H-Cube® Systems

Hydrogenation in Flow

 
The first H-Cube® system revolutionized laboratory hydrogenation when it was introduced in 2005, earning the prestigious R&D Top 100 award for ThalesNano in the same year. Since then, these reactors have established a new industry standard by combining on-demand hydrogen generation and continuous flow technology within a single instrument. The product family comprises three different reactors, catering to a wide range of user requirements.

The H-Cube® Mini Plus stands out for its user-friendly design, offering a modern and streamlined version of its original counterpart. With enhanced ease of use, this instrument ensures efficient small-scale laboratory hydrogenation.

On the other hand, the H-Cube® Advance is specially designed for complex hydrogenations and chemical synthesis with gases other than hydrogen. The built-in mass flow controller and the external gas inlet enables reactions with 14 different gases. Moreover, the flow reactor provides a wider temperature range (0-150 °C), higher hydrogen production rate, and an user-friendlier interface than its predecessor, the H-Cube® Pro. The H-Cube® Advance flow reactor's Hastelloy version is made out of Hastelloy C, enabling reactions with corrosive materials, like acids and chlorines.

With their cutting-edge features and capabilities, these flow hydrogenation reactors continue the legacy of the H-Cube® system, pushing the boundaries of laboratory hydrogenation technology. Over the years, they have been used all around the world for a wide range of applications and have been featured in numerous scientific publications.

Applications

Reactions with hydrogen gas:

• Triple bond full reduction
• Debenzylation
• Nitrile reduction
• Selective nitro reduction
• Selective triple to double bond reduction
• Selective double bond reduction
• Aldose reduction
• Aromatic heterocycle reduction
• Aromatic ring reduction

Other reactions:

• Deuteration
• Sonogashira coupling
• Suzuki coupling