Asymmetric hydrogenation using H-Cube® continuous flow reactor

Catalytic asymmetric hydrogenation is one of the most efficient and convenient methods for synthesizing optically active compounds, e.g. amino acids, chiral amines and itaconic acids, which are widely used in the pharmaceutical and fine chemical industries.
At ThalesNano we have performed asymmetric hydrogenation on the H-Cube® flow hydrogenation system using solid-supported Rh catalysts bearing chiral phophorus ligands. The catalyst PTA/Al2O3/[Rh(COD)(chiral ligand)] was tested in the chiral hydrogenation of (Z)-α-acetamidocinnamic acid methyl ester.