Learn about all that’s new at ThalesNano in November – including the most recent scientific materials, events, and product news.
Development of a Continuous Flow Synthesis of Ezogabine: Process Optimization and Scale-Up (Payne et al., 2025)
Organic Process Research & Development
This study published by BIOVECTRA and Xenon Pharmaceuticals illustrates how continuous flow hydrogenation technology can reduce the process and manufacturing mass intensity compared to batch methods. The research team synthesized Ezogabine – an antiepileptic agent used for the treatment of partial seizures – using a Raney-Nickel catalyst in the Phoenix Flow Reactor system. This method allowed for significantly shorter reaction times (under 2 seconds) and reduced PMI (26), ultimately contributing to cost reductions and adopting green processes.
Hydrogenation of Quinolines and Aldehydes Catalyzed by a Pyrolyzed, Augmented Cobalt-Salen Complex (Topf et al., 2025)
ACS Omega
Researchers from the Johannes Kepler University and the Leibniz Institute for Catalysis at the University of Rostock describe a new, low-cost heterogeneous catalyst based on an enlarged salcomine-type cobalt complex, for efficiently hydrogenating quinolines and aldehydes into 1,2,3,4-tetrahydroquinolines and primary alcohols respectively. The catalyst was tested under batch conditions in steel autoclaves, and ThalesNano’s H-Cube® Mini Plus flow reactor, which generates hydrogen gas on demand through water electrolysis, contributing to reaction safety.
Chemo-Enzymatic Cascades for the Sustainable Transformation of Canola Oil into Hydrocarbon Fuels (de Souza et al., 2025)
RSC Sustainability
A group of scientists from the Federal University of Rio de Janeiro showcased a chemo-enzymatic cascade process converting canola oil into fuel-like hydrocarbons by combining enzymatic hydrolysis with continuous flow catalytic hydrogenation using an H-Cube® Mini Plus with a Pd/C catalyst, and a final enzymatic photodecarboxylation step – using the PhotoCube – to produce alkanes suitable for low-oxygen-content biofuels. By utilizing the safety and precision of ThalesNano reactors, this study offers a more sustainable route for the valorization of vegetable oils, ultimately contributing to the advancement of green technologies.
Browse our publication database
If you would like to read more recent studies, visit ThalesNano’s publication database!
Interested in our H-Cube® Advance flow reactor? View it in action
Tour in Italy
Partnered with our Italian distributor STEPBIO, we brought the H-Cube® Advance flow reactor to 3 Italian universities and held a demonstration for local companies and academic institutes. The tour was held November 13-14, 2025, in the following institutes:
- University of Milano, Milano, Italy
- University of Parma, Parma, Italy
- University of Bologna, Bologna, Italy
We are thankful to everyone who attended the presentation and hope to foster more partnerships in the future.
Contact our Italian distributor to learn more about the H-Cube® Advance:
Stefano Giovanninetti
STEPBIO S.r.l.
Email: stefano.giovanninetti@stepbio.it
Phone: +39 (0) 51 634 3340
Website: https://www.stepbio.it/
Tour in Belgium
Our next location of the tour is Belgium, where we will hold a one-day presentation of the H-Cube® Advance with the assistance of Beun-De Ronde Serlabo, our Belgian distributor.
Tour date: December 2, 2025
Tour location: Ghent University, Ghent, Belgium
Join the tour or learn more by contacting our distributor:
Ann Dewinne
Beun-De Ronde Serlabo Srl
E-mail: dewinne@brs.be
Phone: +32 2 334 22 70
Website: https://www.brs.be/
H-Cube® Advance Hastelloy – 10% off all units
(Until the end of 2025)
Get a 10% discount on the H-Cube® Advance Hastelloy flow reactor by requesting a quote until the end of 2025! Compared to its stainless steel counterpart, this instrument’s liquid path is made from Hastelloy C, allowing for reactions with corrosive materials like acids and oxidizers.
Contact us for the discount
Reactor Module – Simple Tool for Catalysis in Academic Research
Discover how our new Reactor Module can make heterogeneous catalysis safer, quicker, and easier in your research lab! This budget-friendly heating-cooling device provides a wide parameter window (temperature: 0 – 150 °C, pressure: up to 100 bar), enabling a variety of important reactions like cross-couplings and many more.
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Stay tuned for more scientific updates next month!
