4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-based P2X7 receptor antagonists: optimization of pharmacokinetic properties leading to the identification of a clinical candidate

Letavic, M. A.; Savall, B. M.; Allison, B. D.; Aluisio, L.; Andres, J. I.; De Angelis, M.; Ao, H.; Beauchamp, D. A.; Bonaventure, P.; Bryant, S.; Carruthers, N. I.; Ceusters, M.; Coe, K. J.; Dvorak, C. A.; Fraser, I. C.; Gelin, C. F.; Koudriakova, T.; Liang, J.; Lord, B.; Lovenberg, T. W.; Otieno, M. A.; Schoetens, F.; Swanson, D. M.; Wang, Q.; Wickenden, A. D.; Bhattacharya, A.; J. Med. Chem., 2017, 60(11), 4559-4572

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