IceCube™ Flow Reactor

Safe and easy exothermic reactions


For further information about the availability, please contact us at

Exothermic reactions, by their very nature, often progress rapidly through unstable intermediates. Maintaining a firm control over parameters such as temperature and pressure is problematic, so their utilization is limited in synthetic practice. However, flow techniques have the potential of keeping such reactions under control via their improved heat and mass transfer capabilities, allowing one to exploit untapped or avoided chemistries.

The IceCubeTM is a low temperature, continuous flow reactor. The reagents are continuously pumped through the reaction zone and the product is collected in a flask after the reaction takes place. The device has two reaction zones, which can each be cooled down or heated to -70°C – +80°C and -30°C – +80°C respectively, so multistep reactions may be performed. This includes reactions where hazardous intermediates can be formed and reacted without isolation. The IceCubeTM has also been utilized for performing other hazardous reactions including ozonolysis, diazotization, lithiation, and nitration.


  • High energy reactions can be performed in a safe manner through excellent temperature control (from -50 °C to +80°C)
  • Modular system with software control
  • Two reactors are connected in sequence to react any hazardous intermediates generated immediately, without isolation
  • Continuous real-time feedback on the reaction parameters
  • Fast response to temperature change to avoid the generation of side product
  • Built-in safety features, automatic blockage/leakage detection
  • High chemical resistance allowing the use of different reagents, even strong acids
  • Easy scale-up from milligram to kilogram scale

How does it work?

The IceCube™ functions with Peltier plates technology to cool down to -50 °C using only tap water and electric power. The reactor is a PTFE tube with variable lengths, embodied in a metallic plate fixed on the Peltier plate. The starting/quenching materials are delivered continuously into the temperature-controlled reaction zones by the pumps and the product is collected in the end in a vial, flask or vessel.

The system is composed of 4 modules: Ozone Module, Pump Module, Reactor Module and Control Module. This makes the system highly customizable, the modules can be configured or purchased separately to match the arrangement that suits the selected application.

The Ozone Module gives you a safe and efficient way of generating ozone from oxygen. The oxygen amount is precisely controlled through the built-in mass flow controller. The system can also be used as a powerful and compact standalone ozonizer.

The Reactor Module is a very versatile reactor capable of controlling even extremely exothermic reactions safely and simply. Composed of two reactor plates with Peltier heating/cooling, the main zone works from -50 °C to 80 °C and the secondary from -30 °C to 80 °C. The reactor is made of PTFE embedded in a pair of aluminum plates. Many different volumes and arrangements allow for wide chemical compatibility. The system can be configured for 2, 3 or 4 reactants in one set of conditions. Difficult or dangerous reactions such as lithiation, azide generation or ozonolysis can be performed and quenched immediately eliminating the risk associated to dangerous intermediates.

The Pump Module consists of 2 rotary piston pumps, which have good chemical compatibility. The pumps are connected to two 3-way valves, which control the path of reactant or solvent through the reactor. Single or multiple pump modules can be purchased depending on the need of the chemist.

The Control Module enables the control of all the above parts as a whole system via a touch screen interface.

Technical Data
Pressure capabilityMax. 6 bar
Main reactor zone temp.From -50 °C to 80 °C
Main reactor zone volumeMax. 8 mL
Quench reactor zone temp.From -30 °C to 80 °C
Quench reactor zone volumeMax. 4 mL
Tubing1/16″ or 1/8″ PTFE
Liquid flow rates0.2 – 4 mL/min
Oxygen flow rate10 – 100 mL/min
Ozone productionup to 14% (at 20 NmL/min O2 flow rate)
Minimum purity of oxygen99.5%
System Specifications
Ozone ModuleWidth: 427 mm
Height: 220 mm
Depth: 330 mm
Weight: 11 kg
Pump ModuleWidth: 215 mm
Height: 378 mm
Depth: 417 mm
Weight: 14 kg
Reactor ModuleWidth: 534 mm
Height: 377 mm
Depth: 423 mm
Weight: 38 kg
Control ModuleWidth: 202 mm
Height: 158 mm
Depth: 224 mm
Weight: 3 kg


The general setup contains 3 or 4 main parts:
  • Pump Module (with two rotatory piston pumps)
  • Ozone Module (optional)
  • Reactor Module
  • Control Module
Yes, and they can be controlled by the Control Module as well.
By default, the Control Module provides you the following predefined configurations:
  • Ozonolysis (2 pumps are used and the Ozone Module)
  • 2 pumps with 1 reactor zone (2 pumps and the main reactor zone are in use)
  • 3 pumps with 2 reactor zones (3 pumps and both reactor zones are in use)
Yes, you can build your own configuration and introduce it in the software to be able to control each of the parts and monitor the parameters in real time through the Control Module.
You only need to include a mixer and other PTFE tubing to supply either a liquid or a gas, which takes only a few minutes to do.
The blockage can be washed out slowly, or since PTFE tubing is utilized, it can be easily replaced.
You can use either 1/8” or 1/16” PTFE tubes embedded in a pair of plates. The base plate has grooves so placing and changing the tubes in the coil takes only a few minutes.
You can change to another reaction volume easily in seconds. The length or internal diameter of the reaction line may be changed by swapping over reactor plates.
All the wetted parts of the system are made of PTFE, which can tolerate even strong acids.