We are excited to announce a partnership with Premex Solutions GmbH, a specialist in high-pressure batch technology and magnetic coupling. Our goal is to showcase the H-Genie®’s batch mode by connecting it to high-pressure batch reactors. This provides a unique solution in pharmaceutical R&D.

Premex is known for their durable, reliable, and high-quality batch reactors across Europe. They specialize in high-pressure chemistry, which makes the H-Genie® the most suitable hydrogen source for their applications.

Recently, we published a joint application note with Premex. By connecting Premex’s Apart reactor to the H-Genie®, we could efficiently showcase the catalytic hydrogenation of difluoro-nitrobenzene, a building block for the synthesis of complex molecules in pharmaceutical development.

We prepared a 30 mL, 1 M methanolic solution with 80 mg of 10% Pd/C catalyst. After that, we conducted the reaction at 35 °C temperature, 30 bar pressure, and 400 RPM stirring speed. The precise monitoring of hydrogen consumption and reaction temperature allowed our team to determine that the reaction was complete at approximately 41 minutes. Finally, we investigated the accuracy of the method using HPLC-MS analysis.

As world leaders in continuous flow chemistry, we are dedicated to making knowledge accessible to all scientists. Our mission is to support education, research, and scientific collaborations, empowering scientists to share their experiences and find inspiration. Explore our Application Notes to discover how ThalesNano instruments can change your chemical research and help you achieve your chemistry goals.