H-Cube® Advance
The Future of Safe and Efficient Hydrogenations
Improved chemical synthesis in continuous flow
The H-Cube® Advance is the next evolution in chemical synthesis, building on the proven success of our first H-Cube®, the R&D Top 100 winner unit, and the well-known H-Cube® Pro. Designed for modern laboratories, this push-button synthesis platform offers advanced features, a sleek and user-friendly interface, and enhanced functionality to simplify synthetic chemistry workflows in a safe manner.
Extended application capabilities
This compact, bench-top flow reactor, in addition to maintaining the basic functions of the original system, contains a number of improvements:
- Built-in MFC for the precise dosing of the produced hydrogen or the treatment of the external gases
- User-friendly interface, ergonomic design
- 3.0 (99.9%) produced hydrogen purity
- Compatibility with the THS ReAction software
Sign up to our upcoming webinar!
Learn how to expand your scope of applications by joining our free live webinar, hosted by our Director of Chemistry, who will explore the fundamentals of flow hydrogenation, and showcase the wide range of applications enabled by our newest flow reactor, the H-Cube® Advance. The webinars will be held on May 27, 4PM UTC, and May 29, 8AM UTC, to accommodate researchers globally. Both webinars will be held on our YouTube channel.
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May 27, 4PM UTC
Recommended for American and European time zones
May 29, 8AM UTC
Recommended for European and Asian time zones
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Features of the H-Cube® Advance
Built-in Mass Flow Controller (MFC): Ensures precise gas control, whether 99.9% pure in-situ hydrogen or other external gases for reproducible, scalable synthesis.
External Gas Inlet: Allows the introduction of additional gases like oxygen, nitrogen, carbon oxides, and many more through the built-in mass flow controller.
External water reservoir: Users can choose between flasks of variable sizes to fit specific needs, which are completely detachable from the device and easy to clean.
Next-Generation Water Electrolysis Cell: Efficient single-cell operation for consistent on-demand hydrogen production, which provides longer cell life and lower maintenance costs.
CatCart® technology: Ensures safe and reliable catalyst handling by minimizing exposure to pyrophoric and toxic materials. The H-Cube® Advance is equipped with an easy to use CatCart® holder with ergonomic fitting nut knob and lift lever, moreover, the flow reactor is compatible with all ThalesNano CatCarts®.
Upgraded Internal and External Parts: The flow reactor's built-in system valve improves reaction efficiency and control, moreover, it comes with a built-in pressure sensor and mixer module, eliminating the need for further external add-ons - all it needs is a ThalesNano HPLC or Knauer pump to introduce the solvent and/or reactant to the system.
Touch Display with an User Friendly Interface: The reactor comes with an external 11.6" touch screen, and a seamlessly operable software equipped with automated and manual mode.
Automated Mode
Manual Mode
How does it work?
The H-Cube® Advance is mainly used for hydrogenation of many different starting material types, as well as catalyst screening. Additional supplied equipment, such as the HPLC pump, is used to introduce the reactant into the device, where the solution of reactant is mixed with the in-situ on-demand generated hydrogen.
The pre-heated mixture is then transferred to a disposable catalyst cartridge (CatCart®) which is preloaded with the required solid catalyst.
The mixture is then passed through the solid phase and then collected in a flask. In most reactions the only work-up required is the evaporation of the solvent.
Applications
Reactions with hydrogen gas:
Triple bond full reduction, debenzylation, nitrile reduction, selective nitro reduction, selective triple to double bond reduction, selective double bond reduction, aldose reduction, aromatic heterocycle reduction, aromatic ring reduction
Other reactions:
Deuteration, Sonogashira coupling, Suzuki coupling
Modules for the H-Cube® Advance
THS System Controller® and THS ReAction® Software
The THS System Controller® and its PC application, the THS ReAction® Software are designed to control ThalesNano’s other flow chemistry modules, using a computer with an user-friendly software. The THS System Controller® ensures stable communication between the laboratory devices, while the THS ReAction® Software enables remote control of all instruments in the system. Using this software, the H-Cube® Advance can be connected to a fleet system.
Phoenix™ Flow Reactor
The Phoenix™ Flow Reactor is a powerful instrument which can be heat the reaction zone up to 450 °C and is compatible with multiple types and sizes of reactors (CatCarts®, MidiCarts™, coiled reactors, metal-metal sealed catalyst columns). When connected to the H-Cube® Advance , it is possible to set up a system to perform single or double-step reactions in series and to monitor and control the whole process using the interface of the H-Cube® Advance.
Autosampler system
Fully automated processes can be implemented when connecting the H-Cube® Advance with one of the Brooks AIM3000 Autosampler systems, designed to automate the continuous sampling of liquid samples into an analyzer. Connecting the H-Cube® Advance to an Autosampler from the AIM3000 family makes it ideal for performing optimization studies or catalyst screening.
System specifications of the H-Cube® Advance
| Technical Specifications | |
|---|---|
| Solvent and reagent flow rate range | 0.001-10 mL/min |
| Internal H2 gas flow rate range | 1-70 NmL/min |
| Gas types | Internal H2 or external custom |
| Pressure range | Atmospheric to 100 bar |
| Reactor temperature range | 0 – 150 °C (32 – 302 °F) |
| Dimensions (H x W x D) | 330 x 320 x 330 mm (w/o display) |
| Display size | 11.6” (29.464 cm) |
| Weight | 18 kg |
| Mains range | 110 – 240 V AC, 50/60 Hz, 500 W |
Do you have questions?
Reach out to us at any time and experience fast and efficient support tailored to your specific needs.