Rapid catalyst screening for Sonogashira coupling using H-Cube® continuous flow reactor

ThalesNano’s H-Cube® can be used to perform reactions other than hydrogenation by utilizing “No H2” mode. In “No H2” mode, the H-Cube® reactor can perform reactions at temperatures and pressures up to 100 °C and 100 bar, respectively in the absence of a reagent gas. In this application note we will be focusing on Sonogashira chemistry.