H-Cube® Systems

On-demand hydrogen and continuous flow technology

Hydrogenation in flow

The first H-Cube® system revolutionized laboratory hydrogenation when it was introduced in 2005, earning the prestigious R&D Top 100 award for ThalesNano in the same year. Since then, these reactors have established a new industry standard by combining on-demand hydrogen generation and continuous flow technology within a single instrument. The product family comprises three different reactors, catering to a wide range of user requirements.

The H-Cube® Mini Plus stands out for its user-friendly design, offering a modern and streamlined version of its original counterpart. With enhanced ease of use, this instrument ensures efficient small-scale laboratory hydrogenation.

On the other hand, the H-Cube® Advance is specially designed for complex hydrogenations and chemical synthesis with gases other than hydrogen. The built-in mass flow controller and the external gas inlet enables reactions with 14 different gases. Moreover, the flow reactor provides a wider temperature range (0-150°C), higher hydrogen production rate, and an user-friendlier interface than its predecessor, the H-Cube® Pro. The H-Cube® Advance flow reactor's Hastelloy version is made out of Hastelloy C, enabling reactions with corrosive materials, like acids and chlorines.

With their cutting-edge features and capabilities, these flow hydrogenation reactors continue the legacy of the H-Cube® system, pushing the boundaries of laboratory hydrogenation technology. Over the years, they have been used all around the world for a wide range of applications and have been featured in numerous scientific publications.

H-Cube® Advance

Advanced hydrogenation and chemical synthesis

H-Cube® Advance Hastelloy

Applications with corrosive materials

H-Cube® Pro

Flow reactor for advanced hydrogenation

H-Cube® Pro Hastelloy

Improved chemical resistance for hydrogenation

H-Cube® Mini Plus

Safe and easy hydrogenation

Applications

Reactions with hydrogen gas:

Triple bond full reduction, debenzylation, nitrile reduction, selective nitro reduction, selective triple to double bond reduction, selective double bond reduction, aldose reduction, aromatic heterocycle reduction, aromatic ring reduction, etc.

Other reactions:

Deuteration, Sonogashira coupling, Suzuki coupling, etc.

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