Deuterium-labeled compounds are widely used as research tools in chemistry. Their importance lies in a number of applications, such as: proving reaction mechanisms, investigation of a compound’s pharmacokinetic properties, internal standards in mass spectrometry, compound structure determination in NMR spectroscopy. Download
The H-Cube® continuous flow system is capable of generating deuterium gas from the electrolysis of D2O, which is readily available in 99.98% purity and is easy to handle.
The implementation of sustainable and environmentally friendly protocols is an emerging field of the chemical industry. The need for safe and reliable processes as the alternative of demanding, wasteful, toxic or hazardous methods is pointing towards a new paradigm in organic synthesis. Enabling technologies, like flow chemistry, especially continuous flow heterogeneous catalysis makes green and sustainable chemical procedures available. Download
Flow reactors are applied to conduct high temperature and high pressure chemistry towards extending the accessible chemical space to access new applications. Download
Ionic liquids have gained great interest during the last three decades due to their green and sustainable behavior along with their added versatility as solvents in inorganic and organic reactions as well. N-Alkylimidazole derivatives are key intermediates for the synthesis of quaternary ionic liquid salts. Download
The need for easy and fast high throughput screening tools to find target compounds which can be patented and produced in commercial scale is ever growing. Such a tool is flow chemistry, which is being employed in several chemical industries due to its benefits. In this application note we provide information from patents from major agrochemical companies, Syngenta and Dow Agrosciences, where flow chemistry was used for the synthesis of active compounds. Download
In this application note we report on the optimization of hydrogenation, oxidation and ring-closing reactions and their real time analysis. Homogeneous and heterogeneous reactions were performed in ThalesNano’s H-Cube Pro™, Gas Module and Phoenix Flow Reactor™ systems, while these reactions were monitored by Mettler Toledo’s FlowIR™ device. Download
This guide provides information on the optimized, general conditions for the hydrogenation of different N-heterocycles in order to easily generate novel compounds with a higher sp3/sp2 ratio. Download
ThalesNano is already well-known for its novel solutions in revolutionizing heterogeneous catalytic hydrogenations with its H-Cube® hydrogenator, while the expanded H-Cube series of fixed bed reactors offers a broad range of chemistry applications. With a wide portfolio of different catalysts available in our proprietary CatCart® catalyst cartridges ThalesNano is also heavily involved in the development, of novel catalysts, screening and profiling of catalysts. Download
In this application note we share the results of the optimization of the flow rate and temperature during the stereoselective hydrogenation of diphenyl acetyle. Furthermore, the longevity of the catalyst is also described, showing a slight increase in conversion and selective over 20 reactions.
The Gas Module works seamlessly with the H-Cube Pro allowing a further 13 gases to be used at up to 100 bar using the same touch screen intuitive controls. Reactions such as carbonylation or oxidation can now be performed on the H-Cube Pro at the same high pressure and ease of use, extending the reactor’s chemistry capacity significantly, as it is presented in this application note. Download
Modern flow chemistry methods offer new chemical space for drug discovery programs: novel compounds can be synthesized in dedicated high temperature/high pressure (high T/p) reactors, while reaction times can be shortened dramatically. Download