Substitution reactions are well known and longtime applied reactions for building in or replacing function groups on aromatic or aliphatic organic molecules. Depending on the behavior of the leaving group, the reactions can be performed in a catalytic or non-catalytic environment. These reactions are good solutions to create new molecules and even whole structure libraries.
Substitution reactions with our reactors
The production rate of continuous flow reactions depends only on the longevity of the catalyst, or when the reaction goes in non-catalytic circumstances, the productivity depends only on time. Because of these, continuous flow solutions for these reactions can be interesting, especially for industry.
The H-Cube Pro® continuous flow reactor can maintain 150°C temperature and 100 bar pressure in liquid flow system. The applied pre-filled catalyst cartridges (CatCarts®) make chemical reactions easier and safer. The type of the catalyst can be chosen from the more than 100 available CatCarts.
When the Gas Module™ is attached to the system (with an external gas supply from cylinders up to 200 bar), 13 additional gases can be used with the H-Cube® Pro, allowing numerous variations of triphasic systems to be created, therefore the number of potential substitution reactions is very high.
ThalesNano’s Phoenix Flow Reactor™ can be heated up to even higher temperatures (up to 450°C). With this parameter space the application scale also rises. One of these applications is a fluorine-amine group exchange reaction we fulfilled with a stainless steel loop at 250°C.
Substitution reaction with the Phoenix Flow Reactor