Performing Thiol-Ene Click Reactions in the PhotoCube – New Photochemistry Application Note

Photochemistry in batch and flow

In a major leap forward for synthetic photochemistry, ThalesNano’s PhotoCube is revolutionizing how photochemical reactions are performed — both in batch and continuous flow. This cutting-edge reactor, equipped with powerful LED panels across a wide wavelength range (365–623 nm), allows researchers to explore multiple photo-initiated reaction pathways simultaneously, including the Nobel Prize-winning thiol-ene click reactions.

Comparing Processes

A recent collaboration with the University of Debrecen highlights the PhotoCube’s power: researchers achieved rapid, high-yield conversions in thiol-ene additions using methanol under blue LED light—demonstrating the reactor’s speed and efficiency without the need for additional photosensitizers. Compared to traditional batch photochemistry processes, continuous flow mode using the PhotoCube yielded faster results and superior control.

PhotoCube flow and batch mode graph

Improving Laboratory Workflows

The research presented in this study and our own experimental data demonstrates the PhotoCube‘s dual features in batch and flow processes, modular design, and user-friendly controls, making it an essential instrument for streamlining photochemical laboratory workflows for researchers.

At ThalesNano, we embrace the power of photochemistry and continuous flow technology to unlock new possibilities in photochemical synthesis. All in all, our cutting-edge solutions enable researchers to harness the benefits of safe, efficient, and productive photochemical transformations.

Further Photochemical Knowledge

As world leaders in continuous flow chemistry, we are dedicated to making knowledge accessible to all scientists. Our mission is to support education, research, and scientific collaborations, empowering scientists to share their experiences and find inspiration. Explore our Application Notes to discover how ThalesNano instruments can change your chemical research and help you achieve your chemistry goals.