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Optically pure, structural, and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach
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Structure-activity relationship studies of mitogen activated protein kinase interacting kinase (MNK) 1 and 2 and BCR-ABL1 inhibitors targeting chronic myeloid leukemic cells
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Discovery of narrow spectrum kinase inhibitors: New therapeutic agents for the treatment of COPD and steroid-resistant asthma
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Discovery of a novel inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) as orally active antitumor agent
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Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow
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Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis
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Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)
Zheng, Z.; Pinson, J. A.; Mountford, S. J.; Orive, S.; Schoenwaelder, S. M.; Shackleford, D.; Powell, A.; Nelson, E. M.; Hamilton, J. R.; Jackson, S. P.; Jennings, I. G.; Thompson, P. E.; Eur. J. Med. Chem., 2016, 122, 339-351
Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure–activity relationship (SAR) studies
Nuzzi, A.; Fiasella, A.; Ortega, J. A.; Pagliuca, C.; Ponzano, S.; Pizzirani, D.; Bertozzi, S. M.; Ottonello, G.; Tarozzo, G.; Reggiani, A.; Bandiera, T.; Bertozzi, F.; Piomelli, D.; Eur. J. Med. Chem., 2016, 111, 138-159
Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch
Gallagher, C. M.; Garri, C.; Cain, E. L.; Ang, K. K. H.; Wilson, C. G.; Chen, S.; Hearn, B. R.; Jaishankar, P.; Aranda-Diaz, A.; Arkin, M. R.; Renslo, A. R.; Walter, P.; eLife, 2016, 5, e:11878