Performing Thiol-Ene Click Reactions in the PhotoCube – New Application Note

Photochemistry in batch and flow

In a major leap forward for synthetic chemistry, ThalesNano’s PhotoCube™ is revolutionizing how photochemical reactions are performed—both in batch and continuous flow. This cutting-edge reactor, equipped with powerful LED panels across a wide wavelength range (365–623 nm), allows researchers to explore multiple photo-initiated reaction pathways simultaneously, including the Nobel Prize-winning thiol-ene click reactions.

Comparing Processes

A recent collaboration with the University of Debrecen highlights the PhotoCube™’s power: researchers achieved rapid, high-yield conversions in thiol-ene additions using methanol under blue LED light—demonstrating the reactor’s speed and efficiency without the need for additional photosensitizers. Compared to traditional batch processes, continuous flow mode using the PhotoCube™ yielded faster results and superior control.

Improving Laboratory Workflows

The research presented in this study and our own experimental data demonstrates the PhotoCube™‘s dual features in batch and flow processes, modular design, and user-friendly controls, making it an essential instrument for streamlining photochemical laboratory workflows for researchers.