Dorman, G.; Urge, L.; Darvas, F.; QSAR Comb. Sci., 2005, 24(6), 722-727

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A practical and benign synthesis of amines through Pd@mpg-C3N4 catalyzed reduction of nitriles

Li, Y.; Gong, Y.; Xu, X.; Zhang, P.; Li, H.; Wang, Y.; Catalysis Communications, 2012, 28, 9-12

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A remote-controlled adaptive medchem lab: an innovative approach to enable drug discovery in the 21st Century

Godfrey, A. G.; Masquelin, T.; Hemmerle, H.; Drug Discovery Today, 2013, 18(17-18), 795-802

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A safe and selective method for reduction of 2-nitrophenylacetic acid systems to N-aryl hydroxamic acids using continuous flow hydrogenation

Ichire, O.; Jans, P.; Parfenov, G.; Dounay, A. B.; Tetrahedron Letters, 2017, 58(6), 582-585

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A scalable two-step continuous flow synthesis of nabumetone and related 4-aryl-2-butanones

Viviano, M.; Glasnov, T. N.; Reichard, B.; Tekautz, B.; Kappe, C. O.; Org. Process Res. Dev., 2011, 15, 858-870

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A simple chemical model for clathrate hydrate inhibition by polyvinylcaprolactam

Davenport, J. R.; Musa, O. M.; Paterson, M. J.; Piepenbrock, M. O. M.; Fucke, K.; Steed, J. W.; Chem. Commun., 2011, 47, 9891-9893

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A simple, efficient, and selective deuteration via a flow chemistry approach

Mandity, I. M.; Martinek, T. A.; Darvas, F.; Fulop, F.; Tetrahedron Letters, 2009, 50, 4372-4374

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A stereoselective, catalytic strategy for the in-flow synthesis of advanced precursors of rasagiline and tamsulosin

Brenna, D.; Pirola, M.; Raimondi, L.; Burke, A. J.; Benaglia, M.; Bioorg. Med. Chem., 2017, 25(23), 6242-6247

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A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors

Gordon, C. P.; Dalton, N.; Vandegraaff N.; Deadman, J.; Rhodes, D. I.; Coates, J. A.; Pyne, S. G.; Griffith, R.; Bremner, J. B.; Keller, P. A.; Tetrahedron, 2018, 74(12), 1253-1268

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A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir

Dalla-Vechia, L.; Reichart, B.; Glasnov, T. N.; Miranda, L. S. M.; Kappe, C. O.; de Souza, R. O. M. A.; Org. Biomol. Chem., 2013, 11, 6806-6813

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A ‘turn-on’ fluorescence glycosyl dithiocarbamate probe for selective fluoride sensing in aqueous medium

Das, R.; Mishra, B.; Mukhopadhyay, B.; Synlett, 2018, 29(15), 2001-2005

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A two‐step continuous‐flow synthesis of N‐(2‐aminoethyl)acylamides through ring‐opening/hydrogenation of oxazolines

Gutmann, B.; Roduit, J. P.; Roberge, D.; Kappe, C. O.; Chem. Eur. J., 2011, 17, 13146-13150

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A versatile biobased continuous flow strategy for the production of 3-butene-1,2-diol and vinyl ethylene carbonate from erythritol

Tshibalonza, N. N.; Gerardy, R.; Alsafra, Z.; Eppe, G.; Monbaliu, J-C. M.; Green Chem., 2018, 20, 5147-5157

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A versatile de novo synthesis of legionaminic acid and 4-epi-legionaminic acid starting from D-serine

Gintner, M.; Yoneda, Y.; Schmölzer, C.; Denner, C.; Kahlig, H.; Schmid, W.; Carbohydrate Research, 2019, 474, 34-42

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A Warburg effect targeting vector designed to increase the uptake of compounds by cancer cells demonstrates glucose and hypoxia dependent uptake

Glenister, A.; Simone, M. I.; Hambley, T. W.; PLos One, 2019, online article

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Access to optically active 3‐aminopiperidines by ring expansion of prolinols: Thermodynamic versus kinetic control

Cochi, A. ; Pardo, D. G.; Cossy, J.; Eur. J. Org. Chem., 2012, 2012(10), 2023-2040

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Accessing novel process windows in a high‐temperature/pressure capillary flow reactor

Razzaq, T.; Glasnov, T. N.; Kappe, C. O.; Chem. Eng. Technol., 2009, 32(11), 1702-1716

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Activity of continuous flow synthesized Pd-based nanocatalysts in the flow hydroconversion of furfural

Garcia-Olmo, A. J.; Yepez, A.; Balu, A. M.; Prinsen, P.; Garcia, A.; Maziere, A.; Len, C.; Luque, R.; Tetrahedrom, 2017, 73(38), 5599-5604

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Acylguanidine beta secretase 1 inhibitors: a combined experimental and free energy perturbation study

Keranen, H.; Perez-Benito, L.; Ciordia, M.; Delgado, F.; Steinbrecher, T. B.; Oehlrich, D.; van Vlijmen, H. W. T.; Trabanco, A. A.; Tresadern, G.; J. Chem. Theory Comput., 2017, 13, 1439-1453

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Adaptive and automated system-optimization for heterogeneous flow-hydrogenation reactions

Fabry, D. C.; Heddrich, S.; Sugiono, E.; Liauw, M. A.; Rueping, M.; React. Chem. Eng., 2019, 4, 1486-1491

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Additive manufacturing technologies: 3D printing in organic synthesis

Rossi, S.; Puglisi, A.; Banglia, M.; ChemCatChem, 2018, 10(7), 1512-1525

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Aerobic flow oxidation of alcohols in water catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

Osako, T.; Torii, K.; Uozumi, Y.; RSC Adv., 2015, 5, 2647-2654

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Alkyne–azide cycloadditions with copper powder in a high‐pressure continuous‐flow reactor: High‐temperature conditions versus the role of additives

Otvos, S. B.; Mandity, I. M.; Kiss, L.; Fulop, F.; Chem. Asian J., 2013, 8(4), 800-808

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Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitor

Ponomarev, K. Yu.; Suslov, E. V.; Zakharenko, A. L.; Zakharova, O. D.; Rogachev, A. D.; Korchagina, D. V.; Zafar, A.; Reynisson, J.; Nefedov, A. A.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I.; Bioorg. Chem., 2018, 76, 392-399

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Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization

Whelligan, D. K.; Solanki, S.; Taylor, D.; Thomson, D. W.; Cheung, K. J.; Boxall, K.; Mas-Droux, C.; Barillari, C.; Burns, S.; Grummitt, C. G.; Collins, I.; van Montfort, E. L. M.; Aherne, G. W.; Bayliss, R.; Hoelder, S.; J. Med. Chem., 2010, 53, 7682-7698

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An alternative route for fondaparinux sodium synthesis via selective hydrogenations and sulfation of appropriate pentasaccharides

Manikowski, A.; Koziol, A.; Czajkowska-Wojciechowska, E.; Carbohydrate Research, 2012, 361, 155-161

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An efficient and more sustainable one-step continuous-flow multicomponent synthesis approach to chromene derivatives

Vaddula, B. R.; Yalla, S.; Gonzalez, M. A.; J. Flow Chem., 2015, 5(3), 172-177

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An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process

Sedelmeier, J.; Ley, S. V.; Baxendale, I. R.; Green Chem., 2009, 11, 683-685

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An efficient continuous flow approach to furnish furan-based biaryls

Trinh, T. N.; Hizartzidis, L.; Lin, A. J. S.; Harman, D. G.; McCluskey, A.; Gordon, C. P.; Org. Biomol. Chem., 2014, 12, 9562-9571

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An imidazolium-based organopalladium-functionalized organic–inorganic hybrid silica promotes one-pot tandem Suzuki cross coupling–reduction of haloacetophenones and arylboronic acids

Zhang, D.; Cheng, T.; Liu, G.; Applied Catal. B: Environmental, 2015, 174-175, 344-349

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An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor

Russell, C.; Lin, A. J. S.; Hains, P.; Simone, M. I.; Robinson, P. J.; McCluskey, A.; RSC Adv., 2015, 5, 93433-93437

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An orally bioavailable, indole-3-glyoxylamide based series of tubulin polymerization inhibitors showing tumor growth inhibition in a mouse xenograft model of head and neck cancer

Colley, H. E.; Muthana, M.; Danson, J. S.; Jackson, L. V.; Brett, M. L.; Harrison, J.; Coole, S. F.; Mason, D. P.; Jennings, L. R.; Wong, M.; Tulasi, V.; Noraman, D.; Lockey, P. M.; Williams, L.; Dossetter, A. G.; Griffen, E. J.; Thompson, M. J.; J. Med. Chem., 2015, 58(23), 9309-9333

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Application of continuous flow and alternative energy devices for 5-hydroxymethylfurfural production

Schon, M.; Schnurch, M.; Mihovilovic, M. D.; Mol. Divers., 2011, 15, 639-643

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Application of deuterated THENA for assigning the absolute configuration of chiral secondary alcohols

Soponpong, J.; Dolsophon, K.; Thongpanchang, C.; Linden, A.; Thongpanchang, T.; Tetrahedron Letters, 2019, 60(6), 497-500

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Application of factorial design of experiments for the continuous hydrogenation of enriched castor oil methyl esters

Neeharika, T. S. V. R.; Rani, K. N. P.; Rao, K. V. S. A.; Kumar, T. P.; Prasad, R. B. N.; Bulletin of Chemical Reaction Engineering & Catalysis, 2013, 8(2), 154-159

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Application of metal‐based reagents and catalysts in microstructured flow devices

Chinnusamy, T.; Yudha S. S.; Hager, M.; Kreitmeier, P.; Reisen, O.; ChemSusChem, 2012, 5(2), 247-255

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Applying flow chemistry: Methods, materials, and multistep synthesis

McQuade, D. T.; Seeberger, P. H.; J. Org. Chem., 2013, 78(13), 6384-6389

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Approaches to pyranuronic β-sugar amino acid building blocks of peptidosaccharide foldamers

Goldschmidt-Goz, V.; Pinter, I.; Harmat, V.; Perczel, A.; Eur. J. Org. Chem., 2018, 3, 355-361

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Aqueous flow hydroxycarbonylation of aryl halides catalyzed by an amphiphilic polymer-supported palladium–diphenylphosphine catalyst

Osako, T.; Kaiser, R.; Torii, K.; Uozumi, Y.; Synlett, 2019, 30, 961-966

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Assignment of vibrational circular dichroism cross‐referenced electronic circular dichroism spectra of flexible foldamer building blocks: Towards assigning pure chiroptical properties of foldamers

Farkas, V.; Nagy, A.; Menyhard, D. K.; Perczel, A.; Chem. Eur. J., 2019, 25(65), 14890-14900

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Asymmetric aldol reaction in a continuous-flow reactor catalyzed by a highly reusable heterogeneous peptide

Otvos, S. B.; Mandity, I. M.; Fulop, F.; J. Cat., 2012, 295, 179-185

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Asymmetric hydrogenation of C=C double bonds using Rh-complex under homogeneous, heterogeneous and continuous mode conditions

Balogh S.; Farkas, G.; Madarasz, J.; Szollosy, A.; Kovacs, J.; Darvas, F.; Urge L.; Bakos, J.; Green Chem., 2012, 14, 1146-1151

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Asymmetric Mannich reaction of dicarbonyl compounds with α-amido sulfones catalyzed by cinchona alkaloids and synthesis of chiral dihydropyrimidones

Lou, S.; Dai, P.; Schaus, S. E.; J. Org. Chem., 2007, 72, 9998-10008

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Asymmetric organocatalytic Michael addition–cyclisation cascade of cyclopentane-1,2-dione with alkylidene malononitriles

Silm, E.; Kaabel, S.; Jarving, I.; Kanger, T.; Synthesis, 2019, 51, 4198-4204

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Atomic Cu on nanodiamond-based sp2/sp3 hybrid nanostructures for selective hydrogenation of phenylacetylene

Sun, Y.; Luo, B.; Xu, S.; Guo, W.; Huang, X.; Shao, L.; Chemical Physics Letters, 2019, 723, 39-43

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Automated technology for performing flow chemistry at elevated temperature and pressure

Kovacs, I.; Jones, R. V.; Niesz, K.; Csajagi, Cs.; Borcsek, B.; Darvas, F.; Urge, L.; JALA, 2007, 12, 284-290

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Aziridine ring opening for the synthesis of sphingolipid analogues: Inhibitors of sphingolipid-metabolizing enzymes

Alcaide, A.; Llebaria, A.; J. Org. Chem., 2014, 79(7), 2993-3029

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Batch and flow hydrotreatment of water contaminated by trichloroethylene on active carbon supported nickel catalysts

Kaminska, I. I.; Kowalewski, E.; Lisovytskiy, D.; Blachucki, W.; Rarog-Pilecka, W.; Lomot, D.; Srebowata, A.; Applied Catalysis A: General, 2019, 582, 117110

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Batch versus continuous flow performance of supported mono‐ and bimetallic nickel catalysts for catalytic transfer hydrogenation of furfural in isopropanol

Wang, Y.; Prinsen, P.; Triantafyllidis, K. S.; Karakoulia, S. A.; Yepez, A.; Len, C.; Luque, R.; ChemCatChem, 2018, 10(16), 3459-3468

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Benchmarking immobilized di- and triarylphosphine palladium catalysts for continuous-flow cross-coupling reactions: Efficiency, durability, and metal leaching studies

Greco, R.; Goessler, W.; Cantillo, D.; Kappe, C. O.; ACS Catal., 2015, 5, 1303-1312

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Benign-by-design orange peel-templated nanocatalysts for continuous flow conversion of levulinic acid to N-heterocycles

Rodriguez-Padron, D.; Puente-Santiago, A. R.; Balu, A. M.; Romero, A. A.; Munoz-Batista, M. J.; Luque, R.; ACS Sustainable Chem. Eng., 2018, 6(12), 16637-16644

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Benzo[d]imidazole transient receptor potential vanilloid 1 antagonists for the treatment of pain: Discovery of trans-2-(2-{2-[2-(4-trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

Parsons, W. H.; Calvo, R. R.; Cheung, W.; Lee, Y. K.; Patel, S.; Liu, J.; Youngman, M. A.; Dax, S. L.; Stone, D.; Qin, N.; Hutchinson, T.; Lubin, M. L.; Zhang, S. P.; Finley, M.; Liu, Y.; Brandt, M. R.; Flores, C. M.; Player, M. R.; J. Med. Chem., 2015, 58(9), 3859-3874

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Benzoxazinone synthesis via Passerini–Smiles couplings

Martinand-Lurin, E.; El Kaim, L.; Grimaud, L.; Tetrahedron Letters, 2014, 55(37), 5144-5146

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Benzoxazolone carboxamides as potent acid ceramidase inhibitors: Synthesis and structure–activity relationship (SAR) studies

Bach, A.; Pizzirani, D.; Realini, N.; Vozella, V.; Russo, D.; Penna, I.; Melzig, L.; Scarpelli, R.; Piomelli, D.; J. Med. Chem., 2015, 58(23), 9258-9272

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Beyond the use of modifiers in selective alkyne hydrogenation: silver and gold nanocatalysts in flow mode for sustainable alkene production

Vile, G.; Perez-Ramirez, J.; Nanoscale, 2014, 6, 13476-13482

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Bicyclic naphthenic acids in oil sands process water: Identification by comprehensive multidimensional gas chromatography–mass spectrometry

Wilde, M. J.; West, C. E.; Scarlett, A. G.; Jones, D.; Frank, R. A.; Hewitt, L. M.; Rowland, S. J.; Journal of Chromatography A, 2015, 1378, 74-87

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Bis(diethylamino)(pentafluorophenyl)phosphane – a push–pull phosphane available for coordination

Orthaber, A.; Fuchs, M.; Belaj, F.; Rechberger, G. N.; Kappe, C. O.; Pietschnig, R.; Eur. J. Inorg. Chem., 2011, 2588-2596

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Building β-peptide H10/12 foldamer helices with six-membered cyclic side-chains: Fine-tuning of folding and self-assembly

Mandity, M. I.; Fulop, L.; Vass, E.; Toth; G. K.; Martinek, T. A.; Fulop, F.; Organic Letters, 2010, 12(23), 5584-5587

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C-3 epimers of sugar amino acids as foldameric building blocks: improved synthesis, useful derivatives, coupling strategies

Nagy, A.; Csordas, B.; Zsoldos-Mady, V.; Pinter, I.; Farkas, V.; Perczel, A.; Amino acids, 2017, 49(2), 223-240

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Can two‐dimensional gas chromatography/mass spectrometric identification of bicyclic aromatic acids in petroleum fractions help to reveal further details of aromatic hydrocarbon biotransformation pathways?

West, C. E.; Pureveen, J.; Scarlett, A. G.; Lengger, S. K.; Wilde, M. J.; Korndorffer, F.; Tegelaar, E. W.; Rowland, S. J.; Rapid Commun. Mass Spectrom., 2014, 28(9), 1023-1032

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Carbonylation in microflow: close encounters of CO and reactive species

Fukuyama, T.; Totoki, T.; Ryu, I.; Green Chemistry, 2014, 16, 2042-2050

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Catalysis in flow: Au-catalysed alkylation of amines by alcohols

Zotova, N.; Robert, F. J.; Kelsall, G. H.; Jessiman, A. S.; Hellgardt, K.; Hii, K. K.; Gree Chem., 2012, 14, 226-232

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Catalysis in flow: the practical and selective aerobic oxidation of alcohols to aldehydes and ketones

Zotova, N.; Hellgardt, K.; Kelsall, G. H.; Jessiman, A. S.; Hii, K. K.; Green Chem., 2010, 12, 2157-2163

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Catalytic asymmetric crotylation of aldehydes: Application in total synthesis of (−)‐elisabethadione

O’Hora, P. S.; Incerti‐Pradillos, C. A.; Kabeshov, M. A.; Shipilovskikh, S. A.; Rubtsov, A. E.; Elsegood, M. R. J; Malkov, A. V.; Chem. Eur. J., 2015, 21(12), 4551-4555

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Catalytic epoxidation of cyclohexene with tert-butylhydroperoxide using an immobilized molybdenum catalyst

Morales-delaRosa, S.; Campos-Martin, J. M.; Terreros, P.; Fierro, J. L. G.; Topics in Catalysis, 2015, 58, 325-333

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Catalytic hydrogenolysis of substituted diaryl ethers by using ruthenium nanoparticles on an acidic supported ionic liquid phase (Ru@SILP-SO3H)

Rengshausen, S.; Etscheidt, F.; Großkurth, J.; Luska, K. L.; Bordet, A.; Leitner, W.; Synlett, 2019, 30(4), 405-412

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Catalytic oxidation of aqueous bioethanol: an efficient upgrade from batch to flow

Mostrou, S.; Sipocz, T.; Nagl, A.; Fodi, B.; Darvas, F.; Fottinger, K.; van Bokhoven, J. A.; React. Chem. Eng., 2018, 3, 781-789

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Catalytically sustainable, palladium-decorated graphene oxide monoliths for synthesis in flow

Ghobadi, S.; Burkholder, M. B.; Smith, S. E.; Gupton, B. F.; Castano, C. E.; Chem. Eng. J., 2020, 381, 122598

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Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

Gallagher, C. M.; Garri, C.; Cain, E. L.; Ang, K. K. H.; Wilson, C. G.; Chen, S.; Hearn, B. R.; Jaishankar, P.; Aranda-Diaz, A.; Arkin, M. R.; Renslo, A. R.; Walter, P.; eLife, 2016, 5, e:11878

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Characterization of dispersion effects on reaction optimization and scale-up for a packed bed flow hydrogenation reactor

Eschelbach, J. W.; Wernick, D.; Bryan, M. C.; Doherty, E. M.; Aust. J. Chem., 2013, 66, 165-171

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Chemical and bacterial reduction of azo-probes: monitoring a conformational change using fluorescence spectroscopy

Rattray, N. J. W.; Zalloum, W. A.; Mansell, D.; Latimer, J.; Jaffar, M.; Bichenkova, E. V.; Freeman, S.; Tetrahedron, 2013, 69, 2758-2766

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Chemical assembly systems: Layered control for divergent, continuous, multistep syntheses of active pharmaceutical ingredients

Ghislieri, D.; Gilmore, K.; Seeberger, P. H.; Angew. Chem. Int. Ed., 2014, 54(2), 678-682

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Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Rossetti, I.; Compagnoni, M.; Chemical Engineering Journal, 2016, 296, 56-70

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Chemical synthesis of a tetrasaccharide related to the exocellular polysaccharide from Rhodococcus sp. RHA1

Budhadev, D.; Mukhopadhyay, B.; Carbohydrate Research, 2014, 394, 26-31

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Chemical synthesis of the 4-amino-4,6-dideoxy-d-glucose containing pentasaccharide repeating unit of the O-specific polysaccharide from Aeromonas hydrophila strain K691 in the form of its 2-aminoethyl glycoside

Adak, A.; Mukhopadhyay, B.; Carbohydrate Research, 2019, 476, 1-7

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Chemical synthesis of the pentasaccharide related to the repeating unit of the O-Antigen from Salmonella enterica O4

Das, R.; Mukhopadhyay, B.; Journal of Carbohydrate Chemistry, 2015, 34(5), 247-262

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Chemical synthesis of the pentasaccharide repeating unit of the O-specific polysaccharide from Escherichia coli O132 in the form of its 2-aminoethyl glycoside

Pal, D.; Mukhopadhyay, B.; Beilstein J. Org. Chem., 2019, 15, 2563-2568

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Chemistry of 3-carbonyl-2-methyl-4-oxo-4H-1-benzopyrans

Ghosh, C. K.; Chakraborty, A.; ARKIVOC, 2016, 2016(1), 111-149

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Chemistry of pyrrolizidine alkaloids revisited – semi-synthetic microwave and continuous-flow approaches toward Crotalaria-alkaloids

Martineza, S. T.; Pinto, A. C.; Glasnov, T.; Kappe, C. O.; Tetrahedron Letters, 2014, 55(30), 4181-4184

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Chemo-enzymatic synthesis of 13C labeled complex N-glycans as internal standards for the absolute glycan quantification by mass spectrometry

Echeverria, B.; Etxebarria, J.; Ruiz, N.; Hernandez, A.; Calvo, J.; Haberger, M.; Reusch, D.; Reichardt, N-C.; Analytical Chemistry, 2015, 87(22), 11460-11467

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Chemoselective flow hydrogenation approaches to diversify the cytotoxic tetrahydroepoxyisoindole carboxamide scaffold

Spare, L. K.; Harman, D. G.; Aldrich-Wright, J. R.; Nguyen, T. V.; Gordon, C. P.; Adv. Synth. Catal., 2018, 360(6), 1209-1217

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Chemoselective flow hydrogenation approaches to isoindole-7-carboxylic acids and 7-oxa-bicyclio[2.2.1]heptanes

Hizartzidis, L.; Tarleton, M.; Gordon, C. P.; McCluskey, A.; RSC Adv., 2014, 4, 9709-9722

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Chiral auxiliary recycling in continuous flow: automated recovery and reuse of Oppolzer’s sultam

Sullivan, R. J.; Newman, S. G.; Chemical Science, 2018, 9, 2130-2134

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Cobalt-doped magnesium fluoride as a support for platinum catalysts: The correlation of surface acidity with hydrogenation activity

Pietrowski, M.; Zieliński, M.; Alwina, E.; Gulaczyk, I.; Przekop, R. E.; Wojciechowska, M.; J. Cat., 2019, 378, 298-311

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Combining enabling techniques in organic synthesis: continuous flow process with heterogenized catalysts

Kirschning, A.; Solodenko, W.; Mennecke, K.; Chem. Eur. J., 2006, 12(23), 5972-5990

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Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling

Baer, S.; Nigro, J.; Madej, M. P.; Nisbet, R. M.; Suryadinata, R.; Coia, G.; Hong, L. P. T.; Adams, T. E.; Williams, C. C.; Nuttall, S. D.; Org. Biomol. Chem., 2014, 12, 2675-2685

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Concise chemical synthesis of the pentasaccharide repeating unit of the O-antigen from Escherichia albertii O2

Bera, M.; Adak, A.; Mukhopadhyay, B.; Carbohydrate Research, 2019, 485, 107817

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Concise synthesis of a tetra- and a trisaccharide related to the repeating unit of the O-antigen from Providencia rustigianii O34 in the form of their p-methoxyphenyl glycosides

Verma, P. R.; Mukhopadhyay, B.; RSC Adv., 2013, 3, 201-207

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Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxidation

Chassagne, P.; Raibaut, L.; Guerreiro, C.; Mulard, L. A.; Tetrahedron, 2013, 69(48), 10337-10350

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Concise synthesis of the trisaccharide repeating unit of the O-polysaccharide from Aeromonas hydrophila A19 (O:14)

Pal, K. B.; Mukhopadhyay, B.; Carbohydrate Research, 2013, 379, 26-29

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Concise synthesis of vesnarinone and its analogues by using Pd‐catalyzed C–N bond‐forming reactions

See, Y. Y.; Dang, T. T.; Chen, A.; Seayad, A. M.; Eur. J. Org. Chem., 2014, 7405-7412

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Construction and validation of an automated flow hydrogenation instrument for application in high-throughput organic chemistry

Clapham, B.; Wilson, N. S.; Michmerhuizen, M. J.; Blanchard, D. P.; Dingle, D. M.; Nemcek, T. A.; Pan, J. Y.; Sauer, D. R.; J. Comb. Chem., 2008, 10, 88-93

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Construction of a bicyclic β-benzyloxy and β-hydroxy amide library through a multicomponent cyclization reaction

Zhang, L.; Xiao, Q.; Ma, C.; Xie, X.; Floreancig, P. E.; J. Comb. Chem., 2009, 11(4), 640-644

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Continuous enantioselective hydrogenation of activated ketones on a Pt-CD chiral catalyst: Use of H-Cube reactor system

Szollosi, G.; Herman, B.; Fulop, F.; Bartok, M.; React. Kinet. Catal. Lett., 2006, 88(2), 391-398

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Continuous flow alcoholysis of furfuryl alcohol to alkyl levulinates using zeolites

Zhao, D.; Prinsen, P.; Wang, Y.; Ouyang, W.; Delbecq, F.; Len, C.; Luque, R.; ACS Sustainable Chem. Eng., 2018, 6(5), 6901-6909

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Continuous flow biocatalysis

Britton, J.; Majumdar, S.; Weiss, G. A.; Chem. Soc. Rev., 2018, 47, 5891-5918

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Continuous-flow biochemical reactors: Biocatalysis, bioconversion, and bioanalytical applications utilizing immobilized microfluidic enzyme reactors

Hajba, L.; Guttman, A.; J. Flow Chem., 2016, 6(1), 8-12

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Continuous-flow catalytic deuterodehalogenation carried out in propylene carbonate

Mandity, I. M.; Fulop, F.; Orsy, G.; Green Chemistry, 2019, 21, 956-961

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Continuous-flow catalytic hydrogenation of 3a,6-epoxyisoindoles

Zaytsev, V. P.; Zubkov, F. I.; Mertsalov, D. F.; Orlova, D. N.; Sorokina, E. A.; Nikitina, E. V.; Varlamov, A. V.; Russian Chemical Bulletin, 2015, 64, 112-126

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Continuous flow conversion of alkyl levulinates into γ-valerolactone in the presence of Ru/C as catalyst

Zhao, D.; Wang, Y.; Delbecq, F.; Len, C.; Molecular Catalysis, 2019, 475, 110456

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Continuous flow conversion of biomass-derived methyl levulinate into γ-valerolactone using functional metal organic frameworks

Ouyang, W.; Zhao, D.; Wang, Y.; Balu, A. M.; Len, C.; Luque, R.; ACS Sustainable Chem. Eng., 2018, 6(5), 6746-6752

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Continuous-flow enzymatic resolution strategy for the acylation of amino alcohols with a remote stereogenic centre: synthesis of calycotomine enantiomers

Schonstein, L.; Forro, E.; Fulop, F.; Tetrahedron: Asymmetry, 2013, 24, 202-206

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Continuous flow fabrication of block copolymer–grafted silica micro‐particles in environmentally friendly water/ethanol media

Ye, P.; Cao, P-F.; Chen, Q.; Advincula, R.; Macromol. Mater. Eng., 2018, 1800451

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Continuous-flow high pressure hydrogenation reactor for optimization and high-throughput synthesis

Jones, R. V.; Godorhazy, L.; Varga, N.; Szalay, D.; Urge, L.; Darvas, F.; J. Comb. Chem., 2006, 8(1), 110-116

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Continuous-flow hydrogenation of D-xylose with bimetallic ruthenium catalysts on micrometric alumina

Paun, C.; Lewin, E.; Sa, J.; iMedPub., 2017

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Continuous flow hydrogenation of functionalized pyridines

Irfan, M.; Petricci, E.; Glasnov, T. N.; Taddei, M.; Kappe, C. O.; Eur. J. Org. Chem., 2009, 9, 1327-1334

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Continuous flow hydrogenation of nitroarenes, azides and alkenes using maghemite–Pd nanocomposites

Rathi, A. K.; Gawande, M. B.; Ranc, V.; Pechousek, J.; Petr, M.; Cepe, K.; Varma, R. S.; Zboril, R.; Catal. Sci. Technol., 2016, 6, 152-160

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Continuous-flow hydrogenation of olefins and nitrobenzenes catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

Osako, T.; Torii, K.; Tazawa, A.; Uozumi, Y.; RSC Adv., 2015, 5, 45760-45766

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Continuous flow (micro-)reactors for heterogeneously catalyzed reactions: Main design and modelling issues

Rossetti, I.; Catalysis Today, 2018, 308, 20-31

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Continuous-flow microreactor chemistry under high-temperature/pressure conditions

Razzaq, T.; Glasnov, T. N.; Kappe, C. O.; Eur. J. Org. Chem., 2009, 9, 1321-1325

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Continuous flow multi-step organic synthesis

Webb, D.; Jamison, T. F.; Chemical Science, 2010, 6, 675-680

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Continuous flow nanocatalysis: reaction pathways in the conversion of levulinic acid to valuable chemicals

Bermudez, J. M.; Menendez, J. A.; Romero, A. A.; Serrano, E.; Garcia-Martinez, J.; Luque, R.; Green Chem., 2013, 15(10), 2786-2792

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Continuous flow organic chemistry: successes and pitfalls at the interface with current societal challenges

Gerardy, R.; Emmanuel, N.; Toupy, T.; Kassin, V-E.; Tshibalonza, N. N.; Schmitz, M.; Monbaliu, J-C. M.; Eur. J. Org. Chem., 2018, 2018(20-21), 2301-2351

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Continuous-flow organic synthesis: a tool for the modern medicinal chemist

Wiles, C.; Watts, P.; Future Med. Chem., 2009, 1(9), 1593-1612

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Continuous flow organic synthesis under high-temperature/pressure conditions

Razzaq, T.; Kappe, C. O.; Chem. Asian J., 2010, 5(6), 1274-1289

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Continuous flow ozonolysis in a laboratory scale reactor

Irfan, M.; Glasnov, T. N.; Kappe, C. O.; Organic Letters, 2011, 13(5), 984-987

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Continuous-flow Pd-catalyzed carbonylation of aryl chlorides with carbon monoxide at elevated temperature and pressure

Mata, A.; Hone, C. A.; Gutmann, B.; Moens, L.; Kappe, C. O.; ChemCatChem, 2018, 11(3), 997-1001

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Continuous-flow processes in heterogeneously catalyzed transformations of biomass derivatives into fuels and chemicals

Serrano-Ruiz, J. C.; Luque, R.; Campelo, J. M.; Romero, A. A.; Challenges, 2012, 3, 114-132

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Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients

de Souza, R. O. M. A.; Aguiar, R.; Leao, R. A. C.; Miranda, L. S. N.; Kappe, C. O.; Cantillo, D.; Mata, A.; Org. Biomol. Chem., 2019, 17, 1552-1557

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Continuous flow reactors: a perspective

Wiles, C.; Watts, P.; Green Chem., 2012, 14, 38-54

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Continuous-flow reductive alkylation: synthesis of bio-based symmetrical and disymmetrical ethers

Bruniaux, S.; Luart, D.; Len, C.; Synthesis, 2018, 50, 1849-1856

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Continuous flow room temperature reductive aqueous homo-coupling of aryl halides using supported Pd catalysts

Feiz, A.; Bazgir, A.; Balu, A. M.; Luque, R.; Sci. Rep., 2016, 6, Article number: 32719

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Continuous flow selective hydrogenation of 5-hydroxymethylfurfural to 2,5-dimethylfuran using highly active and stable Cu-Pd/reduced graphene oxide

Mhadmhan, S.; Franco, A.; Pineda, A.; Reubroycharoen, P.; Luque, R.; ACS Sustainable Chem. Eng., 2019, 7(16), 14210-14216

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Continuous flow study of isoeugenol to vanillin: A bio-based iron oxide catalyst

Filiciotto, L.; Marquez-Medina, M. D.; Pineda, A.; Balu, A. M.; Romero, A. A.; Angelici, C.; de Jong, E.; van der Waal, J. C.; Luque, R.; Catalysis Today, 2019, accepted manuscript

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Continuous-flow syntheses of heterocycles

Glasnov, T. N.; Kappe, C. O.; J. Heterocyclic Chem., 2011, 48, 11-30

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Continuous flow synthesis. A pharma perspective

Malet-Sanz, L.; Susanne, F.; J. Med. Chem., 2012, 55(9), 4062-4098

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Contiuous-flow synthesis of deuterium-labeled antidiabetic chalcones: studies towards the selective deuteration of the alkynone core

Otvos, S. B.; Hsieh, C. T.; Wu, Y. C.; Li, J. H.; Chang, F. R.; Fulop, F.; Molecules, 2016, 21(3), 318-329

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Continuous-flow synthesis of thermochromic M-Phase VO2 particles via rapid one-step hydrothermal reaction: Effect of mixers

Yan, X.; Trevillyan, W.; Castano, I.; Sun, Y.; Muehleisen, R.; Li, J.; Journal of Nanomaterials, 2019, 2019, 2570698

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Continuous flow transfer hydrogenation of biomass derived methyl levulinate over Zr containing zeolites: Insights into the role of the catalyst acidity

Cabanillas, M.; Franco, A.; Lazaro, N.; Balu, A. M.; Luque, R.; Pineda, A.; Mol. Cat., 2019, 477, 110522

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Continuous reductive amination of biomass-derived molecules over carbonized filter paper-supported FeNi alloy

Chieffi, G.; Braun, M.; Esposito, D.; ChemSusChem, 2015, 8(21), 3590-3594

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Continuous‐flow hydrogenation and reductive deuteration of nitriles: a simple access to α,α‐dideutero amines

Meszaros, R.; Peng, B.; Otvos, S. B.; Yang, S.; Fulop F.; ChemPlusChem, 2019, 84(10), 1508-1511

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Convergent synthesis of the hexasaccharide related to the repeating unit of the O-antigen from E. coli O120

Budhadev, D.; Mukhopadhyay, B.; RSC Adv., 2015, 5, 98033-98040

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Convergent synthesis of the hexasaccharide repeating unit of the O-antigenic OPS of Escherichia coli O133

Mitra, A.; Mukhopadhyay, B.; Eur. J. Org. Chem., 2019, 2019(30), 4869-4878

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Copper-catalyzed rearragement of oximes into primary amides

Sharma, S. K.; Bishopp, S. D.; Allen, C. L.; Lawrence, R.; Bamford, M. J.; Lapkin, A. A.; Plucinski, P.; Watson, R. J.; Williams, J. M .J.; Tetrahedron Letters, 2011, 52, 4252-4255

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Covalently immobilized Trp60Cys mutant of ω-transaminase from Chromobacterium violaceum for kinetic resolution of racemic amines in batch and continuous-flow modes

Abahazi, E.; Satorhelyi, P.; Erdelyi, B.; Vertessy, B. G.; Land, H.; Paizs, C.; Berglund, P.; Poppe, L.; Biochem. Eng. J., 2018, 132, 270-278

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Cross-coupling in flow

Noel, T.; Buchwald, S. L.; Chem. Soc. Rev., 2011, 40, 5010-5029

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Cubanes in medicinal chemistry: Synthesis of functionalized building blocks

Wlochal, J.; Davies, R. D. M.; Burton, J.; Org. Lett., 2014, 16, 4094-4097

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De novo design of a picomolar nonbasic 5-HT1B receptor antagonist

Nugiel, D. A.; Krumrine, J. R.; Hill, D. C.; Damewood, J. R.; Bernstein, P. R.; Sobotka-Briner, C. D.; Liu, J. W.; Zacco, A.; Pierson, M. E.; J. Med. Chem., 2010, 53, 1876-1880

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De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments

Urich, R.; Wishart, G.; Kiczun, M.; Richters, A.; Tidten-Luksch, N.; Rauh, D.; Sherborne, B.; Wyatt, P. G.; Brenk, R.; ACS Chem. Biol., 2013, 8(5), 1044-1052

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De novo design, synthesis and pharmacological evaluation of new azaindole derivatives as dual inhibitors of Abl and Src kinases

Cheve, G.; Bories, C.; Fauvel, B.; Picot, F.; Tible, A.; Dayde-Cazals, B.; Loget, O.; Yasri, A.; Med. Chem. Commun., 2012, 3, 788-800

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Densely substituted L-proline esters as catalysts for asymmetric Michael additions of ketones to nitroalkenes

Ruiz-Olalla, A.; de Gracia Retamosa, M.; Cossio, F. P.; J. Org. Chem., 2015, 80(11), 5588-5599

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Design and development of Pd-catalyzed aerobic N-demethylation strategies for the synthesis of noroxymorphone in continuous flow mode

Gutmann, B.; Cantillo, D.; Weigl, U.; Cox, P.; Kappe, C. O.; Eur. J. Org. Chem., 2017, 914-927

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Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist

Clarke, E.; Jarvis, C. I.; Goncalves, M. B.; Kalindjian, S. B.; Adams, D. R.; Brown, J. T.; Shiers, J. J.; Taddei, D. M. A.; Ravier, E.; Barlow, S.; Miller, I., Smith, V.; Borthwick, A. D.; Corcoran, J. P. T.; Bioorg. Med. Chem., 2018, 26(4), 798-814

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Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119

Darout, E.; Robinson, R. P.; McClure, K. F.; Corbett, M.; Li, B.; Shavnya, A.; Andrews, M. P.; Jones, C. S.; Li, Q.; Minich, L. M.; Mascitti, V.; Guimaraes, C. R. W.; Munchhof, M. J.; Bahnck, K. B.; Cai, C.; Price, D. A.; Liras, S.; Bonin, P. D.; Cornelius, P.; Wang, R.; Bagdasarian, V.; Sobota, C. P.; Hornby, S.; Masterson, V. M.; Joseph, R. M.; Kalgutkar, A. S.; Chen, Y.; J. Med. Chem., 2013, 56, 301-319

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Design and synthesis of multivalent α-1,2-trimannose-linked bioerodible microparticles for applications in immune response studies of Leishmania major infection

Rintelmann, C. R.; Grinnage-Pulley, T.; Ross, K.; Kabotso, D. E. K.; Toepp, A.; Cowell, A.; Petersen, C.; Narasimhan, B.; Pohl, N.; Beilstein J. Org. Chem., 2019, 15, 623-632

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Design of a highly selective and potent class of non-planar estrogen receptor ß agonists

Sunden, H.; Ma, J. N.; Hansen, L. K.; Gustavsson, A. L.; Burstein, E. S.; Olsson, R.; ChemMedChem, 2013, 8(8), 1283-1294

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Design of experiments (DoE) and process optimization. A review of recent publications

Weissman, S. A.; Anderson, N. G.; Org. Process Res. Dev., 2015, 19(11), 1605-1633

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Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists

Cho, K.; Ando, M.; Kobayashi, K.; Miyazoe, H.; Tsujino, T.; Ito, S.; Suzuki, T.; Tanaka, T.; Tokita, S.; Sato, N.; Bioorg. Med. Chem. Lett., 2009, 19(16), 4781-4785

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Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators

Pettersson, M.; Johnson, D. S.; Subramanyam, C.; Bales, K. R.; am Ende, C. W.; Fish, B. A.; Green, M. E.; Kauffman, G. W.; Mullins, P. B.; Navaratnam, T.; Sakya, S. M.; Stiff, C. M.; Tran, T. P.; Xie, L.; Zhang, L.; Pustilnik, L. R.; Vetelino, B. C.; Wood, K. M.; Pozdnyakov, N.; Verhoest, P. R.; O'Donnell, C. J.; J. Med. Chem., 2014, 57, 1046-1062

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Development of biolubricants from vegetable oils via chemical modification

McNutt, J.; He, Q.; J. Ind. Eng. Chem., 2016, 36, 1-12

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Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors

Lawrence, H. R.; Martin, M. P.; Luo, Y.; Pireddu, R.; Yang, H.; Gevariya, H.; Ozcan, S.; Zhu, J. Y.; Kendig, R.; Rodriguez, M.; Elias, R.; Cheng, J. Q.; Sebti, S. M.; Schonbrunn, E.; Lawrence, N. J.; J. Med. Chem., 2012, 55(17), 7392-7416

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Development of second-generation indole-based dynamin GTPase inhibitors

Gordon, C. P.; Venn-Brown, B.; Robertson, M. J.; Young, K. A.; Chau, N.; Mariana, A.; Whiting, A.; Chircop, M.; Robinson, P. J.; McCluskey, A.; J. Med. Chem., 2013, 56, 46-59

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Diacylglycerol synthesis by lipase-catalyzed partial hydrolysis of palm oil under microwave irradiation and continuous flow conditions

Matos, L. M. C.; Leal, I. C. R.; de Souza, R. O. M. A.; Journal of Molecular Catalysis B: Enzymatic, 2011, 72, 36-39

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Diastereoselective 1,3-dipolar cycloaddition of pyrylium ylides with chiral enamides

Tchabanenko, K.; Sloan, C.; Bunetel, Y.; Mullen, P.; Org. Bioorg. Chem., 2012, 10, 4215-4219

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Diastereoselective [2,3]-sigmatropic rearrangement of N-allyl ammonium ylides

Murre, A.; Erkman, K.; Kaabel, S.; Jarving, I.; Kanger, T.; Synthesis, 2019, 51(22), 4183-4197

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Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assembly

Carter, C. F.; Lange, H.; Sakai, D.; Baxendale I. R.; Ley, S. V.; Chem. Eur. J., 2011, 17, 3398-3405

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Diastereoselective synthesis of cis-N-Boc-4-aminocyclohexanol with reductive ring opening method using continuous flow

Szabo, B.; Tamas, B.; Faigl, F.; Eles, J.; Greiner, I.; J. Flow Chem., 2019, 9(1), 13-17

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Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars

Bergeron-Brlek, M.; Meanwell, M.; Britton, R.; Nature Communications, 2015, 6, 6303

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Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Z.; Pinson, J. A.; Mountford, S. J.; Orive, S.; Schoenwaelder, S. M.; Shackleford, D.; Powell, A.; Nelson, E. M.; Hamilton, J. R.; Jackson, S. P.; Jennings, I. G.; Thompson, P. E.; Eur. J. Med. Chem., 2016, 122, 339-351

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Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase

Cummings, M. D.; Lin, T.; Hu, L.; Tahri, A.; McDowan, D.; Amssoms, K.; Last, S.; Devogelaere, B., Rouan, M.; Vijgen, L., Berke, J. M.; Dehertogh, P.; Fransen, E.; Cleiren, E.; van der Helm, L.; Fanning, G.; Nyanguile, O.; Simmen, K.; Remoortere, P. V.; Raboisson, P.; Vendeville, S., J. Med. Chem., 2014, 57(5), 1880-1892

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Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design

Efremov, I. V.; Vajdos, F. F.; Borzilleri, K. A.; Capetta, S.; Chen, H.; Dorff, P. H.; Dutra, J. K.; Goldstein, S. W.; Mansour, M.; McColl, A.; Noell, S.; Oborski, C. E.; O'Connell, T. N.; O'Sullivan, T. J.; Pandit, J.; Wang, H.; Wei, B.; Withka, J. M.; J. Med. Chem., 2012, 55(21), 9069-9088

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Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2

Zak, M.; Mendonca, R.; Balazs, M.; Barrett, K.; Bergeron, P.; Blair, W. S.; Chang, C.; Deshmukh, G.; DeVoss, J.; Dragovich, P. S.; Eigenbrot, C.; Ghilardi, N.; Gibbons, P.; Gradl, S.; Hamman, C.; Hanan, E.; Harstad, E.; Hewitt, P. R.; Hurley, C. A.; Jin, T.; Johnson, A.; Johnson, T.; Kenny, J. R.; Koehler, M. F. T.; Kohli, P. B.; Kulagowski, J.; Labadie, S.; Liao, J.; Liimatta, M.; Lin, Z.; Lupardus, P. J.; Maxey, R. J.; Murray, J. M.; Pulk, R.; Rodriguez, M.; Savage, S.; Shia, S.; Steffek, M.; Ubhayakar, S.; Ultsch, M.; Van-Abbema, A.; Ward, S.; Xiao, L.; Xiao, Y.; J. Med. Chem., 2012, 55(13), 6176-6193

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Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

Phillipson, L. J.; Segal, D. H.; Nero, T. L.; Parker, M. W.; Wan, S. S.; de Silva, M.; Guthridge, M. A.; Wei, A. H.; Burns, C. J.; Bioorg. Med. Chem., 2015, 23(19), 6280-6296

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Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)

Martin-Martin, M. L.; Bartolome-Nebreda, J. M.; Conde-Ceide, S.; Alonso de Diego, S. A.; Lopez, S.; Martinez-Viturro, C. M.; Tong, H. M.; Lavreysen, H.; Macdonald, G. J.; Steckler, T.; Mackie, C.; Bridges, T. M.; Daniels, J. S.; Niswender, C. M.; Noetzel, M. J.; Jones, C. K.; Conn, P. J.; Lindsley, C. W.; Stauffer, S. R.; Bioorg. Med. Chem. Lett., 2015, 25(6), 1310-1317

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Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors

Ge, Y.; Kazi, A.; Marsilio, F.; Luo, Y.; Jain. S.; Brooks, W.; Daniel, K. G.; Guida, W. C.; Sebti, S. M.; Lawrence, H. R.; J. Med. Chem., 2012, 55(5), 1978-1998

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Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation

Giordanetto, F.; Wallberg, A.; Cassel, J.; Ghosal, S.; Kossenjans, M.; Yuan, Z. Q.; Wang, X.; Liang, L.; Bioorg. Med. Chem. Lett., 2012, 22, 6665-6670

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Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)

Axten, J. M.; Medina, J. R.; Feng, Y.; Shu, A.; Romeril, S. P.; Grant, S. W.; Li, W. H. H.; Heerding, D. A.; Minthorn, E.; Mencken, T.; Atkins, C.; Liu, Q.; Rabindran, S.; Kumar, R.; Hong, X.; Goetz, A.; Stanley, T.; Taylor, J. D.; Sigethy, S. D.; Tomberlin, G. H.; Hassell, A. M.; Kahler, K. M.; Shewchuk, L. M.; Gampe, R. T.; J. Med. Chem., 2012, 55(16), 7193-7207

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Discovery of a new class of highly potent inhibitors of acid ceramidase: Synthesis and structure–activity relationship (SAR)

Pizzirani, D.; Pagliuca, C.; Realini, N.; Branduardi, D.; Bottegoni, G.; Mor, M.; Bertozzi, F.; Scarpelli, R.; Piomelli, D.; Bandiera, T.; J. Med. Chem., 2013, 56(9), 3518-3530

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Discovery of a novel chemotype of histone lysine methyltransferase EHMT1/2 (GLP/G9a) inhibitors: rational design, synthesis, biological evaluation and cocrystal structure

Milite, C.; Feoli, A.; Horton, J. R.; Rescigno, D.; Cipriano, A.; Pisapia, V.; Viviano, M.; Pepe, G.; Amendola, G.; Novellino, E.; Cosconati, S.; Cheng, X.; Castellano, S.; Sbardella, G.; J. Med. Chem., 2019, 62(5), 2666-2689

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Discovery of a novel inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) as orally active antitumor agent

Vianello, P.; Botrugno, O. A.; Cappa, A.; Zuffo, R. D.; Dessanti, P.; Mai, A.; Marrocco, B.; Mattevi, A.; Meroni, G.; Minucci, S.; Stazi, G.; Thaler, F.; Trifiro, P.; Valente, S.; Villa, M.; Mercurio, C.; J. Med. Chem., 2016, 59(4), 1501-1517

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Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours

Barlaam, B.; Cosulich, S.; Degorce, S.; Ellston, R.; Fitzek, M.; Green, S.; Hancox, U.; Lambert-van der Brempt, C.; Lohmann, J-J.; Maudet, M.; Morgentin, M.; Ple, P.; Ward, L.; Warin, N.; Bioorg. Med. Chem. Lett., 2017, 27(9), 1949-1954

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Discovery of acrylonitrile-based small molecules active against Haemonchus contortus

Gordon, C. P.; Hizartzidis, L.; Tarleton, M.; Sakoff, J. A.; Gilbert, J.; Campbell, B. E.; Gasser, R. B.; McCluskey, A.; Med. Chem. Commun., 2014, 5, 159-164

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Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models

Patel, S.; Cohen, F.; Dean, B. J.; De La Torre, K.; Deshmukh, G.; Estrada, A. A.; Ghosh, A. S.; Gibbons, P.; Gustafson, A.; Huestis, M. P.; Le Pichon, C. E.; Lin, H.; Liu, W.; Liu, X.; Liu, Y.; Ly, C. Q.; Lyssikatos, J. P.; Ma, C.; Scearce-Levie, K.; Shin, Y. G.; Solanoy, H.; Stark, K. L.; Wang, J.; Wang, B:; Zhao, X.; Lewcock, J. W.; Siu, M.; J. Med. Chem., 2015, 58(1), 401-418

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Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor

Giordanetto, F.; Wallberg, A.; Knerr, L.; Selmi, N.; Ullah, V.; Thorstensson, F.; Lindelof, L.; Karlsson, S.; Nikitidis, G.; Llinas, A.; Wang, Q. D.; Lindqvist, A.; Hogberg, L.; Lindhardt, E.; Astrand, A.; Duker, G.; Bioorg. Med. Chem. Lett., 2013, 23(1), 119-124

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Discovery of narrow spectrum kinase inhibitors: New therapeutic agents for the treatment of COPD and steroid-resistant asthma

Onions, S. T.; Ito, K; Charron, C. E.; Brown, R. J.; Colucci, M.; Frickel, F.; Hardy, G.; Joly, K.; King-Underwood, J.; Kizawa, Y.; Knowles, I.; Murray, P. J.; Novak, A.; Rani, A.; Rapeport, G.; Smith, A.; Strong, P.; Taddei, D. M.; Williams, J. G.; J. Med. Chem., 2016, 59(5), 1727-1746

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Discovery of potent and selective inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) protein kinase as potential anticancer agents

Charrier, J. D.; Durrant, S. J.; Golec, J. M. C.; Kay, D. P., Knegtel, R. M. A.; MacCormick, S.; Mortimore, M.; O'Donnell, M. E.; Pinder, J. L.; Reaper, P. M.; Rutherford, A. P.; Wang, P. S. H.; Young, S. C.; Pollard, J. R.; J. Med. Chem., 2011, 54(7), 2320-2330

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Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux

Rzasa, R. M.; Hu, E.; Rumfelt, S.; Chen, N.; Andrews, K. L.; Chmait, S.; Falsey, J. R.; Zhong, W.; Jones, A. D.; Porter, A.; Louie, S. W.; Zhao, X.; Treanor, J. J. S.; Allen, J. R.; Bioorg. Med. Chem. Lett., 2012, 22, 7371-7375

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Discovery of tertiary amine and indole derivatives as potent RORγt inverse agonists

Yang, T.; Liu, Q.; Cheng, Y.; Cai, W.; Ma, Y.; Yang, L.; Wu, Q.; Orband-Miller, L. A.; Zhou, L.; Xiang, Z.; Huxdorf, M.; Zhang, W.; Zhang, J.; Xiang-J-N.; Leung, S.; Qiu, Y.; Zhong, Z.; Elliott, J. D.; Lin, X.; Wang, Y.; ACS Med. Chem. Lett., 2014, 5(1), 65-68

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Dissection of complex molecular recognition interfaces

Hunter, C. A.; Misuraca, M. C.; Turega, S. M.; J. Am. Chem. Soc., 2011, 133(3), 582-594

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Disubstituted 1-aryl-4-aminopiperidine library synthesis using computational drug design and high-throughput batch and flow technologies

Bryan, M. C.; Hein, C. D.; Gao, H.; Xia, X.; Eastwood, H.; Bruenner, B. A.; Louie, S. W.; Doherty, E. M; ACS Comb. Sci., 2013, 15(9), 503-511

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Diversity-oriented synthesis of a library of star-shaped 2H-imidazolines

Yu, X.; Guttenberger, N.; Fuchs, E.; Peters, M.; Weber, H.; Breinbauer R.; ACS Comb. Sci., 2015, 17(11), 682-690

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Diversity-oriented synthesis of dibenzoazocines and dibenzoazepines via a microwave-assisted intramolecular A3-coupling reaction

Bariwal, J. B.; Ermolat'ev, D. S.; Glasnov, T. N.; Van Hecke, K.; Mehta, V. P.; Van Meervelt, L.; Kappe, C. O.; Van der Eycken, E. V.; Org. Lett., 2010, 12(12), 2774-2777

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Doping carbon networks with phosphorus for supporting Pd in catalyzing selective oxidation of benzyl alcohol

Guo, W.; Niu, S.; Ji, X.; Yu, W.; Lin, T-W.; Wu, Y.; Li, Y.; Shao, L.; J. Nanopart. Res.; 2018, 20:180

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Double carbonylation of iodobenzene in a microfluidics-based high throughput flow reactor

Balogh, J.; Kuik, A.; Urge, L.; Darvas, F.; Bakos, J.; Skoda-Foldes, R.; Journal of Molecular Catalysis A: Chemical, 2009, 302, 76-79

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Easy access to Ni3N- and Ni-carbon nanocomposite catalysts

Clavel, G.; Molinari, V.; Kraupner, A.; Giordano, C.; Chem. Eur. J., 2014, 20(29), 9018-9023

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Eco-efficiency analysis for intensified production of an active pharmaceutical ingredient: a case study

Dencic, I.; Ott, D.; Kralisch, D.; Noel, T.; Meuldijk, J.; de Croon, M.; Hessel, V.; Laribi, Y.; Perrichon, P.; Org. Process Res. Dev., 2014, 18(11), 1326-1338

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Efficient and scalable synthesis of thiazole fused benzazepine as a D2 partial agonist

Xiong, H.; Wu, Y.; Lehr, S. G.; Blackwell, W.; Steelman, G.; Hulsizer, J.; Urbanek, R. A.; Tetrahedron Letters, 2012, 53(44), 5833-5836

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Efficient continuous-flow synthesis of novel 1,2,3-triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production

Otvos, S. B.; Georgiades, A.; Mandity, I. M.; Kiss, L.; Fulop, F.; Beilstein J. Org. Chem., 2013, 9, 1508-1516

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Electrochemical phenylselenoetherification as a key step in the synthesis of (±)-curcumene ether

Stevanovic, D.; Pejovic, A.; Damljanovic, I. S.; Vukicevic, M. D.; Dobrikov, G.; Dimitrov, V.; Denic, M. S.; Radulovic, N. S.; Vukicevic, R. D.; Helvetica Chimica Acta, 2013, 96(6), 1103-1110

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Electrophile-induced dearomatizing spirocyclization of N-arylisonicotinamides: A route to spirocyclic piperidines

Arnott, G.; Brice, H.; Clayden, J.; Blaney, E.; Organic Letters, 2008, 10(14), 3089-3092

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Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4)

Day, J. P.; Lindsay, B.; Riddel, T.; Jiang, Z.; Allock, R. W.; Abraham, A.; Sookup, S.; Christian, F.; Bogum, J.; Martin, E. K.; Rae, R. L.; Anthony, D.; Rosair, G. M.; Houslay, D. M.; Huston, E.; Baillie, G. S.; Klussmann, E.; Houslay, M. D.; Adams, D. R.; J. Med. Chem., 2011, 54(9), 3331-3347

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Emerging trends in flow chemistry and applications to the pharmaceutical industry

Bogdan, A. R.; Dombrowski, A. W.; J. Med. Chem., 2019, 62(14), 6422-6468

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Enabling the scale-up of a key asymmetric hydrogenation step in the synthesis of an API using continuous flow solid-supported catalysis

Amara, Z.; Poliakoff, M.; Duque, R.; Geier, D.; Francio, G.; Gordon, C. M.; Meadows, R. E.; Woodward, R.; Leitner, W.; Org. Process Res. Dev., 2016, 20, 1321-1327

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Enantiodivergent synthesis of bis-spiropyrrolidines via sequential interrupted and completed (3+2) cycloadditions

Conde, E.; Rivilla, I.; Larumbe, A.; Cossio F. P.; J. Org. Chem., 2015, 80(23), 11755-11767

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Enantiomer selective acylation of racemic alcohols by lipases in continuous-flow bioreactors

Csajagi, Cs.; Szatzker, G.; Toke, E. R.; Urge, L.; Darvas, F.; Poppe, L.; Tetrahedron: Asymmetry, 2008, 19(2), 237-246

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Enantiomeric separation of bicyclo[2.2.2]octane‐based 2‐amino‐3‐carboxylic acids on macrocyclic glycopeptide chiral stationary phases

Pataj, Z.; Ilisz, I.; Grecso, N; Palko, M.; Fulop, F.; Armstrong, D. W.; Peter, A.; Chirality, 2014, 26, 200-208

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Enantioselective access to benzannulated spiroketals using a chiral sulfoxide auxiliary

Aitken, H. R. M.; Furkert, D. P.; Hubert, J. G.; Wood, J. M.; Brimble, M. A.; Org. Biomol. Chem., 2013, 11, 5147-5155

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Enantioselective hydrogenation of α,β-unsaturated carboxylic acids in fixed-bed reactor

Herman, B.; Szollosi, G.; Fulop F.; Bartok, M.; Applied Catalysis A: General, 2007, 331, 39-43

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Enantioselective hydrolysis of 3,4-disubstituted β-lactams. An efficient enzymatic method for the preparation of a key Taxol side-chain intermediate

Galla, Zs.; Beke, F.; Forro, E.; Fulop, F.; Journal of Molecular Catalysis B: Enzymatic, 2016, 123, 107-112

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Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary

Jones, A. L.; Liu, X.; Snyder, J. K.; Tetrahedron Letters, 2010, 51(7), 1091-1094

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Enantioselective synthesis of bicyclo[2.2.2]octenones using a copper-mediated oxidative dearomatization/[4+2] dimerization cascade

Dong, S.; Zhu, J.; Porco, J. A.; J. Am. Chem. Soc., 2008, 130(9), 2738-2739

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Enantioselective synthesis of (+)-Chamaecypanone C: A novel microtubule inhibitor

Dong, S.; Hamel, E.; Bai, R.; Covell, D. G.; Beutler, J. A.; Porco, J .A.; Angew. Chem. Int. Ed., 2009, 48(8), 1494-1497

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endo-Hydroxamic acid monomers for the assembly of a suite of non-native dimeric macrocyclic siderophores using metal-templated synthesis

Brown, C. J. M.; Gotsbacher, M. P.; Holland, J. P.; Codd, R.; Inorg. Chem., 2019, 58(20), 13591-13603

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Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction

Liu, Q.; Wu, K.; Cheng, Y.; Lu, L.; Xiao, E.; Zhang, Y.; Deng, Z.; Liu, T.; Metabolic Engineering, 2015, 28, 82-90

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Enhanced biocatalytic performance of bacterial laccase from Streptomyces sviceus: Application in the Michael addition sequence towards 3‐arylated 4‐oxochromanes

Suljic, S.; Mortzfeld, F. B.; Gunne, M.; Urlacher, V. B.; Pietruszka, J.; ChemCatChem, 2015, 7(8), 1380-1385

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Environmentally friendly synthesis of indoline derivatives using flow-chemistry techniques

Orkenyi, R.; Beke, G.; Riethmuller, E.; Szakacs, Z.; Koti, J.; Faigl, F.; Eles, J.; Greiner, I.; Eur. J. Org. Chem., 2017, 6525-6532

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Enzymatic reactions for the preparation of homocalycotomine enantiomers

Schonstein, L.; Forro, E.; Fulop, F.; Tetrahedron: Asymmetry, 2013, 24, 1059-1062

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Enzymatic strategy for the resolution of new 1‐hydroxymethyl tetrahydro‐β‐carboline derivatives in batch and continuous‐flow systems

Megyesi, R.; Forro, E.; Fulop, F.; ChemistryOpen, 2016, 5(3), 254-260

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Epoxy resin monomers with reduced skin sensitizing potency

O'Boyle, N. M.; Niklasson, I. B.; Tehrani-Bagha, A. R.; Delaine, T.; Holmberg, K.; Luthman, K.; Karlberg, A. T.; Chem. Res. Toxicol., 2014, 27(6), 1002-1010

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Evaluating dynamic kinetic resolution strategies in the asymmetric hydrosilylation of cyclic ketimines

Jones, S.; Zhao, P.; Tetrahedron: Asymmetry, 2014, 25(3), 238-244

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Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis

Bryan, M. C.; Wernick, D.; Hein, C. D.; Petersen, J. V.; Eschelbach, J. W.; Doherty, E. M.; Beilstein J. Org. Chem., 2011, 7, 1141-1149

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Evaluation of bifunctional chiral phosphine oxide catalysts for the asymmetric hydrosilylation of ketimines

Warner, C. J. A.; Berry, S. S.; Jones, S.; Tetrahedron, 2019, accepted manuscript

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Evaluation of functional groups as acetyl-lysine mimetics for BET bromodomain inhibition

Sharp, P. P.; Garnier, J-M.; Huang, D. C. S.; Burns, C. J.; MedChemCommun, 2014, 5, 1834-1842

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Evaluation of SILP-Pd catalysts for Heck reactions in amicrofluidics-based high throughput flow reactor

Urban, B.; Sranko, D.; Safran, G.; Urge, L.; Darvas, F.; Bakos, J.; Skoda-Foldes, R.; Journal of Molecular Catalysis A: Chemical, 2014, 395, 364-372

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Expanding the toolbox of asymmetric organocatalysis by continuous-flow process

Finelli, F. G.; Miranda, L. S. M.; de Souza, R. O. M. A.; Chem. Commun., 2015, 51, 3708-3722

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Expanding the utility of flow hydrogenation – a robust protocol restricting hydrodehalogenation

Hizartzidis, L.; Cossar, P. J.; Robertson, M. J.; Simone, M. I.; Young, K. A.; McCluskey, A.; Gordon, C. P.; RSC Adv., 2014, 4, 56743-56748

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Expedient Diels–Alder cycloadditions with ortho-quinodimethanes in a high temperature/pressure flow reactor

Tsoung, J.; Wang, Y.; Djuric, S. W.; React. Chem. Eng., 2017, 2, 458-461

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Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a]pyridine: expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines

Bazin, M. A.; Marhadour, S.; Tonnerre, A.; Marchand, P.; Tetrahedron Letters, 2013, 54(39), 5378-5382

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Facile access to new C-glycosides and C-glycoside scaffolds incorporating functionalised aromatic moieties

Redpath, P.; Ness, K. A.; Rousseau, J.; Macdonald, S. J. F.; Migaud, M. E.; Carbohydrate Research, 2015, 402, 25-34

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Facile arene hydrogenation under flow conditions catalyzed by rhodium or ruthenium on carbon

Hattori, T.; Ida, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Eur. J. Org. Chem., 2015, 2015(11), 2492-2497

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Facile conversion of red phosphorus into soluble polyphosphide anions by reaction with potassium ethoxide

Dragulescu-Andrasi, A.; Miller, L. Z.; Chen, B.; McQuade, D. T.; Shatruk M.; Angew. Chem. Int. Ed., 2016, 55(12), 3904-3908

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Fast continuous alcohol amination employing a hydrogen borrowing protocol

Labes, R.; Mateos, C., Battilocchio, C.; Chen, Y.; Dingwall, P.; Cumming, G. R.; Rincon, J. A.; Nieves-Remacha, M. J.; Ley, S. V.; Green Chemistry, 2019, 21, 59-63

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Fatty acids residue from palm oil refining process as feedstock for lipase catalyzed monoacylglicerol production under batch and continuous flow conditions

Junior, I. I.; Flores, M. C.; Sutili, F. K.; Leite, S. G. F.; de M. e Miranda, L. S.; Leal, I. C. R.; de Souza, R. O. M. A.; Journal of Molecular Catalysis B: Enzymatic, 2012, 77, 53-58

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Features of oxa-bridge cleavage in hexahydro-3a,6-epoxyisoindol-1(4H)-ones: A concise method to access acetylisoindolones possessing anti-viral activity

Zaytsev, V. P.; Mertsalov, D. F.; Chervyakova, L. V.; Krishna, G.; Zubkov, F. I.; Dorovatovski, P. V.; Khrustalev, V. N.; Zarubaev, V. V.; Tetrahedron Lett., 2019, 60(43), 151204

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FeNi nanoparticles with carbon armor as sustainable hydrogenation catalysts: towards biorefineries

Chieffi, G.; Giordano, C.; Antonietti, M.; Esposito, D.; Journal of Materials Chemistry A, 2014, 2, 11591-11596

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Fine chemical syntheses under flow using SiliaCat catalysts

Ciriminna, R.; Pandarus, V.; Beland, F.; Pagliaro, M.; Catal. Sci. Technol., 2016, 6(13), 4678-4685

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First enantioselective total synthesis of (+)-(R)-pinnatolide using an symmetric domino allylation reaction

Tietze, L. F.; Wolfram, T.; Holstein, J. J.; Dittrich, B.; Org. Lett., 2012, 14(16), 4035-4037

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First example of alkyl–aryl Negishi cross-coupling in flow: Mild, efficient and clean introduction of functionalized alkyl groups

Egle, B.; Munoz, J.; Alonso, N.; De Borggraeve, W. M., de la Hoz, A.; Diaz-Ortiz, A.; Alcazar, J.; J. Flow Chem., 2014, 4(1), 22-25

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Flash carboxylation: fast lithiation-carboxylation sequence at room temperature in continuous flow

Pieber, B.; Glasnov, T.; Kappe, C. O.; RSC Adv., 2014, 4, 13430-13433

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Flash flow pyrolysis: Mimicking flash vacuum pyrolysis in a high-temperature/high-pressure liquid-phase microreactor environment

Cantillo, D.; Sheibani, H.; Kappe, C. O.; J. Org. Chem., 2012, 77(5), 2463-2473

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Flow chemistry – A key enabling technology for (multistep) organic synthesis

Wegner, J.; Ceylan, S.; Kirschning, A.; Adv. Synth. Catal., 2012, 354, 17-57

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Flow chemistry approach for partial deuteration of alkynes: synthesis of deuterated taxol side chain

Chandrasekhar, S.; Vijaykumar, B. V. D.; Mahesh Chandra, B.; Raji Reddy, Ch.; Naresh, P.; Tetrahedron Letters, 2011, 52, 3865-3867

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Flow chemistry approaches directed at improving chemical synthesis

Baxendale, I. R.; Brocken, L.; Mallia, C. J.; Green Process. Synth., 2013, 2(3), 211-230

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Flow chemistry as a versatile tool for the synthesis of triazoles

Otvos, S. B.; Fulop, F.; Catal. Sci. Technol., 2015, 5(11), 4926-4941

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Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation

Mandity, I.; Fulop, F.; Nekka, I.; Bogdan, D.; Gati, T.; Beni, S.; Juhasz, T.; Palko, M.; Paragi, G.; Toth, G.; Chem. Commun., 2019, 55, 3061-3064

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Flow chemistry for designing sustainable chemical synthesis

Vaddula, B. R.; Gonzalez, M. A.; Chimica Oggi – Chemistry Today, 2013, 31, 16-20

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Flow chemistry: Intelligent processing of gas-liquid transformations using a tube-in-tube reactor

Brzozowski, M.; O'Brien, M.; Ley, S. V.; Polyzos, A.; Acc. Chem. Res., 2015, 48(2), 349-362

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Flow chemistry syntheses of natural products

Pastre, J. C.; Browne, D. L.; Ley, S. V.; Chem. Soc. Rev., 2013, 42, 8849-8869

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Flow chemistry: Towards a more sustainable heterocyclic synthesis

Brandao, P.; Pineiro, M.; Pinho e Melo, T. M. V. D.; Eur. J. Org. Chem., 2019, 2019(43), 7188-7217

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Flow chemistry vs. flow analysis

Trojanowicz, M.; Talanta, 2016, 146, 621-640

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Flow fine synthesis with heterogeneous catalysts

Masuda, K.; Ichitsuka T.; Koumura, N.; Sato, K.; Kobayashi, S.; Tetrahedron, 2018, 74(15), 1705-1730

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Flow hydrogenation of p-nitrophenol with nano-Ag/Al2O3

Paun, C.; Slowik, G.; Lewin, E.; Sa, J.; RSC Adv., 2016, 6, 87564-87568

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Flow-oriented synthetic design in the continuous preparation of the aryl piperazine drug flibanserin

Bana, P.; Szigetvari, A.; Koti, J.; Eles, J.; Greiner, I.; React. Chem. Eng., 2019, 4, 652-657

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Flow reactors for drug discovery flow for reaction optimization, library synthesis, and scale up

Jones, R. V.; Csajagi, Cs.; Szekelyhidi, Zs.; Kovacs, I.; Borcsek, B.; Urge, L.; Darvas, F.; Chemistry Today, 2008, 26(3), 10-13

Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe

Plutschack, M. B.; McQuade, D. T.; Valenti, G.; Seeberger, P. H.; Beilstein J. Org. Chem., 2013, 9, 2022-2027

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Flow synthesis of annulated 5-aryl-substituted pyridines by tandem intramolecular inverse-electron-demand hetero-/retro-Diels–Alder reaction

Martin, R. E.; Lenz, M.; Alzieu, T.; Aebi, J. D.; Forzy, L.; Tetrahedron Letters, 2013, 54(49), 6703-6707

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Formation of benzocyclobutenes from substituted oxocycloocta-2,8-diene-1,2-dicarboxylates

Bezensek, J.; Groselj, U.; Pockaj, M.; Svete, J.; Stanovnik, B.; Tetrahedron Letters, 2015, 56(42), 5705-5708

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Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors

Saluste, G.; Albarran, M. I.; Alvarez, R. M.; Rabal, O.; Ortega, M. A.; Blanco, C.; Kurz, G.; Salgado, A.; Pevarello, P.; Bischoff, J. R.; Pastor, J.; Oyarzabal, J.; PLoS One, 2012, 7(10), e45964

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From the Lindlar catalyst to supported ligand‐modified palladium nanoparticles: selectivity patterns and accessibility constraints in the continuous‐flow three‐phase hydrogenation of acetylenic compounds

Vile, G.; Almora-Barrios, N.; Mitchell, S.; Lopez, N.; Perez-Ramirez, J.; Chem. Eur. J., 2014, 20, 5926-5937

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Fully automated sequence-specific synthesis of α-peptides using flow chemistry

Knudsen, K. R.; Ladlow, M.; Bandpey, Z.; Ley, S. V.; J. Flow Chem., 2014, 4(1), 18-21

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Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation

Brice, H.; Clayden, J.; Hamilton, S. D.; Beilstein J. Org. Chem., 2010, 6(22)

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General methods for the synthesis and late-stage diversification of 2,4-substituted 7-azaindoles

Varnes, J. G.; McGuire, T.; Meadows, R. E.; Barlaam, B.; Clark, J.; Cook, C. R.; Davison, G.; Dishington, A.; De Savi, C.; Donald, C.; Grebe, T.; Hande, S.; Hawkins, J.; Hird, A. W.; Holmes, J.; Lister, A.; Lucas, S.; Moore, J.; Moore, E.; Patel, A.; Pike, K. G.; Roberts, B.; Stark, A.; Stead, D.; Thakur, K.; Turner, P.; Vasbinder, M.; Yang, B.; Tetrahedron Letters, 2016, 57, 4718-4722

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Gram scale de novo synthesis of 2,4-diacetamido-2,4,6-trideoxy-d-galactose

Schmolzer, C.; Nowikow, C.; Kahlig, H.; Schmid, W.; Carbohydrate Research, 2013, 367, 1-4

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Green and scalable procedure for extremely fast ligandless Suzuki-Miyaura cross-coupling reactions in aqueous IPA using solid-supported Pd in continuous flow

Mateos, C.; Rincon, J. A.; Martin-Hidalgo, B.; Villanueva, J.; Tetrahedron Letters, 2014, 55(27), 3701-3705

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Green chemistry articles of interest to the pharmaceutical industry

Andrews, I.; Dunn, P.; Hayler, J.; Himkley, B.; Hughes, D.; Kaptein, B.; Lorenz, K.; Methew, S.; Rammeloo, T.; Wang, L.; Wells, A.; White, T. D.; Org. Process Res. Dev., 2011, 15, 748-756

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Harnessing the versatility of continuous-flow processes: selective and efficient reactions

Mandity, I. M.; Otvos, S. B.; Szolosi, G.; Fulop, F.; Chem. Rec., 2016, 16, 1018-1033

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Hazards associated with laboratory scale hydrogenations

Chandra, T.; Zebrowski; J. P.; Journal of Chemical Health and Safety, 2016, 23(4), 16-25

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Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons

Belema, M.; Nguyen, V. N.; Romine, J. L.; St. Laurent, D. R.; Lopez, O. D.; Goodrich, J. T.; Nower, P. T.; O'Boyle, D. R.; Lemm, J. A.; Fridell, R. A.; Gao, M.; Fang, H.; Krause, R. G.; Wang, Y.; Oliver, A. J.; Good, A. C.; Knipe, J. O.; Meanwell, N. A.; Snyder, L. B.; J. Med. Chem., 2014, 57, 1995-2012

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Heterogeneous catalysis in continuous flow microreactors: a review of methods and applications

Tanimu, A.; Jaenicke, S.; Alhooshani, K.; Chem. Eng. J., 2017, 327, 792-821

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Heterogeneous catalytic hydrogenation reactions in continuous-flow reactors

Irfan, M.; Glasnov, N. T.; Kappe, O. C.; ChemSusChem, 2011, 12(3), 300-316

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Heterogeneous catalytic synthesis using microreactor technology

Frost, C. G.; Mutton, L.; Green Chem., 2010, 12, 1687-1703

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Heterogeneous enantioselective hydrogenation in a continuous-flow fixed-bed reactor system: Hydrogenation of activated ketones and their binary mixtures on Pt–alumina–cinchona alkaloid catalysts

Szollosi, G.; Makra, Zs.; Fekete, M.; Fulop, F.; Bartok, M.; Catal. Lett., 2012, 142(7), 889-894

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Heterogeneous hydrogenation reactions using a continuous flow high pressure device

Desai, B.; Kappe, C. O.; J. Comb. Chem., 2005, 7(5), 641-643

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Heterogeneous versus homogeneous palladium catalysts for ligandless Mizoroki-Heck reactions: A comparison of batch/microwave and continuous‐flow processing

Glasnov, T. N.; Findenig, S.; Kappe, C. O.; Chem. Eur. J., 2009, 15, 1001-1010

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High-efficiency aminocarbonylation by introducing CO to a pressurized continuous flow reactor

Csajagi, Cs.; Borcsek, B.; Niesz, K.; Kovacs, I.; Szekelyhidi, Zs.; Bajko, Z.; Ugre, L.; Darvas, F.; Org. Lett., 2008, 10(8), 1589-1592

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High pressure in organic chemistry on the way to miniaturization

Benito-Lopez, F.; Egberink, E. J. M.; Reinhoudt, D. N.; Verboom, W.; Tetrahedron, 2008, 64(43), 10023-10040

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High-speed microwave assisted synthesis of SEA0400 – a selective inhibitor of the Na+/Ca2+ exchanger

de la Cruz, G. G.; Groschner, K.; Kappe, C. O.; Glasnov; T. N.; Tetrahedron Letters, 2012, 53, 3731-3734

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High-temperature Boc deprotection in flow and its application in multistep reaction sequences

Bogdan, R. A.; Charaschanya, M.; Dombrowski, A. W.; Wang, Y.; Djuric, S. W.; Org. Lett., 2016, 18(8), 1732-1735

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Highly active catalytic Ru/TiO2 nanomaterials for continuous production of γ-valerolactone

Xu, C.; Ouyang, W.; Munoz-Batista, M. J.; Fernandez-Garcia, M.; Luque, R.; ChemSusChem, 2018, 11(15), 2604-2611

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Highly efficient 1,4-addition of aldehydes to nitroolefins

Otvos, S. B.; Mandity, I. M.; Fulop, F.; ChemSusChem, 2012, 5, 266-269

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Highly efficient iron(0) nanoparticle-catalyzed hydrogenation in water in flow

Hudson, R.; Hamasaka, G.; Osako, T.; Yamada, Y. M. A.; Li, C-J.; Uozumi, Y.; Moores, A.; Green Chem., 2013, 15, 2141-2148

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Highly efficient reversible addition-fragmentation chain‐transfer polymerization in ethanol/water via flow chemistry

Ye, P.; Cao, P-F.; Su, Z.; Advincula, R.; Polymer Int., 2017, 66(9), 1252-1258

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Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives

Lengyel, L.; Nagy, T. Zs.; Sipos, G.; Jones, R.; Dorman, Gy.; Urge, L.; Darvas, F.; Tetrahedron Letters, 2012, 53(7), 738-743

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Highly selective continuous-flow synthesis of potentially bioactive deuterated chalcone derivatives

Hsieh, C.; Otvos, S. B.; Wu, Y.; Mandity, I. M.; Chang, F.; Fulop, F.; ChemPlusChem, 2015, 80(5), 859-864

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Highly selective deuteration of pharmaceutically relevant nitrogen-containing heterocycles: a flow chemistry approach

Otvos, S. B.; Mandity, I. M.; Fulop, F.; Mol. Divers., 2011, 15, 605-611

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Highly selective hydrogenation of R‑(+)-limonene to (+)-p- 1‑menthene in batch and continuous flow reactors

Rubulotta, G.; Luska, K. L.; Urbina-Blanco, C. A.; Eifert, T.; Palkovits, R.; Quadrelli, E. A.; Thieuleux, C.; Leitner, W.; ACS Sustainable Chem. Eng., 2017, 5, 3762-3767

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Hit optimization of 5-substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) inhibitors with in vivo activity in model of mood disorders

Furlotti, G.; Alisi, M. A.; Cazzolla, N.; Dragone, P.; Durando, L.; Magaro, G.; Mancini, F.; Mangano, G.; Ombrato, R.; Vitiello, M.; Armirotti, A.; Capurro, V.; Lanfranco, M.; Ottonello, G.; Summa, M.; Reggiani, A.; J. Med. Chem., 2015, 58(22), 8920-8937

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HKUST-1 silica aerogel composites: novel materials for the separation of saturated and unsaturated hydrocarbons by conventional liquid chromatography

Nuzhdin, A. L.; Shalygin, A. S.; Artiukha, E. A.; Chibiryaev, A. M.; Bukhtiyarova, G. A.; Martyanov, O. N.; RSC Adv., 2016, 6, 62501-62507

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Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

Manzoni, L.; Belvisi, L.; Bianchi, A.; Conti, A.; Drago, C.; de Matteo, M.; Ferrante, L.; Mastrangelo, E.; Perego, P.; Potenza, D.; Scolastico, C.; Servida, F.; Timpano, G.; Vasile, F., Rizzo, V.; Seneci, P.; Bioorg. Med. Chem., 2012, 20, 6687-6708

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How the mode of Candida antarctica lipase B immobilization affects the continuous-flow kinetic resolution of racemic amines at various temperatures

Boros, Z.; Falus, P.; Markus, M.; Weiser, D.; Olah, M.; Hornyanszky, G.; Nagy, J.; Poppe, L.; Journal of Molecular Catalysis B: Enzymatic, 2013, 85-86, 119-125

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Hydrogenation of nitroarenes to anilines in a flow reactor using polystyrene supported rhodium in a catalyst-cartridge (Cart-Rh@PS)

Sharma, S.; Yamini; Das, P.; New J. Chem., 2018, 43, 1764-1769

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Hydrothermal formose reaction

Kopetzki, D.; Antonietti, M.; New J. Chem., 2011, 35, 1787-1794

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Identification and Characterization of Carprofen as a Multitarget Fatty Acid Amide Hydrolase/Cyclooxygenase Inhibitor

Favia, A. D.; Habrant, D.; Scarpelli, R.; Migliore, M.; Albani, C.; Bertozzi, S. M.; Dionisi, M.; Tarozzo, G.; Piomelli, D.; Cavalli, A.; De Vivo, M.; J. Med. Chem., 2012, 55, 8807-8826

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Identification of a novel orally bioavailable phosphodiesterase 10A inhibitor with efficacy in animal models of schizophrenia

Bartolome-Nebreda, J. M.; de Diego, S. A. A.; Artola, M.; Delgado, F.; Delgado, O.; Martin-Martin, M. L.; Martinez-Viturro, C. M.; Pena, M. A.; Tong, H. M.; Van Gool, M.; Alonso, J. M.; Fontana, A.; Macdonald, G. J.; Megens, A.; Langlois, X.; Somers, M.; Vanhoof, G.; Conde-Ceide, S.; J. Med. Chem., 2015, 58(2), 978-993

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Immobilized iron oxide nanoparticles as stable and reusable catalysts for hydrazine‐mediated nitro reductions in continuous flow

Moghaddam, M. M.; Pieber, B.; Glasnov, T.; Kappe, C. O.; ChemSusChem, 2014, 7(11), 3122-3131

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Immobilized phosphine–phosphite rhodium complexes: highly active and enantioselective catalysts for asymmetric hydrogenation under continuous flow conditions

Madarasz, J.; Nanasi, B.; Kovacs, J.; Balogh, S.; Farkas, G.; Bakos, J.; Monatsh. Chem., 2018, 149(1), 19-25

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Immobilized transition metals as catalysts for cross-couplings in continuous flow — A critical assessment of the reaction mechanism and metal leaching

Cantillo, D.; Kappe, C. O.; ChemCatChem, 2014, 6(12), 3286-3305

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Important industrial procedures revisited in flow: very efficient oxidation and N-alkylation reactions with high atom-economy

Sipos, G.; Gyollai, V.; Dorman, G.; Kocsis, L.; Jones, R. V.; Darvas, F.; Journal of Flow Chemistry, 2013, 3(2), 51-58

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Improved and scalable synthesis of building blocks for the modular synthesis of teraryl-based alpha-helix mimetics

Trobe, M.; Breinbauer, R.; Monatsh. Chem., 2016, 147(3), 509-521

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Improved continuous flow processing: benzimidazole ring formation via catalytic hydrogenation of an aromatic nitro compound

Chen, J.; Przyuski, K.; Roemmele, R.; Bakale, R. P.; Org. Process Res. Dev., 2014, 18(11), 1427-1433

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Improving productivity of multiphase flow aerobic oxidation using a tube-in-tube membrane contactor

Burkholder, M.; Gilliland, S. E.; Luxon, A.; Tang, C.; Gupton, B. F.; Catalysts, 2019, 9(1), 95

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In situ sulfidation of Pd/C: A Straightforward method for chemoselective conjugate reduction by continuous hydrogenation

Moore, J. C.; Howie, R. A.; Bourne, S. L.; Jenkins, G. N.; Licence, P.; Poliakoff, M.; George, M. W.; ACS Sustainable Chem. Eng., 2019, 7(19), 16814-16819

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In vitro reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors

Tan, G-Y.; Zhu, F.; Deng, Z.; Liu, T.; Synthetic and Systems Biotechnology, 2016, 1, 25-33

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Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites

Shamovsky, I.; de Graaf, C.; Alderin, L.; Bengtsson, M.; Bladh, H.; Börjesson, L.; Connolly, S.; Dyke, H. J.; van den Heuvel, M.; Johansson, H.; Josefsson, B.; Kristoffersson, A.; Linnanen, T.; Lisius, A.; Mannikko, R.; Norden, B.; Price, S.; Ripa, L.; Rognan, D.; Rosendahl, A.; Skrinjar, M.; Urbahns, K.; J. Med. Chem., 2009, 52, 7706-7723

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Innovative benign-by-design flow chemistry protocols: from bio(nano)materials synthesis to biomass/waste valorisation

Wang, B.; Balu, A. M.; Xuan, J.; Gonzalez-Arellano, C.; Bai, Z.; Luque, R.; Chemistry Today, 2016, 34(6), 58-63

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Insights into the activity, selectivity and stability of heterogeneous catalysts in the continuous flow hydroconversion of furfural

Garcia-Olmo, A. J.; Yepez, A.; Balu, A. M.; Romero, A. A.; Li, Y.; Luque, R.; Catal. Sci. Technol., 2016, 6(13), 4705-4711

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Insights into the selective hydrogenation of levulinic acid to γ-valerolactone using supported mono- and bimetallic catalysts

Al-Naji, M.; Yepez, A.; Balu, A. M.; Romero, A. A.; Chen, Z.; Wilde, N.; Li, H.; Shih, K.; Glaser, R.; Luque, R.; Journal of Molecular Catalysis A: Chemical, 2016, 417, 145-152

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Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Ingham, R. J.; Battilocchio, C.; Hawkins, J. M.; Ley, S. V.; Beilstein J. Org. Chem., 2014, 10, 641-652

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Interesting applications on a novel high pressure high temperature microfluidic-based flow reactor

Niesz, K.; Csajagi, Cs.; Borcsek, B.; Jones, R. V.; Darvas, F.; Nanotechnology, 2007, 4, 426-429

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Intramolecular aglycon delivery enables the synthesis of 6-deoxy-β-d-manno-heptosides as fragments of Burkholderia pseudomallei and Burkholderia mallei capsular polysaccharide

Kenfack, M. T.; Bleriot, Y.; Gauthier, C.; J. Org. Chem., 2014, 79(10), 4615-4634

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Investigation, optimization and synthesis of sulfamoyloxy-linked aminoacyl-AMP analogues

Redwan, I. N.; Ljungdahl, T.; Grotli, M.; Tetrahedron, 2012, 68(5), 1507-1514

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Ion exchange resins: Catalyst recovery and recycle

Barbaro, P.; Liguori, F.; Chem. Rev., 2009, 109(2), 515-529

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Iridium(I)-catalyzed ortho-directed hydrogen isotope exchange in continuous-flow reactors

Habraken, E.; Haspeslagh, P.; Vliegen, M.; Noel, T.; J. Flow Chem., 2015, 5(1), 2-5

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Iridium(I)-NHC-phosphine complex-catalyzed hydrogen generation and storage in aqueous formate/bicarbonate solutions using a flow reactor – Effective response to changes in hydrogen demand

Horvath, H.; Papp, G.; Kovacs, H.; Katho, A.; Joo, F.; Int. J. Hydrogen Energy, 2019, 44(53), 28527-28532

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Isolation and characterization of anti-adenoviral secondary metabolites from marine actinobacteria

Strand, M.; Carlsson, M.; Uvell, H.; Islam, K.; Edlund, K.; Cullman, I.; Altermark, B.; Mei, Y-F.; Elofsson, M.; Willassen, N. P.; Wadell, G.; Almqvist, F. Mar. Drugs, 2014, 12(2), 799-821

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Landscape and opportunities for active pharmaceutical ingredient manufacturing in developing African economies

Panayides, J. L.; Riley, D. L.; Chikwamba, R.; Strydom, I.; React. Chem. Eng., 2019, 4, 457-489

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Latest highlights in liquid-phase reactions for organic synthesis in microreactors

Protasova, L. N.; Bulut, M.; Ormerod, D.; Buekenhoudt, A.; Berton, J.; Stevens, C. V.; Org. Process Res. Dev., 2013, 17(5), 760-791

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Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound

Tarleton, M.; Gilbert, J; Robertson, J. M.; McCluskey, A.; Sakoff, A. J; MedChemComm, 2011, 2, 31-37

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Library synthesis of cardiomyogenesis inducing compounds using an efficient two-step-one-flow process

Schon, M.; Dreier, D.; Schnurch, M.; Mihovilovic, M. D.; Monatsh. Chem., 2016, 147(3), 523-532

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Life cycle analysis within pharmaceutical process optimization and intensification: case study of active pharmaceutical ingredient production

Ott, D.; Kralisch, D.; Dencic, I.; Hessel, V.; Laribi, Y.; Perrichon, P. D.; Berguerand, C.; Kiwi-Minsker, L.; Loeb, P.; ChemSusChem, 2014, 7, 3521-3533

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Ligand ordering determines the catalytic response of hybrid palladium nanoparticles in hydrogenation

Albani, D.; Vile, G.; Mitchell, S.; Witte, P. T.; Almora-Barrios, N.; Verel, R.; Lopez, N.; Perez-Ramirez, J.; Catal. Sci. Technol., 2016, 6(6), 1621-1631

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Lipase-catalyzed kinetic resolution of 2-methylene-substituted cycloalkanols in batch and continuous-flow modes

Tomin, A.; Hornyanszky, G.; Kupai, K.; Dorko, Zs.; Urge, L.; Darvas, F.; Poppe, L.; Process Biochemistry, 2010, 45(6), 859-865

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Lipase-catalyzed monostearin synthesis under continuous flow conditions

Junior, I. I.; Flores, M. C.; Sutili, F. K.; Leite, S. G. F.; Miranda, L. S. de M.; Leal, I. C. R.; de Souza, R. O. M. A.; Org. Process Res. Dev., 2012, 16(5), 1098-1101

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Liquid phase oxidation chemistry in continuous-flow microreactors

Gemoets, H. P. L.; Su, Y.; Shang, M.; Hessel V.; Luque, R.; Noel, T.; Chem. Soc. Rev., 2016, 45, 83-117

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Measurement of supramolecular effective molarities for intramolecular H-bonds in zinc porphyrin-imidazole complexes

Jinks, M. A.; Sun, H.; Hunter, C. A.; Org. Biomol. Chem., 2014, 12, 1440-1447

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Mechanistic insights into copper(I)‐catalyzed azide‐alkyne cycloadditions using continuous flow conditions

Fuchs, M.; Goessler, W.; Pilger, C.; Kappe, C. O.; Adv. Synth. Catal., 2010, 352, 323-328

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Merging single-atom-dispersed silver and carbon nitride to a joint electronic system via copolymerization with silver tricyanomethanide

Chen, Z.; Pronkin, S.; Fellinger, T. P.; Kailasam, K.; Vile, G.; Albani, D.; Krumeich, F.; Leary, R.; Barnard, J.; Thomas, J. M.; Perez-Ramirez, J.; Antonietti, M.; Dontsova, D.; ACS Nano, 2016, 10(3), 3166-3175

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Mesoscale flow chemistry: A plug-flow approach to reaction optimisation

Wheeler, R. C.; Benali, O.; Deal, M.; Farrant, E.; MacDonald, S. J. F.; Warrington, B. H.; Org. Process Res. Dev., 2007, 11, 704-710

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Metal-catalyzed amidation

Roy, S.; Roy, S.; Gribble, G. W.; Tetrahedron, 2012, 68, 9867-9923

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Metathesis reactions on solid-phase: Towards new synthesis challenges

Franzen, R. G.; Top Catal., 2016, 59, 1143-1150

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Methods for the synthesis of indole-3-carboxylic acid esters

Litvinova, V. A.; Tikhomirov, A. S.; Chemistry of Heterocyclic Compounds, 2018, 54, 923-925

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Methylation using dimethylcarbonate catalysed by ionic liquids under continuous flow conditions

Glasnov, T. N.; Holbrey, J. D.; Kappe, C. O.; Seddon, K. R.; Yan, T.; Green Chem., 2012, 14, 3071-3076

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Micro reactors, flow reactors and continuous flow synthesis

Watts, P.; Wiles, C.; Journal of Chemical Research, 2012, 36, 181-193

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Microfluidics in commercial applications; an industry perspective

Haber, C.; Lab Chip, 2006, 6, 1118-1121

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Microreactors for peptide synthesis: looking through the eyes of twenty first century !!!

Ramesh, S.; Cherkupally, P.; de la Torre, B. G.; Govender, T.; Kruger, H. G.; Albericio, F.; Amino Acids, 2014, 46, 2091-2104

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Microwave-assisted and continuous flow multistep synthesis of 4-(pyrazol-1-yl)carboxanilides

Obermayer, D.; Glasnov, T. N.; Kappe, C. O.; J. Org. Chem., 2011, 76(16), 6657-6669

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Microwave-assisted grafting to MCM-41 silica and its application as catalyst in flow chemistry

Oliverio, M.; Procopio, A.; Glasnov, T. N.; Goessler, W.; Kappe, C. O.; Aust. J. Chem., 2011, 64, 1522-1529

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Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters

Desai, B.; Dallinger, D.; Kappe, C. O.; Tetrahedron, 2006, 62, 4651-4664

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Microwave-assisted synthesis of medium-sized heterocycles

Sharma, A.; Appukkuttan, P.; Van der Eycken, E.; Chem. Commun., 2012, 48, 1623-1637

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Microwave chemistry enabling the synthesis of biologically relevant amines

Spencer, J.; Future Med. Chem., 2010, 2(2), 161-168

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Microwave heating and conventionally-heated continuous-flow processing as tools for performing cleaner palladium-catalyzed decarboxylative couplings using oxygen as the oxidant – a proof of principle study

Rudzinski, D. M.; Leadbeater, N. E.; Green Processing and Synthesis, 2013, 2(4), 323-328

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Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library

Spencer, J.; Patel, H.; Amin, J.; Callear, S. K.; Coles, S. J.; Deadman, J. J.; Furman, C.; Mansouri, R.; Chavatte, P.; Millet, R.; Tetrahedron Letters, 2012, 53, 1656-1659

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Mild and selective hydrogenation of nitro compounds using palladium nanoparticles supported on amino‐functionalized mesocellular foam

Verho, O.; Gustafson, K. P. J.; Nagendiran, A.; Tai, C.; Backvall, J.; ChemCatChem, 2014, 6(11), 3153-3159

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Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507

Scott, D. A.; Dakin, L. A.; Daly, K.; Del Valle, D. J.; Diebold, R. B.; Drew, L.; Ezhuthachan, J.; Gero, T. W.; Ogoe, C. A.; Omer, C. A.; Redmond, S. P.; Repik, G.; Thakur, K.; Ye, Q.; Zheng, X.; Bioorg. Med. Chem. Lett., 2013, 23, 4591-4596

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Modeling, synthesis and biological evaluation of potential retinoid X receptor‐selective agonists: Novel halogenated analogues of 4‐[1‐(3,5,5,8,8‐pentamethyl‐5,6,7,8‐tetrahydro‐2‐naphthyl)ethynyl]benzoic acid (Bexarotene)

Furmick, J. K.; Kaneko, I.; Walsh, A. N.; Yang, J.; Bhogal, J. S.; Gray, G. M.; Baso, J. C.; Browder, D. O., Prentice, J. L. S.; Montano, L. A.; Huynh, C. C.; Marcus, L. M.; Tsosie, D. G.; Kwon, J. S.; Quezada, A.; Reyes, N. M.; Lemming, B.; Saini, P.; van der Vaart, A.; Groy, T. L.; Marshall, P. A.; Jurutka, P. W.; Wagner, C. E.; ChemMedChem, 2012, 7, 1551-1566

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Molecularly imprinted hydrogels as functional active packaging materials

Benito-Pena, E.; Gonzalez-Vallejo, V.; Rico-Yuste, A.; Barbosa-Pereira, L.; Cruz, J. M.; Bilbao, A.; Alvarez-Lorenzo, C.; Moreno-Bondi, M. C.; Food Chemistry, 2016, 190, 487-494

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Molecularly imprinted polymers for cleanup and selective extraction of curcuminoids in medicinal herbal extracts

Wulandari, M.; Urraca, J. L.; Descalzo, A. B.; Amran, M. B.; Moreno-Bondi, M. C.; Analytical and Bioanalytical Chemistry, 2015, 407(3), 803-812

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Monitoring glycan-protein interactions by NMR spectroscopic analysis: A simple chemical tag that mimics natural CH–π interactions

Calle, L. P.; Echeverria, B.; Franconetti, A.; Serna, S.; Fernandez-Alonso, M. C.; Diercks, T.; Canada, F. J.; Arda, A.; Reichardt, N. C.; Jimenez-Barbero, J.; Chem. Eur. J., 2015, 21(32), 11408-11416

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Multi-step solvent-free 3 m2 footprint pilot miniplant for the synthesis of annual half ton rufinamide precursor

Gelonch, M. E.; de Leon Izeppi, G. A.; Kirschneck, D.; Hessel, V.; ACS Sustainable Chem. Eng., 2019, 7(20), 17237-17251

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Multigram-scale flow synthesis of the chiral key intermediate of (−)-paroxetine enabled by solvent-free heterogeneous organocatalysis

Otvos, S. B.; Pericas, M. A.; Kappe, C. O.; Chem. Sci., 2019, advance article

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Multistep continuous‐flow synthesis in medicinal chemistry: Discovery and preliminary structure-activity relationships of CCR8 ligands

Petersen, T. P.; Mirsharghi, S.; Rummel, P. C.; Thiele, S.; Rosenkilde, M. M.; Ritzen, A.; Ulven, T.; Chem. Eur. J., 2013, 19(28), 9343-9350

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Multistep continuous-flow synthesis of condensed benzothiazoles

Lovei, K.; Greiner, I.; Eles, J.; Szigetvari, A.; Dekany, M.; Levai, S.; Novak, Z.; Turos, I. Gy.; J. Flow Chem., 2015, 5(2), 74-81

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Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties as novel synthetic polyphenols directed against HIV-1

Flores, A.; Camarasa, M. J.; Perez-Perez, M. J.; San-Felix, A.; Balzarini, J.; Quesada, E.; Org. Biomol. Chem., 2014, 12, 5278-5294

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My twenty years in microwave chemistry: from kitchen ovens to microwaves that aren’t microwaves

Kappe, C. O.; Chem. Rec., 2019, 19(1), 15-39

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N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist

Boldron, C.; Besse, A.; Bordes, M.; Tissandie, S.; Yvon, X.; Gau, B.; Badorc, A.; Rousseaux, T.; Barre, G.; Meneyrol, J.; Zech, G.; Nazare, M.; Fossey, V.; Pflieger, A.; Bonnet-Lignon, S.; Millet, L.; Briot, C.; Dol, F.; Herault, J.; Savi, P.; Lassalle, G.; Delesque, N.; Herbert, J.; Bono, F.; J. Med. Chem., 2014, 57(17), 7293-7316

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Nafion‐H‐catalyzed high‐temperature/high‐pressure synthesis of a triarylmethane in continuous‐flow mode

Hayden, S.; Glasnov, T.; Kappe, C. O.; Chem. Eng. Technol., 2015, 38(10), 1743-1748

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Nanocatalysis in continuous flow: supported iron oxide nanoparticles for the heterogeneous aerobic oxidation of benzyl alcohol

Obermayer, D.; Balu, A. M.; Romero, A. A.; Goessler, W.; Luque, R.; Kappe, C. O.; Green Chem., 2013, 15, 1530-1537

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Nanocatalysis in flow

Ricciardi, R.; Huskens, J.; Verboom, W.; ChemSusChem, 2015, 8(16), 2586-2605

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Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow

Nagendiran, A.; Sorensen, H.; Johansson, M. J.; Tai, C-W.; Backvall, J-E.; Green Chem., 2016, 18(9), 2632-2637

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Nanoparticle synthesis completed with in situ catalyst preparation performed on a high-pressure high-temperature continuous flow reactor

Niesz, K.; Hornyak, I.; Borcsek, B.; Darvas, F.; Microfluidics and Nanofluidics, 2008, 5(3), 411-416

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Nanotechnology tools in pharmaceutical R&D

Kumar, C. S. S. R.; Materials Today, 2010, 12, 24-30

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Natural‐product‐like spiroketals and fused bicyclic acetals as potential therapeutic agents for B‐cell chronic lymphocytic leukaemia

Milroy, L-G.; Zinzalla, G.; Loiseau, F.; Qian, Z.; Prencipe, G.; Pepper, C.; Fegan, C.; Ley, S. V.; ChemMedChem, 2008, 3, 1922-1935

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Natural product synthesis on the fly – multistep continuous reaction shows the power of automated flow synthesis

Ritter, S. K.; Chemical & Engineering News, 2006, 84(10), 17

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New copper-containing catalysts based on modified amorphous silica and their use in flow azide—alkyne cycloaddition

Burilov, V. A.; Nurmukhametova, A. N.; Belov, R. N.; Mironova, D. A.; Vorob'ev, V. V.; Osin, Yu. N.; Antipin, I. S.; Russian Chemical Bulletin Int. Ed., 2018, 67, 461-468

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New data in the enantioselective hydrogenation of ethyl pyruvate on Pt-cinchona chiral catalyst using continuous-flow fixed-bed reactor system: The origin of rate enhancement

Szollosi, Gy.; Cserenyi, Sz.; Balazsik, K.; Fulop, F.; Bartok, M.; Journal of Molecular Catalysis A: Chemical, 2009, 305, 155-160

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New data on the Orito reaction: Effect of substrate structure on nonlinear phenomenon

Balazsik, K.; Cserenyi, S.; Szollosi, G.; Fulop, F.; Bartok, M.; Catal. Lett., 2008, 125, 401-407

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New data to the origin of rate enhancement on the Pt-cinchona catalyzed enantioselective hydrogenation of activated ketones

Szollosi, G.; Cserenyi, S.; Fulop, F.; Bartok, M.; Journal of Catalysis, 2008, 260(2), 245-253

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New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics

Pilkington-Miksa, M.; Araldi, E. M.; Arosio, D.; Belvisi, L.; Civera, M.; Manzoni, L.; Org. Biomol. Chem., 2016, 14(12), 3221-3233.

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Nickel-catalyzed reductive [2+2] cycloaddition of alkynes

Canellas, S.; Montgomery, J.; Pericas, M. A.; J. Am. Chem. Soc., 2018, 140(50), 17349-17355

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Nitro lignin-derived nitrogen-doped carbon as an efficient and sustainable electrocatalyst for oxygen reduction

Graglia, M.; Pampel, J.; Hantke, T.; Fellinger, T. P.; Esposito D.; ACS Nano, 2016, 10(4), 4364-4371

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Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis

Jarrad, A. M.; Debnath, A.; Miyamoto, Y.; Hansford, K. A.; Pelington, R.; Butler, M. S.; Bains, T.; Karoli, T.; Blaskovich, M. A. T.; Eckmann, L.; Cooper, M. A.; Eur. J. Med. Chem., 2016, 120, 353-362

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Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

Gauthier, C.; Chassagne, P.; Theillet, F. X.; Guerreiro, C.; Thouron, F.; Nato, F.; Delepierre, M.; Sansonetti, P. J.; Phalipon, A.; Mulard, L. A.; Org. Biomol. Chem., 2014, 12, 4218-4232

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Novel biorefinery concept via Achmatowicz rearrangement, synthesis of pentane‐1,2,5‐triol from furfuryl alcohol

Simeonov, S. P.; Ravutsov, M. A.; Mihovilovic, M. D.; ChemSusChem, 2019, 12(12), 2748-2754

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Novel derivatives of usnic acid effectively inhibiting reproduction of influenza A virus

Shtro, A. A.; Zarubaev, V. V.; Luzina, O. A.; Sokolov, D. N.; Kiselev, O. I.; Salakhutdinov, N. F.; Bioorg. Med. Chem., 2014, 22(24), 6826-6836

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Novel evidence on the role of the nucleophilic intermediate complex in the Orito-reaction: Unexpected inversion in the enantioselective hydrogenation of 2,2,2-trifluoroacetophenone on Pt-cinchona chiral catalyst using continuous-flow fixed-bed reactor

Szollosi, G.; Cserenyi, S.; Bartok, M.; Catal. Lett., 2010, 134, 264-269

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Novel phosphine-phosphites and their use in asymmetric hydrogenation

Farkas, G.; Balogh, S.; Szollosy, A.; Urge, L.; Darvas, F.; Bakos, J.; Tetrahedron: Asymmetry, 2011, 22(24), 2104-2109

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Novel process windows for enabling, accelerating and uplifting flow chemistry

Hessel, V.; Kralisch, D.; Kockmann, N.; Noel, T.; Wang, Q.; ChemSusChem, 2013, 6(5), 746-789

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Novel spirotetracyclic zwitterionic dual H1/5-HT2A receptor antagonists for the treatment of sleep disorders

Gianotti, M.; Botta, M.; Brough, S.; Carletti, R.; Castiglioni, E.; Corti, C.; Dal-Cin, M.; Fratte, S. D.; Korajec, D.; Lovric, M.; Merlo, G.; Mesic, M.; Pavone, F.; Piccoli, L.; Rast, S.; Roscic, M.; Sava, A.; Smehil, M.; Stasi, L.; Togninelli, A.; Wigglesworth, M. J.; J. Med. Chem., 2010, 53, 7778-7795

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Nucleophilic aromatic substitution of heterocycles using a high-temperature and high-pressure flow reactor

Charaschanya, M.; Bogdan, A. R.; Wang, Y.; Djuric, S. W.; Tetrahedron Letters, 2016, 57(9), 1035-1039

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Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1

Manka, J. T.; Rodriguez, A. L.; Morrison, R. D.; Venable, D. F.; Cho, H. P.; Blobaum, A. L.; Daniels, J. S.; Niswender, C. M.; Conn, P. J.; Lindsley, C. W.; Emmitte, K. A.; Bioorg. Med. Chem. Lett., 2013, 23(18), 5091-5096

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One-pot reductive amination of aldehydes with nitroarenes over an Au/Al2O3 catalyst in a continuous flow reactor

Artiukha, E. A.; Nuzhdin, A. L.; Bukhtiyarova, G. A.; Zaytsev, S. Yu.; Plyusnin, P. E.; Shubinbc, Yu. V.; Bukhtiyarov, V. I.; Cat. Sci. Technol., 2015, 5(10), 4741-4745

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One-pot synthesis of secondary amines from nitroarenes and aldehydes on supported copper catalysts in a flow reactor: The effect of the support

Artyukha, E. A.; Nuzhdin, A. L.; Bukhtiyarova, G. A.; Derevyannikova, E. A.; Gerasimov, E. Yu.; Gladkii, A. Yu.; Bukhtiyarov, V. I.; Kinetics and Catalysis, 2018, 59(5), 593-600

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Online monitoring and analysis for autonomous continuous flow self-optimizing reactor systems

Fabry, D. C.; Sugiono, E.; Rueping M.; React. Chem. Eng., 2016, 1, 129-133

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Optically pure, structural, and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach

Liu, M.; Mountford, S. J.; Richardson, R. R.; Groenen, M.; Holliday, N. D.; Thompson, P. E.; J. Med. Chem., 2016, 59(13), 6059-6069

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Optimisation of conditions for O‐benzyl and N‐benzyloxycarbonyl protecting group removal using an automated flow hydrogenator

Knudsen, K. R.; Holden, J.; Ley, S. V.; Ladlow, M.; Adv. Synth. Catal., 2007, 349, 535-538

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Optimization of novel indazoles as highly potent and selective inhibitors of phosphoinositide 3-kinase δ for the treatment of respiratory disease

Down, K.; Amour, A.; Baldwin, I. R.; Cooper, A. W. J.; Deakin, A. M.; Felton, L. M.; Guntrip, S. B.; Hardy, C.; Harrison, Z. A.; Jones, K. L.; Jones, P.; Keeling, S. E.; Le, J.; Livia, S.; Lucas, F.; Lunniss, C. J.; Parr, N. J.; Robinson, E.; Rowland, P.; Smith, S.; Thomas, D. A.; Vitulli, G.; Washio, Y.; Hamblin, J. N.; J. Med. Chem., 2015, 58(18), 7381-7399

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Organic synthesis: March of the machines

Ley, S. V.; Fitzpatrick, D. E.; Ingham, R. J.; Myers, R. M.; Angewandte Chemie Int. Ed., 2015, 54(11), 3449-3464

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Origin of problems related to Staudinger reduction in carbopeptoid syntheses

Csordas, B.; Nagy, A.; Harmat, V.; Zsoldos-Mady, V.; Leveles, I.; Pinter, I.; Farkas, V.; Perczel, A.; Amino Acids, 2016, 48(11), 2619-2633

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Origin of the rate enhancement and enantiodifferentiation in the heterogeneous enantioselective hydrogenation of 2,2,2-trifluoroacetophenone over Pt/alumina studied in continuous-flow fixed-bed reactor system

Szollosi, Gy.; Cserenyi, Sz.; Bucsi, I.; Bartok, T.; Fulop, F.; Bartok, M.; Applied Catalysis A: General, 2010, 382, 263-271

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Oxazolomycins: Natural product lead structures for novel antibacterials by click fragment conjugation

Bagwell, C. L.; Moloney, M. G.; Yaqoob, M.; Bioorg. Med. Chem. Lett., 2010, 20(7), 2090-2094

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p-Nitrophenol flow hydrogenation with nano-Cu2O grafted on polymeric resin

Paun, C.; Gizinski, D.; Zienkiewicz-Machnik, M.; Banas, D.; Kubala-Kukus, A.; Sa, J.; Catalysis Communications, 2017, 92, 61-64

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Palladium on carbon-catalyzed Suzuki-Miyaura coupling reaction using an efficient and continuous flow system

Hattori, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Catalysts, 2015, 5, 18-25

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Papain‐specific activating esters in aqueous dipeptide synthesis

de Beer, R. J. A. C.; Zarzycka, B.; Mariman, M.; Amatdjais-Groenen, H. I. V.; Mulders, M. J.; Quaedflieg, P. J. L. M.; van Delft, F. L.; Nabuurs, S. B.; Rutjes, F. P. J. T.; ChemBioChem, 2012, 13(9), 1319-1326

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Parallel synthesis of 1,2,4-triazole derivatives using microwave and continuous-flow techniques

Szommer T.; Lukacs A.; Kovacs J.; Szabo, M. J.; Hoffmann M. G.; Schmitt M. H.; Gerencser J.; Mol. Divers., 2012, 16(1), 81-90

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Pd-P nanoalloys supported on porous carbon frame as efficient catalyst for benzyl alcohol oxidation

Guo, W.; Niu, S.; Shi, W.; Zhang, B.; Yu, W.; Xie, Y.; Ji, X.; Wu, Y.; Su, D.; Shao, L.; Catal. Sci. Technol., 2018, 8, 2333-2339

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Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor

Salamoun, J. M.; McQueeney, K. E.; Patil, K.; Geib, S. J.; Sharlow, E. R.; Lazo, J. S.; Wipf, P.; Org. Biomol. Chem., 2016, 14(27), 6398-6402

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Polysaccharides from Burkholderia species as targets for vaccine development, immunomodulation and chemical synthesis

Cloutier, M.; Muru, K.; Ravicoularamin, G.; Gauthier, C.; Nat. Prod. Rep., 2018, 35, 1251-1293

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Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure–activity relationship (SAR) studies

Nuzzi, A.; Fiasella, A.; Ortega, J. A.; Pagliuca, C.; Ponzano, S.; Pizzirani, D.; Bertozzi, S. M.; Ottonello, G.; Tarozzo, G.; Reggiani, A.; Bandiera, T.; Bertozzi, F.; Piomelli, D.; Eur. J. Med. Chem., 2016, 111, 138-159

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Practical synthesis of (S)-pyrrolidin-2-yl-1H-tetrazole, incorporating efficient protecting group removal by flow-reactor hydrogenolysis

Franckevicius, V.; Knudsen, K. R.; Ladlow, M.; Longbottom, D. A.; Ley, S. V.; Synlett, 2006, 6, 889-892

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Preclinical characterization of the FAAH inhibitor JNJ-42165279

Keith, J. M.; Jones, W. M.; Tichenor, M.; Liu, J.; Seierstad, M.; Palmer, J. A.; Webb, M.; Karbarz, M.; Scott, B. P.; Wilson, S. J.; Luo, L.; Wennerholm, M. L.; Chang, L.; Rizzolio, M.; Rynberg, R.; Chaplan, S. R.; Breitenbucher, J. G.; ACS Med. Chem. Lett., 2015, 6(12), 1204-1208

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Preparation of HKUST-1@silica aerogel composite for continuous flow catalysis

Shalygin, A. S.; Nuzhdin, A. L.; Bukhtiyarova, G. A.; Martyanov, O. N.; J. Sol-Gel Sci. Technol., 2017, 84(3), 446-452

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Preparation of vinyl ethers using a Wittig approach, and their subsequent hydrogenation employing continuous-flow processing

Balti, M.; Efrit, M. L.; Leadbeater, N. E.; Tetrahedron Lett., 2016, 57, 1804-1806

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Present and future of cyclopropanations in fragrance chemistry

Schroder, F.; Chem. Biodivers., 2014, 11(11), 1734-1751

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Process development of a potent glucosylceramide synthase inhibitor

Cooper, C. G. F.; Lee, E. R.; Silva, R. A.; Bourque, A. J.; Clark, S.; Katti, S.; Nivorozkhin, V.; Org. Process Res. Dev., 2012, 16(5), 1090-1097

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Process intensification for the continuous flow hydrogenation of ethyl nicotinate

Ouchi, T.; Battilocchio, C.; Hawkins, J. M.; Ley, S. V.; Org. Process Res. Dev., 2014, 18(11), 1560-1566

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Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors

George, D. M.; Huntley, R. J.; Cusack, K.; Duignan, D. B.; Hoemann, M.; Loud, J.; Mario, R.; Melim, T.; Mullen, K.; Somal, G.; Wang, L.; Edmunds, J. J.; PlosOne, 2018, online article

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Pt-cinchonidine catalyzed asymmetric catalytic cascade reaction of 2-nitrophenylpyruvates in flow system

Kovacs, L.; Szollosi, Gy.; Fulop, F.; J. Flow Chem., 2015, 5(4), 210-215

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Pyrido[2,3-d]pyrimidin-5-ones: A novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors

Huang, H.; Hutta, D. A.; Rinker, J. M.; Hu, H.; Parsons, W. H.; Schubert, C.; DesJarlais, R. L.; Crysler, C. S.; Chaikin, M. A.; Donatelli, R. R.; Chen, Y.; Cheng, D.; Zhou, Z.; Yurkow, E.; Manthey, C. L.; Player, M. R.; J. Med. Chem., 2009, 52(4), 1081-1099

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Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform

Desai, B.; Dixon, K.; Farrant, E.; Feng, Q.; Gibson, K. R.; van Hoorn, W. P.; Mills, J.; Morgan, T.; Parry, D. M.; Ramjee, M. K.; Selway, C. N.; Tarver, G. J.; Whitlock, G.; Wright, A. G.; J. Med. Chem., 2013, 56(7), 3033-3047

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Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

Liang, S. H.; Collier, T. L.; Rotstein, B. H.; Lewis, R.; Steck, M.; Vasdev, N.; Chem. Commun., 2013, 49(78), 8755-8757

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Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry

Ekholm, F. S.; Mandity, I. M.; Fulop, F.; Leino, R.; Tetrahedron Lett., 2011, 52, 1839-1841

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Rapid synthesis of substituted pyrrolines and pyrrolidines by nucleophilic ring closure at activated oximes

Chandan, N.; Thompson, A. L.; Moloney, M. G.; Org. Biomol. Chem., 2012, 10, 7863-7868

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Reaction screening in continuous flow reactors

Mohamed, D. K. B.; Yu, X.; Li, J.; Wu, J.; Reaction screening in continuous flow reactors; Tetrahedron Lett., 2016, 57, 3965-3977.

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ReactIR flow cell: a new analytical tool for continuous flow chemical processing

Carter, C. F.; Lange, H.; Ley, S. V.; Baxendale, I. R.; Wittkamp, B.; Goode, J. G.; Gaunt, N. L.; Org. Process Res. Dev., 2010, 14, 393-404

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Reagent-controlled stereoselective synthesis of (±)-gallo- and (±)-epigallo-catechin gallates

Tanaka, H.; Chino, A.; Takahashi, T.; Tetrahedron Letters, 2012, 53, 2493-2495

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Rearrangement of N-alkyl 1,2-amino alcohols. Synthesis of (S)-toliprolol and (S)-propanolol

Duthion, B.; Metro, T.; Padro, D. G.; Cossy, J.; Tetrahedron, 2009, 65(33), 6696-6706

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Recent advances for serial processes of hazardous chemicals in fully integrated microfluidic systems

Singh, R.; Lee, H. J.; Singh, A. K.; Kim, D. P.; Korean Journal of Chemical Engineering, 2016, 33(8), 2253-2267

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Recent advances in asymmetric catalysis in flow

Zhao, D.; Ding, K.; ACS Catal., 2013, 3(5), 928-944

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Recent advances in micro reaction technology

Wiles, C.; Watts, P.; Chemical Communications, 2011, 47(23), 6512-6535

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Reconstruction of humins formation mechanism from decomposition products: A GC-MS study based on catalytic continuous flow depolymerizations

Filiciotto, L.; M. Balu, A.; Romero, A. A.; Angelici, C.; van der Waal, J. C.; Luque, R.; Mol. Cat., 2019, 479, 110564

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Recycling the waste: the development of a catalytic Wittig reaction

O'Brien, C. J.; Tellez, J. L.; Nixon, Z. S.; Kang, L. J.; Carter, A. L.; Kunkel, S. R.; Przeworski, K. C.; Chass, G. A.; Angew. Chem. Int. Ed., 2009, 48(37), 6836-6839

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Reductive amination in the synthesis of pharmaceuticals

Afanasyev, O. I.; Kuchuk, E.; Usanov, D. L.; Chusov, D.; Chem. Rev., 2019, accepted manuscript

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Reductive amination by continuous-flow hydrogenation: direct and scalable synthesis of a benzylpiperazine

Liu, J.; Fitzgerald, A. E.; Mani, N. S.; Synthesis, 2012, 44(15), 2469-2473

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Reductive amination of ketones: novel one-step transfer hydrogenations in batch and continuous-flow mode

Falus, P.; Boros, Z.; Hornyanszky, G.; Nagy, J.; Darvas, F.; Urge, L.; Poppe, L.; Tetrahedron Letters, 2011, 52, 1310-1312

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Regio-, diastereo-, and enantioselective nitroso-Diels–Alder reaction of 1,3-diene-1-carbamates catalyzed by chiral phosphoric acids

Pous, J.; Courant, T.; Bernadat, G.; Iorga, B. I.; Blanchard, F.; Masson, G.; J. Am. Chem. Soc., 2015, 137(37), 11950-11953

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Regioselective catalytic alkylation of N-heterocycles in continuous flow

Sipocz, T.; Lengyel., L.; Sipos, G.; Kocsis, L.; Dorman, Gy.; Jones, R. V.; Darvas, F.; J. Flow Chem., 2016, 6(2), 117-122

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Reissert indole synthesis using continuous-flow hydrogenation

Colombo, E.; Ratel, P.; Mounier, L.; Guillier, F.; J. Flow Chem., 2011, 2, 68-73

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Research spotlight: Microwave chemistry enabling the synthesis of biologically relevant amines

Spencer, J.; Future Med. Chem, 2010, 2(2), 161-168

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Reversal of the ee in enantioselective hydrogenation of activated ketones in continuous-flow fixed-bed reactor system

Cserenyi, Sz.; Szollosi, Gy.; Szori, K.; Fulop, F.; Bartok, M.; Catalysis Communications, 2010, 12, 14-19

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Reversible and efficient inhibition of UDP‐galactopyranose mutase by electrophilic, constrained and unsaturated UDP‐galactitol analogues

Ansiaux, C.; N'Go, I.; Vincent, S. P.; Chem. Eur. J., 2012, 18(46), 14860-14866

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Revisiting the deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions

Tshibalonza, N. N.; Monbaliu, J-C. M.; Green Chem., 2017, 19, 3006-3013

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Ruthenium and osmium complexes of novel carbohydrate derived salen ligands: Synthesis, characterization and in situ ligand reduction

Mandal, S.; Mandal, S.; Seth, D. K.; Mukhopadhyay, B.; Gupta, P.; Inorganica Chimica Acta, 2013, 398, 83-88

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Safe generation and synthetic utilization of hydrazoic acid in a continuous flow reactor

Gutmann, B.; Obermayer, D.; Roduit, J. P.; Roberge, D. M.; Kappe, C. O.; J. Flow Chem., 2012, 2(1), 8-19

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Safe hydrogenation of organic compounds and their property studies

Soung, M. J.; Woo, S. J.; Shin, D. J.; APEC Youth Scientist Journal, 2015, 7(1), 45-53

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Structure-activity relationship studies of mitogen activated protein kinase interacting kinase (MNK) 1 and 2 and BCR-ABL1 inhibitors targeting chronic myeloid leukemic cells

Cherian, J.; Nacro, K.; Poh, Z. Y.; Guo, S.; Jeyaray, D. A.; Wong, Y. X.; Ho, M.; Yang, H. Y.; Joy, J. K.; Kwek, Z. P.; Liu, B.; Wee, J. L. K.; Ong, E. H.; Choong, M. L.; Poulsen, A.; Lee, M. A.; Pendharkar, V.; Ding, L. J.; Manoharan, V.; Chew, Y. S.; Sangthongpitag, K.; Lim, S.; Ong, S. T.; Hill, J.; Keller, T. H.; J. Med. Chem., 2016, 59(7), 3063-3078

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SBA materials as support of iridium catalyst for hydrogenation reactions

Kiderys, A.; Kot, M.; Janiszewska, E.; Pietrowski, M.; Yang, C-M.; Zielinski, M.; Catalysis Today, 2019, accepted manuscript

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Scalable and straightforward synthesis of all isomeric (cyclo)alkylpiperidines

Subota, A. I.; Lutsenko, A. O.; Vashchenko, B. V.; Volochnyuk, D. M.; Levchenko, V.; Dmytriv, Y. V.; Rusanov, E. B.; Gorlova, A. O.; Ryabukhin, S. V.; Grygorenko, O. O.; Eur. J. Org. Chem., 2019, 2019(22), 3636-3648

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Scalable synthesis of an integrin-binding peptide mimetic for biomedical applications

Riches, A. G.; Cablewski, T.; Glattauer, V.; Thissen, H.; Meagher, L.; Tetrahedron, 2012, 68(46), 9448-9455

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Scale-up of flow-assisted synthesis of C2-symmetric chiral PyBox ligands

Battilocchio, C.; Baumann, M.; Baxendale, I. R.; Biava, M.; Kitching, M. O.; Ley, S. V.; Martin, R. E.; Ohnmacht, S. A.; Tappin, N. D. C.; Synthesis, 2012, 4, 635-647

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Scale-up synthesis of a deuterium-labeled cis-cyclobutane-1,3-dicarboxylic acid derivative using continuous photo flow chemistry

Yamashita, T.; Nishikawa, H.; Kawamoto, T.; Tetrahedron, 2019, 75(5), 617-623

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Scaling up and validation of hydrogenation reactions using a continuous-flow microfluidics-based reactor, H-Cube®

Spadoni, C; Jones, R. V.; Urge, L.; Darvas, F.; Chemistry Today, 2006, January/February 2006, 38-41

Selective catalytic hydrogenations in a microfluidics-based high throughput flow reactor on ion-exchange supported transition metal complexes: A modular approach to the heterogenization of soluble complex catalysts

Horvath, H. H.; Papp, G.; Csajagi, Cs.; Joo, F.; Cat. Commun., 2007, 8, 442-446

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Selective ensembles in supported palladium sulfide nanoparticles for alkyne semi-hydrogenation

Albani, D.; Shahrokhi, M.; Chen, Z.; Mitchell, S.; Hauert, R.; Lopez, N.; Perez-Ramirez, J.; Nature Communications, 2018, 9, article number: 2634

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Selective liquid‐phase hydrogenation of a nitro group in substituted nitrobenzenes over Au/Al2O3 catalyst in a packed‐bed flow reactor

Nuzhdin, A. L.; Moroz, B. L.; Bukhtiyarova, G. A.; Reshetnikov, S. I.; Pyrjaev, P. A.; Aleksandrov P. V.; Bukhtiyarov, V. I.; ChemPlusChem, 2015, 80(12), 1741-1749

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Self-assembly of a helical zinc-europium complex: speciation in aqueous solution and luminescence

Deiters, E.; Eliseeva, S. V.; Bunzli, J. C. G.; Front. Chem., 2013, 1(15), 1-14

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Self-optimizing reactor systems: Algorithms, on‐line analytics, setups, and strategies for accelerating continuous flow process optimization

Fabry, D. C.; Sugiono, E.; Ruepig, M.; Isr. J. Chem., 2014, 54(4), 341-350

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Sequential nitration/hydrogenation protocol for the synthesis of triaminophloroglucinol: Safe generation and use of an explosive intermediate under continuous-flow conditions

Cantillo, D.; Damm, M.; Dallinger, D.; Bauser, M.; Berger, M.; Kappe, C. O.; Org. Process Res. Dev., 2014, 18(11), 1360-1366

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SiliaCat: A versatile catalyst series for synthetic organic chemistry

Ciriminna, R.; Pandarus, V.; Fidalgo, A.; Ilharco, L. M.; Beland, F.; Pagliaro, M.; Org. Process Res. Dev., 2015, 19(7), 755-768

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Single-atom heterogeneous catalysts based on distinct carbon nitride scaffolds

Chen, Z.; Vorobyeva, E.; Mitchell, S.; Fako, E.; Lopez, N.; Collins, S. M.; Leary, R. K.; Midgley, P. A.; Hauert, R.; Perez-Ramirez, J.; National Science Review, 2018, 5(5), 642-652

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Single operation stereoselective synthesis of Aerangis lactones: Combining continuous flow hydrogenation and biocatalysts in a chemoenzymatic sequence

Fink, M. J.; Schon, M.; Rudroff, F.; Schnurch, M.; Mihovilovic, M. D.; ChemCatChem, 2013, 5, 724-727

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Site‐selective deuterated‐alkene synthesis with palladium on boron nitride

Yabe, Y.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Chem. Eur. J., 2013, 19, 484-488

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Solvent-free continuous operations using small footprint reactors: A key approach for process intensification

Ouchi, T.; Mutton, R. J.; Rojas, V.; Fitzpatrick, D. E.; Cork, D. G.; Battilocchio, C.; Ley, S. V.; ACS Sustainable Chem. Eng., 2016, 4, 1912-1916

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Solvent-free enzymatic process for biolubricant production in continuous microfluidic reactor

Madarasz, J.; Nemeth, D.; Bakos, J.; Gubicza, L.; Bakonyi, P.; Journal of Cleaner Production, 2015, 93, 140-144

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Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control

Voltrova, S.; Srogl, J.; Org. Chem. Front., 2014, 1, 1067-1071

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Spirocyclic dihydropyridines by electrophile-induced dearomatizing cyclization of N-alkenyl pyridinecarboxamides

Senczyszyn, J.; Brice, H.; Clayden, J.; Org. Lett., 2013, 15(8), 1922-1925

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Stepwise aromatic nucleophilic substitution in continuous flow. Synthesis of an unsymmetrically substituted 3,5-diamino-benzonitrile library

Lengyel, L.; Gyollai, V.; Nagy, T.; Dorman, G.; Terleczky, P.; Hada, V.; Nogradi, K.; Sebok, F.; Urge, L.; Darvas, F.; Mol. Divers., 2011, 15(3), 631-638

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Stereo‐ and chemoselective character of supported CeO2 catalysts for continuous‐flow three‐phase alkyne hydrogenation

Vile, G.; Wrabetz, S.; Floryan, L.; Schuster, M. E.; Girgsdies, F.; Teschner, D.; Perez-Ramirez, J.; ChemCatChem, 2014, 6(7), 1928-1934

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Stereocontrolled synthesis of the cis‐hydroxydecalin system: Towards biologically active 19‐nor‐clerodanes

Mirzayans, P. M.; Pouwer, R. H.; Williams, C. M.; Bernhardt, P. V.; Eur. J. Org. Chem., 2012, 2012(8), 1633-1638

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Stereoselective approaches to 2,3,6-trisubstituted piperidines. An enantiospecific synthesis of quinolizidine (−)-217A

Mancey, N. C.; Sandon, N.; Auvinet, A. L.; Butlin, R. J.; Czechtizky, W.; Harrity, J. P. A.; Chem. Commun., 2011, 47(35), 9804-9806

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Stereoselective catalytic synthesis of active pharmaceutical ingredients in homemade 3D‐printed mesoreactors

Rossi, S.; Porta, R.; Brenna, D.; Puglisi, A.; Benaglia, M.; Angew. Chem. Int. Ed., 2017, 56(15), 4290-4294

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Stereoselective metal‐free reduction of chiral imines in batch and flow mode: a convenient strategy for the synthesis of chiral active pharmaceutical ingredients

Brenna, D.; Benaglia, M.; Porta, R.; Fernandes, S.; Burke, A. J.; Eur. J. Org. Chem., 2017, 2017(1), 39-44

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Stereoselective reduction of prochiral cyclic 1,3-diketones using different biocatalysts

Contente, M. L.; Dall’Oglio, F.; Annunziata, F.; Molinari, F.; Rabuffetti, M.; Romano, D.; Tamborini, L.; Rother, D.; Pinto, A.; Catalysis Letters, 2019, accepted manuscript

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Stereoselective syntheses and transformations of chiral 1,3-aminoalcohols and 1,3-diols derived from nopinone

Szakonyi, Zs.; Gonda, T.; Otvos, S. B.; Fulop, F.; Tetrahedron: Asymmetry, 2014, 25, 1138-1145

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Stereoselective total synthesis of the marine macrolide sanctolide A

Yadav, J. S.; Suresh, B.; Srihari, P.; Eur. J. Org. Chem., 2015, 2015(26), 5856-5863

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Straightforward hetero Diels-Alder reactions of nitroso dienophiles by microreactor technology

Monbaliu, J-C. M. R.; Cukalovic, A.; Marchand-Brynaert, J.; Stevens, C. V.; Tetrahedron Letters, 2010, 51, 5830-5833

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Structural identification of petroleum acids by conversion to hydrocarbons and multidimensional gas chromatography-mass spectrometry

Wilde, M. J.; Rowland S. J.; Analytical Chemistry, 2015, 87(16), 8457-8465

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Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives

Bazin, H. G.; Li, Y.; Khalaf, J. K.; Mwakwari, S.; Livesay, M. T.; Evans, J. T.; Johnson, D. A.; Bioorg. Med. Chem. Lett., 2015, 25(6), 1318-1323

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Structural studies of the O-acetyl-containing O-antigen from a Shigella flexneri serotype 6 strain and synthesis of oligosaccharide fragments thereof

Chassagne, P.; Fontana, C.; Guerreiro, C.; Gauthier, C.; Phalipon, A; Widmalm, G.; Mulard, L. A.; Eur. J. Org. Chem., 2013, 2013(19), 4085-4106

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Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents

Ng, P. S.; Manjunatha, U. H.; Rao, S. P. S.; Camacho, L. R.; Ma, N. L.; Herve, M.; Noble, C. G.; Goh, A.; Peukert, S.; Diagana, T. T.; Smith, P. W.; Kondreddi, R. R.; Eur. J. Med. Chem., 2015, 106, 144-156

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Structure and reactivity of supported hybrid platinum nanoparticles for the flow hydrogenation of functionalized nitroaromatics

Vile, G.; Almora-Barrios, N.; Lopez, N.; Perez-Ramirez, J.; ACS Catal., 2015, 5(6), 3767-3778

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Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase

Nichols, D. A.; Jaishankar, P.; Larson, W.; Smith, E.; Liu, G.; Beyrouthy, R.; Bonnet, R.; Renslo, A. R.; Chen, Y.; J. Med. Chem., 2012, 55(5), 2163-2172

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Structure-based optimization of naphthyridones into potent ATAD2 bromodomain inhibitors

Bamborough, P.; Chung, C.; Furze, R. C.; Grandi, P.; Michon, A.; Sheppard, R. J.; Barnett, H.; Diallo, H.; Dixon, D. P.; Douault, C.; Jones, E. J.; Karamshi, B.; Mitchell, D. J.; Prinjha, R. K.; Rau, C.; Watson, R. J.; Werner, T.; Demont, E. H.; J. Med. Chem., 2015, 58(15), 6151-6178

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Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential

Coteron, J. M.; Marco, M.; Esquivias, J.; Deng, X.; White, K. L; White, J.; Koltun, M.; Mazouni, F. E.; Kokkonda, S.; Katneni, K.; Bhamidipati, R.; Shackleford, D. M.; Angulo-Barturen, I.; Ferrer, S. B.; Jimenez-Diaz, M. B.; Gamo, F. J.; Goldasmith, E. J.; Charman, W. N.; Bathurst, I.; Floyd, D.; Matthews, D.; Burrows, J. N.; Rathod, P. K.; Charman, S. A.; Philips, M. A; J. Med. Chem., 2011, 54(15), 5540-5561

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Structuring hybrid palladium nanoparticles in metallic monolithic reactors for continuous-flow three-phase alkyne hydrogenation

Albani, D.; Vile, G.; Toro, M. A. B.; Kaufmann, R.; Mitchell, S.; Perez-Ramirez, J.; React. Chem. Eng., 2016, 1, 454-462

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Studies of long chain lipids in insects by high temperature gas chromatography and high temperature gas chromatography–mass spectrometry

Sutton, P. A.; Wilde, M. J.; Martin, S. J.; Cvacka, J.; Vrkoslav, V.; Rowland, S. J.; Journal of Chromatography A, 2013, 1297, 236-240

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Studies on the continuous-flow synthesis of nonpeptidal bis-tetrahydrofuran moiety of Darunavir

Leao, R. A. C.; Lopes, R. de O.; de M. Bezerra, M. A.; Muniz, M. N.; Casanova, B. B.; Gnoatto, S. C. B.; Gosmann, G.; Kocsis, L.; de Souza, R. O. M. A.; de M. Miranda, L. S.; Journal of Flow Chemistry, 2015, 5(4), 216-219

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Studies on the synthesis of the lasubine alkaloids

Aslam, N. F. M.; Simon, O.; Bates, R. W.; Tetrahedron, 2018, 74(38), 5032-5039

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Substrate engineering: Effects of different N-protecting groups in the CAL-B-catalysed asymmetric O-acylation of 1-hydroxymethyl-tetrahydro-β-carbolines

Megyesi, R.; Forro, E.; Fulop, F.; Tetrahedron, 2018, 74(21), 2634-2640

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Synergistic interaction within bifunctional ruthenium nanoparticle/SILP catalysts for the selective hydrodeoxygenation of phenols

Luska, K. L.; Migowski, P.; El Sayed, S.; Leitner, W.; Angew. Chem., 2015, 127(52), 15976-15981

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Syntheses of 4-, 5-, 6-, and 7-substituted tryptamine derivatives and the use of a bromine atom as a protecting group

Rene, O.; Fauber, B. P.; Tetrahedron Letters, 2014, 55(4), 830-833

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Syntheses of four enantiomers of 2,3-diendo- and 3-endo-aminobicyclo[2.2.2]oct-5-ene-2-exo-carboxylic acid and their saturated analogues

Palko, M.; Hanninen, M. M.; Sillanpaa, R.; Fulop, F.; Molecules, 2013, 18(12), 15080-15093

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Synthesis and activity of putative small-molecule inhibitors of the F-Box protein SKP2

Shouksmith, A. E.; Evans, L. E.; Tweddle, D. A.; Miller, D. C.; Willmore, E.; Newell, D. R.; Golding, B. T.; Griffin, R. J.; Aust. J. Chem., 2015, 68(4), 660-679

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Synthesis and anticancer activity of a series of norcantharidin analogues

Tarleton, M.; Gilbert, J.; Sakoff, J. A.; McCluskey, A.; Eur. J. Med. Chem., 2012, 54, 573-581

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Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease

Alexandre, F-R.; Brandt, G.; Caillet, C.; Chaves, D.; Convard, T.; Derock, M.; Gloux, D.; Griffon, Y.; Lallos, L.; Leroy, F.; Liuzzi, M.; Loi, A-G.; Moulat, L.; Musiu, C.; Parsy, C.; Rahali, H.; Roques, V.; Seifer, M.; Standring, D.; Surleraux, D.; Bioorg. Med. Chem. Lett., 2015, 25(18), 3984-3991

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Synthesis and arylation of unprotected sulfonimidamides

Maldonado; M. F.; Sehgelmeble, F.; Bjarnemark, F.; Svensson, M.; Ahman, F.; Arvidsson, P. I.; Tetrahedron, 2012, 68, 7456-7462

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Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins

McCarthy, A. R.; Pirrie, L.; Hollick, J. J.; Ronseaux, S.; Campbell, J.; Higgins, M.; Staples, O. D.; Tran, F.; Slawin, A. M. Z.; Lain, S.; Westwood, N. J.; Bioorg. Med. Chem., 2012, 20, 1779-1793

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Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

Spencer, J.; Rathnam, R. P.; Harvey, A. L.; Clements, C. J.; Clark, R. L.; Barrett, M. P.; Wong, P. E.; Male, L.; Coles, S. J.; Mackay, S. P.; Bioorg. Med. Chem., 2011, 19, 1802-1815

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Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents

Marhadour, S.; Marchand, P.; Pagniez, F.; Bazin, M. A.; Picot, C.; Lozach, O.; Ruchaud, S.; Antoine, M.; Meijer, L.; Rachidi, N.; Le Pape, P.; Eur. J. Med. Chem., 2012, 58, 543-556

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Synthesis and biological evaluation of an orally active glycosylated endomorphin-1

Varamini, P.; Mansfeld, F. M.; Blanchfield, J. T.; Wyse, B. D.; Smith, M. T.; Toth, I.; J. Med. Chem., 2012, 55(12), 5859-5867

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Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting αvβ3/αvβ5 integrins and IAP proteins

Mingozzi, M.; Manzoni, L.; Arosio, D.; Dal Corso, A.; Manzotti, M.; Innamorati, F.; Pignataro, L.; Lecis, D.; Delia, D.; Seneci, P.; Gennari, C.; Org. Biomol. Chem., 2014, 12, 3288-3302

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Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists

Batie, S.; Lee, J. H.; Jama, R. A:; Browder, D. O.; Montano, L. A.; Huynh, C. C.; Marcus, L. M.; Tsosie, D. G.; Mohammed, Z.; Trang, V.; Marshall, P. A.; Jurutka, P. W.; Wagner, C. E.; Bioorg. Med. Chem., 2013, 21, 693-702

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Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Lawrence, H. R.; Kazi, A.; Luo, Y.; Kendig, R.; Ge, Y.; Jain, S.; Daniel, K.; Santiago, D.; Guida, W. C.; Sebti, S. M.; Bioorg. Med. Chem., 2010, 18(15), 5576-5592

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Synthesis and biological evaluation of second-generation tropanol-based androgen receptor modulators

Sunden, H.; Holland, M. C.; Poutiainen, P. K.; Jaaskelainen, T.; Pulkkinen, J. T.; Palvimo, J. J.; Olsson, R.; J. Med. Chem., 2015, 58, 1569-1574

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Synthesis and cytotoxicity of octahydroepoxyisoindole-7-carboxylic acids and norcantharidin-amide hybrids as norcantharidin analogues

Hizartzidis, L.; Gilbert, J.; Gordon, C. P.; Sakoff, J. A.; McCluskey, A.; ChemMedChem, 2019, 14(12), 1152-1161

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Synthesis and photophysical characterization of 1- and 4-(purinyl)triazoles

Redwan, I. N.; Bliman, D.; Tokugawa, M.; Lawson, C.; Grotli, M.; Tetrahedron, 2013, 69(42), 8857-8864

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Synthesis and reactivity of 3-amino-1H-pyrazolo[4,3-c]pyridin-4(5H)-ones: development of a novel kinase-focussed library

Smyth, L. A.; Matthews, T. P.; Horton, P. N.; Hursthouse, M. B.; Collins, I.; Tetrahedron, 2010, 66, 2843-2854

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Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries

Spencer, J.; Patel, H.; Callear, S. K.; Coles, S. J.; Deadman, J. J.; Tetrahedron Letters, 2011, 52, 5905-5909

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Synthesis and structure–activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase

Luci, D. K.; Jameson, J. B.; Yasgar, A.; Diaz, G.; Joshi, N.; Kantz, A.; Markham, K., Perry, S.; Kuhn, N.; Yeung, J., Kerns, E. H.; Schultz, L.; Holinstat, M.; Nadler, J. L.; Taylor-Fishwick, D. A.; Jadhav, A.; Simeonov, A.; Holman, T. R.; Maloney, D. J.; J. Med. Chem., 2014, 57(2), 495-506

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Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer

Dexheimer, T. S.; Rosenthal, A. S.; Luci, D. K.; Liang, Q.; Villamil, M. A.; Chen, J.; Sun, H.; Kerns, E. H.; Simeonov, A.; Jadhav, a.; Zhuang, Z.; Maloney, D. J.; J. Med. Chem., 2014, 57(19), 8099-8110

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Synthesis and structure–activity relationships of N‐(4‐benzamidino)‐oxazolidinones–potent and selective inhibitors of kallikrein‐related peptidase 6

De Vita, E.; Smits, N.; van den Hurk, H.; Beck, E. M.; Hewitt, J.; Baillie, G.; Russell, E.; Pannifer, A.; Hamon, V.; Morrison, A.; McElroy, S. P.; Jones, P.; Ignatenko, N.; Gunkel, N.; Miller, A. K.; ChemMedChem, 2019, accepted manuscript

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Synthesis and structure–activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors

Ponzano, S.; Bertozzi, F.; Mengatto, L.; Dionisi, M.; Armirotti, A.; Romeo, E.; Berteotti, A.; Fiorelli, C.; Tarozzo, G.; Reggiani, A.; Duranti, A.; Tarzia, G.; Mor, M.; Cavalli, A.; Piomelli, D.; Bandiera, T.; J. Med. Chem., 2013, 56(17), 6917-6934

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Synthesis, anti‐tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones

Leese, M. P.; Jourdan, F. L.; Major, M. R.; Dohle, W.; Thomas, M. P.; Hamel, E.; Ferrandis, E.; Mahon, M. F.; Newman, S. P.; Purohit, A.; Potter, B. V. L.; ChemMedChem, 2014, 9, 798-812

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Synthesis, antitubulin, and antiproliferative SAR of C3/C1‐substituted tetrahydroisoquinolines

Dohle, W.; Leese, M. P.; Jourdan, F. L.; Major, M. R.; Bai, R.; Hamel, E.; Ferrandis, E.; Kasprzyk, P. G.; Fiore, A.; Newman, S. P.; Purohit, A.; Potter, B. V. L.; ChemMedChem, 2014, 9, 350-370

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Synthesis, biological evaluation, and molecular modeling of new 3‑(cyclopentyloxy)-4-methoxybenzaldehyde O‑(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) related phosphodiesterase 4D (PDE4D) inhibitors

Brullo, C.; Massa, M.; Rocca, M; Rotolo, C.; Guariento, S.; Rivera, D.; Ricciarelli, R.; Fedele, E.; Fossa, P.; Bruno, O.; J. Med. Chem., 2014, 57(16), 7061-7072

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Synthesis, biological evaluation, and utility of fluorescent ligands targeting the μ-opioid receptor

Schembri, L. S.; Stoddart, L. A.; Briddon, S. J.; Kellam, B.; Canals, M.; Graham, B.; Scammells, P. J.; J. Med. Chem., 2015, 58(24), 9754-9767

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Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging

Andres, J. I.; Alcazar, J.; Cid, J. M.; De Angelis, M., Iturrino, L.; Langlois, X.; Lavreysen, H.; Trabanco, A. A.; Celen, S.; Bormans, G.; J. Med. Chem., 2012, 55, 8685-8699

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Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging

Andres, J-I.; De Angelis, M.; Alcazar, J.; Iturrino, L.; Langlois, X.; Dedeurwaerdere, S.; Lenaerts, I.; Vanhoof, G.; Celen, S.; Bormans, G.; J. Med. Chem., 2011, 54, 5820-5835

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Synthesis of 3-arylated 3,4-dihydrocoumarins: Combining continuous flow hydrogenation with laccase-catalysed oxidation

Suljic, S.; Pietruszka, J.; Adv. Synth. Catal., 2014, 356(5), 1007-1020

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Synthesis of 3-nitropyrrolidines via dipolar cycloaddition reactions using a modular flow reactor

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Synlett, 2010, 5, 749-752

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Synthesis of 3‐Hydroxypipecolic Acids

Cochi, A.; Pardo, D. G.; Cossy, J.; Eur. J. Org. Chem., 2013, 2013(5), 809-829

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Synthesis of 4-fluoromethylsydnones and their participation in alkyne cycloaddition reactions

Foster, R. S.; Adams, H.; Jakobi, H.; Harrity, J. P. A.; J. Org. Chem., 2013, 78(8), 4049-4064

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Synthesis of 5‐bromomethylfurfural from cellulose as a potential intermediate for biofuel

Kumari, N.; Olesen, J. K.; Pedersen, C. M.; Bols, M.; Eur. J. Org. Chem., 2011, 2011(7), 1266-1270

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Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state

Baltus, C. B.; Press, N. J.; Antonijevic, M. D.; Tizzard, G. J.; Coles, S. J.; Spencer, J.; Tetrahedron, 2012, 68(45), 9272-9277

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Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods

Baumann, M.; Baxendale, I. R.; Kuratli, C.; Ley, S. V.; Martin, R. E.; Schneider, J.; ACS Comb. Sci., 2011, 13(4), 405-413

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Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states

Dayde, B.; Benzaria, S.; Pierra, C.; Gosselin, G.; Surleraux, D.; Volle, J.; Pirat, J.; Virieux, D.; Org. Biomol. Chem, 2012, 10, 3448-3454

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Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate

Howard, P. W.; Chen, Z.; Gregson, S. J.; Masterson, L. A.; Tiberghien, A. C.; Cooper, N.; Fang, M.; Coffils, M. J.; Klee, S.; Hartley, J. A.; Thurston, D. E.; Bioorg. Med. Chem. Lett. 2009, 19(22), 6463-6466

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Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki–Miyaura cross-couplings

Spencer, J.; Baltus, C. B.; Press, N. J.; Harrington, R. W.; Clegg, W.; Tetrahedron Letters, 2011, 52(31), 3963-3968

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Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope

Simerska, P.; Lu, H.; Toth, I.; Bioorg. Med. Chem. Lett., 2009, 19(3), 821-824

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Synthesis of a tetrasaccharide related to the triterpenoid saponin Bellisoside isolated from Bellis perennis (compositae)

Mandal, S.; Sharma, N.; Mukhopadhyay, B.; Tetrahedron: Asymmetry, 2010, 21, 2172-2176

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Synthesis of amines from alcohols in a nonepimerizing one-pot sequence – Synthesis of bioactive compounds: Cinacalcet and dexoxadrol

Guerin, C.; Bellosta, V.; Guillamot, G.; Cossy, J.; Eur. J. Org. Chem., 2012, 15, 2990-3000

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Synthesis of an azabicyclic framework towards (±)-actinophyllic acid

Mortimer, D.; Whiting, M.; Harrity, J. P. A.; Jones, S.; Coldham, I.; Tetrahedron Letters, 2014, 55, 1255-1257

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Synthesis of an undecasaccharide featuring an oligomannosidic heptasaccharide and a bacterial Kdo-lipid A backbone for eliciting neutralizing antibodies to mammalian oligomannose on the HIV-1 envelope spike

Trattnig, N.; Blaukopf, M.; Bruxelle, J-F.; Pantophlet, R.; Kosma, P.; JACS, 2019, 141(19), 7946-7954

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Synthesis of aromatic 13C/2H-α-ketoacid precursors to be used in selective phenylalanine and tyrosine protein labelling

Lichtenecker, R. J.; Org. Biomol. Chem., 2014, 12, 7551-7560

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Synthesis of benzannulated spiroketals using an oxidative radical cyclization

Sperry, J.; Liu, Y-C.; Wilson, Z. E.; Hubert, J. G.; Brimble, M. A.; Synthesis, 2011, 9, 1383-1398

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Synthesis of bioderived cinnolines and their flow-based conversion into 1,4-dihydrocinnoline derivatives

Devlin, J.; Clogher, R.; Baumann, M.; Synlett, 2019, accepted manuscript

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Synthesis of bivalent lactosides based on terephthalamide, N,N-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins

Leyden, R.; Velasco-Torrijos, T.; Andre, S.; Gouin, S.; Gabius, H-J.; Murphy, P. V.; J. Org. Chem., 2009, 74(23), 9010-9026

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Synthesis of condensed heterocycles by the Gould-Jacobs reaction in a novel three-mode pyrolysis reactor

Lengyel, L. C.; Sipos, G.; Sipocz, T.; Vago, T.; Dorman, G.; Gerencser, J.; Makara, G.; Darvas, F.; Org. Process Res. Dev., 2015, 19(3), 399-409

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Synthesis of cross‐linked glycopeptides and ureas by a mechanochemical, solvent‐free reaction and determination of their structural properties by TEM and X‐ray crystallography

Kumar, V.; Giri, S. K.; Venugopalan, P.; Kartha, K. P. R.; ChemPlusChem, 2014, 79(11), 1605-1613

Link to article

Synthesis of four (4″-, 2″-, 2′-, and 6-) monodeoxy analogs of the trisaccharide α-d-Glcp-(1→3)-α-d-Manp-(1→2)-α-d-ManpOMe recognized by Calreticulin/Calnexin

Glinschert, A.; Oscarson, S.; Carbohydrate Research, 2015, 414, 65-71

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Synthesis of functionalized 3-hydroxypiperidines

Wijdeven, M. A.; van Delft, F. L.; Rutjes, F. P. J. T.; Tetrahedron, 2010, 66, 5623-5636

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Synthesis of highly substituted nitropyrrolidines, nitropyrrolizines and nitropyrroles via multicomponent-multistep sequences within a flow reactor

Baumann, M.; Baxendale, I. R.; Kirschning, A.; Ley, S. V.; Wegner, J.; Heterocycles, 2011, 82(2), 1297-1316

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Synthesis of α-substituted vinylsulfonium salts and their application as annulation reagents in the formation of epoxide- and cyclopropane-fused heterocycles

Matlock, J. V.; Fritz, S. P.; Harrison, S. A.; Coe, D. M.; McGarrigle, E. M.; Aggarwal, V. K.; J. Org. Chem., 2014, 79, 10226-10239

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Synthesis of laminarin fragments and evaluation of a β-(1,3) glucan hexasaccaride-CRM197 conjugate as vaccine candidate against Candida albicans

Adamo, R.; Tontini, M.; Brogioni, G.; Romano, M. R.; Contantini, G.; Danieli, E.; Proietti, D.; Berti, F.; Constantino, P.; Journal of Carbohydrate Chemistry, 2011, 30, 249-280

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Synthesis of macrolide-saccharide hybrids by ring-closing metathesis of precursors derived from glycitols and benzoic acids

Matos, M-C.; Murphy, P. V.; J. Org. Chem., 2007, 72, 1803-1806

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Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors

Tite, T.; Tomas, L.; Docsa, T.; Gergely, P.; Kovensky, J.; Gueyrard, D.; Wadouachi, A.; Tetrahedron Letters, 2012, 53, 959-961

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Synthesis of N-hydroxypyrazin-2(1H)-ones via selective O-debenzylation of 1-benzyloxypyrazin-2(1H)-ones using flow methodology

Mai, A. H.; De Borggraeve, W. M.; J. Flow Chem., 2015, 5(1), 6-10

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Synthesis of N-propynyl analogues of peptide nucleic acid (PNA) monomers and their use in the click reaction to prepare N-functionalized PNAs

Howarth, N. M.; Ricci, J.; Tetrahedron, 2011, 67, 9588-9594

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Synthesis of natural and unnatural cyclooligomeric depsipeptides enabled by flow chemistry

Lucke, D.; Dalton, T.; Ley, S. V.; Wilson Z. E.; Chem. Eur. J., 2016, 22(12), 4206-4217

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Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds

Joyard, Y.; Azzouz, R.; Bischoff, L.; Papamicael, C.; Labar, D.; Bol, A.; Bol, V.; Vera, P.; Gregoire, V.; Levacher, V.; Bohn, P.; Bioorg. Med. Chem., 2013, 21, 3680-3688

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Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity

Borcard, F.; Baud, M.; Bello, C.; Dal Bello, G.; Grossi, F.; Pronzato, P.; Cea, M.; Nencioni, A.; Vogel, P.; Bioorg. Med. Chem. Lett., 2010, 20(17), 5353-5356

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Synthesis of Novel Camphor-Derived Bifunctional Thiourea Organocatalysts

Ricko, S.; Golobic, A.; Svete, J.; Stanovnik, B.; Groselj, U.; Chirality, 2015, 27(1), 39-52

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Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups and their evaluation as antimicrobial agents

Workman, D. G.; Hunter, M.; Dover, L. G.; Tetard, D.; Journal of Inorganic Biochemistry, 2016, 160, 49-58

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Synthesis of oxaspiropiperidines as a strategy for lowering logD

Cernak, T.; Dykstra, K.; Levorse, D.; Verras, A.; Balkovec, J.; Nargund, R.; DeVita, R.; Tetrahedron Letters, 2011, 52, 6457-6459

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Synthesis of phenols via fluoride-free oxidation of arylsilanes and arylmethoxysilanes

Rayment, E. J.; Summerhill, N.; Anderson, E. A.; J. Org. Chem., 2012, 77(16), 7052-7060

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Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations

Baumann, M.; Baxendale, I. R.; Hornung, C. H.; Ley, S. V.; Rojo, M. V; Roper, K. A.; Molecules, 2014, 19(7), 9736-9759

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Synthesis of spirocyclic thiazolidinediones using ring-closing metathesis and one-pot sequential ring-closing/cross metathesis

Dhara, K.; Paladhi, S.; Midya, G. C.; Dash, J.; Org. Biomol. Chem., 2011, 9, 3801-3807

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Synthesis of Staphylococcus aureus type 5 capsular polysaccharide repeating unit using novel L-FucNAc and D-FucNAc synthons and immunochemical evaluation

Danieli, E.; Proietti, D.; Brogioni, G.; Romano, M. R.; Cappelletti, E.; Tontini, M.; Berti, F.; Lay, L.; Costantino, P.; Adamo, R.; Bioorg. Med. Chem., 2012, 20, 6403-6415

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Synthesis of sugar-lactams from azides of glucuronic acid

Loukou, C.; Tosin, M.; Muller-Bunz, H.; Murphy, P. V.; Carbohydrate Research, 2007, 342(12-13), 1953-1959

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Synthesis of symmetric dinitro‐functionalised Tröger’s base analogues

Bhuiyan, M. D. H.; Mahon, A. B.; Jensen, P.; Clegg, J. K.; Try, A. C.; Eur. J. Org. Chem., 2009, 5, 687-698

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Synthesis of 2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane (TAIW) from 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazaisowurtzitane (TADBIW) by catalytic hydrogenolysis using a continuous flow process

Dong, K.; Sun, C. H.; Song, J. W., Wei, G. X.; Pang, S. P.; Org. Process Res. Dev., 2014, 18, 1321-1325

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Synthesis of tetrazole analogues of amino acids using Fmoc chemistry: isolation of amino free tetrazoles and their incorporation into peptides

Sureshbabu, V. V.; Venkataramanarao, R.; Naik, S. A.; Chennakirshnareddy, G.; Tetrahedron Letters, 2007, 48(39), 7038-7041

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Synthesis of the tetrasaccharide repeating unit of the β-Kdo-containing exopolysaccharide from Burkholderia pseudomallei and B. cepacia complex

Laroussarie, A.; Barycza, B.; Andriamboavonjy, H.; Kenfack, M. T.; Bleriot, Y.; Gauthier, C.; J. Org. Chem., 2015, 80(20), 10386-10396

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Synthesis of the tetrasaccharide repeating unit of the O-glycan from the polar flagellum flagellin of Azospirillum brasilense Sp7

Pal, K. B.; Mukhopadhyay, B.; Carbohydrate Research, 2014, 400, 9-13

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Synthesis of the trisaccharide repeating unit of the lipopolysaccharide from Moritella viscosa strain M2-226

Pal, K. B.; Verma, P. R.; Gupta, T.; Mukhopadhyay, B.; Journal of Carbohydrate Chemistry, 2015, 34(4), 173-182

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Synthesis of two trisaccharides related to the hepatoprotective phenylethanoids leonoside E and F isolated from Leonurus japonicus Houtt

Budhadev, D.; Mukhopadhyay, B.; Carbohydrate Research, 2014, 384, 51-55

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Synthesis of unique scaffolds via Diels-Alder cycloadditions of tetrasubstituated cyclohexadienes

Jones, A. L.; Snyder, J. K.; Organic Letters, 2010, 12(7), 1592-1595

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Synthesis of γ-valerolactone using a continuous-flow reactor

Tukacs, J. M.; Jones, R. V.; Darvas, F.; Dibo, G.; Lezsak, G.; Mika, L. T.; RSC Adv., 2013, 3, 16283-16287

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Synthesis, SAR, and pharmacological characterization of brain penetrant P2X7 receptor antagonists

Savall, B. M.; Wu, D.; Angelis, M. D.; Carruhters, N. I.; Ao, H.; Wang, Q.; Lord, B.; Bharrachrya, A.; Letavic, M. A.; ACS Med. Chem. Lett., 2015, 6, 671-676

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Synthesis, structure–activity, and structure–stability relationships of 2‐substituted‐N‐(4‐oxo‐3‐oxetanyl) N‐acylethanolamine acid amidase (NAAA) inhibitors

Vitale, R.; Ottonello, G.; Petracca, R.; Bertozzi, S. M.; Ponzano, S.; Armirotti, A.; Berteotti, A.; Dionisi, M.; Cavalli, A.; Piomelli, D.; Bandiera, T.; Bertozzi, F.; ChemMedChem, 2014, 9, 323-336

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Synthetic multivalent ligands for cholera & cholera-like toxins: Protected cyclic neoglycopeptides

Kumar, V.; Yadav, N.; Kartha, K. P. R.; Carbohydrate Research, 2016, 431, 47-55

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Synthetic studies toward the C32–C46 segment of hemicalide. Assignment of the relative configuration of the C36–C42 subunit

Specklin, S.; Boissonnat, G.; Lecourt, C.; Sorin, G.; Lannou, M. I.; Ardisson, J.; Sautel, F.; Massiot, G.; Meyer, C.; Cossy, J.; Org. Lett., 2015, 17(10), 2446-2449

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Systematic evaluation of the palladium-catalyzed hydrogenation under flow conditions

Hattori, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Tetrahedron, 2014, 70(32), 4790-4798

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Tailoring nitrogen-doped carbons as hosts for single-atom catalysts

Buchele, S.; Chen, Z.; Mitchell, S.; Hauert, R.; Krumeich, F.; Perez-Ramirez, J.; ChemCatChem, 2019, 11(12), 2812-2820

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Taming hazardous chemistry by continuous flow technology

Movsisyan, M.; Delbeke, E. I. P.; Berton, J. K. E. T.; Battilocchio, C.; Ley, S. V.; Stevens, C. V.; Chem. Soc. Rev., 2016, 45, 489-4928

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Telescoped sequence of exothermic and endothermic reactions in multistep flow synthesis

Sharma, Y.; Nikam, A. V.; Kulkarni, A. A.; Org. Process Res. Dev., 2018, 23(2), 170-176

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Tetrahydroisoquinolinone‐based steroidomimetic and chimeric microtubule disruptors

Leese, M. P.; Jourdan, F. L.; Major, M. R.; Dohle, W.; Hamel, E.; Ferrandis, E.; Fiore, A.; Kasprzyk, P. G.; Potter, B. V. L.; ChemMedChem, 2014, 9(1), 85-108

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The changing face of organic synthesis

Ley, S. V.; Baxendale, I. R.; Chimia, 2008, 62(3), 162-168

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The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors

Carter, C. F.; Baxendale, I. R.; Pavey, J. B. J.; Ley, S. V.; Org. Biomol. Chem., 2010, 8, 1588-1595

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The continuous synthesis and application of graphene supported palladium nanoparticles: a highly effective catalyst for Suzuki-Miyaura cross-coupling reactions

Brinkley, K. W.; Burkholder, M.; Siamaki, A. R.; Belecki, K.; Gupton, B. F.; Green Process. Synth., 2015, 4(3), 241-246

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The Cooperative Research Centre for Cancer Therapeutics: bridging the gap between leading cancer research at Australia’s universities and developing novel cancer drugs

Baell, J. B.; Heathers, G.; Sage, C.; Future Med. Chem., 2010, 2, 941-947

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The development of poly(dendrimer)s for advanced processing

Gunning, J. P.; Levell, J. W.; Wyatt, M. F.; Burn, P. L.; Robertson, J.; Samuel, I. D. W.; Polym. Chem., 2010, 1, 730-738

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The dual reactivity of Weinreb amides applied to the late-stage divergent functionalisation of meso pyrrolidines

Boufroura, H.; Sevaille, L.; Gigant, N.; Drege, E.; Joseph, D.; New J. Chem., 2018, 42, 12403-12411

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The expanding utility of continuous flow hydrogenation

Cossar, P. J.; Hizartzidis, L.; Simone, M. I.; McCluskey A.; Gordon, C. P.; Org. Biomol. Chem., 2015, 13, 7119-7130

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The first case of competitive heterogeneously catalyzed hydrogenation using continuous-flow fixed-bed reactor system: Hydrogenation of binary mixtures of activated ketones on Pt-alumina and on Pt-alumina-cinchonidine catalysts

Szollosi, G.; Makra, Z.; Fulop, F.; Bartok, M.; Catalysis Letters, 2011, 141, 1616-1620

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The flow synthesis of heterocycles for natural product and medicinal chemistry applications

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Molecular Diversity, 2011, 15(3), 613-630

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The future of organic synthesis

Kundig, P.; Science, 2006, 314, 430-431

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The identification of indacaterol as an ultralong-acting inhaled β2-adrenoceptor agonist

Baur, F.; Beattie, D.; Beer, D.; Bentley, D.; Bradley, M.; Bruce, I.; Charlton, S. J.; Cuenoud, B.; Ernst, R.; Fairhurst, R. A.; Faller, B.; Farr, D.; Keller, T.; Fozard, J. R.; Fullerton, J.; Garman, S.; Hatto, J.; Hayden, C.; He, H.; Howes, C.; Janus, D.; Jiang, Z.; Lewis, C.; Loeuillet-Ritzler, F.; Moser, H.; Reilly, J.; Steward, A.; Sykes, D.; Tedaldi, L.; Trifilieff, A.; Tweed, M.; Watson, S.; Wissler, E.; Wyss, D.; J. Med. Chem., 2010, 53, 3675-3684

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The integration of flow reactors into synthetic organic chemistry

Baxendale, I. R.; J. Chem. Technol. Biotechnol., 2013, 88, 519-552

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The microwave-to-flow paradigm: Translating high-temperature batch microwave chemistry to scalable continuous-flow processes

Glasnov, T. N.; Kappe, C. O.; Chem. Eur. J., 2011, 17, 11956-11968

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The recent advancement of hydrogenation technology and their implications for drug discovery research

Spadoni, C.; Jones, R.; Urge, L.; Darvas, F.; Chemistry Today, 2005, January/February, 36-39

The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches

Gordon, P. C.; Org. Biomol. Chem., 2018, 16, 180-196

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The role of flow in green chemistry and engineering

Newman, S. G.; Jensen, K. F.; Green Chem., 2013, 15, 1456-1472

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The role of water in catalytic biomass-based technologies to produce chemicals and fuels

Mika, L. T.; Csefalvay, E.; Horvath, I. T.; Catalysis Today, 2015, 247, 33-46

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The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

Baumann, M.; Baxendale, I. R.; Beilstein J. Org. Chem., 2015, 11, 1194-1219

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The synthesis of azabicyclic heterocycles

Darout, E.; Basak, A.; Tetrahedron Letters, 2010, 51, 2998-3001

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The titanium-mediated double reductive cleavage of cyclic sulfonamides for the synthesis of aryl pyrrolidines

Khalifa, A.; Evans, P.; J. Org. Chem., 2019, 84(5), 2969-2975

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The use of a continuous flow-reactor employing a mixed hydrogen–liquid flow stream for the efficient reduction of imines to amines

Saaby, S.; Knudsen, K. R.; Ladlow, M., Ley, S. V.; Chem. Commun., 2005, 23, 2909-2911

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The use of gases in flow synthesis

Mallia, C. J.; Baxendale, I. R.; Org. Process Res. Dev., 2016, 20(2), 327-360

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Titanium nitride-nickel nanocomposite as heterogeneous catalyst for the hydrogenolysis of aryl ethers

Molinari, V.; Giordano, C.; Antonietti, M.; Esposito, D.; J. Am. Chem. Soc., 2014, 136(5), 1758-1761

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Tools for chemical synthesis in microsystems

Jensen, K. F.; Reizman, B. J.; Newman, S. G.; Lab. Chip, 2014, 14, 3206-3212

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Tools for efficient high-throughput synthesis

Chighine, A.; Sechi, G.; Bradley, M.; Drug Discovery Today, 2007, 12, 459-464

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Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2

Adams, D. R.; Tawati, S.; Berretta, G.; Rivas, P. L.; Baiget, J.; Jiang, Z.; Alsfouk, A.; MacKay, S. P.; Pyne, N.; Pyne, S.; J. Med. Chem., 2019, 62(7), 3658-3676

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Total syntheses of the dipyrrolobenzoquinone (+)-terreusinone enabled by an evaluation of 4-methylpent-1-yn-3-ols in the Larock indole synthesis

Wang, C.; Sperry, J.; Tetrahedron, 2013, 69(23), 4563-4577

Link to article

Total synthesis and biological evaluation of tubulysin analogues

Colombo, R.; Wang, Z.; Han, J.; Balachandran, R.; Daghestani, H. N.; Camarco, D. P.; Vogt, A.; Day, B. W.; Mendel, D.; Wipf, P.; J. Org. Chem., 2016, 81(21), 10302-10320

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Total synthesis of (±)-monomorine

Le, T. Q.; Oliver, R. M.; Arcari, J. T.; Mitton-Fry, M. J.; Tetrahedron Letters, 2012, 53(42), 5660-5662

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Total synthesis of (±)-taiwaniaquinol F and related taiwaniaquinoids

Kakde, B. N.; Kumari, P.; Bisai, A.; J. Org. Chem., 2015, 80(20), 9889-9899

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Total synthesis of aignopsanes, a class of sesquiterpenes: (+)‐Aignopsanoic acid A, (−)‐methyl aignopsanoate A, and (−)‐isoaignopsanoic A

Burki, C.; Bonjoch, J.; Bradshaw, B.; Villa, G.; Renaud, P.; Chem. Eur. J., 2015, 21(1), 395-401

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Total synthesis of the macrocyclic N-methyl enamides palmyrolide A and 2S-sanctolide A

Wadsworth, A. D.; Furkert, D. P.; Brimble, M. A.; J. Org. Chem., 2014, 79(22), 11179-11193

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Total synthesis, stereochemical assignment, and biological activity of chamuvarinin and structural analogues

Florence, G. J.; Morris, J. C.; Murray, R. G.; Vanga, R. R.; Osler, J. D.; Smith, T. K.; Chem. Eur. J., 2013, 19, 8309-8320

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Toward a continuous-flow synthesis of Boscalid®

Glasnov, T. N.; Kappe; C. O.; Adv. Synth. Catal., 2010, 352, 3089-3097

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Toward the synthesis of noroxymorphone via aerobic palladium-catalyzed continuous flow N-demethylation strategies

Gutmann, B.; Elsner, P.; Cox, D. P.; Weigl, U.; Roberge, D. M.; Kappe, C. O.; ACS Sustainable Chem. Eng., 2016, 4(11), 6048-6061

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Towards a continuous flow environment for lipase-catalyzed reactions

Itabaiana, I., Jr.; Soter de Mariz e Miranda, L.; de Souza, R. O. M. A.; Journal of Molecular Catalysis B: Enzymatic, 2013, 85-86, 1-9

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Towards industrial furfural conversion: Selectivity and stability of palladium and platinum catalysts under continuous flow regime

Ouyang, W.; Yepez, A.; Romero, A. A.; Luque, R.; Catalysis Today, 2018, 308, 32-37

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Towards the development of chromone-based MEK1/2 modulators

Redwan, I. N.; Dyrager, C.; Solano, C.; de Troconiz, G. F.; Voisin, L.; Bliman, D.; Meloche, S.; Grotli, M.; Eur. J. Med. Chem., 2014, 85, 127-138

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Transfer hydrogenation of levulinic acid under hydrothermal conditions catalyzed by sulfate as a temperature-switchable base

Kopetzki, D.; Antonietti, M.; Green Chem., 2010, 12, 656-660

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Transition-metal-catalyzed cyclopropanation of nonactivated alkenes in dibromomethane with triisobutylaluminium

Brunner, G.; Elmer, S.; Schroder, F.; Eur. J. Org. Chem., 2011, 4623-4633

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Translating high-temperature microwave chemistry to scalable continuous flow processes

Damm, M.; Glasnov, T. N.; Kappe, C. O.; Org. Process Res. Dev., 2010, 14(1), 215-224

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Treatments of lignocellulosic hydrolysates and continuous-flow hydrogenation of xylose to xylitol

Feher, A.; Feher, C.; Rozbach, M.; Racz, G.; Fekete, M.; Hegedus, L.; Barta, Z.; Chem. Eng. Technol., 2018, 41(3), 496-503

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Tunability and scalability of single-atom catalysts based on carbon nitride

Chen, Z.; Mitchell, S.; Krumeich, F.; Hauert, R.; Yakunin, S.; Kovalenko, M. V.; Perez-Ramirez, J.; ACS Sustainable. Chem. Eng., 2019, 7(5), 5223-5230

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Tuning nano-nickel selectivity with tin in flow hydrogenation of 6-methyl-5-hepten-2-one by surface organometallic chemistry modification

Zienkiewicz-Machnik, M.; Goszewska, I.; Srebowata, A.; Kubas, A.; Gizinski, D.; Slowik, G.; Matus, K.; Lisovytskiy, D.; Pisarek, M.; Sa, J.; Catalysis Today, 2018, 308, 38-44

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Tyrosinases in organic chemistry: A versatile tool for the α‐arylation of β‐dicarbonyl compounds

Krug, R.; Schroder, D.; Gebauer, J.; Suljic, S.; Morimoto, Y.; Fujieda, N.; Itoh, S.; Pietruszka, J.; Eur. J. Org. Chem., 2018, 2018(15), 1789-1796

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Unusual behavior in the reactivity of 5-substituted- 1H-tetrazoles in a resistively heated microreactor

Gutmann, B.; Glasnov, T. N.; Razzaq, T.; Goessler, W.; Roberge, D. M.; Kappe, C.O.; Beilstein J. Org. Chem., 2011, 7, 503-517

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User friendly and flexible Kiliani reaction on ketoses using microreaction technology

Cukalovic, A.; Monbaliu, J-C., M.; Heynderickx, G. J.; Stevens, C. V.; J. Flow Chem., 2012, 2(2), 43-46

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Using chemical probes to investigate the sub-inhibitory effects of azithromycin

Glansdorp, F. G.; Spandl, R. J.; Swatton, J. E.; Loiseleur, O.; Welch, M.; Spring, D. R.; Org. Biomol. Chem., 2008, 6, 4120-4124

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Using continuous processes to increase production

Anderson, N. G.; Org. Process Res. Dev., 2012, 16(5), 852-869

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Valorization of humins-extracted 5-methoxymethylfurfural: Toward high added value furanics via continuous flow catalytic hydrogenation

Pfab, E.; Filiciotto, L.; Romero, A. A.; Luque, R.; Ind. Eng. Chem. Res., 2019, 58(35), 16065-16070

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Valorization of lignin waste from hydrothermal treatment of biomass

Chieffi, G.; Fechler, N.; Esposito, D.; RSC Adv., 2015, 5(78), 63691-63696

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Versatile dual hydrogenation-oxidation nanocatalysts for the aqueous transformation of biomass-derived platform molecules

Garcia-Suarez, E. J.; Balu, A. M.; Tristany, M.; Garcia, A. B.; Philippot, K.; Luque, R.; Green Chem., 2012, 14, 1434-1439

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Versatile low-loaded mechanochemically synthesized supported iron oxide nanoparticles for continuous flow alkylations

Balu, A. M.; Pineda, A.; Obermayer, D.; Romero, A. A., Kappe, C. O.; Luque, R.; RSC Adv., 2013, 3, 16292-16295

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Visible-light-mediated iodoperfluoroalkylation of alkenes in flow and its application to the synthesis of a key Fulvestrant intermediate

Rosso, C.; Williams, J. D.; Filippini, G.; Prato, M.; Kappe, C. O.; Org. Lett., 2019, 21(13), 5341-5345

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Visually following the hydrogenation of curcumin to tetrahydrocurcumin in a natural product experiment that enhances student understanding of NMR spectroscopy

Wagner, C. E.; Marshall, P. A.; Cahill, T. M.; Mohamed, Z.; J. Chem. Educ., 2013, 90(7), 930-933

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VUT-MK142: a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes

Koley, M.; Mike, A. K.; Heher, P.; Koenig, X.; Schon, M.; Schnurch, M.; Hilber, K.; Weitzer, G.; Mihovilovic, M. D.; Med. Chem. Commun., 2013, 4, 1189-1195

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Yolk‐shell‐mesostructured silica‐supported dual molecular catalyst for enantioselective tandem reactions

Wu, L.; Li, Y.; Meng, J.; Jin, R.; Lin, J.; Liu, G.; ChemPlusChem, 2018, 83(9), 861-867

Link to article