Application Notes

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At ThalesNano, we are dedicated to making knowledge accessible to all scientists. Our mission is to support education, research, and scientific collaborations, empowering scientists to share their experiences and find inspiration. Explore our Application Notes to discover how ThalesNano instruments can change your chemical research and help you achieve your chemistry goals.

 

Find the Application Notes sorted by instruments:
H-Cube
H-Genie
Phoenix Flow Reactor
Gas Module
PhotoCube

H-Cube Application Notes

The following application notes show the wide range of chemical reactions and synthetic methods which can be implemented in our H-Cube® continuous flow reactor systems.

Coupling a Spinsolve® NMR spectrometer to an H-Cube® Pro flow reactor for fast reaction optimization

In this application note, we have integrated a Spinsolve 80 ULTRA benchtop NMR spectrometer from Magritek with an H-Cube® Pro flow reactor.

Automated hydrogenation using the H-Cube continuous flow reactor

The pharmaceutical industry is continually searching to automate techniques for rapid optimization or library production. The automation of hydrogenation is one of those processes that is drawing high interest due to its frequency in drug synthesis.

Catalyst screening and profiling with the H-Cube systems

ThalesNano is already well-known for its novel solutions in revolutionizing heterogeneous catalytic hydrogenations with its H-Cube hydrogenator, while the expanded H-Cube series of fixed bed reactors offers a broad range of chemistry applications.

Deuteration reactions using the H-Cube continuous flow reactor

Deuterium-labeled compounds are widely used as research tools in chemistry: for proving reaction mechanisms, for investigation of a compound’s pharmacokinetic properties, as internal standards in MS, or for compound structure determination in NMR.

Fast hydrogenation reaction examples using the H-Cube

The hydrogenation of a series of functional groups has been performed using H-Cube. These experiments demonstrate that the H-Cube can perform a diverse range of heterogeneous hydrogenation reactions.

Increased throughput delivered by the H-Cube Pro

The H-Cube Pro offers greater hydrogen production capability. The reduction of 2,4-dinitroanisole was chosen as a model reaction as it has high hydrogen demand (6 mol H2 per 1 mol substrate) and involves reduction of two nitro groups.

Radiochemical synthesis of 18F-labelled compounds

In this application note we demonstrate the first application on flow hydrogenation for the development of a PET radiotracer in a fast, efficient and reproducible way, with the H-Cube Pro flow reactor.

Sonogashira and Suzuki reactions with the H-Cube

When utilizing the “No H2” mode of the system, the H-Cube acts like a general flow reactor capable of performing other heterogeneous reactions at temperatures and pressures up to 100°C and 100 bar, respectively.

Asymmetric hydrogenation using H-Cube continuous flow reactor

Catalytic asymmetric hydrogenation is one of the most efficient and convenient methods for synthesizing optically active compounds, which are widely used in the pharmaceutical and fine chemical industries.

Deprotection reactions using the H-Cube continuous flow reactor

Protecting groups play a central role in modern organic synthesis. Benzyl groups and Cbz groups are some of the most commonly used protecting groups and play a central role in the protection of alcohols, carboxylic acids and amines.

Difficult hydrogenations – saturation of func. pyridines

The H-Cube flow hydrogenation reactor is capable of performing reactions at 100 °C and 100 bar safely. The H-Cube’s improved mixing efficiency coupled with high temperature and pressure abilities means difficult reactions can be performed in minutes.

H-Cube Mini Plus – Application Overview

If you are looking for reaction examples with H-Cube Mini Plus, download our application overview. This short guide will help you to perform various types of hydrogenation reactions easily in a safe and efficient manner.

Medicinal chemistry application of chemoselective hydrogenation

In a medicinal chemistry project McCluskey and co-workers employed a series of chemoselective sequential hydrogenation reactions in order to access highly decorated norcantharidin analogues. This application note analyses their excellent work.

Rapid catalyst screening for Sonogashira coupling

In “No H2” mode, the H-Cube reactor can perform reactions at temperatures and pressures up to 100 °C and 100 bar, respectively in the absence of a reagent gas. In this application note we will be focusing on Sonogashira chemistry.

Synthesis of nanoparticles and their efficient use for reductions

In this application note we demonstrate the results of newly developed Pd, Ni nanocomposites and immobilized Ir complex catalysts for a wide range of chemical applications in the H-Cube and H-Cube Pro systems.

Using flow chemistry in agrochemical applications

In this application note we provide information from patents from major agrochemical companies, Syngenta and Dow Agrosciences, where flow chemistry was used for the synthesis of active compounds.

Ullmann-type reductive homo-coupling reactions at RT

In this application note we summarize the preparation of biaryls in a safe, fast and environmentally friendly continuous flow protocol of Feiz et al., where our H-Cube Mini™ reactor has been applied in a non-traditional way.

H-Genie Application Notes

Our collection of application notes showcases the many possibilities of using on-demand hydrogen generation in organic synthesis.

Kilogram scale synthesis of a Linezolid analogue intermediate

In this work, we present a large scale, two-step tandem technique for the synthesis of a Linezolid analogue key intermediate via the N-arylation of morpholine followed by a nitro group reduction in a flow reactor system.

Scaling-up a hydrogenation reaction in continuous flow

In this in-house reasearch, having the H-Genie® hydrogen generator and Phoenix Flow Reactor™ in our hands, we decided to scale-up the nitro reduction of methyl-4-nitrobenzoate to reach an input of 0.6 mol/hour of starting material.

Phoenix Flow Reactor Application Notes

Our collection of application notes showcases the extensive variety of chemical reactions and synthetic methods that can be effortlessly executed using our state-of-the-art Phoenix flow reactor systems.

Kilogram scale synthesis of a Linezolid analogue intermediate

In this work, we present a large scale, two-step tandem technique for the synthesis of a Linezolid analogue key intermediate via the N-arylation of morpholine followed by a nitro group reduction in a flow reactor system.

Ethanol oxidation with heterogeneous catalysis in flow

With the combination of ThalesNano’s Phoenix Flow Reactor™ and Gas Module™, a reactor system has been built, which is capable to control high temperature–high pressure triphasic gas-liquid-solid reactions providing a safe and efficient environment.

Green and sustainable production of N-alkyl imidazoles

Ionic liquids have gained great interest during the last three decades due to their green and sustainable behavior along with their added versatility as solvents. N-Alkylimidazole derivatives are key intermediates for the synthesis of quaternary ionic liquid salts.

Polymerization and grafting onto particle surfaces

A facile method was demonstrated to synthesize homopolymers and block copolymer grafted inorganic particles using continuous flow chemistry in an environmentally friendly aqueous media using the Phoenix Flow Reactor.

Scaling-up a hydrogenation reaction in continuous flow

In this in-house reasearch, having the H-Genie® hydrogen generator and Phoenix Flow Reactor™ in our hands, we decided to scale-up the nitro reduction of methyl-4-nitrobenzoate to reach an input of 0.6 mol/hour of starting material.

Direct alkylation of N-heterocycle under het. catalytic conditions

Flow reactors can be utilized to implement high temperature and high pressure chemical reactions. With this, chemists can move towards extending the accessible chemical parameter space to access new molecules and applications.

Fast and continuous transfer hydrogenation of aromatic nitriles

The reduction of nitriles is one of the most common routes to synthesize primary amines, which are key intermediates in fine-chemical, pharmaceutical, and agricultural industries. Both direct and transfer hydrogenation can be used for this purpose.

High Pressure CO2 activation in gas phase with the Phoenix™

This application note evaluates the performance of the Phoenix Flow Reactor™ and the Gas Module in the production of value-added chemicals (other than methane) from a low-cost renewable carbon dioxide source.

Safe and efficient Diels-Alder cycloaddition reactions

Modern flow chemistry methods offer new chemical space for drug discovery programs: novel compounds can be synthesized in dedicated high temperature/high pressure (high T/p) reactors, while reaction times can be shortened dramatically.

Versatile chemistry examples performed on the Phoenix

In this application note, we demonstrate the flexibility of the Phoenix Flow Reactor by presenting various applications such as N-substitution, thermal Boc-removal, scalable Claisen-rearrangement, and synthesis of soluble polyphosphate anions.

Gas Module Application Notes

Our application notes demonstrate the diverse array of chemical reactions and synthetic methods that can be seamlessly implemented using our Gas Module and complementary systems.

Ethanol oxidation with heterogeneous catalysis in flow

With the combination of ThalesNano’s Phoenix Flow Reactor™ and Gas Module™, a reactor system has been built, which is capable to control high temperature–high pressure triphasic gas-liquid-solid reactions providing a safe and efficient environment.

Gaseous reagent organic chemistry makes easy

Reactions such as carbonylation or oxidation can now be performed on the H-Cube® Pro at the same high pressure and ease of use, extending the reactor’s chemistry capacity significantly, as it is presented in this application note.

High Pressure CO2 activation in gas phase with the Phoenix™

This application note evaluates the performance of the Phoenix Flow Reactor™ and the Gas Module in the production of value-added chemicals (other than methane) from a low-cost renewable carbon dioxide source.

PhotoCube Application Notes

Learn how the PhotoCube can be used to perform advanced photochemical transformations.

Two-step telescoped photocatalytic Minisci reaction

Continuous flow technology enables the acceleration of the reaction, furthermore, multiple synthetic steps can be merged into one sequence with careful planning, resulting in higher yields.

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