CatCart Changer™

The CatCart Changer™ is an automated system for alternating between different catalyst cartridges whilst working in a flow chemistry environment using ThalesNano H-Cube series reactors.

The 6-channel CatCart Changer™ works by switching the flow from one cartridge to another ‘on the fly’, enabling the user to run samples on up to 6 different catalysts at temperatures and pressures of up to 100°C (212°F) and 100 bar (1450 psi), respectively.

When combined with the H-Cube Pro™, the CatCart Changer™ allows the easy screening of a selection of catalysts as well as reaction optimization. When used with the H-Cube Pro™ in conjunction with the H-Cube Autosampler™, it gives the possibility for screening and optimization to be run on a fully automated basis and for simplified sample injection and fraction collection of the end product.

How does it work?

A 6-channel valve, operated either through the H-Cube® or H-Cube Pro™, or in conjunction with the Autosampler™ integration software via PC, controls the flow of the compound into any of the 6 CatCart® chambers in the CatCart Changer™. The temperature and pressure can be set individually for each catalyst.


The CatCart Changer™ has a number of useful applications:

Catalyst Screening

Using a different catalyst in each chamber enables up to 6 catalysts to be screened with a particular compound.

Reaction Optimization

With the CatCart Changer™, with the same catalyst in each chamber pre-set to different temperatures and pressures, the optimization process occurs without any manual intervention. Using the Autosampler™, the different fractions can be collected and sorted for analysis.

Library Production

Using the same catalyst in each chamber, a library of compounds can be synthesized in an automated environment without fear of catalyst deactivation. This is achieved through continually directing the compound through a new, fresh CatCart® at pre-set intervals, ensuring that the catalyst does not deactivate during the library production.

Scale up

Using the same type of CatCart® in all holders, a large amount of the desired compound can be prepared: the substrate is changed to a fresh cartridge after a user specified amount of time.

Compatible devices

  • H-Cube®
  • H-Cube Pro™
  • Autosampler™ system
Technical data
Pressure range from atmospheric pressure to 100 bar
Temperature range from room temperature to 100 °C
Dimensions height: 310 mm (12.2”)
width: 270 mm (10.6”)
depth: 315 mm (12.4”)
Weight 12 kg (27 lbs)
Mains voltage 100 – 230 V (AC)
Mains frequency 50 – 60 Hz
Power uptake max. 500 VA
Fuses 2×3.15A – 230V, 2×6.3 A – 117V