Difficult hydrogenations – saturation of functionalized pyridines

The saturation of aromatic ring systems is one of the hardest reactions in hydrogenation. Reactions are typically performed at high temperature and pressure (above 80 bar, 80 °C). Typical laboratory batch reactors are not capable of reaching these conditions and so, either the reaction does not work or the reactions take days. The H-Cube^® flow hydrogenation reactor is capable of performing reactions at 100 °C and 100 bar safely. The H-Cube^®’s improved mixing efficiency coupled with high temperature and pressure abilities means difficult reactions can be performed in minutes. Here are a few examples.