Deprotection reactions using the H-Cube® continuous flow reactor

Protecting groups play a central role in modern organic synthesis. The benzyl groups and benzyl carbamate or Cbz groups are some of the most commonly used protecting groups and play a central role in the protection of alcohols, carboxylic acids and amines. The benzyl and benzyl carbamate groups are removed using catalytic hydrogenation using elevated temperature. The H-Cube^® is able to remove benzyl groups from amines, acids or alcohols very efficiently in one pass through a 10% Pd/C CatCart^®. This application note gives examples of deprotection reactions performed on the H-Cube^®.