July Highlights 2025

18/07/2025
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As summer is in full swing in the middle of July, ThalesNano is eager to provide you with fresh scientific materials and upcoming key events in the field of flow chemistry.

ThalesNano events, conferences July

Analytica USA

September 10-12, 2025
Columbus Convention Center (GCCC)
Columbus, Ohio, US

We’re thrilled to be an exhibitor at analytica USA, the world-leading trade fair for analysis and laboratory technology. The conference will be held in Hall B of the Greater Columbus Convention Center (GCCC), in Columbus, Ohio, US. Make sure to visit booth 1240 to talk to our experts and get a glimpse at our flow chemistry technologies in person!

[Get your ticket]

ThalesNano scientific publications July

Continuous Flow valorization of furanics: From decarbonylation of 5-hydroxymethylfurfural to furfuryl alcohol conversion into valuable oxidative coupling products (Luque et al., 2025)

Catalysis Today

This publication focuses on the multi-step valorization of 5-hydroxymethylfurfural (HMF) to valuable furanic derivatives using a 10% Pd/C catalyst in the Phoenix Flow Reactor. Designed for extreme environments, the Phoenix enabled precise control at up to 450 °C and 200 bar, providing safe, scalable processing of demanding transformations that are difficult to perform in batch systems.

Read the publication here.

Effect of iron oxidation state on the catalytic performance of Fe/C in liquid phase flow hydrogenation of 2-butyne-1,4-diol (Srebowata et al., 2025)

Fuel

In a recent study, researchers explored the selective hydrogenation of 2-butyne-1,4-diol using low-cost Fe/C catalysts — achieving 100% selectivity at 1 bar H₂ and 25 °C. All experiments were performed using ThalesNano’s H-Cube® continuous-flow reactor, which provided precise control over hydrogen generation and reaction conditions. The study highlights the potential of combining earth-abundant catalysts with advanced flow technology to enable efficient, sustainable hydrogenation processes.

Read the publication here.

Photochemical processes in aqueous benzoquinone and anthraquinone solutions studied by spectrophotometry (Ősz et al., 2025)

Reaction Kinetics, Mechanisms and Catalysis

This study used ThalesNano’s PhotoCube™ photoreactor to illuminate aqueous solutions of benzoquinone and anthraquinone derivatives across multiple LEDs (UV, violet, blue, and white light). Monitoring via spectrophotometry coupled with matrix rank and M³ analysis revealed diverse photoproducts — primarily mixtures of hydroquinone and hydroxyquinone — and highlighted how choice of wavelength, light intensity, and temperature subtly influenced reaction pathways and kinetics. This work underscores the PhotoCube™’s versatility in precisely dissecting complex photochemical behavior in homogeneous liquid systems.

Read the publication here.

Browse our publication database

If you would like to read more recent studies, visit ThalesNano’s publication database!

Flow chemistry product news and promotions July

Sign up for our LinkedIn newsletter

Want to receive monthly updates but prefer using LinkedIn over email communication? Subscribe to our LinkedIn newsletter, where you can immediately find the latest scientific materials from ThalesNano in your Notifications tab!

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Modular system for parallel and/or consecutive experiments

Meet our scalable platform for multi-phase catalytic reactions, the Instrument Fleets! Unlike standalone flow reactors, this platform offers a highly customizable, scalable solution to perform high-temperature, high-pressure reactions. Aside from ThalesNano instruments, the platform supports a wide range of third-party devices. This versatile system is suitable for pharmaceutical, petrochemical, and green chemistry applications alike.

[Learn More]

Reactor Module

Improve the efficiency of your catalyst testing/screening with the Reactor Module! By connecting a custom amount of Reactor Modules to the H-Cube® Advance via the THS System Controller, you can achieve safe and efficient multi-step reactions at an affordable price.

[Learn More]

H-Cube® Advance – Webinar

If you missed our live webinar hosted by Dr. Kánya on how our newest flow reactor, the H-Cube® Advance, can extend your chemical synthesis capabilities, we have created a permanent link where you can view the lecture at any time.

[Watch Webinar]

Stay tuned for further scientific updates next month!

Scientific Highlights – June, 2025

24/06/2025
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As June begins, ThalesNano welcomes the summer season with renewed vigor. We’re excited to share the newest updates from the field of flow chemistry, including key events and informative scientific resources.

ThalesNano scientific publications

3,3-Bis(hydroxyaryl)oxindoles and Spirooxindoles Bearing a Xanthene Moiety: Synthesis, Mechanism, and Biological Activity (Bálint et. al., 2025)

The Journal of Organic Chemistry

This study explores the development of a continuous-flow method for the synthesis of biologically active 3,3‑bis(hydroxyaryl)oxindoles and xanthene‑bearing spirooxindoles, which are valuable molecules in the pharmaceutical industry. The research team employed ThalesNano’s H-Cube® Pro flow reactor to conduct their experiments, utilizing the reactor’s CatCart® technology, on-demand hydrogen generation, and adjustable parameters to streamline complex chemical processes.

Read the publication here.

Can a Simple Surrogate Model System Be Used to Develop a Continuous Flow Packed Bed Hydrogenation for a Complex Molecule? (Kappe et. al., 2025)

Organic Process Research & Development

This publication presents a novel continuous flow method for the catalytic hydrogenolysis of Cbz-protected glycopeptide (Cbz-GP) by screening a surrogate molecule, Cbz-protected lysine (Cbz-Lys), in the presence of additives. Central to this research is the utilization of ThalesNano’s H-Genie® hydrogen generator, which enabled safe and efficient on-demand hydrogen production for the flow hydrogenation steps.

Read the publication here.

Continuous Flow Alkylation of Morpholine and Aniline catalyzed by Mesoporous Al-SBA-15 (Luque et al., 2025)

Asian Journal of Organic Chemistry

This study showcases the synthesis of N-methylated aniline and morpholine derivatives, compounds vital to the pharmaceutical, agrochemical, and polymer industries, using a mesoporous AI-SBA catalyst. The research team utilized ThalesNano’s Phoenix Flow Reactor, which enabled reactions at elevated temperatures and pressures, facilitating efficient and scalable synthesis. By integrating the Phoenix Flow Reactor into their workflow, the researchers achieved a streamlined and intensified process for oxadiazole synthesis, demonstrating the reactor’s potential in advancing continuous-flow methodologies in organic synthesis.

Read the publication here.

ThalesNano events, conferences

CHEMUK 2025 & ICGSC 2025

We would like to express our gratitude to everyone who visited our booths at Chemical UK Expo in the NEC, Birmingham, UK, and the International Conference on Green & Sustainable Chemistry in the ELTE Convention Centre in Budapest, Hungary.

Our experts gained valuable insights through scientific presentations and discussions with industry experts, which continuously inspire our flow chemistry R&D to this day.

Stay updated on where to meet us next – keep your eye on our website.

Rewatch recent flow chemistry webinar

Revolutionizing chemical synthesis – The H-Cube® Advance

ThalesNano would like to sincerely thank everyone who took interest in our webinar! Our chemists were honored to have the opportunity to interact with viewers live and discuss our newest flow chemistry technologies.

Missed the live webinar? If you’re interested in the contents, you can view the recording on the link below.

[Watch the Webinar]

Subscribe to our YouTube channel for more educational content!

[Visit channel]

Flow chemistry product news and promotions

Reactor Module for the H-Cube® Advance

Improve the reaction capabilities of your H-Cube® Advance flow reactor with our newest add-on, the Reactor Module. You can connect multiple modular devices to the H-Cube® Advance through the THS System Controller® and THS ReAction® Software. The device provides a better price-to-value option compared to the CatCart® Changer. Connecting the modules with the H-Cube® Advance through a loop selector valve makes them suitable for catalyst testing or multi-step reactions.

[Learn More]

Stay tuned for further scientific updates next month!

Performing Thiol-Ene Click Reactions in the PhotoCube – New Photochemistry Application Note

02/06/2025

Photochemistry in batch and flow

In a major leap forward for synthetic photochemistry, ThalesNano’s PhotoCube is revolutionizing how photochemical reactions are performed — both in batch and continuous flow. This cutting-edge reactor, equipped with powerful LED panels across a wide wavelength range (365–623 nm), allows researchers to explore multiple photo-initiated reaction pathways simultaneously, including the Nobel Prize-winning thiol-ene click reactions.

Comparing Processes

A recent collaboration with the University of Debrecen highlights the PhotoCube’s power: researchers achieved rapid, high-yield conversions in thiol-ene additions using methanol under blue LED light—demonstrating the reactor’s speed and efficiency without the need for additional photosensitizers. Compared to traditional batch photochemistry processes, continuous flow mode using the PhotoCube yielded faster results and superior control.

PhotoCube flow and batch mode graph

Improving Laboratory Workflows

The research presented in this study and our own experimental data demonstrates the PhotoCube‘s dual features in batch and flow processes, modular design, and user-friendly controls, making it an essential instrument for streamlining photochemical laboratory workflows for researchers.

At ThalesNano, we embrace the power of photochemistry and continuous flow technology to unlock new possibilities in photochemical synthesis. All in all, our cutting-edge solutions enable researchers to harness the benefits of safe, efficient, and productive photochemical transformations.

Further Photochemical Knowledge

As world leaders in continuous flow chemistry, we are dedicated to making knowledge accessible to all scientists. Our mission is to support education, research, and scientific collaborations, empowering scientists to share their experiences and find inspiration. Explore our Application Notes to discover how ThalesNano instruments can change your chemical research and help you achieve your chemistry goals.

Monthly Highlights – May, 2025

21/05/2025
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As May begins, ThalesNano is thrilled to share important developments in the world of chemistry, including expert perspectives, notable events, and valuable scientific resources.

H-Cube Advance webinar

Join our live webinar!

If you’re interested in revolutionizing your chemical synthesis, attend our live webinar on May 27, 4PM UTC (9AM PDT) or May 29, 8AM UTC (1:30PM IST)! Two webinars will be hosted to accommodate interested researchers globally. Nandor Kanya PhD, our Director of Chemistry, will explore the fundamentals of flow hydrogenation, and showcase the wide range of applications enabled by our newest flow reactor, the H-Cube® Advance. A Q&A session will also be hosted at the end of the webinar.

Don’t miss out, save the links:

May 27, 4PM Coordinated Universal Time

(Recommended for American and European time zones)

Join Webinar Premiere

May 29, 8AM Coordinated Universal Time

(Recommended for European and Asian time zones)

Join Webinar Premiere
ThalesNano scientific publications

Using the H-Cube® Mini Plus in the Continuous Flow Synthesis of Drugs – How Flow Chemistry Can Facilitate API Research

ThalesNano’s newest application note consists of three studies that showcase the versatility of the H-Cube® Mini Plus:

🔹Accelerated Benzocaine Synthesis: Rodrigo de Souza’s team demonstrated >99% conversion and selectivity for benzocaine in a single-step, 12-second reaction —significantly streamlining traditional multi-step batch synthesis.

🔹Advancement in Biocatalysis: Kylie A. Vincent and colleagues utilized the H-Cube® Mini Plus to achieve an efficient, hydrogen-powered reduction of riboflavin — offering a promising pathway toward cost-effective and sustainable cofactor regeneration systems.

🔹Theranostic Development: Tamás Kálai’s research group employed the H-Cube® Mini Plus for a key hydrogenation step in the synthesis of a spin-labeled Varenicline analogue—contributing to ongoing innovations in diagnostic-therapeutic hybrid technologies.

Read the application note here.

Highly dispersed WOm enables efficient reductive debenzylation of hexabenzylhexaazaisowurtzitane (HBIW) over bifunctional Pd-WOm/CeO₂ (Niu et al., 2025)

This study introduces a novel bifunctional Pd-WOm/CeO₂ catalyst that achieves efficient reductive debenzylation of HBIW, a key intermediate in the synthesis of high-energy-density materials, utilizing the H-Cube® Pro flow reactor’s in-situ hydrogen generation and adjustable reaction parameters.

Read the publication here.

New N-Alkylketonetetrahydroisoquinoline derivatives exhibit antitumor effect by HA-CD44 interaction inhibition in MDA-MB-231 breast cancer (Chayah et al., 2025)

Bioorganic Chemistry

This study presents novel N-alkylketonetetrahydroisoquinoline derivatives that inhibit HA-CD44 interactions, showing significant antitumor activity against MDA-MB-231 breast cancer cells. The researchers utilized the H-Cube® Pro flow reactor, demonstrating its efficiency in precise continuous-flow hydrogenation.

Read the publication here.

ThalesNano events

CHEMUK 2025

May 21-22, NEC, Birmingham, UK

Visit booth G92 at CHEMUK, the UK’s largest B2B trade show supporting the chemicals, process engineering, and formulated product industries. We will officially unveil our latest flow reactor, the H-Cube® Advance, at the conference. Our experts are looking forward to speaking with you in person.

Register for a free entry badge here.

ICGSC 2025

June 1-5, Eötvös Lorand University, Budapest, Hungary

We’re thrilled to announce that ThalesNano is going to exhibit at the International Conference on Green & Sustainable Chemistry, organized by the Hungarian Chemical Society and the EuChemSoc Division of Green Sustainable Chemistry. Besides providing a high-level and an interdisciplinary program in green and sustainable chemistry, the expo offers an outstanding venue for early career researchers. Visit our booth and our oral lecture to learn how ThalesNano’s continuous flow technologies can enhance green and sustainable chemistry.

Claim 10% off the registration fee by typing code ThalesNano in the “Notes” field!

Register here.

Flow chemistry product news and promotions

H-Cube® Advance

Discover our latest bench-top flow reactor, which isn’t simply a hydrogenation device – the H-Cube® Advance can conduct reactions with 14 gases, like nitrogen, oxygen, carbon-oxides, argon, and many more through its built-in mass flow controller. The reactor has a temperature range of 0-150°C, enabling a wider range of reactions than its predecessor, the H-Cube® Pro.

H-Cube® Advance Overview

Pressure Module

Control and monitor your reactors’ system pressure with ThalesNano’s updated Pressure Module! The device is designed for liquids, gases, and gas-liquid mixtures, moreover, its user-friendly interface and compatibility with ThalesNano’s other products – including the Instrument Fleets and the Phoenix Flow Reactor – allows for seamless pressure control.

Mixer Module

Reach faster and more efficient mixing of gases into liquids under high-pressure (up to 200 bar) conditions by our Mixer Module! The instrument is highly compatible with our other products including the Phoenix Flow Reactor, moreover, the module is available in stainless steel and Hastelloy (C276) versions, enabling a wide range of chemical reactions.

Stay tuned for further updates next month!