As May begins, ThalesNano is thrilled to share important developments in the world of chemistry, including expert perspectives, notable events, and valuable scientific resources.
Join our live webinar!
If you’re interested in revolutionizing your chemical synthesis, attend our live webinar on May 27, 4PM UTC (9AM PDT) or May 29, 8AM UTC (1:30PM IST)! Two webinars will be hosted to accommodate interested researchers globally. Nandor Kanya PhD, our Director of Chemistry, will explore the fundamentals of flow hydrogenation, and showcase the wide range of applications enabled by our newest flow reactor, the H-Cube® Advance. A Q&A session will also be hosted at the end of the webinar.
Don’t miss out, save the links:
May 27, 4PM Coordinated Universal Time
(Recommended for American and European time zones)
May 29, 8AM Coordinated Universal Time
(Recommended for European and Asian time zones)
Using the H-Cube® Mini Plus in the Continuous Flow Synthesis of Drugs – How Flow Chemistry Can Facilitate API Research
ThalesNano’s newest application note consists of three studies that showcase the versatility of the H-Cube® Mini Plus:
🔹Accelerated Benzocaine Synthesis: Rodrigo de Souza’s team demonstrated >99% conversion and selectivity for benzocaine in a single-step, 12-second reaction —significantly streamlining traditional multi-step batch synthesis.
🔹Advancement in Biocatalysis: Kylie A. Vincent and colleagues utilized the H-Cube® Mini Plus to achieve an efficient, hydrogen-powered reduction of riboflavin — offering a promising pathway toward cost-effective and sustainable cofactor regeneration systems.
🔹Theranostic Development: Tamás Kálai’s research group employed the H-Cube® Mini Plus for a key hydrogenation step in the synthesis of a spin-labeled Varenicline analogue—contributing to ongoing innovations in diagnostic-therapeutic hybrid technologies.
Highly dispersed WOm enables efficient reductive debenzylation of hexabenzylhexaazaisowurtzitane (HBIW) over bifunctional Pd-WOm/CeO₂ (Niu et al., 2025)
This study introduces a novel bifunctional Pd-WOm/CeO₂ catalyst that achieves efficient reductive debenzylation of HBIW, a key intermediate in the synthesis of high-energy-density materials, utilizing the H-Cube® Pro flow reactor’s in-situ hydrogen generation and adjustable reaction parameters.
New N-Alkylketonetetrahydroisoquinoline derivatives exhibit antitumor effect by HA-CD44 interaction inhibition in MDA-MB-231 breast cancer (Chayah et al., 2025)
Bioorganic Chemistry
This study presents novel N-alkylketonetetrahydroisoquinoline derivatives that inhibit HA-CD44 interactions, showing significant antitumor activity against MDA-MB-231 breast cancer cells. The researchers utilized the H-Cube® Pro flow reactor, demonstrating its efficiency in precise continuous-flow hydrogenation.
CHEMUK 2025
May 21-22, NEC, Birmingham, UK
Visit booth G92 at CHEMUK, the UK’s largest B2B trade show supporting the chemicals, process engineering, and formulated product industries. We will officially unveil our latest flow reactor, the H-Cube® Advance, at the conference. Our experts are looking forward to speaking with you in person.
ICGSC 2025
June 1-5, Eötvös Lorand University, Budapest, Hungary
We’re thrilled to announce that ThalesNano is going to exhibit at the International Conference on Green & Sustainable Chemistry, organized by the Hungarian Chemical Society and the EuChemSoc Division of Green Sustainable Chemistry. Besides providing a high-level and an interdisciplinary program in green and sustainable chemistry, the expo offers an outstanding venue for early career researchers. Visit our booth and our oral lecture to learn how ThalesNano’s continuous flow technologies can enhance green and sustainable chemistry.
Claim 10% off the registration fee by typing code ThalesNano in the “Notes” field!
H-Cube® Advance
Discover our latest bench-top flow reactor, which isn’t simply a hydrogenation device – the H-Cube® Advance can conduct reactions with 14 gases, like nitrogen, oxygen, carbon-oxides, argon, and many more through its built-in mass flow controller. The reactor has a temperature range of 0-150°C, enabling a wider range of reactions than its predecessor, the H-Cube® Pro.
H-Cube® Advance Overview
Pressure Module
Control and monitor your reactors’ system pressure with ThalesNano’s updated Pressure Module! The device is designed for liquids, gases, and gas-liquid mixtures, moreover, its user-friendly interface and compatibility with ThalesNano’s other products – including the Instrument Fleets and the Phoenix Flow Reactor – allows for seamless pressure control.
Mixer Module
Reach faster and more efficient mixing of gases into liquids under high-pressure (up to 200 bar) conditions by our Mixer Module! The instrument is highly compatible with our other products including the Phoenix Flow Reactor, moreover, the module is available in stainless steel and Hastelloy (C276) versions, enabling a wide range of chemical reactions.
Stay tuned for further updates next month!
