CatCart Changer™


The CatCart Changer™ is an automated system for alternating between different catalyst cartridges whilst working in a flow chemistry environment using ThalesNano H-Cube series reactors.

The 6-channel CatCart Changer™ works by switching the flow from one cartridge to another ‘on the fly’, enabling the user to run samples on up to 6 different catalysts at temperatures and pressures of up to 100°C (212°F) and 100 bar (1450 psi) respectively.

When combined with the H-Cube Pro, the CatCart Changer™ allows the easy screening of a selection of catalysts as well as reaction optimization. When used with the H-Cube Pro in conjunction with the H-Cube Autosampler, it gives the possibility for such screening and optimization to be run on a fully automated basis and for simplified sample injection and fraction collection of the end product.

How does it work?

A 6-channel valve, operated either through the H-Cube or H-Cube Pro or in conjunction with the Autosampler integration software via PC, controls the flow of the compound into any of the 6 CatCart chambers in the CatCart Changer™. The temperature and pressure can be set individually for each catalyst.


The CatCart Changer™ has a number of useful applications:

Catalyst Screening

Using a different catalyst in each chamber enables up to 6 catalysts to be screened with a particular compound.

Reaction Optimization

With the CatCart Changer™, with the same catalyst in each chamber pre-set to different temperatures and pressures, the optimization process occurs without any manual intervention. Using the Autosampler, the different fractions can be collected and sorted for analysis.

Library Production

Using the same catalyst in each chamber, a library of compounds can be synthesized in an automated environment without fear of catalyst deactivation. This is achieved through continually directing the compound through a new, fresh CatCart® at pre-set intervals, ensuring that the catalyst does not deactivate during the library production.

Scale up

Using the same type of CatCart® in all holders, a large amount of the desired compound can be prepared: the substrate is changed to a fresh cartridge after a user specified amount of time.

Compatible devices

  • H-Cube
  • H-Cube Pro
  • Autosampler system
Technical data
Pressure range from atmospheric pressure to 100 bar
Temperature range from room temperature to 100 °C
Dimensions height: 310 mm (12.2”)
width: 270 mm (10.6”)
depth:315 mm (12.4”)
Weight 12 kg (27 lbs)
Mains voltage 100 – 230 V (AC)
Mains frequency 50 – 60 Hz
Power uptake max. 500 VA
Fuses 2×3.15A – 230V, 2×6.3 A – 117V