As May begins, ThalesNano is thrilled to share important developments in the world of chemistry. Read about expert perspectives, notable events, and valuable scientific resources.
3,3-Bis(hydroxyaryl)oxindoles and Spirooxindoles Bearing a Xanthene Moiety: Synthesis, Mechanism, and Biological Activity (Bálint et. al., 2025)
The Journal of Organic Chemistry
This study explores the development of a continuous-flow method for the synthesis of biologically active 3,3‑bis(hydroxyaryl)oxindoles and xanthene‑bearing spirooxindoles, which are valuable molecules in the pharmaceutical industry. The research team employed ThalesNano’s H-Cube® Pro flow reactor to conduct their experiments, utilizing the reactor’s CatCart® technology, on-demand hydrogen generation, and adjustable parameters to streamline complex chemical processes.
Can a Simple Surrogate Model System Be Used to Develop a Continuous Flow Packed Bed Hydrogenation for a Complex Molecule? (Kappe et. al., 2025)
Organic Process Research & Development
This publication presents a novel continuous flow method for the catalytic hydrogenolysis of Cbz-protected glycopeptide (Cbz-GP) by screening a surrogate molecule, Cbz-protected lysine (Cbz-Lys), in the presence of additives. Central to this research is the utilization of ThalesNano’s H-Genie® hydrogen generator, which enabled safe and efficient on-demand hydrogen production for the flow hydrogenation steps.
Continuous Flow Alkylation of Morpholine and Aniline catalyzed by Mesoporous Al-SBA-15 (Luque et al., 2025)
Asian Journal of Organic Chemistry
This study showcases the synthesis of N-methylated aniline and morpholine derivatives, compounds vital to the pharmaceutical, agrochemical, and polymer industries, using a mesoporous AI-SBA catalyst. The research team utilized ThalesNano’s Phoenix Flow Reactor, which enabled reactions at elevated temperatures and pressures, facilitating efficient and scalable synthesis. By integrating the Phoenix Flow Reactor into their workflow, the researchers achieved a streamlined and intensified process for oxadiazole synthesis, demonstrating the reactor’s potential in advancing continuous-flow methodologies in organic synthesis.
CHEMUK 2025 & ICGSC 2025
We would like to express our gratitude to everyone who visited our booths at Chemical UK Expo in the NEC, Birmingham, UK, and the International Conference on Green & Sustainable Chemistry in the ELTE Convention Centre in Budapest, Hungary.
Our experts gained valuable insights through scientific presentations and discussions with industry experts, which continuously inspire our flow chemistry R&D to this day.
Stay updated on where to meet us next – keep your eye on our website.
Revolutionizing chemical synthesis – The H-Cube® Advance
ThalesNano would like to sincerely thank everyone who took interest in our webinar! Our chemists were honored to have the opportunity to interact with viewers live and discuss our newest flow chemistry technologies.
Missed the live webinar? If you’re interested in the contents, you can view the recording on the link below.
Subscribe to our YouTube channel for more educational content!
Reactor Module for the H-Cube® Advance
Improve the reaction capabilities of your H-Cube® Advance flow reactor with our newest add-on, the Reactor Module. You can connect multiple modular devices to the H-Cube® Advance through the THS System Controller® and THS ReAction® Software. The device provides a better price-to-value option compared to the CatCart® Changer. Connecting the modules with the H-Cube® Advance through a loop selector valve makes them suitable for catalyst testing or multi-step reactions.
Stay tuned for further scientific updates next month!
