H-Cube® Application Note
ThalesNano is already well-known for its novel solutions in revolutionizing heterogeneous catalytic hydrogenations with its H-Cube® hydrogenator, while the expanded Cube series of fixed bed reactors offers a broad range of chemistry applications. With a wide portfolio of different catalysts available in our proprietary CatCart® catalyst cartridges, ThalesNano is also heavily involved in the development, of novel catalysts, screening and profiling of catalysts.
Features
The Catalyst Screening and Profiling Program gives clients access to our expertise and novel in-house developed technologies, in which we are able to rapidly screen and profile catalyst activity in a broad range of different conditions.
Our business model is to take client problems and work together with them to find the optimal catalyst and reaction conditions for improved reaction performance.
The program includes:
- Rapid screening of over 80 off the shelf catalysts from the ThalesNano CatCart® portfolio (available for heterogenous hydrogenations and a broad range of other gaseous and non-gaseous reactions)
- Stereo-/enantioselective catalysis, biocatalysis
- Screening and Profiling of client specified catalysts
- Catalyst Immobilization
- Research into alternative catalysts outside of ThalesNano own portfolio
- Joint development of tailor-made catalysts
- Full optimization of the reaction parameters and conditions
Advantages
The fully automated ThalesNano Cube series of reactors enable ultra-fast reaction optimization, even within minutes allowing a vast array of catalysts to be screened in a short period of time.
The microflow process gives detailed control over the reaction conditions, allowing enabling highly reproducible results.
The ThalesNano team has over 15 years of experience in contract research projects, with a highly trained team of experts.
Catalyst srreening and profiling application notes
The fully automated ThalesNano Cube series of reactors enable ultra-fast reaction optimization, even within minutes allowing a vast array of catalysts to be screened in a short period of time.
The microflow process gives detailed control over the reaction conditions, allowing enabling highly reproducible results.
The ThalesNano team has over 15 years of experience in contract research projects, with a highly trained team of experts.
References
[1] R. V. Jones, L. Godorhazy, N. Varga, D. Szalay, L. Ürge, F. Darvas, J. Combi. Chem. 8 (2005) 110.
[2] B. Desai, O. Kappe, J. Combi. Chem. 7 (2005) 641.
[3] H. H. Horváth, G. Papp, C. Csajági, F. Joó, Cat. Commun. (2007) 442-446.
[4] S. Saaby, K. R. Knudsen, M. Ladlow, S. V. Ley, Chem. Commun. (2005) 2909.
[4] I. T. Horváth (Ed.-in-Chief), Encyclopedia of Catalysis, Wiley, New York, 2002.
[5] B. R. James, Homogeneous Hydrogenation, Wiley, New York, 1973.
[6] P. A. Chaloner, M. A. Esteruleas, F. Joó, L. A. Oro, Homogeneous Hydrogenation, Kluwer, Dordrecht, 1994.
Example 1. [3]
Quick optimization of the temperature on the stereoselective hydrogenation of diphenylacetylene with [{RuCl2(mtppms)2}2] anchored on DEAE-Molselect. Flow rate = 1 mL/min, p(H2) = 30 bar.
Example 2. [3]
Quick optimization of the flow rate on the stereoslective hydrogenation of diphenylacetylene with [{RuCl2(mtppms)2}2] anchored on DEAE-Molselect. T = 50°C, p(H2) = 30 bar.
Example 3. [3]
Stability of a novel [{RuCl2(mtppms)2}2] catalyst anchored on Lewatit Mono-Plus in the hydrogenation of diphenylacetylene. T = 30°C, p(H2) = 30 bar.
