Publications - ThalesNano

1,3,5-Trisubstituted pyrazoles as potent negative allosteric modulators of the mGlu2/3 receptors

Van Gool, M.; Alonso De Diego, S. A.; Delgado, O.; Trabanco, A. A.; Jourdan, F.; Macdonald, G. J.; Somers, M.; Ver Donck, L.; ChemMedChem, 2017, 12(12), 905-912

Link to article

1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activity

Abdel-Hamid, M. K.; Macgregor, K. A.; Odell, L. R.; Chau, N.; Mariana, A.; Whiting, A.; Robinson, P. J.; McCluskey, A.; Org. Biomol. Chem., 2015, 13, 8016-8028

Link to article

2,7-Pyrrolo[2,1-f][1,2,4]triazines as JAK2 inhibitors: modification of target structure to minimize reactive metabolite formation

Weinberg, L. R.; Albom, M. S.; Angeles, T. S.; Breslin, H. J.; Gingrich, D. E.; Huang, Z.; Lisko, J. G.; Mason, J. L.; Milkiewicz, K. L.; Thieu, T. V.; Underiner, T.L .; Wells, G. J.; Wells-Knecht, K. J.; Dorsey, B. D.; Bioorg. Med. Chem. Lett., 2011, 21(4), 7325-7330

Link to article

3‐Aminoazetidin‐2‐one derivatives as N‐acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration

Fiasella, A.; Nuzzi, A.; Summa, M.; Armirotti, A.; Tarozzo, G.; Tarzia, G.; Mor, M.; Bertozzi, F.; Bandiera, T.; Piomelli, D.; ChemMedChem, 2014, 9(7), 1602-1614

Link to article

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Ferrins, L.; Rahmani, R.; Sykes, M. L.; Jones, A. J.; Avery, V. M.; Teston, E.; Almohaywi, B.; Yin, J.; Smith, J.; Hyland, C.; White, K. L.; Ryan, E.; Campbell, M.; Charman, S. A.; Kaiser, M.; Baell, J. B.; Eur. J. Med. Chem., 2013, 66, 450-465

Link to article

3-Substituted xanthines as promising candidates for quadruplex formation: computational, synthetic and analytical studies

Szolomajer, J.; Paragi, G.; Batta, Gy.; Guerra, F. C.; Bickelhaupt, F. M.; Kele, Z.; Padar, P.; Kupihar, Z.; Kovacs, L.; New Journal of Chemistry, 2011, 35, 476-482

Link to article

4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as high-affinity non-imidazole histamine H3 receptor agonists with in vivo central nervous system activity

4′-C-methyl-2-deoxyadenosine and 4-C-ethyl-2-deoxyadenosine inhibit HIV-1 replication

Vu, B. C.; Boyer, P. L.; Siddiqui, M. A.; Marquez, V. E.; Hughes, S. H.; Antimicrobial Agents and Chemotheraphy, 2011, 55(5), 2379-2389

Link to article

4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-based P2X7 receptor antagonists: optimization of pharmacokinetic properties leading to the identification of a clinical candidate

Letavic, M. A.; Savall, B. M.; Allison, B. D.; Aluisio, L.; Andres, J. I.; De Angelis, M.; Ao, H.; Beauchamp, D. A.; Bonaventure, P.; Bryant, S.; Carruthers, N. I.; Ceusters, M.; Coe, K. J.; Dvorak, C. A.; Fraser, I. C.; Gelin, C. F.; Koudriakova, T.; Liang, J.; Lord, B.; Lovenberg, T. W.; Otieno, M. A.; Schoetens, F.; Swanson, D. M.; Wang, Q.; Wickenden, A. D.; Bhattacharya, A.; J. Med. Chem., 2017, 60(11), 4559-4572

Link to article

Synthesis, antiplasmodial activity and in silico molecular docking study of pinocembrin and its analogs

Synthesis of 12β-methyl-18-nor-avicholic acid analogues as potential TGR5 agonists

α-1,4-Galactosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins

Simerska, P.; Christie, M. P.; Goodwin, D.; Jen, F. E-C.; Jennings, M. P.; Toth, I.; Journal of Molecular Catalysis B: Enzymatic, 2013, 97, 196-202

Link to article

A benchtop continuous flow reactor: a solution to the hazards posed by gas cylinder based hydrogenation

Dorman, G.; Kocsis, L.; Jones, R.; Darvas, F.; Journal of Chemical Health and Safety, 2013, 20(4), 3-8

Link to article

A comparative assessment study of known small-molecule Keap1−Nrf2 protein–protein interaction inhibitors: Chemical synthesis, binding properties, and cellular activity

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

Baumann, M.; Baxendale, I. R.; Deplante, F.; Beilstein J. Org. Chem., 2017, 13, 2549-2560

Link to article

A concise stereoselective synthesis of pterosin B

Dexter, H. R.; Allen, E.; Williams, D. M.; Tetrahedron Letters, 2018, 59(49), 4323-4325

Link to article

A continuous-flow approach to palladium-catalyzed alkoxycarbonylation reactions

Kelly, C. B.; Lee, C. (X.); Mercadante, M. A.; Leadbeater N. E.; Org. Process Res. Dev., 2011, 15(3), 717-720

Link to article

A continuous-flow microwave reactor for conducting high-temperature and high-pressure chemical reactions

Sauks, J. M.; Mallik, D.; Lawryshyn, Y.; Bender, T.; Organ, M.; Org. Process Res. Dev., 2014, 18(11), 1310-1314

Link to article

A continuous flow process for the green and sustainable production of N-alkyl imidazoles

Fekete, M.; Kocsis L.; Dorman, G.; Jones, R. V.; Darvas, F.; Green Processing and Synthesis, 2016, 5(3), 239-246

Link to article

A continuous flow process for the production of 2,5-dimethylfuran from fructose using (non-noble metal based) heterogeneous catalysis

Braun, M.; Antonietti, M.; Green Chemistry, 2017, 19, 3813-3819

Link to article

A continuous flow strategy for the facile synthesis and elaboration of semi-saturated heterobicyclic fragments

Luise, N.; Wyatt, E. W.; Tarver, G. J.; Wyatt, P. G.; Eur. J. Org. Chem., 2018, 2019(6), 1341-1349

Link to article

A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

Viviano, M.; Milite, C.; Rescigno, D.; Castellano, S.; Sbardella, G.; RSC Adv., 2015, 5, 1268-1273

Link to article

A continuous flow system for asymmetric hydrogenation using supported chiral catalysts

Madarasz, J.; Farkas, G.; Balogh, S.; Szollosy, A.; Kovacs, J.; Darvas, F.; Urge, L.; Bakos, J.; J. Flow Chem., 2011, 1(2), 62-67

Link to article

A continuous-flow, two-step, metal-free process for the synthesis of differently substituted chiral 1,2-diamino derivatives

Pirola, M.; Compostella, M. E.; Raimondi, L.; Puglisi, A.; Benaglia, M.; Synthesis, 2018, 50, 1430-1438

Link to article

A continuous process for glyoxal valorisation using tailored Lewis-acid zeolite catalysts

Dapsens, P. Y.; Mondelli, C.; Kusema, B. T.; Verel, R., Perez-Ramirez, J.; Green Chemistry, 2014, 16, 1176-1186

Link to article

A Continuous‐Flow Process for Palladium‐Catalyzed Olefin Cleavage by using Oxygen within the Explosive Regime

A convenient total synthesis of PSMA-617: A prostate specific membrane antigen (PSMA) ligand for prostate cancer endotherapeutic applications

A Facile hybrid ‘flow and batch’ access to substituted 3,4-dihydro-2H-benzo[b][1,4]oxazinones

A facile, protic ionic liquid route to N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides and N-substituted 3-oxoisoindoline-4-carboxylic acids

Gordon, C. P.; Byrne, N.; McCluskey, A.; Green Chem., 2010, 12, 1000-1006

Link to article

A flexible approach to 6,5-benzannulated spiroketals

Wilson, Z. E.; Hubert, J. G.; Brimble, M. A.; Eur. J. Org. Chem., 2011, 2011(20-21), 3938-3945

Link to article

A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core

Hay, D. A.; Adam, F. M.; Bish, G.; Calo, F.; Dixon, R.; Fray, M. J.; Hitchin, J.; Jones, P.; Paradowski, M.; Parsons, G. C.; Proctor, K. J. W.; Pryde, D. C.; Smith, N. N.; Tran, T. D.; Tetrahedron Letters, 2011, 52(44), 5728-5732

Link to article

A flow-based synthesis of telmisartan

Martin, A. D.; Siamaki, A. R.; Belecki, K.; Gupton, B. F.; J. Flow Chem., 2015, 5(3), 145-147

Link to article

A flow-based transition-metal-catalysed hydrogenolysis strategy to facilitate peptide side-chain deprotection

A flow chemistry route to 2-phenyl-3-(1H-pyrrol-2-yl)propan-1-amines

Tarleton, M.; McCluskey, A.; Tetrahedron Letters, 2011, 52(14), 1583-1586

Link to article

A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.; Chem. Commun., 2006, 2566-2568

Link to article

A flow process using microreactors for the preparation of a quinolone derivative as a potent 5HT1B antagonist

Qian, Z.; Baxendale, I. R.; Ley, S. V.; Synlett, 2010, 4, 505-508

Link to article

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K.; Chem. Commun., 2006, 4835-4837

Link to article

A gram-scale batch and flow total synthesis of perhydrohistrionicotoxin

Brasholz, M.; Macdonald, J. M.; Saubern, S.; Ryan, J. H.; Holmes, A. B.; Chem. Eur. J., 2010, 16(37), 11471-11480

Link to article

A Green Process for the Preparation of Bis(2,2,2-trifluoroethyl) Methylphosphonate

A method to identify best available technologies (BAT) for hydrogenation reactors in the pharmaceutical industry

Van Le Doan, T.; Stavarek, P.; de Bellefon, C.; J. Flow Chem., 2012, 2(3), 77-82

Link to article

A modular synthesis of teraryl‐based α‐helix mimetics, part 2: Synthesis of 5‐pyridine boronic acid pinacol ester building blocks with amino acid side chains in 3‐position

A multi-step continuous flow synthesis of pomalidomide

A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands

Petersen, T. P.; Ritzen, A.; Ulven, T.; Org. Lett., 2009, 11(22), 5134-5137

Link to article

A novel agonist of the type 1 lysophosphatidic acid receptor (LPA1), UCM-05194, shows efficacy in neuropathic pain amelioration

A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells

Kim, J.; Moon, S. H.; Kim, B. T.; Chae, C. H.; Lee, J. Y.; Kim, S. H.; PLoS One, 2014, 9(10), e110180

Link to article

A novel method for high-throughput reduction of compounds through automated sequential injection into a continuous-flow microfluidic reactor

Jones, R.; Godorhazy, L.; Szalay, D.; Gerencser, J.; Dorman, G.; Urge, L.; Darvas, F.; QSAR Comb. Sci., 2005, 24(6), 722-727

Link to article

A practical and benign synthesis of amines through Pd@mpg-C3N4 catalyzed reduction of nitriles

Li, Y.; Gong, Y.; Xu, X.; Zhang, P.; Li, H.; Wang, Y.; Catalysis Communications, 2012, 28, 9-12

Link to article

A remote-controlled adaptive medchem lab: an innovative approach to enable drug discovery in the 21st Century

Godfrey, A. G.; Masquelin, T.; Hemmerle, H.; Drug Discovery Today, 2013, 18(17-18), 795-802

Link to article

A safe and selective method for reduction of 2-nitrophenylacetic acid systems to N-aryl hydroxamic acids using continuous flow hydrogenation

Ichire, O.; Jans, P.; Parfenov, G.; Dounay, A. B.; Tetrahedron Letters, 2017, 58(6), 582-585

Link to article

A scalable two-step continuous flow synthesis of nabumetone and related 4-aryl-2-butanones

Viviano, M.; Glasnov, T. N.; Reichard, B.; Tekautz, B.; Kappe, C. O.; Org. Process Res. Dev., 2011, 15, 858-870

Link to article

A simple chemical model for clathrate hydrate inhibition by polyvinylcaprolactam

Davenport, J. R.; Musa, O. M.; Paterson, M. J.; Piepenbrock, M. O. M.; Fucke, K.; Steed, J. W.; Chem. Commun., 2011, 47, 9891-9893

Link to article

A simple, efficient, and selective deuteration via a flow chemistry approach

Mandity, I. M.; Martinek, T. A.; Darvas, F.; Fulop, F.; Tetrahedron Letters, 2009, 50, 4372-4374

Link to article

A small footprint oxycodone generator based on continuous flow technology and real-time analytics

A stereoselective, catalytic strategy for the in-flow synthesis of advanced precursors of rasagiline and tamsulosin

Brenna, D.; Pirola, M.; Raimondi, L.; Burke, A. J.; Benaglia, M.; Bioorg. Med. Chem., 2017, 25(23), 6242-6247

Link to article

A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors

Gordon, C. P.; Dalton, N.; Vandegraaff N.; Deadman, J.; Rhodes, D. I.; Coates, J. A.; Pyne, S. G.; Griffith, R.; Bremner, J. B.; Keller, P. A.; Tetrahedron, 2018, 74(12), 1253-1268

Link to article

A sustainable and chemoselective continuous flow hydrogenation of functionalized 2-azetines to azetidines

A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir

Dalla-Vechia, L.; Reichart, B.; Glasnov, T. N.; Miranda, L. S. M.; Kappe, C. O.; de Souza, R. O. M. A.; Org. Biomol. Chem., 2013, 11, 6806-6813

Link to article

A ‘turn-on’ fluorescence glycosyl dithiocarbamate probe for selective fluoride sensing in aqueous medium

Das, R.; Mishra, B.; Mukhopadhyay, B.; Synlett, 2018, 29(15), 2001-2005

Link to article

A two‐step continuous‐flow synthesis of N‐(2‐aminoethyl)acylamides through ring‐opening/hydrogenation of oxazolines

Gutmann, B.; Roduit, J. P.; Roberge, D.; Kappe, C. O.; Chem. Eur. J., 2011, 17, 13146-13150

Link to article

A versatile biobased continuous flow strategy for the production of 3-butene-1,2-diol and vinyl ethylene carbonate from erythritol

A versatile de novo synthesis of legionaminic acid and 4-epi-legionaminic acid starting from D-serine

Gintner, M.; Yoneda, Y.; Schmölzer, C.; Denner, C.; Kahlig, H.; Schmid, W.; Carbohydrate Research, 2019, 474, 34-42

Link to article

A Warburg effect targeting vector designed to increase the uptake of compounds by cancer cells demonstrates glucose and hypoxia dependent uptake

Access to optically active 3‐aminopiperidines by ring expansion of prolinols: Thermodynamic versus kinetic control

Cochi, A. ; Pardo, D. G.; Cossy, J.; Eur. J. Org. Chem., 2012, 2012(10), 2023-2040

Link to article

Accessing novel process windows in a high‐temperature/pressure capillary flow reactor

Razzaq, T.; Glasnov, T. N.; Kappe, C. O.; Chem. Eng. Technol., 2009, 32(11), 1702-1716

Link to article

Activity of continuous flow synthesized Pd-based nanocatalysts in the flow hydroconversion of furfural

Garcia-Olmo, A. J.; Yepez, A.; Balu, A. M.; Prinsen, P.; Garcia, A.; Maziere, A.; Len, C.; Luque, R.; Tetrahedrom, 2017, 73(38), 5599-5604

Link to article

Acylguanidine beta secretase 1 inhibitors: a combined experimental and free energy perturbation study

Keranen, H.; Perez-Benito, L.; Ciordia, M.; Delgado, F.; Steinbrecher, T. B.; Oehlrich, D.; van Vlijmen, H. W. T.; Trabanco, A. A.; Tresadern, G.; J. Chem. Theory Comput., 2017, 13, 1439-1453

Link to article

Adaptive and automated system-optimization for heterogeneous flow-hydrogenation reactions

Additive manufacturing technologies: 3D printing in organic synthesis

Advanced Real-Time Process Analyticsfor Multistep Synthesis in Continuous Flow

Aerobic flow oxidation of alcohols in water catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

Osako, T.; Torii, K.; Uozumi, Y.; RSC Adv., 2015, 5, 2647-2654

Link to article

Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries

Alkyne–azide cycloadditions with copper powder in a high‐pressure continuous‐flow reactor: High‐temperature conditions versus the role of additives

Otvos, S. B.; Mandity, I. M.; Kiss, L.; Fulop, F.; Chem. Asian J., 2013, 8(4), 800-808

Link to article

Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitor

Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization

Whelligan, D. K.; Solanki, S.; Taylor, D.; Thomson, D. W.; Cheung, K. J.; Boxall, K.; Mas-Droux, C.; Barillari, C.; Burns, S.; Grummitt, C. G.; Collins, I.; van Montfort, E. L. M.; Aherne, G. W.; Bayliss, R.; Hoelder, S.; J. Med. Chem., 2010, 53, 7682-7698

Link to article

An alternative route for fondaparinux sodium synthesis via selective hydrogenations and sulfation of appropriate pentasaccharides

Manikowski, A.; Koziol, A.; Czajkowska-Wojciechowska, E.; Carbohydrate Research, 2012, 361, 155-161

Link to article

An efficient and more sustainable one-step continuous-flow multicomponent synthesis approach to chromene derivatives

Vaddula, B. R.; Yalla, S.; Gonzalez, M. A.; J. Flow Chem., 2015, 5(3), 172-177

Link to article

An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process

Sedelmeier, J.; Ley, S. V.; Baxendale, I. R.; Green Chem., 2009, 11, 683-685

Link to article

An efficient continuous flow approach to furnish furan-based biaryls

Trinh, T. N.; Hizartzidis, L.; Lin, A. J. S.; Harman, D. G.; McCluskey, A.; Gordon, C. P.; Org. Biomol. Chem., 2014, 12, 9562-9571

Link to article

An imidazolium-based organopalladium-functionalized organic–inorganic hybrid silica promotes one-pot tandem Suzuki cross coupling–reduction of haloacetophenones and arylboronic acids

Zhang, D.; Cheng, T.; Liu, G.; Applied Catal. B: Environmental, 2015, 174-175, 344-349

Link to article

An Integrated Continuous-Flow Synthesis of a Key Oxazolidine Intermediate to Noroxymorphone from Naturally Occurring Opioids

An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor

Russell, C.; Lin, A. J. S.; Hains, P.; Simone, M. I.; Robinson, P. J.; McCluskey, A.; RSC Adv., 2015, 5, 93433-93437

Link to article

An orally bioavailable, indole-3-glyoxylamide based series of tubulin polymerization inhibitors showing tumor growth inhibition in a mouse xenograft model of head and neck cancer

Colley, H. E.; Muthana, M.; Danson, J. S.; Jackson, L. V.; Brett, M. L.; Harrison, J.; Coole, S. F.; Mason, D. P.; Jennings, L. R.; Wong, M.; Tulasi, V.; Noraman, D.; Lockey, P. M.; Williams, L.; Dossetter, A. G.; Griffen, E. J.; Thompson, M. J.; J. Med. Chem., 2015, 58(23), 9309-9333

Link to article

Application of continuous flow and alternative energy devices for 5-hydroxymethylfurfural production

Schon, M.; Schnurch, M.; Mihovilovic, M. D.; Mol. Divers., 2011, 15, 639-643

Link to article

Application of deuterated THENA for assigning the absolute configuration of chiral secondary alcohols

Soponpong, J.; Dolsophon, K.; Thongpanchang, C.; Linden, A.; Thongpanchang, T.; Tetrahedron Letters, 2019, 60(6), 497-500

Link to article

Application of factorial design of experiments for the continuous hydrogenation of enriched castor oil methyl esters

Neeharika, T. S. V. R.; Rani, K. N. P.; Rao, K. V. S. A.; Kumar, T. P.; Prasad, R. B. N.; Bulletin of Chemical Reaction Engineering & Catalysis, 2013, 8(2), 154-159

Link to article

Application of metal‐based reagents and catalysts in microstructured flow devices

Chinnusamy, T.; Yudha S. S.; Hager, M.; Kreitmeier, P.; Reisen, O.; ChemSusChem, 2012, 5(2), 247-255

Link to article

Applying flow chemistry: Methods, materials, and multistep synthesis

McQuade, D. T.; Seeberger, P. H.; J. Org. Chem., 2013, 78(13), 6384-6389

Link to article

Approaches for Performing Reductions under Continuous-Flow Conditions

Approaches to pyranuronic β-sugar amino acid building blocks of peptidosaccharide foldamers

Aqueous flow hydroxycarbonylation of aryl halides catalyzed by an amphiphilic polymer-supported palladium–diphenylphosphine catalyst

Osako, T.; Kaiser, R.; Torii, K.; Uozumi, Y.; Synlett, 2019, 30, 961-966

Link to article

Assessing a sustainable manufacturing route to lapatinib

Assignment of vibrational circular dichroism cross‐referenced electronic circular dichroism spectra of flexible foldamer building blocks: Towards assigning pure chiroptical properties of foldamers

Asymmetric aldol reaction in a continuous-flow reactor catalyzed by a highly reusable heterogeneous peptide

Otvos, S. B.; Mandity, I. M.; Fulop, F.; J. Cat., 2012, 295, 179-185

Link to article

Asymmetric hydrogenation of C=C double bonds using Rh-complex under homogeneous, heterogeneous and continuous mode conditions

Balogh S.; Farkas, G.; Madarasz, J.; Szollosy, A.; Kovacs, J.; Darvas, F.; Urge L.; Bakos, J.; Green Chem., 2012, 14, 1146-1151

Link to article

Asymmetric Mannich reaction of dicarbonyl compounds with α-amido sulfones catalyzed by cinchona alkaloids and synthesis of chiral dihydropyrimidones

Lou, S.; Dai, P.; Schaus, S. E.; J. Org. Chem., 2007, 72, 9998-10008

Link to article

Asymmetric organocatalytic Michael addition–cyclisation cascade of cyclopentane-1,2-dione with alkylidene malononitriles

Asymmetric Synthesis of γ-Amino-Functionalised Vinyl Sulfones: De Novo Preparation of Cysteine Protease Inhibitors

Asymmetric Synthesis of Trisubstituted Piperidines via Biocatalytic Transamination and Diastereoselective Enamine or Imine Reduction

Asymmetric Total Synthesis of (-)-Erogorgiaene and Its C-11 Epimer and Investigation of Their Antimycobacterial Activity

Atomic Cu on nanodiamond-based sp2/sp3 hybrid nanostructures for selective hydrogenation of phenylacetylene

Sun, Y.; Luo, B.; Xu, S.; Guo, W.; Huang, X.; Shao, L.; Chemical Physics Letters, 2019, 723, 39-43

Link to article

Automated and continuous synthesis of drug substances

Automated flow and real-time analytics approach for screening functional group tolerance in heterogeneous catalytic reactions

Automated technology for performing flow chemistry at elevated temperature and pressure

Kovacs, I.; Jones, R. V.; Niesz, K.; Csajagi, Cs.; Borcsek, B.; Darvas, F.; Urge, L.; JALA, 2007, 12, 284-290

Link to article

Autonomous continuous flow reactor synthesis for scalable atom-precision

Aziridine ring opening for the synthesis of sphingolipid analogues: Inhibitors of sphingolipid-metabolizing enzymes

Alcaide, A.; Llebaria, A.; J. Org. Chem., 2014, 79(7), 2993-3029

Link to article

Batch and continuous-flow room temperature furfural acetalization with ethanol over aluminophosphate (APAl) catalysts for biofuels production

Batch and flow hydrotreatment of water contaminated by trichloroethylene on active carbon supported nickel catalysts

Batch versus continuous flow performance of supported mono‐ and bimetallic nickel catalysts for catalytic transfer hydrogenation of furfural in isopropanol

Batch‐ and Continuous‐Flow Aerobic Oxidation of 14‐Hydroxy Opioids to 1,3‐Oxazolidines—A Concise Synthesis of Noroxymorphone

Benchmarking immobilized di- and triarylphosphine palladium catalysts for continuous-flow cross-coupling reactions: Efficiency, durability, and metal leaching studies

Greco, R.; Goessler, W.; Cantillo, D.; Kappe, C. O.; ACS Catal., 2015, 5, 1303-1312

Link to article

Benign-by-design orange peel-templated nanocatalysts for continuous flow conversion of levulinic acid to N-heterocycles

Benzo[d]imidazole transient receptor potential vanilloid 1 antagonists for the treatment of pain: Discovery of trans-2-(2-{2-[2-(4-trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

Parsons, W. H.; Calvo, R. R.; Cheung, W.; Lee, Y. K.; Patel, S.; Liu, J.; Youngman, M. A.; Dax, S. L.; Stone, D.; Qin, N.; Hutchinson, T.; Lubin, M. L.; Zhang, S. P.; Finley, M.; Liu, Y.; Brandt, M. R.; Flores, C. M.; Player, M. R.; J. Med. Chem., 2015, 58(9), 3859-3874

Link to article

Benzoxazinone synthesis via Passerini–Smiles couplings

Martinand-Lurin, E.; El Kaim, L.; Grimaud, L.; Tetrahedron Letters, 2014, 55(37), 5144-5146

Link to article

Benzoxazolone carboxamides as potent acid ceramidase inhibitors: Synthesis and structure–activity relationship (SAR) studies

Bach, A.; Pizzirani, D.; Realini, N.; Vozella, V.; Russo, D.; Penna, I.; Melzig, L.; Scarpelli, R.; Piomelli, D.; J. Med. Chem., 2015, 58(23), 9258-9272

Link to article

Beyond electrolysis: old challenges and new concepts of electricity-driven chemical reactors

Beyond the use of modifiers in selective alkyne hydrogenation: silver and gold nanocatalysts in flow mode for sustainable alkene production

Vile, G.; Perez-Ramirez, J.; Nanoscale, 2014, 6, 13476-13482

Link to article

Bicyclic naphthenic acids in oil sands process water: Identification by comprehensive multidimensional gas chromatography–mass spectrometry

Wilde, M. J.; West, C. E.; Scarlett, A. G.; Jones, D.; Frank, R. A.; Hewitt, L. M.; Rowland, S. J.; Journal of Chromatography A, 2015, 1378, 74-87

Link to article

Bifunctional Ruthenium Nanoparticle-SILP Catalysts (RuNPs@SILP) for the Hydrodeoxygenation of Eucalyptol under Batch and Continuous Flow Conditions

Biocatalyzed Flow Oxidation of Tyrosol to Hydroxytyrosol and Efficient Production of Their Acetate Esters

Bis(diethylamino)(pentafluorophenyl)phosphane – a push–pull phosphane available for coordination

Orthaber, A.; Fuchs, M.; Belaj, F.; Rechberger, G. N.; Kappe, C. O.; Pietschnig, R.; Eur. J. Inorg. Chem., 2011, 2588-2596

Link to article

Boosting the Productivity of H₂-Driven Biocatalysis in a Commercial Hydrogenation Flow Reactor Using H₂ From Water Electrolysis

Build−Couple−Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity

Building β-peptide H10/12 foldamer helices with six-membered cyclic side-chains: Fine-tuning of folding and self-assembly

Mandity, M. I.; Fulop, L.; Vass, E.; Toth; G. K.; Martinek, T. A.; Fulop, F.; Organic Letters, 2010, 12(23), 5584-5587

Link to article

C-3 epimers of sugar amino acids as foldameric building blocks: improved synthesis, useful derivatives, coupling strategies

Can two‐dimensional gas chromatography/mass spectrometric identification of bicyclic aromatic acids in petroleum fractions help to reveal further details of aromatic hydrocarbon biotransformation pathways?

West, C. E.; Pureveen, J.; Scarlett, A. G.; Lengger, S. K.; Wilde, M. J.; Korndorffer, F.; Tegelaar, E. W.; Rowland, S. J.; Rapid Commun. Mass Spectrom., 2014, 28(9), 1023-1032

Link to article

Carbonylation in microflow: close encounters of CO and reactive species

Catalysis in flow: Au-catalysed alkylation of amines by alcohols

Zotova, N.; Robert, F. J.; Kelsall, G. H.; Jessiman, A. S.; Hellgardt, K.; Hii, K. K.; Gree Chem., 2012, 14, 226-232

Link to article

Catalysis in flow: the practical and selective aerobic oxidation of alcohols to aldehydes and ketones

Zotova, N.; Hellgardt, K.; Kelsall, G. H.; Jessiman, A. S.; Hii, K. K.; Green Chem., 2010, 12, 2157-2163

Link to article

Catalytic asymmetric crotylation of aldehydes: Application in total synthesis of (−)‐elisabethadione

Catalytic epoxidation of cyclohexene with tert-butylhydroperoxide using an immobilized molybdenum catalyst

Morales-delaRosa, S.; Campos-Martin, J. M.; Terreros, P.; Fierro, J. L. G.; Topics in Catalysis, 2015, 58, 325-333

Link to article

Catalytic Hydrogenation of Nitrocyclohexane with CuCo/SiO2 Catalysts in Gas and Liquid Flow Reactors

Catalytic hydrogenolysis of substituted diaryl ethers by using ruthenium nanoparticles on an acidic supported ionic liquid phase (Ru@SILP-SO3H)

Rengshausen, S.; Etscheidt, F.; Großkurth, J.; Luska, K. L.; Bordet, A.; Leitner, W.; Synlett, 2019, 30(4), 405-412

Link to article

Catalytic oxidation of aqueous bioethanol: an efficient upgrade from batch to flow

Mostrou, S.; Sipocz, T.; Nagl, A.; Fodi, B.; Darvas, F.; Fottinger, K.; van Bokhoven, J. A.; React. Chem. Eng., 2018, 3, 781-789

Link to article

Catalytically sustainable, palladium-decorated graphene oxide monoliths for synthesis in flow

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

Gallagher, C. M.; Garri, C.; Cain, E. L.; Ang, K. K. H.; Wilson, C. G.; Chen, S.; Hearn, B. R.; Jaishankar, P.; Aranda-Diaz, A.; Arkin, M. R.; Renslo, A. R.; Walter, P.; eLife, 2016, 5, e:11878

Link to article

Characterization of dispersion effects on reaction optimization and scale-up for a packed bed flow hydrogenation reactor

Eschelbach, J. W.; Wernick, D.; Bryan, M. C.; Doherty, E. M.; Aust. J. Chem., 2013, 66, 165-171

Link to article

Chemical and bacterial reduction of azo-probes: monitoring a conformational change using fluorescence spectroscopy

Rattray, N. J. W.; Zalloum, W. A.; Mansell, D.; Latimer, J.; Jaffar, M.; Bichenkova, E. V.; Freeman, S.; Tetrahedron, 2013, 69, 2758-2766

Link to article

Chemical assembly systems: Layered control for divergent, continuous, multistep syntheses of active pharmaceutical ingredients

Ghislieri, D.; Gilmore, K.; Seeberger, P. H.; Angew. Chem. Int. Ed., 2014, 54(2), 678-682

Link to article

Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Rossetti, I.; Compagnoni, M.; Chemical Engineering Journal, 2016, 296, 56-70

Link to article

Chemical synthesis of β-D-ManNAc containing pentasaccharide repeating unit of the exopolysaccharide from Lactobacillus rhamnosus BIM B-1039 in the form of its p-methoxyphenyl glycoside

Chemical Synthesis of β‑L‑Rhamnose Containing the Pentasaccharide Repeating Unit of the O‑Specific Polysaccharide from a Halophilic Bacterium Halomonas ventosae RU5S2EL in the Form of Its 2‑Aminoethyl Glycoside

Chemical synthesis of a tetrasaccharide related to the exocellular polysaccharide from Rhodococcus sp. RHA1

Budhadev, D.; Mukhopadhyay, B.; Carbohydrate Research, 2014, 394, 26-31

Link to article

Chemical synthesis of the 4-amino-4,6-dideoxy-d-glucose containing pentasaccharide repeating unit of the O-specific polysaccharide from Aeromonas hydrophila strain K691 in the form of its 2-aminoethyl glycoside

Adak, A.; Mukhopadhyay, B.; Carbohydrate Research, 2019, 476, 1-7

Link to article

Chemical synthesis of the pentasaccharide related to the repeating unit of the O-Antigen from Salmonella enterica O4

Das, R.; Mukhopadhyay, B.; Journal of Carbohydrate Chemistry, 2015, 34(5), 247-262

Link to article

Chemical synthesis of the pentasaccharide repeating unit of the O-specific polysaccharide from Escherichia coli O132 in the form of its 2-aminoethyl glycoside

Chemical synthesis of the pentasaccharide repeating unit of the O-specific polysaccharide from Ruminococcus gnavus

Chemical synthesis of the rare D-Fuc3NAc containing tetrasaccharide repeating unit of the O-antigenic polysaccharide from E. coli O74

Chemistry of 3-carbonyl-2-methyl-4-oxo-4H-1-benzopyrans

Ghosh, C. K.; Chakraborty, A.; ARKIVOC, 2016, 2016(1), 111-149

Link to article

Chemistry of pyrrolizidine alkaloids revisited – semi-synthetic microwave and continuous-flow approaches toward Crotalaria-alkaloids

Martineza, S. T.; Pinto, A. C.; Glasnov, T.; Kappe, C. O.; Tetrahedron Letters, 2014, 55(30), 4181-4184

Link to article

Chemo-Catalyzed Pathways to Lactic Acid and Lactates

Chemo-enzymatic synthesis of 13C labeled complex N-glycans as internal standards for the absolute glycan quantification by mass spectrometry

Echeverria, B.; Etxebarria, J.; Ruiz, N.; Hernandez, A.; Calvo, J.; Haberger, M.; Reusch, D.; Reichardt, N-C.; Analytical Chemistry, 2015, 87(22), 11460-11467

Link to article

Chemoenzymatic Synthesis in Flow Reactors: A Rapid and Convenient Preparation of Captopril

Chemoselective flow hydrogenation approaches to diversify the cytotoxic tetrahydroepoxyisoindole carboxamide scaffold

Spare, L. K.; Harman, D. G.; Aldrich-Wright, J. R.; Nguyen, T. V.; Gordon, C. P.; Adv. Synth. Catal., 2018, 360(6), 1209-1217

Link to article

Chemoselective flow hydrogenation approaches to isoindole-7-carboxylic acids and 7-oxa-bicyclio[2.2.1]heptanes

Hizartzidis, L.; Tarleton, M.; Gordon, C. P.; McCluskey, A.; RSC Adv., 2014, 4, 9709-9722

Link to article

Chiral auxiliary recycling in continuous flow: automated recovery and reuse of Oppolzer’s sultam

Sullivan, R. J.; Newman, S. G.; Chemical Science, 2018, 9, 2130-2134

Link to article

Chitin-Derived Nanocatalysts for Reductive Amination Reactions

CIS is a potent checkpoint in NK cell–mediated tumor immunity

Co Loading Adjustment for the Effective Obtention of a Sedative Drug Precursor through Efficient Continuous-Flow Chemoselective Hydrogenation of 2-Methyl-2-Pentenal

Cobalt-doped magnesium fluoride as a support for platinum catalysts: The correlation of surface acidity with hydrogenation activity

Combining enabling techniques in organic synthesis: continuous flow process with heterogenized catalysts

Kirschning, A.; Solodenko, W.; Mennecke, K.; Chem. Eur. J., 2006, 12(23), 5972-5990

Link to article

Combining microfluidics and FT-IR spectroscopy: towards spatially resolved information on chemical processes

Comparative Study of Supported Monometallic Catalysts in the Liquid-Phase Hydrogenation of Furfural: Batch Versus Continuous Flow

Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling

Baer, S.; Nigro, J.; Madej, M. P.; Nisbet, R. M.; Suryadinata, R.; Coia, G.; Hong, L. P. T.; Adams, T. E.; Williams, C. C.; Nuttall, S. D.; Org. Biomol. Chem., 2014, 12, 2675-2685

Link to article

Concise chemical synthesis of the pentasaccharide repeating unit of the O-antigen from Escherichia albertii O2

Concise synthesis of a tetra- and a trisaccharide related to the repeating unit of the O-antigen from Providencia rustigianii O34 in the form of their p-methoxyphenyl glycosides

Verma, P. R.; Mukhopadhyay, B.; RSC Adv., 2013, 3, 201-207

Link to article

Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxidation

Chassagne, P.; Raibaut, L.; Guerreiro, C.; Mulard, L. A.; Tetrahedron, 2013, 69(48), 10337-10350

Link to article

Concise synthesis of the tetrasaccharide repeating unit of the O-antigen from Escherichia coli O131 containing N-acetyl neuraminic acid

Concise synthesis of the trisaccharide repeating unit of the O-polysaccharide from Aeromonas hydrophila A19 (O:14)

Pal, K. B.; Mukhopadhyay, B.; Carbohydrate Research, 2013, 379, 26-29

Link to article

Concise synthesis of vesnarinone and its analogues by using Pd‐catalyzed C–N bond‐forming reactions

See, Y. Y.; Dang, T. T.; Chen, A.; Seayad, A. M.; Eur. J. Org. Chem., 2014, 7405-7412

Link to article

Construction and validation of an automated flow hydrogenation instrument for application in high-throughput organic chemistry

Clapham, B.; Wilson, N. S.; Michmerhuizen, M. J.; Blanchard, D. P.; Dingle, D. M.; Nemcek, T. A.; Pan, J. Y.; Sauer, D. R.; J. Comb. Chem., 2008, 10, 88-93

Link to article

Construction of a bicyclic β-benzyloxy and β-hydroxy amide library through a multicomponent cyclization reaction

Zhang, L.; Xiao, Q.; Ma, C.; Xie, X.; Floreancig, P. E.; J. Comb. Chem., 2009, 11(4), 640-644

Link to article

Continuous enantioselective hydrogenation of activated ketones on a Pt-CD chiral catalyst: Use of H-Cube reactor system

Szollosi, G.; Herman, B.; Fulop, F.; Bartok, M.; React. Kinet. Catal. Lett., 2006, 88(2), 391-398

Link to article

Continuous enzymatic stirred tank reactor cascade with unconventional medium yielding high concentrations of (S)-2-hydroxyphenyl propanone and its derivatives

Continuous flow alcoholysis of furfuryl alcohol to alkyl levulinates using zeolites

Continuous flow biocatalysis

Continuous-flow biochemical reactors: Biocatalysis, bioconversion, and bioanalytical applications utilizing immobilized microfluidic enzyme reactors

Hajba, L.; Guttman, A.; J. Flow Chem., 2016, 6(1), 8-12

Link to article

Continuous-flow catalytic deuterodehalogenation carried out in propylene carbonate

Mandity, I. M.; Fulop, F.; Orsy, G.; Green Chemistry, 2019, 21, 956-961

Link to article

Continuous-flow catalytic hydrogenation of 3a,6-epoxyisoindoles

Zaytsev, V. P.; Zubkov, F. I.; Mertsalov, D. F.; Orlova, D. N.; Sorokina, E. A.; Nikitina, E. V.; Varlamov, A. V.; Russian Chemical Bulletin, 2015, 64, 112-126

Link to article

Continuous flow conversion of alkyl levulinates into γ-valerolactone in the presence of Ru/C as catalyst

Continuous flow conversion of biomass-derived methyl levulinate into γ-valerolactone using functional metal organic frameworks

Continuous-flow enzymatic resolution strategy for the acylation of amino alcohols with a remote stereogenic centre: synthesis of calycotomine enantiomers

Schonstein, L.; Forro, E.; Fulop, F.; Tetrahedron: Asymmetry, 2013, 24, 202-206

Link to article

Continuous flow fabrication of block copolymer–grafted silica micro‐particles in environmentally friendly water/ethanol media

Continuous-flow high pressure hydrogenation reactor for optimization and high-throughput synthesis

Jones, R. V.; Godorhazy, L.; Varga, N.; Szalay, D.; Urge, L.; Darvas, F.; J. Comb. Chem., 2006, 8(1), 110-116

Link to article

Continuous-flow hydrogenation of D-xylose with bimetallic ruthenium catalysts on micrometric alumina

Paun, C.; Lewin, E.; Sa, J.; iMedPub., 2017

Link to article

Continuous flow hydrogenation of functionalized pyridines

Irfan, M.; Petricci, E.; Glasnov, T. N.; Taddei, M.; Kappe, C. O.; Eur. J. Org. Chem., 2009, 9, 1327-1334

Link to article

Continuous flow hydrogenation of nitroarenes, azides and alkenes using maghemite–Pd nanocomposites

Rathi, A. K.; Gawande, M. B.; Ranc, V.; Pechousek, J.; Petr, M.; Cepe, K.; Varma, R. S.; Zboril, R.; Catal. Sci. Technol., 2016, 6, 152-160

Link to article

Continuous flow hydrogenation of nitroarenes, azides and alkenes using maghemite-Pd nanocomposites

Continuous-flow hydrogenation of nitrocyclohexane toward value-added products with CuZnAl hydrotalcite derived materials

Continuous-flow hydrogenation of olefins and nitrobenzenes catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

Osako, T.; Torii, K.; Tazawa, A.; Uozumi, Y.; RSC Adv., 2015, 5, 45760-45766

Link to article

Continuous flow hydrogenation with Pd complexes of pyridine-benzotriazole ligands

Continuous flow (micro-)reactors for heterogeneously catalyzed reactions: Main design and modelling issues

Continuous-flow microreactor chemistry under high-temperature/pressure conditions

Razzaq, T.; Glasnov, T. N.; Kappe, C. O.; Eur. J. Org. Chem., 2009, 9, 1321-1325

Link to article

Continuous flow multi-step organic synthesis

Webb, D.; Jamison, T. F.; Chemical Science, 2010, 6, 675-680

Link to article

Continuous flow nanocatalysis: reaction pathways in the conversion of levulinic acid to valuable chemicals

Bermudez, J. M.; Menendez, J. A.; Romero, A. A.; Serrano, E.; Garcia-Martinez, J.; Luque, R.; Green Chem., 2013, 15(10), 2786-2792

Link to article

Continuous flow organic chemistry: successes and pitfalls at the interface with current societal challenges

Gerardy, R.; Emmanuel, N.; Toupy, T.; Kassin, V-E.; Tshibalonza, N. N.; Schmitz, M.; Monbaliu, J-C. M.; Eur. J. Org. Chem., 2018, 2018(20-21), 2301-2351

Link to article

Continuous-flow organic synthesis: a tool for the modern medicinal chemist

Wiles, C.; Watts, P.; Future Med. Chem., 2009, 1(9), 1593-1612

Link to article

Continuous flow organic synthesis under high-temperature/pressure conditions

Razzaq, T.; Kappe, C. O.; Chem. Asian J., 2010, 5(6), 1274-1289

Link to article

Continuous flow ozonolysis in a laboratory scale reactor

Irfan, M.; Glasnov, T. N.; Kappe, C. O.; Organic Letters, 2011, 13(5), 984-987

Link to article

Continuous-flow Pd-catalyzed carbonylation of aryl chlorides with carbon monoxide at elevated temperature and pressure

Mata, A.; Hone, C. A.; Gutmann, B.; Moens, L.; Kappe, C. O.; ChemCatChem, 2018, 11(3), 997-1001

Link to article

Continuous-flow processes in heterogeneously catalyzed transformations of biomass derivatives into fuels and chemicals

Serrano-Ruiz, J. C.; Luque, R.; Campelo, J. M.; Romero, A. A.; Challenges, 2012, 3, 114-132

Link to article

Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients

de Souza, R. O. M. A.; Aguiar, R.; Leao, R. A. C.; Miranda, L. S. N.; Kappe, C. O.; Cantillo, D.; Mata, A.; Org. Biomol. Chem., 2019, 17, 1552-1557

Link to article

Continuous flow reactors: a perspective

Wiles, C.; Watts, P.; Green Chem., 2012, 14, 38-54

Link to article

Continuous flow Reductive Alkylation of Methanol by Aldehydes. Synthesis of O-Methyl Ethers and 1,1-Dimethoxyacetals

Continuous-flow reductive alkylation: synthesis of bio-based symmetrical and disymmetrical ethers

Bruniaux, S.; Luart, D.; Len, C.; Synthesis, 2018, 50, 1849-1856

Link to article

Continuous Flow retro-Diels-Alder Reaction: A Novel Process Window for Designing New Heterocyclic Scaffolds

Continuous flow room temperature reductive aqueous homo-coupling of aryl halides using supported Pd catalysts

Feiz, A.; Bazgir, A.; Balu, A. M.; Luque, R.; Sci. Rep., 2016, 6, Article number: 32719

Link to article

Continuous flow selective hydrogenation of 5-hydroxymethylfurfural to 2,5-dimethylfuran using highly active and stable Cu-Pd/reduced graphene oxide

Continuous-flow stereoselective reduction of prochiral ketones in a whole cell bioreactor with natural deep eutectic solvents

Continuous flow study of isoeugenol to vanillin: A bio-based iron oxide catalyst

Continuous-flow syntheses of heterocycles

Glasnov, T. N.; Kappe, C. O.; J. Heterocyclic Chem., 2011, 48, 11-30

Link to article

Continuous flow synthesis. A pharma perspective

Malet-Sanz, L.; Susanne, F.; J. Med. Chem., 2012, 55(9), 4062-4098

Link to article

Continuous flow synthesis of 6-monoamino-6-monodeoxy-β-cyclodextrin

Continuous Flow Synthesis of a Key 1,4-Benzoxazinone Intermediate via a Nitration/Hydrogenation/Cyclization Sequence

Continuous flow synthesis of amines from the cascade reactions of nitriles and carbonyl-containing compounds promoted by Pt-modified titania catalysts

Contiuous-flow synthesis of deuterium-labeled antidiabetic chalcones: studies towards the selective deuteration of the alkynone core

Otvos, S. B.; Hsieh, C. T.; Wu, Y. C.; Li, J. H.; Chang, F. R.; Fulop, F.; Molecules, 2016, 21(3), 318-329

Link to article

Continuous Flow Synthesis of High Valuable N-Heterocycles via Catalytic Conversion of Levulinic Acid

Continuous flow synthesis of menthol via tandem cyclisation-hydrogenation of citronellal catalysed by scrap catalytic converters

Continuous-flow synthesis of primary amines: Metal-free reduction of aliphatic and aromatic nitro derivatives with trichlorosilane

Continuous-flow synthesis of thermochromic M-Phase VO₂ particles via rapid one-step hydrothermal reaction: Effect of mixers

Continuous flow transfer hydrogenation of biomass derived methyl levulinate over Zr containing zeolites: Insights into the role of the catalyst acidity

Continuous reductive amination of biomass-derived molecules over carbonized filter paper-supported FeNi alloy

Chieffi, G.; Braun, M.; Esposito, D.; ChemSusChem, 2015, 8(21), 3590-3594

Link to article

Continuous‐flow hydrogenation and reductive deuteration of nitriles: a simple access to α,α‐dideutero amines

Controlled photo-flow oxidative reaction (UV-FOR) platform for ultra-fast phthalides and API synthesis

Convergent synthesis of the hexasaccharide related to the repeating unit of the O-antigen from E. coli O120

Budhadev, D.; Mukhopadhyay, B.; RSC Adv., 2015, 5, 98033-98040

Link to article

Convergent synthesis of the hexasaccharide repeating unit of the O-antigenic OPS of Escherichia coli O133

Copper-catalyzed rearragement of oximes into primary amides

Sharma, S. K.; Bishopp, S. D.; Allen, C. L.; Lawrence, R.; Bamford, M. J.; Lapkin, A. A.; Plucinski, P.; Watson, R. J.; Williams, J. M .J.; Tetrahedron Letters, 2011, 52, 4252-4255

Link to article

Copper-zinc oxide interface as a methanol-selective structure in Cu-ZnO catalyst during catalytic hydrogenation of carbon dioxide to methanol

Covalently immobilized Trp60Cys mutant of ω-transaminase from Chromobacterium violaceum for kinetic resolution of racemic amines in batch and continuous-flow modes

Cross-coupling in flow

Noel, T.; Buchwald, S. L.; Chem. Soc. Rev., 2011, 40, 5010-5029

Link to article

Cubanes in medicinal chemistry: Synthesis of functionalized building blocks

Wlochal, J.; Davies, R. D. M.; Burton, J.; Org. Lett., 2014, 16, 4094-4097

Link to article

De novo design of a picomolar nonbasic 5-HT1B receptor antagonist

Nugiel, D. A.; Krumrine, J. R.; Hill, D. C.; Damewood, J. R.; Bernstein, P. R.; Sobotka-Briner, C. D.; Liu, J. W.; Zacco, A.; Pierson, M. E.; J. Med. Chem., 2010, 53, 1876-1880

Link to article

De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments

Urich, R.; Wishart, G.; Kiczun, M.; Richters, A.; Tidten-Luksch, N.; Rauh, D.; Sherborne, B.; Wyatt, P. G.; Brenk, R.; ACS Chem. Biol., 2013, 8(5), 1044-1052

Link to article

De novo design, synthesis and pharmacological evaluation of new azaindole derivatives as dual inhibitors of Abl and Src kinases

Cheve, G.; Bories, C.; Fauvel, B.; Picot, F.; Tible, A.; Dayde-Cazals, B.; Loget, O.; Yasri, A.; Med. Chem. Commun., 2012, 3, 788-800

Link to article

Densely substituted L-proline esters as catalysts for asymmetric Michael additions of ketones to nitroalkenes

Ruiz-Olalla, A.; de Gracia Retamosa, M.; Cossio, F. P.; J. Org. Chem., 2015, 80(11), 5588-5599

Link to article

Design and development of Pd-catalyzed aerobic N-demethylation strategies for the synthesis of noroxymorphone in continuous flow mode

Gutmann, B.; Cantillo, D.; Weigl, U.; Cox, P.; Kappe, C. O.; Eur. J. Org. Chem., 2017, 914-927

Link to article

Design and development of photoswitchable DFG-Out RET kinase inhibitors

Design and Scaling Up of Microchemical Systems: A Review

Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist

Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119

Darout, E.; Robinson, R. P.; McClure, K. F.; Corbett, M.; Li, B.; Shavnya, A.; Andrews, M. P.; Jones, C. S.; Li, Q.; Minich, L. M.; Mascitti, V.; Guimaraes, C. R. W.; Munchhof, M. J.; Bahnck, K. B.; Cai, C.; Price, D. A.; Liras, S.; Bonin, P. D.; Cornelius, P.; Wang, R.; Bagdasarian, V.; Sobota, C. P.; Hornby, S.; Masterson, V. M.; Joseph, R. M.; Kalgutkar, A. S.; Chen, Y.; J. Med. Chem., 2013, 56, 301-319

Link to article

Design and synthesis of multivalent α-1,2-trimannose-linked bioerodible microparticles for applications in immune response studies of Leishmania major infection

Rintelmann, C. R.; Grinnage-Pulley, T.; Ross, K.; Kabotso, D. E. K.; Toepp, A.; Cowell, A.; Petersen, C.; Narasimhan, B.; Pohl, N.; Beilstein J. Org. Chem., 2019, 15, 623-632

Link to article

Design of a highly selective and potent class of non-planar estrogen receptor ß agonists

Sunden, H.; Ma, J. N.; Hansen, L. K.; Gustavsson, A. L.; Burstein, E. S.; Olsson, R.; ChemMedChem, 2013, 8(8), 1283-1294

Link to article

Design of experiments (DoE) and process optimization. A review of recent publications

Weissman, S. A.; Anderson, N. G.; Org. Process Res. Dev., 2015, 19(11), 1605-1633

Link to article

Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists

Cho, K.; Ando, M.; Kobayashi, K.; Miyazoe, H.; Tsujino, T.; Ito, S.; Suzuki, T.; Tanaka, T.; Tokita, S.; Sato, N.; Bioorg. Med. Chem. Lett., 2009, 19(16), 4781-4785

Link to article

Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators

Pettersson, M.; Johnson, D. S.; Subramanyam, C.; Bales, K. R.; am Ende, C. W.; Fish, B. A.; Green, M. E.; Kauffman, G. W.; Mullins, P. B.; Navaratnam, T.; Sakya, S. M.; Stiff, C. M.; Tran, T. P.; Xie, L.; Zhang, L.; Pustilnik, L. R.; Vetelino, B. C.; Wood, K. M.; Pozdnyakov, N.; Verhoest, P. R.; O'Donnell, C. J.; J. Med. Chem., 2014, 57, 1046-1062

Link to article

Deuterated Liquid Crystals – design and synthesis of deuterium labelled 4,4ʺ-dialkyl-2′,3′-difluoro-[1,1′:4′,1ʺ]terphenyls using batch and continuous flow systems

Development of biolubricants from vegetable oils via chemical modification

McNutt, J.; He, Q.; J. Ind. Eng. Chem., 2016, 36, 1-12

Link to article

Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors

Lawrence, H. R.; Martin, M. P.; Luo, Y.; Pireddu, R.; Yang, H.; Gevariya, H.; Ozcan, S.; Zhu, J. Y.; Kendig, R.; Rodriguez, M.; Elias, R.; Cheng, J. Q.; Sebti, S. M.; Schonbrunn, E.; Lawrence, N. J.; J. Med. Chem., 2012, 55(17), 7392-7416

Link to article

Development of second-generation indole-based dynamin GTPase inhibitors

Gordon, C. P.; Venn-Brown, B.; Robertson, M. J.; Young, K. A.; Chau, N.; Mariana, A.; Whiting, A.; Chircop, M.; Robinson, P. J.; McCluskey, A.; J. Med. Chem., 2013, 56, 46-59

Link to article

Diacylglycerol synthesis by lipase-catalyzed partial hydrolysis of palm oil under microwave irradiation and continuous flow conditions

Matos, L. M. C.; Leal, I. C. R.; de Souza, R. O. M. A.; Journal of Molecular Catalysis B: Enzymatic, 2011, 72, 36-39

Link to article

Diastereoselective 1,3-dipolar cycloaddition of pyrylium ylides with chiral enamides

Tchabanenko, K.; Sloan, C.; Bunetel, Y.; Mullen, P.; Org. Bioorg. Chem., 2012, 10, 4215-4219

Link to article

Diastereoselective [2,3]-sigmatropic rearrangement of N-allyl ammonium ylides

Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assembly

Carter, C. F.; Lange, H.; Sakai, D.; Baxendale I. R.; Ley, S. V.; Chem. Eur. J., 2011, 17, 3398-3405

Link to article

Diastereoselective synthesis of cis-N-Boc-4-aminocyclohexanol with reductive ring opening method using continuous flow

Szabo, B.; Tamas, B.; Faigl, F.; Eles, J.; Greiner, I.; J. Flow Chem., 2019, 9(1), 13-17

Link to article

Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars

Bergeron-Brlek, M.; Meanwell, M.; Britton, R.; Nature Communications, 2015, 6, 6303

Link to article

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Z.; Pinson, J. A.; Mountford, S. J.; Orive, S.; Schoenwaelder, S. M.; Shackleford, D.; Powell, A.; Nelson, E. M.; Hamilton, J. R.; Jackson, S. P.; Jennings, I. G.; Thompson, P. E.; Eur. J. Med. Chem., 2016, 122, 339-351

Link to article

Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase

Cummings, M. D.; Lin, T.; Hu, L.; Tahri, A.; McDowan, D.; Amssoms, K.; Last, S.; Devogelaere, B., Rouan, M.; Vijgen, L., Berke, J. M.; Dehertogh, P.; Fransen, E.; Cleiren, E.; van der Helm, L.; Fanning, G.; Nyanguile, O.; Simmen, K.; Remoortere, P. V.; Raboisson, P.; Vendeville, S., J. Med. Chem., 2014, 57(5), 1880-1892

Link to article

Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design

Efremov, I. V.; Vajdos, F. F.; Borzilleri, K. A.; Capetta, S.; Chen, H.; Dorff, P. H.; Dutra, J. K.; Goldstein, S. W.; Mansour, M.; McColl, A.; Noell, S.; Oborski, C. E.; O'Connell, T. N.; O'Sullivan, T. J.; Pandit, J.; Wang, H.; Wei, B.; Withka, J. M.; J. Med. Chem., 2012, 55(21), 9069-9088

Link to article

Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2

Zak, M.; Mendonca, R.; Balazs, M.; Barrett, K.; Bergeron, P.; Blair, W. S.; Chang, C.; Deshmukh, G.; DeVoss, J.; Dragovich, P. S.; Eigenbrot, C.; Ghilardi, N.; Gibbons, P.; Gradl, S.; Hamman, C.; Hanan, E.; Harstad, E.; Hewitt, P. R.; Hurley, C. A.; Jin, T.; Johnson, A.; Johnson, T.; Kenny, J. R.; Koehler, M. F. T.; Kohli, P. B.; Kulagowski, J.; Labadie, S.; Liao, J.; Liimatta, M.; Lin, Z.; Lupardus, P. J.; Maxey, R. J.; Murray, J. M.; Pulk, R.; Rodriguez, M.; Savage, S.; Shia, S.; Steffek, M.; Ubhayakar, S.; Ultsch, M.; Van-Abbema, A.; Ward, S.; Xiao, L.; Xiao, Y.; J. Med. Chem., 2012, 55(13), 6176-6193

Link to article

Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization

Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

Phillipson, L. J.; Segal, D. H.; Nero, T. L.; Parker, M. W.; Wan, S. S.; de Silva, M.; Guthridge, M. A.; Wei, A. H.; Burns, C. J.; Bioorg. Med. Chem., 2015, 23(19), 6280-6296

Link to article

Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)

Martin-Martin, M. L.; Bartolome-Nebreda, J. M.; Conde-Ceide, S.; Alonso de Diego, S. A.; Lopez, S.; Martinez-Viturro, C. M.; Tong, H. M.; Lavreysen, H.; Macdonald, G. J.; Steckler, T.; Mackie, C.; Bridges, T. M.; Daniels, J. S.; Niswender, C. M.; Noetzel, M. J.; Jones, C. K.; Conn, P. J.; Lindsley, C. W.; Stauffer, S. R.; Bioorg. Med. Chem. Lett., 2015, 25(6), 1310-1317

Link to article

Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors

Ge, Y.; Kazi, A.; Marsilio, F.; Luo, Y.; Jain. S.; Brooks, W.; Daniel, K. G.; Guida, W. C.; Sebti, S. M.; Lawrence, H. R.; J. Med. Chem., 2012, 55(5), 1978-1998

Link to article

Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation

Giordanetto, F.; Wallberg, A.; Cassel, J.; Ghosal, S.; Kossenjans, M.; Yuan, Z. Q.; Wang, X.; Liang, L.; Bioorg. Med. Chem. Lett., 2012, 22, 6665-6670

Link to article

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)

Axten, J. M.; Medina, J. R.; Feng, Y.; Shu, A.; Romeril, S. P.; Grant, S. W.; Li, W. H. H.; Heerding, D. A.; Minthorn, E.; Mencken, T.; Atkins, C.; Liu, Q.; Rabindran, S.; Kumar, R.; Hong, X.; Goetz, A.; Stanley, T.; Taylor, J. D.; Sigethy, S. D.; Tomberlin, G. H.; Hassell, A. M.; Kahler, K. M.; Shewchuk, L. M.; Gampe, R. T.; J. Med. Chem., 2012, 55(16), 7193-7207

Link to article

Discovery of a new class of highly potent inhibitors of acid ceramidase: Synthesis and structure–activity relationship (SAR)

Pizzirani, D.; Pagliuca, C.; Realini, N.; Branduardi, D.; Bottegoni, G.; Mor, M.; Bertozzi, F.; Scarpelli, R.; Piomelli, D.; Bandiera, T.; J. Med. Chem., 2013, 56(9), 3518-3530

Link to article

Discovery of a novel chemotype of histone lysine methyltransferase EHMT1/2 (GLP/G9a) inhibitors: rational design, synthesis, biological evaluation and cocrystal structure

Milite, C.; Feoli, A.; Horton, J. R.; Rescigno, D.; Cipriano, A.; Pisapia, V.; Viviano, M.; Pepe, G.; Amendola, G.; Novellino, E.; Cosconati, S.; Cheng, X.; Castellano, S.; Sbardella, G.; J. Med. Chem., 2019, 62(5), 2666-2689

Link to article

Discovery of a novel inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) as orally active antitumor agent

Vianello, P.; Botrugno, O. A.; Cappa, A.; Zuffo, R. D.; Dessanti, P.; Mai, A.; Marrocco, B.; Mattevi, A.; Meroni, G.; Minucci, S.; Stazi, G.; Thaler, F.; Trifiro, P.; Valente, S.; Villa, M.; Mercurio, C.; J. Med. Chem., 2016, 59(4), 1501-1517

Link to article

Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists

Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours

Barlaam, B.; Cosulich, S.; Degorce, S.; Ellston, R.; Fitzek, M.; Green, S.; Hancox, U.; Lambert-van der Brempt, C.; Lohmann, J-J.; Maudet, M.; Morgentin, M.; Ple, P.; Ward, L.; Warin, N.; Bioorg. Med. Chem. Lett., 2017, 27(9), 1949-1954

Link to article

Discovery of acrylonitrile-based small molecules active against Haemonchus contortus

Gordon, C. P.; Hizartzidis, L.; Tarleton, M.; Sakoff, J. A.; Gilbert, J.; Campbell, B. E.; Gasser, R. B.; McCluskey, A.; Med. Chem. Commun., 2014, 5, 159-164

Link to article

Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models

Patel, S.; Cohen, F.; Dean, B. J.; De La Torre, K.; Deshmukh, G.; Estrada, A. A.; Ghosh, A. S.; Gibbons, P.; Gustafson, A.; Huestis, M. P.; Le Pichon, C. E.; Lin, H.; Liu, W.; Liu, X.; Liu, Y.; Ly, C. Q.; Lyssikatos, J. P.; Ma, C.; Scearce-Levie, K.; Shin, Y. G.; Solanoy, H.; Stark, K. L.; Wang, J.; Wang, B:; Zhao, X.; Lewcock, J. W.; Siu, M.; J. Med. Chem., 2015, 58(1), 401-418

Link to article

Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor

Giordanetto, F.; Wallberg, A.; Knerr, L.; Selmi, N.; Ullah, V.; Thorstensson, F.; Lindelof, L.; Karlsson, S.; Nikitidis, G.; Llinas, A.; Wang, Q. D.; Lindqvist, A.; Hogberg, L.; Lindhardt, E.; Astrand, A.; Duker, G.; Bioorg. Med. Chem. Lett., 2013, 23(1), 119-124

Link to article

Discovery of narrow spectrum kinase inhibitors: New therapeutic agents for the treatment of COPD and steroid-resistant asthma

Onions, S. T.; Ito, K; Charron, C. E.; Brown, R. J.; Colucci, M.; Frickel, F.; Hardy, G.; Joly, K.; King-Underwood, J.; Kizawa, Y.; Knowles, I.; Murray, P. J.; Novak, A.; Rani, A.; Rapeport, G.; Smith, A.; Strong, P.; Taddei, D. M.; Williams, J. G.; J. Med. Chem., 2016, 59(5), 1727-1746

Link to article

Discovery of potent and selective inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) protein kinase as potential anticancer agents

Charrier, J. D.; Durrant, S. J.; Golec, J. M. C.; Kay, D. P., Knegtel, R. M. A.; MacCormick, S.; Mortimore, M.; O'Donnell, M. E.; Pinder, J. L.; Reaper, P. M.; Rutherford, A. P.; Wang, P. S. H.; Young, S. C.; Pollard, J. R.; J. Med. Chem., 2011, 54(7), 2320-2330

Link to article

Discovery of potent and selective reversible Bruton’s tyrosine kinase inhibitors

Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux

Rzasa, R. M.; Hu, E.; Rumfelt, S.; Chen, N.; Andrews, K. L.; Chmait, S.; Falsey, J. R.; Zhong, W.; Jones, A. D.; Porter, A.; Louie, S. W.; Zhao, X.; Treanor, J. J. S.; Allen, J. R.; Bioorg. Med. Chem. Lett., 2012, 22, 7371-7375

Link to article

Discovery of tertiary amine and indole derivatives as potent RORγt inverse agonists

Dissection of complex molecular recognition interfaces

Hunter, C. A.; Misuraca, M. C.; Turega, S. M.; J. Am. Chem. Soc., 2011, 133(3), 582-594

Link to article

Disubstituted 1-aryl-4-aminopiperidine library synthesis using computational drug design and high-throughput batch and flow technologies

Bryan, M. C.; Hein, C. D.; Gao, H.; Xia, X.; Eastwood, H.; Bruenner, B. A.; Louie, S. W.; Doherty, E. M; ACS Comb. Sci., 2013, 15(9), 503-511

Link to article

Diversity-oriented synthesis of a library of star-shaped 2H-imidazolines

Yu, X.; Guttenberger, N.; Fuchs, E.; Peters, M.; Weber, H.; Breinbauer R.; ACS Comb. Sci., 2015, 17(11), 682-690

Link to article

Diversity-oriented synthesis of dibenzoazocines and dibenzoazepines via a microwave-assisted intramolecular A3-coupling reaction

Bariwal, J. B.; Ermolat'ev, D. S.; Glasnov, T. N.; Van Hecke, K.; Mehta, V. P.; Van Meervelt, L.; Kappe, C. O.; Van der Eycken, E. V.; Org. Lett., 2010, 12(12), 2774-2777

Link to article

Doping carbon networks with phosphorus for supporting Pd in catalyzing selective oxidation of benzyl alcohol

Guo, W.; Niu, S.; Ji, X.; Yu, W.; Lin, T-W.; Wu, Y.; Li, Y.; Shao, L.; J. Nanopart. Res.; 2018, 20:180

Link to article

Double carbonylation of iodobenzene in a microfluidics-based high throughput flow reactor

Balogh, J.; Kuik, A.; Urge, L.; Darvas, F.; Bakos, J.; Skoda-Foldes, R.; Journal of Molecular Catalysis A: Chemical, 2009, 302, 76-79

Link to article

Easy access to Ni3N- and Ni-carbon nanocomposite catalysts

Clavel, G.; Molinari, V.; Kraupner, A.; Giordano, C.; Chem. Eur. J., 2014, 20(29), 9018-9023

Link to article

Eco-efficiency analysis for intensified production of an active pharmaceutical ingredient: a case study

Dencic, I.; Ott, D.; Kralisch, D.; Noel, T.; Meuldijk, J.; de Croon, M.; Hessel, V.; Laribi, Y.; Perrichon, P.; Org. Process Res. Dev., 2014, 18(11), 1326-1338

Link to article

Effect of Binding Linkers on the Efficiency and Metabolite Profile of Biomimetic Reactions Catalyzed by Immobilized Metalloporphyrin

Effects of Regioisomerism on the Antiproliferative Activity of Hydroxystearic Acids on Human Cancer Cell Lines

Efficient and scalable synthesis of thiazole fused benzazepine as a D2 partial agonist

Xiong, H.; Wu, Y.; Lehr, S. G.; Blackwell, W.; Steelman, G.; Hulsizer, J.; Urbanek, R. A.; Tetrahedron Letters, 2012, 53(44), 5833-5836

Link to article

Efficient Chemo-Enzymatic Flow Synthesis of High Value Amides and Esters

Efficient continuous-flow synthesis of novel 1,2,3-triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production

Otvos, S. B.; Georgiades, A.; Mandity, I. M.; Kiss, L.; Fulop, F.; Beilstein J. Org. Chem., 2013, 9, 1508-1516

Link to article

Efficient Ru-based scrap waste automotive converter catalysts for the continuous-flow selective hydrogenation of cinnamaldehyde

Electrochemical Hydroxylation of Electron-Rich Arenes in Continuous Flow

Electrochemical phenylselenoetherification as a key step in the synthesis of (±)-curcumene ether

Stevanovic, D.; Pejovic, A.; Damljanovic, I. S.; Vukicevic, M. D.; Dobrikov, G.; Dimitrov, V.; Denic, M. S.; Radulovic, N. S.; Vukicevic, R. D.; Helvetica Chimica Acta, 2013, 96(6), 1103-1110

Link to article

Electrophile-induced dearomatizing spirocyclization of N-arylisonicotinamides: A route to spirocyclic piperidines

Arnott, G.; Brice, H.; Clayden, J.; Blaney, E.; Organic Letters, 2008, 10(14), 3089-3092

Link to article

Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4)

Day, J. P.; Lindsay, B.; Riddel, T.; Jiang, Z.; Allock, R. W.; Abraham, A.; Sookup, S.; Christian, F.; Bogum, J.; Martin, E. K.; Rae, R. L.; Anthony, D.; Rosair, G. M.; Houslay, D. M.; Huston, E.; Baillie, G. S.; Klussmann, E.; Houslay, M. D.; Adams, D. R.; J. Med. Chem., 2011, 54(9), 3331-3347

Link to article

Emerging trends in flow chemistry and applications to the pharmaceutical industry

Bogdan, A. R.; Dombrowski, A. W.; J. Med. Chem., 2019, 62(14), 6422-6468

Link to article

Enabling the scale-up of a key asymmetric hydrogenation step in the synthesis of an API using continuous flow solid-supported catalysis

Amara, Z.; Poliakoff, M.; Duque, R.; Geier, D.; Francio, G.; Gordon, C. M.; Meadows, R. E.; Woodward, R.; Leitner, W.; Org. Process Res. Dev., 2016, 20, 1321-1327

Link to article

Enantiodivergent synthesis of bis-spiropyrrolidines via sequential interrupted and completed (3+2) cycloadditions

Conde, E.; Rivilla, I.; Larumbe, A.; Cossio F. P.; J. Org. Chem., 2015, 80(23), 11755-11767

Link to article

Enantiomer selective acylation of racemic alcohols by lipases in continuous-flow bioreactors

Csajagi, Cs.; Szatzker, G.; Toke, E. R.; Urge, L.; Darvas, F.; Poppe, L.; Tetrahedron: Asymmetry, 2008, 19(2), 237-246

Link to article

Enantiomeric separation of bicyclo[2.2.2]octane‐based 2‐amino‐3‐carboxylic acids on macrocyclic glycopeptide chiral stationary phases

Pataj, Z.; Ilisz, I.; Grecso, N; Palko, M.; Fulop, F.; Armstrong, D. W.; Peter, A.; Chirality, 2014, 26, 200-208

Link to article

Enantioselective access to benzannulated spiroketals using a chiral sulfoxide auxiliary

Aitken, H. R. M.; Furkert, D. P.; Hubert, J. G.; Wood, J. M.; Brimble, M. A.; Org. Biomol. Chem., 2013, 11, 5147-5155

Link to article

Enantioselective hydrogenation of α,β-unsaturated carboxylic acids in fixed-bed reactor

Herman, B.; Szollosi, G.; Fulop F.; Bartok, M.; Applied Catalysis A: General, 2007, 331, 39-43

Link to article

Enantioselective hydrolysis of 3,4-disubstituted β-lactams. An efficient enzymatic method for the preparation of a key Taxol side-chain intermediate

Galla, Zs.; Beke, F.; Forro, E.; Fulop, F.; Journal of Molecular Catalysis B: Enzymatic, 2016, 123, 107-112

Link to article

Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary

Jones, A. L.; Liu, X.; Snyder, J. K.; Tetrahedron Letters, 2010, 51(7), 1091-1094

Link to article

Enantioselective synthesis of bicyclo[2.2.2]octenones using a copper-mediated oxidative dearomatization/[4+2] dimerization cascade

Dong, S.; Zhu, J.; Porco, J. A.; J. Am. Chem. Soc., 2008, 130(9), 2738-2739

Link to article

Enantioselective synthesis of (+)-Chamaecypanone C: A novel microtubule inhibitor

Dong, S.; Hamel, E.; Bai, R.; Covell, D. G.; Beutler, J. A.; Porco, J .A.; Angew. Chem. Int. Ed., 2009, 48(8), 1494-1497

Link to article

End functionalization of polyisoprene and polymyrcene obtained by anionic polymerization via one-pot ring-opening mono-addition of epoxides

endo-Hydroxamic acid monomers for the assembly of a suite of non-native dimeric macrocyclic siderophores using metal-templated synthesis

Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction

Liu, Q.; Wu, K.; Cheng, Y.; Lu, L.; Xiao, E.; Zhang, Y.; Deng, Z.; Liu, T.; Metabolic Engineering, 2015, 28, 82-90

Link to article

Enhanced biocatalytic performance of bacterial laccase from Streptomyces sviceus: Application in the Michael addition sequence towards 3‐arylated 4‐oxochromanes

Suljic, S.; Mortzfeld, F. B.; Gunne, M.; Urlacher, V. B.; Pietruszka, J.; ChemCatChem, 2015, 7(8), 1380-1385

Link to article

Environmentally friendly synthesis of indoline derivatives using flow-chemistry techniques

Orkenyi, R.; Beke, G.; Riethmuller, E.; Szakacs, Z.; Koti, J.; Faigl, F.; Eles, J.; Greiner, I.; Eur. J. Org. Chem., 2017, 6525-6532

Link to article

Enzymatic reactions for the preparation of homocalycotomine enantiomers

Schonstein, L.; Forro, E.; Fulop, F.; Tetrahedron: Asymmetry, 2013, 24, 1059-1062

Link to article

Enzymatic strategy for the resolution of new 1‐hydroxymethyl tetrahydro‐β‐carboline derivatives in batch and continuous‐flow systems

Megyesi, R.; Forro, E.; Fulop, F.; ChemistryOpen, 2016, 5(3), 254-260

Link to article

Epoxy resin monomers with reduced skin sensitizing potency

O'Boyle, N. M.; Niklasson, I. B.; Tehrani-Bagha, A. R.; Delaine, T.; Holmberg, K.; Luthman, K.; Karlberg, A. T.; Chem. Res. Toxicol., 2014, 27(6), 1002-1010

Link to article

Evaluating dynamic kinetic resolution strategies in the asymmetric hydrosilylation of cyclic ketimines

Jones, S.; Zhao, P.; Tetrahedron: Asymmetry, 2014, 25(3), 238-244

Link to article

Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis

Bryan, M. C.; Wernick, D.; Hein, C. D.; Petersen, J. V.; Eschelbach, J. W.; Doherty, E. M.; Beilstein J. Org. Chem., 2011, 7, 1141-1149

Link to article

Evaluation of bifunctional chiral phosphine oxide catalysts for the asymmetric hydrosilylation of ketimines

Evaluation of functional groups as acetyl-lysine mimetics for BET bromodomain inhibition

Sharp, P. P.; Garnier, J-M.; Huang, D. C. S.; Burns, C. J.; MedChemCommun, 2014, 5, 1834-1842

Link to article

Evaluation of SILP-Pd catalysts for Heck reactions in amicrofluidics-based high throughput flow reactor

Urban, B.; Sranko, D.; Safran, G.; Urge, L.; Darvas, F.; Bakos, J.; Skoda-Foldes, R.; Journal of Molecular Catalysis A: Chemical, 2014, 395, 364-372

Link to article

Excellent antimicrobial and photocatalytic performance of C/GO/TiO₂/Ag and C/TiO₂/Ag hybrid nanocomposite beds against waterborne microorganisms

Expanding the toolbox of asymmetric organocatalysis by continuous-flow process

Finelli, F. G.; Miranda, L. S. M.; de Souza, R. O. M. A.; Chem. Commun., 2015, 51, 3708-3722

Link to article

Expanding the utility of flow hydrogenation – a robust protocol restricting hydrodehalogenation

Hizartzidis, L.; Cossar, P. J.; Robertson, M. J.; Simone, M. I.; Young, K. A.; McCluskey, A.; Gordon, C. P.; RSC Adv., 2014, 4, 56743-56748

Link to article

Expedient Diels–Alder cycloadditions with ortho-quinodimethanes in a high temperature/pressure flow reactor

Tsoung, J.; Wang, Y.; Djuric, S. W.; React. Chem. Eng., 2017, 2, 458-461

Link to article

Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a]pyridine: expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines

Bazin, M. A.; Marhadour, S.; Tonnerre, A.; Marchand, P.; Tetrahedron Letters, 2013, 54(39), 5378-5382

Link to article

Facile access to new C-glycosides and C-glycoside scaffolds incorporating functionalised aromatic moieties

Redpath, P.; Ness, K. A.; Rousseau, J.; Macdonald, S. J. F.; Migaud, M. E.; Carbohydrate Research, 2015, 402, 25-34

Link to article

Facile arene hydrogenation under flow conditions catalyzed by rhodium or ruthenium on carbon

Facile conversion of red phosphorus into soluble polyphosphide anions by reaction with potassium ethoxide

Dragulescu-Andrasi, A.; Miller, L. Z.; Chen, B.; McQuade, D. T.; Shatruk M.; Angew. Chem. Int. Ed., 2016, 55(12), 3904-3908

Link to article

Fast continuous alcohol amination employing a hydrogen borrowing protocol

Labes, R.; Mateos, C., Battilocchio, C.; Chen, Y.; Dingwall, P.; Cumming, G. R.; Rincon, J. A.; Nieves-Remacha, M. J.; Ley, S. V.; Green Chemistry, 2019, 21, 59-63

Link to article

Fatty acids residue from palm oil refining process as feedstock for lipase catalyzed monoacylglicerol production under batch and continuous flow conditions

Junior, I. I.; Flores, M. C.; Sutili, F. K.; Leite, S. G. F.; de M. e Miranda, L. S.; Leal, I. C. R.; de Souza, R. O. M. A.; Journal of Molecular Catalysis B: Enzymatic, 2012, 77, 53-58

Link to article

Features of oxa-bridge cleavage in hexahydro-3a,6-epoxyisoindol-1(4H)-ones: A concise method to access acetylisoindolones possessing anti-viral activity

Feedback in Flow for Accelerated Reaction Development

FeNi nanoparticles with carbon armor as sustainable hydrogenation catalysts: towards biorefineries

Chieffi, G.; Giordano, C.; Antonietti, M.; Esposito, D.; Journal of Materials Chemistry A, 2014, 2, 11591-11596

Link to article

Fine chemical syntheses under flow using SiliaCat catalysts

Ciriminna, R.; Pandarus, V.; Beland, F.; Pagliaro, M.; Catal. Sci. Technol., 2016, 6(13), 4678-4685

Link to article

First enantioselective total synthesis of (+)-(R)-pinnatolide using an symmetric domino allylation reaction

Tietze, L. F.; Wolfram, T.; Holstein, J. J.; Dittrich, B.; Org. Lett., 2012, 14(16), 4035-4037

Link to article

First example of alkyl–aryl Negishi cross-coupling in flow: Mild, efficient and clean introduction of functionalized alkyl groups

Egle, B.; Munoz, J.; Alonso, N.; De Borggraeve, W. M., de la Hoz, A.; Diaz-Ortiz, A.; Alcazar, J.; J. Flow Chem., 2014, 4(1), 22-25

Link to article

Fixed Bed Continuous Hydrogenations in Trickle Flow Mode: A Pharmaceutical Industry Perspective

Flash carboxylation: fast lithiation-carboxylation sequence at room temperature in continuous flow

Pieber, B.; Glasnov, T.; Kappe, C. O.; RSC Adv., 2014, 4, 13430-13433

Link to article

Flash flow pyrolysis: Mimicking flash vacuum pyrolysis in a high-temperature/high-pressure liquid-phase microreactor environment

Cantillo, D.; Sheibani, H.; Kappe, C. O.; J. Org. Chem., 2012, 77(5), 2463-2473

Link to article

Flow chemistry – A key enabling technology for (multistep) organic synthesis

Wegner, J.; Ceylan, S.; Kirschning, A.; Adv. Synth. Catal., 2012, 354, 17-57

Link to article

Flow chemistry approach for partial deuteration of alkynes: synthesis of deuterated taxol side chain

Chandrasekhar, S.; Vijaykumar, B. V. D.; Mahesh Chandra, B.; Raji Reddy, Ch.; Naresh, P.; Tetrahedron Letters, 2011, 52, 3865-3867

Link to article

Flow chemistry approaches directed at improving chemical synthesis

Baxendale, I. R.; Brocken, L.; Mallia, C. J.; Green Process. Synth., 2013, 2(3), 211-230

Link to article

Flow chemistry as a versatile tool for the synthesis of triazoles

Otvos, S. B.; Fulop, F.; Catal. Sci. Technol., 2015, 5(11), 4926-4941

Link to article

Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation

Mandity, I.; Fulop, F.; Nekka, I.; Bogdan, D.; Gati, T.; Beni, S.; Juhasz, T.; Palko, M.; Paragi, G.; Toth, G.; Chem. Commun., 2019, 55, 3061-3064

Link to article

Flow chemistry for designing sustainable chemical synthesis

Flow Chemistry in Space – A Unique Opportunity to Perform Extraterrestrial Research

Flow chemistry in the multi-step synthesis of natural products

Flow chemistry: Intelligent processing of gas-liquid transformations using a tube-in-tube reactor

Brzozowski, M.; O'Brien, M.; Ley, S. V.; Polyzos, A.; Acc. Chem. Res., 2015, 48(2), 349-362

Link to article

Flow chemistry syntheses of natural products

Pastre, J. C.; Browne, D. L.; Ley, S. V.; Chem. Soc. Rev., 2013, 42, 8849-8869

Link to article

Flow chemistry: Towards a more sustainable heterocyclic synthesis

Flow chemistry vs. flow analysis

Trojanowicz, M.; Talanta, 2016, 146, 621-640

Link to article

Flow fine synthesis with heterogeneous catalysts

Masuda, K.; Ichitsuka T.; Koumura, N.; Sato, K.; Kobayashi, S.; Tetrahedron, 2018, 74(15), 1705-1730

Link to article

Flow Hydrogenation of 1,3,5-Trinitrobenzenes over Cu-Based Catalysts as an Efficient Approach for the Preparation of Phloroglucinol Derivatives

Flow hydrogenation of p-nitrophenol with nano-Ag/Al2O3

Paun, C.; Slowik, G.; Lewin, E.; Sa, J.; RSC Adv., 2016, 6, 87564-87568

Link to article

Flow-oriented synthetic design in the continuous preparation of the aryl piperazine drug flibanserin

Bana, P.; Szigetvari, A.; Koti, J.; Eles, J.; Greiner, I.; React. Chem. Eng., 2019, 4, 652-657

Link to article

Flow photochemistry — from microreactors to large-scale processing

Flow reactors for drug discovery flow for reaction optimization, library synthesis, and scale up

Jones, R. V.; Csajagi, Cs.; Szekelyhidi, Zs.; Kovacs, I.; Borcsek, B.; Urge, L.; Darvas, F.; Chemistry Today, 2008, 26(3), 10-13

Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe

Plutschack, M. B.; McQuade, D. T.; Valenti, G.; Seeberger, P. H.; Beilstein J. Org. Chem., 2013, 9, 2022-2027

Link to article

Flow synthesis of annulated 5-aryl-substituted pyridines by tandem intramolecular inverse-electron-demand hetero-/retro-Diels–Alder reaction

Martin, R. E.; Lenz, M.; Alzieu, T.; Aebi, J. D.; Forzy, L.; Tetrahedron Letters, 2013, 54(49), 6703-6707

Link to article

Flow Synthesis of Biologically-Relevant Compound Libraries

Formation of benzocyclobutenes from substituted oxocycloocta-2,8-diene-1,2-dicarboxylates

Bezensek, J.; Groselj, U.; Pockaj, M.; Svete, J.; Stanovnik, B.; Tetrahedron Letters, 2015, 56(42), 5705-5708

Link to article

Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors

Saluste, G.; Albarran, M. I.; Alvarez, R. M.; Rabal, O.; Ortega, M. A.; Blanco, C.; Kurz, G.; Salgado, A.; Pevarello, P.; Bischoff, J. R.; Pastor, J.; Oyarzabal, J.; PLoS One, 2012, 7(10), e45964

Link to article

From the Lindlar catalyst to supported ligand‐modified palladium nanoparticles: selectivity patterns and accessibility constraints in the continuous‐flow three‐phase hydrogenation of acetylenic compounds

Vile, G.; Almora-Barrios, N.; Mitchell, S.; Lopez, N.; Perez-Ramirez, J.; Chem. Eur. J., 2014, 20, 5926-5937

Link to article

Fully automated sequence-specific synthesis of α-peptides using flow chemistry

Knudsen, K. R.; Ladlow, M.; Bandpey, Z.; Ley, S. V.; J. Flow Chem., 2014, 4(1), 18-21

Link to article

Functional Group Interconversion Reactions in Continuous Flow Reactors

Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation

Brice, H.; Clayden, J.; Hamilton, S. D.; Beilstein J. Org. Chem., 2010, 6(22)

Link to article

General methods for the synthesis and late-stage diversification of 2,4-substituted 7-azaindoles

Varnes, J. G.; McGuire, T.; Meadows, R. E.; Barlaam, B.; Clark, J.; Cook, C. R.; Davison, G.; Dishington, A.; De Savi, C.; Donald, C.; Grebe, T.; Hande, S.; Hawkins, J.; Hird, A. W.; Holmes, J.; Lister, A.; Lucas, S.; Moore, J.; Moore, E.; Patel, A.; Pike, K. G.; Roberts, B.; Stark, A.; Stead, D.; Thakur, K.; Turner, P.; Vasbinder, M.; Yang, B.; Tetrahedron Letters, 2016, 57, 4718-4722

Link to article

Gram scale de novo synthesis of 2,4-diacetamido-2,4,6-trideoxy-d-galactose

Schmolzer, C.; Nowikow, C.; Kahlig, H.; Schmid, W.; Carbohydrate Research, 2013, 367, 1-4

Link to article

Green and scalable procedure for extremely fast ligandless Suzuki-Miyaura cross-coupling reactions in aqueous IPA using solid-supported Pd in continuous flow

Mateos, C.; Rincon, J. A.; Martin-Hidalgo, B.; Villanueva, J.; Tetrahedron Letters, 2014, 55(27), 3701-3705

Link to article

Green chemistry articles of interest to the pharmaceutical industry

Andrews, I.; Dunn, P.; Hayler, J.; Himkley, B.; Hughes, D.; Kaptein, B.; Lorenz, K.; Methew, S.; Rammeloo, T.; Wang, L.; Wells, A.; White, T. D.; Org. Process Res. Dev., 2011, 15, 748-756

Link to article

Green Process Design for Reductive Hydroformylation of Renewable Olefin Cuts for Drop-In Diesel Fuels

Harnessing the versatility of continuous-flow processes: selective and efficient reactions

Mandity, I. M.; Otvos, S. B.; Szolosi, G.; Fulop, F.; Chem. Rec., 2016, 16, 1018-1033

Link to article

Hazards associated with laboratory scale hydrogenations

Chandra, T.; Zebrowski; J. P.; Journal of Chemical Health and Safety, 2016, 23(4), 16-25

Link to article

Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons

Belema, M.; Nguyen, V. N.; Romine, J. L.; St. Laurent, D. R.; Lopez, O. D.; Goodrich, J. T.; Nower, P. T.; O'Boyle, D. R.; Lemm, J. A.; Fridell, R. A.; Gao, M.; Fang, H.; Krause, R. G.; Wang, Y.; Oliver, A. J.; Good, A. C.; Knipe, J. O.; Meanwell, N. A.; Snyder, L. B.; J. Med. Chem., 2014, 57, 1995-2012

Link to article

Heterogeneous catalysis in continuous flow microreactors: a review of methods and applications

Tanimu, A.; Jaenicke, S.; Alhooshani, K.; Chem. Eng. J., 2017, 327, 792-821

Link to article

Heterogeneous Catalysis to Drive the Waste-to-Pharma Concept: From Furanics to Active Pharmaceutical Ingredients

Heterogeneous catalytic hydrogenation reactions in continuous-flow reactors

Irfan, M.; Glasnov, N. T.; Kappe, O. C.; ChemSusChem, 2011, 12(3), 300-316

Link to article

Heterogeneous catalytic synthesis using microreactor technology

Frost, C. G.; Mutton, L.; Green Chem., 2010, 12, 1687-1703

Link to article

Heterogeneous enantioselective hydrogenation in a continuous-flow fixed-bed reactor system: Hydrogenation of activated ketones and their binary mixtures on Pt–alumina–cinchona alkaloid catalysts

Szollosi, G.; Makra, Zs.; Fekete, M.; Fulop, F.; Bartok, M.; Catal. Lett., 2012, 142(7), 889-894

Link to article

Heterogeneous hydrogenation reactions using a continuous flow high pressure device

Desai, B.; Kappe, C. O.; J. Comb. Chem., 2005, 7(5), 641-643

Link to article

Heterogeneous Palladium Catalysts in the Hydrogenation of the Carbon-carbon Double Bond

Heterogeneous versus homogeneous palladium catalysts for ligandless Mizoroki-Heck reactions: A comparison of batch/microwave and continuous‐flow processing

Glasnov, T. N.; Findenig, S.; Kappe, C. O.; Chem. Eur. J., 2009, 15, 1001-1010

Link to article

High-efficiency aminocarbonylation by introducing CO to a pressurized continuous flow reactor

Csajagi, Cs.; Borcsek, B.; Niesz, K.; Kovacs, I.; Szekelyhidi, Zs.; Bajko, Z.; Ugre, L.; Darvas, F.; Org. Lett., 2008, 10(8), 1589-1592

Link to article

High pressure in organic chemistry on the way to miniaturization

Benito-Lopez, F.; Egberink, E. J. M.; Reinhoudt, D. N.; Verboom, W.; Tetrahedron, 2008, 64(43), 10023-10040

Link to article

High-speed microwave assisted synthesis of SEA0400 – a selective inhibitor of the Na+/Ca2+ exchanger

de la Cruz, G. G.; Groschner, K.; Kappe, C. O.; Glasnov; T. N.; Tetrahedron Letters, 2012, 53, 3731-3734

Link to article

High-temperature Boc deprotection in flow and its application in multistep reaction sequences

Bogdan, R. A.; Charaschanya, M.; Dombrowski, A. W.; Wang, Y.; Djuric, S. W.; Org. Lett., 2016, 18(8), 1732-1735

Link to article

High-throughput Screening of Vanadium (IV) Oxide via Continuous Hydrothermal Flow Synthesis Reactor

Highly active catalytic Ru/TiO₂ nanomaterials for continuous production of γ-valerolactone

Highly efficient 1,4-addition of aldehydes to nitroolefins

Otvos, S. B.; Mandity, I. M.; Fulop, F.; ChemSusChem, 2012, 5, 266-269

Link to article

Highly efficient iron(0) nanoparticle-catalyzed hydrogenation in water in flow

Hudson, R.; Hamasaka, G.; Osako, T.; Yamada, Y. M. A.; Li, C-J.; Uozumi, Y.; Moores, A.; Green Chem., 2013, 15, 2141-2148

Link to article

Highly efficient reversible addition-fragmentation chain‐transfer polymerization in ethanol/water via flow chemistry

Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives

Lengyel, L.; Nagy, T. Zs.; Sipos, G.; Jones, R.; Dorman, Gy.; Urge, L.; Darvas, F.; Tetrahedron Letters, 2012, 53(7), 738-743

Link to article

Highly selective continuous-flow synthesis of potentially bioactive deuterated chalcone derivatives

Hsieh, C.; Otvos, S. B.; Wu, Y.; Mandity, I. M.; Chang, F.; Fulop, F.; ChemPlusChem, 2015, 80(5), 859-864

Link to article

Highly selective deuteration of pharmaceutically relevant nitrogen-containing heterocycles: a flow chemistry approach

Otvos, S. B.; Mandity, I. M.; Fulop, F.; Mol. Divers., 2011, 15, 605-611

Link to article

Highly selective hydrogenation of R‑(+)-limonene to (+)-p- 1‑menthene in batch and continuous flow reactors

Rubulotta, G.; Luska, K. L.; Urbina-Blanco, C. A.; Eifert, T.; Palkovits, R.; Quadrelli, E. A.; Thieuleux, C.; Leitner, W.; ACS Sustainable Chem. Eng., 2017, 5, 3762-3767

Link to article

Hit optimization of 5-substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) inhibitors with in vivo activity in model of mood disorders

Furlotti, G.; Alisi, M. A.; Cazzolla, N.; Dragone, P.; Durando, L.; Magaro, G.; Mancini, F.; Mangano, G.; Ombrato, R.; Vitiello, M.; Armirotti, A.; Capurro, V.; Lanfranco, M.; Ottonello, G.; Summa, M.; Reggiani, A.; J. Med. Chem., 2015, 58(22), 8920-8937

Link to article

HKUST-1 silica aerogel composites: novel materials for the separation of saturated and unsaturated hydrocarbons by conventional liquid chromatography

Nuzhdin, A. L.; Shalygin, A. S.; Artiukha, E. A.; Chibiryaev, A. M.; Bukhtiyarova, G. A.; Martyanov, O. N.; RSC Adv., 2016, 6, 62501-62507

Link to article

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

Manzoni, L.; Belvisi, L.; Bianchi, A.; Conti, A.; Drago, C.; de Matteo, M.; Ferrante, L.; Mastrangelo, E.; Perego, P.; Potenza, D.; Scolastico, C.; Servida, F.; Timpano, G.; Vasile, F., Rizzo, V.; Seneci, P.; Bioorg. Med. Chem., 2012, 20, 6687-6708

Link to article

How the mode of Candida antarctica lipase B immobilization affects the continuous-flow kinetic resolution of racemic amines at various temperatures

Boros, Z.; Falus, P.; Markus, M.; Weiser, D.; Olah, M.; Hornyanszky, G.; Nagy, J.; Poppe, L.; Journal of Molecular Catalysis B: Enzymatic, 2013, 85-86, 119-125

Link to article

Hydrogenation of Aqueous Acetic Acid over Ru-Sn/TiO2 Catalyst in a Flow-Type Reactor, Governed by Reverse Reaction

Hydrogenation of Dinitrobenzenes to Corresponding Diamines Over Cu–Al Oxide Catalyst in a Flow Reactor

Hydrogenation of nitroarenes to anilines in a flow reactor using polystyrene supported rhodium in a catalyst-cartridge (Cart-Rh@PS)

Sharma, S.; Yamini; Das, P.; New J. Chem., 2018, 43, 1764-1769

Link to article

Hydrothermal formose reaction

Kopetzki, D.; Antonietti, M.; New J. Chem., 2011, 35, 1787-1794

Link to article

Hyperbranched PDMAEMA-functionalized SiO₂ microparticles: ATRP polymerization and grafting in a continuous flow reactor

Identification and Characterization of Carprofen as a Multitarget Fatty Acid Amide Hydrolase/Cyclooxygenase Inhibitor

Favia, A. D.; Habrant, D.; Scarpelli, R.; Migliore, M.; Albani, C.; Bertozzi, S. M.; Dionisi, M.; Tarozzo, G.; Piomelli, D.; Cavalli, A.; De Vivo, M.; J. Med. Chem., 2012, 55, 8807-8826

Link to article

Identification and validation of small molecule modulators of the NusB-NusE interaction

Identification of a novel orally bioavailable phosphodiesterase 10A inhibitor with efficacy in animal models of schizophrenia

Bartolome-Nebreda, J. M.; de Diego, S. A. A.; Artola, M.; Delgado, F.; Delgado, O.; Martin-Martin, M. L.; Martinez-Viturro, C. M.; Pena, M. A.; Tong, H. M.; Van Gool, M.; Alonso, J. M.; Fontana, A.; Macdonald, G. J.; Megens, A.; Langlois, X.; Somers, M.; Vanhoof, G.; Conde-Ceide, S.; J. Med. Chem., 2015, 58(2), 978-993

Link to article

Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington’s Disease

Immobilized iron oxide nanoparticles as stable and reusable catalysts for hydrazine‐mediated nitro reductions in continuous flow

Moghaddam, M. M.; Pieber, B.; Glasnov, T.; Kappe, C. O.; ChemSusChem, 2014, 7(11), 3122-3131

Link to article

Immobilized phosphine–phosphite rhodium complexes: highly active and enantioselective catalysts for asymmetric hydrogenation under continuous flow conditions

Immobilized transition metals as catalysts for cross-couplings in continuous flow — A critical assessment of the reaction mechanism and metal leaching

Important industrial procedures revisited in flow: very efficient oxidation and N-alkylation reactions with high atom-economy

Sipos, G.; Gyollai, V.; Dorman, G.; Kocsis, L.; Jones, R. V.; Darvas, F.; Journal of Flow Chemistry, 2013, 3(2), 51-58

Link to article

Improved and scalable synthesis of building blocks for the modular synthesis of teraryl-based alpha-helix mimetics

Trobe, M.; Breinbauer, R.; Monatsh. Chem., 2016, 147(3), 509-521

Link to article

Improved continuous flow processing: benzimidazole ring formation via catalytic hydrogenation of an aromatic nitro compound

Chen, J.; Przyuski, K.; Roemmele, R.; Bakale, R. P.; Org. Process Res. Dev., 2014, 18(11), 1427-1433

Link to article

Improving productivity of multiphase flow aerobic oxidation using a tube-in-tube membrane contactor

Burkholder, M.; Gilliland, S. E.; Luxon, A.; Tang, C.; Gupton, B. F.; Catalysts, 2019, 9(1), 95

Link to article

Improving the sustainability and safety of ursodeoxycholic acid synthesis in continuous flow process with water

In situ sulfidation of Pd/C: A Straightforward method for chemoselective conjugate reduction by continuous hydrogenation

Moore, J. C.; Howie, R. A.; Bourne, S. L.; Jenkins, G. N.; Licence, P.; Poliakoff, M.; George, M. W.; ACS Sustainable Chem. Eng., 2019, 7(19), 16814-16819

Link to article

In vitro reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors

Tan, G-Y.; Zhu, F.; Deng, Z.; Liu, T.; Synthetic and Systems Biotechnology, 2016, 1, 25-33

Link to article

Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites

Shamovsky, I.; de Graaf, C.; Alderin, L.; Bengtsson, M.; Bladh, H.; Börjesson, L.; Connolly, S.; Dyke, H. J.; van den Heuvel, M.; Johansson, H.; Josefsson, B.; Kristoffersson, A.; Linnanen, T.; Lisius, A.; Mannikko, R.; Norden, B.; Price, S.; Ripa, L.; Rognan, D.; Rosendahl, A.; Skrinjar, M.; Urbahns, K.; J. Med. Chem., 2009, 52, 7706-7723

Link to article

Innovative benign-by-design flow chemistry protocols: from bio(nano)materials synthesis to biomass/waste valorisation

Wang, B.; Balu, A. M.; Xuan, J.; Gonzalez-Arellano, C.; Bai, Z.; Luque, R.; Chemistry Today, 2016, 34(6), 58-63

Link to article

Insights into the activity, selectivity and stability of heterogeneous catalysts in the continuous flow hydroconversion of furfural

Garcia-Olmo, A. J.; Yepez, A.; Balu, A. M.; Romero, A. A.; Li, Y.; Luque, R.; Catal. Sci. Technol., 2016, 6(13), 4705-4711

Link to article

Insights into the selective hydrogenation of levulinic acid to γ-valerolactone using supported mono- and bimetallic catalysts

Al-Naji, M.; Yepez, A.; Balu, A. M.; Romero, A. A.; Chen, Z.; Wilde, N.; Li, H.; Shih, K.; Glaser, R.; Luque, R.; Journal of Molecular Catalysis A: Chemical, 2016, 417, 145-152

Link to article

Integrated Suzuki Cross-Coupling/Reduction Cascade Reaction of meta-/para-Chloroacetophenones and Arylboronic Acids under Batch and Continuous Flow Conditions

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Ingham, R. J.; Battilocchio, C.; Hawkins, J. M.; Ley, S. V.; Beilstein J. Org. Chem., 2014, 10, 641-652

Link to article

Intensified Continuous Flow Michaelis-Arbuzov Rearrangement toward Alkyl Phosphonates

Interesting applications on a novel high pressure high temperature microfluidic-based flow reactor

Niesz, K.; Csajagi, Cs.; Borcsek, B.; Jones, R. V.; Darvas, F.; Nanotechnology, 2007, 4, 426-429

Link to article

Intramolecular aglycon delivery enables the synthesis of 6-deoxy-β-d-manno-heptosides as fragments of Burkholderia pseudomallei and Burkholderia mallei capsular polysaccharide

Kenfack, M. T.; Bleriot, Y.; Gauthier, C.; J. Org. Chem., 2014, 79(10), 4615-4634

Link to article

Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism

Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs)

Investigation, optimization and synthesis of sulfamoyloxy-linked aminoacyl-AMP analogues

Redwan, I. N.; Ljungdahl, T.; Grotli, M.; Tetrahedron, 2012, 68(5), 1507-1514

Link to article

Ion exchange resins: Catalyst recovery and recycle

Barbaro, P.; Liguori, F.; Chem. Rev., 2009, 109(2), 515-529

Link to article

Iridium(I)-catalyzed ortho-directed hydrogen isotope exchange in continuous-flow reactors

Habraken, E.; Haspeslagh, P.; Vliegen, M.; Noel, T.; J. Flow Chem., 2015, 5(1), 2-5

Link to article

Iridium(I)-NHC-phosphine complex-catalyzed hydrogen generation and storage in aqueous formate/bicarbonate solutions using a flow reactor – Effective response to changes in hydrogen demand

Horvath, H.; Papp, G.; Kovacs, H.; Katho, A.; Joo, F.; Int. J. Hydrogen Energy, 2019, 44(53), 28527-28532

Link to article

Isolation and characterization of anti-adenoviral secondary metabolites from marine actinobacteria

Strand, M.; Carlsson, M.; Uvell, H.; Islam, K.; Edlund, K.; Cullman, I.; Altermark, B.; Mei, Y-F.; Elofsson, M.; Willassen, N. P.; Wadell, G.; Almqvist, F. Mar. Drugs, 2014, 12(2), 799-821

Link to article

Landscape and opportunities for active pharmaceutical ingredient manufacturing in developing African economies

Panayides, J. L.; Riley, D. L.; Chikwamba, R.; Strydom, I.; React. Chem. Eng., 2019, 4, 457-489

Link to article

Latest highlights in liquid-phase reactions for organic synthesis in microreactors

Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound

Tarleton, M.; Gilbert, J; Robertson, J. M.; McCluskey, A.; Sakoff, A. J; MedChemComm, 2011, 2, 31-37

Link to article

Library synthesis of cardiomyogenesis inducing compounds using an efficient two-step-one-flow process

Schon, M.; Dreier, D.; Schnurch, M.; Mihovilovic, M. D.; Monatsh. Chem., 2016, 147(3), 523-532

Link to article

Life cycle analysis within pharmaceutical process optimization and intensification: case study of active pharmaceutical ingredient production

Ott, D.; Kralisch, D.; Dencic, I.; Hessel, V.; Laribi, Y.; Perrichon, P. D.; Berguerand, C.; Kiwi-Minsker, L.; Loeb, P.; ChemSusChem, 2014, 7, 3521-3533

Link to article

Ligand ordering determines the catalytic response of hybrid palladium nanoparticles in hydrogenation

Albani, D.; Vile, G.; Mitchell, S.; Witte, P. T.; Almora-Barrios, N.; Verel, R.; Lopez, N.; Perez-Ramirez, J.; Catal. Sci. Technol., 2016, 6(6), 1621-1631

Link to article

Lipase-catalyzed kinetic resolution of 2-methylene-substituted cycloalkanols in batch and continuous-flow modes

Tomin, A.; Hornyanszky, G.; Kupai, K.; Dorko, Zs.; Urge, L.; Darvas, F.; Poppe, L.; Process Biochemistry, 2010, 45(6), 859-865

Link to article

Lipase-catalyzed monostearin synthesis under continuous flow conditions

Junior, I. I.; Flores, M. C.; Sutili, F. K.; Leite, S. G. F.; Miranda, L. S. de M.; Leal, I. C. R.; de Souza, R. O. M. A.; Org. Process Res. Dev., 2012, 16(5), 1098-1101

Link to article

Liquid phase oxidation chemistry in continuous-flow microreactors

Gemoets, H. P. L.; Su, Y.; Shang, M.; Hessel V.; Luque, R.; Noel, T.; Chem. Soc. Rev., 2016, 45, 83-117

Link to article

Living with our machines: Towards a more sustainable future

Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions

Measurement of supramolecular effective molarities for intramolecular H-bonds in zinc porphyrin-imidazole complexes

Jinks, M. A.; Sun, H.; Hunter, C. A.; Org. Biomol. Chem., 2014, 12, 1440-1447

Link to article

Mechanistic insights into copper(I)‐catalyzed azide‐alkyne cycloadditions using continuous flow conditions

Fuchs, M.; Goessler, W.; Pilger, C.; Kappe, C. O.; Adv. Synth. Catal., 2010, 352, 323-328

Link to article

Mechanochemical Synthesis of Nickel-Modified Metal-Organic Frameworks for Reduction Reactions

Merging single-atom-dispersed silver and carbon nitride to a joint electronic system via copolymerization with silver tricyanomethanide

Chen, Z.; Pronkin, S.; Fellinger, T. P.; Kailasam, K.; Vile, G.; Albani, D.; Krumeich, F.; Leary, R.; Barnard, J.; Thomas, J. M.; Perez-Ramirez, J.; Antonietti, M.; Dontsova, D.; ACS Nano, 2016, 10(3), 3166-3175

Link to article

Mesoscale flow chemistry: A plug-flow approach to reaction optimisation

Wheeler, R. C.; Benali, O.; Deal, M.; Farrant, E.; MacDonald, S. J. F.; Warrington, B. H.; Org. Process Res. Dev., 2007, 11, 704-710

Link to article

Metal-catalyzed amidation

Roy, S.; Roy, S.; Gribble, G. W.; Tetrahedron, 2012, 68, 9867-9923

Link to article

Metathesis reactions on solid-phase: Towards new synthesis challenges

Franzen, R. G.; Top Catal., 2016, 59, 1143-1150

Link to article

Methods for the synthesis of indole-3-carboxylic acid esters

Methylation using dimethylcarbonate catalysed by ionic liquids under continuous flow conditions

Glasnov, T. N.; Holbrey, J. D.; Kappe, C. O.; Seddon, K. R.; Yan, T.; Green Chem., 2012, 14, 3071-3076

Link to article

Micro reactors, flow reactors and continuous flow synthesis

Watts, P.; Wiles, C.; Journal of Chemical Research, 2012, 36, 181-193

Link to article

Micro-total process system machine (μ-TPSM) for rapid synthesis of antiretroviral darunavir

Microfluidic asymmetrical synthesis and chiral analysis

Microfluidics in commercial applications; an industry perspective

Haber, C.; Lab Chip, 2006, 6, 1118-1121

Link to article

Microreactors for peptide synthesis: looking through the eyes of twenty first century !!!

Ramesh, S.; Cherkupally, P.; de la Torre, B. G.; Govender, T.; Kruger, H. G.; Albericio, F.; Amino Acids, 2014, 46, 2091-2104

Link to article

Microwave-assisted and continuous flow multistep synthesis of 4-(pyrazol-1-yl)carboxanilides

Obermayer, D.; Glasnov, T. N.; Kappe, C. O.; J. Org. Chem., 2011, 76(16), 6657-6669

Link to article

Microwave-assisted grafting to MCM-41 silica and its application as catalyst in flow chemistry

Oliverio, M.; Procopio, A.; Glasnov, T. N.; Goessler, W.; Kappe, C. O.; Aust. J. Chem., 2011, 64, 1522-1529

Link to article

Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters

Desai, B.; Dallinger, D.; Kappe, C. O.; Tetrahedron, 2006, 62, 4651-4664

Link to article

Microwave-assisted synthesis of medium-sized heterocycles

Sharma, A.; Appukkuttan, P.; Van der Eycken, E.; Chem. Commun., 2012, 48, 1623-1637

Link to article

Microwave chemistry enabling the synthesis of biologically relevant amines

Spencer, J.; Future Med. Chem., 2010, 2(2), 161-168

Link to article

Microwave heating and conventionally-heated continuous-flow processing as tools for performing cleaner palladium-catalyzed decarboxylative couplings using oxygen as the oxidant – a proof of principle study

Rudzinski, D. M.; Leadbeater, N. E.; Green Processing and Synthesis, 2013, 2(4), 323-328

Link to article

Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library

Spencer, J.; Patel, H.; Amin, J.; Callear, S. K.; Coles, S. J.; Deadman, J. J.; Furman, C.; Mansouri, R.; Chavatte, P.; Millet, R.; Tetrahedron Letters, 2012, 53, 1656-1659

Link to article

Mild and selective hydrogenation of nitro compounds using palladium nanoparticles supported on amino‐functionalized mesocellular foam

Verho, O.; Gustafson, K. P. J.; Nagendiran, A.; Tai, C.; Backvall, J.; ChemCatChem, 2014, 6(11), 3153-3159

Link to article

Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507

Scott, D. A.; Dakin, L. A.; Daly, K.; Del Valle, D. J.; Diebold, R. B.; Drew, L.; Ezhuthachan, J.; Gero, T. W.; Ogoe, C. A.; Omer, C. A.; Redmond, S. P.; Repik, G.; Thakur, K.; Ye, Q.; Zheng, X.; Bioorg. Med. Chem. Lett., 2013, 23, 4591-4596

Link to article

Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB)

Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN)

Modeling, synthesis and biological evaluation of potential retinoid X receptor‐selective agonists: Novel halogenated analogues of 4‐[1‐(3,5,5,8,8‐pentamethyl‐5,6,7,8‐tetrahydro‐2‐naphthyl)ethynyl]benzoic acid (Bexarotene)

Furmick, J. K.; Kaneko, I.; Walsh, A. N.; Yang, J.; Bhogal, J. S.; Gray, G. M.; Baso, J. C.; Browder, D. O., Prentice, J. L. S.; Montano, L. A.; Huynh, C. C.; Marcus, L. M.; Tsosie, D. G.; Kwon, J. S.; Quezada, A.; Reyes, N. M.; Lemming, B.; Saini, P.; van der Vaart, A.; Groy, T. L.; Marshall, P. A.; Jurutka, P. W.; Wagner, C. E.; ChemMedChem, 2012, 7, 1551-1566

Link to article

Molecularly imprinted hydrogels as functional active packaging materials

Benito-Pena, E.; Gonzalez-Vallejo, V.; Rico-Yuste, A.; Barbosa-Pereira, L.; Cruz, J. M.; Bilbao, A.; Alvarez-Lorenzo, C.; Moreno-Bondi, M. C.; Food Chemistry, 2016, 190, 487-494

Link to article

Molecularly imprinted polymers for cleanup and selective extraction of curcuminoids in medicinal herbal extracts

Wulandari, M.; Urraca, J. L.; Descalzo, A. B.; Amran, M. B.; Moreno-Bondi, M. C.; Analytical and Bioanalytical Chemistry, 2015, 407(3), 803-812

Link to article

Monitoring glycan-protein interactions by NMR spectroscopic analysis: A simple chemical tag that mimics natural CH–π interactions

Calle, L. P.; Echeverria, B.; Franconetti, A.; Serna, S.; Fernandez-Alonso, M. C.; Diercks, T.; Canada, F. J.; Arda, A.; Reichardt, N. C.; Jimenez-Barbero, J.; Chem. Eur. J., 2015, 21(32), 11408-11416

Link to article

Multi-step continuous-flow synthesis

Multi-step solvent-free 3 m2 footprint pilot miniplant for the synthesis of annual half ton rufinamide precursor

Multigram-scale flow synthesis of the chiral key intermediate of (−)-paroxetine enabled by solvent-free heterogeneous organocatalysis

Multigram Synthesis of Tetrasubstituted Dihydrobenzofuran GSK973 Enabled by High-Throughput Experimentation and a Claisen Rearrangement in Flow

Multistep continuous‐flow synthesis in medicinal chemistry: Discovery and preliminary structure-activity relationships of CCR8 ligands

Petersen, T. P.; Mirsharghi, S.; Rummel, P. C.; Thiele, S.; Rosenkilde, M. M.; Ritzen, A.; Ulven, T.; Chem. Eur. J., 2013, 19(28), 9343-9350

Link to article

Multistep continuous-flow synthesis of condensed benzothiazoles

Lovei, K.; Greiner, I.; Eles, J.; Szigetvari, A.; Dekany, M.; Levai, S.; Novak, Z.; Turos, I. Gy.; J. Flow Chem., 2015, 5(2), 74-81

Link to article

Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties as novel synthetic polyphenols directed against HIV-1

Flores, A.; Camarasa, M. J.; Perez-Perez, M. J.; San-Felix, A.; Balzarini, J.; Quesada, E.; Org. Biomol. Chem., 2014, 12, 5278-5294

Link to article

My twenty years in microwave chemistry: from kitchen ovens to microwaves that aren’t microwaves

Kappe, C. O.; Chem. Rec., 2019, 19(1), 15-39

Link to article

N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist

Boldron, C.; Besse, A.; Bordes, M.; Tissandie, S.; Yvon, X.; Gau, B.; Badorc, A.; Rousseaux, T.; Barre, G.; Meneyrol, J.; Zech, G.; Nazare, M.; Fossey, V.; Pflieger, A.; Bonnet-Lignon, S.; Millet, L.; Briot, C.; Dol, F.; Herault, J.; Savi, P.; Lassalle, G.; Delesque, N.; Herbert, J.; Bono, F.; J. Med. Chem., 2014, 57(17), 7293-7316

Link to article

Nafion‐H‐catalyzed high‐temperature/high‐pressure synthesis of a triarylmethane in continuous‐flow mode

Nanocatalysis in continuous flow: supported iron oxide nanoparticles for the heterogeneous aerobic oxidation of benzyl alcohol

Obermayer, D.; Balu, A. M.; Romero, A. A.; Goessler, W.; Luque, R.; Kappe, C. O.; Green Chem., 2013, 15, 1530-1537

Link to article

Nanocatalysis in flow

Ricciardi, R.; Huskens, J.; Verboom, W.; ChemSusChem, 2015, 8(16), 2586-2605

Link to article

Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow

Nagendiran, A.; Sorensen, H.; Johansson, M. J.; Tai, C-W.; Backvall, J-E.; Green Chem., 2016, 18(9), 2632-2637

Link to article

Nanoparticle synthesis completed with in situ catalyst preparation performed on a high-pressure high-temperature continuous flow reactor

Niesz, K.; Hornyak, I.; Borcsek, B.; Darvas, F.; Microfluidics and Nanofluidics, 2008, 5(3), 411-416

Link to article

Nanoscale Pd supported on 3D porous carbon for enhanced selective oxidation of benzyl alcohol

Nanotechnology tools in pharmaceutical R&D

Kumar, C. S. S. R.; Materials Today, 2010, 12, 24-30

Link to article

Natural‐product‐like spiroketals and fused bicyclic acetals as potential therapeutic agents for B‐cell chronic lymphocytic leukaemia

Milroy, L-G.; Zinzalla, G.; Loiseau, F.; Qian, Z.; Prencipe, G.; Pepper, C.; Fegan, C.; Ley, S. V.; ChemMedChem, 2008, 3, 1922-1935

Link to article

Natural product synthesis on the fly – multistep continuous reaction shows the power of automated flow synthesis

Ritter, S. K.; Chemical & Engineering News, 2006, 84(10), 17

Link to article

New copper-containing catalysts based on modified amorphous silica and their use in flow azide—alkyne cycloaddition

Burilov, V. A.; Nurmukhametova, A. N.; Belov, R. N.; Mironova, D. A.; Vorob'ev, V. V.; Osin, Yu. N.; Antipin, I. S.; Russian Chemical Bulletin Int. Ed., 2018, 67, 461-468

Link to article

New data in the enantioselective hydrogenation of ethyl pyruvate on Pt-cinchona chiral catalyst using continuous-flow fixed-bed reactor system: The origin of rate enhancement

Szollosi, Gy.; Cserenyi, Sz.; Balazsik, K.; Fulop, F.; Bartok, M.; Journal of Molecular Catalysis A: Chemical, 2009, 305, 155-160

Link to article

New data on the Orito reaction: Effect of substrate structure on nonlinear phenomenon

Balazsik, K.; Cserenyi, S.; Szollosi, G.; Fulop, F.; Bartok, M.; Catal. Lett., 2008, 125, 401-407

Link to article

New data to the origin of rate enhancement on the Pt-cinchona catalyzed enantioselective hydrogenation of activated ketones

Szollosi, G.; Cserenyi, S.; Fulop, F.; Bartok, M.; Journal of Catalysis, 2008, 260(2), 245-253

Link to article

New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics

Pilkington-Miksa, M.; Araldi, E. M.; Arosio, D.; Belvisi, L.; Civera, M.; Manzoni, L.; Org. Biomol. Chem., 2016, 14(12), 3221-3233.

Link to article

Nickel-catalyzed reductive [2+2] cycloaddition of alkynes

Nitro lignin-derived nitrogen-doped carbon as an efficient and sustainable electrocatalyst for oxygen reduction

Graglia, M.; Pampel, J.; Hantke, T.; Fellinger, T. P.; Esposito D.; ACS Nano, 2016, 10(4), 4364-4371

Link to article

Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis

Jarrad, A. M.; Debnath, A.; Miyamoto, Y.; Hansford, K. A.; Pelington, R.; Butler, M. S.; Bains, T.; Karoli, T.; Blaskovich, M. A. T.; Eckmann, L.; Cooper, M. A.; Eur. J. Med. Chem., 2016, 120, 353-362

Link to article

Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

Gauthier, C.; Chassagne, P.; Theillet, F. X.; Guerreiro, C.; Thouron, F.; Nato, F.; Delepierre, M.; Sansonetti, P. J.; Phalipon, A.; Mulard, L. A.; Org. Biomol. Chem., 2014, 12, 4218-4232

Link to article

Novel biorefinery concept via Achmatowicz rearrangement, synthesis of pentane‐1,2,5‐triol from furfuryl alcohol

Simeonov, S. P.; Ravutsov, M. A.; Mihovilovic, M. D.; ChemSusChem, 2019, 12(12), 2748-2754

Link to article

Novel derivatives of usnic acid effectively inhibiting reproduction of influenza A virus

Shtro, A. A.; Zarubaev, V. V.; Luzina, O. A.; Sokolov, D. N.; Kiselev, O. I.; Salakhutdinov, N. F.; Bioorg. Med. Chem., 2014, 22(24), 6826-6836

Link to article

Novel evidence on the role of the nucleophilic intermediate complex in the Orito-reaction: Unexpected inversion in the enantioselective hydrogenation of 2,2,2-trifluoroacetophenone on Pt-cinchona chiral catalyst using continuous-flow fixed-bed reactor

Szollosi, G.; Cserenyi, S.; Bartok, M.; Catal. Lett., 2010, 134, 264-269

Link to article

Novel phosphine-phosphites and their use in asymmetric hydrogenation

Farkas, G.; Balogh, S.; Szollosy, A.; Urge, L.; Darvas, F.; Bakos, J.; Tetrahedron: Asymmetry, 2011, 22(24), 2104-2109

Link to article

Novel process windows for enabling, accelerating and uplifting flow chemistry

Hessel, V.; Kralisch, D.; Kockmann, N.; Noel, T.; Wang, Q.; ChemSusChem, 2013, 6(5), 746-789

Link to article

Novel spirotetracyclic zwitterionic dual H1/5-HT2A receptor antagonists for the treatment of sleep disorders

Gianotti, M.; Botta, M.; Brough, S.; Carletti, R.; Castiglioni, E.; Corti, C.; Dal-Cin, M.; Fratte, S. D.; Korajec, D.; Lovric, M.; Merlo, G.; Mesic, M.; Pavone, F.; Piccoli, L.; Rast, S.; Roscic, M.; Sava, A.; Smehil, M.; Stasi, L.; Togninelli, A.; Wigglesworth, M. J.; J. Med. Chem., 2010, 53, 7778-7795

Link to article

Nucleophilic aromatic substitution of heterocycles using a high-temperature and high-pressure flow reactor

Charaschanya, M.; Bogdan, A. R.; Wang, Y.; Djuric, S. W.; Tetrahedron Letters, 2016, 57(9), 1035-1039

Link to article

Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1

Manka, J. T.; Rodriguez, A. L.; Morrison, R. D.; Venable, D. F.; Cho, H. P.; Blobaum, A. L.; Daniels, J. S.; Niswender, C. M.; Conn, P. J.; Lindsley, C. W.; Emmitte, K. A.; Bioorg. Med. Chem. Lett., 2013, 23(18), 5091-5096

Link to article

On the regioselectivity of the Gould–Jacobs reaction: Gas-phase versus solution-phase thermolysis

One-For-All Polyolefin Functionalization: Active Ester as Gateway to Combine Insertion Polymerization with ROP, NMP, and RAFT

One-pot multi-step synthesis of gamma-valerolactone from furfuryl alcohol: Microwave vs continuous flow reaction studies

One-pot reductive amination of aldehydes with nitroarenes over an Au/Al2O3 catalyst in a continuous flow reactor

Artiukha, E. A.; Nuzhdin, A. L.; Bukhtiyarova, G. A.; Zaytsev, S. Yu.; Plyusnin, P. E.; Shubinbc, Yu. V.; Bukhtiyarov, V. I.; Cat. Sci. Technol., 2015, 5(10), 4741-4745

Link to article

One-pot synthesis of secondary amines from nitroarenes and aldehydes on supported copper catalysts in a flow reactor: The effect of the support

Online monitoring and analysis for autonomous continuous flow self-optimizing reactor systems

Fabry, D. C.; Sugiono, E.; Rueping M.; React. Chem. Eng., 2016, 1, 129-133

Link to article

Optically pure, structural, and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach

Liu, M.; Mountford, S. J.; Richardson, R. R.; Groenen, M.; Holliday, N. D.; Thompson, P. E.; J. Med. Chem., 2016, 59(13), 6059-6069

Link to article

Optimisation of conditions for O‐benzyl and N‐benzyloxycarbonyl protecting group removal using an automated flow hydrogenator

Knudsen, K. R.; Holden, J.; Ley, S. V.; Ladlow, M.; Adv. Synth. Catal., 2007, 349, 535-538

Link to article

Optimization of novel indazoles as highly potent and selective inhibitors of phosphoinositide 3-kinase δ for the treatment of respiratory disease

Down, K.; Amour, A.; Baldwin, I. R.; Cooper, A. W. J.; Deakin, A. M.; Felton, L. M.; Guntrip, S. B.; Hardy, C.; Harrison, Z. A.; Jones, K. L.; Jones, P.; Keeling, S. E.; Le, J.; Livia, S.; Lucas, F.; Lunniss, C. J.; Parr, N. J.; Robinson, E.; Rowland, P.; Smith, S.; Thomas, D. A.; Vitulli, G.; Washio, Y.; Hamblin, J. N.; J. Med. Chem., 2015, 58(18), 7381-7399

Link to article

Optimized Conditions for Passerini-Smiles Reactions and Applications to Benzoxazinone Syntheses

Organic synthesis: March of the machines

Ley, S. V.; Fitzpatrick, D. E.; Ingham, R. J.; Myers, R. M.; Angewandte Chemie Int. Ed., 2015, 54(11), 3449-3464

Link to article

Origin of problems related to Staudinger reduction in carbopeptoid syntheses

Csordas, B.; Nagy, A.; Harmat, V.; Zsoldos-Mady, V.; Leveles, I.; Pinter, I.; Farkas, V.; Perczel, A.; Amino Acids, 2016, 48(11), 2619-2633

Link to article

Origin of the rate enhancement and enantiodifferentiation in the heterogeneous enantioselective hydrogenation of 2,2,2-trifluoroacetophenone over Pt/alumina studied in continuous-flow fixed-bed reactor system

Szollosi, Gy.; Cserenyi, Sz.; Bucsi, I.; Bartok, T.; Fulop, F.; Bartok, M.; Applied Catalysis A: General, 2010, 382, 263-271

Link to article

Out-smarting smart drug modafinil through flow chemistry

Oxazolomycins: Natural product lead structures for novel antibacterials by click fragment conjugation

Bagwell, C. L.; Moloney, M. G.; Yaqoob, M.; Bioorg. Med. Chem. Lett., 2010, 20(7), 2090-2094

Link to article

p-Nitrophenol flow hydrogenation with nano-Cu2O grafted on polymeric resin

Paun, C.; Gizinski, D.; Zienkiewicz-Machnik, M.; Banas, D.; Kubala-Kukus, A.; Sa, J.; Catalysis Communications, 2017, 92, 61-64

Link to article

Palladium on carbon-catalyzed Suzuki-Miyaura coupling reaction using an efficient and continuous flow system

Hattori, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Catalysts, 2015, 5, 18-25

Link to article

Papain‐specific activating esters in aqueous dipeptide synthesis

de Beer, R. J. A. C.; Zarzycka, B.; Mariman, M.; Amatdjais-Groenen, H. I. V.; Mulders, M. J.; Quaedflieg, P. J. L. M.; van Delft, F. L.; Nabuurs, S. B.; Rutjes, F. P. J. T.; ChemBioChem, 2012, 13(9), 1319-1326

Link to article

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor

Parallel synthesis of 1,2,4-triazole derivatives using microwave and continuous-flow techniques

Szommer T.; Lukacs A.; Kovacs J.; Szabo, M. J.; Hoffmann M. G.; Schmitt M. H.; Gerencser J.; Mol. Divers., 2012, 16(1), 81-90

Link to article

Particle-based immobilized enzymatic reactors in microfluidic chips

Pd nanoparticles on carbon layer wrapped 3D TiO₂ as efficient catalyst for selective oxidation of benzyl alcohol

Pd-P nanoalloys supported on porous carbon frame as efficient catalyst for benzyl alcohol oxidation

Photocatalytic Activity of Sulfanyl Porphyrazine/Titanium Dioxide Nanocomposites in Degradation of Organic Pollutants

Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor

Salamoun, J. M.; McQueeney, K. E.; Patil, K.; Geib, S. J.; Sharlow, E. R.; Lazo, J. S.; Wipf, P.; Org. Biomol. Chem., 2016, 14(27), 6398-6402

Link to article

Polysaccharides from Burkholderia species as targets for vaccine development, immunomodulation and chemical synthesis

Cloutier, M.; Muru, K.; Ravicoularamin, G.; Gauthier, C.; Nat. Prod. Rep., 2018, 35, 1251-1293

Link to article

Polystyrene Resins: Versatile and Economical Support for Heterogeneous Nanocatalysts in Sustainable Organic Reactions

Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure–activity relationship (SAR) studies

Nuzzi, A.; Fiasella, A.; Ortega, J. A.; Pagliuca, C.; Ponzano, S.; Pizzirani, D.; Bertozzi, S. M.; Ottonello, G.; Tarozzo, G.; Reggiani, A.; Bandiera, T.; Bertozzi, F.; Piomelli, D.; Eur. J. Med. Chem., 2016, 111, 138-159

Link to article

Potentiating N-Hydroxyphthalimide Catalyzed Aerobic Aldehyde Oxidations in Continuous Flow

Practical synthesis of (S)-pyrrolidin-2-yl-1H-tetrazole, incorporating efficient protecting group removal by flow-reactor hydrogenolysis

Franckevicius, V.; Knudsen, K. R.; Ladlow, M.; Longbottom, D. A.; Ley, S. V.; Synlett, 2006, 6, 889-892

Link to article

Preclinical characterization of the FAAH inhibitor JNJ-42165279

Keith, J. M.; Jones, W. M.; Tichenor, M.; Liu, J.; Seierstad, M.; Palmer, J. A.; Webb, M.; Karbarz, M.; Scott, B. P.; Wilson, S. J.; Luo, L.; Wennerholm, M. L.; Chang, L.; Rizzolio, M.; Rynberg, R.; Chaplan, S. R.; Breitenbucher, J. G.; ACS Med. Chem. Lett., 2015, 6(12), 1204-1208

Link to article

Precursor Nuclearity and Ligand Effects in Atomically-Dispersed Heterogeneous Iron Catalysts for Alkyne Semi-Hydrogenation

Prediction of Optimal Conditions of Hydrogenation Reaction Using the Likelihood Ranking Approach

Preparation of HKUST-1@silica aerogel composite for continuous flow catalysis

Shalygin, A. S.; Nuzhdin, A. L.; Bukhtiyarova, G. A.; Martyanov, O. N.; J. Sol-Gel Sci. Technol., 2017, 84(3), 446-452

Link to article

Preparation of vinyl ethers using a Wittig approach, and their subsequent hydrogenation employing continuous-flow processing

Balti, M.; Efrit, M. L.; Leadbeater, N. E.; Tetrahedron Lett., 2016, 57, 1804-1806

Link to article

Present and future of cyclopropanations in fragrance chemistry

Schroder, F.; Chem. Biodivers., 2014, 11(11), 1734-1751

Link to article

Process development of a potent glucosylceramide synthase inhibitor

Cooper, C. G. F.; Lee, E. R.; Silva, R. A.; Bourque, A. J.; Clark, S.; Katti, S.; Nivorozkhin, V.; Org. Process Res. Dev., 2012, 16(5), 1090-1097

Link to article

Process intensification for the continuous flow hydrogenation of ethyl nicotinate

Ouchi, T.; Battilocchio, C.; Hawkins, J. M.; Ley, S. V.; Org. Process Res. Dev., 2014, 18(11), 1560-1566

Link to article

Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors

George, D. M.; Huntley, R. J.; Cusack, K.; Duignan, D. B.; Hoemann, M.; Loud, J.; Mario, R.; Melim, T.; Mullen, K.; Somal, G.; Wang, L.; Edmunds, J. J.; PlosOne, 2018, online article

Link to article

Protecting group principles suited to late stage functionalization and global deprotection in oligosaccharide synthesis

Pt-cinchonidine catalyzed asymmetric catalytic cascade reaction of 2-nitrophenylpyruvates in flow system

Kovacs, L.; Szollosi, Gy.; Fulop, F.; J. Flow Chem., 2015, 5(4), 210-215

Link to article

Pyrido[2,3-d]pyrimidin-5-ones: A novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors

Huang, H.; Hutta, D. A.; Rinker, J. M.; Hu, H.; Parsons, W. H.; Schubert, C.; DesJarlais, R. L.; Crysler, C. S.; Chaikin, M. A.; Donatelli, R. R.; Chen, Y.; Cheng, D.; Zhou, Z.; Yurkow, E.; Manthey, C. L.; Player, M. R.; J. Med. Chem., 2009, 52(4), 1081-1099

Link to article

Quinazolinones, Quinazolinthiones, and Quinazolinimines as Nitric Oxide Synthase Inhibitors: Synthetic Study and Biological Evaluation

Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines

Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform

Desai, B.; Dixon, K.; Farrant, E.; Feng, Q.; Gibson, K. R.; van Hoorn, W. P.; Mills, J.; Morgan, T.; Parry, D. M.; Ramjee, M. K.; Selway, C. N.; Tarver, G. J.; Whitlock, G.; Wright, A. G.; J. Med. Chem., 2013, 56(7), 3033-3047

Link to article

Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

Liang, S. H.; Collier, T. L.; Rotstein, B. H.; Lewis, R.; Steck, M.; Vasdev, N.; Chem. Commun., 2013, 49(78), 8755-8757

Link to article

Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry

Ekholm, F. S.; Mandity, I. M.; Fulop, F.; Leino, R.; Tetrahedron Lett., 2011, 52, 1839-1841

Link to article

Rapid synthesis of substituted pyrrolines and pyrrolidines by nucleophilic ring closure at activated oximes

Chandan, N.; Thompson, A. L.; Moloney, M. G.; Org. Biomol. Chem., 2012, 10, 7863-7868

Link to article

Reaction screening in continuous flow reactors

Mohamed, D. K. B.; Yu, X.; Li, J.; Wu, J.; Reaction screening in continuous flow reactors; Tetrahedron Lett., 2016, 57, 3965-3977.

Link to article

ReactIR flow cell: a new analytical tool for continuous flow chemical processing

Carter, C. F.; Lange, H.; Ley, S. V.; Baxendale, I. R.; Wittkamp, B.; Goode, J. G.; Gaunt, N. L.; Org. Process Res. Dev., 2010, 14, 393-404

Link to article

Reactivation of catalysts for methanol-to-hydrocarbons conversion with hydrogen

Reagent-controlled stereoselective synthesis of (±)-gallo- and (±)-epigallo-catechin gallates

Tanaka, H.; Chino, A.; Takahashi, T.; Tetrahedron Letters, 2012, 53, 2493-2495

Link to article

Rearrangement of N-alkyl 1,2-amino alcohols. Synthesis of (S)-toliprolol and (S)-propanolol

Duthion, B.; Metro, T.; Padro, D. G.; Cossy, J.; Tetrahedron, 2009, 65(33), 6696-6706

Link to article

Recent advances for serial processes of hazardous chemicals in fully integrated microfluidic systems

Singh, R.; Lee, H. J.; Singh, A. K.; Kim, D. P.; Korean Journal of Chemical Engineering, 2016, 33(8), 2253-2267

Link to article

Recent advances in asymmetric catalysis in flow

Zhao, D.; Ding, K.; ACS Catal., 2013, 3(5), 928-944

Link to article

Recent advances in micro reaction technology

Wiles, C.; Watts, P.; Chemical Communications, 2011, 47(23), 6512-6535

Link to article

Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules

Reconstruction of humins formation mechanism from decomposition products: A GC-MS study based on catalytic continuous flow depolymerizations

Recycling the waste: the development of a catalytic Wittig reaction

O'Brien, C. J.; Tellez, J. L.; Nixon, Z. S.; Kang, L. J.; Carter, A. L.; Kunkel, S. R.; Przeworski, K. C.; Chass, G. A.; Angew. Chem. Int. Ed., 2009, 48(37), 6836-6839

Link to article

Reductive amination in the synthesis of pharmaceuticals

Reductive amination by continuous-flow hydrogenation: direct and scalable synthesis of a benzylpiperazine

Liu, J.; Fitzgerald, A. E.; Mani, N. S.; Synthesis, 2012, 44(15), 2469-2473

Link to article

Reductive amination of ketones: novel one-step transfer hydrogenations in batch and continuous-flow mode

Falus, P.; Boros, Z.; Hornyanszky, G.; Nagy, J.; Darvas, F.; Urge, L.; Poppe, L.; Tetrahedron Letters, 2011, 52, 1310-1312

Link to article

Regio-, diastereo-, and enantioselective nitroso-Diels–Alder reaction of 1,3-diene-1-carbamates catalyzed by chiral phosphoric acids

Pous, J.; Courant, T.; Bernadat, G.; Iorga, B. I.; Blanchard, F.; Masson, G.; J. Am. Chem. Soc., 2015, 137(37), 11950-11953

Link to article

Regioselective catalytic alkylation of N-heterocycles in continuous flow

Sipocz, T.; Lengyel., L.; Sipos, G.; Kocsis, L.; Dorman, Gy.; Jones, R. V.; Darvas, F.; J. Flow Chem., 2016, 6(2), 117-122

Link to article

Reissert indole synthesis using continuous-flow hydrogenation

Colombo, E.; Ratel, P.; Mounier, L.; Guillier, F.; J. Flow Chem., 2011, 2, 68-73

Link to article

Research spotlight: Microwave chemistry enabling the synthesis of biologically relevant amines

Spencer, J.; Future Med. Chem, 2010, 2(2), 161-168

Link to article

Reversal of the ee in enantioselective hydrogenation of activated ketones in continuous-flow fixed-bed reactor system

Cserenyi, Sz.; Szollosi, Gy.; Szori, K.; Fulop, F.; Bartok, M.; Catalysis Communications, 2010, 12, 14-19

Link to article

Reversible and efficient inhibition of UDP‐galactopyranose mutase by electrophilic, constrained and unsaturated UDP‐galactitol analogues

Ansiaux, C.; N'Go, I.; Vincent, S. P.; Chem. Eur. J., 2012, 18(46), 14860-14866

Link to article

Revisiting the deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions

Ruthenium and osmium complexes of novel carbohydrate derived salen ligands: Synthesis, characterization and in situ ligand reduction

Mandal, S.; Mandal, S.; Seth, D. K.; Mukhopadhyay, B.; Gupta, P.; Inorganica Chimica Acta, 2013, 398, 83-88

Link to article

Safe generation and synthetic utilization of hydrazoic acid in a continuous flow reactor

Gutmann, B.; Obermayer, D.; Roduit, J. P.; Roberge, D. M.; Kappe, C. O.; J. Flow Chem., 2012, 2(1), 8-19

Link to article

Safe hydrogenation of organic compounds and their property studies

Soung, M. J.; Woo, S. J.; Shin, D. J.; APEC Youth Scientist Journal, 2015, 7(1), 45-53

Link to article

Structure-activity relationship studies of mitogen activated protein kinase interacting kinase (MNK) 1 and 2 and BCR-ABL1 inhibitors targeting chronic myeloid leukemic cells

Cherian, J.; Nacro, K.; Poh, Z. Y.; Guo, S.; Jeyaray, D. A.; Wong, Y. X.; Ho, M.; Yang, H. Y.; Joy, J. K.; Kwek, Z. P.; Liu, B.; Wee, J. L. K.; Ong, E. H.; Choong, M. L.; Poulsen, A.; Lee, M. A.; Pendharkar, V.; Ding, L. J.; Manoharan, V.; Chew, Y. S.; Sangthongpitag, K.; Lim, S.; Ong, S. T.; Hill, J.; Keller, T. H.; J. Med. Chem., 2016, 59(7), 3063-3078

Link to article

SBA materials as support of iridium catalyst for hydrogenation reactions

Kiderys, A.; Kot, M.; Janiszewska, E.; Pietrowski, M.; Yang, C-M.; Zielinski, M.; Catalysis Today, 2019, accepted manuscript

Link to article

Scalable and straightforward synthesis of all isomeric (cyclo)alkylpiperidines

Scalable continuous flow hydrogenations using Pd/Al2O3-coated rectangular cross-section 3D-printed static mixers

Scalable synthesis of an integrin-binding peptide mimetic for biomedical applications

Riches, A. G.; Cablewski, T.; Glattauer, V.; Thissen, H.; Meagher, L.; Tetrahedron, 2012, 68(46), 9448-9455

Link to article

Scale-up of flow-assisted synthesis of C2-symmetric chiral PyBox ligands

Battilocchio, C.; Baumann, M.; Baxendale, I. R.; Biava, M.; Kitching, M. O.; Ley, S. V.; Martin, R. E.; Ohnmacht, S. A.; Tappin, N. D. C.; Synthesis, 2012, 4, 635-647

Link to article

Scale-up synthesis of a deuterium-labeled cis-cyclobutane-1,3-dicarboxylic acid derivative using continuous photo flow chemistry

Yamashita, T.; Nishikawa, H.; Kawamoto, T.; Tetrahedron, 2019, 75(5), 617-623

Link to article

Scaling up and validation of hydrogenation reactions using a continuous-flow microfluidics-based reactor, H-Cube®

Spadoni, C; Jones, R. V.; Urge, L.; Darvas, F.; Chemistry Today, 2006, January/February 2006, 38-41

Scouting in silico different chemo-types of PDE4 inhibitors to guide the design of new anti-inflammatory/antioxidant agents

Scrap waste automotive converters as efficient catalysts for the continuous-flow hydrogenations of biomass derived chemicals

Selective catalytic hydrogenations in a microfluidics-based high throughput flow reactor on ion-exchange supported transition metal complexes: A modular approach to the heterogenization of soluble complex catalysts

Horvath, H. H.; Papp, G.; Csajagi, Cs.; Joo, F.; Cat. Commun., 2007, 8, 442-446

Link to article

Selective continuous flow phenylacetylene hydrogenation over Pd-biogenic calcium carbonate

Selective ensembles in supported palladium sulfide nanoparticles for alkyne semi-hydrogenation

Albani, D.; Shahrokhi, M.; Chen, Z.; Mitchell, S.; Hauert, R.; Lopez, N.; Perez-Ramirez, J.; Nature Communications, 2018, 9, article number: 2634

Link to article

Selective hydrodeoxygenation of acetophenone derivatives using a Fe25Ru75@SILP catalyst: a practical approach to the synthesis of alkyl phenols and anilines

Selective Hydrogenation of 5-Acetoxymethylfurfural over Cu-Based Catalysts in a Flow Reactor: Effect of Cu-Al Layered Double Hydroxides Synthesis Conditions on Catalytic Properties

Selective hydrogenation of furfural using TiO₂-Fe₂O₃/C from Ti-Fe-MOFs as sacrificial template: Microwave vs Continuous flow experiments

Selective liquid‐phase hydrogenation of a nitro group in substituted nitrobenzenes over Au/Al2O3 catalyst in a packed‐bed flow reactor

Nuzhdin, A. L.; Moroz, B. L.; Bukhtiyarova, G. A.; Reshetnikov, S. I.; Pyrjaev, P. A.; Aleksandrov P. V.; Bukhtiyarov, V. I.; ChemPlusChem, 2015, 80(12), 1741-1749

Link to article

Self-assembly of a helical zinc-europium complex: speciation in aqueous solution and luminescence

Deiters, E.; Eliseeva, S. V.; Bunzli, J. C. G.; Front. Chem., 2013, 1(15), 1-14

Link to article

Self-optimizing reactor systems: Algorithms, on‐line analytics, setups, and strategies for accelerating continuous flow process optimization

Sequential nitration/hydrogenation protocol for the synthesis of triaminophloroglucinol: Safe generation and use of an explosive intermediate under continuous-flow conditions

Cantillo, D.; Damm, M.; Dallinger, D.; Bauser, M.; Berger, M.; Kappe, C. O.; Org. Process Res. Dev., 2014, 18(11), 1360-1366

Link to article

SiliaCat: A versatile catalyst series for synthetic organic chemistry

Ciriminna, R.; Pandarus, V.; Fidalgo, A.; Ilharco, L. M.; Beland, F.; Pagliaro, M.; Org. Process Res. Dev., 2015, 19(7), 755-768

Link to article

Single-atom heterogeneous catalysts based on distinct carbon nitride scaffolds

Chen, Z.; Vorobyeva, E.; Mitchell, S.; Fako, E.; Lopez, N.; Collins, S. M.; Leary, R. K.; Midgley, P. A.; Hauert, R.; Perez-Ramirez, J.; National Science Review, 2018, 5(5), 642-652

Link to article

Single operation stereoselective synthesis of Aerangis lactones: Combining continuous flow hydrogenation and biocatalysts in a chemoenzymatic sequence

Fink, M. J.; Schon, M.; Rudroff, F.; Schnurch, M.; Mihovilovic, M. D.; ChemCatChem, 2013, 5, 724-727

Link to article

Site‐selective deuterated‐alkene synthesis with palladium on boron nitride

Yabe, Y.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Chem. Eur. J., 2013, 19, 484-488

Link to article

Small-Molecule Inhibitors of the NusB−NusE Protein−Protein Interaction with Antibiotic Activity

Solvent-free continuous operations using small footprint reactors: A key approach for process intensification

Ouchi, T.; Mutton, R. J.; Rojas, V.; Fitzpatrick, D. E.; Cork, D. G.; Battilocchio, C.; Ley, S. V.; ACS Sustainable Chem. Eng., 2016, 4, 1912-1916

Link to article

Solvent-free enzymatic process for biolubricant production in continuous microfluidic reactor

Madarasz, J.; Nemeth, D.; Bakos, J.; Gubicza, L.; Bakonyi, P.; Journal of Cleaner Production, 2015, 93, 140-144

Link to article

Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control

Voltrova, S.; Srogl, J.; Org. Chem. Front., 2014, 1, 1067-1071

Link to article

Spirocyclic dihydropyridines by electrophile-induced dearomatizing cyclization of N-alkenyl pyridinecarboxamides

Senczyszyn, J.; Brice, H.; Clayden, J.; Org. Lett., 2013, 15(8), 1922-1925

Link to article

Stepwise aromatic nucleophilic substitution in continuous flow. Synthesis of an unsymmetrically substituted 3,5-diamino-benzonitrile library

Lengyel, L.; Gyollai, V.; Nagy, T.; Dorman, G.; Terleczky, P.; Hada, V.; Nogradi, K.; Sebok, F.; Urge, L.; Darvas, F.; Mol. Divers., 2011, 15(3), 631-638

Link to article

Stereo‐ and chemoselective character of supported CeO2 catalysts for continuous‐flow three‐phase alkyne hydrogenation

Vile, G.; Wrabetz, S.; Floryan, L.; Schuster, M. E.; Girgsdies, F.; Teschner, D.; Perez-Ramirez, J.; ChemCatChem, 2014, 6(7), 1928-1934

Link to article

Stereocontrolled synthesis of the cis‐hydroxydecalin system: Towards biologically active 19‐nor‐clerodanes

Mirzayans, P. M.; Pouwer, R. H.; Williams, C. M.; Bernhardt, P. V.; Eur. J. Org. Chem., 2012, 2012(8), 1633-1638

Link to article

Stereoselective approaches to 2,3,6-trisubstituted piperidines. An enantiospecific synthesis of quinolizidine (−)-217A

Mancey, N. C.; Sandon, N.; Auvinet, A. L.; Butlin, R. J.; Czechtizky, W.; Harrity, J. P. A.; Chem. Commun., 2011, 47(35), 9804-9806

Link to article

Stereoselective catalytic synthesis of active pharmaceutical ingredients in homemade 3D‐printed mesoreactors

Rossi, S.; Porta, R.; Brenna, D.; Puglisi, A.; Benaglia, M.; Angew. Chem. Int. Ed., 2017, 56(15), 4290-4294

Link to article

Stereoselective metal‐free reduction of chiral imines in batch and flow mode: a convenient strategy for the synthesis of chiral active pharmaceutical ingredients

Brenna, D.; Benaglia, M.; Porta, R.; Fernandes, S.; Burke, A. J.; Eur. J. Org. Chem., 2017, 2017(1), 39-44

Link to article

Stereoselective reduction of prochiral cyclic 1,3-diketones using different biocatalysts

Stereoselective syntheses and transformations of chiral 1,3-aminoalcohols and 1,3-diols derived from nopinone

Szakonyi, Zs.; Gonda, T.; Otvos, S. B.; Fulop, F.; Tetrahedron: Asymmetry, 2014, 25, 1138-1145

Link to article

Stereoselective total synthesis of the marine macrolide sanctolide A

Yadav, J. S.; Suresh, B.; Srihari, P.; Eur. J. Org. Chem., 2015, 2015(26), 5856-5863

Link to article

Straightforward hetero Diels-Alder reactions of nitroso dienophiles by microreactor technology

Monbaliu, J-C. M. R.; Cukalovic, A.; Marchand-Brynaert, J.; Stevens, C. V.; Tetrahedron Letters, 2010, 51, 5830-5833

Link to article

Structural assessment of novel spiro-naphthalene-1.2′- [1,3,4]oxadiazol-4-ones prepared under batch and flow chemistry with a concise antifungal and anti(myco)bacterial activity

Structural Effects of Metal Single-Atom Catalysts for Enhanced Photocatalytic Degradation of Gemfibrozil

Structural identification of petroleum acids by conversion to hydrocarbons and multidimensional gas chromatography-mass spectrometry

Wilde, M. J.; Rowland S. J.; Analytical Chemistry, 2015, 87(16), 8457-8465

Link to article

Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives

Bazin, H. G.; Li, Y.; Khalaf, J. K.; Mwakwari, S.; Livesay, M. T.; Evans, J. T.; Johnson, D. A.; Bioorg. Med. Chem. Lett., 2015, 25(6), 1318-1323

Link to article

Structural studies of the O-acetyl-containing O-antigen from a Shigella flexneri serotype 6 strain and synthesis of oligosaccharide fragments thereof

Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening

Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents

Ng, P. S.; Manjunatha, U. H.; Rao, S. P. S.; Camacho, L. R.; Ma, N. L.; Herve, M.; Noble, C. G.; Goh, A.; Peukert, S.; Diagana, T. T.; Smith, P. W.; Kondreddi, R. R.; Eur. J. Med. Chem., 2015, 106, 144-156

Link to article

Structure and reactivity of supported hybrid platinum nanoparticles for the flow hydrogenation of functionalized nitroaromatics

Vile, G.; Almora-Barrios, N.; Lopez, N.; Perez-Ramirez, J.; ACS Catal., 2015, 5(6), 3767-3778

Link to article

Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase

Nichols, D. A.; Jaishankar, P.; Larson, W.; Smith, E.; Liu, G.; Beyrouthy, R.; Bonnet, R.; Renslo, A. R.; Chen, Y.; J. Med. Chem., 2012, 55(5), 2163-2172

Link to article

Structure-based optimization of naphthyridones into potent ATAD2 bromodomain inhibitors

Bamborough, P.; Chung, C.; Furze, R. C.; Grandi, P.; Michon, A.; Sheppard, R. J.; Barnett, H.; Diallo, H.; Dixon, D. P.; Douault, C.; Jones, E. J.; Karamshi, B.; Mitchell, D. J.; Prinjha, R. K.; Rau, C.; Watson, R. J.; Werner, T.; Demont, E. H.; J. Med. Chem., 2015, 58(15), 6151-6178

Link to article

Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential

Coteron, J. M.; Marco, M.; Esquivias, J.; Deng, X.; White, K. L; White, J.; Koltun, M.; Mazouni, F. E.; Kokkonda, S.; Katneni, K.; Bhamidipati, R.; Shackleford, D. M.; Angulo-Barturen, I.; Ferrer, S. B.; Jimenez-Diaz, M. B.; Gamo, F. J.; Goldasmith, E. J.; Charman, W. N.; Bathurst, I.; Floyd, D.; Matthews, D.; Burrows, J. N.; Rathod, P. K.; Charman, S. A.; Philips, M. A; J. Med. Chem., 2011, 54(15), 5540-5561

Link to article

Structuring hybrid palladium nanoparticles in metallic monolithic reactors for continuous-flow three-phase alkyne hydrogenation

Albani, D.; Vile, G.; Toro, M. A. B.; Kaufmann, R.; Mitchell, S.; Perez-Ramirez, J.; React. Chem. Eng., 2016, 1, 454-462

Link to article

Studies of long chain lipids in insects by high temperature gas chromatography and high temperature gas chromatography–mass spectrometry

Sutton, P. A.; Wilde, M. J.; Martin, S. J.; Cvacka, J.; Vrkoslav, V.; Rowland, S. J.; Journal of Chromatography A, 2013, 1297, 236-240

Link to article

Studies on the continuous-flow synthesis of nonpeptidal bis-tetrahydrofuran moiety of Darunavir

Leao, R. A. C.; Lopes, R. de O.; de M. Bezerra, M. A.; Muniz, M. N.; Casanova, B. B.; Gnoatto, S. C. B.; Gosmann, G.; Kocsis, L.; de Souza, R. O. M. A.; de M. Miranda, L. S.; Journal of Flow Chemistry, 2015, 5(4), 216-219

Link to article

Studies on the synthesis of the lasubine alkaloids

Aslam, N. F. M.; Simon, O.; Bates, R. W.; Tetrahedron, 2018, 74(38), 5032-5039

Link to article

Substrate engineering: Effects of different N-protecting groups in the CAL-B-catalysed asymmetric O-acylation of 1-hydroxymethyl-tetrahydro-β-carbolines

Megyesi, R.; Forro, E.; Fulop, F.; Tetrahedron, 2018, 74(21), 2634-2640

Link to article

Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer’s Disease

Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4

Synergistic interaction within bifunctional ruthenium nanoparticle/SILP catalysts for the selective hydrodeoxygenation of phenols

Luska, K. L.; Migowski, P.; El Sayed, S.; Leitner, W.; Angew. Chem., 2015, 127(52), 15976-15981

Link to article

Syntheses of 4-, 5-, 6-, and 7-substituted tryptamine derivatives and the use of a bromine atom as a protecting group

Rene, O.; Fauber, B. P.; Tetrahedron Letters, 2014, 55(4), 830-833

Link to article

Syntheses of four enantiomers of 2,3-diendo- and 3-endo-aminobicyclo[2.2.2]oct-5-ene-2-exo-carboxylic acid and their saturated analogues

Palko, M.; Hanninen, M. M.; Sillanpaa, R.; Fulop, F.; Molecules, 2013, 18(12), 15080-15093

Link to article

Synthesis and activity of putative small-molecule inhibitors of the F-Box protein SKP2

Synthesis and anticancer activity of a series of norcantharidin analogues

Tarleton, M.; Gilbert, J.; Sakoff, J. A.; McCluskey, A.; Eur. J. Med. Chem., 2012, 54, 573-581

Link to article

Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease

Alexandre, F-R.; Brandt, G.; Caillet, C.; Chaves, D.; Convard, T.; Derock, M.; Gloux, D.; Griffon, Y.; Lallos, L.; Leroy, F.; Liuzzi, M.; Loi, A-G.; Moulat, L.; Musiu, C.; Parsy, C.; Rahali, H.; Roques, V.; Seifer, M.; Standring, D.; Surleraux, D.; Bioorg. Med. Chem. Lett., 2015, 25(18), 3984-3991

Link to article

Synthesis and arylation of unprotected sulfonimidamides

Maldonado; M. F.; Sehgelmeble, F.; Bjarnemark, F.; Svensson, M.; Ahman, F.; Arvidsson, P. I.; Tetrahedron, 2012, 68, 7456-7462

Link to article

Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins

McCarthy, A. R.; Pirrie, L.; Hollick, J. J.; Ronseaux, S.; Campbell, J.; Higgins, M.; Staples, O. D.; Tran, F.; Slawin, A. M. Z.; Lain, S.; Westwood, N. J.; Bioorg. Med. Chem., 2012, 20, 1779-1793

Link to article

Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

Spencer, J.; Rathnam, R. P.; Harvey, A. L.; Clements, C. J.; Clark, R. L.; Barrett, M. P.; Wong, P. E.; Male, L.; Coles, S. J.; Mackay, S. P.; Bioorg. Med. Chem., 2011, 19, 1802-1815

Link to article

Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents

Marhadour, S.; Marchand, P.; Pagniez, F.; Bazin, M. A.; Picot, C.; Lozach, O.; Ruchaud, S.; Antoine, M.; Meijer, L.; Rachidi, N.; Le Pape, P.; Eur. J. Med. Chem., 2012, 58, 543-556

Link to article

Synthesis and biological evaluation of an orally active glycosylated endomorphin-1

Varamini, P.; Mansfeld, F. M.; Blanchfield, J. T.; Wyse, B. D.; Smith, M. T.; Toth, I.; J. Med. Chem., 2012, 55(12), 5859-5867

Link to article

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting αvβ3/αvβ5 integrins and IAP proteins

Mingozzi, M.; Manzoni, L.; Arosio, D.; Dal Corso, A.; Manzotti, M.; Innamorati, F.; Pignataro, L.; Lecis, D.; Delia, D.; Seneci, P.; Gennari, C.; Org. Biomol. Chem., 2014, 12, 3288-3302

Link to article

Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists

Batie, S.; Lee, J. H.; Jama, R. A:; Browder, D. O.; Montano, L. A.; Huynh, C. C.; Marcus, L. M.; Tsosie, D. G.; Mohammed, Z.; Trang, V.; Marshall, P. A.; Jurutka, P. W.; Wagner, C. E.; Bioorg. Med. Chem., 2013, 21, 693-702

Link to article

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Lawrence, H. R.; Kazi, A.; Luo, Y.; Kendig, R.; Ge, Y.; Jain, S.; Daniel, K.; Santiago, D.; Guida, W. C.; Sebti, S. M.; Bioorg. Med. Chem., 2010, 18(15), 5576-5592

Link to article

Synthesis and biological evaluation of second-generation tropanol-based androgen receptor modulators

Sunden, H.; Holland, M. C.; Poutiainen, P. K.; Jaaskelainen, T.; Pulkkinen, J. T.; Palvimo, J. J.; Olsson, R.; J. Med. Chem., 2015, 58, 1569-1574

Link to article

Synthesis and Characterization of Late Transition Metal Complexes of Mono-Acetate Pendant Armed Ethylene Cross-Bridged Tetraazamacrocycles with Promise as Oxidation Catalysts for Dye Bleaching

Synthesis and cytotoxicity of octahydroepoxyisoindole-7-carboxylic acids and norcantharidin-amide hybrids as norcantharidin analogues

Hizartzidis, L.; Gilbert, J.; Gordon, C. P.; Sakoff, J. A.; McCluskey, A.; ChemMedChem, 2019, 14(12), 1152-1161

Link to article

Synthesis and photophysical characterization of 1- and 4-(purinyl)triazoles

Redwan, I. N.; Bliman, D.; Tokugawa, M.; Lawson, C.; Grotli, M.; Tetrahedron, 2013, 69(42), 8857-8864

Link to article

Synthesis and reactivity of 3-amino-1H-pyrazolo[4,3-c]pyridin-4(5H)-ones: development of a novel kinase-focussed library

Smyth, L. A.; Matthews, T. P.; Horton, P. N.; Hursthouse, M. B.; Collins, I.; Tetrahedron, 2010, 66, 2843-2854

Link to article

Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries

Spencer, J.; Patel, H.; Callear, S. K.; Coles, S. J.; Deadman, J. J.; Tetrahedron Letters, 2011, 52, 5905-5909

Link to article

Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase

Synthesis and structure–activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase

Luci, D. K.; Jameson, J. B.; Yasgar, A.; Diaz, G.; Joshi, N.; Kantz, A.; Markham, K., Perry, S.; Kuhn, N.; Yeung, J., Kerns, E. H.; Schultz, L.; Holinstat, M.; Nadler, J. L.; Taylor-Fishwick, D. A.; Jadhav, A.; Simeonov, A.; Holman, T. R.; Maloney, D. J.; J. Med. Chem., 2014, 57(2), 495-506

Link to article

Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer

Synthesis and structure–activity relationships of N‐(4‐benzamidino)‐oxazolidinones–potent and selective inhibitors of kallikrein‐related peptidase 6

Synthesis and structure–activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors

Ponzano, S.; Bertozzi, F.; Mengatto, L.; Dionisi, M.; Armirotti, A.; Romeo, E.; Berteotti, A.; Fiorelli, C.; Tarozzo, G.; Reggiani, A.; Duranti, A.; Tarzia, G.; Mor, M.; Cavalli, A.; Piomelli, D.; Bandiera, T.; J. Med. Chem., 2013, 56(17), 6917-6934

Link to article

Synthesis, anti‐tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones

Leese, M. P.; Jourdan, F. L.; Major, M. R.; Dohle, W.; Thomas, M. P.; Hamel, E.; Ferrandis, E.; Mahon, M. F.; Newman, S. P.; Purohit, A.; Potter, B. V. L.; ChemMedChem, 2014, 9, 798-812

Link to article

Synthesis, antitubulin, and antiproliferative SAR of C3/C1‐substituted tetrahydroisoquinolines

Dohle, W.; Leese, M. P.; Jourdan, F. L.; Major, M. R.; Bai, R.; Hamel, E.; Ferrandis, E.; Kasprzyk, P. G.; Fiore, A.; Newman, S. P.; Purohit, A.; Potter, B. V. L.; ChemMedChem, 2014, 9, 350-370

Link to article

Synthesis, biological evaluation, and molecular modeling of new 3‑(cyclopentyloxy)-4-methoxybenzaldehyde O‑(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) related phosphodiesterase 4D (PDE4D) inhibitors

Brullo, C.; Massa, M.; Rocca, M; Rotolo, C.; Guariento, S.; Rivera, D.; Ricciarelli, R.; Fedele, E.; Fossa, P.; Bruno, O.; J. Med. Chem., 2014, 57(16), 7061-7072

Link to article

Synthesis, biological evaluation, and utility of fluorescent ligands targeting the μ-opioid receptor

Schembri, L. S.; Stoddart, L. A.; Briddon, S. J.; Kellam, B.; Canals, M.; Graham, B.; Scammells, P. J.; J. Med. Chem., 2015, 58(24), 9754-9767

Link to article

Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging

Andres, J. I.; Alcazar, J.; Cid, J. M.; De Angelis, M., Iturrino, L.; Langlois, X.; Lavreysen, H.; Trabanco, A. A.; Celen, S.; Bormans, G.; J. Med. Chem., 2012, 55, 8685-8699

Link to article

Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging

Andres, J-I.; De Angelis, M.; Alcazar, J.; Iturrino, L.; Langlois, X.; Dedeurwaerdere, S.; Lenaerts, I.; Vanhoof, G.; Celen, S.; Bormans, G.; J. Med. Chem., 2011, 54, 5820-5835

Link to article

Synthesis of 12β-Methyl-18-nor-bile Acids

Synthesis of 2,6-Dimethyltyrosine-Like Amino Acids through Pinacolinamide-Enabled C-H Dimethylation of 4-Dibenzylamino Phenylalanine

Synthesis of 3-arylated 3,4-dihydrocoumarins: Combining continuous flow hydrogenation with laccase-catalysed oxidation

Suljic, S.; Pietruszka, J.; Adv. Synth. Catal., 2014, 356(5), 1007-1020

Link to article

Synthesis of 3-nitropyrrolidines via dipolar cycloaddition reactions using a modular flow reactor

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Synlett, 2010, 5, 749-752

Link to article

Synthesis of 3‐Hydroxypipecolic Acids

Synthesis of 4-fluoromethylsydnones and their participation in alkyne cycloaddition reactions

Foster, R. S.; Adams, H.; Jakobi, H.; Harrity, J. P. A.; J. Org. Chem., 2013, 78(8), 4049-4064

Link to article

Synthesis of 5‐bromomethylfurfural from cellulose as a potential intermediate for biofuel

Kumari, N.; Olesen, J. K.; Pedersen, C. M.; Bols, M.; Eur. J. Org. Chem., 2011, 2011(7), 1266-1270

Link to article

Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state

Baltus, C. B.; Press, N. J.; Antonijevic, M. D.; Tizzard, G. J.; Coles, S. J.; Spencer, J.; Tetrahedron, 2012, 68(45), 9272-9277

Link to article

Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods

Baumann, M.; Baxendale, I. R.; Kuratli, C.; Ley, S. V.; Martin, R. E.; Schneider, J.; ACS Comb. Sci., 2011, 13(4), 405-413

Link to article

Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states

Dayde, B.; Benzaria, S.; Pierra, C.; Gosselin, G.; Surleraux, D.; Volle, J.; Pirat, J.; Virieux, D.; Org. Biomol. Chem, 2012, 10, 3448-3454

Link to article

Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate

Howard, P. W.; Chen, Z.; Gregson, S. J.; Masterson, L. A.; Tiberghien, A. C.; Cooper, N.; Fang, M.; Coffils, M. J.; Klee, S.; Hartley, J. A.; Thurston, D. E.; Bioorg. Med. Chem. Lett. 2009, 19(22), 6463-6466

Link to article

Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki–Miyaura cross-couplings

Spencer, J.; Baltus, C. B.; Press, N. J.; Harrington, R. W.; Clegg, W.; Tetrahedron Letters, 2011, 52(31), 3963-3968

Link to article

Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope

Simerska, P.; Lu, H.; Toth, I.; Bioorg. Med. Chem. Lett., 2009, 19(3), 821-824

Link to article

Synthesis of a tetrasaccharide related to the triterpenoid saponin Bellisoside isolated from Bellis perennis (compositae)

Mandal, S.; Sharma, N.; Mukhopadhyay, B.; Tetrahedron: Asymmetry, 2010, 21, 2172-2176

Link to article

Synthesis of amines from alcohols in a nonepimerizing one-pot sequence – Synthesis of bioactive compounds: Cinacalcet and dexoxadrol

Guerin, C.; Bellosta, V.; Guillamot, G.; Cossy, J.; Eur. J. Org. Chem., 2012, 15, 2990-3000

Link to article

Synthesis of an azabicyclic framework towards (±)-actinophyllic acid

Mortimer, D.; Whiting, M.; Harrity, J. P. A.; Jones, S.; Coldham, I.; Tetrahedron Letters, 2014, 55, 1255-1257

Link to article

Synthesis of an undecasaccharide featuring an oligomannosidic heptasaccharide and a bacterial Kdo-lipid A backbone for eliciting neutralizing antibodies to mammalian oligomannose on the HIV-1 envelope spike

Trattnig, N.; Blaukopf, M.; Bruxelle, J-F.; Pantophlet, R.; Kosma, P.; JACS, 2019, 141(19), 7946-7954

Link to article

Synthesis of aromatic 13C/2H-α-ketoacid precursors to be used in selective phenylalanine and tyrosine protein labelling

Lichtenecker, R. J.; Org. Biomol. Chem., 2014, 12, 7551-7560

Link to article

Synthesis of benzannulated spiroketals using an oxidative radical cyclization

Sperry, J.; Liu, Y-C.; Wilson, Z. E.; Hubert, J. G.; Brimble, M. A.; Synthesis, 2011, 9, 1383-1398

Link to article

Synthesis of bioderived cinnolines and their flow-based conversion into 1,4-dihydrocinnoline derivatives

Synthesis of bivalent lactosides based on terephthalamide, N,N-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins

Leyden, R.; Velasco-Torrijos, T.; Andre, S.; Gouin, S.; Gabius, H-J.; Murphy, P. V.; J. Org. Chem., 2009, 74(23), 9010-9026

Link to article

Synthesis of Chalcones Derivatives and Their Biological Activities: A Review

Synthesis of condensed heterocycles by the Gould-Jacobs reaction in a novel three-mode pyrolysis reactor

Lengyel, L. C.; Sipos, G.; Sipocz, T.; Vago, T.; Dorman, G.; Gerencser, J.; Makara, G.; Darvas, F.; Org. Process Res. Dev., 2015, 19(3), 399-409

Link to article

Synthesis of cross‐linked glycopeptides and ureas by a mechanochemical, solvent‐free reaction and determination of their structural properties by TEM and X‐ray crystallography

Kumar, V.; Giri, S. K.; Venugopalan, P.; Kartha, K. P. R.; ChemPlusChem, 2014, 79(11), 1605-1613

Link to article

Synthesis of four (4″-, 2″-, 2′-, and 6-) monodeoxy analogs of the trisaccharide α-d-Glcp-(1→3)-α-d-Manp-(1→2)-α-d-ManpOMe recognized by Calreticulin/Calnexin

Glinschert, A.; Oscarson, S.; Carbohydrate Research, 2015, 414, 65-71

Link to article

Synthesis of functionalized 3-hydroxypiperidines

Wijdeven, M. A.; van Delft, F. L.; Rutjes, F. P. J. T.; Tetrahedron, 2010, 66, 5623-5636

Link to article

Synthesis of Fused Pyrimidinone and Quinolone Derivatives in an Automated High Temperature and High Pressure Flow Reactor

Synthesis of Highly Functionalized 4-Aminoquinolines

Synthesis of highly substituted nitropyrrolidines, nitropyrrolizines and nitropyrroles via multicomponent-multistep sequences within a flow reactor

Baumann, M.; Baxendale, I. R.; Kirschning, A.; Ley, S. V.; Wegner, J.; Heterocycles, 2011, 82(2), 1297-1316

Link to article

Synthesis of hydroxylated pyrrolidines by allenic cyclisation

Synthesis of α-substituted vinylsulfonium salts and their application as annulation reagents in the formation of epoxide- and cyclopropane-fused heterocycles

Matlock, J. V.; Fritz, S. P.; Harrison, S. A.; Coe, D. M.; McGarrigle, E. M.; Aggarwal, V. K.; J. Org. Chem., 2014, 79, 10226-10239

Link to article

Synthesis of L-[5-¹¹C]Leucine and L-α-[5-¹¹C]Methylleucine via Pd⁰-mediated ¹¹C-Methylation and Microfluidic Hydrogenation: Potentiality of Leucine PET Probes for Tumor Imaging

Synthesis of laminarin fragments and evaluation of a β-(1,3) glucan hexasaccaride-CRM197 conjugate as vaccine candidate against Candida albicans

Adamo, R.; Tontini, M.; Brogioni, G.; Romano, M. R.; Contantini, G.; Danieli, E.; Proietti, D.; Berti, F.; Constantino, P.; Journal of Carbohydrate Chemistry, 2011, 30, 249-280

Link to article

Synthesis of macrolide-saccharide hybrids by ring-closing metathesis of precursors derived from glycitols and benzoic acids

Matos, M-C.; Murphy, P. V.; J. Org. Chem., 2007, 72, 1803-1806

Link to article

Synthesis of Mepivacaine and Its Analogues by a Continuous-Flow Tandem Hydrogenation/Reductive Amination Strategy

Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors

Tite, T.; Tomas, L.; Docsa, T.; Gergely, P.; Kovensky, J.; Gueyrard, D.; Wadouachi, A.; Tetrahedron Letters, 2012, 53, 959-961

Link to article

Synthesis of N-hydroxypyrazin-2(1H)-ones via selective O-debenzylation of 1-benzyloxypyrazin-2(1H)-ones using flow methodology

Mai, A. H.; De Borggraeve, W. M.; J. Flow Chem., 2015, 5(1), 6-10

Link to article

Synthesis of N-propynyl analogues of peptide nucleic acid (PNA) monomers and their use in the click reaction to prepare N-functionalized PNAs

Howarth, N. M.; Ricci, J.; Tetrahedron, 2011, 67, 9588-9594

Link to article

Synthesis of natural and unnatural cyclooligomeric depsipeptides enabled by flow chemistry

Lucke, D.; Dalton, T.; Ley, S. V.; Wilson Z. E.; Chem. Eur. J., 2016, 22(12), 4206-4217

Link to article

Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds

Joyard, Y.; Azzouz, R.; Bischoff, L.; Papamicael, C.; Labar, D.; Bol, A.; Bol, V.; Vera, P.; Gregoire, V.; Levacher, V.; Bohn, P.; Bioorg. Med. Chem., 2013, 21, 3680-3688

Link to article

Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity

Borcard, F.; Baud, M.; Bello, C.; Dal Bello, G.; Grossi, F.; Pronzato, P.; Cea, M.; Nencioni, A.; Vogel, P.; Bioorg. Med. Chem. Lett., 2010, 20(17), 5353-5356

Link to article

Synthesis of Novel Camphor-Derived Bifunctional Thiourea Organocatalysts

Ricko, S.; Golobic, A.; Svete, J.; Stanovnik, B.; Groselj, U.; Chirality, 2015, 27(1), 39-52

Link to article

Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups and their evaluation as antimicrobial agents

Workman, D. G.; Hunter, M.; Dover, L. G.; Tetard, D.; Journal of Inorganic Biochemistry, 2016, 160, 49-58

Link to article

Synthesis of oxaspiropiperidines as a strategy for lowering logD

Synthesis of phenols via fluoride-free oxidation of arylsilanes and arylmethoxysilanes

Rayment, E. J.; Summerhill, N.; Anderson, E. A.; J. Org. Chem., 2012, 77(16), 7052-7060

Link to article

Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations

Baumann, M.; Baxendale, I. R.; Hornung, C. H.; Ley, S. V.; Rojo, M. V; Roper, K. A.; Molecules, 2014, 19(7), 9736-9759

Link to article

Synthesis of spirocyclic thiazolidinediones using ring-closing metathesis and one-pot sequential ring-closing/cross metathesis

Dhara, K.; Paladhi, S.; Midya, G. C.; Dash, J.; Org. Biomol. Chem., 2011, 9, 3801-3807

Link to article

Synthesis of Staphylococcus aureus type 5 capsular polysaccharide repeating unit using novel L-FucNAc and D-FucNAc synthons and immunochemical evaluation

Danieli, E.; Proietti, D.; Brogioni, G.; Romano, M. R.; Cappelletti, E.; Tontini, M.; Berti, F.; Lay, L.; Costantino, P.; Adamo, R.; Bioorg. Med. Chem., 2012, 20, 6403-6415

Link to article

Synthesis of sugar-lactams from azides of glucuronic acid

Loukou, C.; Tosin, M.; Muller-Bunz, H.; Murphy, P. V.; Carbohydrate Research, 2007, 342(12-13), 1953-1959

Link to article

Synthesis of symmetric dinitro‐functionalised Tröger’s base analogues

Bhuiyan, M. D. H.; Mahon, A. B.; Jensen, P.; Clegg, J. K.; Try, A. C.; Eur. J. Org. Chem., 2009, 5, 687-698

Link to article

Synthesis of 2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane (TAIW) from 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazaisowurtzitane (TADBIW) by catalytic hydrogenolysis using a continuous flow process

Dong, K.; Sun, C. H.; Song, J. W., Wei, G. X.; Pang, S. P.; Org. Process Res. Dev., 2014, 18, 1321-1325

Link to article

Synthesis of tetrazole analogues of amino acids using Fmoc chemistry: isolation of amino free tetrazoles and their incorporation into peptides

Sureshbabu, V. V.; Venkataramanarao, R.; Naik, S. A.; Chennakirshnareddy, G.; Tetrahedron Letters, 2007, 48(39), 7038-7041

Link to article

Synthesis of the tetrasaccharide related to the repeating unit of the O-antigen from Azospirillum brasilense Jm125A2 in the form of its 2-aminoethyl glycoside

Synthesis of the tetrasaccharide repeating unit of the β-Kdo-containing exopolysaccharide from Burkholderia pseudomallei and B. cepacia complex

Laroussarie, A.; Barycza, B.; Andriamboavonjy, H.; Kenfack, M. T.; Bleriot, Y.; Gauthier, C.; J. Org. Chem., 2015, 80(20), 10386-10396

Link to article

Synthesis of the tetrasaccharide repeating unit of the O-antigen from Pseudomonas putida BIM B-1100 having rare D-Quip3NAc

Synthesis of the tetrasaccharide repeating unit of the O-glycan from the polar flagellum flagellin of Azospirillum brasilense Sp7

Pal, K. B.; Mukhopadhyay, B.; Carbohydrate Research, 2014, 400, 9-13

Link to article

Synthesis of the trisaccharide repeating unit of the lipopolysaccharide from Moritella viscosa strain M2-226

Pal, K. B.; Verma, P. R.; Gupta, T.; Mukhopadhyay, B.; Journal of Carbohydrate Chemistry, 2015, 34(4), 173-182

Link to article

Synthesis of two trisaccharides related to the hepatoprotective phenylethanoids leonoside E and F isolated from Leonurus japonicus Houtt

Budhadev, D.; Mukhopadhyay, B.; Carbohydrate Research, 2014, 384, 51-55

Link to article

Synthesis of unique scaffolds via Diels-Alder cycloadditions of tetrasubstituated cyclohexadienes

Jones, A. L.; Snyder, J. K.; Organic Letters, 2010, 12(7), 1592-1595

Link to article

Synthesis of unsaturated secondary amines by direct reductive amination of aliphatic aldehydes with nitroarenes over Au/Al₂O₃ catalyst in continuous flow mode

Synthesis of γ-valerolactone using a continuous-flow reactor

Tukacs, J. M.; Jones, R. V.; Darvas, F.; Dibo, G.; Lezsak, G.; Mika, L. T.; RSC Adv., 2013, 3, 16283-16287

Link to article

Synthesis, Properties, and Two-Dimensional Adsorption Characteristics of [6]Hexahelicene-7-carboxylic acid

Synthesis, SAR, and pharmacological characterization of brain penetrant P2X7 receptor antagonists

Savall, B. M.; Wu, D.; Angelis, M. D.; Carruhters, N. I.; Ao, H.; Wang, Q.; Lord, B.; Bharrachrya, A.; Letavic, M. A.; ACS Med. Chem. Lett., 2015, 6, 671-676

Link to article

Synthesis, structure–activity, and structure–stability relationships of 2‐substituted‐N‐(4‐oxo‐3‐oxetanyl) N‐acylethanolamine acid amidase (NAAA) inhibitors

Vitale, R.; Ottonello, G.; Petracca, R.; Bertozzi, S. M.; Ponzano, S.; Armirotti, A.; Berteotti, A.; Dionisi, M.; Cavalli, A.; Piomelli, D.; Bandiera, T.; Bertozzi, F.; ChemMedChem, 2014, 9, 323-336

Link to article

Synthetic multivalent ligands for cholera & cholera-like toxins: Protected cyclic neoglycopeptides

Kumar, V.; Yadav, N.; Kartha, K. P. R.; Carbohydrate Research, 2016, 431, 47-55

Link to article

Synthetic studies toward the C32–C46 segment of hemicalide. Assignment of the relative configuration of the C36–C42 subunit

Specklin, S.; Boissonnat, G.; Lecourt, C.; Sorin, G.; Lannou, M. I.; Ardisson, J.; Sautel, F.; Massiot, G.; Meyer, C.; Cossy, J.; Org. Lett., 2015, 17(10), 2446-2449

Link to article

Systematic evaluation of the palladium-catalyzed hydrogenation under flow conditions

Hattori, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Tetrahedron, 2014, 70(32), 4790-4798

Link to article

Tailoring nitrogen-doped carbons as hosts for single-atom catalysts

Buchele, S.; Chen, Z.; Mitchell, S.; Hauert, R.; Krumeich, F.; Perez-Ramirez, J.; ChemCatChem, 2019, 11(12), 2812-2820

Link to article

Taming hazardous chemistry by continuous flow technology

Movsisyan, M.; Delbeke, E. I. P.; Berton, J. K. E. T.; Battilocchio, C.; Ley, S. V.; Stevens, C. V.; Chem. Soc. Rev., 2016, 45, 489-4928

Link to article

Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry

Telescoped sequence of exothermic and endothermic reactions in multistep flow synthesis

Sharma, Y.; Nikam, A. V.; Kulkarni, A. A.; Org. Process Res. Dev., 2018, 23(2), 170-176

Link to article

Tetrahydroisoquinolinone‐based steroidomimetic and chimeric microtubule disruptors

Leese, M. P.; Jourdan, F. L.; Major, M. R.; Dohle, W.; Hamel, E.; Ferrandis, E.; Fiore, A.; Kasprzyk, P. G.; Potter, B. V. L.; ChemMedChem, 2014, 9(1), 85-108

Link to article

The assembly of integrated continuous flow platform for on-demand rosiglitazone and pioglitazone synthesis

The changing face of organic synthesis

Ley, S. V.; Baxendale, I. R.; Chimia, 2008, 62(3), 162-168

Link to article

The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors

Carter, C. F.; Baxendale, I. R.; Pavey, J. B. J.; Ley, S. V.; Org. Biomol. Chem., 2010, 8, 1588-1595

Link to article

The continuous synthesis and application of graphene supported palladium nanoparticles: a highly effective catalyst for Suzuki-Miyaura cross-coupling reactions

The Cooperative Research Centre for Cancer Therapeutics: bridging the gap between leading cancer research at Australia’s universities and developing novel cancer drugs

The development of poly(dendrimer)s for advanced processing

Gunning, J. P.; Levell, J. W.; Wyatt, M. F.; Burn, P. L.; Robertson, J.; Samuel, I. D. W.; Polym. Chem., 2010, 1, 730-738

Link to article

The dual reactivity of Weinreb amides applied to the late-stage divergent functionalisation of meso pyrrolidines

Boufroura, H.; Sevaille, L.; Gigant, N.; Drege, E.; Joseph, D.; New J. Chem., 2018, 42, 12403-12411

Link to article

The expanding utility of continuous flow hydrogenation

Cossar, P. J.; Hizartzidis, L.; Simone, M. I.; McCluskey A.; Gordon, C. P.; Org. Biomol. Chem., 2015, 13, 7119-7130

Link to article

The first case of competitive heterogeneously catalyzed hydrogenation using continuous-flow fixed-bed reactor system: Hydrogenation of binary mixtures of activated ketones on Pt-alumina and on Pt-alumina-cinchonidine catalysts

Szollosi, G.; Makra, Z.; Fulop, F.; Bartok, M.; Catalysis Letters, 2011, 141, 1616-1620

Link to article

The flow synthesis of heterocycles for natural product and medicinal chemistry applications

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Molecular Diversity, 2011, 15(3), 613-630

Link to article

The future of organic synthesis

Kundig, P.; Science, 2006, 314, 430-431

Link to article

The identification of indacaterol as an ultralong-acting inhaled β2-adrenoceptor agonist

Baur, F.; Beattie, D.; Beer, D.; Bentley, D.; Bradley, M.; Bruce, I.; Charlton, S. J.; Cuenoud, B.; Ernst, R.; Fairhurst, R. A.; Faller, B.; Farr, D.; Keller, T.; Fozard, J. R.; Fullerton, J.; Garman, S.; Hatto, J.; Hayden, C.; He, H.; Howes, C.; Janus, D.; Jiang, Z.; Lewis, C.; Loeuillet-Ritzler, F.; Moser, H.; Reilly, J.; Steward, A.; Sykes, D.; Tedaldi, L.; Trifilieff, A.; Tweed, M.; Watson, S.; Wissler, E.; Wyss, D.; J. Med. Chem., 2010, 53, 3675-3684

Link to article

The influence of linkages between 1-Hydroxy-2(1H)-pyridinone Coordinating Groups and a Tris(2-aminoethyl)amine core in a novel series of synthetic Hexadentate Iron(III) Chelators on antimicrobial activity

The integration of flow reactors into synthetic organic chemistry

Baxendale, I. R.; J. Chem. Technol. Biotechnol., 2013, 88, 519-552

Link to article

The microwave-to-flow paradigm: Translating high-temperature batch microwave chemistry to scalable continuous-flow processes

Glasnov, T. N.; Kappe, C. O.; Chem. Eur. J., 2011, 17, 11956-11968

Link to article

The recent advancement of hydrogenation technology and their implications for drug discovery research

Spadoni, C.; Jones, R.; Urge, L.; Darvas, F.; Chemistry Today, 2005, January/February, 36-39

The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches

Gordon, P. C.; Org. Biomol. Chem., 2018, 16, 180-196

Link to article

The role of flow in green chemistry and engineering

Newman, S. G.; Jensen, K. F.; Green Chem., 2013, 15, 1456-1472

Link to article

The role of water in catalytic biomass-based technologies to produce chemicals and fuels

Mika, L. T.; Csefalvay, E.; Horvath, I. T.; Catalysis Today, 2015, 247, 33-46

Link to article

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

Baumann, M.; Baxendale, I. R.; Beilstein J. Org. Chem., 2015, 11, 1194-1219

Link to article

The synthesis of azabicyclic heterocycles

Darout, E.; Basak, A.; Tetrahedron Letters, 2010, 51, 2998-3001

Link to article

The titanium-mediated double reductive cleavage of cyclic sulfonamides for the synthesis of aryl pyrrolidines

Khalifa, A.; Evans, P.; J. Org. Chem., 2019, 84(5), 2969-2975

Link to article

The use of a continuous flow-reactor employing a mixed hydrogen–liquid flow stream for the efficient reduction of imines to amines

Saaby, S.; Knudsen, K. R.; Ladlow, M., Ley, S. V.; Chem. Commun., 2005, 23, 2909-2911

Link to article

The use of gases in flow synthesis

Mallia, C. J.; Baxendale, I. R.; Org. Process Res. Dev., 2016, 20(2), 327-360

Link to article

Thermochemiluminescence-Based Sensitive Probes: Synthesis and Photophysical Characterization of Acridine-Containing 1,2-Dioxetanes Focusing on Fluorophore Push-Pull Effects

TiO₂–Fe₃O₄ Composite Systems—Preparation, Physicochemical Characterization, and an Attempt to Explain the Limitations That Arise in Catalytic Applications

Titanium nitride-nickel nanocomposite as heterogeneous catalyst for the hydrogenolysis of aryl ethers

Molinari, V.; Giordano, C.; Antonietti, M.; Esposito, D.; J. Am. Chem. Soc., 2014, 136(5), 1758-1761

Link to article

Tools for chemical synthesis in microsystems

Jensen, K. F.; Reizman, B. J.; Newman, S. G.; Lab. Chip, 2014, 14, 3206-3212

Link to article

Tools for efficient high-throughput synthesis

Chighine, A.; Sechi, G.; Bradley, M.; Drug Discovery Today, 2007, 12, 459-464

Link to article

Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2

Adams, D. R.; Tawati, S.; Berretta, G.; Rivas, P. L.; Baiget, J.; Jiang, Z.; Alsfouk, A.; MacKay, S. P.; Pyne, N.; Pyne, S.; J. Med. Chem., 2019, 62(7), 3658-3676

Link to article

Total chemical synthesis of PSMA-11: API for ⁶⁸Ga-PSMA-11 used for prostate cancer diagnosis

Total syntheses of the dipyrrolobenzoquinone (+)-terreusinone enabled by an evaluation of 4-methylpent-1-yn-3-ols in the Larock indole synthesis

Wang, C.; Sperry, J.; Tetrahedron, 2013, 69(23), 4563-4577

Link to article

Total synthesis and biological evaluation of tubulysin analogues

Colombo, R.; Wang, Z.; Han, J.; Balachandran, R.; Daghestani, H. N.; Camarco, D. P.; Vogt, A.; Day, B. W.; Mendel, D.; Wipf, P.; J. Org. Chem., 2016, 81(21), 10302-10320

Link to article

Total synthesis of (±)-monomorine

Le, T. Q.; Oliver, R. M.; Arcari, J. T.; Mitton-Fry, M. J.; Tetrahedron Letters, 2012, 53(42), 5660-5662

Link to article

Total synthesis of (±)-taiwaniaquinol F and related taiwaniaquinoids

Kakde, B. N.; Kumari, P.; Bisai, A.; J. Org. Chem., 2015, 80(20), 9889-9899

Link to article

Total synthesis of aignopsanes, a class of sesquiterpenes: (+)‐Aignopsanoic acid A, (−)‐methyl aignopsanoate A, and (−)‐isoaignopsanoic A

Burki, C.; Bonjoch, J.; Bradshaw, B.; Villa, G.; Renaud, P.; Chem. Eur. J., 2015, 21(1), 395-401

Link to article

Total Synthesis of Marine-Derived Azole Resistant Antifungal Agent (–)-Melearoride A and Antibiotic (–)-PF1163B

Total synthesis of the macrocyclic N-methyl enamides palmyrolide A and 2S-sanctolide A

Wadsworth, A. D.; Furkert, D. P.; Brimble, M. A.; J. Org. Chem., 2014, 79(22), 11179-11193

Link to article

Total synthesis, stereochemical assignment, and biological activity of chamuvarinin and structural analogues

Florence, G. J.; Morris, J. C.; Murray, R. G.; Vanga, R. R.; Osler, J. D.; Smith, T. K.; Chem. Eur. J., 2013, 19, 8309-8320

Link to article

Toward a continuous-flow synthesis of Boscalid®

Glasnov, T. N.; Kappe; C. O.; Adv. Synth. Catal., 2010, 352, 3089-3097

Link to article

Toward the synthesis of noroxymorphone via aerobic palladium-catalyzed continuous flow N-demethylation strategies

Gutmann, B.; Elsner, P.; Cox, D. P.; Weigl, U.; Roberge, D. M.; Kappe, C. O.; ACS Sustainable Chem. Eng., 2016, 4(11), 6048-6061

Link to article

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

Towards a continuous flow environment for lipase-catalyzed reactions

Itabaiana, I., Jr.; Soter de Mariz e Miranda, L.; de Souza, R. O. M. A.; Journal of Molecular Catalysis B: Enzymatic, 2013, 85-86, 1-9

Link to article

Towards industrial furfural conversion: Selectivity and stability of palladium and platinum catalysts under continuous flow regime

Towards the development of chromone-based MEK1/2 modulators

Redwan, I. N.; Dyrager, C.; Solano, C.; de Troconiz, G. F.; Voisin, L.; Bliman, D.; Meloche, S.; Grotli, M.; Eur. J. Med. Chem., 2014, 85, 127-138

Link to article

Transfer hydrogenation of levulinic acid under hydrothermal conditions catalyzed by sulfate as a temperature-switchable base

Kopetzki, D.; Antonietti, M.; Green Chem., 2010, 12, 656-660

Link to article

Transition-metal-catalyzed cyclopropanation of nonactivated alkenes in dibromomethane with triisobutylaluminium

Brunner, G.; Elmer, S.; Schroder, F.; Eur. J. Org. Chem., 2011, 4623-4633

Link to article

Translating high-temperature microwave chemistry to scalable continuous flow processes

Damm, M.; Glasnov, T. N.; Kappe, C. O.; Org. Process Res. Dev., 2010, 14(1), 215-224

Link to article

Treatments of lignocellulosic hydrolysates and continuous-flow hydrogenation of xylose to xylitol

Feher, A.; Feher, C.; Rozbach, M.; Racz, G.; Fekete, M.; Hegedus, L.; Barta, Z.; Chem. Eng. Technol., 2018, 41(3), 496-503

Link to article

Tunability and scalability of single-atom catalysts based on carbon nitride

Chen, Z.; Mitchell, S.; Krumeich, F.; Hauert, R.; Yakunin, S.; Kovalenko, M. V.; Perez-Ramirez, J.; ACS Sustainable. Chem. Eng., 2019, 7(5), 5223-5230

Link to article

Tunable Antibacterial Activity of a Polypropylene Fabric Coated with Bristling Ti3C2Tx MXene Flakes Coupling the Nanoblade Effect with ROS Generation

Tuning nano-nickel selectivity with tin in flow hydrogenation of 6-methyl-5-hepten-2-one by surface organometallic chemistry modification

Tuning the Selectivity of the Hydrogenation/Hydrogenolysis of 5-Hydroxymethylfurfural under Batch Multiphase and Continuous-Flow Conditions

Two step continuous-flow synthesis of benzocaine

Tyrosinases in organic chemistry: A versatile tool for the α‐arylation of β‐dicarbonyl compounds

Understanding flow chemistry for the production of active pharmaceutical ingredients

Unusual behavior in the reactivity of 5-substituted- 1H-tetrazoles in a resistively heated microreactor

Gutmann, B.; Glasnov, T. N.; Razzaq, T.; Goessler, W.; Roberge, D. M.; Kappe, C.O.; Beilstein J. Org. Chem., 2011, 7, 503-517

Link to article

Upgrading furanic platforms to α-enaminones: tunable continuous flow hydrogenation of biobased cyclopentenones

Use of Glycosyl Dithiocarbamates: Small Molecule ‘Turn-on’ Fluorescent Probe for Carbohydrate Binding Proteins

Use of Immobilized Amine Transaminase from Vibrio fluvialis under Flow Conditions for the Synthesis of (S)-1-(5-Fluoropyrimidin-2-yl)-ethanamine

Use of Vinyl Sulfides in Fischer Indole Reactions

User friendly and flexible Kiliani reaction on ketoses using microreaction technology

Cukalovic, A.; Monbaliu, J-C., M.; Heynderickx, G. J.; Stevens, C. V.; J. Flow Chem., 2012, 2(2), 43-46

Link to article

Using chemical probes to investigate the sub-inhibitory effects of azithromycin

Glansdorp, F. G.; Spandl, R. J.; Swatton, J. E.; Loiseleur, O.; Welch, M.; Spring, D. R.; Org. Biomol. Chem., 2008, 6, 4120-4124

Link to article

Using continuous processes to increase production

Anderson, N. G.; Org. Process Res. Dev., 2012, 16(5), 852-869

Link to article

Using Oxygen as the Primary Oxidant in a Continuous Process: Application to the Development of an Efficient Route to AZD4635

Valorization of humins-extracted 5-methoxymethylfurfural: Toward high added value furanics via continuous flow catalytic hydrogenation

Pfab, E.; Filiciotto, L.; Romero, A. A.; Luque, R.; Ind. Eng. Chem. Res., 2019, 58(35), 16065-16070

Link to article

Valorization of lignin waste from hydrothermal treatment of biomass

Chieffi, G.; Fechler, N.; Esposito, D.; RSC Adv., 2015, 5(78), 63691-63696

Link to article

Versatile dual hydrogenation-oxidation nanocatalysts for the aqueous transformation of biomass-derived platform molecules

Garcia-Suarez, E. J.; Balu, A. M.; Tristany, M.; Garcia, A. B.; Philippot, K.; Luque, R.; Green Chem., 2012, 14, 1434-1439

Link to article

Versatile low-loaded mechanochemically synthesized supported iron oxide nanoparticles for continuous flow alkylations

Balu, A. M.; Pineda, A.; Obermayer, D.; Romero, A. A., Kappe, C. O.; Luque, R.; RSC Adv., 2013, 3, 16292-16295

Link to article

Visible-light-mediated iodoperfluoroalkylation of alkenes in flow and its application to the synthesis of a key Fulvestrant intermediate

Visually following the hydrogenation of curcumin to tetrahydrocurcumin in a natural product experiment that enhances student understanding of NMR spectroscopy

Wagner, C. E.; Marshall, P. A.; Cahill, T. M.; Mohamed, Z.; J. Chem. Educ., 2013, 90(7), 930-933

Link to article

VUT-MK142: a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes

Koley, M.; Mike, A. K.; Heher, P.; Koenig, X.; Schon, M.; Schnurch, M.; Hilber, K.; Weitzer, G.; Mihovilovic, M. D.; Med. Chem. Commun., 2013, 4, 1189-1195

Link to article