If you are looking for broad reaction examples with H-Cube® Mini Plus, download our application overview.
DownloadSimple flow deuterodehalogenation using polymer-based activated carbon (PBSAC) supported palladium catalysts in CatCart®
Deuterium-labelling is a widely used method in the fields of biomedical, chemical and pharmaceutical industry.
The FDA recently approved the first deuterated API, and nowadays several molecules with deuterated moieties are under clinical testing in order to treat Alzheimer’s, cystic fibrosis, Freidreich’s ataxia, and psoriasis. The kinetic isotope effect enhances pharmacokinetic properties of deuterium-labelled molecules, which might lead to high therapeutic values.
Continuous-flow deuteration has been demonstrated in the H-Cube® before, however the possibility to use it in a green chemical solvent is practically unexplored.
DownloadContinuous Ozonolysis as a Key Step of the Darunavir Synthesis Using the IceCube™ Flow Reactor
AIDS is one of the most threatening diseases spread across the planet, affecting about 35 million people worldwide. To improve the quality of life of those affected by HIV, a number of antivirals were developed, such as Darunavir. This molecule has a complex bicyclic core, the synthesis of which is well documented in the literature.
State of the art: An approach described by Ghosh and his co-workers includes an ozonolysis step, which is performed under batch conditions resulting in the desired ketone with 98% yield after 3 hours.[6,7] However, handling the gaseous ozone and working at a very low temperature (78°C) is inconvenient. Adapting the synthesis to a continuous flow system
provides a safe and rapid alternative solution by using in-situ generated ozone, a closed system, and higher temperatures. In this application note, we demonstrate that continuous flow ozonolysis can easily be carried out utilizing the IceCube™ Flow Reactor, developed by ThalesNano, in a safe and efficient way.
Ethanol oxidation with heterogeneous catalysis in flow: a batch to flow conversion
Acetic acid is considered to be an important chemical commodity as both a solvent and Bronsted acid. Being one of the first organic molecules that was synthesized in history (Kolbe, 1845), there are a wide range of procedures for its manufacturing. Despite this fact, industrial scale production now requires more environmentally friendly solutions for its sustainable production.
Heterogeneous catalysis has been found to be a useful alternative method to the current Monsanto process industry currently utilizes. With the combination of ThalesNano’s Phoenix Flow Reactor™ and Gas Module™ a reactor system has been built, which is capable to control high temperature–high pressure triphasic gas-liquid-solid reactions providing a safe and efficient environment for organic chemists.
DownloadPolymerization and grafting onto particle surfaces via continuous flow chemistry
Polymer grafted inorganic particles are attractive building blocks for numerous chemical and material applications. Surface initiated controlled radical polymerization (SI-RAFT) is one of the most feasible methods to fabricate these materials. However, conventional in-batch approaches still suffer from several disadvantages, such as time-consuming purification processes, inefficient grafting, and possible gelation problems. A facile method was demonstrated to synthesize homopolymers and block copolymer grafted inorganic particles using continuous flow chemistry in an environmentally friendly aqueous media using the Phoenix Flow Reactor.
DownloadThermal cyclisation leading to important heterocyclic carbonyl intermediates using X-Cube Flash™ reactor
Heterocyclic carbonyl compounds e.g. quinolones, pyridopyrimidinones, naphthyridinones are important structural motifs in various biological active compounds (e.g. norfloxacin, nalidixic acid). One of the most practical approaches for their synthesis is the thermal cyclisation of the appropriate open chain intermediates containing a suitably substituted 3 carbon extension on the nitrogen.
DownloadChemistry at high temperature and pressure – using the X-Cube Flash™ continuous flow reactor
The X-Cube Flash™ is a continuous-flow system that can heat and pressurize solutions up to 350°C and 200 bar respectively. The high temperature and pressure significantly decrease reaction times and allows solvents to be reacted under supercritical
conditions. This application note demonstrates the results of important chemical reactions carried out in the X-Cube Flash™ reactor with comparison to literature results based on conventional batch or microwave-assisted reactions.
Efficient Curtius-rearrangement using X-Cube Flash™ continuous flow reactor
ThalesNano has developed a high pressure/high temperature continuous flow reactor, called X-Cube Flash™, to allow chemists to reach chemistry reaction extremities easier and safer compared to batch. In this application note we will focus on the study of the Curtius-reaction from an acyl azide as well ans from acids through in situ formation of the acyl azide using the X-Cube Flash™ reactor.
DownloadAromatic nucleophilic substitutions using X-Cube Flash™ continuous flow reactor
ThalesNano has developed a high pressure/high temperature continuous flow reactor, called X-Cube Flash™, as a viable alternative to MW-chemistry. Several reactions previously reported under MW conditions were realized in the X-Cube Flash™ with improved yield and radically shortened reaction time under safe operation. Our objective was to study the nucleophilic aromatic substitution reaction (F-amine exchange) in metapositions, since the substituted mono- and diaminobenzonitriles are important biological active molecules.
DownloadReductive amination of ketones: novel one-step transfer hydrogenations
Amines are indispensable building blocks in numerous drugs, pesticides and colour pigments. Development of general and efficient methods to prepare amino-compounds is still of high interest to the chemical industry. One of the most convenient methods to synthesize amines is the reductive amination of carbonyl compounds.
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