Publications

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ThalesNano has set a new standard for laboratory-scale continuous flow reactions, especially on the field of hydrogenation. Our instruments have been used all around the world for a wide range of applications and have been featured in numerous scientific publications.

Browse our poblications in alphabetical order below, filter by catalyst, device, industry or reaction type, or download the complete list.

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Browse the list of all published scientific papers, last update: 2023/10/17
950+
publications
1900+
instruments globally
21
years of experience

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Browse publications

1,3,5-Trisubstituted pyrazoles as potent negative allosteric modulators of the mGlu2/3 receptors

Van Gool, M.; Alonso De Diego, S. A.; Delgado, O.; Trabanco, A. A.; Jourdan, F.; Macdonald, G. J.; Somers, M.; Ver Donck, L.; ChemMedChem, 2017, 12(12), 905-912

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1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activity

Abdel-Hamid, M. K.; Macgregor, K. A.; Odell, L. R.; Chau, N.; Mariana, A.; Whiting, A.; Robinson, P. J.; McCluskey, A.; Org. Biomol. Chem., 2015, 13, 8016-8028

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2,7-Pyrrolo[2,1-f][1,2,4]triazines as JAK2 inhibitors: modification of target structure to minimize reactive metabolite formation

Weinberg, L. R.; Albom, M. S.; Angeles, T. S.; Breslin, H. J.; Gingrich, D. E.; Huang, Z.; Lisko, J. G.; Mason, J. L.; Milkiewicz, K. L.; Thieu, T. V.; Underiner, T.L .; Wells, G. J.; Wells-Knecht, K. J.; Dorsey, B. D.; Bioorg. Med. Chem. Lett., 2011, 21(4), 7325-7330Link to article

3‐Aminoazetidin‐2‐one derivatives as N‐acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration

Fiasella, A.; Nuzzi, A.; Summa, M.; Armirotti, A.; Tarozzo, G.; Tarzia, G.; Mor, M.; Bertozzi, F.; Bandiera, T.; Piomelli, D.; ChemMedChem, 2014, 9(7), 1602-1614

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3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Ferrins, L.; Rahmani, R.; Sykes, M. L.; Jones, A. J.; Avery, V. M.; Teston, E.; Almohaywi, B.; Yin, J.; Smith, J.; Hyland, C.; White, K. L.; Ryan, E.; Campbell, M.; Charman, S. A.; Kaiser, M.; Baell, J. B.; Eur. J. Med. Chem., 2013, 66, 450-465

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3-Substituted xanthines as promising candidates for quadruplex formation: computational, synthetic and analytical studies

Szolomajer, J.; Paragi, G.; Batta, Gy.; Guerra, F. C.; Bickelhaupt, F. M.; Kele, Z.; Padar, P.; Kupihar, Z.; Kovacs, L.; New Journal of Chemistry, 2011, 35, 476-482

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4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as high-affinity non-imidazole histamine H3 receptor agonists with in vivo central nervous system activity

Wagner, G. et al; J. Med. Chem., 2019, 62(23), 10848-10866

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4′-C-methyl-2-deoxyadenosine and 4-C-ethyl-2-deoxyadenosine inhibit HIV-1 replication

Vu, B. C.; Boyer, P. L.; Siddiqui, M. A.; Marquez, V. E.; Hughes, S. H.; Antimicrobial Agents and Chemotheraphy, 2011, 55(5), 2379-2389

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4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-based P2X7 receptor antagonists: optimization of pharmacokinetic properties leading to the identification of a clinical candidate

Letavic, M. A.; Savall, B. M.; Allison, B. D.; Aluisio, L.; Andres, J. I.; De Angelis, M.; Ao, H.; Beauchamp, D. A.; Bonaventure, P.; Bryant, S.; Carruthers, N. I.; Ceusters, M.; Coe, K. J.; Dvorak, C. A.; Fraser, I. C.; Gelin, C. F.; Koudriakova, T.; Liang, J.; Lord, B.; Lovenberg, T. W.; Otieno, M. A.; Schoetens, F.; Swanson, D. M.; Wang, Q.; Wickenden, A. D.; Bhattacharya, A.; J. Med. Chem., 2017, 60(11), 4559-4572

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4b,5,6,9-Tetrahydro-7H-dibenzo[c,e]pyrrolo[1,2-a]azepin-7-one

Boichenko, M. A. et al.; Molbank, 2019, 2019, M1061

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Synthesis, antiplasmodial activity and in silico molecular docking study of pinocembrin and its analogs

Melaku, Y. et al.; BMC Chemistry, 2022, 16:36

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Synthesis of 12β-methyl-18-nor-avicholic acid analogues as potential TGR5 agonists

Ure, E. M. et al.; Org. Biomol. Chem., 2022, 20, 3511-3527

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α-1,4-Galactosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins

Simerska, P.; Christie, M. P.; Goodwin, D.; Jen, F. E-C.; Jennings, M. P.; Toth, I.; Journal of Molecular Catalysis B: Enzymatic, 2013, 97, 196-202

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A benchtop continuous flow reactor: a solution to the hazards posed by gas cylinder based hydrogenation

Dorman, G.; Kocsis, L.; Jones, R.; Darvas, F.; Journal of Chemical Health and Safety, 2013, 20(4), 3-8

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A comparative assessment study of known small-molecule Keap1−Nrf2 protein–protein interaction inhibitors: Chemical synthesis, binding properties, and cellular activity

Tran, K. T.; Pallesen, J. S.; Solbak, S. M. O.; Narayanan, D.; Baig, A.; Zang, J.; Aguayo-Orozco, A.; Carmona, R. M. C.; Garcia, A. D.; Bach, A.; J. Med. Chem., 2019, 62(17), 8028-8052

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A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Gambarcorta, G. et al.; Beilstein J. Org. Chem., 2021, 17, 1181-1312

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A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

Baumann, M.; Baxendale, I. R.; Deplante, F.; Beilstein J. Org. Chem., 2017, 13, 2549-2560

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A concise stereoselective synthesis of pterosin B

Dexter, H. R.; Allen, E.; Williams, D. M.; Tetrahedron Letters, 2018, 59(49), 4323-4325

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A continuous-flow approach to palladium-catalyzed alkoxycarbonylation reactions

Kelly, C. B.; Lee, C. (X.); Mercadante, M. A.; Leadbeater N. E.; Org. Process Res. Dev., 2011, 15(3), 717-720

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A continuous-flow microwave reactor for conducting high-temperature and high-pressure chemical reactions

Sauks, J. M.; Mallik, D.; Lawryshyn, Y.; Bender, T.; Organ, M.; Org. Process Res. Dev., 2014, 18(11), 1310-1314

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A continuous flow process for the green and sustainable production of N-alkyl imidazoles

Fekete, M.; Kocsis L.; Dorman, G.; Jones, R. V.; Darvas, F.; Green Processing and Synthesis, 2016, 5(3), 239-246

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A continuous flow process for the production of 2,5-dimethylfuran from fructose using (non-noble metal based) heterogeneous catalysis

Braun, M.; Antonietti, M.; Green Chemistry, 2017, 19, 3813-3819

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A continuous flow strategy for the facile synthesis and elaboration of semi-saturated heterobicyclic fragments

Luise, N.; Wyatt, E. W.; Tarver, G. J.; Wyatt, P. G.; Eur. J. Org. Chem., 2018, 2019(6), 1341-1349

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A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

Viviano, M.; Milite, C.; Rescigno, D.; Castellano, S.; Sbardella, G.; RSC Adv., 2015, 5, 1268-1273

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A continuous flow system for asymmetric hydrogenation using supported chiral catalysts

Madarasz, J.; Farkas, G.; Balogh, S.; Szollosy, A.; Kovacs, J.; Darvas, F.; Urge, L.; Bakos, J.; J. Flow Chem., 2011, 1(2), 62-67

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A continuous-flow, two-step, metal-free process for the synthesis of differently substituted chiral 1,2-diamino derivatives

Pirola, M.; Compostella, M. E.; Raimondi, L.; Puglisi, A.; Benaglia, M.; Synthesis, 2018, 50, 1430-1438

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A continuous process for glyoxal valorisation using tailored Lewis-acid zeolite catalysts

Dapsens, P. Y.; Mondelli, C.; Kusema, B. T.; Verel, R., Perez-Ramirez, J.; Green Chemistry, 2014, 16, 1176-1186

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A Continuous‐Flow Process for Palladium‐Catalyzed Olefin Cleavage by using Oxygen within the Explosive Regime

Hone, C. A. et al.; ChemCatChem, 2017, 9, 3298-3302

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A convenient total synthesis of PSMA-617: A prostate specific membrane antigen (PSMA) ligand for prostate cancer endotherapeutic applications

Kumar, K. S. A. et al.; Eur. J. Med. Chem. Rep., 2022, 6, 100084

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A Facile hybrid ‘flow and batch’ access to substituted 3,4-dihydro-2H-benzo[b][1,4]oxazinones

Lin, A. J. S. et al.; Org. Biomol. Chem., 2016, 14, 8732-8742

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A facile, protic ionic liquid route to N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides and N-substituted 3-oxoisoindoline-4-carboxylic acids

Gordon, C. P.; Byrne, N.; McCluskey, A.; Green Chem., 2010, 12, 1000-1006

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A flexible approach to 6,5-benzannulated spiroketals

Wilson, Z. E.; Hubert, J. G.; Brimble, M. A.; Eur. J. Org. Chem., 2011, 2011(20-21), 3938-3945

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A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core

Hay, D. A.; Adam, F. M.; Bish, G.; Calo, F.; Dixon, R.; Fray, M. J.; Hitchin, J.; Jones, P.; Paradowski, M.; Parsons, G. C.; Proctor, K. J. W.; Pryde, D. C.; Smith, N. N.; Tran, T. D.; Tetrahedron Letters, 2011, 52(44), 5728-5732

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A flow-based synthesis of telmisartan

Martin, A. D.; Siamaki, A. R.; Belecki, K.; Gupton, B. F.; J. Flow Chem., 2015, 5(3), 145-147

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A flow-based transition-metal-catalysed hydrogenolysis strategy to facilitate peptide side-chain deprotection

Menti-Platten, M. et al.; Org. Biomol. Chem., 2022, 20, 106-112

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A flow chemistry route to 2-phenyl-3-(1H-pyrrol-2-yl)propan-1-amines

Tarleton, M.; McCluskey, A.; Tetrahedron Letters, 2011, 52(14), 1583-1586

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A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S.; Tranmer, G. K.; Chem. Commun., 2006, 2566-2568

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A flow process using microreactors for the preparation of a quinolone derivative as a potent 5HT1B antagonist

Qian, Z.; Baxendale, I. R.; Ley, S. V.; Synlett, 2010, 4, 505-508

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A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K.; Chem. Commun., 2006, 4835-4837

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A gram-scale batch and flow total synthesis of perhydrohistrionicotoxin

Brasholz, M.; Macdonald, J. M.; Saubern, S.; Ryan, J. H.; Holmes, A. B.; Chem. Eur. J., 2010, 16(37), 11471-11480

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A Green Process for the Preparation of Bis(2,2,2-trifluoroethyl) Methylphosphonate

Molnar, K. et al.; Org. Process Res. Dev., 2017, 21, 1985-1989

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A High‐Throughput Composite Catalyst based on Nickel Carbon Cubes for the Hydrogenation of 5‐Hydroxymethylfurfural to 2,5‐Dimethylfuran

Mani, C. M. et al.; ChemCatChem, 2017, 9, 3388-3394

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A Meldrum’s Acid Based Multicomponent Synthesis of N-Fmoc isoxazolidin-5-ones: Entry to N-Fmoc-β-amino Acids

Le Foll Devaux, A. et al.; Eur. J. Org. Chem., 2017, 3265-3273

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A method to identify best available technologies (BAT) for hydrogenation reactors in the pharmaceutical industry

Van Le Doan, T.; Stavarek, P.; de Bellefon, C.; J. Flow Chem., 2012, 2(3), 77-82

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A modular, low footprint and scalable flow platform for the expedient α-aminohydroxylation of enolizable ketones

Kassin, V-E. H. et al.; Green Chemistry, 2021, 23, 2336-2351

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A modular synthesis of teraryl‐based α‐helix mimetics, part 2: Synthesis of 5‐pyridine boronic acid pinacol ester building blocks with amino acid side chains in 3‐position

Peters, M.; Trobe, M.; Breinbauer, R.; Chem. Eur. J., 2013, 19(7), 2450-2456

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A multi-step continuous flow synthesis of pomalidomide

Ivanova, M. et al.; J. Flow Chem., 2022, https://doi.org/10.1007/s41981-022-00223-3

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A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands

Petersen, T. P.; Ritzen, A.; Ulven, T.; Org. Lett., 2009, 11(22), 5134-5137

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A novel agonist of the type 1 lysophosphatidic acid receptor (LPA1), UCM-05194, shows efficacy in neuropathic pain amelioration

Gonzalez Gil, I.; Zian, D.; Vazquez-Villa, H.; Hernandez-Torres, G.; Martinez, R. F.; Khiar-Fernandez, N.; Rivera, R.; Kihara, Y.; Devesa, I.; Mathivanan, S.; Rosell del Valle, C.; Zambrana-Infantes, E.; Puigdomenech, M.; Cincilla, G.; Sanchez-Martinez, M.; Rodriguez de Fonseca, F.; Ferrer-Montiel, A.; Chun, J.; Lopez-Vales, R.; Lopez-Rodriguez, M. L.; Ortega-Gutierrez, S.; J. med. Chem., 2019, accepted manuscript

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A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells

Kim, J.; Moon, S. H.; Kim, B. T.; Chae, C. H.; Lee, J. Y.; Kim, S. H.; PLoS One, 2014, 9(10), e110180

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A novel method for high-throughput reduction of compounds through automated sequential injection into a continuous-flow microfluidic reactor

Jones, R.; Godorhazy, L.; Szalay, D.; Gerencser, J.; Dorman, G.; Urge, L.; Darvas, F.; QSAR Comb. Sci., 2005, 24(6), 722-727

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A novel nano-palladium catalyst for continuous-flow chemoselective hydrogenation reactions

Goszewska, I. et al.; Catalysis Communications, 2017, 94, 65-68

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A Novel One-pot Benzimidazole Ring Formation via a Continuous Flow Selective Reductive Cyclization Method

Szabo, B. et al.; Curr. Org. Chem., 2018, 22(19), 1940-1944

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A novel pathway for the thermolysis of N-nitrosoanthranilates using flash vacuum pyrolysis leading to 7-aminophthalides

Zlatkovic, D. et al.; Org. Biomol. Chem., 2020, 18, 8371-8375

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A practical and benign synthesis of amines through Pd@mpg-C3N4 catalyzed reduction of nitriles

Li, Y.; Gong, Y.; Xu, X.; Zhang, P.; Li, H.; Wang, Y.; Catalysis Communications, 2012, 28, 9-12

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A remote-controlled adaptive medchem lab: an innovative approach to enable drug discovery in the 21st Century

Godfrey, A. G.; Masquelin, T.; Hemmerle, H.; Drug Discovery Today, 2013, 18(17-18), 795-802

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A safe and compact flow platform for the neutralization of a mustard gas simulant with air and light

Emmanuel, N. et al.; Green Chemistry, 2020, 22, 4105-4115

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A safe and selective method for reduction of 2-nitrophenylacetic acid systems to N-aryl hydroxamic acids using continuous flow hydrogenation

Ichire, O.; Jans, P.; Parfenov, G.; Dounay, A. B.; Tetrahedron Letters, 2017, 58(6), 582-585

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A scalable two-step continuous flow synthesis of nabumetone and related 4-aryl-2-butanones

Viviano, M.; Glasnov, T. N.; Reichard, B.; Tekautz, B.; Kappe, C. O.; Org. Process Res. Dev., 2011, 15, 858-870

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A simple chemical model for clathrate hydrate inhibition by polyvinylcaprolactam

Davenport, J. R.; Musa, O. M.; Paterson, M. J.; Piepenbrock, M. O. M.; Fucke, K.; Steed, J. W.; Chem. Commun., 2011, 47, 9891-9893

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A simple, efficient, and selective deuteration via a flow chemistry approach

Mandity, I. M.; Martinek, T. A.; Darvas, F.; Fulop, F.; Tetrahedron Letters, 2009, 50, 4372-4374

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A small footprint oxycodone generator based on continuous flow technology and real-time analytics

Sommer, F. et al.; J. Flow Chem., 2021, 11, 707-715

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A step forward towards sustainable aerobic alcohol oxidation: new and revised catalysts based on transition metals on solid supports

Parmeggiani, C. et al.; Green Chemistry, 2017, 19, 2030-2050

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A stereoselective, catalytic strategy for the in-flow synthesis of advanced precursors of rasagiline and tamsulosin

Brenna, D.; Pirola, M.; Raimondi, L.; Burke, A. J.; Benaglia, M.; Bioorg. Med. Chem., 2017, 25(23), 6242-6247

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A streamlined synthesis of the neurosteroid 3β-methoxypregnenolone assisted by a statistical experimental design and automation

Mancino, V. et al.; React. Chem. Eng., 2020, 5, 300-307

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A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors

Gordon, C. P.; Dalton, N.; Vandegraaff N.; Deadman, J.; Rhodes, D. I.; Coates, J. A.; Pyne, S. G.; Griffith, R.; Bremner, J. B.; Keller, P. A.; Tetrahedron, 2018, 74(12), 1253-1268

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A sustainable and chemoselective continuous flow hydrogenation of functionalized 2-azetines to azetidines

Graziano, E. et al.; Tetrahedron Green Chem., 2023, 1, 100003

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A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir

Dalla-Vechia, L.; Reichart, B.; Glasnov, T. N.; Miranda, L. S. M.; Kappe, C. O.; de Souza, R. O. M. A.; Org. Biomol. Chem., 2013, 11, 6806-6813

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A ‘turn-on’ fluorescence glycosyl dithiocarbamate probe for selective fluoride sensing in aqueous medium

Das, R.; Mishra, B.; Mukhopadhyay, B.; Synlett, 2018, 29(15), 2001-2005

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A two‐step continuous‐flow synthesis of N‐(2‐aminoethyl)acylamides through ring‐opening/hydrogenation of oxazolines

Gutmann, B.; Roduit, J. P.; Roberge, D.; Kappe, C. O.; Chem. Eur. J., 2011, 17, 13146-13150

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A versatile biobased continuous flow strategy for the production of 3-butene-1,2-diol and vinyl ethylene carbonate from erythritol

Tshibalonza, N. N.; Gerardy, R.; Alsafra, Z.; Eppe, G.; Monbaliu, J-C. M.; Green Chem., 2018, 20, 5147-5157

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A versatile de novo synthesis of legionaminic acid and 4-epi-legionaminic acid starting from D-serine

Gintner, M.; Yoneda, Y.; Schmölzer, C.; Denner, C.; Kahlig, H.; Schmid, W.; Carbohydrate Research, 2019, 474, 34-42

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A Warburg effect targeting vector designed to increase the uptake of compounds by cancer cells demonstrates glucose and hypoxia dependent uptake

Glenister, A.; Simone, M. I.; Hambley, T. W.; PLos One, 2019, online article

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Accelerating Biocatalytic Hydrogenations using the H-Cube Flow Reactor

Poznansky, B. et al.; Catalysis, 2020, Working paper

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Access to optically active 3‐aminopiperidines by ring expansion of prolinols: Thermodynamic versus kinetic control

Cochi, A. ; Pardo, D. G.; Cossy, J.; Eur. J. Org. Chem., 2012, 2012(10), 2023-2040

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Accessing novel process windows in a high‐temperature/pressure capillary flow reactor

Razzaq, T.; Glasnov, T. N.; Kappe, C. O.; Chem. Eng. Technol., 2009, 32(11), 1702-1716

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Activity of continuous flow synthesized Pd-based nanocatalysts in the flow hydroconversion of furfural

Garcia-Olmo, A. J.; Yepez, A.; Balu, A. M.; Prinsen, P.; Garcia, A.; Maziere, A.; Len, C.; Luque, R.; Tetrahedrom, 2017, 73(38), 5599-5604

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Acylguanidine beta secretase 1 inhibitors: a combined experimental and free energy perturbation study

Keranen, H.; Perez-Benito, L.; Ciordia, M.; Delgado, F.; Steinbrecher, T. B.; Oehlrich, D.; van Vlijmen, H. W. T.; Trabanco, A. A.; Tresadern, G.; J. Chem. Theory Comput., 2017, 13, 1439-1453

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Adaptive and automated system-optimization for heterogeneous flow-hydrogenation reactions

Fabry, D. C.; Heddrich, S.; Sugiono, E.; Liauw, M. A.; Rueping, M.; React. Chem. Eng., 2019, 4, 1486-1491

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Additive manufacturing technologies: 3D printing in organic synthesis

Rossi, S.; Puglisi, A.; Banglia, M.; ChemCatChem, 2018, 10(7), 1512-1525

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Advanced In-Line Purification Technologies in Multistep Continuous Flow Pharmaceutical Synthesis

Lei, Z. et al.; Org. Process Res. Dev., 2023, Accepted manuscript

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Advanced Real-Time Process Analyticsfor Multistep Synthesis in Continuous Flow

Sagmeister, P. et al.; Angew. Chem. Int. Ed., 2021, 60, 8139-8148

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Aerobic flow oxidation of alcohols in water catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

Osako, T.; Torii, K.; Uozumi, Y.; RSC Adv., 2015, 5, 2647-2654

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Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries

Gavriilidis, A. et al.; React. Chem. Eng., 2016, 1, 595-612

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Ag–In–Zn–S Quaternary Nanocrystals Prepared from InCl2 Precursor: Photophysical and Spectroscopic Properties and Application as Visible Light Photocatalysts of Aromatic Aldehyde Photoreduction

Kowalik, P. et al.; Chem. Mater., 2023, Accepted manuscript

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Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors

Bamborough, P. et al.; J. Med. Chem., 2018, 18, 8321-8336

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Alkyne–azide cycloadditions with copper powder in a high‐pressure continuous‐flow reactor: High‐temperature conditions versus the role of additives

Otvos, S. B.; Mandity, I. M.; Kiss, L.; Fulop, F.; Chem. Asian J., 2013, 8(4), 800-808

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Ambient Processed rGO/Ti3CNTx MXene Thin Film with High Oxidation Stability, Photosensitivity, and Self-Cleaning Potential

Purbayanto, M. A. K. et al.; ACS Appl. Nano Mater., 2023, Accepted manuscript

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Amino-Modified Silica-Supported Copper-Palladium Alloy. Synthesis and Use in Selective Hydrogenation of Disubstituted Nitroarenes in a Flow Micro Reactor

Nurmukhametova, A. T. et al.; Russian J. Org. Chem., 2019, 55, 1-6

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Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitor

Ponomarev, K. Yu.; Suslov, E. V.; Zakharenko, A. L.; Zakharova, O. D.; Rogachev, A. D.; Korchagina, D. V.; Zafar, A.; Reynisson, J.; Nefedov, A. A.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I.; Bioorg. Chem., 2018, 76, 392-399

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Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization

Whelligan, D. K.; Solanki, S.; Taylor, D.; Thomson, D. W.; Cheung, K. J.; Boxall, K.; Mas-Droux, C.; Barillari, C.; Burns, S.; Grummitt, C. G.; Collins, I.; van Montfort, E. L. M.; Aherne, G. W.; Bayliss, R.; Hoelder, S.; J. Med. Chem., 2010, 53, 7682-7698

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An Enantioselective Approach to Pinguisane Sesquiterpenes: Total Synthesis of (–)-Pinguisenol and (–)-Isonaviculol

Singh, S. et al.; Eur. J. Org. Chem., 2017, 2824-2830

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An alternative route for fondaparinux sodium synthesis via selective hydrogenations and sulfation of appropriate pentasaccharides

Manikowski, A.; Koziol, A.; Czajkowska-Wojciechowska, E.; Carbohydrate Research, 2012, 361, 155-161

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An effective synthesis of polynuclear tetraamines, monomers for polyheteroarylenes

Begunov, R. S. et al.; Russian Chemical Bulletin, 2018, 67, 1072-1077

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An efficient and more sustainable one-step continuous-flow multicomponent synthesis approach to chromene derivatives

Vaddula, B. R.; Yalla, S.; Gonzalez, M. A.; J. Flow Chem., 2015, 5(3), 172-177

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An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process

Sedelmeier, J.; Ley, S. V.; Baxendale, I. R.; Green Chem., 2009, 11, 683-685

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An efficient continuous flow approach to furnish furan-based biaryls

Trinh, T. N.; Hizartzidis, L.; Lin, A. J. S.; Harman, D. G.; McCluskey, A.; Gordon, C. P.; Org. Biomol. Chem., 2014, 12, 9562-9571

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An imidazolium-based organopalladium-functionalized organic–inorganic hybrid silica promotes one-pot tandem Suzuki cross coupling–reduction of haloacetophenones and arylboronic acids

Zhang, D.; Cheng, T.; Liu, G.; Applied Catal. B: Environmental, 2015, 174-175, 344-349

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An Integrated Continuous-Flow Synthesis of a Key Oxazolidine Intermediate to Noroxymorphone from Naturally Occurring Opioids

Mata, A. et al.; Eur. J. Org. Chem., 2017, 6505-6510

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An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor

Russell, C.; Lin, A. J. S.; Hains, P.; Simone, M. I.; Robinson, P. J.; McCluskey, A.; RSC Adv., 2015, 5, 93433-93437

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An Intramolecular Diels–Alder Furan (IMDAF) Approach towards the Synthesis of Isoindolo[2,1-a]quinazolines and Isoindolo-[1,2-b]quinazolines

Revutskaya E. L. et al.; Synthesis, 2017, 49(16), 3749-3767

Link to article

An orally bioavailable, indole-3-glyoxylamide based series of tubulin polymerization inhibitors showing tumor growth inhibition in a mouse xenograft model of head and neck cancer

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Anthranilic acid, the new player in the ensemble of aromatic residue labeling precursor compounds

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Neeharika, T. S. V. R.; Rani, K. N. P.; Rao, K. V. S. A.; Kumar, T. P.; Prasad, R. B. N.; Bulletin of Chemical Reaction Engineering & Catalysis, 2013, 8(2), 154-159

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Aqueous Asymmetric 1,4-Addition of Arylboronic Acids to Enones Catalyzed by an Amphiphilic Resin-Supported Chiral Diene Rhodium Complex under Batch and Continuous-Flow Conditions

Shen, G. et al.; J. Org. Chem., 2018, 83, 7380-7387

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Osako, T.; Kaiser, R.; Torii, K.; Uozumi, Y.; Synlett, 2019, 30, 961-966

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Assessing a sustainable manufacturing route to lapatinib

Stark, R. T. et al.; React. Chem. Eng., 2022, Advance article

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Assignment of vibrational circular dichroism cross‐referenced electronic circular dichroism spectra of flexible foldamer building blocks: Towards assigning pure chiroptical properties of foldamers

Farkas, V.; Nagy, A.; Menyhard, D. K.; Perczel, A.; Chem. Eur. J., 2019, 25(65), 14890-14900

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Asymmetric aldol reaction in a continuous-flow reactor catalyzed by a highly reusable heterogeneous peptide

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Asymmetric hydrogenation of C=C double bonds using Rh-complex under homogeneous, heterogeneous and continuous mode conditions

Balogh S.; Farkas, G.; Madarasz, J.; Szollosy, A.; Kovacs, J.; Darvas, F.; Urge L.; Bakos, J.; Green Chem., 2012, 14, 1146-1151

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Asymmetric Mannich reaction of dicarbonyl compounds with α-amido sulfones catalyzed by cinchona alkaloids and synthesis of chiral dihydropyrimidones

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Asymmetric Synthesis of γ-Amino-Functionalised Vinyl Sulfones: De Novo Preparation of Cysteine Protease Inhibitors

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Asymmetric Synthesis of Trisubstituted Piperidines via Biocatalytic Transamination and Diastereoselective Enamine or Imine Reduction

Petermeier, P. et al.; Adv. Synth. Catal., 2023, Early view

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Asymmetric Total Synthesis of (-)-Erogorgiaene and Its C-11 Epimer and Investigation of Their Antimycobacterial Activity

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Atomic Cu on nanodiamond-based sp2/sp3 hybrid nanostructures for selective hydrogenation of phenylacetylene

Sun, Y.; Luo, B.; Xu, S.; Guo, W.; Huang, X.; Shao, L.; Chemical Physics Letters, 2019, 723, 39-43

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Automated and continuous synthesis of drug substances

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Automated flow and real-time analytics approach for screening functional group tolerance in heterogeneous catalytic reactions

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Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

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Autonomous continuous flow reactor synthesis for scalable atom-precision

Sumpter, B. G. et al.; Carbon Trends, 2023, 10, 100234

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Aziridine ring opening for the synthesis of sphingolipid analogues: Inhibitors of sphingolipid-metabolizing enzymes

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Base-Promoted Formal (3 + 2) Cycloaddition of α-Halohydroxamates with Electron-Deficient Alkenyl-iminoindolines To Synthesize Spiro-indolinepyrrolidinones

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Batch and Continuous-Flow Huisgen 1,3-Dipolar Cycloadditions with an Amphiphilic Resin-Supported Triazine-Based Polyethyleneamine Dendrimer Copper Catalyst

Pan, S. et al.; ACS Sustainable Chem. Eng., 2017, 5, 10722-10734

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Batch and continuous-flow room temperature furfural acetalization with ethanol over aluminophosphate (APAl) catalysts for biofuels production

Ratthiwal, J. et al.; Fuel, 2023, 332, 126049

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Batch and flow hydrotreatment of water contaminated by trichloroethylene on active carbon supported nickel catalysts

Kaminska, I. I.; Kowalewski, E.; Lisovytskiy, D.; Blachucki, W.; Rarog-Pilecka, W.; Lomot, D.; Srebowata, A.; Applied Catalysis A: General, 2019, 582, 117110

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Batch versus continuous flow performance of supported mono‐ and bimetallic nickel catalysts for catalytic transfer hydrogenation of furfural in isopropanol

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Batch‐ and Continuous‐Flow Aerobic Oxidation of 14‐Hydroxy Opioids to 1,3‐Oxazolidines—A Concise Synthesis of Noroxymorphone

Gutmann, B. et al.; Chem. Eur. J., 2016, 22, 10393-10398

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Benchmarking immobilized di- and triarylphosphine palladium catalysts for continuous-flow cross-coupling reactions: Efficiency, durability, and metal leaching studies

Greco, R.; Goessler, W.; Cantillo, D.; Kappe, C. O.; ACS Catal., 2015, 5, 1303-1312

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Benign-by-design orange peel-templated nanocatalysts for continuous flow conversion of levulinic acid to N-heterocycles

Rodriguez-Padron, D.; Puente-Santiago, A. R.; Balu, A. M.; Romero, A. A.; Munoz-Batista, M. J.; Luque, R.; ACS Sustainable Chem. Eng., 2018, 6(12), 16637-16644

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Benzo[d]imidazole transient receptor potential vanilloid 1 antagonists for the treatment of pain: Discovery of trans-2-(2-{2-[2-(4-trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

Parsons, W. H.; Calvo, R. R.; Cheung, W.; Lee, Y. K.; Patel, S.; Liu, J.; Youngman, M. A.; Dax, S. L.; Stone, D.; Qin, N.; Hutchinson, T.; Lubin, M. L.; Zhang, S. P.; Finley, M.; Liu, Y.; Brandt, M. R.; Flores, C. M.; Player, M. R.; J. Med. Chem., 2015, 58(9), 3859-3874

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Benzoxazinone synthesis via Passerini–Smiles couplings

Martinand-Lurin, E.; El Kaim, L.; Grimaud, L.; Tetrahedron Letters, 2014, 55(37), 5144-5146

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Benzoxazolone carboxamides as potent acid ceramidase inhibitors: Synthesis and structure–activity relationship (SAR) studies

Bach, A.; Pizzirani, D.; Realini, N.; Vozella, V.; Russo, D.; Penna, I.; Melzig, L.; Scarpelli, R.; Piomelli, D.; J. Med. Chem., 2015, 58(23), 9258-9272

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Beyond electrolysis: old challenges and new concepts of electricity-driven chemical reactors

Nigar, H. et al.; React. Chem. Eng., 2020, 5, 1005

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Beyond the use of modifiers in selective alkyne hydrogenation: silver and gold nanocatalysts in flow mode for sustainable alkene production

Vile, G.; Perez-Ramirez, J.; Nanoscale, 2014, 6, 13476-13482

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Bicyclic naphthenic acids in oil sands process water: Identification by comprehensive multidimensional gas chromatography–mass spectrometry

Wilde, M. J.; West, C. E.; Scarlett, A. G.; Jones, D.; Frank, R. A.; Hewitt, L. M.; Rowland, S. J.; Journal of Chromatography A, 2015, 1378, 74-87

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Bifunctional Ruthenium Nanoparticle-SILP Catalysts (RuNPs@SILP) for the Hydrodeoxygenation of Eucalyptol under Batch and Continuous Flow Conditions

Luska, K. L. et al.; ACS Sustainable Chem. Eng., 2016, 4(11), 6186-6192

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Bifunctional thiourea-modified polymers of intrinsic microporosity for enantioselective α-amination of 3-aryl-2-oxindoles in batch and flow conditions

Martin, L. et al.; Org. Biomol. Chem., 2020, 18, 9275-9283

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Biocatalyzed Flow Oxidation of Tyrosol to Hydroxytyrosol and Efficient Production of Their Acetate Esters

Annunziata, F. et al.; Antioxidants, 2021, 10(7), 1142

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Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B

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Biorefinery via Achmatowicz Rearrangement: Synthesis of Pentane-1,2,5-triol from Furfuryl Alcohol

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Bis(diethylamino)(pentafluorophenyl)phosphane – a push–pull phosphane available for coordination

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Boosting the Performance of Nano-Ni Catalysts by Palladium Doping in Flow Hydrogenation of Sulcatone

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Boosting the Productivity of H2-Driven Biocatalysis in a Commercial Hydrogenation Flow Reactor Using H2 From Water Electrolysis

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Build−Couple−Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity

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Building β-peptide H10/12 foldamer helices with six-membered cyclic side-chains: Fine-tuning of folding and self-assembly

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C-N Bond Formation by Consecutive Continuous-Flow Reductions towards A Medicinally Relevant Piperazine Derivative

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Can two‐dimensional gas chromatography/mass spectrometric identification of bicyclic aromatic acids in petroleum fractions help to reveal further details of aromatic hydrocarbon biotransformation pathways?

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Catalysis in flow: Au-catalysed alkylation of amines by alcohols

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Catalytic asymmetric crotylation of aldehydes: Application in total synthesis of (−)‐elisabethadione

O’Hora, P. S.; Incerti‐Pradillos, C. A.; Kabeshov, M. A.; Shipilovskikh, S. A.; Rubtsov, A. E.; Elsegood, M. R. J; Malkov, A. V.; Chem. Eur. J., 2015, 21(12), 4551-4555

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Catalytic epoxidation of cyclohexene with tert-butylhydroperoxide using an immobilized molybdenum catalyst

Morales-delaRosa, S.; Campos-Martin, J. M.; Terreros, P.; Fierro, J. L. G.; Topics in Catalysis, 2015, 58, 325-333

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Catalytic Hydrogenation of Nitrocyclohexane with CuCo/SiO2 Catalysts in Gas and Liquid Flow Reactors

Kowalewski, E. et al.; Catalysts, 2022, 12(9), 1062

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Catalytic hydrogenolysis of substituted diaryl ethers by using ruthenium nanoparticles on an acidic supported ionic liquid phase (Ru@SILP-SO3H)

Rengshausen, S.; Etscheidt, F.; Großkurth, J.; Luska, K. L.; Bordet, A.; Leitner, W.; Synlett, 2019, 30(4), 405-412

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Catalytic oxidation of aqueous bioethanol: an efficient upgrade from batch to flow

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Catalytically sustainable, palladium-decorated graphene oxide monoliths for synthesis in flow

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Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

Gallagher, C. M.; Garri, C.; Cain, E. L.; Ang, K. K. H.; Wilson, C. G.; Chen, S.; Hearn, B. R.; Jaishankar, P.; Aranda-Diaz, A.; Arkin, M. R.; Renslo, A. R.; Walter, P.; eLife, 2016, 5, e:11878

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Chalcone Derivatives: Promising Starting Points for Drug Design

Gomes, M. N. et al.; Molecules, 2017, 22, 1210

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Characterization of dispersion effects on reaction optimization and scale-up for a packed bed flow hydrogenation reactor

Eschelbach, J. W.; Wernick, D.; Bryan, M. C.; Doherty, E. M.; Aust. J. Chem., 2013, 66, 165-171

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Chemical and bacterial reduction of azo-probes: monitoring a conformational change using fluorescence spectroscopy

Rattray, N. J. W.; Zalloum, W. A.; Mansell, D.; Latimer, J.; Jaffar, M.; Bichenkova, E. V.; Freeman, S.; Tetrahedron, 2013, 69, 2758-2766

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Chemical assembly systems: Layered control for divergent, continuous, multistep syntheses of active pharmaceutical ingredients

Ghislieri, D.; Gilmore, K.; Seeberger, P. H.; Angew. Chem. Int. Ed., 2014, 54(2), 678-682

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Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

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Chemical synthesis of β-D-ManNAc containing pentasaccharide repeating unit of the exopolysaccharide from Lactobacillus rhamnosus BIM B-1039 in the form of its p-methoxyphenyl glycoside

Bera, A. et al.; Carbohydrate Research, 2022, 522, 108708

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Chemical Synthesis of β‑L‑Rhamnose Containing the Pentasaccharide Repeating Unit of the O‑Specific Polysaccharide from a Halophilic Bacterium Halomonas ventosae RU5S2EL in the Form of Its 2‑Aminoethyl Glycoside

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Chemical synthesis of a tetrasaccharide related to the exocellular polysaccharide from Rhodococcus sp. RHA1

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Chemical synthesis of the 4-amino-4,6-dideoxy-d-glucose containing pentasaccharide repeating unit of the O-specific polysaccharide from Aeromonas hydrophila strain K691 in the form of its 2-aminoethyl glycoside

Adak, A.; Mukhopadhyay, B.; Carbohydrate Research, 2019, 476, 1-7

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Chemical synthesis of the pentasaccharide related to the repeating unit of the O-Antigen from Salmonella enterica O4

Das, R.; Mukhopadhyay, B.; Journal of Carbohydrate Chemistry, 2015, 34(5), 247-262

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Chemical synthesis of the pentasaccharide repeating unit of the O-specific polysaccharide from Escherichia coli O132 in the form of its 2-aminoethyl glycoside

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Chemical synthesis of the pentasaccharide repeating unit of the O-specific polysaccharide from Ruminococcus gnavus

Pal, D. et al.; Carbohydrate Research, 2021, 507, 108384

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Chemical synthesis of the rare D-Fuc3NAc containing tetrasaccharide repeating unit of the O-antigenic polysaccharide from E. coli O74

Bera, A. et al.; Carbohydrate Research, 2021, 506, 108366

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Chemical synthesis of the tetrasaccharide repeating unit of the O-polysaccharide isolated from Azospirillum brasilense SR80

Sarkar, V. et al.; Carbohydrate Research, 2015, 406, 65-70

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Chemistry of 3-carbonyl-2-methyl-4-oxo-4H-1-benzopyrans

Ghosh, C. K.; Chakraborty, A.; ARKIVOC, 2016, 2016(1), 111-149

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Chemistry of pyrrolizidine alkaloids revisited – semi-synthetic microwave and continuous-flow approaches toward Crotalaria-alkaloids

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Chemo-Catalyzed Pathways to Lactic Acid and Lactates

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Chemo-enzymatic synthesis of 13C labeled complex N-glycans as internal standards for the absolute glycan quantification by mass spectrometry

Echeverria, B.; Etxebarria, J.; Ruiz, N.; Hernandez, A.; Calvo, J.; Haberger, M.; Reusch, D.; Reichardt, N-C.; Analytical Chemistry, 2015, 87(22), 11460-11467

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Chemoenzymatic Synthesis in Flow Reactors: A Rapid and Convenient Preparation of Captopril

De Vitis, V. et al.; ChemistryOpen, 2017, 6, 668-673

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Chemoselective Continuous-Flow Hydrogenation of Aldehydes Catalyzed by Platinum Nanoparticles Dispersed in an Amphiphilic Resin

Osako, T. et al.; ACS Catal., 2017, 7, 7371-7377

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Chemoselective flow hydrogenation approaches to diversify the cytotoxic tetrahydroepoxyisoindole carboxamide scaffold

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Chemoselective flow hydrogenation approaches to isoindole-7-carboxylic acids and 7-oxa-bicyclio[2.2.1]heptanes

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Chemoselective flow hydrogenation of α,β – Unsaturated aldehyde with nano-nickel

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Chemoselective three-phase hydrogenation of an Ombrabulin nitro-stilbene intermediate in a continuous-flow mobile platform

Rehm, T. H. et al.; Chemical Engineering Journal, 2017, 316, 1069-1077

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Chiral auxiliary recycling in continuous flow: automated recovery and reuse of Oppolzer’s sultam

Sullivan, R. J.; Newman, S. G.; Chemical Science, 2018, 9, 2130-2134

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Chitin-Derived Nanocatalysts for Reductive Amination Reactions

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CIS is a potent checkpoint in NK cell–mediated tumor immunity

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Click 1,2,3-triazole derived fluorescent scaffold by mesoionic carbene–nitrene cyclization: an experimental and theoretical study

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Co Loading Adjustment for the Effective Obtention of a Sedative Drug Precursor through Efficient Continuous-Flow Chemoselective Hydrogenation of 2-Methyl-2-Pentenal

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Cobalt-doped magnesium fluoride as a support for platinum catalysts: The correlation of surface acidity with hydrogenation activity

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Combining enabling techniques in organic synthesis: continuous flow process with heterogenized catalysts

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Combining microfluidics and FT-IR spectroscopy: towards spatially resolved information on chemical processes

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Comparative Study of Supported Monometallic Catalysts in the Liquid-Phase Hydrogenation of Furfural: Batch Versus Continuous Flow

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Comparative study on the liquid chromatographic enantioseparation of cyclic β‐amino acids and the related cyclic β‐aminohydroxamic acids on Cinchona alkaloid‐based zwitterionic chiral stationary phases

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Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling

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Concise synthesis of a tetra- and a trisaccharide related to the repeating unit of the O-antigen from Providencia rustigianii O34 in the form of their p-methoxyphenyl glycosides

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Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxidation

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Concise synthesis of the tetrasaccharide repeating unit of the O-antigen from Escherichia coli O131 containing N-acetyl neuraminic acid

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Concise synthesis of the trisaccharide repeating unit of the O-polysaccharide from Aeromonas hydrophila A19 (O:14)

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Concise synthesis of vesnarinone and its analogues by using Pd‐catalyzed C–N bond‐forming reactions

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Construction and validation of an automated flow hydrogenation instrument for application in high-throughput organic chemistry

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Construction of a bicyclic β-benzyloxy and β-hydroxy amide library through a multicomponent cyclization reaction

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Continuous 2-Methyl-3-butyn-2-ol Selective Hydrogenation on Pd/γ-Al2O3 as a Green Pathway of Vitamin A Precursor Synthesis

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Continuous enzymatic stirred tank reactor cascade with unconventional medium yielding high concentrations of (S)-2-hydroxyphenyl propanone and its derivatives

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Continuous flow alcoholysis of furfuryl alcohol to alkyl levulinates using zeolites

Zhao, D.; Prinsen, P.; Wang, Y.; Ouyang, W.; Delbecq, F.; Len, C.; Luque, R.; ACS Sustainable Chem. Eng., 2018, 6(5), 6901-6909

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Continuous flow biocatalysis

Britton, J.; Majumdar, S.; Weiss, G. A.; Chem. Soc. Rev., 2018, 47, 5891-5918

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Continuous-flow biochemical reactors: Biocatalysis, bioconversion, and bioanalytical applications utilizing immobilized microfluidic enzyme reactors

Hajba, L.; Guttman, A.; J. Flow Chem., 2016, 6(1), 8-12

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Continuous-flow catalytic deuterodehalogenation carried out in propylene carbonate

Mandity, I. M.; Fulop, F.; Orsy, G.; Green Chemistry, 2019, 21, 956-961

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Continuous-flow catalytic hydrogenation of 3a,6-epoxyisoindoles

Zaytsev, V. P.; Zubkov, F. I.; Mertsalov, D. F.; Orlova, D. N.; Sorokina, E. A.; Nikitina, E. V.; Varlamov, A. V.; Russian Chemical Bulletin, 2015, 64, 112-126

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Continuous flow conversion of alkyl levulinates into γ-valerolactone in the presence of Ru/C as catalyst

Zhao, D.; Wang, Y.; Delbecq, F.; Len, C.; Molecular Catalysis, 2019, 475, 110456

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Continuous flow conversion of biomass-derived methyl levulinate into γ-valerolactone using functional metal organic frameworks

Ouyang, W.; Zhao, D.; Wang, Y.; Balu, A. M.; Len, C.; Luque, R.; ACS Sustainable Chem. Eng., 2018, 6(5), 6746-6752

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Continuous-flow enzymatic resolution strategy for the acylation of amino alcohols with a remote stereogenic centre: synthesis of calycotomine enantiomers

Schonstein, L.; Forro, E.; Fulop, F.; Tetrahedron: Asymmetry, 2013, 24, 202-206

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Continuous flow fabrication of block copolymer–grafted silica micro‐particles in environmentally friendly water/ethanol media

Ye, P.; Cao, P-F.; Chen, Q.; Advincula, R.; Macromol. Mater. Eng., 2018, 1800451

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Continuous-flow high pressure hydrogenation reactor for optimization and high-throughput synthesis

Jones, R. V.; Godorhazy, L.; Varga, N.; Szalay, D.; Urge, L.; Darvas, F.; J. Comb. Chem., 2006, 8(1), 110-116

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Continuous-Flow Hydrogenation of 4-Phenylpyridine to 4-Phenylpiperidine with Integrated Product Isolation Using a CO2 Switchable System

Barwinski, B. et al.; J. Flow Chem., 2017, 7(2), 41-45

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Continuous-flow hydrogenation of D-xylose with bimetallic ruthenium catalysts on micrometric alumina

Paun, C.; Lewin, E.; Sa, J.; iMedPub., 2017

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Continuous flow hydrogenation of functionalized pyridines

Irfan, M.; Petricci, E.; Glasnov, T. N.; Taddei, M.; Kappe, C. O.; Eur. J. Org. Chem., 2009, 9, 1327-1334

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Continuous flow hydrogenation of nitroarenes, azides and alkenes using maghemite-Pd nanocomposites

Rathi, A. K. et al.; Catal. Sci. Technol., 2016, 6, 152-160

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Continuous-flow hydrogenation of nitrocyclohexane toward value-added products with CuZnAl hydrotalcite derived materials

Kowalewski, E. et al.; Applied Catalysis A, General, 2021, 618, 118134

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Continuous-flow hydrogenation of olefins and nitrobenzenes catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

Osako, T.; Torii, K.; Tazawa, A.; Uozumi, Y.; RSC Adv., 2015, 5, 45760-45766

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Continuous flow hydrogenation with Pd complexes of pyridine-benzotriazole ligands

Yilmaz, F. et al.; Appl. Organomet. Chem., 2021, 35(11), e6389

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Continuous flow (micro-)reactors for heterogeneously catalyzed reactions: Main design and modelling issues

Rossetti, I.; Catalysis Today, 2018, 308, 20-31

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Continuous-flow microreactor chemistry under high-temperature/pressure conditions

Razzaq, T.; Glasnov, T. N.; Kappe, C. O.; Eur. J. Org. Chem., 2009, 9, 1321-1325

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Continuous flow multi-step organic synthesis

Webb, D.; Jamison, T. F.; Chemical Science, 2010, 6, 675-680

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Continuous flow nanocatalysis: reaction pathways in the conversion of levulinic acid to valuable chemicals

Bermudez, J. M.; Menendez, J. A.; Romero, A. A.; Serrano, E.; Garcia-Martinez, J.; Luque, R.; Green Chem., 2013, 15(10), 2786-2792

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Continuous flow organic chemistry: successes and pitfalls at the interface with current societal challenges

Gerardy, R.; Emmanuel, N.; Toupy, T.; Kassin, V-E.; Tshibalonza, N. N.; Schmitz, M.; Monbaliu, J-C. M.; Eur. J. Org. Chem., 2018, 2018(20-21), 2301-2351

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Continuous-flow organic synthesis: a tool for the modern medicinal chemist

Wiles, C.; Watts, P.; Future Med. Chem., 2009, 1(9), 1593-1612

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Continuous flow organic synthesis under high-temperature/pressure conditions

Razzaq, T.; Kappe, C. O.; Chem. Asian J., 2010, 5(6), 1274-1289

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Continuous flow ozonolysis in a laboratory scale reactor

Irfan, M.; Glasnov, T. N.; Kappe, C. O.; Organic Letters, 2011, 13(5), 984-987

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Continuous-flow Pd-catalyzed carbonylation of aryl chlorides with carbon monoxide at elevated temperature and pressure

Mata, A.; Hone, C. A.; Gutmann, B.; Moens, L.; Kappe, C. O.; ChemCatChem, 2018, 11(3), 997-1001

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Continuous flow process development for the synthesis of an industrial raw material via solvent-free aromatic Claisen rearrangement

Petrovic, N. et al.; J. Flow Chem., 2023, DOI: 10.1007/s41981-023-00275-z

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Continuous-flow processes for the catalytic partial hydrogenation reaction of alkynes

Moreno-Marrodan, C. et al.; Beilstein J. Org. Chem., 2017, 13, 734-754

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Continuous-flow processes in heterogeneously catalyzed transformations of biomass derivatives into fuels and chemicals

Serrano-Ruiz, J. C.; Luque, R.; Campelo, J. M.; Romero, A. A.; Challenges, 2012, 3, 114-132

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Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients

de Souza, R. O. M. A.; Aguiar, R.; Leao, R. A. C.; Miranda, L. S. N.; Kappe, C. O.; Cantillo, D.; Mata, A.; Org. Biomol. Chem., 2019, 17, 1552-1557

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Continuous flow reactors: a perspective

Wiles, C.; Watts, P.; Green Chem., 2012, 14, 38-54

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Continuous flow Reductive Alkylation of Methanol by Aldehydes. Synthesis of O-Methyl Ethers and 1,1-Dimethoxyacetals

Radjagobalou, R. et al.; Mol. Cat., 2022, 524, 112321

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Continuous-flow reductive alkylation: synthesis of bio-based symmetrical and disymmetrical ethers

Bruniaux, S.; Luart, D.; Len, C.; Synthesis, 2018, 50, 1849-1856

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Continuous-flow reductive etherification of furfural over CuAlOx catalyst combined with HZSM-5-Al2O3 composite

Nuzhdin, A. L. et al.; Fuel, 2024, 356, 129622

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Continuous Flow retro-Diels-Alder Reaction: A Novel Process Window for Designing New Heterocyclic Scaffolds

Nekkaa, I. et al.; Eur. J. Org. Chem., 2018, 2018(32), 4456-4464

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Continuous flow room temperature reductive aqueous homo-coupling of aryl halides using supported Pd catalysts

Feiz, A.; Bazgir, A.; Balu, A. M.; Luque, R.; Sci. Rep., 2016, 6, Article number: 32719

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Continuous flow selective hydrogenation of 5-hydroxymethylfurfural to 2,5-dimethylfuran using highly active and stable Cu-Pd/reduced graphene oxide

Mhadmhan, S.; Franco, A.; Pineda, A.; Reubroycharoen, P.; Luque, R.; ACS Sustainable Chem. Eng., 2019, 7(16), 14210-14216

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Continuous-flow stereoselective reduction of prochiral ketones in a whole cell bioreactor with natural deep eutectic solvents

Annunziata, F. et al.; Green Chemistry, 2022, 24, 950

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Continuous flow study of isoeugenol to vanillin: A bio-based iron oxide catalyst

Filiciotto, L. et al.; Catalysis Today, 2021, 368, 281-90

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Continuous-flow syntheses of heterocycles

Glasnov, T. N.; Kappe, C. O.; J. Heterocyclic Chem., 2011, 48, 11-30

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Continuous flow synthesis. A pharma perspective

Malet-Sanz, L.; Susanne, F.; J. Med. Chem., 2012, 55(9), 4062-4098

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Continuous flow synthesis of 6-monoamino-6-monodeoxy-β-cyclodextrin

Orosz, J. M. et al.; Beilstein J. Org. Chem., 2023, 19, 294-302

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Continuous Flow Synthesis of a Key 1,4-Benzoxazinone Intermediate via a Nitration/Hydrogenation/Cyclization Sequence

Cantillo, D. et al.; Org. Process Res. Dev., 2017, 21, 125-132

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Continuous flow synthesis of amines from the cascade reactions of nitriles and carbonyl-containing compounds promoted by Pt-modified titania catalysts

Altug, C. et al.; Green Chemistry, 2019, 21, 300-306

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Continuous-Flow Synthesis of Cyclobutenes Using LED Technology

Smyth, M. et al.; Synlett, 2023, DOI: 10.1055/a-2086-0630

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Contiuous-flow synthesis of deuterium-labeled antidiabetic chalcones: studies towards the selective deuteration of the alkynone core

Otvos, S. B.; Hsieh, C. T.; Wu, Y. C.; Li, J. H.; Chang, F. R.; Fulop, F.; Molecules, 2016, 21(3), 318-329

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Continuous Flow Synthesis of High Valuable N-Heterocycles via Catalytic Conversion of Levulinic Acid

Rodriguez-Padron, D. et al.; Front. Chem., 2019, 7, 103

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Continuous flow synthesis of menthol via tandem cyclisation-hydrogenation of citronellal catalysed by scrap catalytic converters

Zuliani, A.; Cova, C. M.; Manno, R.; Sebastian, V.; Romero, A. A.; Luque, R.; Green Chemistry, 2020, 22, 379-387

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Continuous-flow synthesis of primary amines: Metal-free reduction of aliphatic and aromatic nitro derivatives with trichlorosilane

Porta, R. et al.; Beilstein J. Org. Chem., 2016, 12, 2614-2619

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Continuous-flow synthesis of thermochromic M-Phase VO2 particles via rapid one-step hydrothermal reaction: Effect of mixers

Yan, X. et al.; Journal of Nanomaterials, 2019, 2019, 2570698

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Continuous flow transfer hydrogenation of biomass derived methyl levulinate over Zr containing zeolites: Insights into the role of the catalyst acidity

Cabanillas, M.; Franco, A.; Lazaro, N.; Balu, A. M.; Luque, R.; Pineda, A.; Mol. Cat., 2019, 477, 110522

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Continuous reductive amination of biomass-derived molecules over carbonized filter paper-supported FeNi alloy

Chieffi, G.; Braun, M.; Esposito, D.; ChemSusChem, 2015, 8(21), 3590-3594

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Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography

Orkenyi, R. et al.; Angew. Chem. Int. Ed., 2017, 129, 8868-8871

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Continuous‐flow hydrogenation and reductive deuteration of nitriles: a simple access to α,α‐dideutero amines

Meszaros, R.; Peng, B.; Otvos, S. B.; Yang, S.; Fulop F.; ChemPlusChem, 2019, 84(10), 1508-1511

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Continuous‑flow hydrogenation over resin supported palladium catalyst for the synthesis of industrially relevant chemicals

Kowalewski, E. et al.; Reaction Kinetics, Mechanisms and Catalysis, 2021, 132, 717-728

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Controlled photo-flow oxidative reaction (UV-FOR) platform for ultra-fast phthalides and API synthesis

Aand, D. et al.; Green Chemistry, 2018, 20, 4584-4590

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Convergent synthesis of the hexasaccharide related to the repeating unit of the O-antigen from E. coli O120

Budhadev, D.; Mukhopadhyay, B.; RSC Adv., 2015, 5, 98033-98040

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Convergent synthesis of the hexasaccharide repeating unit of the O-antigenic OPS of Escherichia coli O133

Mitra, A.; Mukhopadhyay, B.; Eur. J. Org. Chem., 2019, 2019(30), 4869-4878

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Copper-catalyzed rearragement of oximes into primary amides

Sharma, S. K.; Bishopp, S. D.; Allen, C. L.; Lawrence, R.; Bamford, M. J.; Lapkin, A. A.; Plucinski, P.; Watson, R. J.; Williams, J. M .J.; Tetrahedron Letters, 2011, 52, 4252-4255

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Copper-zinc oxide interface as a methanol-selective structure in Cu-ZnO catalyst during catalytic hydrogenation of carbon dioxide to methanol

Saedy, S. et al.; Catal. Sci. Technol., 2022, 12, 2703-2716

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Covalently immobilized Trp60Cys mutant of ω-transaminase from Chromobacterium violaceum for kinetic resolution of racemic amines in batch and continuous-flow modes

Abahazi, E.; Satorhelyi, P.; Erdelyi, B.; Vertessy, B. G.; Land, H.; Paizs, C.; Berglund, P.; Poppe, L.; Biochem. Eng. J., 2018, 132, 270-278

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Cross-coupling in flow

Noel, T.; Buchwald, S. L.; Chem. Soc. Rev., 2011, 40, 5010-5029

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Cu-Al mixed oxide derived from layered double hydroxide as an efficient catalyst for continuous-flow reductive amination of aromatic aldehydes

Nuzhdin, A. L. et al.; J. Chem. Technol. Biotechn., 2020, 95, 3292-3299

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Cubanes in medicinal chemistry: Synthesis of functionalized building blocks

Wlochal, J.; Davies, R. D. M.; Burton, J.; Org. Lett., 2014, 16, 4094-4097

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Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine

Bashore, C. et al.; ACS Chem. Biol., 2020, 15(6), 1392-1400

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De novo design of a picomolar nonbasic 5-HT1B receptor antagonist

Nugiel, D. A.; Krumrine, J. R.; Hill, D. C.; Damewood, J. R.; Bernstein, P. R.; Sobotka-Briner, C. D.; Liu, J. W.; Zacco, A.; Pierson, M. E.; J. Med. Chem., 2010, 53, 1876-1880

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De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments

Urich, R.; Wishart, G.; Kiczun, M.; Richters, A.; Tidten-Luksch, N.; Rauh, D.; Sherborne, B.; Wyatt, P. G.; Brenk, R.; ACS Chem. Biol., 2013, 8(5), 1044-1052

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De novo design, synthesis and pharmacological evaluation of new azaindole derivatives as dual inhibitors of Abl and Src kinases

Cheve, G.; Bories, C.; Fauvel, B.; Picot, F.; Tible, A.; Dayde-Cazals, B.; Loget, O.; Yasri, A.; Med. Chem. Commun., 2012, 3, 788-800

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Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens

Kenfack, M. T. et al.; Nature Communications, 2017, 8, 115

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Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

Pallesen, J. S. et al.; J. Med. Chem., 2021, 64(8), 4623-4661

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Densely substituted L-proline esters as catalysts for asymmetric Michael additions of ketones to nitroalkenes

Ruiz-Olalla, A.; de Gracia Retamosa, M.; Cossio, F. P.; J. Org. Chem., 2015, 80(11), 5588-5599

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Dependence of the Properties of Fluorine-Containing Poly(phenylquinoxaline) on the Method of Its Preparation

Bulycheva, E. G. et al.; Doklady Chemistry, 2017, 475, 159-163

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Design and development of Pd-catalyzed aerobic N-demethylation strategies for the synthesis of noroxymorphone in continuous flow mode

Gutmann, B.; Cantillo, D.; Weigl, U.; Cox, P.; Kappe, C. O.; Eur. J. Org. Chem., 2017, 914-927

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Design and development of photoswitchable DFG-Out RET kinase inhibitors

Grotli, M. et al.; Eur. J. Med. Chem., 2022, 234, 114226

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Design and Scaling Up of Microchemical Systems: A Review

Zhang, J. et al.; Ann. Rev. Chem. Biomol. Eng., 2017, 8, 285-305

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Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins

Preston, A. et al.; J. Med. Chem., 2023, 63(17), 9070–9092

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Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist

Clarke, E.; Jarvis, C. I.; Goncalves, M. B.; Kalindjian, S. B.; Adams, D. R.; Brown, J. T.; Shiers, J. J.; Taddei, D. M. A.; Ravier, E.; Barlow, S.; Miller, I., Smith, V.; Borthwick, A. D.; Corcoran, J. P. T.; Bioorg. Med. Chem., 2018, 26(4), 798-814

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Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119

Darout, E.; Robinson, R. P.; McClure, K. F.; Corbett, M.; Li, B.; Shavnya, A.; Andrews, M. P.; Jones, C. S.; Li, Q.; Minich, L. M.; Mascitti, V.; Guimaraes, C. R. W.; Munchhof, M. J.; Bahnck, K. B.; Cai, C.; Price, D. A.; Liras, S.; Bonin, P. D.; Cornelius, P.; Wang, R.; Bagdasarian, V.; Sobota, C. P.; Hornby, S.; Masterson, V. M.; Joseph, R. M.; Kalgutkar, A. S.; Chen, Y.; J. Med. Chem., 2013, 56, 301-319

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Design and synthesis of multivalent α-1,2-trimannose-linked bioerodible microparticles for applications in immune response studies of Leishmania major infection

Rintelmann, C. R.; Grinnage-Pulley, T.; Ross, K.; Kabotso, D. E. K.; Toepp, A.; Cowell, A.; Petersen, C.; Narasimhan, B.; Pohl, N.; Beilstein J. Org. Chem., 2019, 15, 623-632

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Design of a highly selective and potent class of non-planar estrogen receptor ß agonists

Sunden, H.; Ma, J. N.; Hansen, L. K.; Gustavsson, A. L.; Burstein, E. S.; Olsson, R.; ChemMedChem, 2013, 8(8), 1283-1294

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Design of experiments (DoE) and process optimization. A review of recent publications

Weissman, S. A.; Anderson, N. G.; Org. Process Res. Dev., 2015, 19(11), 1605-1633

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Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists

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Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis

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Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators

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Design, Synthesis, Structure–Activity Relationship Studies, and Three-Dimensional Quantitative Structure–Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase

De Simone, A. et al.; J. Med. Chem., 2017, 60, 2287-2304

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Deuterated Liquid Crystals – design and synthesis of deuterium labelled 4,4ʺ-dialkyl-2′,3′-difluoro-[1,1′:4′,1ʺ]terphenyls using batch and continuous flow systems

Zak, M. et al.; Liquid Crystals, 2022, https://doi.org/10.1080/02678292.2022.2145379

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Development of a Novel Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist (CH5447240), a Potent and Orally Available Small Molecule for Treatment of Hypoparathyroidism

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Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling

Marin-Ramos, N. I. et al.; Chem. Eur. J., 2017, 1676-1685

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Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Structure-Activity Relationship and Effects on Ether Lipids and Epithelial-Mesenchymal Transition in Cancer Cells

Stazi, G. et al.; Eur. J. Med. Chem., 2018, 163, 722-735

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Development of biolubricants from vegetable oils via chemical modification

McNutt, J.; He, Q.; J. Ind. Eng. Chem., 2016, 36, 1-12

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Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors

Lawrence, H. R.; Martin, M. P.; Luo, Y.; Pireddu, R.; Yang, H.; Gevariya, H.; Ozcan, S.; Zhu, J. Y.; Kendig, R.; Rodriguez, M.; Elias, R.; Cheng, J. Q.; Sebti, S. M.; Schonbrunn, E.; Lawrence, N. J.; J. Med. Chem., 2012, 55(17), 7392-7416

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Development of second-generation indole-based dynamin GTPase inhibitors

Gordon, C. P.; Venn-Brown, B.; Robertson, M. J.; Young, K. A.; Chau, N.; Mariana, A.; Whiting, A.; Chircop, M.; Robinson, P. J.; McCluskey, A.; J. Med. Chem., 2013, 56, 46-59

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Diacylglycerol synthesis by lipase-catalyzed partial hydrolysis of palm oil under microwave irradiation and continuous flow conditions

Matos, L. M. C.; Leal, I. C. R.; de Souza, R. O. M. A.; Journal of Molecular Catalysis B: Enzymatic, 2011, 72, 36-39

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Diamino Allose Phosphates: Novel, Potent, and Highly Stable Toll-like Receptor 4 Agonists

Khalaf, J. K. et al.; J. Med. Chem., 2023, Accepted manuscript

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Diastereoselective 1,3-dipolar cycloaddition of pyrylium ylides with chiral enamides

Tchabanenko, K.; Sloan, C.; Bunetel, Y.; Mullen, P.; Org. Bioorg. Chem., 2012, 10, 4215-4219

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Diastereoselective [2,3]-sigmatropic rearrangement of N-allyl ammonium ylides

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Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assembly

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Diastereoselective synthesis of cis-N-Boc-4-aminocyclohexanol with reductive ring opening method using continuous flow

Szabo, B.; Tamas, B.; Faigl, F.; Eles, J.; Greiner, I.; J. Flow Chem., 2019, 9(1), 13-17

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Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars

Bergeron-Brlek, M.; Meanwell, M.; Britton, R.; Nature Communications, 2015, 6, 6303

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Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

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Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase

Cummings, M. D.; Lin, T.; Hu, L.; Tahri, A.; McDowan, D.; Amssoms, K.; Last, S.; Devogelaere, B., Rouan, M.; Vijgen, L., Berke, J. M.; Dehertogh, P.; Fransen, E.; Cleiren, E.; van der Helm, L.; Fanning, G.; Nyanguile, O.; Simmen, K.; Remoortere, P. V.; Raboisson, P.; Vendeville, S., J. Med. Chem., 2014, 57(5), 1880-1892

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Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design

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Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2

Zak, M.; Mendonca, R.; Balazs, M.; Barrett, K.; Bergeron, P.; Blair, W. S.; Chang, C.; Deshmukh, G.; DeVoss, J.; Dragovich, P. S.; Eigenbrot, C.; Ghilardi, N.; Gibbons, P.; Gradl, S.; Hamman, C.; Hanan, E.; Harstad, E.; Hewitt, P. R.; Hurley, C. A.; Jin, T.; Johnson, A.; Johnson, T.; Kenny, J. R.; Koehler, M. F. T.; Kohli, P. B.; Kulagowski, J.; Labadie, S.; Liao, J.; Liimatta, M.; Lin, Z.; Lupardus, P. J.; Maxey, R. J.; Murray, J. M.; Pulk, R.; Rodriguez, M.; Savage, S.; Shia, S.; Steffek, M.; Ubhayakar, S.; Ultsch, M.; Van-Abbema, A.; Ward, S.; Xiao, L.; Xiao, Y.; J. Med. Chem., 2012, 55(13), 6176-6193

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Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization

Cerqua, I. et al.; J. Med. Chem., 2022, 65(21), 14456-14480

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Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

Phillipson, L. J.; Segal, D. H.; Nero, T. L.; Parker, M. W.; Wan, S. S.; de Silva, M.; Guthridge, M. A.; Wei, A. H.; Burns, C. J.; Bioorg. Med. Chem., 2015, 23(19), 6280-6296

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Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)

Martin-Martin, M. L.; Bartolome-Nebreda, J. M.; Conde-Ceide, S.; Alonso de Diego, S. A.; Lopez, S.; Martinez-Viturro, C. M.; Tong, H. M.; Lavreysen, H.; Macdonald, G. J.; Steckler, T.; Mackie, C.; Bridges, T. M.; Daniels, J. S.; Niswender, C. M.; Noetzel, M. J.; Jones, C. K.; Conn, P. J.; Lindsley, C. W.; Stauffer, S. R.; Bioorg. Med. Chem. Lett., 2015, 25(6), 1310-1317

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Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors

Ge, Y.; Kazi, A.; Marsilio, F.; Luo, Y.; Jain. S.; Brooks, W.; Daniel, K. G.; Guida, W. C.; Sebti, S. M.; Lawrence, H. R.; J. Med. Chem., 2012, 55(5), 1978-1998

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Discovery of 14-3-3 PPI Stabilizers by Extension of an Amidine-Substituted Thiophene Fragment

Wu, Q. et al.; ChemBioChem, 2023, e202300636

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Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation

Giordanetto, F.; Wallberg, A.; Cassel, J.; Ghosal, S.; Kossenjans, M.; Yuan, Z. Q.; Wang, X.; Liang, L.; Bioorg. Med. Chem. Lett., 2012, 22, 6665-6670

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Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)

Axten, J. M.; Medina, J. R.; Feng, Y.; Shu, A.; Romeril, S. P.; Grant, S. W.; Li, W. H. H.; Heerding, D. A.; Minthorn, E.; Mencken, T.; Atkins, C.; Liu, Q.; Rabindran, S.; Kumar, R.; Hong, X.; Goetz, A.; Stanley, T.; Taylor, J. D.; Sigethy, S. D.; Tomberlin, G. H.; Hassell, A. M.; Kahler, K. M.; Shewchuk, L. M.; Gampe, R. T.; J. Med. Chem., 2012, 55(16), 7193-7207

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Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease

Leonard, K. A. et al.; J. Med. Chem., 2020, 63(6), 2915-2929

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Discovery of a new class of highly potent inhibitors of acid ceramidase: Synthesis and structure–activity relationship (SAR)

Pizzirani, D.; Pagliuca, C.; Realini, N.; Branduardi, D.; Bottegoni, G.; Mor, M.; Bertozzi, F.; Scarpelli, R.; Piomelli, D.; Bandiera, T.; J. Med. Chem., 2013, 56(9), 3518-3530

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Discovery of a novel chemotype of histone lysine methyltransferase EHMT1/2 (GLP/G9a) inhibitors: rational design, synthesis, biological evaluation and cocrystal structure

Milite, C.; Feoli, A.; Horton, J. R.; Rescigno, D.; Cipriano, A.; Pisapia, V.; Viviano, M.; Pepe, G.; Amendola, G.; Novellino, E.; Cosconati, S.; Cheng, X.; Castellano, S.; Sbardella, G.; J. Med. Chem., 2019, 62(5), 2666-2689

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Discovery of a novel inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) as orally active antitumor agent

Vianello, P.; Botrugno, O. A.; Cappa, A.; Zuffo, R. D.; Dessanti, P.; Mai, A.; Marrocco, B.; Mattevi, A.; Meroni, G.; Minucci, S.; Stazi, G.; Thaler, F.; Trifiro, P.; Valente, S.; Villa, M.; Mercurio, C.; J. Med. Chem., 2016, 59(4), 1501-1517

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Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists

Scott, J. S. et al.; J. Med. Chem., 2023, 66(4), 2918-2945

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Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe

Bamborough, P. et al.; J. Med. Chem., 2017, 60, 695-709

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Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours

Barlaam, B.; Cosulich, S.; Degorce, S.; Ellston, R.; Fitzek, M.; Green, S.; Hancox, U.; Lambert-van der Brempt, C.; Lohmann, J-J.; Maudet, M.; Morgentin, M.; Ple, P.; Ward, L.; Warin, N.; Bioorg. Med. Chem. Lett., 2017, 27(9), 1949-1954

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Discovery of acrylonitrile-based small molecules active against Haemonchus contortus

Gordon, C. P.; Hizartzidis, L.; Tarleton, M.; Sakoff, J. A.; Gilbert, J.; Campbell, B. E.; Gasser, R. B.; McCluskey, A.; Med. Chem. Commun., 2014, 5, 159-164

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Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models

Patel, S.; Cohen, F.; Dean, B. J.; De La Torre, K.; Deshmukh, G.; Estrada, A. A.; Ghosh, A. S.; Gibbons, P.; Gustafson, A.; Huestis, M. P.; Le Pichon, C. E.; Lin, H.; Liu, W.; Liu, X.; Liu, Y.; Ly, C. Q.; Lyssikatos, J. P.; Ma, C.; Scearce-Levie, K.; Shin, Y. G.; Solanoy, H.; Stark, K. L.; Wang, J.; Wang, B:; Zhao, X.; Lewcock, J. W.; Siu, M.; J. Med. Chem., 2015, 58(1), 401-418

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Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases

Caldwell, R. D. et al.; J. Med. Chem., 2019, 62(17), 7643-7655

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Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor

Giordanetto, F.; Wallberg, A.; Knerr, L.; Selmi, N.; Ullah, V.; Thorstensson, F.; Lindelof, L.; Karlsson, S.; Nikitidis, G.; Llinas, A.; Wang, Q. D.; Lindqvist, A.; Hogberg, L.; Lindhardt, E.; Astrand, A.; Duker, G.; Bioorg. Med. Chem. Lett., 2013, 23(1), 119-124

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Discovery of narrow spectrum kinase inhibitors: New therapeutic agents for the treatment of COPD and steroid-resistant asthma

Onions, S. T.; Ito, K; Charron, C. E.; Brown, R. J.; Colucci, M.; Frickel, F.; Hardy, G.; Joly, K.; King-Underwood, J.; Kizawa, Y.; Knowles, I.; Murray, P. J.; Novak, A.; Rani, A.; Rapeport, G.; Smith, A.; Strong, P.; Taddei, D. M.; Williams, J. G.; J. Med. Chem., 2016, 59(5), 1727-1746

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Discovery of PET radiopharmaceuticals at the academia-industry interface

Bernard-Gauthier, V. et al.; Drug Discovery Today: Technologies, 2017, 25, 19-26

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Discovery of potent and selective inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) protein kinase as potential anticancer agents

Charrier, J. D.; Durrant, S. J.; Golec, J. M. C.; Kay, D. P., Knegtel, R. M. A.; MacCormick, S.; Mortimore, M.; O'Donnell, M. E.; Pinder, J. L.; Reaper, P. M.; Rutherford, A. P.; Wang, P. S. H.; Young, S. C.; Pollard, J. R.; J. Med. Chem., 2011, 54(7), 2320-2330

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Discovery of potent and selective reversible Bruton’s tyrosine kinase inhibitors

Qiu, H. et al.; Bioorg. Med. Chem., 2021, 40, 116163

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Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux

Rzasa, R. M.; Hu, E.; Rumfelt, S.; Chen, N.; Andrews, K. L.; Chmait, S.; Falsey, J. R.; Zhong, W.; Jones, A. D.; Porter, A.; Louie, S. W.; Zhao, X.; Treanor, J. J. S.; Allen, J. R.; Bioorg. Med. Chem. Lett., 2012, 22, 7371-7375

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Discovery of tertiary amine and indole derivatives as potent RORγt inverse agonists

Yang, T.; Liu, Q.; Cheng, Y.; Cai, W.; Ma, Y.; Yang, L.; Wu, Q.; Orband-Miller, L. A.; Zhou, L.; Xiang, Z.; Huxdorf, M.; Zhang, W.; Zhang, J.; Xiang-J-N.; Leung, S.; Qiu, Y.; Zhong, Z.; Elliott, J. D.; Lin, X.; Wang, Y.; ACS Med. Chem. Lett., 2014, 5(1), 65-68

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Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases

Alper, P. et al.; ACS Med. Chem. Lett., 2023, Accepted manuscript

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Dissection of complex molecular recognition interfaces

Hunter, C. A.; Misuraca, M. C.; Turega, S. M.; J. Am. Chem. Soc., 2011, 133(3), 582-594

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Disubstituted 1-aryl-4-aminopiperidine library synthesis using computational drug design and high-throughput batch and flow technologies

Bryan, M. C.; Hein, C. D.; Gao, H.; Xia, X.; Eastwood, H.; Bruenner, B. A.; Louie, S. W.; Doherty, E. M; ACS Comb. Sci., 2013, 15(9), 503-511

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Diversity-oriented synthesis of a library of star-shaped 2H-imidazolines

Yu, X.; Guttenberger, N.; Fuchs, E.; Peters, M.; Weber, H.; Breinbauer R.; ACS Comb. Sci., 2015, 17(11), 682-690

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Diversity-oriented synthesis of dibenzoazocines and dibenzoazepines via a microwave-assisted intramolecular A3-coupling reaction

Bariwal, J. B.; Ermolat'ev, D. S.; Glasnov, T. N.; Van Hecke, K.; Mehta, V. P.; Van Meervelt, L.; Kappe, C. O.; Van der Eycken, E. V.; Org. Lett., 2010, 12(12), 2774-2777

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Doping carbon networks with phosphorus for supporting Pd in catalyzing selective oxidation of benzyl alcohol

Guo, W.; Niu, S.; Ji, X.; Yu, W.; Lin, T-W.; Wu, Y.; Li, Y.; Shao, L.; J. Nanopart. Res.; 2018, 20:180

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Double carbonylation of iodobenzene in a microfluidics-based high throughput flow reactor

Balogh, J.; Kuik, A.; Urge, L.; Darvas, F.; Bakos, J.; Skoda-Foldes, R.; Journal of Molecular Catalysis A: Chemical, 2009, 302, 76-79

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Dynamic experiments in flow accelerate reaction network definition in a complex hydrogenation using catalytic static mixers

Martinuzzi, S. et al.; React. Chem. Eng., 2023, DOI: 10.1039/d3re00451a

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Easy access to Ni3N- and Ni-carbon nanocomposite catalysts

Clavel, G.; Molinari, V.; Kraupner, A.; Giordano, C.; Chem. Eur. J., 2014, 20(29), 9018-9023

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Eco-efficiency analysis for intensified production of an active pharmaceutical ingredient: a case study

Dencic, I.; Ott, D.; Kralisch, D.; Noel, T.; Meuldijk, J.; de Croon, M.; Hessel, V.; Laribi, Y.; Perrichon, P.; Org. Process Res. Dev., 2014, 18(11), 1326-1338

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Effect of Binding Linkers on the Efficiency and Metabolite Profile of Biomimetic Reactions Catalyzed by Immobilized Metalloporphyrin

Balogh, Gy. T. et al.; Metabolites, 2022, 12(12), 1269

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Effect of unimodality and bimodality of Pd nanoparticles on the catalytic activity of Pd/SiO2 in the removal of diclofenac from water

Kowalewski, E. et al.; Cat. Comm., 2020, 143, 106056

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Effects of Regioisomerism on the Antiproliferative Activity of Hydroxystearic Acids on Human Cancer Cell Lines

Boga, C. et al.; Molecules, 2022, 27, 2396

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Efficient and continuous furfural hydrogenation to furfuryl alcohol in a micropacked bed reactor

Duan, L. et al.; React. Chem. Eng., 2023, 8, 1719-1728

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Efficient and scalable synthesis of thiazole fused benzazepine as a D2 partial agonist

Xiong, H.; Wu, Y.; Lehr, S. G.; Blackwell, W.; Steelman, G.; Hulsizer, J.; Urbanek, R. A.; Tetrahedron Letters, 2012, 53(44), 5833-5836

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Efficient Chemo-Enzymatic Flow Synthesis of High Value Amides and Esters

Annunziata, F. et al.; Catalysts, 2020, 10(8), 939

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Efficient continuous-flow synthesis of novel 1,2,3-triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production

Otvos, S. B.; Georgiades, A.; Mandity, I. M.; Kiss, L.; Fulop, F.; Beilstein J. Org. Chem., 2013, 9, 1508-1516

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Efficient lipase-catalysed route for the kinetic resolution of salsolidine and its ß-carboline analogue

Kovacs, B. et al.; Tetrahedron: Asymmetry, 2017, 28, 1829-1833

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Efficient Ru-based scrap waste automotive converter catalysts for the continuous-flow selective hydrogenation of cinnamaldehyde

Cova, C. M. et al.; Green Chemistry, 2019, 21, 4712-4722

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Electrochemical Effects at Surfactant–Platinum Nanoparticle Interfaces Boost Catalytic Performance

Almora-Barrios, N. et al.; ChemCatChem, 2017, 9, 604-609

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Electrochemical Hydroxylation of Electron-Rich Arenes in Continuous Flow

Kooli, A et al.; Eur. J. Org. Chem., 2022, 20, e202200011

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Electrochemical phenylselenoetherification as a key step in the synthesis of (±)-curcumene ether

Stevanovic, D.; Pejovic, A.; Damljanovic, I. S.; Vukicevic, M. D.; Dobrikov, G.; Dimitrov, V.; Denic, M. S.; Radulovic, N. S.; Vukicevic, R. D.; Helvetica Chimica Acta, 2013, 96(6), 1103-1110

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Electrophile-induced dearomatizing spirocyclization of N-arylisonicotinamides: A route to spirocyclic piperidines

Arnott, G.; Brice, H.; Clayden, J.; Blaney, E.; Organic Letters, 2008, 10(14), 3089-3092

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Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4)

Day, J. P.; Lindsay, B.; Riddel, T.; Jiang, Z.; Allock, R. W.; Abraham, A.; Sookup, S.; Christian, F.; Bogum, J.; Martin, E. K.; Rae, R. L.; Anthony, D.; Rosair, G. M.; Houslay, D. M.; Huston, E.; Baillie, G. S.; Klussmann, E.; Houslay, M. D.; Adams, D. R.; J. Med. Chem., 2011, 54(9), 3331-3347

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Emerging trends in flow chemistry and applications to the pharmaceutical industry

Bogdan, A. R.; Dombrowski, A. W.; J. Med. Chem., 2019, 62(14), 6422-6468

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Enabling the scale-up of a key asymmetric hydrogenation step in the synthesis of an API using continuous flow solid-supported catalysis

Amara, Z.; Poliakoff, M.; Duque, R.; Geier, D.; Francio, G.; Gordon, C. M.; Meadows, R. E.; Woodward, R.; Leitner, W.; Org. Process Res. Dev., 2016, 20, 1321-1327

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Enantiodivergent synthesis of bis-spiropyrrolidines via sequential interrupted and completed (3+2) cycloadditions

Conde, E.; Rivilla, I.; Larumbe, A.; Cossio F. P.; J. Org. Chem., 2015, 80(23), 11755-11767

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Enantiomer selective acylation of racemic alcohols by lipases in continuous-flow bioreactors

Csajagi, Cs.; Szatzker, G.; Toke, E. R.; Urge, L.; Darvas, F.; Poppe, L.; Tetrahedron: Asymmetry, 2008, 19(2), 237-246

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Enantiomeric separation of bicyclo[2.2.2]octane‐based 2‐amino‐3‐carboxylic acids on macrocyclic glycopeptide chiral stationary phases

Pataj, Z.; Ilisz, I.; Grecso, N; Palko, M.; Fulop, F.; Armstrong, D. W.; Peter, A.; Chirality, 2014, 26, 200-208

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Enantioselective access to benzannulated spiroketals using a chiral sulfoxide auxiliary

Aitken, H. R. M.; Furkert, D. P.; Hubert, J. G.; Wood, J. M.; Brimble, M. A.; Org. Biomol. Chem., 2013, 11, 5147-5155

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Enantioselective hydrogenation of α,β-unsaturated carboxylic acids in fixed-bed reactor

Herman, B.; Szollosi, G.; Fulop F.; Bartok, M.; Applied Catalysis A: General, 2007, 331, 39-43

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Enantioselective hydrolysis of 3,4-disubstituted β-lactams. An efficient enzymatic method for the preparation of a key Taxol side-chain intermediate

Galla, Zs.; Beke, F.; Forro, E.; Fulop, F.; Journal of Molecular Catalysis B: Enzymatic, 2016, 123, 107-112

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Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary

Jones, A. L.; Liu, X.; Snyder, J. K.; Tetrahedron Letters, 2010, 51(7), 1091-1094

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Enantioselective synthesis of bicyclo[2.2.2]octenones using a copper-mediated oxidative dearomatization/[4+2] dimerization cascade

Dong, S.; Zhu, J.; Porco, J. A.; J. Am. Chem. Soc., 2008, 130(9), 2738-2739

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Enantioselective synthesis of (+)-Chamaecypanone C: A novel microtubule inhibitor

Dong, S.; Hamel, E.; Bai, R.; Covell, D. G.; Beutler, J. A.; Porco, J .A.; Angew. Chem. Int. Ed., 2009, 48(8), 1494-1497

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End functionalization of polyisoprene and polymyrcene obtained by anionic polymerization via one-pot ring-opening mono-addition of epoxides

Zhang, J. et al.; European Polymer Journal, 2023, 183, 111755

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endo-Hydroxamic Acid Monomers for the Assembly of a Suite of Non-native Dimeric Macrocyclic Siderophores Using Metal Templated Synthesis

Brown, C. J. M. et al.; Inorg. Chem., 2019, 58(20), 13591-13603

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Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction

Liu, Q.; Wu, K.; Cheng, Y.; Lu, L.; Xiao, E.; Zhang, Y.; Deng, Z.; Liu, T.; Metabolic Engineering, 2015, 28, 82-90

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Enhanced biocatalytic performance of bacterial laccase from Streptomyces sviceus: Application in the Michael addition sequence towards 3‐arylated 4‐oxochromanes

Suljic, S.; Mortzfeld, F. B.; Gunne, M.; Urlacher, V. B.; Pietruszka, J.; ChemCatChem, 2015, 7(8), 1380-1385

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Ensemble Design in Nickel Phosphide Catalysts for Alkyne Semi-Hydrogenation

Albani, D. et al.; ChemCatChem, 2018, 11(1), 457-464

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Environmentally friendly synthesis of indoline derivatives using flow-chemistry techniques

Orkenyi, R.; Beke, G.; Riethmuller, E.; Szakacs, Z.; Koti, J.; Faigl, F.; Eles, J.; Greiner, I.; Eur. J. Org. Chem., 2017, 6525-6532

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Enzymatic reactions for the preparation of homocalycotomine enantiomers

Schonstein, L.; Forro, E.; Fulop, F.; Tetrahedron: Asymmetry, 2013, 24, 1059-1062

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Enzymatic strategy for the resolution of new 1‐hydroxymethyl tetrahydro‐β‐carboline derivatives in batch and continuous‐flow systems

Megyesi, R.; Forro, E.; Fulop, F.; ChemistryOpen, 2016, 5(3), 254-260

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Enzymatic synthesis and protein adsorption properties of crystalline nanoribbons composed of cellulose oligomer derivatives with primary amino groups

Nohara, T. et al.; J. Biomat. Sci., Polymer Ed., 2017, 28, 925-938

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Epoxy resin monomers with reduced skin sensitizing potency

O'Boyle, N. M.; Niklasson, I. B.; Tehrani-Bagha, A. R.; Delaine, T.; Holmberg, K.; Luthman, K.; Karlberg, A. T.; Chem. Res. Toxicol., 2014, 27(6), 1002-1010

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Evaluating dynamic kinetic resolution strategies in the asymmetric hydrosilylation of cyclic ketimines

Jones, S.; Zhao, P.; Tetrahedron: Asymmetry, 2014, 25(3), 238-244

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Evaluating the Green Credentials of Flow Chemistry towards Industrial Applications

Baumann, M. et al.; Synthesis, 2021, 53(21), 3963-3976

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Evaluation and Screening of Spherical Pd/C for Use as a Catalyst in Pharmaceutical-Scale Continuous Hydrogenations

Fernandez-Puertas, E. et al.; Org. Process Res. Dev., 2020, 24(10), 2147-2156

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Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis

Bryan, M. C.; Wernick, D.; Hein, C. D.; Petersen, J. V.; Eschelbach, J. W.; Doherty, E. M.; Beilstein J. Org. Chem., 2011, 7, 1141-1149

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Evaluation of bifunctional chiral phosphine oxide catalysts for the asymmetric hydrosilylation of ketimines

Warner, C. J. A.; Berry, S. S.; Jones, S.; Tetrahedron, 2019, accepted manuscript

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Evaluation of functional groups as acetyl-lysine mimetics for BET bromodomain inhibition

Sharp, P. P.; Garnier, J-M.; Huang, D. C. S.; Burns, C. J.; MedChemCommun, 2014, 5, 1834-1842

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Evaluation of SILP-Pd catalysts for Heck reactions in amicrofluidics-based high throughput flow reactor

Urban, B.; Sranko, D.; Safran, G.; Urge, L.; Darvas, F.; Bakos, J.; Skoda-Foldes, R.; Journal of Molecular Catalysis A: Chemical, 2014, 395, 364-372

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Evaluation of Sponge Metal Catalysts in a Trickle Bed Reactor for the Continuous Hydrogenation of an Aliphatic Nitro Intermediate

Carangio, A. et al.; Org. Process Res. Dev., 2020, 24(10), 1909-1919

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Excellent antimicrobial and photocatalytic performance of C/GO/TiO2/Ag and C/TiO2/Ag hybrid nanocomposite beds against waterborne microorganisms

Jakubczak, M. et al.; Mat. Chem. Phys., 2023, 297, 127333

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Expanding the toolbox of asymmetric organocatalysis by continuous-flow process

Finelli, F. G.; Miranda, L. S. M.; de Souza, R. O. M. A.; Chem. Commun., 2015, 51, 3708-3722

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Expanding the utility of flow hydrogenation – a robust protocol restricting hydrodehalogenation

Hizartzidis, L.; Cossar, P. J.; Robertson, M. J.; Simone, M. I.; Young, K. A.; McCluskey, A.; Gordon, C. P.; RSC Adv., 2014, 4, 56743-56748

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Expedient Diels–Alder cycloadditions with ortho-quinodimethanes in a high temperature/pressure flow reactor

Tsoung, J.; Wang, Y.; Djuric, S. W.; React. Chem. Eng., 2017, 2, 458-461

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Exploiting the 4‑Phenylquinazoline Scaffold for the Development of High Affinity Fluorescent Probes for the Translocator Protein (TSPO)

Milite, C. et al.; J. Med. Chem., 2017, 60, 7897-7909

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Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a]pyridine: expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines

Bazin, M. A.; Marhadour, S.; Tonnerre, A.; Marchand, P.; Tetrahedron Letters, 2013, 54(39), 5378-5382

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Facile access to new C-glycosides and C-glycoside scaffolds incorporating functionalised aromatic moieties

Redpath, P.; Ness, K. A.; Rousseau, J.; Macdonald, S. J. F.; Migaud, M. E.; Carbohydrate Research, 2015, 402, 25-34

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Facile arene hydrogenation under flow conditions catalyzed by rhodium or ruthenium on carbon

Hattori, T.; Ida, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Eur. J. Org. Chem., 2015, 2015(11), 2492-2497

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Facile conversion of red phosphorus into soluble polyphosphide anions by reaction with potassium ethoxide

Dragulescu-Andrasi, A.; Miller, L. Z.; Chen, B.; McQuade, D. T.; Shatruk M.; Angew. Chem. Int. Ed., 2016, 55(12), 3904-3908

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Facile synthesis of bromo- and iodo-1,2,3-triazoles

Sakurada, I.; Tetrahedron Letters, 2017, 3188-3190

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Fast and Highly Selective Continuous-Flow Catalytic Hydrogenation of a Cafestol–Kahweol Mixture Obtained from Green Coffee Beans

Lima, F. A. et al.; ACS Omega, 2020, 5(40), 25712-25722

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Fast continuous alcohol amination employing a hydrogen borrowing protocol

Labes, R.; Mateos, C., Battilocchio, C.; Chen, Y.; Dingwall, P.; Cumming, G. R.; Rincon, J. A.; Nieves-Remacha, M. J.; Ley, S. V.; Green Chemistry, 2019, 21, 59-63

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Fatty acids residue from palm oil refining process as feedstock for lipase catalyzed monoacylglicerol production under batch and continuous flow conditions

Junior, I. I.; Flores, M. C.; Sutili, F. K.; Leite, S. G. F.; de M. e Miranda, L. S.; Leal, I. C. R.; de Souza, R. O. M. A.; Journal of Molecular Catalysis B: Enzymatic, 2012, 77, 53-58

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Features of oxa-bridge cleavage in hexahydro-3a,6-epoxyisoindol-1(4H)-ones: A concise method to access acetylisoindolones possessing anti-viral activity

Zaytsev, V. P.; Mertsalov, D. F.; Chervyakova, L. V.; Krishna, G.; Zubkov, F. I.; Dorovatovski, P. V.; Khrustalev, V. N.; Zarubaev, V. V.; Tetrahedron Lett., 2019, 60(43), 151204

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Feedback in Flow for Accelerated Reaction Development

Reizman, B. J. et al.; Acc. Chem. Res., 2016, 49(9), 1786-1796

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FeNi nanoparticles with carbon armor as sustainable hydrogenation catalysts: towards biorefineries

Chieffi, G.; Giordano, C.; Antonietti, M.; Esposito, D.; Journal of Materials Chemistry A, 2014, 2, 11591-11596

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Fine chemical syntheses under flow using SiliaCat catalysts

Ciriminna, R.; Pandarus, V.; Beland, F.; Pagliaro, M.; Catal. Sci. Technol., 2016, 6(13), 4678-4685

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First enantioselective total synthesis of (+)-(R)-pinnatolide using an symmetric domino allylation reaction

Tietze, L. F.; Wolfram, T.; Holstein, J. J.; Dittrich, B.; Org. Lett., 2012, 14(16), 4035-4037

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First example of alkyl–aryl Negishi cross-coupling in flow: Mild, efficient and clean introduction of functionalized alkyl groups

Egle, B.; Munoz, J.; Alonso, N.; De Borggraeve, W. M., de la Hoz, A.; Diaz-Ortiz, A.; Alcazar, J.; J. Flow Chem., 2014, 4(1), 22-25

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Fixed Bed Continuous Hydrogenations in Trickle Flow Mode: A Pharmaceutical Industry Perspective

Masson, E. et al.; Org. Process Res. Dev., 2022, Accepted manuscript

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Flash carboxylation: fast lithiation-carboxylation sequence at room temperature in continuous flow

Pieber, B.; Glasnov, T.; Kappe, C. O.; RSC Adv., 2014, 4, 13430-13433

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Flash flow pyrolysis: Mimicking flash vacuum pyrolysis in a high-temperature/high-pressure liquid-phase microreactor environment

Cantillo, D.; Sheibani, H.; Kappe, C. O.; J. Org. Chem., 2012, 77(5), 2463-2473

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Flow chemistry – A key enabling technology for (multistep) organic synthesis

Wegner, J.; Ceylan, S.; Kirschning, A.; Adv. Synth. Catal., 2012, 354, 17-57

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Flow chemistry approach for partial deuteration of alkynes: synthesis of deuterated taxol side chain

Chandrasekhar, S.; Vijaykumar, B. V. D.; Mahesh Chandra, B.; Raji Reddy, Ch.; Naresh, P.; Tetrahedron Letters, 2011, 52, 3865-3867

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Flow chemistry approaches directed at improving chemical synthesis

Baxendale, I. R.; Brocken, L.; Mallia, C. J.; Green Process. Synth., 2013, 2(3), 211-230

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Flow chemistry as a versatile tool for the synthesis of triazoles

Otvos, S. B.; Fulop, F.; Catal. Sci. Technol., 2015, 5(11), 4926-4941

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Flow chemistry based catalytic hydrogenation for improving the synthesis of 1-deoxynojirimycin (DNJ) from an L-sorbose derived precursor

Bennett, J. J. et al.; Carbohydrate Research, 2023, 529, 108845

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Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation

Mandity, I.; Fulop, F.; Nekka, I.; Bogdan, D.; Gati, T.; Beni, S.; Juhasz, T.; Palko, M.; Paragi, G.; Toth, G.; Chem. Commun., 2019, 55, 3061-3064

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Flow chemistry for designing sustainable chemical synthesis

Vaddula, B. R.; Gonzalez, M. A.; Chimica Oggi – Chemistry Today, 2013, 31, 16-20

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Flow Chemistry in Space – A Unique Opportunity to Perform Extraterrestrial Research

Sipos, G. et al.; J. Flow Chem., 2017, 7(3-4), 151-156

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Flow chemistry in the multi-step synthesis of natural products

Wan, L. et al.; Green Synth. Catal., 2022, Advance article

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Flow chemistry: Intelligent processing of gas-liquid transformations using a tube-in-tube reactor

Brzozowski, M.; O'Brien, M.; Ley, S. V.; Polyzos, A.; Acc. Chem. Res., 2015, 48(2), 349-362

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Flow chemistry – Microreaction technology comes of age

Jensen, K. F.; AIChE J., 2017, 63, 858-869

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Flow chemistry syntheses of natural products

Pastre, J. C.; Browne, D. L.; Ley, S. V.; Chem. Soc. Rev., 2013, 42, 8849-8869

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Flow chemistry: Towards a more sustainable heterocyclic synthesis

Brandao, P.; Pineiro, M.; Pinho e Melo, T. M. V. D.; Eur. J. Org. Chem., 2019, 2019(43), 7188-7217

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Flow chemistry vs. flow analysis

Trojanowicz, M.; Talanta, 2016, 146, 621-640

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Flow fine synthesis with heterogeneous catalysts

Masuda, K.; Ichitsuka T.; Koumura, N.; Sato, K.; Kobayashi, S.; Tetrahedron, 2018, 74(15), 1705-1730

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Flow Hydrogenation of 1,3,5-Trinitrobenzenes over Cu-Based Catalysts as an Efficient Approach for the Preparation of Phloroglucinol Derivatives

Shchurova, I. A. et al.; Synthesis, 2022, https://doi.org/10.1055/a-1807-3188

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Flow hydrogenation of 5-acetoxymethylfurfural over Cu-based catalysts

Nuzhdin, A. L. et al.; Mol. Cat., 2020, 494, 111132

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Flow hydrogenation of p-nitrophenol with nano-Ag/Al2O3

Paun, C.; Slowik, G.; Lewin, E.; Sa, J.; RSC Adv., 2016, 6, 87564-87568

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Flow-oriented synthetic design in the continuous preparation of the aryl piperazine drug flibanserin

Bana, P.; Szigetvari, A.; Koti, J.; Eles, J.; Greiner, I.; React. Chem. Eng., 2019, 4, 652-657

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Flow photochemistry — from microreactors to large-scale processing

Zhang, M. et al.; Current Opinion in Chemical Engineering, 2023, 39, 100897

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Flow reactors for drug discovery flow for reaction optimization, library synthesis, and scale up

Jones, R. V.; Csajagi, Cs.; Szekelyhidi, Zs.; Kovacs, I.; Borcsek, B.; Urge, L.; Darvas, F.; Chemistry Today, 2008, 26(3), 10-13

Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe

Plutschack, M. B.; McQuade, D. T.; Valenti, G.; Seeberger, P. H.; Beilstein J. Org. Chem., 2013, 9, 2022-2027

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Flow synthesis of annulated 5-aryl-substituted pyridines by tandem intramolecular inverse-electron-demand hetero-/retro-Diels–Alder reaction

Martin, R. E.; Lenz, M.; Alzieu, T.; Aebi, J. D.; Forzy, L.; Tetrahedron Letters, 2013, 54(49), 6703-6707

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Flow Synthesis of Biologically-Relevant Compound Libraries

Navarro, P. M. L. et al.; Molecules, 2020, 25, 909

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Flow synthesis of secondary amines over Ag/Al2O3 catalyst by one-pot reductive amination of aldehydes with nitroarenes

Artiukha, E. A. et al.; RSC Adv., 2017, 7, 45856-45861

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Fluoroacetamide Moieties as NMR Spectroscopy Probes for the Molecular Recognition of GlcNAc‐Containing Sugars: Modulation of the CH–π Stacking Interactions by Different Fluorination Patterns

Unione, L. et al.; Chem. Eur. J., 2017, 23, 3957-3965

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Formation of benzocyclobutenes from substituted oxocycloocta-2,8-diene-1,2-dicarboxylates

Bezensek, J.; Groselj, U.; Pockaj, M.; Svete, J.; Stanovnik, B.; Tetrahedron Letters, 2015, 56(42), 5705-5708

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Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors

Saluste, G.; Albarran, M. I.; Alvarez, R. M.; Rabal, O.; Ortega, M. A.; Blanco, C.; Kurz, G.; Salgado, A.; Pevarello, P.; Bischoff, J. R.; Pastor, J.; Oyarzabal, J.; PLoS One, 2012, 7(10), e45964

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From the Lindlar catalyst to supported ligand‐modified palladium nanoparticles: selectivity patterns and accessibility constraints in the continuous‐flow three‐phase hydrogenation of acetylenic compounds

Vile, G.; Almora-Barrios, N.; Mitchell, S.; Lopez, N.; Perez-Ramirez, J.; Chem. Eur. J., 2014, 20, 5926-5937

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Fully automated sequence-specific synthesis of α-peptides using flow chemistry

Knudsen, K. R.; Ladlow, M.; Bandpey, Z.; Ley, S. V.; J. Flow Chem., 2014, 4(1), 18-21

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Functional Group Interconversion Reactions in Continuous Flow Reactors

Leslie, A. et al.; Curr. Org. Chem., 2021, 25, 19, 2217-2231

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Furfural conversion over calcined Ti and Fe metal-organic frameworks under continuous flow conditions

Ratthiwal, J. et al.; Catalysis Communications, 2023, 177, 106649

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Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation

Brice, H.; Clayden, J.; Hamilton, S. D.; Beilstein J. Org. Chem., 2010, 6(22)

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Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor

Bartolini, D. et al.; J. Med. Chem., 2020, 63(7), 3701-3712

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General methods for the synthesis and late-stage diversification of 2,4-substituted 7-azaindoles

Varnes, J. G.; McGuire, T.; Meadows, R. E.; Barlaam, B.; Clark, J.; Cook, C. R.; Davison, G.; Dishington, A.; De Savi, C.; Donald, C.; Grebe, T.; Hande, S.; Hawkins, J.; Hird, A. W.; Holmes, J.; Lister, A.; Lucas, S.; Moore, J.; Moore, E.; Patel, A.; Pike, K. G.; Roberts, B.; Stark, A.; Stead, D.; Thakur, K.; Turner, P.; Vasbinder, M.; Yang, B.; Tetrahedron Letters, 2016, 57, 4718-4722

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Generation of Polar Semi-Saturated Bicyclic Pyrazoles for Fragment-Based Drug Discovery Campaigns

Luise, N. et al.; Chem. Eur. J., 2018, 24(41), 10443-10451

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Gram scale de novo synthesis of 2,4-diacetamido-2,4,6-trideoxy-d-galactose

Schmolzer, C.; Nowikow, C.; Kahlig, H.; Schmid, W.; Carbohydrate Research, 2013, 367, 1-4

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Green and Scalable Palladium‐on‐Carbon‐Catalyzed Tsuji–Trost Coupling Reaction Using an Efficient and Continuous Flow System

Cazorla, C. et al.; Eur. J. Org. Chem., 2017, 1078-1085

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Green and scalable procedure for extremely fast ligandless Suzuki-Miyaura cross-coupling reactions in aqueous IPA using solid-supported Pd in continuous flow

Mateos, C.; Rincon, J. A.; Martin-Hidalgo, B.; Villanueva, J.; Tetrahedron Letters, 2014, 55(27), 3701-3705

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Green Approach for Sustainable Production of Paraffin Fuel from CO2 Hydrogenation on Fe-MOF Catalyst

Ahmed, H. E. et al.; Journal of Environmental Chemical Engineering, 2023, Accepted manuscript

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Green chemistry articles of interest to the pharmaceutical industry

Andrews, I.; Dunn, P.; Hayler, J.; Himkley, B.; Hughes, D.; Kaptein, B.; Lorenz, K.; Methew, S.; Rammeloo, T.; Wang, L.; Wells, A.; White, T. D.; Org. Process Res. Dev., 2011, 15, 748-756

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Green Process Design for Reductive Hydroformylation of Renewable Olefin Cuts for Drop-In Diesel Fuels

Puschel, S. et al.; ChemSusChem, 2021, 14, 5226-5234

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Harnessing the versatility of continuous-flow processes: selective and efficient reactions

Mandity, I. M.; Otvos, S. B.; Szolosi, G.; Fulop, F.; Chem. Rec., 2016, 16, 1018-1033

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Hazards associated with laboratory scale hydrogenations

Chandra, T.; Zebrowski; J. P.; Journal of Chemical Health and Safety, 2016, 23(4), 16-25

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Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons

Belema, M.; Nguyen, V. N.; Romine, J. L.; St. Laurent, D. R.; Lopez, O. D.; Goodrich, J. T.; Nower, P. T.; O'Boyle, D. R.; Lemm, J. A.; Fridell, R. A.; Gao, M.; Fang, H.; Krause, R. G.; Wang, Y.; Oliver, A. J.; Good, A. C.; Knipe, J. O.; Meanwell, N. A.; Snyder, L. B.; J. Med. Chem., 2014, 57, 1995-2012

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Heterogeneous catalysis in continuous flow microreactors: a review of methods and applications

Tanimu, A.; Jaenicke, S.; Alhooshani, K.; Chem. Eng. J., 2017, 327, 792-821

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Heterogeneous Catalysis to Drive the Waste-to-Pharma Concept: From Furanics to Active Pharmaceutical Ingredients

Luque, R. et al.; Molecules, 2021, 26, 6738

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Heterogeneous catalytic hydrogenation reactions in continuous-flow reactors

Irfan, M.; Glasnov, N. T.; Kappe, O. C.; ChemSusChem, 2011, 12(3), 300-316

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Heterogeneous catalytic synthesis using microreactor technology

Frost, C. G.; Mutton, L.; Green Chem., 2010, 12, 1687-1703

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Heterogeneous enantioselective hydrogenation in a continuous-flow fixed-bed reactor system: Hydrogenation of activated ketones and their binary mixtures on Pt–alumina–cinchona alkaloid catalysts

Szollosi, G.; Makra, Zs.; Fekete, M.; Fulop, F.; Bartok, M.; Catal. Lett., 2012, 142(7), 889-894

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Heterogeneous hydrogenation reactions using a continuous flow high pressure device

Desai, B.; Kappe, C. O.; J. Comb. Chem., 2005, 7(5), 641-643

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Heterogeneous Palladium Catalysts in the Hydrogenation of the Carbon-carbon Double Bond

Grabovskii, S. A. et al.; Curr. Org. Chem., 2021, 25, 2, 315-329

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Heterogeneous versus homogeneous palladium catalysts for ligandless Mizoroki-Heck reactions: A comparison of batch/microwave and continuous‐flow processing

Glasnov, T. N.; Findenig, S.; Kappe, C. O.; Chem. Eur. J., 2009, 15, 1001-1010

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High-efficiency aminocarbonylation by introducing CO to a pressurized continuous flow reactor

Csajagi, Cs.; Borcsek, B.; Niesz, K.; Kovacs, I.; Szekelyhidi, Zs.; Bajko, Z.; Ugre, L.; Darvas, F.; Org. Lett., 2008, 10(8), 1589-1592

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High pressure in organic chemistry on the way to miniaturization

Benito-Lopez, F.; Egberink, E. J. M.; Reinhoudt, D. N.; Verboom, W.; Tetrahedron, 2008, 64(43), 10023-10040

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High-speed microwave assisted synthesis of SEA0400 – a selective inhibitor of the Na+/Ca2+ exchanger

de la Cruz, G. G.; Groschner, K.; Kappe, C. O.; Glasnov; T. N.; Tetrahedron Letters, 2012, 53, 3731-3734

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High-temperature Boc deprotection in flow and its application in multistep reaction sequences

Bogdan, R. A.; Charaschanya, M.; Dombrowski, A. W.; Wang, Y.; Djuric, S. W.; Org. Lett., 2016, 18(8), 1732-1735

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High-throughput Screening of Vanadium (IV) Oxide via Continuous Hydrothermal Flow Synthesis Reactor

Tran, M. K. et al.; Materials Chemistry, 2021, Working paper

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Highly active catalytic Ru/TiO2 nanomaterials for continuous production of γ-valerolactone

Xu, C.; Ouyang, W.; Munoz-Batista, M. J.; Fernandez-Garcia, M.; Luque, R.; ChemSusChem, 2018, 11(15), 2604-2611

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Highly Diastereoselective Chelation-Controlled 1,3-anti-Allylation of (S)-3-(Methoxymethyl)hexanal Enabled by Hydrate of Scandium Triflate

Masiuk, U. S. et al.; Symmetry, 2021, 13, 470

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Highly efficient 1,4-addition of aldehydes to nitroolefins

Otvos, S. B.; Mandity, I. M.; Fulop, F.; ChemSusChem, 2012, 5, 266-269

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Highly efficient iron(0) nanoparticle-catalyzed hydrogenation in water in flow

Hudson, R.; Hamasaka, G.; Osako, T.; Yamada, Y. M. A.; Li, C-J.; Uozumi, Y.; Moores, A.; Green Chem., 2013, 15, 2141-2148

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Highly efficient reversible addition-fragmentation chain‐transfer polymerization in ethanol/water via flow chemistry

Ye, P.; Cao, P-F.; Su, Z.; Advincula, R.; Polymer Int., 2017, 66(9), 1252-1258

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Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives

Lengyel, L.; Nagy, T. Zs.; Sipos, G.; Jones, R.; Dorman, Gy.; Urge, L.; Darvas, F.; Tetrahedron Letters, 2012, 53(7), 738-743

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Highly selective continuous-flow synthesis of potentially bioactive deuterated chalcone derivatives

Hsieh, C.; Otvos, S. B.; Wu, Y.; Mandity, I. M.; Chang, F.; Fulop, F.; ChemPlusChem, 2015, 80(5), 859-864

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Highly selective deuteration of pharmaceutically relevant nitrogen-containing heterocycles: a flow chemistry approach

Otvos, S. B.; Mandity, I. M.; Fulop, F.; Mol. Divers., 2011, 15, 605-611

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Highly selective hydrogenation of R‑(+)-limonene to (+)-p- 1‑menthene in batch and continuous flow reactors

Rubulotta, G.; Luska, K. L.; Urbina-Blanco, C. A.; Eifert, T.; Palkovits, R.; Quadrelli, E. A.; Thieuleux, C.; Leitner, W.; ACS Sustainable Chem. Eng., 2017, 5, 3762-3767

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Hit optimization of 5-substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) inhibitors with in vivo activity in model of mood disorders

Furlotti, G.; Alisi, M. A.; Cazzolla, N.; Dragone, P.; Durando, L.; Magaro, G.; Mancini, F.; Mangano, G.; Ombrato, R.; Vitiello, M.; Armirotti, A.; Capurro, V.; Lanfranco, M.; Ottonello, G.; Summa, M.; Reggiani, A.; J. Med. Chem., 2015, 58(22), 8920-8937

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HKUST-1 silica aerogel composites: novel materials for the separation of saturated and unsaturated hydrocarbons by conventional liquid chromatography

Nuzhdin, A. L.; Shalygin, A. S.; Artiukha, E. A.; Chibiryaev, A. M.; Bukhtiyarova, G. A.; Martyanov, O. N.; RSC Adv., 2016, 6, 62501-62507

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Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

Manzoni, L.; Belvisi, L.; Bianchi, A.; Conti, A.; Drago, C.; de Matteo, M.; Ferrante, L.; Mastrangelo, E.; Perego, P.; Potenza, D.; Scolastico, C.; Servida, F.; Timpano, G.; Vasile, F., Rizzo, V.; Seneci, P.; Bioorg. Med. Chem., 2012, 20, 6687-6708

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How the mode of Candida antarctica lipase B immobilization affects the continuous-flow kinetic resolution of racemic amines at various temperatures

Boros, Z.; Falus, P.; Markus, M.; Weiser, D.; Olah, M.; Hornyanszky, G.; Nagy, J.; Poppe, L.; Journal of Molecular Catalysis B: Enzymatic, 2013, 85-86, 119-125

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HPLC-UV-HRMS analysis of cannabigerovarin and cannabigerobutol, the two impurities of cannabigerol extracted from hemp

Tolomeo, F. et al.; J. Pharm. Biomed. Analysis, 2021, 203, 114215

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Hydrogenation of Aqueous Acetic Acid over Ru-Sn/TiO2 Catalyst in a Flow-Type Reactor, Governed by Reverse Reaction

Zhao, Y. et al.; Catalysts, 2020, 10, 1270

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Hydrogenation of Dinitrobenzenes to Corresponding Diamines Over Cu–Al Oxide Catalyst in a Flow Reactor

Nuzhdin, A. L. et al.; Catalysis Letters, 2023, https://doi.org/10.1007/s10562-023-04306-1

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Hydrogenation of nitroarenes to anilines in a flow reactor using polystyrene supported rhodium in a catalyst-cartridge (Cart-Rh@PS)

Sharma, S.; Yamini; Das, P.; New J. Chem., 2018, 43, 1764-1769

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Hydrogenation Properties of Nanostructured Tungsten Carbide Catalysts in a Continuous‐Flow Reactor

Braun, M. et al.; ChemCatChem, 2017, 9, 393-397

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Hydrothermal formose reaction

Kopetzki, D.; Antonietti, M.; New J. Chem., 2011, 35, 1787-1794

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Hyperbranched PDMAEMA-functionalized SiO2 microparticles: ATRP polymerization and grafting in a continuous flow reactor

Ge, J. et al.; MRS Communications, 2022, 12, 1147-1153

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Identification and Characterization of Carprofen as a Multitarget Fatty Acid Amide Hydrolase/Cyclooxygenase Inhibitor

Favia, A. D.; Habrant, D.; Scarpelli, R.; Migliore, M.; Albani, C.; Bertozzi, S. M.; Dionisi, M.; Tarozzo, G.; Piomelli, D.; Cavalli, A.; De Vivo, M.; J. Med. Chem., 2012, 55, 8807-8826

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Identification and validation of small molecule modulators of the NusB-NusE interaction

Cossar, P. J. et al.; Bioorg. Med. Chem. Lett., 2017, 162-167

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Identification of a new cannabidiol n-hexyl homolog in a medicinal cannabis variety with an antinociceptive activity in mice: cannabidihexol

Linciano, P. et al.; Sci. Rep., 2020, 10, 22019

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Identification of a novel orally bioavailable phosphodiesterase 10A inhibitor with efficacy in animal models of schizophrenia

Bartolome-Nebreda, J. M.; de Diego, S. A. A.; Artola, M.; Delgado, F.; Delgado, O.; Martin-Martin, M. L.; Martinez-Viturro, C. M.; Pena, M. A.; Tong, H. M.; Van Gool, M.; Alonso, J. M.; Fontana, A.; Macdonald, G. J.; Megens, A.; Langlois, X.; Somers, M.; Vanhoof, G.; Conde-Ceide, S.; J. Med. Chem., 2015, 58(2), 978-993

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Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington’s Disease

Ladduwahetty, T. et al.; J. Med. Chem., 2022, 65, 14, 9819-9845

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Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection

Yuan, Z. Q. et al.; J. Med. Chem., 2019, 62(3), 1385-1406

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Identification of the Clinical Candidate (R)‑(1-(4-Fluorophenyl)-6-((1-methyl‑1H‑pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro‑1H‑pyrazolo[3,4‑g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist

Belanoff, J. K. et al.; J. Med. Chem., 2017, 60, 3405-3421

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Immobilization of an Iridium(I)-NHC-Phosphine Catalyst for Hydrogenation Reactions under Batch and Flow Conditions

Kovacs, H. et al.; Catalysts, 2021, 11, 656

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Immobilized iron oxide nanoparticles as stable and reusable catalysts for hydrazine‐mediated nitro reductions in continuous flow

Moghaddam, M. M.; Pieber, B.; Glasnov, T.; Kappe, C. O.; ChemSusChem, 2014, 7(11), 3122-3131

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Immobilized phosphine–phosphite rhodium complexes: highly active and enantioselective catalysts for asymmetric hydrogenation under continuous flow conditions

Madarasz, J.; Nanasi, B.; Kovacs, J.; Balogh, S.; Farkas, G.; Bakos, J.; Monatsh. Chem., 2018, 149(1), 19-25

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Immobilized transition metals as catalysts for cross-couplings in continuous flow — A critical assessment of the reaction mechanism and metal leaching

Cantillo, D.; Kappe, C. O.; ChemCatChem, 2014, 6(12), 3286-3305

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Important industrial procedures revisited in flow: very efficient oxidation and N-alkylation reactions with high atom-economy

Sipos, G.; Gyollai, V.; Dorman, G.; Kocsis, L.; Jones, R. V.; Darvas, F.; Journal of Flow Chemistry, 2013, 3(2), 51-58

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Improved and scalable synthesis of building blocks for the modular synthesis of teraryl-based alpha-helix mimetics

Trobe, M.; Breinbauer, R.; Monatsh. Chem., 2016, 147(3), 509-521

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Improved continuous flow processing: benzimidazole ring formation via catalytic hydrogenation of an aromatic nitro compound

Chen, J.; Przyuski, K.; Roemmele, R.; Bakale, R. P.; Org. Process Res. Dev., 2014, 18(11), 1427-1433

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Improved potency of pyridin-2(1H)one derivatives for the treatment of mechanical allodynia

Visseq, A. et al.; Eur. J. Med. Chem., 2021, 225, 113748

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Improving productivity of multiphase flow aerobic oxidation using a tube-in-tube membrane contactor

Burkholder, M.; Gilliland, S. E.; Luxon, A.; Tang, C.; Gupton, B. F.; Catalysts, 2019, 9(1), 95

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Improving the efficiency of the Diels–Alder process by using flow chemistry and zeolite catalysis

Seghers, S. et al.; Green Chemistry, 2017, 19, 237-248

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Improving the sustainability and safety of ursodeoxycholic acid synthesis in continuous flow process with water

Kim, H. et al.; J. Ind. Eng. Chem., 2023, 119, 327-334

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In situ sulfidation of Pd/C: A Straightforward method for chemoselective conjugate reduction by continuous hydrogenation

Moore, J. C.; Howie, R. A.; Bourne, S. L.; Jenkins, G. N.; Licence, P.; Poliakoff, M.; George, M. W.; ACS Sustainable Chem. Eng., 2019, 7(19), 16814-16819

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In vitro reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors

Tan, G-Y.; Zhu, F.; Deng, Z.; Liu, T.; Synthetic and Systems Biotechnology, 2016, 1, 25-33

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Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites

Shamovsky, I.; de Graaf, C.; Alderin, L.; Bengtsson, M.; Bladh, H.; Börjesson, L.; Connolly, S.; Dyke, H. J.; van den Heuvel, M.; Johansson, H.; Josefsson, B.; Kristoffersson, A.; Linnanen, T.; Lisius, A.; Mannikko, R.; Norden, B.; Price, S.; Ripa, L.; Rognan, D.; Rosendahl, A.; Skrinjar, M.; Urbahns, K.; J. Med. Chem., 2009, 52, 7706-7723

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Innovative benign-by-design flow chemistry protocols: from bio(nano)materials synthesis to biomass/waste valorisation

Wang, B.; Balu, A. M.; Xuan, J.; Gonzalez-Arellano, C.; Bai, Z.; Luque, R.; Chemistry Today, 2016, 34(6), 58-63

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Insights into the activity, selectivity and stability of heterogeneous catalysts in the continuous flow hydroconversion of furfural

Garcia-Olmo, A. J.; Yepez, A.; Balu, A. M.; Romero, A. A.; Li, Y.; Luque, R.; Catal. Sci. Technol., 2016, 6(13), 4705-4711

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Insights into the selective hydrogenation of levulinic acid to γ-valerolactone using supported mono- and bimetallic catalysts

Al-Naji, M.; Yepez, A.; Balu, A. M.; Romero, A. A.; Chen, Z.; Wilde, N.; Li, H.; Shih, K.; Glaser, R.; Luque, R.; Journal of Molecular Catalysis A: Chemical, 2016, 417, 145-152

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Integrated Suzuki Cross-Coupling/Reduction Cascade Reaction of meta-/para-Chloroacetophenones and Arylboronic Acids under Batch and Continuous Flow Conditions

Li, Y. et al.; Chem. Asian J., 2021, 16(16), 2338-2345

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Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Ingham, R. J.; Battilocchio, C.; Hawkins, J. M.; Ley, S. V.; Beilstein J. Org. Chem., 2014, 10, 641-652

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Intensified Continuous Flow Michaelis-Arbuzov Rearrangement toward Alkyl Phosphonates

Toupy, T. et al.; Org. Process Res. Dev., 2022, 26(2), 467-478

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Niesz, K.; Csajagi, Cs.; Borcsek, B.; Jones, R. V.; Darvas, F.; Nanotechnology, 2007, 4, 426-429

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Interfacial acidity in ligand-modified ruthenium nanoparticles boosts the hydrogenation of levulinic acid to gamma-valerolactone

Albani, D. et al.; Green Chemistry, 2017, 19, 2361-2370

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Intramolecular aglycon delivery enables the synthesis of 6-deoxy-β-d-manno-heptosides as fragments of Burkholderia pseudomallei and Burkholderia mallei capsular polysaccharide

Kenfack, M. T.; Bleriot, Y.; Gauthier, C.; J. Org. Chem., 2014, 79(10), 4615-4634

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Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism

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Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs)

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Ion-exchange resin-supported palladium catalysts for hydrodehalogenation of aryl halides under batch and continuous flow conditions

Czegeni, C. E. et al.; Inorganica Chimica Acta, 2023, 556, 121613

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Ion exchange resins: Catalyst recovery and recycle

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Iridium(I)-catalyzed ortho-directed hydrogen isotope exchange in continuous-flow reactors

Habraken, E.; Haspeslagh, P.; Vliegen, M.; Noel, T.; J. Flow Chem., 2015, 5(1), 2-5

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Iridium(I)-NHC-phosphine complex-catalyzed hydrogen generation and storage in aqueous formate/bicarbonate solutions using a flow reactor – Effective response to changes in hydrogen demand

Horvath, H.; Papp, G.; Kovacs, H.; Katho, A.; Joo, F.; Int. J. Hydrogen Energy, 2019, 44(53), 28527-28532

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Isolation and characterization of anti-adenoviral secondary metabolites from marine actinobacteria

Strand, M.; Carlsson, M.; Uvell, H.; Islam, K.; Edlund, K.; Cullman, I.; Altermark, B.; Mei, Y-F.; Elofsson, M.; Willassen, N. P.; Wadell, G.; Almqvist, F. Mar. Drugs, 2014, 12(2), 799-821

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Landscape and opportunities for active pharmaceutical ingredient manufacturing in developing African economies

Panayides, J. L.; Riley, D. L.; Chikwamba, R.; Strydom, I.; React. Chem. Eng., 2019, 4, 457-489

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Latest highlights in liquid-phase reactions for organic synthesis in microreactors

Protasova, L. N.; Bulut, M.; Ormerod, D.; Buekenhoudt, A.; Berton, J.; Stevens, C. V.; Org. Process Res. Dev., 2013, 17(5), 760-791

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Less Cytotoxic Protoflavones as Antiviral Agents: Protoapigenone 1′-O-isopropyl ether Shows Improved Selectivity Against the Epstein–Barr Virus Lytic Cycle

Vagvolgyi, M. et al.; Int. J. Mol. Sci., 2019, 20, 6269

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Lewis Acid Triggered Vinylcyclopropane−Cyclopentene Rearrangement

Ivanova, O. A. et al.; J. Org. Chem., 2018, 83, 543-560

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Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound

Tarleton, M.; Gilbert, J; Robertson, J. M.; McCluskey, A.; Sakoff, A. J; MedChemComm, 2011, 2, 31-37

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Library synthesis of cardiomyogenesis inducing compounds using an efficient two-step-one-flow process

Schon, M.; Dreier, D.; Schnurch, M.; Mihovilovic, M. D.; Monatsh. Chem., 2016, 147(3), 523-532

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Life cycle analysis within pharmaceutical process optimization and intensification: case study of active pharmaceutical ingredient production

Ott, D.; Kralisch, D.; Dencic, I.; Hessel, V.; Laribi, Y.; Perrichon, P. D.; Berguerand, C.; Kiwi-Minsker, L.; Loeb, P.; ChemSusChem, 2014, 7, 3521-3533

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Ligand ordering determines the catalytic response of hybrid palladium nanoparticles in hydrogenation

Albani, D.; Vile, G.; Mitchell, S.; Witte, P. T.; Almora-Barrios, N.; Verel, R.; Lopez, N.; Perez-Ramirez, J.; Catal. Sci. Technol., 2016, 6(6), 1621-1631

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Lipase-catalyzed kinetic resolution of 2-methylene-substituted cycloalkanols in batch and continuous-flow modes

Tomin, A.; Hornyanszky, G.; Kupai, K.; Dorko, Zs.; Urge, L.; Darvas, F.; Poppe, L.; Process Biochemistry, 2010, 45(6), 859-865

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Lipase-catalyzed monostearin synthesis under continuous flow conditions

Junior, I. I.; Flores, M. C.; Sutili, F. K.; Leite, S. G. F.; Miranda, L. S. de M.; Leal, I. C. R.; de Souza, R. O. M. A.; Org. Process Res. Dev., 2012, 16(5), 1098-1101

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Liquid phase oxidation chemistry in continuous-flow microreactors

Gemoets, H. P. L.; Su, Y.; Shang, M.; Hessel V.; Luque, R.; Noel, T.; Chem. Soc. Rev., 2016, 45, 83-117

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Living with our machines: Towards a more sustainable future

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Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions

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Maximizing hydrogen utilization efficiency in tandem hydrogenation of nitroarenes with ammonia borane

Shen, M. et al.; Green Chemistry, 2023, Advance article

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Measurement of supramolecular effective molarities for intramolecular H-bonds in zinc porphyrin-imidazole complexes

Jinks, M. A.; Sun, H.; Hunter, C. A.; Org. Biomol. Chem., 2014, 12, 1440-1447

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Mechanistic insights into copper(I)‐catalyzed azide‐alkyne cycloadditions using continuous flow conditions

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Mechanochemical synthesis of Cu2S bonded 2D-sulfonated organic polymers: continuous production of dimethyl carbonate (DMC) via preheating of reactants

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Mechanochemical Synthesis of Nickel-Modified Metal-Organic Frameworks for Reduction Reactions

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Merging single-atom-dispersed silver and carbon nitride to a joint electronic system via copolymerization with silver tricyanomethanide

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Mesoporous carbon supported Cu as the efficient catalyst for flow hydrogenation processes toward formation of products with pharmaceutical potential

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Metal-catalyzed amidation

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Metal-free synthesis of an estetrol key intermediate under intensified continuous flow conditions

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Metathesis of cardanol over ammonium tagged Hoveyda-Grubbs type catalyst supported on SBA-15

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Methods for the synthesis of indole-3-carboxylic acid esters

Litvinova, V. A.; Tikhomirov, A. S.; Chemistry of Heterocyclic Compounds, 2018, 54, 923-925

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Methylation using dimethylcarbonate catalysed by ionic liquids under continuous flow conditions

Glasnov, T. N.; Holbrey, J. D.; Kappe, C. O.; Seddon, K. R.; Yan, T.; Green Chem., 2012, 14, 3071-3076

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Micro reactors, flow reactors and continuous flow synthesis

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Micro-total process system machine (μ-TPSM) for rapid synthesis of antiretroviral darunavir

Chauhan, R. et al.; React. Chem. Eng., 2023, Advance article

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Microfluidic asymmetrical synthesis and chiral analysis

Kochetkov, K. A. et al.; J. Ind. Eng. Chem., 2022, 115, 62-91

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Microfluidics in commercial applications; an industry perspective

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Microreactors for peptide synthesis: looking through the eyes of twenty first century !!!

Ramesh, S.; Cherkupally, P.; de la Torre, B. G.; Govender, T.; Kruger, H. G.; Albericio, F.; Amino Acids, 2014, 46, 2091-2104

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Microwave-assisted and continuous flow multistep synthesis of 4-(pyrazol-1-yl)carboxanilides

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Microwave-assisted grafting to MCM-41 silica and its application as catalyst in flow chemistry

Oliverio, M.; Procopio, A.; Glasnov, T. N.; Goessler, W.; Kappe, C. O.; Aust. J. Chem., 2011, 64, 1522-1529

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Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters

Desai, B.; Dallinger, D.; Kappe, C. O.; Tetrahedron, 2006, 62, 4651-4664

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Microwave-assisted synthesis of medium-sized heterocycles

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Microwave chemistry enabling the synthesis of biologically relevant amines

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Microwave heating and conventionally-heated continuous-flow processing as tools for performing cleaner palladium-catalyzed decarboxylative couplings using oxygen as the oxidant – a proof of principle study

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Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library

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Mild and selective hydrogenation of nitro compounds using palladium nanoparticles supported on amino‐functionalized mesocellular foam

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Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507

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Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB)

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Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN)

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Modeling, synthesis and biological evaluation of potential retinoid X receptor‐selective agonists: Novel halogenated analogues of 4‐[1‐(3,5,5,8,8‐pentamethyl‐5,6,7,8‐tetrahydro‐2‐naphthyl)ethynyl]benzoic acid (Bexarotene)

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Molecularly imprinted hydrogels as functional active packaging materials

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Molecularly imprinted polymers for cleanup and selective extraction of curcuminoids in medicinal herbal extracts

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Monitoring glycan-protein interactions by NMR spectroscopic analysis: A simple chemical tag that mimics natural CH–π interactions

Calle, L. P.; Echeverria, B.; Franconetti, A.; Serna, S.; Fernandez-Alonso, M. C.; Diercks, T.; Canada, F. J.; Arda, A.; Reichardt, N. C.; Jimenez-Barbero, J.; Chem. Eur. J., 2015, 21(32), 11408-11416

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Multi-step continuous-flow synthesis

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Multi-step solvent-free 3 m2 footprint pilot miniplant for the synthesis of annual half ton rufinamide precursor

Gelonch, M. E.; de Leon Izeppi, G. A.; Kirschneck, D.; Hessel, V.; ACS Sustainable Chem. Eng., 2019, 7(20), 17237-17251

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Multigram-scale flow synthesis of the chiral key intermediate of (−)-paroxetine enabled by solvent-free heterogeneous organocatalysis

Otvos, S. B.; Pericas, M. A.; Kappe, C. O.; Chem. Sci., 2019, 10, 11141-11146

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Multigram Synthesis of Tetrasubstituted Dihydrobenzofuran GSK973 Enabled by High-Throughput Experimentation and a Claisen Rearrangement in Flow

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Multistep continuous‐flow synthesis in medicinal chemistry: Discovery and preliminary structure-activity relationships of CCR8 ligands

Petersen, T. P.; Mirsharghi, S.; Rummel, P. C.; Thiele, S.; Rosenkilde, M. M.; Ritzen, A.; Ulven, T.; Chem. Eur. J., 2013, 19(28), 9343-9350

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Multistep continuous-flow synthesis of condensed benzothiazoles

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Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties as novel synthetic polyphenols directed against HIV-1

Flores, A.; Camarasa, M. J.; Perez-Perez, M. J.; San-Felix, A.; Balzarini, J.; Quesada, E.; Org. Biomol. Chem., 2014, 12, 5278-5294

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My twenty years in microwave chemistry: from kitchen ovens to microwaves that aren’t microwaves

Kappe, C. O.; Chem. Rec., 2019, 19(1), 15-39

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N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist

Boldron, C.; Besse, A.; Bordes, M.; Tissandie, S.; Yvon, X.; Gau, B.; Badorc, A.; Rousseaux, T.; Barre, G.; Meneyrol, J.; Zech, G.; Nazare, M.; Fossey, V.; Pflieger, A.; Bonnet-Lignon, S.; Millet, L.; Briot, C.; Dol, F.; Herault, J.; Savi, P.; Lassalle, G.; Delesque, N.; Herbert, J.; Bono, F.; J. Med. Chem., 2014, 57(17), 7293-7316

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N-Acetylation of Amines in Continuous-Flow with Acetonitrile—No Need for Hazardous and Toxic Carboxylic Acid Derivatives

Orsy, G. et al.; Molecules, 2020, 25, 1985

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Nafion‐H‐catalyzed high‐temperature/high‐pressure synthesis of a triarylmethane in continuous‐flow mode

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Nanocatalysis in continuous flow: supported iron oxide nanoparticles for the heterogeneous aerobic oxidation of benzyl alcohol

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Nanocatalysis in flow

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Nanocubes of Palladium, Simple, Green Approach and Catalytic Properties Under Continuous Hydrogenation System

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Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow

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Nanoparticle synthesis completed with in situ catalyst preparation performed on a high-pressure high-temperature continuous flow reactor

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Nanoscale Pd supported on 3D porous carbon for enhanced selective oxidation of benzyl alcohol

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Nanosized palladium on phosphorus-incorporated porous carbon frameworks for enhanced selective phenylacetylene hydrogenation

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Nanosizing Pd on 3D porous carbon frameworks as effective catalysts for selective phenylacetylene hydrogenation

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Nanostructured Carbon Nitride for Continuous-Flow Trifluoromethylation of (Hetero)arenes

Sivo, A. et al.; ACS Sustainable Chem. Eng., 2023, 11(13), 5284–5292

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Nanotechnology tools in pharmaceutical R&D

Kumar, C. S. S. R.; Materials Today, 2010, 12, 24-30

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Natural‐product‐like spiroketals and fused bicyclic acetals as potential therapeutic agents for B‐cell chronic lymphocytic leukaemia

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Natural product synthesis on the fly – multistep continuous reaction shows the power of automated flow synthesis

Ritter, S. K.; Chemical & Engineering News, 2006, 84(10), 17

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New copper-containing catalysts based on modified amorphous silica and their use in flow azide—alkyne cycloaddition

Burilov, V. A.; Nurmukhametova, A. N.; Belov, R. N.; Mironova, D. A.; Vorob'ev, V. V.; Osin, Yu. N.; Antipin, I. S.; Russian Chemical Bulletin Int. Ed., 2018, 67, 461-468

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New data in the enantioselective hydrogenation of ethyl pyruvate on Pt-cinchona chiral catalyst using continuous-flow fixed-bed reactor system: The origin of rate enhancement

Szollosi, Gy.; Cserenyi, Sz.; Balazsik, K.; Fulop, F.; Bartok, M.; Journal of Molecular Catalysis A: Chemical, 2009, 305, 155-160

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New data on the Orito reaction: Effect of substrate structure on nonlinear phenomenon

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New data to the origin of rate enhancement on the Pt-cinchona catalyzed enantioselective hydrogenation of activated ketones

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New gonadotropin-releasing hormone glycolipids with direct antiproliferative activity and gonadotropin-releasing potency

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New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics

Pilkington-Miksa, M.; Araldi, E. M.; Arosio, D.; Belvisi, L.; Civera, M.; Manzoni, L.; Org. Biomol. Chem., 2016, 14(12), 3221-3233.

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Nickel-catalyzed reductive [2+2] cycloaddition of alkynes

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Nitro lignin-derived nitrogen-doped carbon as an efficient and sustainable electrocatalyst for oxygen reduction

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Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis

Jarrad, A. M.; Debnath, A.; Miyamoto, Y.; Hansford, K. A.; Pelington, R.; Butler, M. S.; Bains, T.; Karoli, T.; Blaskovich, M. A. T.; Eckmann, L.; Cooper, M. A.; Eur. J. Med. Chem., 2016, 120, 353-362

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Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

Gauthier, C.; Chassagne, P.; Theillet, F. X.; Guerreiro, C.; Thouron, F.; Nato, F.; Delepierre, M.; Sansonetti, P. J.; Phalipon, A.; Mulard, L. A.; Org. Biomol. Chem., 2014, 12, 4218-4232

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Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation

Mounier, L. et al.; J. Med. Chem., 2020, 63(22), 13680-13694

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Novel derivatives of usnic acid effectively inhibiting reproduction of influenza A virus

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Novel evidence on the role of the nucleophilic intermediate complex in the Orito-reaction: Unexpected inversion in the enantioselective hydrogenation of 2,2,2-trifluoroacetophenone on Pt-cinchona chiral catalyst using continuous-flow fixed-bed reactor

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Novel process windows for enabling, accelerating and uplifting flow chemistry

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Novel spirotetracyclic zwitterionic dual H1/5-HT2A receptor antagonists for the treatment of sleep disorders

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Nucleophilic aromatic substitution of heterocycles using a high-temperature and high-pressure flow reactor

Charaschanya, M.; Bogdan, A. R.; Wang, Y.; Djuric, S. W.; Tetrahedron Letters, 2016, 57(9), 1035-1039

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Nucleophilic Dearomatization of Activated Pyridines

Bertuzzi G. et al.; Catalysts, 2018, 8, 632

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Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1

Manka, J. T.; Rodriguez, A. L.; Morrison, R. D.; Venable, D. F.; Cho, H. P.; Blobaum, A. L.; Daniels, J. S.; Niswender, C. M.; Conn, P. J.; Lindsley, C. W.; Emmitte, K. A.; Bioorg. Med. Chem. Lett., 2013, 23(18), 5091-5096

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On-the-fly Catalyst Accretion and Screening in Chemoselective Flow Hydrogenation

Gizinski, D. et al.; ChemCatChem, 2018, 10(17), 3641-3646

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On the regioselectivity of the Gould–Jacobs reaction: Gas-phase versus solution-phase thermolysis

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One-For-All Polyolefin Functionalization: Active Ester as Gateway to Combine Insertion Polymerization with ROP, NMP, and RAFT

Dau, H. et al.; Angew. Chem. Int. Ed., 2022, 61(33), e202205931

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One-pot multi-step synthesis of gamma-valerolactone from furfuryl alcohol: Microwave vs continuous flow reaction studies

Lazaro, N. et al.; Fuel, 2023, 334, 126439

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One-pot reductive amination of aldehydes with nitroarenes over an Au/Al2O3 catalyst in a continuous flow reactor

Artiukha, E. A.; Nuzhdin, A. L.; Bukhtiyarova, G. A.; Zaytsev, S. Yu.; Plyusnin, P. E.; Shubinbc, Yu. V.; Bukhtiyarov, V. I.; Cat. Sci. Technol., 2015, 5(10), 4741-4745

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One-pot synthesis of secondary amines from nitroarenes and aldehydes on supported copper catalysts in a flow reactor: The effect of the support

Artyukha, E. A.; Nuzhdin, A. L.; Bukhtiyarova, G. A.; Derevyannikova, E. A.; Gerasimov, E. Yu.; Gladkii, A. Yu.; Bukhtiyarov, V. I.; Kinetics and Catalysis, 2018, 59(5), 593-600

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Online monitoring and analysis for autonomous continuous flow self-optimizing reactor systems

Fabry, D. C.; Sugiono, E.; Rueping M.; React. Chem. Eng., 2016, 1, 129-133

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Optically pure, structural, and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach

Liu, M.; Mountford, S. J.; Richardson, R. R.; Groenen, M.; Holliday, N. D.; Thompson, P. E.; J. Med. Chem., 2016, 59(13), 6059-6069

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Optimisation of conditions for O‐benzyl and N‐benzyloxycarbonyl protecting group removal using an automated flow hydrogenator

Knudsen, K. R.; Holden, J.; Ley, S. V.; Ladlow, M.; Adv. Synth. Catal., 2007, 349, 535-538

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Optimization of novel indazoles as highly potent and selective inhibitors of phosphoinositide 3-kinase δ for the treatment of respiratory disease

Down, K.; Amour, A.; Baldwin, I. R.; Cooper, A. W. J.; Deakin, A. M.; Felton, L. M.; Guntrip, S. B.; Hardy, C.; Harrison, Z. A.; Jones, K. L.; Jones, P.; Keeling, S. E.; Le, J.; Livia, S.; Lucas, F.; Lunniss, C. J.; Parr, N. J.; Robinson, E.; Rowland, P.; Smith, S.; Thomas, D. A.; Vitulli, G.; Washio, Y.; Hamblin, J. N.; J. Med. Chem., 2015, 58(18), 7381-7399

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Optimized Conditions for Passerini-Smiles Reactions and Applications to Benzoxazinone Syntheses

Martinand-Lurin, E. et al.; Molecules, 2016, 21, 1257

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Optimized Conditions for the Palladium-Catalyzed Hydrogenolysis of Benzyl and Naphthylmethyl Ethers: Preventing Saturation of Aromatic Protecting Groups

Crawford, C. et al.; Eur. J. Org. Chem., 2020, 3332-3337

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Organic synthesis: March of the machines

Ley, S. V.; Fitzpatrick, D. E.; Ingham, R. J.; Myers, R. M.; Angewandte Chemie Int. Ed., 2015, 54(11), 3449-3464

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Origin of problems related to Staudinger reduction in carbopeptoid syntheses

Csordas, B.; Nagy, A.; Harmat, V.; Zsoldos-Mady, V.; Leveles, I.; Pinter, I.; Farkas, V.; Perczel, A.; Amino Acids, 2016, 48(11), 2619-2633

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Origin of the rate enhancement and enantiodifferentiation in the heterogeneous enantioselective hydrogenation of 2,2,2-trifluoroacetophenone over Pt/alumina studied in continuous-flow fixed-bed reactor system

Szollosi, Gy.; Cserenyi, Sz.; Bucsi, I.; Bartok, T.; Fulop, F.; Bartok, M.; Applied Catalysis A: General, 2010, 382, 263-271

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Out-smarting smart drug modafinil through flow chemistry

Silva-Brenes, D. V. et al.; Green Chemistry, 2022, 24, 2094-2103

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Oxazolomycins: Natural product lead structures for novel antibacterials by click fragment conjugation

Bagwell, C. L.; Moloney, M. G.; Yaqoob, M.; Bioorg. Med. Chem. Lett., 2010, 20(7), 2090-2094

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p-Nitrophenol flow hydrogenation with nano-Cu2O grafted on polymeric resin

Paun, C.; Gizinski, D.; Zienkiewicz-Machnik, M.; Banas, D.; Kubala-Kukus, A.; Sa, J.; Catalysis Communications, 2017, 92, 61-64

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Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling in Continuous Flow

Bruniaux. S. et al.; Catalysts, 2017, 7, 146-169

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Palladium on carbon-catalyzed Suzuki-Miyaura coupling reaction using an efficient and continuous flow system

Hattori, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Catalysts, 2015, 5, 18-25

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Papain‐specific activating esters in aqueous dipeptide synthesis

de Beer, R. J. A. C.; Zarzycka, B.; Mariman, M.; Amatdjais-Groenen, H. I. V.; Mulders, M. J.; Quaedflieg, P. J. L. M.; van Delft, F. L.; Nabuurs, S. B.; Rutjes, F. P. J. T.; ChemBioChem, 2012, 13(9), 1319-1326

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Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor

Miller, D. C. et al.; J. Med. Chem., 2022, 65(9), 6513-6540

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Parallel synthesis of 1,2,4-triazole derivatives using microwave and continuous-flow techniques

Szommer T.; Lukacs A.; Kovacs J.; Szabo, M. J.; Hoffmann M. G.; Schmitt M. H.; Gerencser J.; Mol. Divers., 2012, 16(1), 81-90

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Particle-based immobilized enzymatic reactors in microfluidic chips

Kecskemeti, A. et al.; Talanta, 2017, 180, 211-228

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Pd nanoparticles on carbon layer wrapped 3D TiO2 as efficient catalyst for selective oxidation of benzyl alcohol

Wu, Y. et al.; Chem. Phys. Lett., 2018, 712, 149-154

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Pd-P nanoalloys supported on porous carbon frame as efficient catalyst for benzyl alcohol oxidation

Guo, W.; Niu, S.; Shi, W.; Zhang, B.; Yu, W.; Xie, Y.; Ji, X.; Wu, Y.; Su, D.; Shao, L.; Catal. Sci. Technol., 2018, 8, 2333-2339

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Pd@ionosilica as heterogeneous hydrogenation catalyst for continuous flow reductive upgrade of cinnamaldehyde

Braun, M. et al.; Chem. Tech. Biotech., 2017, 92, 2229-2235

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Peptide Synthesis Utilizing Micro‐flow Technology

Otake, Y. et al.; Chem. Asian J., 2018, 13(24), 3818-3832

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Pharmacokinetics-Driven Evaluation of the Antioxidant Activity of Curcuminoids and Their Major Reduced Metabolites—A Medicinal Chemistry Approach

Girst, G. et al.; Molecules, 2021, 26, 3542

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Photocatalytic Activity of Sulfanyl Porphyrazine/Titanium Dioxide Nanocomposites in Degradation of Organic Pollutants

Koczorowski, T. et al.; Materials, 2022, 15(20), 7264

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Photocatalytic Activity of the Oxidation Stabilized Ti3C2Tx MXene in Decomposing Methylene Blue, Bromocresol Green and Commercial Textile Dye

Bury, D. et al.; Small Methods, 2023, 7(8), 2201252

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Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor

Salamoun, J. M.; McQueeney, K. E.; Patil, K.; Geib, S. J.; Sharlow, E. R.; Lazo, J. S.; Wipf, P.; Org. Biomol. Chem., 2016, 14(27), 6398-6402

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Polysaccharides from Burkholderia species as targets for vaccine development, immunomodulation and chemical synthesis

Cloutier, M.; Muru, K.; Ravicoularamin, G.; Gauthier, C.; Nat. Prod. Rep., 2018, 35, 1251-1293

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Polystyrene Resins: Versatile and Economical Support for Heterogeneous Nanocatalysts in Sustainable Organic Reactions

Sharma, A. S. et al.; ChemCatChem, 2023, Accepted manuscript

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Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure–activity relationship (SAR) studies

Nuzzi, A.; Fiasella, A.; Ortega, J. A.; Pagliuca, C.; Ponzano, S.; Pizzirani, D.; Bertozzi, S. M.; Ottonello, G.; Tarozzo, G.; Reggiani, A.; Bandiera, T.; Bertozzi, F.; Piomelli, D.; Eur. J. Med. Chem., 2016, 111, 138-159

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Potentiating N-Hydroxyphthalimide Catalyzed Aerobic Aldehyde Oxidations in Continuous Flow

Kappe, C. O. et al.; Adv. Synth. Catal., 2022, Accepted manuscript

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Practical and Scalable Method for Manufacturing AZD4604, A Potent and Selective JAK1 Inhibitor

Pithani, S. et al.; Org. Process Res. Dev., 2023, Accepted manuscript

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Practical synthesis of (S)-pyrrolidin-2-yl-1H-tetrazole, incorporating efficient protecting group removal by flow-reactor hydrogenolysis

Franckevicius, V.; Knudsen, K. R.; Ladlow, M.; Longbottom, D. A.; Ley, S. V.; Synlett, 2006, 6, 889-892

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Preclinical characterization of the FAAH inhibitor JNJ-42165279

Keith, J. M.; Jones, W. M.; Tichenor, M.; Liu, J.; Seierstad, M.; Palmer, J. A.; Webb, M.; Karbarz, M.; Scott, B. P.; Wilson, S. J.; Luo, L.; Wennerholm, M. L.; Chang, L.; Rizzolio, M.; Rynberg, R.; Chaplan, S. R.; Breitenbucher, J. G.; ACS Med. Chem. Lett., 2015, 6(12), 1204-1208

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Precursor Nuclearity and Ligand Effects in Atomically-Dispersed Heterogeneous Iron Catalysts for Alkyne Semi-Hydrogenation

Faust Akl, D. et al.; ChemCatChem, 2021, 13(14), 3247-3256

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Prediction of Optimal Conditions of Hydrogenation Reaction Using the Likelihood Ranking Approach

Afonina, V. A. et al.; Int. J. Mol. Sci., 2022, 23, 248

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Preparation of HKUST-1@silica aerogel composite for continuous flow catalysis

Shalygin, A. S.; Nuzhdin, A. L.; Bukhtiyarova, G. A.; Martyanov, O. N.; J. Sol-Gel Sci. Technol., 2017, 84(3), 446-452

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Preparation of metal and metal oxide doped silica hollow spheres and the evaluation of their catalytic performance

Diacon, A. et al.; Colloid Polym. Sci., 2020, 298, 1401-1410

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Preparation of vinyl ethers using a Wittig approach, and their subsequent hydrogenation employing continuous-flow processing

Balti, M.; Efrit, M. L.; Leadbeater, N. E.; Tetrahedron Lett., 2016, 57, 1804-1806

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Present and future of cyclopropanations in fragrance chemistry

Schroder, F.; Chem. Biodivers., 2014, 11(11), 1734-1751

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Process development of a potent glucosylceramide synthase inhibitor

Cooper, C. G. F.; Lee, E. R.; Silva, R. A.; Bourque, A. J.; Clark, S.; Katti, S.; Nivorozkhin, V.; Org. Process Res. Dev., 2012, 16(5), 1090-1097

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Process intensification for the continuous flow hydrogenation of ethyl nicotinate

Ouchi, T.; Battilocchio, C.; Hawkins, J. M.; Ley, S. V.; Org. Process Res. Dev., 2014, 18(11), 1560-1566

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Process intensification of ozonolysis reactions using dedicated microstructured reactors

Polterauer, D. et al.; React. Chem. Eng., 2021, 6, 2253-2258

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Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors

George, D. M.; Huntley, R. J.; Cusack, K.; Duignan, D. B.; Hoemann, M.; Loud, J.; Mario, R.; Melim, T.; Mullen, K.; Somal, G.; Wang, L.; Edmunds, J. J.; PlosOne, 2018, online article

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Protecting group principles suited to late stage functionalization and global deprotection in oligosaccharide synthesis

Dhara, D. et al.; Carbohydrate Research, 2022, 521, 108644

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Pt-cinchonidine catalyzed asymmetric catalytic cascade reaction of 2-nitrophenylpyruvates in flow system

Kovacs, L.; Szollosi, Gy.; Fulop, F.; J. Flow Chem., 2015, 5(4), 210-215

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Pyrazole and imidazo[1,2-b]pyrazole Derivatives as New Potential Anti-tuberculosis Agents

Meta, E. et al.; Med. Chem., 2019, 15(1), 17-27

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Pyrido[2,3-d]pyrimidin-5-ones: A novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors

Huang, H.; Hutta, D. A.; Rinker, J. M.; Hu, H.; Parsons, W. H.; Schubert, C.; DesJarlais, R. L.; Crysler, C. S.; Chaikin, M. A.; Donatelli, R. R.; Chen, Y.; Cheng, D.; Zhou, Z.; Yurkow, E.; Manthey, C. L.; Player, M. R.; J. Med. Chem., 2009, 52(4), 1081-1099

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Pyrrolizidine alkaloids: occurrence, biology, and chemical synthesis

Stevens, K. et al.; Nat. Prod. Rep., 2017, 34, 62-89

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Quantification of benzoxazinoids and their metabolites in Nordic breads

Dihm, K. et al.; Food Chemistry, 2017, 235, 7-13

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Quinazolinones, Quinazolinthiones, and Quinazolinimines as Nitric Oxide Synthase Inhibitors: Synthetic Study and Biological Evaluation

Camacho, M. E. et al.; Arch. Pharm. Chem. Life Sci., 2016, 349, 638-650

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Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines

Labes, R. et al.; Synlett, 2017, 28(20), 2855-2858

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Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform

Desai, B.; Dixon, K.; Farrant, E.; Feng, Q.; Gibson, K. R.; van Hoorn, W. P.; Mills, J.; Morgan, T.; Parry, D. M.; Ramjee, M. K.; Selway, C. N.; Tarver, G. J.; Whitlock, G.; Wright, A. G.; J. Med. Chem., 2013, 56(7), 3033-3047

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Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

Liang, S. H.; Collier, T. L.; Rotstein, B. H.; Lewis, R.; Steck, M.; Vasdev, N.; Chem. Commun., 2013, 49(78), 8755-8757

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Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry

Ekholm, F. S.; Mandity, I. M.; Fulop, F.; Leino, R.; Tetrahedron Lett., 2011, 52, 1839-1841

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Rapid synthesis of substituted pyrrolines and pyrrolidines by nucleophilic ring closure at activated oximes

Chandan, N.; Thompson, A. L.; Moloney, M. G.; Org. Biomol. Chem., 2012, 10, 7863-7868

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Reaction screening in continuous flow reactors

Mohamed, D. K. B.; Yu, X.; Li, J.; Wu, J.; Reaction screening in continuous flow reactors; Tetrahedron Lett., 2016, 57, 3965-3977.

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ReactIR flow cell: a new analytical tool for continuous flow chemical processing

Carter, C. F.; Lange, H.; Ley, S. V.; Baxendale, I. R.; Wittkamp, B.; Goode, J. G.; Gaunt, N. L.; Org. Process Res. Dev., 2010, 14, 393-404

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Reactivation of catalysts for methanol-to-hydrocarbons conversion with hydrogen

Paunovic, V. et al.; Journal of Catalysis, 2022, 407, 54-64

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Reagent-controlled stereoselective synthesis of (±)-gallo- and (±)-epigallo-catechin gallates

Tanaka, H.; Chino, A.; Takahashi, T.; Tetrahedron Letters, 2012, 53, 2493-2495

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Rearrangement of N-alkyl 1,2-amino alcohols. Synthesis of (S)-toliprolol and (S)-propanolol

Duthion, B.; Metro, T.; Padro, D. G.; Cossy, J.; Tetrahedron, 2009, 65(33), 6696-6706

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Recent advances for serial processes of hazardous chemicals in fully integrated microfluidic systems

Singh, R.; Lee, H. J.; Singh, A. K.; Kim, D. P.; Korean Journal of Chemical Engineering, 2016, 33(8), 2253-2267

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Recent advances in asymmetric catalysis in flow

Zhao, D.; Ding, K.; ACS Catal., 2013, 3(5), 928-944

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Recent advances in micro reaction technology

Wiles, C.; Watts, P.; Chemical Communications, 2011, 47(23), 6512-6535

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Recent Development of Palladium-Supported Catalysts for Chemoselective Hydrogenation

Monguchi, Y. et al.; Chem. Pharm. Bull., 2017, 65, 2-9

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Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules

Kopf, S. et al.; Chem. Rev., 2022, 122, 6634-6718

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Recent Progress in Continuous-Flow Hydrogenation

Yu, T. et al.; ChemSusChem, 2020, 13(11), 2876-2893

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Reconstruction of humins formation mechanism from decomposition products: A GC-MS study based on catalytic continuous flow depolymerizations

Filiciotto, L.; M. Balu, A.; Romero, A. A.; Angelici, C.; van der Waal, J. C.; Luque, R.; Mol. Cat., 2019, 479, 110564

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Recoverable and Reusable Polymer Microbead-Supported Metal Nanocatalysts for Redox Chemical Transformations

Fernandes, A. B. et al.; ACS Appl. Nano Mater., 2020, 3, 1722-1730

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Recycling the waste: the development of a catalytic Wittig reaction

O'Brien, C. J.; Tellez, J. L.; Nixon, Z. S.; Kang, L. J.; Carter, A. L.; Kunkel, S. R.; Przeworski, K. C.; Chass, G. A.; Angew. Chem. Int. Ed., 2009, 48(37), 6836-6839

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Reducing Challenges in Organic Synthesis with Stereoselective Hydrogenation and Tandem Catalysis

Parker, P. D. et al.; JACS, 2021, 143(18), 6724-6745

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Reductive amination in the synthesis of pharmaceuticals

Afanasyev, O. I.; Kuchuk, E.; Usanov, D. L.; Chusov, D.; Chem. Rev., 2019, 119(23), 11857-11911

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Reductive amination by continuous-flow hydrogenation: direct and scalable synthesis of a benzylpiperazine

Liu, J.; Fitzgerald, A. E.; Mani, N. S.; Synthesis, 2012, 44(15), 2469-2473

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Reductive amination of 5-acetoxymethylfurfural over Pt/Al2O3 catalyst in a flow reactor

Nuzhdin, A. L. et al.; Mol. Cat., 2021, 499, 111297

Link to article

Reductive Amination of 5-Hydroxymethylfurfural by the Hydrogenation of Intermediate Imines in the Presence of a Pt/Al2O3 Catalyst in a Flow Reactor

Nuzhdin, A. L. et al.; Kinetics and Catalysis, 2021, 62, 507-512

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Reductive amination of ketones: novel one-step transfer hydrogenations in batch and continuous-flow mode

Falus, P.; Boros, Z.; Hornyanszky, G.; Nagy, J.; Darvas, F.; Urge, L.; Poppe, L.; Tetrahedron Letters, 2011, 52, 1310-1312

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Regio-, diastereo-, and enantioselective nitroso-Diels–Alder reaction of 1,3-diene-1-carbamates catalyzed by chiral phosphoric acids

Pous, J.; Courant, T.; Bernadat, G.; Iorga, B. I.; Blanchard, F.; Masson, G.; J. Am. Chem. Soc., 2015, 137(37), 11950-11953

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Regioselective catalytic alkylation of N-heterocycles in continuous flow

Sipocz, T.; Lengyel., L.; Sipos, G.; Kocsis, L.; Dorman, Gy.; Jones, R. V.; Darvas, F.; J. Flow Chem., 2016, 6(2), 117-122

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Reissert indole synthesis using continuous-flow hydrogenation

Colombo, E.; Ratel, P.; Mounier, L.; Guillier, F.; J. Flow Chem., 2011, 2, 68-73

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Reversal of the ee in enantioselective hydrogenation of activated ketones in continuous-flow fixed-bed reactor system

Cserenyi, Sz.; Szollosi, Gy.; Szori, K.; Fulop, F.; Bartok, M.; Catalysis Communications, 2010, 12, 14-19

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Reversible and efficient inhibition of UDP‐galactopyranose mutase by electrophilic, constrained and unsaturated UDP‐galactitol analogues

Ansiaux, C.; N'Go, I.; Vincent, S. P.; Chem. Eur. J., 2012, 18(46), 14860-14866

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Revisiting the deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions

Tshibalonza, N. N.; Monbaliu, J-C. M.; Green Chem., 2017, 19, 3006-3013

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Ruthenium and osmium complexes of novel carbohydrate derived salen ligands: Synthesis, characterization and in situ ligand reduction

Mandal, S.; Mandal, S.; Seth, D. K.; Mukhopadhyay, B.; Gupta, P.; Inorganica Chimica Acta, 2013, 398, 83-88

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Safe generation and synthetic utilization of hydrazoic acid in a continuous flow reactor

Gutmann, B.; Obermayer, D.; Roduit, J. P.; Roberge, D. M.; Kappe, C. O.; J. Flow Chem., 2012, 2(1), 8-19

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Safe hydrogenation of organic compounds and their property studies

Soung, M. J.; Woo, S. J.; Shin, D. J.; APEC Youth Scientist Journal, 2015, 7(1), 45-53

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Structure-activity relationship studies of mitogen activated protein kinase interacting kinase (MNK) 1 and 2 and BCR-ABL1 inhibitors targeting chronic myeloid leukemic cells

Cherian, J.; Nacro, K.; Poh, Z. Y.; Guo, S.; Jeyaray, D. A.; Wong, Y. X.; Ho, M.; Yang, H. Y.; Joy, J. K.; Kwek, Z. P.; Liu, B.; Wee, J. L. K.; Ong, E. H.; Choong, M. L.; Poulsen, A.; Lee, M. A.; Pendharkar, V.; Ding, L. J.; Manoharan, V.; Chew, Y. S.; Sangthongpitag, K.; Lim, S.; Ong, S. T.; Hill, J.; Keller, T. H.; J. Med. Chem., 2016, 59(7), 3063-3078

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SBA materials as support of iridium catalyst for hydrogenation reactions

Kiderys, A.; Kot, M.; Janiszewska, E.; Pietrowski, M.; Yang, C-M.; Zielinski, M.; Catalysis Today, 2019, accepted manuscript

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Scalable and robust photochemical flow process towards small spherical gold nanoparticles

Bianchi, P. et al.; React. Chem. Eng., 2020, 5, 1224-1236

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Scalable and straightforward synthesis of all isomeric (cyclo)alkylpiperidines

Subota, A. I.; Lutsenko, A. O.; Vashchenko, B. V.; Volochnyuk, D. M.; Levchenko, V.; Dmytriv, Y. V.; Rusanov, E. B.; Gorlova, A. O.; Ryabukhin, S. V.; Grygorenko, O. O.; Eur. J. Org. Chem., 2019, 2019(22), 3636-3648

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Scalable continuous flow hydrogenations using Pd/Al2O3-coated rectangular cross-section 3D-printed static mixers

Lebl, R. et al.; Catalysis Today, 2022, 383, 55-63

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Scalable synthesis of an integrin-binding peptide mimetic for biomedical applications

Riches, A. G.; Cablewski, T.; Glattauer, V.; Thissen, H.; Meagher, L.; Tetrahedron, 2012, 68(46), 9448-9455

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Scale-up of flow-assisted synthesis of C2-symmetric chiral PyBox ligands

Battilocchio, C.; Baumann, M.; Baxendale, I. R.; Biava, M.; Kitching, M. O.; Ley, S. V.; Martin, R. E.; Ohnmacht, S. A.; Tappin, N. D. C.; Synthesis, 2012, 4, 635-647

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Scale-up synthesis of a deuterium-labeled cis-cyclobutane-1,3-dicarboxylic acid derivative using continuous photo flow chemistry

Yamashita, T.; Nishikawa, H.; Kawamoto, T.; Tetrahedron, 2019, 75(5), 617-623

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Scaling up and validation of hydrogenation reactions using a continuous-flow microfluidics-based reactor, H-Cube®

Spadoni, C; Jones, R. V.; Urge, L.; Darvas, F.; Chemistry Today, 2006, January/February 2006, 38-41

Scouting in silico different chemo-types of PDE4 inhibitors to guide the design of new anti-inflammatory/antioxidant agents

Cichero, E. et al.; ChemMedChem, 2023, Accepted manuscript

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Scrap waste automotive converters as efficient catalysts for the continuous-flow hydrogenations of biomass derived chemicals

Cova, C. M.; Zuliani, A.; Manno, R.; Sebastian, V.; Luque, R.; Green Chemistry, 2020, 22, 1414-1423

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Selective catalytic hydrogenations in a microfluidics-based high throughput flow reactor on ion-exchange supported transition metal complexes: A modular approach to the heterogenization of soluble complex catalysts

Horvath, H. H.; Papp, G.; Csajagi, Cs.; Joo, F.; Cat. Commun., 2007, 8, 442-446

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Selective continuous flow phenylacetylene hydrogenation over Pd-biogenic calcium carbonate

Chaparro, S. et al.; Catalysis Today, 2021, 368, 181-186

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Selective ensembles in supported palladium sulfide nanoparticles for alkyne semi-hydrogenation

Albani, D.; Shahrokhi, M.; Chen, Z.; Mitchell, S.; Hauert, R.; Lopez, N.; Perez-Ramirez, J.; Nature Communications, 2018, 9, article number: 2634

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Selective hydrodeoxygenation of acetophenone derivatives using a Fe25Ru75@SILP catalyst: a practical approach to the synthesis of alkyl phenols and anilines

Goclik, L. et al.; Green Chemistry, 2022, 24, 2937-2945

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Selective Hydrogenation of 5-Acetoxymethylfurfural over Cu-Based Catalysts in a Flow Reactor: Effect of Cu-Al Layered Double Hydroxides Synthesis Conditions on Catalytic Properties

Bukhtiyarova, M. V. et al.; Catalysts, 2022, 12, 878

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Selective Hydrogenation of Benzofurans Using Ruthenium Nanoparticles in Lewis Acid-Modified Ruthenium-Supported Ionic Liquid Phases

El Sayed, S. et al.; ACS Catal., 2020, 10(3), 2124-2130

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Selective hydrogenation of furfural using TiO2-Fe2O3/C from Ti-Fe-MOFs as sacrificial template: Microwave vs Continuous flow experiments

Ronda-Leal, M. et al.; Fuel, 2023, 333, 126221

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Selective liquid‐phase hydrogenation of a nitro group in substituted nitrobenzenes over Au/Al2O3 catalyst in a packed‐bed flow reactor

Nuzhdin, A. L.; Moroz, B. L.; Bukhtiyarova, G. A.; Reshetnikov, S. I.; Pyrjaev, P. A.; Aleksandrov P. V.; Bukhtiyarov, V. I.; ChemPlusChem, 2015, 80(12), 1741-1749

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Self-assembly of a helical zinc-europium complex: speciation in aqueous solution and luminescence

Deiters, E.; Eliseeva, S. V.; Bunzli, J. C. G.; Front. Chem., 2013, 1(15), 1-14

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Self-optimizing reactor systems: Algorithms, on‐line analytics, setups, and strategies for accelerating continuous flow process optimization

Fabry, D. C.; Sugiono, E.; Ruepig, M.; Isr. J. Chem., 2014, 54(4), 341-350

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Sequential nitration/hydrogenation protocol for the synthesis of triaminophloroglucinol: Safe generation and use of an explosive intermediate under continuous-flow conditions

Cantillo, D.; Damm, M.; Dallinger, D.; Bauser, M.; Berger, M.; Kappe, C. O.; Org. Process Res. Dev., 2014, 18(11), 1360-1366

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Short Total Synthesis of (±)-γ-Lycorane by a Sequential Intramolecular Acylal Cyclisation (IAC) and Intramolecular Heck Addition Reaction

Monaco, A. et al.; Chem. Eur. J., 2017, 23, 4750-4755

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SiliaCat: A versatile catalyst series for synthetic organic chemistry

Ciriminna, R.; Pandarus, V.; Fidalgo, A.; Ilharco, L. M.; Beland, F.; Pagliaro, M.; Org. Process Res. Dev., 2015, 19(7), 755-768

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Silica-Immobilized NHC-Gold(I) Complexes: Versatile Catalysts for the Functionalization of Alkynes under Batch and Continuous Flow Conditions

Sarmiento, J. T. et al.; ACS Catal., 2017, 7(10), 7146-7155

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Silica-Supported 1st Row Transition Metal (Nano)Catalysts: Synthetic and Catalytic Insight

Reina, A. et al.; ChemCatChem, 2023, 15(11), e202300285

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Simplifying levulinic acid conversion towards a sustainable biomass valorisation

Defilippi, C. et al.; Green Chemistry, 2020, 22, 2929-2934

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Single-atom heterogeneous catalysts based on distinct carbon nitride scaffolds

Chen, Z.; Vorobyeva, E.; Mitchell, S.; Fako, E.; Lopez, N.; Collins, S. M.; Leary, R. K.; Midgley, P. A.; Hauert, R.; Perez-Ramirez, J.; National Science Review, 2018, 5(5), 642-652

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Single operation stereoselective synthesis of Aerangis lactones: Combining continuous flow hydrogenation and biocatalysts in a chemoenzymatic sequence

Fink, M. J.; Schon, M.; Rudroff, F.; Schnurch, M.; Mihovilovic, M. D.; ChemCatChem, 2013, 5, 724-727

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Site‐selective deuterated‐alkene synthesis with palladium on boron nitride

Yabe, Y.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Chem. Eur. J., 2013, 19, 484-488

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Small-Molecule Inhibitors of the NusB−NusE Protein−Protein Interaction with Antibiotic Activity

Cossar, P. J. et al.; ACS Omega, 2017, 2, 3839-3857

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Solvent-free continuous operations using small footprint reactors: A key approach for process intensification

Ouchi, T.; Mutton, R. J.; Rojas, V.; Fitzpatrick, D. E.; Cork, D. G.; Battilocchio, C.; Ley, S. V.; ACS Sustainable Chem. Eng., 2016, 4, 1912-1916

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Solvent-free enzymatic process for biolubricant production in continuous microfluidic reactor

Madarasz, J.; Nemeth, D.; Bakos, J.; Gubicza, L.; Bakonyi, P.; Journal of Cleaner Production, 2015, 93, 140-144

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Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control

Voltrova, S.; Srogl, J.; Org. Chem. Front., 2014, 1, 1067-1071

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Spirocyclic dihydropyridines by electrophile-induced dearomatizing cyclization of N-alkenyl pyridinecarboxamides

Senczyszyn, J.; Brice, H.; Clayden, J.; Org. Lett., 2013, 15(8), 1922-1925

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Stabilization of Single Metal Atoms on Graphitic Carbon Nitride

Chen, Z. et al.; Adv. Funct. Mater., 2017, 27, 1605785

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Stepwise aromatic nucleophilic substitution in continuous flow. Synthesis of an unsymmetrically substituted 3,5-diamino-benzonitrile library

Lengyel, L.; Gyollai, V.; Nagy, T.; Dorman, G.; Terleczky, P.; Hada, V.; Nogradi, K.; Sebok, F.; Urge, L.; Darvas, F.; Mol. Divers., 2011, 15(3), 631-638

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Stereo‐ and chemoselective character of supported CeO2 catalysts for continuous‐flow three‐phase alkyne hydrogenation

Vile, G.; Wrabetz, S.; Floryan, L.; Schuster, M. E.; Girgsdies, F.; Teschner, D.; Perez-Ramirez, J.; ChemCatChem, 2014, 6(7), 1928-1934

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Stereocontrolled synthesis of the cis‐hydroxydecalin system: Towards biologically active 19‐nor‐clerodanes

Mirzayans, P. M.; Pouwer, R. H.; Williams, C. M.; Bernhardt, P. V.; Eur. J. Org. Chem., 2012, 2012(8), 1633-1638

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Stereoselective approaches to 2,3,6-trisubstituted piperidines. An enantiospecific synthesis of quinolizidine (−)-217A

Mancey, N. C.; Sandon, N.; Auvinet, A. L.; Butlin, R. J.; Czechtizky, W.; Harrity, J. P. A.; Chem. Commun., 2011, 47(35), 9804-9806

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Stereoselective catalytic synthesis of active pharmaceutical ingredients in homemade 3D‐printed mesoreactors

Rossi, S.; Porta, R.; Brenna, D.; Puglisi, A.; Benaglia, M.; Angew. Chem. Int. Ed., 2017, 56(15), 4290-4294

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Stereoselective metal‐free reduction of chiral imines in batch and flow mode: a convenient strategy for the synthesis of chiral active pharmaceutical ingredients

Brenna, D.; Benaglia, M.; Porta, R.; Fernandes, S.; Burke, A. J.; Eur. J. Org. Chem., 2017, 2017(1), 39-44

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Stereoselective reduction of prochiral cyclic 1,3-diketones using different biocatalysts

Contente, M. L.; Dall’Oglio, F.; Annunziata, F.; Molinari, F.; Rabuffetti, M.; Romano, D.; Tamborini, L.; Rother, D.; Pinto, A.; Catalysis Letters, 2019, accepted manuscript

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Stereoselective syntheses and transformations of chiral 1,3-aminoalcohols and 1,3-diols derived from nopinone

Szakonyi, Zs.; Gonda, T.; Otvos, S. B.; Fulop, F.; Tetrahedron: Asymmetry, 2014, 25, 1138-1145

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Stereoselective total synthesis of the marine macrolide sanctolide A

Yadav, J. S.; Suresh, B.; Srihari, P.; Eur. J. Org. Chem., 2015, 2015(26), 5856-5863

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Straightforward hetero Diels-Alder reactions of nitroso dienophiles by microreactor technology

Monbaliu, J-C. M. R.; Cukalovic, A.; Marchand-Brynaert, J.; Stevens, C. V.; Tetrahedron Letters, 2010, 51, 5830-5833

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Structural assessment of novel spiro-naphthalene-1.2′- [1,3,4]oxadiazol-4-ones prepared under batch and flow chemistry with a concise antifungal and anti(myco)bacterial activity

Saleh, L. Y. et al.; Tetrahedron, 2023, 131, 133231

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Structural Effects of Metal Single-Atom Catalysts for Enhanced Photocatalytic Degradation of Gemfibrozil

Ruta, V. et al.; ACS Appl. Nano Mater., 2022, 5, 14520-14528

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Structural identification of petroleum acids by conversion to hydrocarbons and multidimensional gas chromatography-mass spectrometry

Wilde, M. J.; Rowland S. J.; Analytical Chemistry, 2015, 87(16), 8457-8465

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Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives

Bazin, H. G.; Li, Y.; Khalaf, J. K.; Mwakwari, S.; Livesay, M. T.; Evans, J. T.; Johnson, D. A.; Bioorg. Med. Chem. Lett., 2015, 25(6), 1318-1323

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Structural studies of the O-acetyl-containing O-antigen from a Shigella flexneri serotype 6 strain and synthesis of oligosaccharide fragments thereof

Chassagne, P.; Fontana, C.; Guerreiro, C.; Gauthier, C.; Phalipon, A; Widmalm, G.; Mulard, L. A.; Eur. J. Org. Chem., 2013, 2013(19), 4085-4106

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Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening

Ancellin, N. et al.; J. Med. Chem., 2016, 59, 2452-2467

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Structure–Activity Relationship Study of the High-Affinity Neuropeptide Y4 Receptor Positive Allosteric Modulator VU0506013

Schüß, C. et al.; J. Med. Chem., 2023, 66(13), 8745–8766

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Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents

Ng, P. S.; Manjunatha, U. H.; Rao, S. P. S.; Camacho, L. R.; Ma, N. L.; Herve, M.; Noble, C. G.; Goh, A.; Peukert, S.; Diagana, T. T.; Smith, P. W.; Kondreddi, R. R.; Eur. J. Med. Chem., 2015, 106, 144-156

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Structure and reactivity of supported hybrid platinum nanoparticles for the flow hydrogenation of functionalized nitroaromatics

Vile, G.; Almora-Barrios, N.; Lopez, N.; Perez-Ramirez, J.; ACS Catal., 2015, 5(6), 3767-3778

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Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase

Nichols, D. A.; Jaishankar, P.; Larson, W.; Smith, E.; Liu, G.; Beyrouthy, R.; Bonnet, R.; Renslo, A. R.; Chen, Y.; J. Med. Chem., 2012, 55(5), 2163-2172

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Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine

Bucknell, S. J. et al.; J. Med. Chem., 2020, 63(14), 7906-7920

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Structure-based optimization of naphthyridones into potent ATAD2 bromodomain inhibitors

Bamborough, P.; Chung, C.; Furze, R. C.; Grandi, P.; Michon, A.; Sheppard, R. J.; Barnett, H.; Diallo, H.; Dixon, D. P.; Douault, C.; Jones, E. J.; Karamshi, B.; Mitchell, D. J.; Prinjha, R. K.; Rau, C.; Watson, R. J.; Werner, T.; Demont, E. H.; J. Med. Chem., 2015, 58(15), 6151-6178

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Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential

Coteron, J. M.; Marco, M.; Esquivias, J.; Deng, X.; White, K. L; White, J.; Koltun, M.; Mazouni, F. E.; Kokkonda, S.; Katneni, K.; Bhamidipati, R.; Shackleford, D. M.; Angulo-Barturen, I.; Ferrer, S. B.; Jimenez-Diaz, M. B.; Gamo, F. J.; Goldasmith, E. J.; Charman, W. N.; Bathurst, I.; Floyd, D.; Matthews, D.; Burrows, J. N.; Rathod, P. K.; Charman, S. A.; Philips, M. A; J. Med. Chem., 2011, 54(15), 5540-5561

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Structuring hybrid palladium nanoparticles in metallic monolithic reactors for continuous-flow three-phase alkyne hydrogenation

Albani, D.; Vile, G.; Toro, M. A. B.; Kaufmann, R.; Mitchell, S.; Perez-Ramirez, J.; React. Chem. Eng., 2016, 1, 454-462

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Studies of long chain lipids in insects by high temperature gas chromatography and high temperature gas chromatography–mass spectrometry

Sutton, P. A.; Wilde, M. J.; Martin, S. J.; Cvacka, J.; Vrkoslav, V.; Rowland, S. J.; Journal of Chromatography A, 2013, 1297, 236-240

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Studies on the continuous-flow synthesis of nonpeptidal bis-tetrahydrofuran moiety of Darunavir

Leao, R. A. C.; Lopes, R. de O.; de M. Bezerra, M. A.; Muniz, M. N.; Casanova, B. B.; Gnoatto, S. C. B.; Gosmann, G.; Kocsis, L.; de Souza, R. O. M. A.; de M. Miranda, L. S.; Journal of Flow Chemistry, 2015, 5(4), 216-219

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Studies on the synthesis of the lasubine alkaloids

Aslam, N. F. M.; Simon, O.; Bates, R. W.; Tetrahedron, 2018, 74(38), 5032-5039

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Study of Catalyst Deactivation in Liquid-Phase Hydrogenation of 3-Nitrostyrene Over Au/Al2O3 Catalyst in Flow Reactor

Reshetnikov, S. I. et al.; Catal. Lett., 2017, 147, 572-580

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Substrate engineering: Effects of different N-protecting groups in the CAL-B-catalysed asymmetric O-acylation of 1-hydroxymethyl-tetrahydro-β-carbolines

Megyesi, R.; Forro, E.; Fulop, F.; Tetrahedron, 2018, 74(21), 2634-2640

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Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer’s Disease

Rossi, M. et al.; J. Med. Chem., 2021, 64(8), 4972-4990

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Sustainable flow approaches to active pharmaceutical ingredients

Ferlin, F. et al.; Green Chemistry, 2020, 22, 5937-5955

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Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4

Brown, A. W. et al.; J. Med. Chem., 2016, 59, 9473-9488

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Synergistic interaction within bifunctional ruthenium nanoparticle/SILP catalysts for the selective hydrodeoxygenation of phenols

Luska, K. L.; Migowski, P.; El Sayed, S.; Leitner, W.; Angew. Chem., 2015, 127(52), 15976-15981

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Syntheses and Reactions of Pyrroline, Piperidine Nitroxide Phosphonates

Isbera, M. et al.; Molecules, 2020, 25, 2430

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Syntheses of 4-, 5-, 6-, and 7-substituted tryptamine derivatives and the use of a bromine atom as a protecting group

Rene, O.; Fauber, B. P.; Tetrahedron Letters, 2014, 55(4), 830-833

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Syntheses of four enantiomers of 2,3-diendo- and 3-endo-aminobicyclo[2.2.2]oct-5-ene-2-exo-carboxylic acid and their saturated analogues

Palko, M.; Hanninen, M. M.; Sillanpaa, R.; Fulop, F.; Molecules, 2013, 18(12), 15080-15093

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Synthesis and activity of putative small-molecule inhibitors of the F-Box protein SKP2

Shouksmith, A. E.; Evans, L. E.; Tweddle, D. A.; Miller, D. C.; Willmore, E.; Newell, D. R.; Golding, B. T.; Griffin, R. J.; Aust. J. Chem., 2015, 68(4), 660-679

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Synthesis and anticancer activity of a series of norcantharidin analogues

Tarleton, M.; Gilbert, J.; Sakoff, J. A.; McCluskey, A.; Eur. J. Med. Chem., 2012, 54, 573-581

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Synthesis and Antimicrobial Studies of New Spiropyran Quinazolinone Derivatives with Amide, Urea, and Sulfonamide Moieties

Poojari, S. et al.; J. Heterocyclic Chem., 2017, 54(6), 3527-3537

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Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease

Alexandre, F-R.; Brandt, G.; Caillet, C.; Chaves, D.; Convard, T.; Derock, M.; Gloux, D.; Griffon, Y.; Lallos, L.; Leroy, F.; Liuzzi, M.; Loi, A-G.; Moulat, L.; Musiu, C.; Parsy, C.; Rahali, H.; Roques, V.; Seifer, M.; Standring, D.; Surleraux, D.; Bioorg. Med. Chem. Lett., 2015, 25(18), 3984-3991

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Synthesis and arylation of unprotected sulfonimidamides

Maldonado; M. F.; Sehgelmeble, F.; Bjarnemark, F.; Svensson, M.; Ahman, F.; Arvidsson, P. I.; Tetrahedron, 2012, 68, 7456-7462

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Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins

McCarthy, A. R.; Pirrie, L.; Hollick, J. J.; Ronseaux, S.; Campbell, J.; Higgins, M.; Staples, O. D.; Tran, F.; Slawin, A. M. Z.; Lain, S.; Westwood, N. J.; Bioorg. Med. Chem., 2012, 20, 1779-1793

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Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

Spencer, J.; Rathnam, R. P.; Harvey, A. L.; Clements, C. J.; Clark, R. L.; Barrett, M. P.; Wong, P. E.; Male, L.; Coles, S. J.; Mackay, S. P.; Bioorg. Med. Chem., 2011, 19, 1802-1815

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Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents

Marhadour, S.; Marchand, P.; Pagniez, F.; Bazin, M. A.; Picot, C.; Lozach, O.; Ruchaud, S.; Antoine, M.; Meijer, L.; Rachidi, N.; Le Pape, P.; Eur. J. Med. Chem., 2012, 58, 543-556

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Synthesis and biological evaluation of an orally active glycosylated endomorphin-1

Varamini, P.; Mansfeld, F. M.; Blanchfield, J. T.; Wyse, B. D.; Smith, M. T.; Toth, I.; J. Med. Chem., 2012, 55(12), 5859-5867

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Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting αvβ3/αvβ5 integrins and IAP proteins

Mingozzi, M.; Manzoni, L.; Arosio, D.; Dal Corso, A.; Manzotti, M.; Innamorati, F.; Pignataro, L.; Lecis, D.; Delia, D.; Seneci, P.; Gennari, C.; Org. Biomol. Chem., 2014, 12, 3288-3302

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Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists

Batie, S.; Lee, J. H.; Jama, R. A:; Browder, D. O.; Montano, L. A.; Huynh, C. C.; Marcus, L. M.; Tsosie, D. G.; Mohammed, Z.; Trang, V.; Marshall, P. A.; Jurutka, P. W.; Wagner, C. E.; Bioorg. Med. Chem., 2013, 21, 693-702

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Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Lawrence, H. R.; Kazi, A.; Luo, Y.; Kendig, R.; Ge, Y.; Jain, S.; Daniel, K.; Santiago, D.; Guida, W. C.; Sebti, S. M.; Bioorg. Med. Chem., 2010, 18(15), 5576-5592

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Synthesis and biological evaluation of second-generation tropanol-based androgen receptor modulators

Sunden, H.; Holland, M. C.; Poutiainen, P. K.; Jaaskelainen, T.; Pulkkinen, J. T.; Palvimo, J. J.; Olsson, R.; J. Med. Chem., 2015, 58, 1569-1574

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Synthesis and Characterization of Late Transition Metal Complexes of Mono-Acetate Pendant Armed Ethylene Cross-Bridged Tetraazamacrocycles with Promise as Oxidation Catalysts for Dye Bleaching

Hoang, T. et al.; Molecules, 2023, 28(1), 232

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Synthesis and cytotoxicity of octahydroepoxyisoindole-7-carboxylic acids and norcantharidin-amide hybrids as norcantharidin analogues

Hizartzidis, L.; Gilbert, J.; Gordon, C. P.; Sakoff, J. A.; McCluskey, A.; ChemMedChem, 2019, 14(12), 1152-1161

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Synthesis and pharmacological activity of the epimers of hexahydrocannabinol (HHC)

Russo, F. et al.; Sci. Rep., 2023, 13, 11061

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Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators

Ostacolo, C. et al.; J. Med. Chem., 2020, 63(1), 163-185

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Synthesis and photophysical characterization of 1- and 4-(purinyl)triazoles

Redwan, I. N.; Bliman, D.; Tokugawa, M.; Lawson, C.; Grotli, M.; Tetrahedron, 2013, 69(42), 8857-8864

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Synthesis and reactivity of 3-amino-1H-pyrazolo[4,3-c]pyridin-4(5H)-ones: development of a novel kinase-focussed library

Smyth, L. A.; Matthews, T. P.; Horton, P. N.; Hursthouse, M. B.; Collins, I.; Tetrahedron, 2010, 66, 2843-2854

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Synthesis and reactivity of new amide-substituted oxindole derivatives

Ignatov, A. A. et al.; Tetrahedron, 2017, 73, 6887-6893

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Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries

Spencer, J.; Patel, H.; Callear, S. K.; Coles, S. J.; Deadman, J. J.; Tetrahedron Letters, 2011, 52, 5905-5909

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Synthesis and Structural Elucidation of 1,2-Disubstituted 3-Fluoropiperidines

Fischer, P. et al.; Eur. J. Org. Chem., 2020, 2020(9), 1165-1176

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Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase

Christoff, R. M. et al.; Bioorg. Med. Chem., 2021, 52, 116518

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Synthesis and structure–activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase

Luci, D. K.; Jameson, J. B.; Yasgar, A.; Diaz, G.; Joshi, N.; Kantz, A.; Markham, K., Perry, S.; Kuhn, N.; Yeung, J., Kerns, E. H.; Schultz, L.; Holinstat, M.; Nadler, J. L.; Taylor-Fishwick, D. A.; Jadhav, A.; Simeonov, A.; Holman, T. R.; Maloney, D. J.; J. Med. Chem., 2014, 57(2), 495-506

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Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer

Dexheimer, T. S.; Rosenthal, A. S.; Luci, D. K.; Liang, Q.; Villamil, M. A.; Chen, J.; Sun, H.; Kerns, E. H.; Simeonov, A.; Jadhav, a.; Zhuang, Z.; Maloney, D. J.; J. Med. Chem., 2014, 57(19), 8099-8110

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Synthesis and structure–activity relationships of N‐(4‐benzamidino)‐oxazolidinones–potent and selective inhibitors of kallikrein‐related peptidase 6

De Vita, E.; Smits, N.; van den Hurk, H.; Beck, E. M.; Hewitt, J.; Baillie, G.; Russell, E.; Pannifer, A.; Hamon, V.; Morrison, A.; McElroy, S. P.; Jones, P.; Ignatenko, N.; Gunkel, N.; Miller, A. K.; ChemMedChem, 2019, accepted manuscript

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Synthesis and structure–activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors

Ponzano, S.; Bertozzi, F.; Mengatto, L.; Dionisi, M.; Armirotti, A.; Romeo, E.; Berteotti, A.; Fiorelli, C.; Tarozzo, G.; Reggiani, A.; Duranti, A.; Tarzia, G.; Mor, M.; Cavalli, A.; Piomelli, D.; Bandiera, T.; J. Med. Chem., 2013, 56(17), 6917-6934

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Synthesis, anti‐tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones

Leese, M. P.; Jourdan, F. L.; Major, M. R.; Dohle, W.; Thomas, M. P.; Hamel, E.; Ferrandis, E.; Mahon, M. F.; Newman, S. P.; Purohit, A.; Potter, B. V. L.; ChemMedChem, 2014, 9, 798-812

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Synthesis, antitubulin, and antiproliferative SAR of C3/C1‐substituted tetrahydroisoquinolines

Dohle, W.; Leese, M. P.; Jourdan, F. L.; Major, M. R.; Bai, R.; Hamel, E.; Ferrandis, E.; Kasprzyk, P. G.; Fiore, A.; Newman, S. P.; Purohit, A.; Potter, B. V. L.; ChemMedChem, 2014, 9, 350-370

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Synthesis, biological evaluation, and molecular modeling of new 3‑(cyclopentyloxy)-4-methoxybenzaldehyde O‑(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) related phosphodiesterase 4D (PDE4D) inhibitors

Brullo, C.; Massa, M.; Rocca, M; Rotolo, C.; Guariento, S.; Rivera, D.; Ricciarelli, R.; Fedele, E.; Fossa, P.; Bruno, O.; J. Med. Chem., 2014, 57(16), 7061-7072

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Synthesis, biological evaluation, and utility of fluorescent ligands targeting the μ-opioid receptor

Schembri, L. S.; Stoddart, L. A.; Briddon, S. J.; Kellam, B.; Canals, M.; Graham, B.; Scammells, P. J.; J. Med. Chem., 2015, 58(24), 9754-9767

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Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging

Andres, J. I.; Alcazar, J.; Cid, J. M.; De Angelis, M., Iturrino, L.; Langlois, X.; Lavreysen, H.; Trabanco, A. A.; Celen, S.; Bormans, G.; J. Med. Chem., 2012, 55, 8685-8699

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Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging

Andres, J-I.; De Angelis, M.; Alcazar, J.; Iturrino, L.; Langlois, X.; Dedeurwaerdere, S.; Lenaerts, I.; Vanhoof, G.; Celen, S.; Bormans, G.; J. Med. Chem., 2011, 54, 5820-5835

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Synthesis, Mesomorphism and the Optical Properties of Alkyl-Deuterated Nematogenic 4-[(2,6-Difluorophenyl)ethynyl]biphenyls

Herman, J. et al.; Materials, 2021, 14, 4653

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Synthesis of 12β-Methyl-18-nor-bile Acids

Luxenburger, A. et al.; ACS Omega, 2021, 6(38), 25019-25039

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Synthesis of 1,5-Anhydro-D-glycero-D-gluco-heptitol Derivatives as Potential Inhibitors of Bacterial Heptose Biosynthetic Pathways

Blaukopf, M. et al.; Synthesis, 2017, 49(24), 5320-5334

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Synthesis of 2,6-Dimethyltyrosine-Like Amino Acids through Pinacolinamide-Enabled C-H Dimethylation of 4-Dibenzylamino Phenylalanine

Illuminati, D. et al.; J. Org. Chem., 2022, 87, 5, 2580-2589

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Synthesis of 3-arylated 3,4-dihydrocoumarins: Combining continuous flow hydrogenation with laccase-catalysed oxidation

Suljic, S.; Pietruszka, J.; Adv. Synth. Catal., 2014, 356(5), 1007-1020

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Synthesis of 3-nitropyrrolidines via dipolar cycloaddition reactions using a modular flow reactor

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Synlett, 2010, 5, 749-752

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Synthesis of 3‐Hydroxypipecolic Acids

Cochi, A.; Pardo, D. G.; Cossy, J.; Eur. J. Org. Chem., 2013, 2013(5), 809-829

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Synthesis of 4-fluoromethylsydnones and their participation in alkyne cycloaddition reactions

Foster, R. S.; Adams, H.; Jakobi, H.; Harrity, J. P. A.; J. Org. Chem., 2013, 78(8), 4049-4064

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Synthesis of 5‐bromomethylfurfural from cellulose as a potential intermediate for biofuel

Kumari, N.; Olesen, J. K.; Pedersen, C. M.; Bols, M.; Eur. J. Org. Chem., 2011, 2011(7), 1266-1270

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Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state

Baltus, C. B.; Press, N. J.; Antonijevic, M. D.; Tizzard, G. J.; Coles, S. J.; Spencer, J.; Tetrahedron, 2012, 68(45), 9272-9277

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Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods

Baumann, M.; Baxendale, I. R.; Kuratli, C.; Ley, S. V.; Martin, R. E.; Schneider, J.; ACS Comb. Sci., 2011, 13(4), 405-413

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Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states

Dayde, B.; Benzaria, S.; Pierra, C.; Gosselin, G.; Surleraux, D.; Volle, J.; Pirat, J.; Virieux, D.; Org. Biomol. Chem, 2012, 10, 3448-3454

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Synthesis of a Nitroxide Spin-labeled Varenicline (Chantix) Derivative

Bognar, B. et al.; Org. Prep. and Proc. Int., 2021, 53(3), 311-315

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Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate

Howard, P. W.; Chen, Z.; Gregson, S. J.; Masterson, L. A.; Tiberghien, A. C.; Cooper, N.; Fang, M.; Coffils, M. J.; Klee, S.; Hartley, J. A.; Thurston, D. E.; Bioorg. Med. Chem. Lett. 2009, 19(22), 6463-6466

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Synthesis of a Pentasaccharide Fragment Related to the Inner Core Region of Rhizobial and Agrobacterial Lipopolysaccharides

Trattnig, N. et al.; J. Org. Chem., 2017, 82, 12346-12358

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Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki–Miyaura cross-couplings

Spencer, J.; Baltus, C. B.; Press, N. J.; Harrington, R. W.; Clegg, W.; Tetrahedron Letters, 2011, 52(31), 3963-3968

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Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope

Simerska, P.; Lu, H.; Toth, I.; Bioorg. Med. Chem. Lett., 2009, 19(3), 821-824

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Synthesis of a tetrasaccharide related to the triterpenoid saponin Bellisoside isolated from Bellis perennis (compositae)

Mandal, S.; Sharma, N.; Mukhopadhyay, B.; Tetrahedron: Asymmetry, 2010, 21, 2172-2176

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Synthesis of amines from alcohols in a nonepimerizing one-pot sequence – Synthesis of bioactive compounds: Cinacalcet and dexoxadrol

Guerin, C.; Bellosta, V.; Guillamot, G.; Cossy, J.; Eur. J. Org. Chem., 2012, 15, 2990-3000

Link to article

Synthesis of an azabicyclic framework towards (±)-actinophyllic acid

Mortimer, D.; Whiting, M.; Harrity, J. P. A.; Jones, S.; Coldham, I.; Tetrahedron Letters, 2014, 55, 1255-1257

Link to article

Synthesis of an undecasaccharide featuring an oligomannosidic heptasaccharide and a bacterial Kdo-lipid A backbone for eliciting neutralizing antibodies to mammalian oligomannose on the HIV-1 envelope spike

Trattnig, N.; Blaukopf, M.; Bruxelle, J-F.; Pantophlet, R.; Kosma, P.; JACS, 2019, 141(19), 7946-7954

Link to article

Synthesis of aromatic 13C/2H-α-ketoacid precursors to be used in selective phenylalanine and tyrosine protein labelling

Lichtenecker, R. J.; Org. Biomol. Chem., 2014, 12, 7551-7560

Link to article

Synthesis of benzannulated spiroketals using an oxidative radical cyclization

Sperry, J.; Liu, Y-C.; Wilson, Z. E.; Hubert, J. G.; Brimble, M. A.; Synthesis, 2011, 9, 1383-1398

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Synthesis of bioderived cinnolines and their flow-based conversion into 1,4-dihydrocinnoline derivatives

Devlin, J.; Clogher, R.; Baumann, M.; Synlett, 2019, accepted manuscript

Link to article

Synthesis of bivalent lactosides based on terephthalamide, N,N-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins

Leyden, R.; Velasco-Torrijos, T.; Andre, S.; Gouin, S.; Gabius, H-J.; Murphy, P. V.; J. Org. Chem., 2009, 74(23), 9010-9026

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Synthesis of Chalcones Derivatives and Their Biological Activities: A Review

Elkanzi, N. A. A. et al.; ACS Omega, 2022, 7, 27769-27786

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Synthesis of condensed heterocycles by the Gould-Jacobs reaction in a novel three-mode pyrolysis reactor

Lengyel, L. C.; Sipos, G.; Sipocz, T.; Vago, T.; Dorman, G.; Gerencser, J.; Makara, G.; Darvas, F.; Org. Process Res. Dev., 2015, 19(3), 399-409

Link to article

Synthesis of cross‐linked glycopeptides and ureas by a mechanochemical, solvent‐free reaction and determination of their structural properties by TEM and X‐ray crystallography

Kumar, V.; Giri, S. K.; Venugopalan, P.; Kartha, K. P. R.; ChemPlusChem, 2014, 79(11), 1605-1613

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Synthesis of four (4″-, 2″-, 2′-, and 6-) monodeoxy analogs of the trisaccharide α-d-Glcp-(1→3)-α-d-Manp-(1→2)-α-d-ManpOMe recognized by Calreticulin/Calnexin

Glinschert, A.; Oscarson, S.; Carbohydrate Research, 2015, 414, 65-71

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Synthesis of functionalized 3-hydroxypiperidines

Wijdeven, M. A.; van Delft, F. L.; Rutjes, F. P. J. T.; Tetrahedron, 2010, 66, 5623-5636

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Synthesis of Fused Pyrimidinone and Quinolone Derivatives in an Automated High Temperature and High Pressure Flow Reactor

Tsoung, J. et al.; J. Org. Chem., 2017, 82, 1073-1084

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Synthesis of Galactoacrylamide and Study of Stimuli-Responsive Fluorescent Hierarchical Self-Assembly-Promoted Specific Interactions with Proteins

Ajish, J. K. et al.; ChemistrySelect, 2023, 8(37), e202301497

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Synthesis of Highly Functionalized 4-Aminoquinolines

Wezeman, T. et al.; Angew. Chem. Int. Ed., 2016, 55, 3823-3827

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Synthesis of Highly Reactive Ketenimines via Photochemical Rearrangement of Isoxazoles

Bracken, C. et al.; Org. Lett., 2023, Accepted manuscript

Link to article

Synthesis of highly substituted nitropyrrolidines, nitropyrrolizines and nitropyrroles via multicomponent-multistep sequences within a flow reactor

Baumann, M.; Baxendale, I. R.; Kirschning, A.; Ley, S. V.; Wegner, J.; Heterocycles, 2011, 82(2), 1297-1316

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Synthesis of hydroxylated pyrrolidines by allenic cyclisation

Ng, P. S. et al.; Tetrahedron, 2016, 72, 6356-6362

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Synthesis of α-substituted vinylsulfonium salts and their application as annulation reagents in the formation of epoxide- and cyclopropane-fused heterocycles

Matlock, J. V.; Fritz, S. P.; Harrison, S. A.; Coe, D. M.; McGarrigle, E. M.; Aggarwal, V. K.; J. Org. Chem., 2014, 79, 10226-10239

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Synthesis of L-[5-11C]Leucine and L-α-[5-11C]Methylleucine via Pd0-mediated 11C-Methylation and Microfluidic Hydrogenation: Potentiality of Leucine PET Probes for Tumor Imaging

Takatani, S. et al.; ChemMedChem, 2021, 16(21), 3271-3279

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Synthesis of laminarin fragments and evaluation of a β-(1,3) glucan hexasaccaride-CRM197 conjugate as vaccine candidate against Candida albicans

Adamo, R.; Tontini, M.; Brogioni, G.; Romano, M. R.; Contantini, G.; Danieli, E.; Proietti, D.; Berti, F.; Constantino, P.; Journal of Carbohydrate Chemistry, 2011, 30, 249-280

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Synthesis of macrolide-saccharide hybrids by ring-closing metathesis of precursors derived from glycitols and benzoic acids

Matos, M-C.; Murphy, P. V.; J. Org. Chem., 2007, 72, 1803-1806

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Synthesis of Mepivacaine and Its Analogues by a Continuous-Flow Tandem Hydrogenation/Reductive Amination Strategy

Suveges, N. S. et al.; Eur. J. Org. Chem., 2017, 6511-6517

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Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors

Tite, T.; Tomas, L.; Docsa, T.; Gergely, P.; Kovensky, J.; Gueyrard, D.; Wadouachi, A.; Tetrahedron Letters, 2012, 53, 959-961

Link to article

Synthesis of N-hydroxypyrazin-2(1H)-ones via selective O-debenzylation of 1-benzyloxypyrazin-2(1H)-ones using flow methodology

Mai, A. H.; De Borggraeve, W. M.; J. Flow Chem., 2015, 5(1), 6-10

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Synthesis of N-propynyl analogues of peptide nucleic acid (PNA) monomers and their use in the click reaction to prepare N-functionalized PNAs

Howarth, N. M.; Ricci, J.; Tetrahedron, 2011, 67, 9588-9594

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Synthesis of natural and unnatural cyclooligomeric depsipeptides enabled by flow chemistry

Lucke, D.; Dalton, T.; Ley, S. V.; Wilson Z. E.; Chem. Eur. J., 2016, 22(12), 4206-4217

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Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds

Joyard, Y.; Azzouz, R.; Bischoff, L.; Papamicael, C.; Labar, D.; Bol, A.; Bol, V.; Vera, P.; Gregoire, V.; Levacher, V.; Bohn, P.; Bioorg. Med. Chem., 2013, 21, 3680-3688

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Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity

Borcard, F.; Baud, M.; Bello, C.; Dal Bello, G.; Grossi, F.; Pronzato, P.; Cea, M.; Nencioni, A.; Vogel, P.; Bioorg. Med. Chem. Lett., 2010, 20(17), 5353-5356

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Synthesis of new tetrahydropyridopyrazine derivatives via continuous flow chemistry approach and their spectroscopic characterizations

Parmar, N. D. et al.; J. Heterocyclic Chem., 2021, 58(7), 1437-1445

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Synthesis of Nontoxic Protoflavone Derivatives through Selective Continuous‐Flow Hydrogenation of the Flavonoid B‐Ring

Otvos, S. B. et al.; ChemPlusChem, 2018, 83(2), 72-76

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Synthesis of Novel Camphor-Derived Bifunctional Thiourea Organocatalysts

Ricko, S.; Golobic, A.; Svete, J.; Stanovnik, B.; Groselj, U.; Chirality, 2015, 27(1), 39-52

Link to article

Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups and their evaluation as antimicrobial agents

Workman, D. G.; Hunter, M.; Dover, L. G.; Tetard, D.; Journal of Inorganic Biochemistry, 2016, 160, 49-58

Link to article

Synthesis of oxaspiropiperidines as a strategy for lowering logD

Cernak, T.; Dykstra, K.; Levorse, D.; Verras, A.; Balkovec, J.; Nargund, R.; DeVita, R.; Tetrahedron Letters, 2011, 52, 6457-6459

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Synthesis of phenols via fluoride-free oxidation of arylsilanes and arylmethoxysilanes

Rayment, E. J.; Summerhill, N.; Anderson, E. A.; J. Org. Chem., 2012, 77(16), 7052-7060

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Synthesis of Polyanionic C5-Modified 2′-Deoxyuridine and 2′-Deoxycytidine-5′-Triphosphates and Their Properties as Substrates for DNA Polymerases

Dutson, C. et al.; Molecules, 2021, 26, 2250

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Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations

Baumann, M.; Baxendale, I. R.; Hornung, C. H.; Ley, S. V.; Rojo, M. V; Roper, K. A.; Molecules, 2014, 19(7), 9736-9759

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Synthesis of secondary amines by reductive amination of aldehydes with nitroarenes over supported copper catalysts in a flow reactor

Artiukha, E. A. et al.; Catalysis Communications, 2017, 102, 108-113

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Synthesis of spirocyclic thiazolidinediones using ring-closing metathesis and one-pot sequential ring-closing/cross metathesis

Dhara, K.; Paladhi, S.; Midya, G. C.; Dash, J.; Org. Biomol. Chem., 2011, 9, 3801-3807

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Synthesis of Staphylococcus aureus type 5 capsular polysaccharide repeating unit using novel L-FucNAc and D-FucNAc synthons and immunochemical evaluation

Danieli, E.; Proietti, D.; Brogioni, G.; Romano, M. R.; Cappelletti, E.; Tontini, M.; Berti, F.; Lay, L.; Costantino, P.; Adamo, R.; Bioorg. Med. Chem., 2012, 20, 6403-6415

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Synthesis of sugar-lactams from azides of glucuronic acid

Loukou, C.; Tosin, M.; Muller-Bunz, H.; Murphy, P. V.; Carbohydrate Research, 2007, 342(12-13), 1953-1959

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Synthesis of symmetric dinitro‐functionalised Tröger’s base analogues

Bhuiyan, M. D. H.; Mahon, A. B.; Jensen, P.; Clegg, J. K.; Try, A. C.; Eur. J. Org. Chem., 2009, 5, 687-698

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Synthesis of 2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane (TAIW) from 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazaisowurtzitane (TADBIW) by catalytic hydrogenolysis using a continuous flow process

Dong, K.; Sun, C. H.; Song, J. W., Wei, G. X.; Pang, S. P.; Org. Process Res. Dev., 2014, 18, 1321-1325

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Synthesis of tetrazole analogues of amino acids using Fmoc chemistry: isolation of amino free tetrazoles and their incorporation into peptides

Sureshbabu, V. V.; Venkataramanarao, R.; Naik, S. A.; Chennakirshnareddy, G.; Tetrahedron Letters, 2007, 48(39), 7038-7041

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Synthesis of the Hexasaccharide Related to the Exopolysaccharide from Lactobacillus mucosae VG1 through Regioselective Glycosylation

Adak, A. et al.; Org. Lett., 2023, 25(25), 4711–4714

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Synthesis of the Lipophilic Amine Tail of Abediterol Enabled by Multiphase Flow Transformations

Garcia-Lacuna, J. et al.; Org. Process Res. Dev., 2021, 25, 947-959

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Synthesis of the tetrasaccharide related to the repeating unit of the O-antigen from Azospirillum brasilense Jm125A2 in the form of its 2-aminoethyl glycoside

Sarkar, V. et al.; Carbohydrate Research, 2018, 470, 13-18

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Synthesis of the tetrasaccharide repeating unit of the β-Kdo-containing exopolysaccharide from Burkholderia pseudomallei and B. cepacia complex

Laroussarie, A.; Barycza, B.; Andriamboavonjy, H.; Kenfack, M. T.; Bleriot, Y.; Gauthier, C.; J. Org. Chem., 2015, 80(20), 10386-10396

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Synthesis of the tetrasaccharide repeating unit of the O-antigen from Pseudomonas putida BIM B-1100 having rare D-Quip3NAc

Bera, M. et al.; Carbohydrate Research, 2020, 489, 107955

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Synthesis of the tetrasaccharide repeating unit of the O-glycan from the polar flagellum flagellin of Azospirillum brasilense Sp7

Pal, K. B.; Mukhopadhyay, B.; Carbohydrate Research, 2014, 400, 9-13

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Synthesis of the trisaccharide repeating unit of the lipopolysaccharide from Moritella viscosa strain M2-226

Pal, K. B.; Verma, P. R.; Gupta, T.; Mukhopadhyay, B.; Journal of Carbohydrate Chemistry, 2015, 34(4), 173-182

Link to article

Synthesis of two trisaccharides related to the hepatoprotective phenylethanoids leonoside E and F isolated from Leonurus japonicus Houtt

Budhadev, D.; Mukhopadhyay, B.; Carbohydrate Research, 2014, 384, 51-55

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Synthesis of unique scaffolds via Diels-Alder cycloadditions of tetrasubstituated cyclohexadienes

Jones, A. L.; Snyder, J. K.; Organic Letters, 2010, 12(7), 1592-1595

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Synthesis of unsaturated secondary amines by direct reductive amination of aliphatic aldehydes with nitroarenes over Au/Al2O3 catalyst in continuous flow mode

Artiukha, E. A. et al.; RSC Adv., 2016, 6, 88366-88372

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Synthesis of γ-valerolactone using a continuous-flow reactor

Tukacs, J. M.; Jones, R. V.; Darvas, F.; Dibo, G.; Lezsak, G.; Mika, L. T.; RSC Adv., 2013, 3, 16283-16287

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Synthesis, Properties, and Two-Dimensional Adsorption Characteristics of [6]Hexahelicene-7-carboxylic acid

van der Meijden, M. W. et al.; Chem. Eur. J., 2016, 22, 14633-14639

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Synthesis, SAR, and pharmacological characterization of brain penetrant P2X7 receptor antagonists

Savall, B. M.; Wu, D.; Angelis, M. D.; Carruhters, N. I.; Ao, H.; Wang, Q.; Lord, B.; Bharrachrya, A.; Letavic, M. A.; ACS Med. Chem. Lett., 2015, 6, 671-676

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Synthesis, structure–activity, and structure–stability relationships of 2‐substituted‐N‐(4‐oxo‐3‐oxetanyl) N‐acylethanolamine acid amidase (NAAA) inhibitors

Vitale, R.; Ottonello, G.; Petracca, R.; Bertozzi, S. M.; Ponzano, S.; Armirotti, A.; Berteotti, A.; Dionisi, M.; Cavalli, A.; Piomelli, D.; Bandiera, T.; Bertozzi, F.; ChemMedChem, 2014, 9, 323-336

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Synthetic Access to Noncanonical Strigolactones: Syntheses of Carlactonic Acid and Methyl Carlactonoate

Dieckmann, M. C. et al.; J. Org. Chem., 2018, 83, 125-135

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Synthetic approaches to the C11–C27 fragments of bryostatins

Green, A. P. et al.; Org. Biomol. Chem., 2017, 15, 9475-9496

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Synthetic multivalent ligands for cholera & cholera-like toxins: Protected cyclic neoglycopeptides

Kumar, V.; Yadav, N.; Kartha, K. P. R.; Carbohydrate Research, 2016, 431, 47-55

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Synthetic studies toward the C32–C46 segment of hemicalide. Assignment of the relative configuration of the C36–C42 subunit

Specklin, S.; Boissonnat, G.; Lecourt, C.; Sorin, G.; Lannou, M. I.; Ardisson, J.; Sautel, F.; Massiot, G.; Meyer, C.; Cossy, J.; Org. Lett., 2015, 17(10), 2446-2449

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Systematic evaluation of the palladium-catalyzed hydrogenation under flow conditions

Hattori, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H.; Tetrahedron, 2014, 70(32), 4790-4798

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Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer’s disease

Jerabek, J. et al.; Eur. J. Med. Chem., 2017, 127, 250-262

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Tailoring nitrogen-doped carbons as hosts for single-atom catalysts

Buchele, S.; Chen, Z.; Mitchell, S.; Hauert, R.; Krumeich, F.; Perez-Ramirez, J.; ChemCatChem, 2019, 11(12), 2812-2820

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Tailoring the framework composition of carbon nitride to improve the catalytic efficiency of the stabilised palladium atoms

Vorobyeva, E. et al.; J. Mater. Chem. A, 2017, 5, 16393-16403

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Taming hazardous chemistry by continuous flow technology

Movsisyan, M.; Delbeke, E. I. P.; Berton, J. K. E. T.; Battilocchio, C.; Ley, S. V.; Stevens, C. V.; Chem. Soc. Rev., 2016, 45, 489-4928

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Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release

Morese, P. A. et al.; J. Med. Chem., 2023, Accepted manuscript

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Targeting Her2-insYVMA with Covalent Inhibitors—A Focused Compound Screening and Structure-Based Design Approach

Lategahn, J. et al.; J. Med. Chem., 2020, 63(20), 11725-11755

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Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry

Buglioni, L. et al.; Chem. Rev., 2022, 122, 2752-2906

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Telescoped sequence of exothermic and endothermic reactions in multistep flow synthesis

Sharma, Y.; Nikam, A. V.; Kulkarni, A. A.; Org. Process Res. Dev., 2018, 23(2), 170-176

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Telescoped synthesis of vicinal diamines via ring-opening of electrochemically generated aziridines in flow

Laktsevich-Iskryk, M. et al.; J. Flow Chem., 2023, DOI: 10.1007/s41981-023-00296-8

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Tetrahydroisoquinolinone‐based steroidomimetic and chimeric microtubule disruptors

Leese, M. P.; Jourdan, F. L.; Major, M. R.; Dohle, W.; Hamel, E.; Ferrandis, E.; Fiore, A.; Kasprzyk, P. G.; Potter, B. V. L.; ChemMedChem, 2014, 9(1), 85-108

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The assembly of integrated continuous flow platform for on-demand rosiglitazone and pioglitazone synthesis

Purwa, M. et al.; React. Chem. Eng., 2022, 7, 2084-2092

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The changing face of organic synthesis

Ley, S. V.; Baxendale, I. R.; Chimia, 2008, 62(3), 162-168

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The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors

Carter, C. F.; Baxendale, I. R.; Pavey, J. B. J.; Ley, S. V.; Org. Biomol. Chem., 2010, 8, 1588-1595

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The continuous synthesis and application of graphene supported palladium nanoparticles: a highly effective catalyst for Suzuki-Miyaura cross-coupling reactions

Brinkley, K. W.; Burkholder, M.; Siamaki, A. R.; Belecki, K.; Gupton, B. F.; Green Process. Synth., 2015, 4(3), 241-246

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The Cooperative Research Centre for Cancer Therapeutics: bridging the gap between leading cancer research at Australia’s universities and developing novel cancer drugs

Baell, J. B.; Heathers, G.; Sage, C.; Future Med. Chem., 2010, 2, 941-947

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The Current Role of Microfluidics in Radiofluorination Chemistry

Knapp, K-A. et al.; Mol. Imaging Biol., 2020, 22, 463-475

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The development of poly(dendrimer)s for advanced processing

Gunning, J. P.; Levell, J. W.; Wyatt, M. F.; Burn, P. L.; Robertson, J.; Samuel, I. D. W.; Polym. Chem., 2010, 1, 730-738

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The dual reactivity of Weinreb amides applied to the late-stage divergent functionalisation of meso pyrrolidines

Boufroura, H.; Sevaille, L.; Gigant, N.; Drege, E.; Joseph, D.; New J. Chem., 2018, 42, 12403-12411

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The expanding utility of continuous flow hydrogenation

Cossar, P. J.; Hizartzidis, L.; Simone, M. I.; McCluskey A.; Gordon, C. P.; Org. Biomol. Chem., 2015, 13, 7119-7130

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The first case of competitive heterogeneously catalyzed hydrogenation using continuous-flow fixed-bed reactor system: Hydrogenation of binary mixtures of activated ketones on Pt-alumina and on Pt-alumina-cinchonidine catalysts

Szollosi, G.; Makra, Z.; Fulop, F.; Bartok, M.; Catalysis Letters, 2011, 141, 1616-1620

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The flow synthesis of heterocycles for natural product and medicinal chemistry applications

Baumann, M.; Baxendale, I. R.; Ley, S. V.; Molecular Diversity, 2011, 15(3), 613-630

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The future of organic synthesis

Kundig, P.; Science, 2006, 314, 430-431

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The Hitchhiker’s Guide to Flow Chemistry

Plutschack, M. B. et al.; Chem. Rev., 2017, 117(18), 11796-11893

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The identification of indacaterol as an ultralong-acting inhaled β2-adrenoceptor agonist

Baur, F.; Beattie, D.; Beer, D.; Bentley, D.; Bradley, M.; Bruce, I.; Charlton, S. J.; Cuenoud, B.; Ernst, R.; Fairhurst, R. A.; Faller, B.; Farr, D.; Keller, T.; Fozard, J. R.; Fullerton, J.; Garman, S.; Hatto, J.; Hayden, C.; He, H.; Howes, C.; Janus, D.; Jiang, Z.; Lewis, C.; Loeuillet-Ritzler, F.; Moser, H.; Reilly, J.; Steward, A.; Sykes, D.; Tedaldi, L.; Trifilieff, A.; Tweed, M.; Watson, S.; Wissler, E.; Wyss, D.; J. Med. Chem., 2010, 53, 3675-3684

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The influence of linkages between 1-Hydroxy-2(1H)-pyridinone Coordinating Groups and a Tris(2-aminoethyl)amine core in a novel series of synthetic Hexadentate Iron(III) Chelators on antimicrobial activity

Workman, D. G.; Hunter, M.; Wang, S.; Brandel, J.; Hubscher, V.; Dover, L. G.; Tetard, D.; Bioorg. Chem., 2019, accepted manuscript

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The integration of flow reactors into synthetic organic chemistry

Baxendale, I. R.; J. Chem. Technol. Biotechnol., 2013, 88, 519-552

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The microwave-to-flow paradigm: Translating high-temperature batch microwave chemistry to scalable continuous-flow processes

Glasnov, T. N.; Kappe, C. O.; Chem. Eur. J., 2011, 17, 11956-11968

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The recent advancement of hydrogenation technology and their implications for drug discovery research

Spadoni, C.; Jones, R.; Urge, L.; Darvas, F.; Chemistry Today, 2005, January/February, 36-39

The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches

Gordon, P. C.; Org. Biomol. Chem., 2018, 16, 180-196

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The role of flow in green chemistry and engineering

Newman, S. G.; Jensen, K. F.; Green Chem., 2013, 15, 1456-1472

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The role of water in catalytic biomass-based technologies to produce chemicals and fuels

Mika, L. T.; Csefalvay, E.; Horvath, I. T.; Catalysis Today, 2015, 247, 33-46

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The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

Baumann, M.; Baxendale, I. R.; Beilstein J. Org. Chem., 2015, 11, 1194-1219

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The synthesis of azabicyclic heterocycles

Darout, E.; Basak, A.; Tetrahedron Letters, 2010, 51, 2998-3001 Link to article

The titanium-mediated double reductive cleavage of cyclic sulfonamides for the synthesis of aryl pyrrolidines

Khalifa, A.; Evans, P.; J. Org. Chem., 2019, 84(5), 2969-2975

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The use of a continuous flow-reactor employing a mixed hydrogen–liquid flow stream for the efficient reduction of imines to amines

Saaby, S.; Knudsen, K. R.; Ladlow, M., Ley, S. V.; Chem. Commun., 2005, 23, 2909-2911

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The use of gases in flow synthesis

Mallia, C. J.; Baxendale, I. R.; Org. Process Res. Dev., 2016, 20(2), 327-360

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Thermochemiluminescence-Based Sensitive Probes: Synthesis and Photophysical Characterization of Acridine-Containing 1,2-Dioxetanes Focusing on Fluorophore Push-Pull Effects

Moroni, G. et al.; ChemPhotoChem, 2022, 6(1), e202100152

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Two-photon fluorescent chemosensors based on the GFP-chromophore for the detection of Zn2+ in biological samples – From design to application

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Two step continuous-flow synthesis of benzocaine

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USP7 small-molecule inhibitors interfere with ubiquitin binding

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Visually following the hydrogenation of curcumin to tetrahydrocurcumin in a natural product experiment that enhances student understanding of NMR spectroscopy

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VUT-MK142: a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes

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Wet-Chemical Etching and Delamination of MoAlB into MBene and Its Outstanding Photocatalytic Performance

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Yolk‐shell‐mesostructured silica‐supported dual molecular catalyst for enantioselective tandem reactions

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